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https://www.readbyqxmd.com/read/28212527/a-multicenter-phase-ii-study-of-salvage-photodynamic-therapy-using-talaporfin-sodium-me2906-and-a-diode-laser-pnl6405epg-for-local-failure-after-chemoradiotherapy-or-radiotherapy-for-esophageal-cancer
#1
Tomonori Yano, Hiroi Kasai, Takahiro Horimatsu, Kenichi Yoshimura, Satoshi Teramukai, Satoshi Morita, Harue Tada, Yoshinobu Yamamoto, Hiromi Kataoka, Naomi Kakushima, Ryu Ishihara, Hajime Isomoto, Manabu Muto
Photodynamic therapy (PDT) showed promising efficacy for local failure after chemoradiotherapy (CRT) for esophageal cancer. However, PDT required long sun shade period. This study aimed to evaluate the safety and efficacy of PDT using second generation photosensitizer, talaporfin sodium for local failure after CRT. This was the multi-institutional non-randomized phase II study. Patients with histologically proven local failure limited within the muscularis propria after 50Gy or more radiotherapy (RT) for esophageal cancer were eligible...
December 20, 2016: Oncotarget
https://www.readbyqxmd.com/read/28212098/a-2-5-mw-ch-50-mcps-10-analog-channel-adaptively-biased-read-out-front-end-ic-with-low-intrinsic-timing-resolution-for-single-photon-time-of-flight-pet-applications-with-time-dependent-noise-analysis-in-90-nm-cmos
#2
Hugo Cruz, Hong-Yi Huang, Ching-Hsing Luo, Shuenn-Yuh Lee
This paper presents a 10-channel time-of-flight application-specific integrated circuit (ASIC) for positron emission tomography in a 90 nm standard CMOS process. To overcome variations in channel-to-channel timing resolution caused by mismatch and process variations, adaptive biases and a digital-to-analog converter (DAC) are utilized. The main contributions of this work are as follows. First, multistage architectures reduce the total power consumption, and detection bandwidths of analog preamplifiers and comparators are increased to 1 and 1...
February 13, 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28210387/efficacy-of-a-low-fluence-high-repetition-rate-810nm-diode-laser-for-permanent-hair-reduction-in-indian-patients-with-skin-types-iv-vi
#3
Madhuri Agarwal, Sangeeta Velaskar, Michael H Gold
Background: The study's aim is to evaluate the novel "in motion" technique for permanent hair removal using a low level fluence/high repetition rate on patients with a dark skin type over different areas of the body. Objectives: To assess fluence, accumulative energy, and number of treatments needed to achieve a significant hair reduction and patient satisfaction with minimal side effects, low discomfort levels, and high safety profile in a skin type IV-VI Indian patients. Methods: Seventy-one Indian female patients with skin type IV-VI were enrolled in the study...
November 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28210023/application-of-diode-laser-in-the-treatment-of-dentine-hypersensitivity
#4
Mirjana Gojkov-Vukelic, Sanja Hadzic, Amila Zukanovic, Enes Pasic, Veriva Pavlic
INTRODUCTION: Dentine hypersensitivity is characterized by acute, sharp pain arising from the exposed dentine, most commonly in response to thermal, tactile, or chemical stimuli, and which cannot be linked to any other pathological changes in the tooth or the environment. Therapy uses various impregnating agents in the form of solutions or gels and, in more recent times, laser. AIM: The aim of this research was to examine the effects of treatment of hypersensitive dental cervix with diode laser...
December 2016: Medical Archives
https://www.readbyqxmd.com/read/28205144/recommended-best-practices-for-process-monitoring-instrumentation-in-pharmaceutical-freeze-drying-2017
#5
Steven Nail, Serguei Tchessalov, Evgenyi Shalaev, Arnab Ganguly, Ernesto Renzi, Frank Dimarco, Lindsay Wegiel, Steven Ferris, William Kessler, Michael Pikal, Greg Sacha, Alina Alexeenko, T N Thompson, Cindy Reiter, James Searles, Paul Coiteux
Recommended best practices in monitoring of product status during pharmaceutical freeze drying are presented, focusing on methods that apply to both laboratory and production scale. With respect to product temperature measurement, sources of uncertainty associated with any type of measurement probe are discussed, as well as important differences between the two most common types of temperature-measuring instruments-thermocouples and resistance temperature detectors (RTD). Two types of pressure transducers are discussed-thermal conductivity-type gauges and capacitance manometers, with the Pirani gauge being the thermal conductivity-type gauge of choice...
