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https://www.readbyqxmd.com/read/29776006/mineralization-can-be-an-incidental-ultrasonographic-finding-in-equine-tendons-and-ligaments
#1
Etienne J O O'Brien, Roger K W Smith
Tendon/ligament mineralization is recognized in horses but information regarding its clinical significance is limited. The aims of this observational study were to report the structures most commonly affected by ultrasonographically detectable mineralization and, for these, determine frequency of diagnosis and key clinical features. Cases presented at our hospital in April 1999-April 2013 and September 2014-November 2015 were included: a total of 27 horses (22 retrospective, five prospective). Mineralizations were most common in deep digital flexor tendons (10) and suspensory ligament branches (eight), representing 10% and 7% (estimated), respectively, of horses diagnosed with injuries to these structures during the study...
May 18, 2018: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29774805/men-s-preconception-health-a-primary-health-care-viewpoint
#2
Anthony Paul O'Brien, John Hurley, Paul Linsley, Karen Anne McNeil, Richard Fletcher, John Robert Aitken
The purpose of this article is to theoretically explore men's preconception health as a mechanism to enhance fertility, as well as the health and well-being of the subject and his descendants. Premorbid risk factors and behaviors associated with stress, environmental toxins, excessive alcohol consumption, smoking, lack of exercise/obesity, and the use of illicit drugs are all known to affect fecundity. While there are many health clinics available to women, where advice in areas such as postnatal care of the newborn, family planning, and couples fertility is provided, there are few, if any, equivalent health clinics available to men...
May 1, 2018: American Journal of Men's Health
https://www.readbyqxmd.com/read/29773902/nedd9-promotes-oncogenic-signaling-a-stem-mesenchymal-gene-signature-and-aggressive-ovarian-cancer-growth-in-mice
#3
Rashid Gabbasov, Fang Xiao, Caitlin G Howe, Laura E Bickel, Shane W O'Brien, Daniel Benrubi, Thuy-Vy Do, Yan Zhou, Emmanuelle Nicolas, Kathy Q Cai, Samuel Litwin, Sachiko Seo, Erica A Golemis, Denise C Connolly
Neural precursor cell expressed, developmentally downregulated 9 (NEDD9) supports oncogenic signaling in a number of solid and hematologic tumors. Little is known about the role of NEDD9 in ovarian carcinoma (OC), but available data suggest elevated mRNA and protein expression in advanced stage high-grade cancers. We used a transgenic MISIIR-TAg mouse OC model combined with genetic ablation of Nedd9 to investigate its action in the development and progression of OC. A Nedd9-/- genotype delayed tumor growth rate, reduced incidence of ascites, and reduced expression and activation of signaling proteins including SRC, STAT3, E-cadherin, and AURKA...
May 18, 2018: Oncogene
https://www.readbyqxmd.com/read/29773206/concurrent-insomnia-and-habitual-snoring-are-associated-with-adverse-pregnancy-outcomes
#4
Michele L Okun, Louise M O'Brien
OBJECTIVES: Pregnant women report disturbed sleep, including habitual snoring and insomnia. The co-occurrence among non-pregnant cohorts is 30%-50% with increased risk for adverse health outcomes. To date, no study has examined the comorbid status or impact in pregnant women. METHODS: The prevalence of insomnia (INS) and habitual snoring (HS) were examined in 439 women in the third trimester (34.1 ± 3.7 weeks). Habitual snoring (snoring ≥3 times/week) was self-reported...
June 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29771948/a-consistent-and-general-modified-venn-diagram-approach-that-provides-insights-into-regression-analysis
#5
Robert M O'Brien
Venn diagrams are used to provide an intuitive understanding of multiple regression analysis and these diagrams work well with two variables. The area of overlap of the two variables has a one-to-one relationship to the squared correlation between them. This approach breaks down, however, with three-variables. Making the overlap between the pairs of variables consistent with their squared bivariate correlations often results in the overlap of two of these variables with the third variable that is not the same as the variance of the third variable accounted for by the other two variables...
