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https://www.readbyqxmd.com/read/29342249/splice-expression-variation-analysis-seva-for-inter-tumor-heterogeneity-of-gene-isoform-usage-in-cancer
#1
Bahman Afsari, Theresa Guo, Michael Considine, Liliana Florea, Luciane T Kagohara, Genevieve L Stein-O'Brien, Dylan Kelley, Emily Flam, Kristina D Zambo, Patrick K Ha, Donald Geman, Michael F Ochs, Joseph A Califano, Daria A Gaykalova, Alexander V Favorov, Elana J Fertig
Motivation: Current bioinformatics methods to detect changes in gene isoform usage in distinct phenotypes compare the relative expected isoform usage in phenotypes. These statistics model differences in isoform usage in normal tissues, which have stable regulation of gene splicing. Pathological conditions, such as cancer, can have broken regulation of splicing that increases the heterogeneity of the expression of splice variants. Inferring events with such differential heterogeneity in gene isoform usage requires new statistical approaches...
January 12, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29341444/teaching-clinical-leadership-to-medical-students
#2
Aileen O'Brien, Lucinda Etheridge, Judith Ibison, Anne-Marie Reid
No abstract text is available yet for this article.
January 16, 2018: Clinical Teacher
https://www.readbyqxmd.com/read/29340307/a-patient-with-ckd-develops-cholestatic-liver-injury-during-a%C3%A2-clinical-trial
#3
Emma D A Wagener, Nao Souma, Alexander Hodakowski, Carlos Martinez, Patrick Fox, Rupal Mehta, Matthew J O'Brien, Maureen Bolon, Laura Kulik, Guang-Yu Yang, Tamara Isakova
No abstract text is available yet for this article.
January 2018: KI Reports
https://www.readbyqxmd.com/read/29339314/surface-based-characteristics-of-the-cerebellar-cortex-visualized-with-ultra-high-field-mri
#4
Yohan Boillat, Pierre-Louis Bazin, Kieran O'Brien, Mário João Fartaria, Guillaume Bonnier, Gunnar Krueger, Wietske Van der Zwaag, Cristina Granziera
Although having a relatively homogeneous cytoarchitectonic organization, the cerebellar cortex is a heterogeneous region characterized by different amounts of myelin, iron and protein expression profiles. In this study, we used quantitative T1 and T2* mapping at ultra-high field (7T) MRI to investigate the tissue characteristics of the cerebellar gray matter surface and its layers. Detailed subject-specific surfaces were generated at three different cortical depths and averaged across subjects to create averaged T1 and T2* maps on the cerebellar surface...
January 12, 2018: NeuroImage
https://www.readbyqxmd.com/read/29338922/alcohol-consumption-masculinity-and-alcohol-related-violence-and-anti-social-behaviour-in-sportspeople
#5
Kerry S O'Brien, Walter Forrest, Iain Greenlees, Daniel Rhind, Sophia Jowett, Ilana Pinsky, Albert Espelt, Marina Bosque-Prous, Anders Larrabee Sonderlund, Matteo Vergani, Muhammad Iqbal
OBJECTIVES: There is no research examining alcohol-related aggression and anti-social behaviour in UK or European sportspeople (athletes), and no research has examined relationships between masculinity, alcohol consumption, and alcohol-related aggression and antisocial behaviour in sportspeople (athletes). This study addresses this gap. DESIGN: Cross-sectional. METHODS: A sample (N=2048; women=892, 44%) of in season sportspeople enrolled at UK universities (response 83%), completed measures of masculinity, alcohol consumption, within-sport (on-field) violence, and having been the perpetrator and/or victim of alcohol-related violent/aggressive and antisocial behaviour (e...
July 4, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29338459/an-interprofessional-collaborative-practice-approach-to-transform-heart-failure-care-an-overview
#6
Brenda K Zierler, Erin Abu-Rish Blakeney, Kevin D O'Brien, Ipcp Heart Failure Teams
Interprofessional collaborative practice (IPCP) approaches to health care are increasingly recognized as necessary to achieve the Triple Aim-improved health of the population, improved patient care experience, and improved affordability of care. This paper introduces and provides an overview of an interprofessional intervention to improve a healthcare team, healthcare system, and patient outcomes for hospitalized patients with heart failure. In this paper, we describe the overall project resulting from a workforce training grant and the proposed series of future papers resulting from the interprofessional intervention...
