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JOURNAL ARTICLE
Jaskaran Singh, Narendra N Khanna, Ranjeet K Rout, Narpinder Singh, John R Laird, Inder M Singh, Mannudeep K Kalra, Laura E Mantella, Amer M Johri, Esma R Isenovic, Mostafa M Fouda, Luca Saba, Mostafa Fatemi, Jasjit S Suri
Due to the intricate relationship between the small non-coding ribonucleic acid (miRNA) sequences, the classification of miRNA species, namely Human, Gorilla, Rat, and Mouse is challenging. Previous methods are not robust and accurate. In this study, we present AtheroPoint's GeneAI 3.0, a powerful, novel, and generalized method for extracting features from the fixed patterns of purines and pyrimidines in each miRNA sequence in ensemble paradigms in machine learning (EML) and convolutional neural network (CNN)-based deep learning (EDL) frameworks...
March 26, 2024: Scientific Reports
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JOURNAL ARTICLE
Aakash Mahesan, Shweta Kedia, Gautam Kamila, Hena Khandakar, Vaishali Suri, Ajay Garg, Atin Kumar, Prashant Jauhari, Biswaroop Chakrabarty, Sheffali Gulati
No abstract text is available yet for this article.
April 23, 2024: Neurology
#23
JOURNAL ARTICLE
Taylor P Kohn, William DuComb, Kiran Sury, Una Choi, Trinity J Bivalacqua
INTRODUCTION: The objective of this study was to assess the rates of surgical shunting and prosthesis placement for acute ischemic priapism using a large multi-institutional claims database. METHODS: A US claims database network (TriNetX Diamond Network) was queried from 2010 to 2020. We constructed a cohort of men ages ≥ 16 years who (1) had a diagnosis of priapism and (2) underwent an irrigation of the corpora cavernosa for priapism. We assessed the number of men who then had a surgical penile shunt or penile prosthesis placement...
March 21, 2024: Urology Practice
#24
JOURNAL ARTICLE
Anuradha Dutta, Shweta Suri, Meenal Rai, Rushda Anam Malik, Ranjana Acharya, Pooja Pandey
This study identified determinants of malnutrition among school children in West Bengal, India. A total of 896 children aged between 4 and 13 years in eight districts were evaluated. BMI, weight, and height-for-age z-scores were used to categorize the stages of malnutrition. The study results revealed that the average height of the boys and girls was as per the standards set by the National Council of Health Sciences. Body mass index of the children ranged between 14.4 and 21.42 kg/m2 , and stunting was 56...
March 25, 2024: Ecology of Food and Nutrition
#25
JOURNAL ARTICLE
Suprit Basu, Rashmi Rikhi, Kanika Arora, Vibhu Joshi, Saniya Sharma, Amit Rawat, Surjit Singh, Deepti Suri
INTRODUCTION: Wiskott-Aldrich syndrome (WAS) is a rare X-linked inborn error of immunity characterized by microthrombocytopenia, infections, eczema, and increased predisposition to develop autoimmunity and malignancy. Flow cytometric assay for determining WAS protein (WASp) is a rapid and cost-effective tool for detecting patients. However, very few studies described WASp expression in female carriers. Most WAS carriers are clinically asymptomatic. Active screening of female family members helps identify female carriers, distinguish de novo mutations, and to select appropriate donor prior to curative stem cell transplantation...
March 24, 2024: Pediatric Blood & Cancer
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JOURNAL ARTICLE
Abhinav Suri, Stephen Avila, Christina Tan, Huda Alalami, Jennifer Harris
BACKGROUND: Facial paralysis due to parotid sialolithiasis-induced parotitis is a unusual clinical phenomenon that has not been reported in prior literature. This scenario can present a diagnostic challenge due to its rarity and complex symptomatology, particularly if a patient has other potential contributing factors such as facial trauma or bilateral forehead botox injections as in this patient. This case report elucidates such a complex presentation, aiming to increase awareness and promote timely recognition among clinicians...