2018: PloS One
https://www.readbyqxmd.com/read/29771938/ability-of-%C3%AE-%C3%AE-t-cells-to-modulate-the-foxp3-t-cell-response-is-dependent-on-adenosine
#6
Dongchun Liang, Jeong-Im Woo, Hui Shao, Willi K Born, Rebecca L O'Brien, Henry J Kaplan, Deming Sun
Whether γδ T cells inhibit or enhance the Foxp3 T cell response depends upon their activation status. The critical enhancing effector in the supernatant is adenosine. Activated γδ T cells express adenosine receptors at high levels, which enables them to deprive Foxp3+ T cells of adenosine, and to inhibit their expansion. Meanwhile, cell-free supernatants of γδ T cell cultures enhance Foxp3 T cell expansion. Thus, inhibition and enhancement by γδ T cells of Foxp3 T cell response are a reflection of the balance between adenosine production and absorption by γδ T cells...
2018: PloS One
https://www.readbyqxmd.com/read/29771338/cost-effectiveness-analysis-of-an-adherence-promotion-intervention-for-children-with-leukemia-a-markov-model-based-simulation
#7
Meghan E McGrady, Mark H Eckman, Maureen M O'Brien, Ahna L H Pai
Objective: Improving medication adherence among children with B-cell precursor acute lymphoblastic leukemia (B-ALL) has the potential to reduce relapse rates but requires an investment in resources. An economic evaluation is needed to understand the potential costs and benefits of delivering adherence-promotion interventions (APIs) as part of standard clinical care. Methods: A Markov decision analytic model was used to simulate the potential incremental cost-effectiveness per quality-adjusted life year (QALY) to be gained from an API for children with B-ALL in first continuous remission compared with treatment as usual (TAU, no intervention)...
May 15, 2018: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29770960/interventions-for-increasing-fruit-and-vegetable-consumption-in-children-aged-five-years-and-under
#8
REVIEW
Rebecca K Hodder, Kate M O'Brien, Fiona G Stacey, Rebecca J Wyse, Tara Clinton-McHarg, Flora Tzelepis, Erica L James, Kate M Bartlem, Nicole K Nathan, Rachel Sutherland, Emma Robson, Sze Lin Yoong, Luke Wolfenden
BACKGROUND: Insufficient consumption of fruits and vegetables in childhood increases the risk of future non-communicable diseases, including cardiovascular disease. Interventions to increase consumption of fruit and vegetables, such as those focused on specific child-feeding strategies and parent nutrition education interventions in early childhood may therefore be an effective strategy in reducing this disease burden. OBJECTIVES: To assess the effectiveness, cost effectiveness and associated adverse events of interventions designed to increase the consumption of fruit, vegetables or both amongst children aged five years and under...
May 17, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29770185/does-colour-filling-in-account-for-colour-perception-in-natural-images
#9
Christopher W Tyler, Joshua A Solomon
It is popular to attribute the appearance of extended colour fields to a process of filling-in from the differential colour signals at colour edges, where one colour transitions to another. We ask whether such a process can account for the appearance of extended colour fields in natural images. Some form of colour filling-in must underlie the equiluminant colour Craik-O'Brien-Cornsweet effect and the Watercolour Effect, but these effects are too weak to account for the appearance of extended colour fields in natural images...
May 2018: I-Perception
https://www.readbyqxmd.com/read/29769624/serial-minimal-residual-disease-mrd-monitoring-during-first-line-fcr-treatment-for-cll-may-direct-individualized-therapeutic-strategies
#10
Philip A Thompson, Christine B Peterson, Paolo Strati, Jeff Jorgensen, Michael J Keating, Susan M O'Brien, Alessandra Ferrajoli, Jan A Burger, Zeev Estrov, Nitin Jain, Tapan M Kadia, Gautam Borthakur, Courtney D DiNardo, Naval Daver, Elias Jabbour, William G Wierda
Achieving undetectable MRD (U-MRD) status after chemoimmunotherapy predicts longer progression-free and overall survival. The predictive factors and timing of relapse in patients with U-MRD and value of interim MRD analysis are ill-defined. This was a prospective study of 289 patients with CLL treated first-line with FCR. MRD analysis was performed after course 3 (C3) and at end of therapy (EOT) in bone marrow using 4-color flow cytometry (sensitivity 10-4 ). Eighteen percent of patients had U-MRD after C3 and 48% at EOT...
