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https://www.readbyqxmd.com/read/28433790/a-strain-mediated-corrosion-model-for-bioabsorbable-metallic-stents
#1
E Galvin, D O'Brien, C Cummins, B J Mac Donald, C Lally
This paper presents a strain-mediated phenomenological corrosion model, based on the discrete finite element modelling method which was developed for use with the ANSYS Implicit finite element code. The corrosion model was calibrated from experimental data and used to simulate the corrosion performance of a WE43 magnesium alloy stent. The model was found to be capable of predicting the experimentally observed plastic strain-mediated mass loss profile. The non-linear plastic strain model, extrapolated from the experimental data, was also found to adequately capture the corrosion-induced reduction in the radial stiffness of the stent over time...
April 19, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28433121/a-new-complication-associated-with-the-use-of-prophylactic-intracameral-antibiotics-hemorrhagic-occlusive-retinal-vasculitis
#2
EDITORIAL
Stephen G Schwartz, Nidhi Relhan, Terrence P O'Brien, Harry W Flynn
No abstract text is available yet for this article.
May 2017: Ophthalmology
https://www.readbyqxmd.com/read/28432883/sagittal-plane-joint-kinetics-during-stair-ascent-in-patients-with-peripheral-arterial-disease-and-intermittent-claudication
#3
Stephanie L King, Natalie Vanicek, Thomas D O'Brien
Stair negotiation poses a substantial physical demand on the musculoskeletal system and this challenging task can place individuals at risk of falls. Peripheral arterial disease (PAD) can cause intermittent claudication (IC) pain in the calf and results in altered gait mechanics during level walking. However, whether those with PAD-IC adopt alternate strategies to climb stairs is unknown. Twelve participants with PAD-IC (six bilateral and six unilateral) and 10 healthy controls were recruited and instructed to ascend a five-step staircase whilst 3D kinematic data of the lower-limbs were recorded synchronously with kinetic data from force plates embedded into the staircase on steps two and three...
March 28, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28432792/monte-carlo-study-of-the-chamber-phantom-air-gap-effect-in-a-magnetic-field
#4
Daniel J O'Brien, Gabriel O Sawakuchi
PURPOSE: The aim of this study was to examine the effect of sub-millimeter air gaps that may exist between an ionization chamber and solid phantoms when measurements are performed in a magnetic field. METHODS: Geant4 Monte Carlo simulations were performed using a model of a PTW 30013 Farmer chamber in a water phantom. Symmetrical and asymmetrical air gaps of various thicknesses were modeled surrounding the chamber, and the dose to the air cavity of the chamber was scored in each case...
April 22, 2017: Medical Physics
https://www.readbyqxmd.com/read/28431432/contrast-sensitivity-and-lateral-inhibition-are-enhanced-with-macular-carotenoid-supplementation
#5
James M Stringham, Kevin J O'Brien, Nicole T Stringham
Purpose: Once deposited in the retina, the so-called macular carotenoids lutein (L), zeaxanthin (Z), and mesozeaxanthin (MZ) have been shown to enhance visual performance. The purpose of our study was to investigate whether increasing macular pigment optical density (MPOD) could enhance lateral inhibitory processes, and thereby improve contrast sensitivity (CS). Methods: A total of 59 young (18-25 years), healthy individuals participated in this 1-year, double-masked, placebo-controlled study...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28431288/longitudinal-whole-brain-atrophy-and-ventricular-enlargement-in-nondemented-parkinson-s-disease
#6
Elijah Mak, Li Su, Guy B Williams, Michael J Firbank, Rachael A Lawson, Alison J Yarnall, Gordon W Duncan, Brit Mollenhauer, Adrian M Owen, Tien K Khoo, David J Brooks, James B Rowe, Roger A Barker, David J Burn, John T O'Brien
We investigated whole-brain atrophy and ventricular enlargement over 18 months in nondemented Parkinson's disease (PD) and examined their associations with clinical measures and baseline CSF markers. PD subjects (n = 100) were classified at baseline into those with mild cognitive impairment (MCI; PD-MCI, n = 36) and no cognitive impairment (PD-NC, n = 64). Percentage of whole-brain volume change (PBVC) and ventricular expansion over 18 months were assessed with FSL-SIENA and ventricular enlargement (VIENA) respectively...
March 16, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28429879/the-pursuit-of-accurate-blood-pressure-measurement-a-35-year-travail
#7
EDITORIAL
Eoin O'Brien, George S Stergiou
No abstract text is available yet for this article.
April 21, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28429711/single-photon-test-of-hyper-complex-quantum-theories-using-a-metamaterial
#8
Lorenzo M Procopio, Lee A Rozema, Zi Jing Wong, Deny R Hamel, Kevin O'Brien, Xiang Zhang, Borivoje Dakić, Philip Walther
In standard quantum mechanics, complex numbers are used to describe the wavefunction. Although this has so far proven sufficient to predict experimental results, there is no theoretical reason to choose them over real numbers or generalizations of complex numbers, that is, hyper-complex numbers. Experiments performed to date have proven that real numbers are insufficient, but the need for hyper-complex numbers remains an open question. Here we experimentally probe hyper-complex quantum theories, studying one of their deviations from complex quantum theory: the non-commutativity of phases...