February 15, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28199463/effect-of-methyl-aminolevulinate-photodynamic-therapy-with-and-without-ablative-fractional-laser-treatment-in-patients-with-microinvasive-squamous-cell-carcinoma-a-randomized-clinical-trial
#6
Seung-Hwan Choi, Ki-Ho Kim, Ki-Hoon Song
Importance: Surgical excision is the standard treatment for cutaneous squamous cell carcinoma (SCC). However, microinvasive SCC (Clark level II) is limited to the papillary dermis, and it should be differentiated from invasive SCC. Ablative fractional laser-primed photodynamic therapy (AFL-PDT) may have enhanced efficacy. Objective: To compare 1 session of AFL-PDT with 2 sessions of conventional methyl aminolevulinate-PDT (MAL-PDT) for the treatment of microinvasive SCC...
February 15, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28198878/diode-pumped-mode-locked-tm-luag-laser-at-2%C3%A2-%C3%A2-%C3%AE-m-based-on-gasb-sesam
#7
C Luan, K Yang, J Zhao, S Zhao, T Li, H Zhang, J He, L Song, T Dekorsy, M Guina, L Zheng
Mode-locking of a directly diode-pumped Tm:LuAG laser is demonstrated using GaSb-based semiconductor saturable absorber mirrors (SESAMs). Stable and self-starting mode-locked operation was realized, generating pulses as short as 13.6 ps at 2024 nm with a maximum output power of 98 mW. Two GaInAs-based SESAMs were used for comparison with the operation based upon the use of the GaSb SESAM; in this case, longer pulses with durations of 27 ps and 34 ps were obtained under the same experimental conditions. Our work sets a new record in pulse duration for mode-locked Tm:LuAG lasers and confirms that lattice-matched GaSb-based SESAMs are beneficial for mode-locked solid-state lasers in the 2 μm range...
February 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28198851/interrogation-of-metabolic-and-oxygen-states-of-tumors-with-fiber-based-luminescence-lifetime-spectroscopy
#8
Maria Lukina, Anna Orlova, Marina Shirmanova, Daniil Shirokov, Anton Pavlikov, Antje Neubauer, Hauke Studier, Wolfgang Becker, Elena Zagaynova, Toshitada Yoshihara, Seiji Tobita, Vladislav Shcheslavskiy
The study of metabolic and oxygen states of cells in a tumor in vivo is crucial for understanding of the mechanisms responsible for tumor development and provides background for the relevant tumor's treatment. Here, we show that a specially designed implantable fiber-optic probe provides a promising tool for optical interrogation of metabolic and oxygen states of a tumor in vivo. In our experiments, the excitation light from a ps diode laser source is delivered to the sample through an exchangeable tip via a multimode fiber, and the emission light is transferred to the detector by another multimode fiber...
February 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28198847/tuning-of-near-infrared-to-near-infrared-luminescence-from-one-photon-to-two-photon-anti-stokes-shift-in-ca-sub-3-sub-ga-sub-2-sub-sub-x-sub-cr-sub-x-sub-ge-sub-3-sub-o-sub-12-sub-via-varying-cr-sup-3-sup-content
#9
Huihong Lin, Ting Yu, Gongxun Bai, Qinyuan Zhang, Jianhua Hao
Near-infrared-to-near-infrared (NIR-to-NIR) anti-Stokes luminescence from Cr<sup>3+</sup> singly doped Ca<sub>3</sub>Ga<sub>2</sub>Ge<sub>3</sub>O<sub>12</sub> (CGGG) occurs under the excitation of an 808 nm diode laser. The anti-Stokes processes vary from one photon to two photon, depending on the Cr<sup>3+</sup> content (x) in Ca<sub>3</sub>Ga<sub>2-x</sub>Cr<sub>x</sub>Ge<sub>3</sub>O<sub>12</sub>...
