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https://www.readbyqxmd.com/read/29925005/piwi-nuclear-localization-and-its-regulatory-mechanism-in-drosophila-ovarian-somatic-cells
#1
Ryu Yashiro, Yukiko Murota, Kazumichi M Nishida, Haruna Yamashiro, Kaede Fujii, Asuka Ogai, Soichiro Yamanaka, Lumi Negishi, Haruhiko Siomi, Mikiko C Siomi
In Drosophila ovarian somatic cells (OSCs), Piwi represses transposons transcriptionally to maintain genome integrity. Piwi nuclear localization requires the N terminus and PIWI-interacting RNA (piRNA) loading of Piwi. However, the underlying mechanism remains unknown. Here, we show that Importinα (Impα) plays a pivotal role in Piwi nuclear localization and that Piwi has a bipartite nuclear localization signal (NLS). Impα2 and Impα3 are highly expressed in OSCs, whereas Impα1 is the least expressed. Loss of Impα2 or Impα3 forces Piwi to be cytoplasmic, which is rectified by overexpression of any Impα members...
June 19, 2018: Cell Reports
https://www.readbyqxmd.com/read/29917193/microrna-200c-suppresses-tumor-metastasis-in-oral-squamous-carcinoma-by-inhibiting-epithelial-mesenchymal-transition
#2
N-N Xie, Z-X Liu, C Wu, P-L Wang, G-T Song, Z Chen
OBJECTIVE: To examine the potential mechanisms implicating miR-200c and epithelial-mesenchymal transition (EMT) in oral squamous carcinoma (OSC). MATERIALS AND METHODS: 32 pairs of OSC tissue samples and matched para-carcinoma normal tissue from patients undergoing routine surgery in the Xuzhou Stomatological Hospital from 2014-2016. HOC313 cells were cultured and transfected with miR-200c mimics and scrambled mimics. Cell migration, invasion assays, Luciferase reporter assay, and Western blot assay were conducted...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29914441/peers-versus-professional-training-of-basic-life-support-in-syria-a-randomized-controlled-trial
#3
Fatima Abbas, Bisher Sawaf, Ibrahem Hanafi, Mohammad Younis Hajeer, Mhd Ismael Zakaria, Wafaa Abbas, Fadi Alabdeh, Nazir Ibrahim
BACKGROUND: Peer training has been identified as a useful tool for delivering undergraduate training in basic life support (BLS) which is fundamental as an initial response in cases of emergency. This study aimed to (1) Evaluate the efficacy of peer-led model in basic life support training among medical students in their first three years of study, compared to professional-led training and (2) To assess the efficacy of the course program and students' satisfaction of peer-led training...
June 18, 2018: BMC Medical Education
https://www.readbyqxmd.com/read/29913119/effect-of-tak1-on-osteogenic-differentiation-of-mesenchymal-stem-cells-by-regulating-bmp-2-via-wnt-%C3%AE-catenin-and-mapk-pathway
#4
Hongpeng Yang, Yue Guo, Dawei Wang, Xiaofei Yang, Chengzhi Ha
Mesenchymal stem cells (MSCs) have the ability to differentiate into osteoblasts and chondrocytes. In vitro osteogenic differentiation is critical but the molecular mechanism has yet to be further clarified. The role of TGF-β activated kinase 1 (TAK1) in MSCs osteogenesis differentiation has not been reported. By adding si-TAK1 and rhTAK1, the osteogenic differentiation of MSCs was measured. Expression levels of the osteoblastic marker genes during osteogenic differentiation of MSCs were checked. As well as molecules involved in BMP and Wnt/β-catenin signaling pathways...