April 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28428911/early-rehabilitation-of-distal-radius-fractures-stabilized-by-volar-locking-plate-a-prospective-randomized-pilot-study
#9
Stefan Quadlbauer, Christoph Pezzei, Josef Jurkowitsch, Brigitta Kolmayr, Tina Keuchel, Daniel Simon, Thomas Hausner, Martin Leixnering
Background Distal radius fractures are very common and an increased incidence of 50% is estimated by 2030. Therefore, both operative and postsurgical treatment remains pertinent. Main aim in treating intra-articular fractures is to restore the articular surface by internal fixation and early mobilization (EM). Questions/Purposes The purpose of this study was to compare functional results between EM immediately after surgery and 5 weeks of immobilization (IM). Patients and Methods In a randomized prospective study, 30 patients with an isolated distal radius fracture were treated by open reduction and internal fixation using a single volar locking plate excluding bone graft...
May 2017: Journal of Wrist Surgery
https://www.readbyqxmd.com/read/28427892/contour-adaptation-reduces-the-spreading-of-edge-induced-colors
#10
Andrew J Coia, Michael A Crognale
Brief exposure to flickering achromatic outlines of an area causes a reduction in the brightness contrast of the surface inside the area. This contour adaptation to achromatic contours does not reduce surface contrast when the surface is chromatic (the saturation or colorimetric purity of the surface is maintained). In addition to reducing the brightness of physical luminance contrast, contour adaptation also reduces (or even reverses) the illusory brightness contrast seen in the Craik-O'Brien-Cornsweet illusion, in which two physically identical grey areas appear different brightness because of a sharp luminance edge separating them...
April 17, 2017: Vision Research
https://www.readbyqxmd.com/read/28426856/adjunctive-oral-voriconazole-treatment-of-fusarium-keratitis-a-secondary-analysis-from-the-mycotic-ulcer-treatment-trial-ii
#11
N Venkatesh Prajna, Tiruvengada Krishnan, Revathi Rajaraman, Sushila Patel, Ranjeet Shah, Muthiah Srinivasan, Lumbini Devi, Manoranjan Das, Kathryn J Ray, Kieran S O'Brien, Catherine E Oldenburg, Stephen D McLeod, Michael E Zegans, Nisha R Acharya, Thomas M Lietman, Jennifer Rose-Nussbaumer
Importance: Fusarium keratitis is common and often results in poor outcomes. No new treatments since natamycin have become available. Objective: To explore the role of adjuvant oral voriconazole on clinical outcomes in Fusarium keratitis. Design, Setting, and Participants: In this prespecified subgroup analysis of a multicenter, double-masked, placebo-controlled randomized clinical trial, 240 patients from the Aravind Eye Care System in India, the Lumbini Eye Hospital and Bharatpur Eye Hospital in Nepal, and the University of California, San Francisco, who had culture-positive fungal ulcer and baseline visual acuity of 20/400 or worse were randomized to receive oral voriconazole vs placebo...
April 20, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28425334/remifentanil-for-sedation-of-children-with-traumatic-brain-injury
#12
James L Hungerford, Nicole O'Brien, Melissa Moore-Clingenpeel, Eric A Sribnick, Cheryl Sargel, Mark Hall, Jeffrey R Leonard, Joseph D Tobias
OBJECTIVE: To determine whether remifentanil would provide adequate sedation while allowing frequent and reproducible neurologic assessments in children admitted to the pediatric intensive care unit (PICU) with traumatic brain injury (TBI) during mechanical ventilation. DESIGN: Retrospective review. SETTING: Tertiary care PICU. PATIENTS: Thirty-eight patients over a 30-month period. MEASUREMENTS AND MAIN RESULTS: Median age was 9 years (interquartile range [IQR] 2...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/28425185/the-influence-of-hippocampal-atrophy-on-the-cognitive-phenotype-of-dementia-with-lewy-bodies
#13
Greg J Elder, Karen Mactier, Sean J Colloby, Rosie Watson, Andrew M Blamire, John T O'Brien, John-Paul Taylor
OBJECTIVE: The level of hippocampal atrophy in dementia with Lewy bodies (DLB) is typically less than that observed in Alzheimer's disease (AD). However, it is not known how the cognitive phenotype of DLB is influenced by hippocampal atrophy or the atrophy of adjacent medial temporal lobe structures. METHODS: Dementia with Lewy bodies (n = 65), AD (n = 76) and control (n = 63) participants underwent 3T magnetic resonance imaging and cognitive Cambridge Cognitive Examination and Mini-Mental State Examination (CAMCOG and MMSE) assessments...