April 17, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29768164/epigenomic-guided-mass-cytometry-profiling-reveals-disease-specific-features-of-exhausted-cd8-t-cells
#11
Bertram Bengsch, Takuya Ohtani, Omar Khan, Manu Setty, Sasikanth Manne, Shaun O'Brien, Pier Federico Gherardini, Ramin Sedaghat Herati, Alexander C Huang, Kyong-Mi Chang, Evan W Newell, Niels Bovenschen, Dana Pe'er, Steven M Albelda, E John Wherry
Exhausted CD8 T (Tex) cells are immunotherapy targets in chronic infection and cancer, but a comprehensive assessment of Tex cell diversity in human disease is lacking. Here, we developed a transcriptomic- and epigenetic-guided mass cytometry approach to define core exhaustion-specific genes and disease-induced changes in Tex cells in HIV and human cancer. Single-cell proteomic profiling identified 9 distinct Tex cell clusters using phenotypic, functional, transcription factor, and inhibitory receptor co-expression patterns...
May 15, 2018: Immunity
https://www.readbyqxmd.com/read/29765748/crystal-structure-of-2-8-aminona-phthalen-1-yl-imino-meth-yl-4-6-di-tert-butyl-phenolato-%C3%AE%C2%BA-3-n-n-o-bromido-nickel-ii
#12
Patrick O'Brien, Matthias Zeller, Wei-Tsung Lee
The title compound, [NiBr(C25 H29 N2 O)], contains an NiII atom with a slightly distorted square-planar coordination environment defined by one O and two N atoms from the 2-{[(8-aminona-phthalen-1-yl)imino]-meth-yl}-4,6-di- tert -butyl-phenolate ligand and a bromide anion. The Ni-O and Ni-N bond lengths are slightly longer than those observed in the phenyl backbone counterpart, which can be attributed to the larger steric hindrance of the naphthyl group in the structure of the title compound. The mol-ecule as a whole is substanti-ally distorted, with both the planar naphthalene-1,8-di-amine and imino-meth-yl-phenolate substitutents rotated against the NiN2 OBr plane by 38...
April 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/29765200/efficacy-and-safety-of-the-crth2-antagonist-azd1981-as-add-on-therapy-to-inhaled-corticosteroids-and-long-acting-%C3%AE-2-agonists-in-patients-with-atopic-asthma
#13
Eric D Bateman, Christopher O'Brien, Paul Rugman, Sally Luke, Stefan Ivanov, Mohib Uddin
Objectives: To evaluate the efficacy and safety of AZD1981, a potent, specific antagonist of the CRTh2 receptor, as add-on therapy to inhaled corticosteroids (ICS) and long-acting β2 -agonists (LABA), in patients with persistent asthma with an allergic component. Patients and methods: In this placebo-controlled, parallel-group Phase IIb study, patients with persistent atopic asthma on ICS and LABA were randomized to receive 12 weeks of treatment with placebo or AZD1981 (80 mg daily, 200 mg daily, and 10 mg, 40 mg, 100 mg, or 400 mg twice daily [BID])...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29764173/developing-palliative-care-programs-in-indigenous-communities-using-participatory-action-research-a-canadian-application-of-the-public-health-approach-to-palliative-care
#14
Mary Lou Kelley, Holly Prince, Shevaun Nadin, Kevin Brazil, Maxine Crow, Gaye Hanson, Luanne Maki, Lori Monture, Christopher J Mushquash, Valerie O'Brien, Jeroline Smith
BACKGROUND: The Indigenous people of Canada include First Nations, Inuit and Metis. This research focused on four diverse First Nations communities located in Ontario and Manitoba. First Nations communities have well-established culturally-based social processes for supporting their community members experiencing dying, loss, grief and bereavement. However, communities do not have formalized local palliative care (PC) programs and have limited access to medical services, especially pain and symptom management...
April 2018: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/29762075/predicting-length-of-hospice-stay-an-application-of-quantile-regression
#15
Brystana G Kaufman, David Klemish, Cordt T Kassner, Jerome P Reiter, Fan Li, Matthew Harker, Emily C O'Brien, Donald H Taylor, Nrupen A Bhavsar
BACKGROUND: Use of the Medicare hospice benefit has been associated with high-quality care at the end of life, and hospice length of use in particular has been used as a proxy for appropriate timing of hospice enrollment. Quantile regression has been underutilized as an alternative tool to model distributional changes in hospice length of use and hospice payments outside of the mean. OBJECTIVE: To test for heterogeneity in the relationship between patient characteristics and hospice outcomes across the distribution of hospice days...
