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https://www.readbyqxmd.com/read/27913082/efficacy-and-feasibility-of-objective-structured-clinical-examination-in-the-internal-assessment-for-surgery-postgraduates
#1
Anitha Muthusami, Subair Mohsina, Sathasivam Sureshkumar, Amaranathan Anandhi, Thirthar Palanivelu Elamurugan, Krishnamachari Srinivasan, Thulasingam Mahalakshmy, Vikram Kate
INTRODUCTION: Traditionally assessment in medical training programs has been through subjective faculty evaluations or multiple choice questions. Conventional examinations provide assessment of the global performance rather than individual competencies thus making the final feedback less meaningful. The objective structured clinical examination (OSCE) is a relatively new multidimensional tool for evaluating training. This study was carried out to determine the efficacy and feasibility of OSCE as a tool for the internal assessment of surgery residents...
November 29, 2016: Journal of Surgical Education
https://www.readbyqxmd.com/read/27906587/differentiation-of-mouse-ovarian-stem-cells-toward-oocyte-like-structure-by-coculture-with-granulosa-cells
#2
Soraya Parvari, Hossein Yazdekhasti, Zahra Rajabi, Valliollah Gerayeli Malek, Tayebeh Rastegar, Mehdi Abbasi
An increasing body of evidence has confirmed existence and function of ovarian stem cells (OSCs). In this study, a novel approach on differentiation of OSCs into oocyte-like cells (OLCs) has been addressed. Recently, different methods have been recruited to isolate and describe aspects of OSCs, but newer and more convenient strategies in isolation are still growing. Herein, a morphology-based method was used to isolate OSCs. Cell suspension of mouse neonatal ovaries was cultured and formed colonies were harvested mechanically and cultivated on mouse embryonic fibroblasts...
November 2016: Cellular Reprogramming
https://www.readbyqxmd.com/read/27901151/improving-the-charge-carrier-transport-of-organic-solar-cells-by-incorporating-a-deep-energy-level-molecule
#3
Chunyu Liu, Zhiqi Li, Zhihui Zhang, Xinyuan Zhang, Liang Shen, Wenbin Guo, Liu Zhang, Yongbing Long, Shengping Ruan
Tetrafluoro-tetracyanoquinodimethane (F4-TCNQ), a strong molecular acceptor, has been proved to be an excellent candidate to achieve the p-type doping effect. When F4-TCNQ is incorporated into a poly(3-hexylthiophene) (P3HT): indene-C60 bisadduct (ICBA) active layer, superior behavior upon inducing polymer donor excited electron transport is demonstrated due to the addition of a deep-lying lowest unoccupied molecular orbital (LUMO) from F4-TCNQ, leading to the realization of organic solar cells (OSCs) with an improved power conversion efficiency (PCE) of 5...
November 30, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27897282/self-assembly-of-partially-fluorinated-hexabenzocoronene-derivatives-in-the-solid-state
#4
Tobias Breuer, Michael Klues, Pauline Liesfeld, Andreas Viertel, Matthias Conrad, Stefan Hecht, Gregor Witte
We report on the synthesis and structural characterization of novel, partially fluorinated hexabenzocoronene (HBC) derivatives. The fluorination of polycyclic aromatic hydrocarbons (PAHs) is a well-established method to enhance the stability of organic semiconductors (OSCs) and render them n-type. For HBC it has been observed that fluorination leads to a modification of the molecular packing motif from a herringbone arrangement to a parallel-packed motif. Here, we study whether this transformation of the molecular packing is also found for the partially fluorinated HBCs 2,5-difluoro-hexa-peri-hexabenzocoronene (F2HBC) and 2,5,8,11-tetrafluoro-peri-hexabenzocoronene (F4HBC)...
November 29, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27897083/hawks-doves-and-rasch-decisions-understanding-the-influence-of-different-cycles-of-an-osce-on-students-scores-using-many-facet-rasch-modeling
#5
Peter Yeates, Stefanie S Sebok-Syer
INTRODUCTION: OSCEs are commonly conducted in multiple cycles (different circuits, times, and locations), yet the potential for students' allocation to different OSCE cycles is rarely considered as a source of variance-perhaps in part because conventional psychometrics provide limited insight. METHODS: We used Many Facet Rasch Modeling (MFRM) to estimate the influence of "examiner cohorts" (the combined influence of the examiners in the cycle to which each student was allocated) on students' scores within a fully nested multi-cycle OSCE...