April 20, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28424234/braf-v600-mutation-detection-in-melanoma-a-comparison-of-two-laboratory-testing-methods
#14
Odharnaith O'Brien, Tomas Lyons, Sandra Murphy, Linda Feeley, Derek Power, Cynthia C B B Heffron
AIMS: The assessment of B-raf proto-oncogene, serine/threonine kinase (BRAF) gene status is now standard practice in patients diagnosed with metastatic melanoma with its presence predicting a clinical response to treatment with BRAF inhibitors. The gold standard in determining BRAF status is currently by DNA-based methods. More recently, a BRAF V600E antibody has been developed. We aim to investigate whether immunohistochemical detection of BRAF mutation is a suitable alternative to molecular testing by polymerase chain reaction (PCR)...
April 19, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28421364/an-ovine-in-vivo-framework-for-tracheobronchial-stent-analysis
#15
Donnacha J McGrath, Anja Lena Thiebes, Christian G Cornelissen, Mary B O'Shea, Barry O'Brien, Stefan Jockenhoevel, Mark Bruzzi, Peter E McHugh
Tracheobronchial stents are most commonly used to restore patency to airways stenosed by tumour growth. Currently all tracheobronchial stents are associated with complications such as stent migration, granulation tissue formation, mucous plugging and stent strut fracture. The present work develops a computational framework to evaluate tracheobronchial stent designs in vivo. Pressurised computed tomography is used to create a biomechanical lung model which takes into account the in vivo stress state, global lung deformation and local loading from pressure variation...
April 19, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28419856/adenoma-prevalence-in-blacks-and-whites-having-equal-adherence-to-screening-colonoscopy-the-national-colonoscopy-study
#16
Robin B Mendelsohn, Sidney Winawer, Anjani Jammula, Glenn Mills, Paul Jordan, Michael J O'Brien, Georgia M Close, Michael Dorfman, Timothy R Church, Margaret T Mandelson, John Allen, Andrew Feld, Noah D Kauff, Georgia A Morgan, Julie M R Kumar, Victoria Serrano, Sharon Bayuga-Miller, Sara E Fischer, Deborah Kuk, Ann G Zauber
No abstract text is available yet for this article.
April 15, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28419849/rifm-fragrance-ingredient-safety-assessment-isoamyl-formate-cas-registry-number-110-45-2
#17
A M Api, D Belsito, D Botelho, D Browne, M Bruze, G A Burton, J Buschmann, P Calow, M L Dagli, M Date, W Dekant, C Deodhar, A D Fryer, K Joshi, S La Cava, A Lapczynski, D C Liebler, D O'brien, R Parakhia, A Patel, T M Penning, G Ritacco, J Romine, D Salvito, T W Schultz, I G Sipes, Y Thakkar, S Tsang, J Wahler
No abstract text is available yet for this article.
April 15, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28418817/virtual-mapping-of-the-frontal-recess-guiding-safe-and-efficient-frontal-sinus-surgery
#18
Neil S Patel, Amy C Dearking, Erin K O'Brien, John F Pallanch
Objective To define relationships between the frontal sinus opening, ostia of other frontal recess cells, and endoscopic landmarks and to develop a clinically useful framework to guide frontal sinus surgery. Study Design Retrospective review. Setting Tertiary care academic referral center. Methods Adult patients with computed tomography (CT) without sinonasal pathology were included. Virtual endoscopy (using OsiriX) and corresponding CT reconstructions were used to identify all visible ostia in the frontal recess and characterize their positions in spaces between the uncinate/agger nasi (U), bulla ethmoidalis (EB), and middle turbinate (MT)...
April 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28418303/azithromycin-resistance-and-decreased-ceftriaxone-susceptibility-in-neisseria-gonorrhoeae-hawaii-usa
#19
John R Papp, A Jeanine Abrams, Evelyn Nash, Alan R Katz, Robert D Kirkcaldy, Norman P O'Connor, Pamela S O'Brien, Derek H Harauchi, Eloisa V Maningas, Olusegun O Soge, Ellen N Kersh, Alan Komeya, Juval E Tomas, Glenn M Wasserman, Gail Y Kunimoto, David L Trees, A Christian Whelen
During 2016, eight Neisseria gonorrhoeae isolates from 7 patients in Hawaii were resistant to azithromycin; 5 had decreased in vitro susceptibility to ceftriaxone. Genomic analysis demonstrated a distinct phylogenetic clade when compared with local contemporary strains. Continued evolution and widespread transmission of these strains might challenge the effectiveness of current therapeutic options.
May 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28418294/exposure-risk-for-infection-and-lack-of-human-to-human-transmission-of-mycobacterium-ulcerans-disease-australia
#20
Daniel P O'Brien, James W Wynne, Andrew H Buultjens, Wojtek P Michalski, Timothy P Stinear, N Deborah Friedman, Andrew Hughes, Eugene Athan
We conducted epidemiologic and genetic analyses of family clusters of Mycobacterium ulcerans (Buruli ulcer) disease in southeastern Australia. We found that the incidence of M. ulcerans disease in family members was increased. However, the risk for exposure appeared short-term and not related to human-human transmission.
May 2017: Emerging Infectious Diseases
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