January 17, 2018: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/29338100/fixing-the-conformation-of-calix-4arenes-when-are-three-carbons-not-enough
#7
Susan Matthews, Samy Cecioni, John E O'Brien, Colin J MacDonald, David L Hughes, Garth A Jones, Stephen H Ashworth, Sébastien Vidal
Calix[4]arenes are unique macrocycles that through judicious functionalisation at the lower-rim can be either fixed in one of four conformations or remain conformationally flexible. Introduction of propynyl or propenyl groups unexpectedly provides a new possibility; a unidirectional conformational switch, with the 1,3-alternate and 1,2-alternate conformers switching to the partial cone conformation, whilst the cone conformation is unchanged, under standard experimental conditions. Using 1H NMR kinetic studies, rates of switching have been shown to be dependent on the starting conformation, upper-rim substituent, where reduction in bulk enables faster switching, solvent and temperature with 1,2-alternate conformations switching fastest...
January 16, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29337218/calcium-dependent-disorder-to-order-transitions-are-central-to-the-secretion-and-folding-of-the-cyaa-toxin-of-bordetella-pertussis-the-causative-agent-of-whooping-cough
#8
Darragh P O'Brien, Ana Cristina Sotomayor Perez, Johanna Karst, Sara E Cannella, Véronique Yvette Ntsogo Enguéné, Audrey Hessel, Dorothée Raoux-Barbot, Alexis Voegele, Orso Subrini, Marilyne Davi, J Inaki Guijarro, Bertrand Raynal, Bruno Baron, Patrick England, Belen Hernandez, Mahmoud Ghomi, Véronique Hourdel, Christian Malosse, Julia Chamot-Rooke, Patrice Vachette, Dominique Durand, Sébastien Brier, Daniel Ladant, Alexandre Chenal
The adenylate cyclase toxin (CyaA) plays an essential role in the early stages of respiratory tract colonization by Bordetella pertussis, the causative agent of whooping cough. Once secreted, CyaA invades eukaryotic cells, leading to cell death. The cell intoxication process involves a unique mechanism of translocation of the CyaA catalytic domain directly across the plasma membrane of the target cell. Herein, we review our recent results describing how calcium is involved in several steps of this intoxication process...
January 11, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29335618/long-term-maintenance-of-human-pluripotent-stem-cells-on-crgdfk-presenting-synthetic-surfaces
#9
Jack W Lambshead, Laurence Meagher, Jacob Goodwin, Tanya Labonne, Elizabeth Ng, Andrew Elefanty, Edouard Stanley, Carmel M O'Brien, Andrew L Laslett
Synthetic human pluripotent stem cell (hPSC) culture surfaces with defined physical and chemical properties will facilitate improved research and therapeutic applications of hPSCs. In this study, synthetic surfaces for hPSC culture in E8 medium were produced for screening by modifying two polymer brush coatings [poly(acrylamide-co-acrylic acid) (PAAA) and poly(acrylamide-co-propargyl acrylamide) (PAPA)] to present single peptides. Adhesion of hPSC colonies was more consistently observed on surfaces modified with cRGDfK compared to surfaces modified with other peptide sequences tested...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29335319/preterm-delivery-and-future-risk-of-maternal-cardiovascular-disease-a-systematic-review-and-meta-analysis
#10
REVIEW
Pensée Wu, Martha Gulati, Chun Shing Kwok, Chun Wai Wong, Aditya Narain, Shaughn O'Brien, Carolyn A Chew-Graham, Ganga Verma, Umesh T Kadam, Mamas A Mamas
BACKGROUND: Preterm delivery (<37 weeks gestational age) affects 11% of all pregnancies, but data are conflicting whether preterm birth is associated with long-term adverse maternal cardiovascular outcomes. We aimed to systematically evaluate and summarize the evidence on the relationship between preterm birth and future maternal risk of cardiovascular diseases. METHODS AND RESULTS: A systematic search of MEDLINE and EMBASE was performed to identify relevant studies that evaluated the association between preterm birth and future maternal risk of composite cardiovascular disease, coronary heart disease, stroke, and death caused by cardiovascular or coronary heart disease and stroke...
