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https://www.readbyqxmd.com/read/28637749/cell-cycle-dependent-spatial-segregation-of-telomerase-from-sites-of-dna-damage
#1
Faissal Ouenzar, Maxime Lalonde, Hadrien Laprade, Geneviève Morin, Franck Gallardo, Samuel Tremblay-Belzile, Pascal Chartrand
Telomerase can generate a novel telomere at DNA double-strand breaks (DSBs), an event called de novo telomere addition. How this activity is suppressed remains unclear. Combining single-molecule imaging and deep sequencing, we show that the budding yeast telomerase RNA (TLC1 RNA) is spatially segregated to the nucleolus and excluded from sites of DNA repair in a cell cycle-dependent manner. Although TLC1 RNA accumulates in the nucleoplasm in G1/S, Pif1 activity promotes TLC1 RNA localization in the nucleolus in G2/M...
June 21, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28609131/a-comprehensive-reanalysis-of-the-distal-iliotibial-band-quantitative-anatomy-radiographic-markers-and-biomechanical-properties
#2
Jonathan A Godin, Jorge Chahla, Gilbert Moatshe, Bradley M Kruckeberg, Kyle J Muckenhirn, Alexander R Vap, Andrew G Geeslin, Robert F LaPrade
BACKGROUND: The qualitative anatomy of the distal iliotibial band (ITB) has previously been described. However, a comprehensive characterization of the quantitative anatomic, radiographic, and biomechanical properties of the Kaplan fibers of the deep distal ITB has not yet been established. It is paramount to delineate these characteristics to fully understand the distal ITB's contribution to rotational knee stability. Purpose/Hypothesis: There were 2 distinct purposes for this study: (1) to perform a quantitative anatomic and radiographic evaluation of the distal ITB's attachment sites and their relationships to pertinent osseous and soft tissue landmarks, and (2) to quantify the biomechanical properties of the deep (Kaplan) fibers of the distal ITB...
June 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28607939/the-role-of-the-peripheral-passive-rotation-stabilizers-of-the-knee-with-intact-collateral-and-cruciate-ligaments-a-biomechanical-study
#3
Alexander R Vap, Jason M Schon, Gilbert Moatshe, Raphael S Cruz, Alex W Brady, Grant J Dornan, Travis Lee Turnbull, Robert F LaPrade
BACKGROUND: A subset of patients have clinical internal and/or external knee rotational instability despite no apparent injury to the cruciate or collateral ligaments. PURPOSE/HYPOTHESIS: The purpose of this study was to assess the effect of sequentially cutting the posterolateral, anterolateral, posteromedial, and anteromedial structures of the knee on rotational stability in the setting of intact cruciate and collateral ligaments. It was hypothesized that cutting of the iliotibial band (ITB), anterolateral ligament and lateral capsule (ALL/LC), posterior oblique ligament (POL), and posteromedial capsule (PMC) would significantly increase internal rotation, while sectioning of the anteromedial capsule (AMC) and the popliteus tendon and popliteofibular ligament (PLT/PFL) would lead to a significant increase in external knee rotation...
May 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28589159/demographics-and-injuries-associated-with-knee-dislocation-a-prospective-review-of-303-patients
#4
Gilbert Moatshe, Grant J Dornan, Sverre Løken, Tom C Ludvigsen, Robert F LaPrade, Lars Engebretsen
BACKGROUND: Information on the incidence, injury mechanisms, ligament injury patterns, and associated injuries of knee dislocations is lacking in the literature. There is a need to characterize ligament injury patterns and associated injuries in knee dislocations to avoid missing common associated diagnoses and to plan surgical treatment. PURPOSE: To evaluate patient demographics, ligament injury patterns and associated injury patterns, and associated injuries in patients with knee dislocation...