November 29, 2016: Medical Teacher
https://www.readbyqxmd.com/read/27893952/acceptability-and-impact-of-a-required-palliative-care-rotation-with-prerotation-and-postrotation-observed-simulated-clinical-experience-during-internal-medicine-residency-training-on-primary-palliative-communication-skills
#6
Maxwell T Vergo, Sharona Sachs, Meredith A MacMartin, Kathryn B Kirkland, Amelia M Cullinan, Lisa A Stephens
BACKGROUND: Improving communication training for primary palliative care using a required palliative care rotation for internal medicine (IM) residents has not been assessed. OBJECTIVE: To assess skills acquisition and acceptability for IM residents not selecting an elective. DESIGN: A consecutive, single-arm cohort underwent preobjective structured clinical examination (OSCE) with learner-centric feedback, two weeks of clinical experience, and finally a post-OSCE to crystallize learner-centric take home points...
November 28, 2016: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/27889715/bedside-infant-mannikins-for-teaching-newborn-examination-to-medical-undergraduates
#7
Sheila Samanta Mathai, Deepak Joshi, Mrigank Choubey
BACKGROUND: To study whether using infant mannikins during clinical posting could help in teaching newborn examination to undergraduate medical students. METHODS: 111 final MBBS students were taught newborn examination either by the new method which included practice on infant mannikins at the bedside before examining babies (Group 1) or by the traditional method which involved directly examining babies (Group 2). They were tested the next day by validated, OSCE stations on important aspects of the newborn examination...
November 5, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27887917/microrna-136-inhibits-cancer-stem-cell-activity-and-enhances-the-anti-tumor-effect-of-paclitaxel-against-chemoresistant-ovarian-cancer-cells-by-targeting-notch3
#8
Ju-Yeon Jeong, Haeyoun Kang, Tae Hoen Kim, Gwangil Kim, Jin-Hyung Heo, Ah-Young Kwon, Sewha Kim, Sang-Geun Jung, Hee-Jung An
To identify microRNAs (miRNAs) regulating Notch3 expression in association with paclitaxel resistance, candidate miRNAs targeting Notch3 were predicted using TargetScan. We found that miR-136 directly targets Notch3, and miR-136 was significantly downregulated in OSC tissues relative to normal control tissues, and low expression of miR-136 correlated with poor overall in ovarian cancer patients. Artificial miR-136 overexpression significantly reduced cell viability, proliferation, Cancer stem cell (CSC) spheroid formation, and angiogenesis, and increased apoptosis in paclitaxel-resistant SKpac cells compared with the effects of paclitaxel alone...
November 22, 2016: Cancer Letters
https://www.readbyqxmd.com/read/27887627/epha5-protein-a-potential-marker-for-distinguishing-histological-grade-and-prognosis-in-ovarian-serous-carcinoma
#9
Xiao Chen, Xuan Wang, Xue Wei, Jiandong Wang
BACKGROUND: Ovarian serous carcinoma (OSC) is the most common ovarian epithelial malignancy. Disregulation of Eph/ephrin signaling has been implicated in oncogenesis and tumor progression. EphA5 receptor is one of large families of Eph tyrosine kinase receptor and is documented in the development of nervous system. Till now, there is no published data about the role of EphA5 in ovarian epithelial neoplasmas. METHODS: This study aims to investigate the expression of EphA5 protein in ovarian serous carcinoma, and its relationship to clinical pathological characteristics...
November 25, 2016: Journal of Ovarian Research
https://www.readbyqxmd.com/read/27887620/anatomy-meets-dentistry-linking-anatomy-and-clinical-practice-in-the-preclinical-dental-curriculum
#10
Nicole Rafai, Martin Lemos, Lieven Nils Kennes, Ayichah Hawari, Susanne Gerhardt-Szép, Irmgard Classen-Linke
BACKGROUND: Establishing a strong link early on between preclinical coursework and the clinical context is necessary for students to be able to recognize the practical relevance of the curriculum during their preclinical anatomical courses and to transfer knowledge more easily. Our objective was to enhance the clinical relevance of a preclinical anatomy course for second-year medical students of dentistry by implementing an interdisciplinary skills training course on "Palpation of the Head and Neck Muscles" and to measure the learning outcomes...