February 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28198843/diode-end-pumped-ho-pr-liluf-sub-4-sub-bulk-laser-at-2-95%C3%A2-%C3%A2-%C3%AE-m
#10
Hongkun Nie, Peixiong Zhang, Baitao Zhang, Kejian Yang, Lianhan Zhang, Tao Li, Shuaiyi Zhang, Jianqiu Xu, Yin Hang, Jingliang He
A diode-end-pumped continuous-wave (CW) and passively Q-switched Ho, Pr:LiLuF<sub>4</sub> (Ho, Pr:LLF) laser operation at 2.95 μm was demonstrated for the first time, to the best of our knowledge. The maximum CW output power was 172 mW. By using a monolayer graphene as the saturable absorber, the passively Q-switched operation was realized, in which regimes with the highest output power, the shortest pulse duration, and the maximum repetition rate were determined to be 88 mW, 937.5 ns, and 55.7 kHz, respectively...
February 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28198835/methane-based-in-situ-temperature-rise-measurement-in-a-diode-pumped-rubidium-laser
#11
Rui Wang, Zining Yang, Hongyan Wang, Xiaojun Xu
We measured active zone temperature rise of an operational diode-pumped rubidium laser non-perturbatively with methane-based near-infrared tunable diode laser spectroscopy (TDLAS). For a Rb+ methane diode-pumped alkali laser (DPAL), the temperature rise was obtained. Especially, the temperature differences (∼10  K) between lasing and un-lasing cases were well identified, which demonstrated a high sensitivity of the method. To our knowledge, this is the first demonstration of extending the methane-based TDLAS method to DPAL study...
February 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28198804/investigating-carrier-localization-and-transfer-in-ingan-gan-quantum-wells-with-v-pits-using-near-field-scanning-optical-microscopy-and-correlation-analysis
#12
MinKwan Kim, Sunghan Choi, Joo-Hyung Lee, ChungHyun Park, Tae-Hoon Chung, Jong Hyeob Baek, Yong-Hoon Cho
The V-pits and potential fluctuations in InGaN/GaN multiple quantum wells (MQWs) are key factors for understanding the performance of InGaN/GaN-based light-emitting diodes (LEDs). However, photoluminescence (PL) measurements using conventional optical microscopy only provide ensemble information due to the spatial resolution limit, known as the diffraction barrier, which hinders the analysis of dislocations and potential fluctuations. Here, in order to investigate the influence of the V-pits and potential fluctuations on local optical properties, we performed nanoscopic luminescence mapping for standard and V-pit InGaN/GaN MQWs samples with different sized V-pits using near-field scanning optical microscopy (NSOM) with illumination mode (I-mode) at various laser excitation powers...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28192298/near-infrared-808-and-980%C3%A2-nm-excited-photoluminescence-study-in-nd-doped-y2o3-phosphor-for-bio-imaging
#13
Prasenjit Prasad Sukul, Kaushal Kumar
The upconversion (UC) process in lanthanide-doped nanophosphors has attracted great research interest for its extensive application potential in biological in vitro and in vivo imaging due to the high tissue penetration depth of near-infrared excitation and low autofluorescence background. In this article, the authors report the synthesis of oxide nanophosphor of size  ⩽50 nm, which forms stable aqueous dispersion. The photoluminescence study is made on the nanophosphor upon 808 and 980 nm diode laser excitations...
October 11, 2016: Methods and Applications in Fluorescence
https://www.readbyqxmd.com/read/28186464/evaluation-of-antimicrobial-photodynamic-therapy-using-indocyanine-green-and-near-infrared-diode-laser-against-enterococcus-faecalis-in-infected-human-root-canals
#14
Charis Beltes, Nikolaos Economides, Hercules Sakkas, Chrissanthy Papadopoulou, Theodoros Lambrianidis
OBJECTIVE: Photodynamic therapy (PDT) is considered a promising adjunct to the currently available endodontic disinfection techniques leading to more effective reduction of intracanal bacteria. The present ex vivo study aimed to assess the antimicrobial effect of PDT using indocyanine green (ICG) as photosensitizer and a near-infrared (NIR) diode laser in root canals of human teeth infected with Enterococcus faecalis. MATERIALS AND METHODS: Ninety single-rooted teeth after chemomechanical preparation and sterilization were contaminated with an E...