January 15, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29333692/measuring-spatial-and-temporal-trends-of-nicotine-and-alcohol-consumption-in-australia-using-wastewater-based-epidemiology
#11
Foon Yin Lai, Coral Gartner, Wayne Hall, Steve Carter, Jake O'Brien, Benjamin J Tscharke, Frederic Been, Cobus Gerber, Jason White, Phong Thai, Raimondo Bruno, Jeremy Prichard, K Paul Kirkbride, Jochen F Mueller
BACKGROUND AND AIMS: Tobacco and alcohol consumption remain priority public health issues worldwide. As participation in population-based surveys has fallen, it is increasingly challenging to estimate accurately the prevalence of alcohol and tobacco use. Wastewater-based epidemiology (WBE) is an alternative approach for estimating substance use at the population level that does not rely on survey participation. This study examined spatio-temporal patterns in nicotine (a proxy for tobacco) and alcohol consumption in the Australian population via WBE...
January 14, 2018: Addiction
https://www.readbyqxmd.com/read/29332754/conservative-management-of-thumb-carpometacarpal-osteoarthritis-an-italian-survey-of-current-clinical-practice
#12
Jorge Hugo Villafañe, Kristin Valdes, Virginia O'Brien, Monica Seves, Raquel Cantero-Téllez, Pedro Berjano
OBJECTIVE: The purpose of this study was to elucidate expert opinion on the conservative treatment of thumb carpometacarpal (CMC) joint osteoarthritis (OA). METHODS: A 21-item survey to determine the practice patterns of Italian hand therapists who treat arthritis of the CMC joint was developed and distributed through a professional online survey service to assure confidentiality and anonymity. RESULTS: Of the respondents, 80.8% were physical therapists; the remaining 19...
January 2018: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29331783/comparative-study-of-novel-in-situ-decorated-porous-chitosan-selenium-scaffolds-and-porous-chitosan-silver-scaffolds-towards-antimicrobial-wound-dressing-application
#13
Dhee P Biswas, Neil M O'Brien-Simpson, Eric C Reynolds, Andrea J O'Connor, Phong A Tran
Dermal defects caused by trauma or disease are challenging to treat due to difficult-to-treat infections that impair wound healing. Due to the widespread emergence of drug-resistant bacteria and dwindling discoveries of new antibiotics, there is currently an urgent need to introduce novel antimicrobials effective against antibiotic-resistant bacteria without causing damage to host tissues. As selenium (Se) and silver (Ag) are known for their antimicrobial properties, we investigated the separate loading of these materials into porous chitosan/PVA (CS) scaffolds through a simple in situ deposition method to create two distinct wound dressing materials (CS-Se and CS-Ag)...
January 5, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29331470/the-effect-of-different-precooling-rates-and-cold-storage-on-milk-microbiological-quality-and-composition
#14
Lizandra F Paludetti, Alan L Kelly, Bernadette O'Brien, Kieran Jordan, David Gleeson
The objective of this study was to measure the effect of different milk cooling rates, before entering the bulk tank, on the microbiological load and composition of the milk, as well as on energy usage. Three milk precooling treatments were applied before milk entered 3 identical bulk milk tanks: no plate cooler (NP), single-stage plate cooler (SP), and double-stage plate cooler (DP). These precooling treatments cooled the milk to 32.0 ± 1.4°C, 17.0 ± 2.8°C, and 6.0 ± 1.1°C, respectively. Milk was added to the bulk tank twice daily for 72 h, and the tank refrigeration temperature was set at 3°C...
January 10, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29330481/fdxr-is-a-biomarker-of-radiation-exposure-in-vivo
#15
Gráinne O'Brien, Lourdes Cruz-Garcia, Matthäus Majewski, Jakub Grepl, Michael Abend, Matthias Port, Aleš Tichý, Igor Sirak, Andrea Malkova, Ellen Donovan, Lone Gothard, Sue Boyle, Navita Somaiah, Elizabeth Ainsbury, Lucyna Ponge, Krzysztof Slosarek, Leszek Miszczyk, Piotr Widlak, Edward Green, Neel Patel, Mahesh Kudari, Fergus Gleeson, Volodymyr Vinnikov, Viktor Starenkiy, Sergii Artiukh, Leonid Vasyliev, Azfar Zaman, Christophe Badie
Previous investigations in gene expression changes in blood after radiation exposure have highlighted its potential to provide biomarkers of exposure. Here, FDXR transcriptional changes in blood were investigated in humans undergoing a range of external radiation exposure procedures covering several orders of magnitude (cardiac fluoroscopy, diagnostic computed tomography (CT)) and treatments (total body and local radiotherapy). Moreover, a method was developed to assess the dose to the blood using physical exposure parameters...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29330117/rifm-fragrance-ingredient-safety-assessment-phenethyl-isovalerate-cas-registry-number-140-26-1
#16
A M Api, D Belsito, D Botelho, D Browne, M Bruze, G A Burton, J Buschmann, M L Dagli, M Date, W Dekant, C Deodhar, M Francis, A D Fryer, K Joshi, S La Cava, A Lapczynski, D C Liebler, D O'Brien, R Parakhia, A Patel, T M Penning, G Ritacco, J Romine, D Salvito, T W Schultz, I G Sipes, Y Thakkar, E H Theophilus, A K Tiethof, Y Tokura, S Tsang, J Wahler
No abstract text is available yet for this article.
