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Alka Singh, Rajeshwar Nath Srivastava, Ashok Agrahari, Suruchi Singh, Saloni Raj, Tanushri Chatterji, Abbas Ali Mahdi, Ravindra Kumar Garg, Raja Roy
BACKGROUND: Acute Spinal Cord Injury (ASCI) is still having substantial morbidity and mortality despite of advanced therapeutics. Major obstacles are paucity of monitoring tools or biomarkers for severity determination, recovery and prognostication. A prospective case control pilot study with serum 1 H NMR spectroscopic metabolic profiling was carried out to evaluate metabolites perturbations and its relationship with recovery and to see role of stem cells in facilitating neurological recovery...
February 14, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
Ranbir Singh, Sanjaykumar R Suranagi, Jaewon Lee, Hansol Lee, Min Kim, Kilwon Cho
Herein we report a comparative morphological analysis of the perylene diimide (PDI)- and fullerene-based organic solar cells (OSCs) to identify the factors responsible for low performance of PDI-based devices. A PDI derivative, bis-PDI, and a fullerene derivative, PC70BM, are mixed with an efficient polymer donor, PffBT4T-2OD. The large disparity in power conversion efficiencies (PCEs) of OSCs composed of PffBT4T-2OD:bis-PDI (PCE = 5.18%) and PffBT4T-2OD:PC70BM (PCE = 10.19%) observed are attributed to differences in the nanostructural motif of bulk heterojunction (BHJ) morphologies of these blend systems...
February 12, 2018: Scientific Reports
Liming Zhang, Ping Guan, Zhihan Zhang, Yujie Dai, Limin Hao
Complexes of amylose (Am) with garlic bioactive components (GBCs) were prepared by milling activating treatment of Am and garlic paste (GP) together. The complex, produced by milling for 2.5h with the garlic (dry basis)/Am ratio of 1:5 (w/w) and water content of 25% (w/w) exhibited significantly higher allicin content (0.49mg/g of complex) than others. The scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transforms infrared (FT-IR), differential scanning calorimetry (DSC), thermogravimetry analysis (TGA), high performance liquid chromatography (HPLC), and gas chromatography-mass spectrometry (GC-MS) techniques were used complex characterization...
March 2018: Food Research International
Diana E Kornbrot, Richard Wiseman, George J Georgiou
The quality of psychological studies is currently a major concern. The Many Labs Project (MLP) and the Open-Science-Collaboration (OSC) have collected key data on replicability and statistical effect sizes. We build on this work by investigating the role played by three measurement types: ratings, proportions and unbounded (measures without conceptual upper limits, e.g. time). Both replicability and effect sizes are dependent on the amount of variability due to extraneous factors. We predicted that the role of such extraneous factors might depend on measurement type, and would be greatest for ratings, intermediate for proportions and least for unbounded...
2018: PloS One
Anita N Jacobson, Jeffrey P Bratberg, Miranda Monk, John Ferrentino
BACKGROUND: Overdose education and naloxone training was recently implemented into the required curriculum of the College of Pharmacy at the University of Rhode Island. The objective of this study was to compare the retention of knowledge between student pharmacists who received a didactic lecture only versus student pharmacists who received the same lecture plus a skills-based objective structured clinical examination (OSCE) with a standardized patient actor. METHODS: Students in their first-professional year (P1) of the Doctor of Pharmacy program (n = 129) and students in their second-professional (P2) year (n = 123) attended a required lecture on opioid overdose, including detailed naloxone training...
February 12, 2018: Substance Abuse
Gonzalo De Luna, Brigitte Ranque, Marie Courbebaisse, Jean-Antoine Ribeil, Djamal Khimoud, Sidonie Dupeux, Jonathan Silvera, Lucile Offredo, Jacques Pouchot, Jean-Benoît Arlet
BACKGROUND: Osteosclerosis (OSC) is a rarely studied complication of sickle cell disease (SCD). The objective of our study was to determine the prevalence and characteristics of high bone mineral density (BMD) and its radiological features in adult SCD patients. METHODS: This prospective observational study was conducted from May 2007 to May 2016 in consecutive patients with steady-state SCD at two university hospitals. The BMD of the lumbar spine (L1-L4) and right femoral neck was determined by dual energy X-ray absorptiometry...
February 8, 2018: Bone
H Barrett Fromme, Michael S Ryan, Alix Darden, Donna D'Alessandro, Leora Mogilner, Steven Paik, Teri L Turner
Education, like clinical medicine, should be based on the most current evidence in the field. Unfortunately, medical educators can be overwhelmed by the sheer volume and range of resources for this literature. This article provides an overview of 15 articles from 2016 that the authors consider the top articles in the field of pediatric medical education. The seven authors, all medical educators with combined leadership and expertise across the continuum of pediatric medical education, used an interative, three-stage process to review more than 6339 abstracts published in 2016...