February 9, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28181571/high-power-dual-wavelength-ho-doped-fiber-laser-at-2%C3%A2-%C3%AE-m-tandem-pumped-by-a-1-15%C3%A2-%C3%AE-m-fiber-laser
#15
Xiaoxi Jin, Zhaokai Lou, Yizhu Chen, Pu Zhou, Hanwei Zhang, Hu Xiao, Zejin Liu
We demonstrated a high-power continuous-wave (CW) dual-wavelength Ho-doped fiber laser (HDFL) at 2049 nm and 2153 nm with a simple coupled-cavity configuration. A ~100 W laser diode-pumped fiber laser at 1150 nm served as the pump source. The maximum output power reached ~22.3 W and the slope efficiency was 23%. By altering the incident pump power, the power ratio of two signal wavelengths could be tuned in a large range due to gain competition. As far as we know, this is the first CW dual-wavelength HDFL with the power exceeding ten-watt-level, and the first dual-wavelength HDFL with the central wavelengths exceeding 2...
February 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28181222/systematic-review-of-laser-therapy-in-xanthelasma-palpebrarum
#16
REVIEW
Austin H Nguyen, Adam M Vaudreuil, Christopher J Huerter
Xanthelasma palpebrarum is a benign periorbital xanthoma with substantial cosmetic and psychosocial burden for patients. Treatment modalities should be considered based on efficacy as well as cosmetic outcome. Laser modalities in the treatment of xanthelasma palpebrarum have not been comprehensively reviewed and discussed. Accordingly, this study seeks to systematically and critically review the available literature discussing laser treatment of xanthelasma palpebrarum. PubMed was systematically reviewed for reports on laser therapy in the treatment of xanthelasma palpebrarum...
March 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28180132/study-of-material-properties-important-for-an-optical-property-modulation-based-radiation-detection-method-for-positron-emission-tomography
#17
Li Tao, Henry M Daghighian, Craig S Levin
We compare the performance of two detector materials, cadmium telluride (CdTe) and bismuth silicon oxide (BSO), for optical property modulation-based radiation detection method for positron emission tomography (PET), which is a potential new direction to dramatically improve the annihilation photon pair coincidence time resolution. We have shown that the induced current flow in the detector crystal resulting from ionizing radiation determines the strength of optical modulation signal. A larger resistivity is favorable for reducing the dark current (noise) in the detector crystal, and thus the higher resistivity BSO crystal has a lower (50% lower on average) noise level than CdTe...
January 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/28174272/pure-circular-polarization-electroluminescence-at-room-temperature-with-spin-polarized-light-emitting-diodes
#18
Nozomi Nishizawa, Kazuhiro Nishibayashi, Hiro Munekata
We report the room-temperature electroluminescence (EL) with nearly pure circular polarization (CP) from GaAs-based spin-polarized light-emitting diodes (spin-LEDs). External magnetic fields are not used during device operation. There are two small schemes in the tested spin-LEDs: first, the stripe-laser-like structure that helps intensify the EL light at the cleaved side walls below the spin injector Fe slab, and second, the crystalline AlOx spin-tunnel barrier that ensures electrically stable device operation...
February 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28169258/the-effect-of-indocyanine-green-mediated-photodynamic-therapy-as-an-adjunct-to-scaling-and-root-planing-in-the-treatment-of-chronic-periodontitis-a-comparative-split-mouth-randomized-clinical-trial
#19
Saurabh H Shingnapurkar, Dipika K Mitra, Mitali Suresh Kadav, Rohit A Shah, Silvia V Rodrigues, Saurabh S Prithyani
OBJECTIVE: The aim of this study was to assess the effect of adjunctive photodynamic therapy (PDT) (using 810 nm diode laser and Indocyanine green as photosensitizer) in chronic periodontitis. MATERIALS AND METHODS: Patients with untreated chronic periodontitis were included. Treatment was done according to a split mouth design. All sites received periodontal treatment comprising scaling and root-planing (SRP). Test group were additionally treated with PDT. Plaque Index (PI), Gingival Index (GI), Probing Pocket Depth (PPD) and Relative Attachment Level (RAL) were evaluated at baseline, 1 month and 3 months...
November 2016: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/28165053/turbulent-chimeras-in-large-semiconductor-laser-arrays
#20
J Shena, J Hizanidis, V Kovanis, G P Tsironis
Semiconductor laser arrays have been investigated experimentally and theoretically from the viewpoint of temporal and spatial coherence for the past forty years. In this work, we are focusing on a rather novel complex collective behavior, namely chimera states, where synchronized clusters of emitters coexist with unsynchronized ones. For the first time, we find such states exist in large diode arrays based on quantum well gain media with nearest-neighbor interactions. The crucial parameters are the evanescent coupling strength and the relative optical frequency detuning between the emitters of the array...
February 6, 2017: Scientific Reports
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