January 9, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29330101/telephone-based-weight-loss-support-for-patients-with-knee-osteoarthritis-a-pragmatic-randomized-controlled-trial
#17
Kate M O'Brien, John Wiggers, Amanda Williams, Elizabeth Campbell, Rebecca K Hodder, Luke Wolfenden, Sze Lin Yoong, Emma K Robson, Robin Haskins, Steven J Kamper, Chris Rissel, Christopher M Williams
OBJECTIVE: To determine the effectiveness of telephone-based weight loss support in reducing the intensity of knee pain in patients with knee osteoarthritis, who are overweight or obese, compared to usual care. DESIGN: We conducted a parallel randomized controlled trial (RCT), embedded within a cohort multiple RCT of patients on a waiting list for outpatient orthopaedic consultation at a tertiary referral hospital in NSW, Australia. Patients with knee osteoarthritis, classified as overweight or obese (body mass index between ≥27kg/m2 and <40kg/m2) were randomly allocated to receive referral to an existing non-disease specific government funded 6-month telephone-based weight management and healthy lifestyle service or usual care...
January 9, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29327428/an-endochondral-ossification-approach-to-early-stage-bone-repair-use-of-tissue-engineered-hypertrophic-cartilage-constructs-as-primordial-templates-for-weight-bearing-bone-repair
#18
Amos Matsiko, Emmet M Thompson, Cai Lloyd-Griffith, Gráinne M Cunniffe, Tatiana Vinardell, John P Gleeson, Daniel J Kelly, Fergal J O'Brien
Mimicking endochondral ossification to engineer constructs offers a novel solution to overcoming the problems associated with poor vascularisation in bone repair. This can be achieved by harnessing the angiogenic potency of hypertrophic cartilage. In this study, we demonstrate that tissue-engineered hypertrophically-primed cartilage constructs can be developed from collagen-based scaffolds cultured with mesenchymal stem cells. These constructs were subsequently implanted into femoral defects in rats. It was evident that the constructs could support enhanced early-stage healing at 4 weeks of these weight-bearing femoral bone defects compared to untreated defects...
January 11, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29327231/loading-of-the-condylar-cartilage-can-rescue-the-effects-of-botox-on-tmj
#19
Eliane H Dutra, Mara H O'Brien, Candice Logan, Aditya Tadinada, Ravindra Nanda, Sumit Yadav
The purpose of this study is to evaluate whether the effects of botulinum neurotoxin (botox) injection into the masseter in the mandibular condylar cartilage (MCC) and subchondral bone could be rescued by compressive loading of the temporomandibular joint (TMJ). Twenty-four 6-week-old female mice (C57BL/6J) were used. Mice were divided in three groups: (1) Botox (n = 8); (2) Botox plus loading (n = 8); (3) Pure control (n = 8). Bone labels (3 and 1 day before sacrifice) and the proliferation marker EdU (2 and 1 day before sacrifice) were intraperitoneally injected into all groups of mice...
January 11, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29325807/rifm-fragrance-ingredient-safety-assessment-dodecanenitrile-cas-registry-number-2437-25-4
#20
A M Api, D Belsito, D Botelho, D Browne, M Bruze, G A Burton, J Buschmann, M L Dagli, M Date, W Dekant, C Deodhar, M Francis, A D Fryer, K Joshi, S La Cava, A Lapczynski, D C Liebler, D O'brien, R Parakhia, A Patel, T M Penning, G Ritacco, J Romine, D Salvito, T W Schultz, I G Sipes, Y Thakkar, E H Theophilus, A K Tiethof, Y Tokura, S Tsang, J Wahler
No abstract text is available yet for this article.
January 8, 2018: Food and Chemical Toxicology
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