February 6, 2018: Academic Pediatrics
Han Ju, Jian Zhang, Zhuosen Sun, Zheng Huang, Wenbao Qi, Bing Huang, Peng Zhan, Xinyong Liu
Inspired by our initial discovery about a series of neuraminidase (NA) inhibitors targeting the 150-cavity, in present study, we designed, synthesized, and biologically tested a panel of novel oseltamivir derivatives with C-1 modification, targeting the 430-cavity, an additional binding site which widely and stably existed in both group-1 and group-2 NAs. Some of the synthesized compounds displayed robust anti-influenza potencies against H5N1 and H5N6 viruses. Among them, compound 8b exerted the greatest inhibition, with IC50 values of 0...
February 1, 2018: European Journal of Medicinal Chemistry
Zhihui Liao, Yilin Wang, Yongkang An, Yun Tan, Xiangchuang Meng, Feiyan Wu, Lie Chen, Yiwang Chen
Main chain donor and side chain acceptor (D-s-A) copolymers are an important branch of the D-A copolymer family. However, the development of D-s-A copolymers significantly falls behind the alternative D-A copolymers, especially for organic solar cells, because a breakthrough in device performance is not yet obtained with a reported power conversion efficiency (PCE) of 2%-4%. Herein, a newly developed D-s-A copolymer PDRCNBDT, bearing 2-(1, 1-dicyanomethylene) rhodanine pendant group as the donor material, delivers a high PCE of 5...
February 5, 2018: Macromolecular Rapid Communications
Zitong Wu, Xiaodong Wang, Jingjing Yu, Huangjian Yi, Xiaowei He
Fluorescence molecular tomography (FMT) is an important in vivo molecular imaging technique and has been widely studied in preclinical research. Many methods perform well in the reconstruction of a single fluorescent target but may fail in reconstructing multiple targets because of the severe ill-posedness of the FMT inverse problem. In this paper the original synchronization-inspired clustering algorithm (OSC) is introduced into FMT for resolving multiple targets from the reconstruction result. Based on OSC, a synchronization-based clustering algorithm for FMT (SC-FMT) is developed to further improve location accuracy...
February 1, 2018: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
Núria Obradors-Rial, Carles Ariza, Luis Rajmil, Carles Muntaner
OBJECTIVES: To compare different measures of socioeconomic position (SEP) and occupational social class (OSC) and to evaluate their association with risky alcohol consumption among adolescents attending the last mandatory secondary school (ages 15-17 years). METHODS: This was a cross-sectional study. 1268 adolescents in Catalonia (Spain) participated in the study. Family affluence scale (FAS), parents' OSC, parents' level of education and monthly familiar income were used to compare socioeconomic indicators...
February 2, 2018: International Journal of Public Health
Marianna D LaNoue, Debra L Roter
OBJECTIVE: To explore the relationships between self-reported Empathy and the patient-centered communication patterns of physician trainees. METHODS: "Eighty-four 3rd year medical students completed the Jefferson Scale of Empathy (JSE - student version) and had recordings of a single OSCE analyzed using the Roter Interactional Analysis System (RIAS). Correlation and regression were employed to explore the relationships among JSE total score, 3 JSE subscales, 10 composite codes of provider communication, and a summary 'patient centered communication' ratio, reflecting the balance of psychosocial and emotional to biomedical communication of the simulated patient and student...
January 29, 2018: Patient Education and Counseling
Ming Lee, Michelle Vermillion
BACKGROUND: Multiple undergraduate achievements have been used for graduate admission consideration. Their relative values in the prediction of residency performance are not clear. This study compared the contributions of major undergraduate assessments to the prediction of internship performance. METHODS: Internship performance ratings of the graduates of a medical school were collected from 2012 to 2015. Hierarchical multiple regression analyses were used to examine the predictive values of undergraduate measures assessing basic and clinical sciences knowledge and clinical performances, after controlling for differences in the Medical College Admission Test (MCAT)...
February 1, 2018: Medical Teacher
Logan W Carr, Brad Morrow, Brett Michelotti, Randy M Hauck
BACKGROUND: The increased efficiency and cost savings have led many surgeons to move their practice away from the traditional operating room (OR) or outpatient surgery center (OSC) and into the clinic setting. With the cost of health care continuing to rise, the venue with the lowest cost should be utilized. We performed a direct cost analysis of a single surgeon performing an open carpal tunnel release in the OR, OSC, and clinic. METHODS: Four treatment groups were prospectively studied: the hospital OR with monitored anesthesia care (OR-MAC), OSC with MAC (OSC-MAC), OSC with local anesthesia (OSC-local), and clinic with local anesthesia (clinic)...