January 2, 2018: Organogenesis
https://www.readbyqxmd.com/read/29911382/quinoxaline-based-wide-band-gap-polymers-for-efficient-non-fullerene-organic-solar-cells-with-large-open-circuit-voltages
#5
Jie Yang, Mohammad Afsar Uddin, Yumin Tang, Yulun Wang, Yang Wang, Huimin Su, Rutian Gao, Zhi-Kuan Chen, Junfeng Dai, Han Young Woo, Xugang Guo
We present here a series of wide band gap (Eg: > 1.8 eV) polymer donors by incorporating thiophene-flanked phenylene as electron-donating unit and quinoxaline as electron-accepting co-unit to attain large open-circuit voltages (Vocs) and short-circuit currents (Jscs) in non-fullerene organic solar cells (OSCs). Fluorination was utilized to fine-tailor the energetics of polymer frontier molecular orbitals (FMOs) by replacing a variable number of H atoms on the phenylene moiety with F. It was found that fluorination can effectively modulate polymer backbone planarity through intramolecular noncovalent S…F and/or H…F interactions...
June 18, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29904283/melt-processing-of-small-molecule-organic-photovoltaics-via-bulk-heterojunction-compatibilization
#6
Aiman Rahmanudin, Liang Yao, Xavier A Jeanbourquin, Yongpeng Liu, Arvindh Sekar, Emilie Ripaud, Kevin Sivula
Melt-processing of organic semiconductors (OSCs) is a promising environmentally-friendly technique that can alleviate dependence on toxic chlorinated solvents. While melt-processed single-component OSC devices ( e.g. field-effect-transistors) have been demonstrated, multi-component bulk heterojunctions (BHJs) for organic photovoltaics (OPVs) remain a challenge. Herein, we demonstrate a strategy that affords tunable BHJ phase segregation and domain sizes from a single-phase homogeneous melt by employing strongly-crystalline small-molecule OSCs together with a customized molecular compatibilizing (MCP) additive...
May 21, 2018: Green Chemistry: An International Journal and Green Chemistry Resource: GC
https://www.readbyqxmd.com/read/29903050/self-assessment-differences-between-genders-in-a-low-stakes-objective-structured-clinical-examination-osce
#7
Lorenzo Madrazo, Claire B Lee, Meghan McConnell, Karima Khamisa
OBJECTIVE: Physicians and medical students are generally poor-self assessors. Research suggests that this inaccuracy in self-assessment differs by gender among medical students whereby females underestimate their performance compared to their male counterparts. However, whether this gender difference in self-assessment is observable in low-stakes scenarios remains unclear. Our study's objective was to determine whether self-assessment differed between male and female medical students when compared to peer-assessment in a low-stakes objective structured clinical examination...
June 15, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29901685/investigating-the-influence-of-charge-transport-on-the-performance-of-ptb7-pc-71-bm-based-organic-solar-cells
#8
Mihirsinh Chauhan, Abhishek Sharma, Jessica Patel, M Aatif, Suresh Chand, Manoj Kumar Pandey, Manoj Kumar, J P Tiwari, Brijesh Tripathi
A key challenge for researchers in the field of organic solar cells (OSCs) is to develop a physical model for a device that correctly describes the charge carrier transport phenomenon. In this article, an analytical study on the charge carrier transport phenomenon in an OSC is reported, which expresses a balance between free charge carrier generation and recombination in low mobility PTB7:PC71BM blend layers. First, the current density-voltage (J-V) data for the fabricated OSC were extracted from experiments by varying the incident power light intensity (IPL) and then analysis through theoretical simulation was used to quantify the dominant interface recombination parameters limiting the device's performance...
June 14, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29896684/selection-of-reliable-reference-genes-for-rt-qpcr-during-methyl-jasmonate-salicylic-acid-and-hydrogen-peroxide-treatments-in-ganoderma-lucidum
#9
Xiaoxiao Lu, Yongzhi Liu, Linchao Zhao, Yongnan Liu, Mingwen Zhao
This study aimed to identify suitable reference genes under three chemical inducers, methyl jasmonate (MeJA), salicylic acid (SA) and hydrogen peroxide (H2 O2 ) in Ganoderma lucidum. In this study, expression stabilities of 14 candidate reference genes had been validated. Four algorithms were used: geNorm, NormFinder, BestKeeper, and RefFinder. Our results showed that, in short time, UCE2 (ubiquitin conjugating enzyme) was the most stable gene both in MeJA and H2 O2 treatments, ACTIN (beta-actin) was the most suitable reference gene for SA treatment...