November 25, 2016: BMC Medical Education
https://www.readbyqxmd.com/read/27881978/the-oxidosqualene-cyclase-from-the-oomycete-saprolegnia-parasitica-synthesizes-lanosterol-as-a-single-product
#11
Paul Dahlin, Vaibhav Srivastava, Vincent Bulone, Lauren S McKee
The first committed step of sterol biosynthesis is the cyclisation of 2,3-oxidosqualene to form either lanosterol (LA) or cycloartenol (CA). This is catalyzed by an oxidosqualene cyclase (OSC). LA and CA are subsequently converted into various sterols by a series of enzyme reactions. The specificity of the OSC therefore determines the final composition of the end sterols of an organism. Despite the functional importance of OSCs, the determinants of their specificity are not well understood. In sterol-synthesizing oomycetes, recent bioinformatics, and metabolite analysis suggest that LA is produced...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27876220/breaking-bad-news-to-patients-with-cancer-a-randomized-control-trial-of-a-brief-communication-skills-training-module-incorporating-the-stories-and-preferences-of-actual-patients
#12
James Gorniewicz, Michael Floyd, Koyamangalath Krishnan, Thomas W Bishop, Fred Tudiver, Forrest Lang
OBJECTIVE: This study tested the effectiveness of a brief, learner-centered, breaking bad news (BBN) communication skills training module using objective evaluation measures. METHODS: This randomized control study (N=66) compared intervention and control groups of students (n=28) and residents' (n=38) objective structured clinical examination (OSCE) performance of communication skills using Common Ground Assessment and Breaking Bad News measures. RESULTS: Follow-up performance scores of intervention group students improved significantly regarding BBN (colon cancer (CC), p=0...
November 13, 2016: Patient Education and Counseling
https://www.readbyqxmd.com/read/27875999/helping-babies-breathe-hbb-training-what-happens-to-knowledge-and-skills-over-time
#13
Akash Bang, Archana Patel, Roopa Bellad, Peter Gisore, Shivaprasad S Goudar, Fabian Esamai, Edward A Liechty, Sreelatha Meleth, Norman Goco, Susan Niermeyer, William Keenan, Beena D Kamath-Rayne, George A Little, Susan B Clarke, Victoria A Flanagan, Sherri Bucher, Manish Jain, Nilofer Mujawar, Vinita Jain, Janet Rukunga, Niranjana Mahantshetti, Sangappa Dhaded, Manisha Bhandankar, Elizabeth M McClure, Waldemar A Carlo, Linda L Wright, Patricia L Hibberd
BACKGROUND: The first minutes after birth are critical to reducing neonatal mortality. Helping Babies Breathe (HBB) is a simulation-based neonatal resuscitation program for low resource settings. We studied the impact of initial HBB training followed by refresher training on the knowledge and skills of the birth attendants in facilities. METHODS: We conducted HBB trainings in 71 facilities in the NICHD Global Network research sites (Nagpur and Belgaum, India and Eldoret, Kenya), with a 6:1 ratio of facility trainees to Master Trainers (MT)...
November 22, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27875879/guided-ion-beam-and-theoretical-studies-of-the-reactions-of-re-os-and-ir-with-co
#14
JungSoo Kim, Richard M Cox, P B Armentrout
The kinetic-energy dependences of the reactions M(+) + CO where M(+) = Re(+), Os(+), and Ir(+) are studied using guided ion-beam tandem mass spectrometry. Formation of both MO(+) and MC(+) was observed in endothermic processes for all three metals. Modeling of the data provides thresholds that yield 0 K bond dissociation energies (BDEs, in eV) of 4.67 ± 0.09 (Re(+)-O), 4.82 ± 0.14 (Os(+)-O), 4.25 ± 0.11 (Ir(+)-O), 5.13 ± 0.12 (Re(+)-C), 6.14 ± 0.14 (Os(+)-C), and 6.58 ± 0.12 (Ir(+)-C). These BDEs agree well with literature values within experimental uncertainties demonstrating that ground state products are formed for all cases even though some of the reactions are formally spin forbidden...
November 21, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27874020/friedelin-synthase-from-maytenus-ilicifolia-leucine-482-plays-an-essential-role-in-the-production-of-the-most-rearranged-pentacyclic-triterpene
#15
Tatiana M Souza-Moreira, Thaís B Alves, Karina A Pinheiro, Lidiane G Felippe, Gustavo M A De Lima, Tatiana F Watanabe, Cristina C Barbosa, Vânia A F F M Santos, Norberto P Lopes, Sandro R Valentini, Rafael V C Guido, Maysa Furlan, Cleslei F Zanelli
Among the biologically active triterpenes, friedelin has the most-rearranged structure produced by the oxidosqualene cyclases and is the only one containing a cetonic group. In this study, we cloned and functionally characterized friedelin synthase and one cycloartenol synthase from Maytenus ilicifolia (Celastraceae). The complete coding sequences of these 2 genes were cloned from leaf mRNA, and their functions were characterized by heterologous expression in yeast. The cycloartenol synthase sequence is very similar to other known OSCs of this type (approximately 80% identity), although the M...