May 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28580266/open-patellar-tendon-tenotomy-debridement-and-repair-technique-augmented-with-platelet-rich-plasma-for-recalcitrant-patellar-tendinopathy
#5
Bradley M Kruckeberg, Jorge Chahla, Marcio B Ferrari, George Sanchez, Gilbert Moatshe, Robert F LaPrade
Patellar tendinopathy is a disabling condition that frequently affects the athletic population, especially athletes undergoing repetitive impact forces as a result of jumping and landing activities. Most cases are initially treated conservatively, but if symptoms persist, surgical treatment is warranted. Options for surgical treatment include both arthroscopic and open techniques. The purpose of this Technical Note is to detail our open patellar tendon tenotomy, debridement, and repair technique augmented with platelet-rich plasma...
April 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28580265/bone-marrow-aspirate-concentrate-harvesting-and-processing-technique
#6
Jorge Chahla, Sandeep Mannava, Mark E Cinque, Andrew G Geeslin, David Codina, Robert F LaPrade
Bone marrow obtained by iliac crest aspiration is a common source for harvesting mesenchymal stem cells, other progenitor cells, and associated cytokine/growth factors. Recent studies have reported good to excellent outcomes with the use of bone marrow aspirate concentrate (BMAC) for pain relief in the treatment of focal chondral lesions and osteoarthritis of the knee. However, the harvesting and processing technique are crucial to achieve satisfactory results. Several studies have examined outcomes after BMAC injection, with encouraging results, but there is a lack of consensus in terms of the frequency of injection, the amount of BMAC that is injected, and the timing of BMAC injections...
April 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28580257/posterior-surgical-approach-to-the-knee
#7
Scott C Faucett, James Gannon, Jorge Chahla, Marcio B Ferrari, Robert F LaPrade
Posterior knee approaches are reliable techniques to address the treatment of various pathologies of the posterior region of the knee, including Baker cyst excision, tibial plateau fracture fixation, posterior cruciate ligament avulsions and inlay reconstructions, femoral condyle cartilage procedures, posterior meniscal repair and loose body removal among others. Surgery in the posterior knee region can be challenging because of the presence of neurovascular structures including the tibial nerve, popliteal artery and vein, and common peroneal nerve; thus, it is less commonly performed...
April 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28580255/arthroscopy-assisted-fabella-excision-surgical%C3%A2-technique
#8
Matthew T Provencher, George Sanchez, Márcio B Ferrari, Gilbert Moatshe, Jorge Chahla, Ramesses Akamefula, Robert F LaPrade
The fabella is an anatomic variant not seen in all individuals and can potentially be a source of chronic knee pain due to chondromalacia, osteoarthritis, fractures, or biomechanical pressure against the lateral femoral condyle. It is situated intra-articular, close to the lateral femoral condyle, the lateral gastrocnemius head tendon, and the fabellofibular ligament. Given its rarity, the diagnosis of a symptomatic fabella is often overlooked when evaluating patients with persistent posterolateral knee pain...
April 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28580253/arthroscopic-patellar-lateral-facetectomy
#9
Marcio B Ferrari, George Sanchez, Jorge Chahla, Gilbert Moatshe, Robert F LaPrade
Isolated patellofemoral osteoarthritis is relatively prevalent, with the lateral facet of the patella being the most commonly affected portion. This pathology can be a result of a patellar maltracking syndrome, patella instability, or idiopathic degenerative changes. A thorough diagnostic work-up with a physical examination and imaging studies are mandatory for a proper diagnosis and to rule out other causes of patellofemoral knee pain. These patients are often treated nonoperatively with exercises for patella mobility, intra-articular injections, braces, patellar tracking, quadriceps balance and strength, and activity modification...
April 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28580251/multiligament-reconstruction-of-the-knee-in-the-setting-of-knee-dislocation-with-a-medial-sided-injury
#10
Marcio B Ferrari, Jorge Chahla, Justin J Mitchell, Gilbert Moatshe, Jacob D Mikula, Daniel Cole Marchetti, Robert F LaPrade
Multiple ligament knee injuries are complex pathologies that often result from traumatic knee dislocations. Both a high level of suspicion and a thorough clinical and radiographic examination are mandatory to diagnose and identify all injured structures. Reconstruction of all injured ligaments is recommended to aid in early mobilization and to avoid joint stiffness or graft failure. For knee dislocations involving injury to the anterior cruciate ligament, posterior cruciate ligament, and medial-sided structures, a repair and augmentation of the medial collateral ligament, together with an anatomic reconstruction of the anterior cruciate ligament and double-bundle posterior cruciate ligament, is recommended...