May 15, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29761754/pathways-to-recovery-development-and-evaluation-of-a-cognitive-behavioural-therapy-in-patient-treatment-programme-for-adults-with-anorexia-nervosa
#16
Andrea Brown, Richard Jenkinson, Julia Coakes, Annette Cockfield, Tish O'Brien, Louise Hall
Aims and methodA cognitive-behavioural therapy in-patient treatment model for adults with severe anorexia nervosa was developed and evaluated, and outcomes were compared with the previous treatment model and other published outcomes from similar settings. RESULTS: This study showed the Pathways to Recovery outcomes were positive in terms of improvements in body mass index and psychopathology.Clinical implicationsAdults with anorexia nervosa can achieve good outcomes despite longer illness duration and comorbidities...
June 2018: BJPsych Bulletin
https://www.readbyqxmd.com/read/29759943/randomized-controlled-trial-of-home-based-4-week-tdcs-in-chronic-minimally-conscious-state
#17
Géraldine Martens, Nicolas Lejeune, Anthony Terrence O'Brien, Felipe Fregni, Charlotte Martial, Sarah Wannez, Steven Laureys, Aurore Thibaut
BACKGROUND: Patients with chronic disorders of consciousness face a significant lack of treatment options. OBJECTIVE: We aimed at investigating the feasibility and the behavioral effects of home-based transcranial direct current stimulation (tDCS), applied by relatives or caregivers, in chronic patients in minimally conscious state (MCS). METHODS: Each participant received, in a randomized order, 20 sessions of active and 20 sessions of sham tDCS applied over the prefrontal cortex for 4 weeks; separated by 8 weeks of washout...
May 2, 2018: Brain Stimulation
https://www.readbyqxmd.com/read/29755172/retrospective-review-of-student-research-projects-in-a-canadian-master-of-science-in-physical-therapy-programme-and-the-perceived-impact-on-advisors-research-capacity-education-clinical-practice-knowledge-translation-and-health-policy
#18
Courtney Lacey, Stephanie Scodras, Julie Ardron, Ryan Sellan, Martyna Garbaczewska, Kelly K O'Brien, Nancy M Salbach
Purpose: This study's aim was to characterize the nature of students' research conducted for a Master of Science in Physical Therapy (MScPT) degree programme at a Canadian university and evaluate the lead advisors' perspectives of its impact on their research capacity, education, clinical practice, knowledge translation, and health policy. Methods: We conducted a quantitative, cross-sectional, retrospective review of research reports from 2003 to 2014 to characterize the MScPT students' research and a quantitative, cross-sectional e-survey of lead research advisors to evaluate the impact of this research...
2018: Physiotherapy Canada. Physiothérapie Canada
https://www.readbyqxmd.com/read/29753703/ngr-htnf-in-combination-with-best-investigator-choice-in-previously-treated-malignant-pleural-mesothelioma-ngr015-a-randomised-double-blind-placebo-controlled-phase-3-trial
#19
Vanesa Gregorc, Rabab M Gaafar, Adolfo Favaretto, Francesco Grossi, Jacek Jassem, Andreas Polychronis, Paolo Bidoli, Marcello Tiseo, Riyaz Shah, Paul Taylor, Silvia Novello, Alberto Muzio, Alessandra Bearz, Laurent Greillier, Floriana Fontana, Giulia Salini, Antonio Lambiase, Mary O'Brien
BACKGROUND: Malignant pleural mesothelioma is an aggressive cancer with highly vascularised tumours. It has poor prognosis and few treatment options after failure of first-line chemotherapy. NGR-hTNF is a vascular-targeting drug that increases penetration of intratumoral chemotherapy and T-cell infiltration by modifying the tumour microenvironment. In this trial, we aimed to investigate the efficacy and safety of NGR-hTNF in patients with malignant pleural mesothelioma who had progressed during or after a first-line treatment...
May 9, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29753490/technical-note-evaluation-of-a-sonographic-overbagging-edema-scoring-system-for-show-cows-comparison-with-visual-inspection
#20
M Balmer, M Alsaaod, M Boesiger, R O'Brien, A Steiner
Overbagged udders are commonly seen at dairy cow shows due to prolonged milking intervals. The aims of this study were to describe the prevalence of udder edema in dairy cows at shows as determined by sonography and to suggest a sonographic scoring system, which was evaluated for reproducibility and repeatability. At 4 highly competitive Swiss dairy cow shows, 319 cows of various breeds were examined. Sonographic scans-1 from each fore quarter and 1 from the rear, representing both hind quarters-were collected by 3 experienced veterinarians at defined positions predisposed to overbagging edema...
May 9, 2018: Journal of Dairy Science
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