November 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27873404/the-show-must-go-on-patients-props-and-pedagogy-in-the-theatre-of-the-osce
#16
Gerard J Gormley, Brian D Hodges, Nancy McNaughton, Jennifer L Johnston
 According to Shakespeare, all the world's a stage, and all the men and women merely players. The objective structured clinical examination (OSCE), that most ubiquitous form of assessment in health professions education, offers us a particular instance of this maxim. Comprising at first glance a world of psychometric data, detailed checklists and global rating scales, the OSCE sets out to facilitate the assessment of a candidate's competence in a highly standardised and objective fashion. Despite this clear intention, OSCEs also offer a rich vein of (often unacknowledged) social and cultural processes...
December 2016: Medical Education
https://www.readbyqxmd.com/read/27871725/organic-and-perovskite-solar-cells-working-principles-materials-and-interfaces
#17
REVIEW
Nevena Marinova, Silvia Valero, Juan Luis Delgado
In the last decades organic solar cells (OSCs) have been considered as a promising photovoltaic technology with the potential to provide reasonable power conversion efficiencies combined with low cost and easy processability. Unexpectedly, Perovskite Solar Cells (PSCs) have experienced unprecedented rise in Power Conversion Efficiency (PCE) thus emerging as a highly efficient photovoltaic technology. OSCs and PSCs are two different kind of devices with distinct charge generation mechanism, which however share some similarities in the materials processing, thus standard strategies developed for OSCs are currently being employed in PSCs...
February 15, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27857987/the-comparison-of-the-efficiency-of-traditional-lectures-to-video-supported-lectures-within-the-training-of-the-emergency-medicine-residents
#18
Aydın Sarıhan, Neşe Colak Oray, Birdal Güllüpınar, Sedat Yanturali, Ridvan Atilla, Berna Musal
OBJECTIVES: Recent developments in computer and video technology, multimedia resources enter quickest way possible into medical education and have started to gain popularity. The aim of this study is to evaluate the impact of video-supported lectures on leaning, with comparison to traditional lectures. METHODS: According to lecture techniques, two separate groups; one is the traditional lectures group (TLG) and the other is video-supported lectures group (VSLG), are formed...
September 2016: Turkish Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27856065/associations-of-medical-student-empathy-with-clinical-competence
#19
Rachel S Casas, Ziming Xuan, Angela H Jackson, Lorraine E Stanfield, Nanette C Harvey, Daniel C Chen
OBJECTIVE: Empathy is a crucial skill for medical students that can be difficult to evaluate. We examined if self-reported empathy in medical students was associated with clinical competence. METHODS: This study combined cross-sectional data from four consecutive years of medical students (N=590) from the Boston University School of Medicine. We used regression analysis to evaluate if self-reported empathy (Jefferson Scale of Physician Empathy (JSPE)) predicted scores in clinical clerkships, United States Medical Licensing Examinations, and OBJECTIVE: Structured Clinical Examinations (OSCEs)...
November 10, 2016: Patient Education and Counseling
https://www.readbyqxmd.com/read/27855124/solution-processed-ag-nanowire-zno-nanoparticle-composite-transparent-electrode-for-flexible-organic-solar-cells
#20
Bin Wei, Saihu Pan, Taohong Wang, Zhenghao Tian, Guo Chen, Tao Xu
This paper demonstrates a hybrid transparent electrode composed of a solution-processed silver-nanowire (AgNW) film coated by zinc oxide nanoparticles (ZnO-NPs) acting as a modified buffer layer. The effect of the ZnO-NPs' coating ratio on the performances of indium tin oxide (ITO)-free organic solar cells (OSCs) has been systematically investigated. The optimized ITO-free OSCs achieved a power conversion efficiency (PCE) of 2.85%, while flexible OSCs using the AgNW/ZnO-NP composite transparent electrode grown on a polyethylene terephthalate (PET) substrate showed a PCE of 2...
December 16, 2016: Nanotechnology
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