April 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28580247/repair-of-proximal-hamstring-tears-a-surgical-technique
#11
Gilbert Moatshe, Jorge Chahla, Alexander R Vap, Marcio Ferrari, George Sanchez, Justin J Mitchell, Robert F LaPrade
Proximal hamstring tears are among the most common sports-related injuries. These injuries often occur as strains or partial tears at the proximal muscle belly or the musculotendinous junction, with avulsion injuries of the proximal attachment occurring less frequently. Regardless of the mechanism, they produce functional impairment and negatively affect an athlete's performance. Various classifications for these injuries are reported in the literature. Early surgical treatment is recommended for patients with either a 2-tendon tear/avulsion with more than 2 cm retraction or those with complete 3-tendon tears...
April 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28577706/biologic-options-for-articular-cartilage-wear-platelet-rich-plasma-stem-cells-bone-marrow-aspirate-concentrate
#12
REVIEW
Matthew J Kraeutler, Jorge Chahla, Robert F LaPrade, Cecilia Pascual-Garrido
Biological treatments for articular cartilage repair have gained in popularity in the past decade. Advantages of these therapies include minimal invasiveness, improved healing time, and faster recovery. Biological therapies for cartilage repair include platelet-rich plasma, bone marrow aspirate concentrate, and cell-based therapies. These methods have the added benefit of containing growth factors and/or stem cells that aid in recovery and regeneration. The purpose of this article is to review the current cartilage treatment options and the existing literature on outcomes, complications, and safety profile of these products for use in the knee and hip joints...
July 2017: Clinics in Sports Medicine
https://www.readbyqxmd.com/read/28510478/two-tunnel-transtibial-repair-of-radial-meniscus-tears-produces-comparable-results-to-inside-out-repair-of-vertical-meniscus-tears
#13
Mark E Cinque, Andrew G Geeslin, Jorge Chahla, Grant J Dornan, Robert F LaPrade
BACKGROUND: Radial meniscus tears disrupt the circumferential fibers and thereby compromise meniscus integrity. Historically, radial tears were often treated with meniscectomy because of an incomplete understanding of the biomechanical consequences of these tears, limited information regarding the biomechanical performance of repair, and the technical difficulty associated with repair. There is a paucity of studies on the outcomes of the repair of radial meniscus tears. Purpose/Hypothesis: The purpose was to determine the outcomes of 2-tunnel transtibial repair of radial meniscus tears and compare these results to the outcomes of patients who underwent the repair of vertical meniscus tears with a minimum of 2-year follow-up...
May 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28509821/minimum-information-for-studies-evaluating-biologics-in-orthopaedics-mibo-platelet-rich-plasma-and-mesenchymal-stem-cells
#14
Iain R Murray, Andrew G Geeslin, Ewan B Goudie, Frank A Petrigliano, Robert F LaPrade
BACKGROUND: A comprehensive approach to the evaluation of biologic therapies for musculoskeletal conditions is required to guide appropriate future use. Clinical studies evaluating platelet-rich plasma (PRP) and mesenchymal stem cells (MSCs) are limited by inadequate reporting of scientific details critical to outcome. We developed minimum reporting requirements for clinical studies evaluating PRP and MSCs using Delphi consensus methods. METHODS: The need for consensus on the minimum reporting requirements for studies evaluating biologics was identified at the American Academy of Orthopaedic Surgeons/Orthopaedic Research Society (AAOS/ORS) Biologic Treatments for Orthopaedic Injuries Symposium in 2015 and the American Orthopaedic Society for Sports Medicine (AOSSM) Biologic Treatments for Sports Injuries II Think Tank in 2015...