June 12, 2018: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/29892389/a-helical-perylene-diimide-based-acceptor-for-non-fullerene-organic-solar-cells-synthesis-morphology-and-exciton-dynamics
#10
Li Chen, Mingliang Wu, Guangwei Shao, Jiahua Hu, Guiying He, Tongle Bu, Jian-Peng Yi, Jianlong Xia
Helical perylene diimide-based (hPDI) acceptors have been established as one of the most promising candidates for non-fullerene organic solar cells (OSCs). In this work, we report a novel hPDI-based molecule, hPDI2 -CN2 , as an electron acceptor for OSCs. Combining the hPDI2 -CN2 with a low-bandgap polymeric donor (PTB7-Th), the blending film morphology exhibited high sensitivity to various treatments (such as thermal annealing and addition of solvent additives), as evidenced by atomic force microscope studies...
May 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29890371/mitigating-the-challenges-of-objective-structured-clinical-examination-osce-in-nursing-education-a-phenomenological-research-study
#11
Cordelia Obizoba
BACKGROUND: Objective evaluation of clinical competencies is a key component of undergraduate nursing education programs. Objective Structured Clinical Examination (OSCE), widely used in nursing education internationally has limited utilization in undergraduate nursing programs in the United States. The efficacy of OSCE as a valuable method of objective evaluation of students' clinical competencies is not so much the problem for the nursing faculty; overcoming the impediments of its implementation is a much greater challenge...
June 6, 2018: Nurse Education Today
https://www.readbyqxmd.com/read/29888728/determinants-of-outcome-of-final-undergraduate-surgery-examinations-in-a-nigerian-university
#12
O Onwuasoigwe, E E Onyia, M Mesi
Background: Medical students' assessment is an important aspect of medical undergraduate training that requires periodic review to achieve objectivity and improve training. We reviewed the outcome and factors that influenced outcome of undergraduate students' final surgery examination. Materials and Methods: Final examination records of undergraduate medical students in surgery from a single institution for 5 years (2013-2017) were retrospectively reviewed. Scores of the students in continuous assessments (CA), multiple-choice questions (MCQs), essays, long case, short cases, orals, and objective structured clinical examinations (OSCE) were extracted as appropriate...
June 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29888443/small-molecule-based-non-fullerene-acceptors-a-comparative-study
#13
REVIEW
Yuvraj Patil, Rajneesh Misra
Organic solar cells (OSCs) have gained attention of the scientific community from the last decade and are now considered as one of the most important source for low-cost power production. The recent rapid progress in non-fullerene acceptors in BHJ indicates that they have potential to compete with fullerene-based BHJ OSCs. The present review addressed the systematic comparison among various acceptors (diketopyrrolopyrrole (DPP), benzothiadiazole (BTD) and perylenediimide (PDI) based acceptors) in order to design and improve the performance of small molecules based non-fullerene acceptors...
June 10, 2018: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/29882281/teaching-and-evaluation-of-basic-urodynamic-skills-in-urology-residency-programs-randomized-controlled-study
#14
Samer Shamout, Sero Andonian, Hani Kabbara, Jacques Corcos, Lysanne Campeau
AIMS: Considering the growing role of urodynamic studies (UDS) in urology, we aimed to determine the most effective teaching method with objective evaluation for urodynamic skills, to improve training and patient care. METHODS: Urology residents (n = 20) post-graduate years 3-5 were randomized to receive either a UDS video training module or a standard UDS teaching document one week prior to an objective structured clinical examination (OSCE). The OSCE was a validated visual recognition exam with interpretation of 12 UDS tracing scenarios...
June 8, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29879301/unpacking-the-dark-variance-of-differential-attainment-on-examinations-in-overseas-graduates
#15
Fiona Patterson, Paul A Tiffin, Safiatu Lopes, Lara Zibarras
CONTEXT: Differential performance in postgraduate examinations between home medical graduates and those who qualified outside their country of practice is well recognised. This difference is especially marked in the practical component of the UK Membership of the Royal College of General Practitioners (MRCGP) examination. The potential causes of such disparities are not well understood. METHODS: Data were available for 1874 international medical graduates who applied for general practice (GP) specialty training in the UK in 2008-2012...