January 1, 2018: Hand: Official Journal of the American Association for Hand Surgery
Xinping Duan, Zhaojun Wen, Yuxin Zhao, Junfu Zhou, Huihuang Fang, Yanning Cao, Lilong Jiang, Linmin Ye, Youzhu Yuan
Heterogeneous catalytic oxidation arises from the prerequisite oxygen activation and transfer ability of metal oxide catalysts. Thus, engineering intercalated nanounits and heterophase metal oxide structures, and forming interstitial catalyst supports at the nanoscale level can drastically alter the catalytic performances of metal oxides. This is particularly important for ceria-based nanomaterial catalysts, where the interactions of reducible ceria (CeO2) and nonreducible oxides are fundamental for the preparation of enhanced catalysts for oxygen-involved reactions...
January 31, 2018: Nanoscale
John D Mitchell, Rabia Amir, Mario Montealegre-Gallegos, Feroze Mahmood, Marc Shnider, Azad Mashari, Lu Yeh, Ruma Bose, Vanessa Wong, Philip Hess, Yannis Amador, Jelliffe Jeganathan, Stephanie B Jones, Robina Matyal
While standardized examinations and data from simulators and phantom models can assess knowledge and manual skills for ultrasound, an Objective Structured Clinical Examination (OSCE) could assess workflow understanding. We recruited 8 experts to develop an OSCE to assess workflow understanding in perioperative ultrasound. The experts used a binary grading system to score 19 graduating anesthesia residents at 6 stations. Overall average performance was 86.2%, and 3 stations had an acceptable internal reliability (Kuder-Richardson formula 20 coefficient >0...
January 29, 2018: Anesthesia and Analgesia
Mehdi Aloosh, Félix Couture, Nader Fahmy, Mostafa M Elhilali, Sero Andonian
INTRODUCTION: We aimed to assess flexible ureteroscopic stone extraction skill of urology postgraduate trainees (PGTs) at an Objective Structured Clinical Examination (OSCE) and to determine whether previous experience in the operating theatre or practice on the simulator correlated with performance. METHODS: After obtaining ethics approval, PGTs from postgraduate years (PGYs) 3-5 were recruited from all four Quebec urology training programs during an OSCE. After a short orientation to the UroMentor™ simulator, PGTs were asked to perform Task 10 for 15 minutes, where two small stones from the left proximal ureter and renal pelvis were extracted using a basket...
December 1, 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
Zhaoyang Yao, Xunfan Liao, Ke Gao, Francis Lin, Xiaobao Xu, Xueliang Shi, Lijian Zuo, Feng Liu, Yiwang Chen, Alex K-Y Jen
Two cheliform non-fullerene acceptors, DTPC-IC and DTPC-DFIC based on a highly electron-rich core dithienopicenocarbazole (DTPC) are synthesized, showing ultra-narrow bandgaps (as low as 1.21 eV). The two-dimensional nitrogen-containing conjugated DTPC possesses strong electron-donating capability, which induces intense intramolecular charge transfer and intermolecular π-π stacking in derived acceptors. The solar cell based on DTPC-DFIC and a spectral-complementary polymer donor PTB7-Th showed a high power conversion efficiency of 10...
January 29, 2018: Journal of the American Chemical Society
Xiaohan Wu, Shun Mao, Junhong Chen, Jia Huang
Organic semiconductors (OSCs) have been extensively studied as sensing channel materials in field-effect transistors due to their unique charge transport properties. Stimulation caused by its environmental conditions can readily change the charge-carrier density and mobility of OSCs. Organic field-effect transistors (OFETs) can act as both signal transducers and signal amplifiers, which greatly simplifies the device structure. Over the past decades, various sensors based on OFETs have been developed, including physical sensors, chemical sensors, biosensors, and integrated sensor arrays with advanced functionalities...
January 29, 2018: Advanced Materials
Marco Marelli, Simona Amenta
Orthography-semantics consistency (OSC) is a measure that quantifies the degree of semantic relatedness between a word and its orthographic relatives. OSC is computed as the frequency-weighted average semantic similarity between the meaning of a given word and the meanings of all the words containing that very same orthographic string, as captured by distributional semantic models. We present a resource including optimized estimates of OSC for 15,017 English words. In a series of analyses, we provide a progressive optimization of the OSC variable...
January 25, 2018: Behavior Research Methods
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