May 17, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28508006/early-osteoarthritis-after-untreated-anterior-meniscal-root-tears-an-in-vivo-animal-study
#15
Brett D Steineman, Robert F LaPrade, Kelly S Santangelo, Brent T Warner, Laurie R Goodrich, Tammy L Haut Donahue
BACKGROUND: Meniscal root tears cause menisci and their insertions to inadequately distribute loads and potentially leave underlying articular cartilage unprotected. Untreated meniscal root tears are becoming increasingly recognized to induce joint degradation; however, little information is known about anterior meniscal root tears and how they affect joint tissue. PURPOSE: To observe the early degenerative changes within the synovial fluid, menisci, tibial articular cartilage, and subchondral bone after arthroscopic creation of untreated anterior meniscal root tears...
April 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28502387/anterolateral-ligament-reconstruction-techniques-biomechanics-and-clinical-outcomes-a-systematic-review
#16
REVIEW
Nicholas N DePhillipo, Mark E Cinque, Jorge Chahla, Andrew G Geeslin, Robert F LaPrade
PURPOSE: To perform a systematic review of the described anterolateral ligament (ALL) reconstruction techniques, biomechanical performance, and clinical outcomes of ALL reconstruction in the setting of concurrent anterior cruciate ligament (ACL) reconstruction. METHODS: A systematic review was performed according to PRISMA guidelines using the Cochrane Database of Systematic Reviews, the Cochrane Central Register of Controlled Trials, PubMed, MEDLINE, and Embase, from 1980 to present...
May 11, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28501222/medial-patellar-instability-a-systematic-review-of-the-literature-of-outcomes-after-surgical-treatment
#17
REVIEW
Gilbert Moatshe, Mark E Cinque, Bradley M Kruckeberg, Jorge Chahla, Robert F LaPrade
PURPOSE: To perform a systematic review of literature reporting on outcomes after surgical treatment of medial patellar instability. METHODS: A systematic review was performed according to PRISMA guidelines. Inclusion criteria were as follows: the outcomes and complications of medial patellar instability repair with a follow-up greater than 12 months, English language, and human studies. We excluded cadaveric studies, animal studies, basic science articles, editorial articles, review articles, and surveys...
May 10, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28463534/incidence-and-detection-of-meniscal-ramp-lesions-on-magnetic-resonance-imaging-in-patients-with-anterior-cruciate-ligament-reconstruction
#18
Nicholas N DePhillipo, Mark E Cinque, Jorge Chahla, Andrew G Geeslin, Lars Engebretsen, Robert F LaPrade
BACKGROUND: Meniscal ramp lesions have been reported to be present in 9% to 17% of patients undergoing anterior cruciate ligament (ACL) reconstruction. Detection at the time of arthroscopy can be accomplished based on clinical suspicion and careful evaluation. Preoperative assessment via magnetic resonance imaging (MRI) has been reported to have a low sensitivity in identifying meniscal ramp lesions. PURPOSE: To investigate the incidence of meniscal ramp lesions in patients with ACL tears and the sensitivity of preoperative MRI for the detection of ramp lesions...
May 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28451613/medial-patellar-instability-treatment-and-outcomes
#19
Gilbert Moatshe, Tyler R Cram, Jorge Chahla, Mark E Cinque, Jonathan A Godin, Robert F LaPrade
BACKGROUND: Historically, a lateral retinacular release was one of the primary surgical interventions used to treat lateral patellar instability. However, disruption of the lateral structures during this procedure has been associated with medial instability of the patella. HYPOTHESIS: We hypothesize that good to excellent outcomes can be achieved at midterm follow-up after lateral patellotibial ligament reconstruction. STUDY DESIGN: Case series; Level of evidence, 4...
April 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28426251/current-concepts-of-the-anterolateral-ligament-of-the-knee-anatomy-biomechanics-and-reconstruction
#20
Matthew J Kraeutler, K Linnea Welton, Jorge Chahla, Robert F LaPrade, Eric C McCarty
In 1879, Paul Segond described an avulsion fracture (now known as a Segond fracture) at the anterolateral proximal tibia with the presence of a fibrous band at the location of this fracture. Although references to this ligament were occasionally made in the anatomy literature after Segond's discovery, it was not until 2012 that Vincent et al named this ligament what we know it as today, the anterolateral ligament (ALL) of the knee. The ALL originates near the lateral epicondyle of the distal femur and inserts on the proximal tibia near Gerdy's tubercle...
April 1, 2017: American Journal of Sports Medicine
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