July 2018: Medical Education
https://www.readbyqxmd.com/read/29877342/precision-of-polarimetric-orthogonal-state-contrast-estimation-in-coherent-images-corrupted-by-speckle-poisson-and-additive-noise
#16
Jan Dupont, Matthieu Boffety, François Goudail
We consider laser-illuminated active polarimetric imaging systems that measure the orthogonal state contrast (OSC), a frequently used surrogate to the degree of polarization, that can be used, for example, to discriminate manmade objects from natural backgrounds in remote sensing. We investigate the estimation precision of the OSC parameter in the presence of speckle, Poisson, and additive noise by using the Cramer-Rao lower bound (CRLB). Using Monte Carlo simulations and optical experiments, we show that the expression of the CRLB models the actual OSC estimation performance with excellent accuracy...
June 1, 2018: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29871662/mr-findings-of-primary-ovarian-granulosa-cell-tumor-with-focus-on-the-differentiation-with-other-ovarian-sex-cord-stromal-tumors
#17
He Zhang, Hongyu Zhang, Shouxin Gu, Yanyu Zhang, Xuefen Liu, Guofu Zhang
BACKGROUND: To describe magnetic resonance imaging (MRI) features of ovarian granulosa cell tumors (OGCTs) and compare with other sex cord-stromal tumors (OSCs) in ovary. METHODS: MR findings of 18 patients with surgically confirmed ovarian granulosa cell tumor were retrospectively reviewed by two radiologists with consensus reading. All MR examinations were prospectively performed within one month. Clinical and imaging characteristics of OGCTs were evaluated and compared with OSCs (control group)...
June 5, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29870337/identifying-functional-modules-in-co-regulatory-networks-through-overlapping-spectral-clustering
#18
Jiawei Luo, Ying Yin, Chu Pan, Gen Xiang, Nguyen Hoang Tu
At the co-regulatory network level, functional modules comprising microRNAs (miRNAs), transcription factors (TFs), and common target genes (mRNAs) are found to be widespread in diverse organisms from bacteria to human, suggesting that co-regulatory functional modules (CRMs) serve as basic building blocks of transcription networks. Identification of CRMs would contribute to explore the miRNAs and TFs regulatory mechanism to specific cancer. However, few studies considered the functional modules which contain TFs and overlapping parts now...
April 2018: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/29867061/co-oxidation-at-20-%C3%A2-c-on-au-catalysts-supported-on-mesoporous-silica-effects-of-support-structural-properties-and-modifiers
#19
Abigail Moreno-Martell, Barbara Pawelec, Rufino Nava, Noelia Mota, Luis Escamilla-Perea, Rufino M Navarro, Jose L G Fierro
In this work we report the effects of support structural properties and its modification with some metal oxides modifiers on the catalytic behavior of Au catalysts in the total CO oxidation at 20 °C. Au catalysts were supported on mesoporous silica materials (MSM) having different structural properties: Channel-like (SBA-15), cage-like (SBA-16), hexagonal (HMS), and disordered (DMS-1) structures. The effect of the modifier was evaluated by comparison of the catalytic response of the SBA-15-based catalysts modified with MgO, Fe₂O₃, TiO₂, and CeO₂...
June 4, 2018: Materials
https://www.readbyqxmd.com/read/29864896/therapeutic-efficacy-of-olfactory-stem-cells-in-rotenone-induced-parkinsonism-in-adult-male-albino-rats
#20
Mohammed Abdel-Rahman, Rania A Galhom, Wael Amin Nasr El-Din, Mona H Mohammed Ali, Alaa El-Din Saad Abdel-Hamid
BACKGROUND: Olfactory stem cells (OSCs) are found in the olfactory mucosa and olfactory bulb and have the capacity to proliferate and differentiate along multiple tissue lineages. Rotenone; widely used insecticide has a neurodegenerative effect on the dopaminergic cells of substantia nigra (SN) of midbrain producing Parkinsonism. The aim of this study is to isolate rat OSCs from olfactory mucosa and olfactory bulb, culture these OSCs in suitable medium to allow for their proliferation to be used in the treatment of Parkinsonism induced by rotenone...
July 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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