March 22, 2024: BMC Neurology
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JOURNAL ARTICLE
Archana Sasi, Jyotsna Dandotiya, Jyotsana Kaushal, Shuvadeep Ganguly, Akshay Binayke, K M Ambika, Akshi Shree, Farhana Jahan, Priyanka Sharma, Tejas Menon Suri, Amit Awasthi, Sameer Bakhshi
BACKGROUND: Data on SARS-CoV-2 vaccine responsiveness in adolescent/young adult (AYA) cancer patients are sparse. The present study assessed humoral and cellular immune responses post-vaccination in this population. METHODS: In this prospective study, patients aged 12-30 years undergoing cancer therapy ("on therapy") and survivors ("off therapy") were recruited. Anti-receptor binding domain (RBD) protein IgG levels were measured at baseline, four weeks post-first vaccine dose (T1), and six weeks post-second dose (T2)...
March 20, 2024: Vaccine
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Andrew Renshaw, Nneoma Duru, Eric Assid, Gerard K Williams, Misty Suri, Deryk Jones
Background: An osteochondral defect in the hip can be a painful and limiting pathologic process. The damaged joint may progress into premature osteoarthritis, further limiting a patient's functionality. Case Report: A 24-year-old male presented to the clinic with left hip pain. The patient had been involved in a motor vehicle accident 3 years prior to presentation to our clinic. His injury from the high-speed accident required intramedullary rod fixation for a right-sided (contralateral) subtrochanteric femur fracture...
2024: Ochsner Journal
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JOURNAL ARTICLE
Rajat Suri, Daniela Markovic, Han Woo, Mehrdad Arjomandi, R Graham Barr, Russell P Bowler, Gerard Criner, Jeffrey L Curtis, Mark T Dransfield, M Bradley Drummond, Spyridon Fortis, MeiLan K Han, Eric A Hoffman, Robert J Kaner, Joel D Kaufman, Jerry A Krishnan, Fernando J Martinez, Jill Ohar, Victor E Ortega, Robert Paine Iii, Xavier Soler, Prescott G Woodruff, Nadia N Hansel, Christopher B Cooper, Donald P Tashkin, Russell G Buhr, Igor Z Barjaktarevic
RATIONALE: Individuals with COPD have airflow obstruction and maldistribution of ventilation. For those living at high altitude, any gas exchange abnormality is compounded by reduced partial pressures of inspired oxygen. OBJECTIVES: Does residence at higher-altitude exposure affect COPD outcomes, including lung function, imaging characteristics, symptoms, health status, functional exercise capacity, exacerbations, or mortality? METHODS: From the SPIROMICS cohort, we identified individuals with COPD living below 1,000 ft (305 m) elevation (n= 1,367) versus above 4,000 ft (1,219 m) elevation (n= 288)...
March 20, 2024: American Journal of Respiratory and Critical Care Medicine
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JOURNAL ARTICLE
Daria E A Jensen, Klaus P Ebmeier, Sana Suri, Matthew F S Rushworth, Miriam C Klein-Flügge
The hypothalamus is part of the hypothalamic-pituitary-adrenal axis which activates stress responses through release of cortisol. It is a small but heterogeneous structure comprising multiple nuclei. In vivo human neuroimaging has rarely succeeded in recording signals from individual hypothalamus nuclei. Here we use human resting-state fMRI (n = 498) with high spatial resolution to examine relationships between the functional connectivity of specific hypothalamic nuclei and a dimensional marker of prolonged stress...
March 18, 2024: Nature Communications
#31
JOURNAL ARTICLE
Prithvi Singh, Rubi Solanki, Alvea Tasneem, Simran Suri, Harleen Kaur, Sapna Ratan Shah, Ravins Dohare
BACKGROUND: The hepatocellular carcinoma (HCC) incident rate is gradually increasing yearly despite all the research and efforts taken by scientific communities and governing bodies. Approximately 90% of all liver cancer cases belong to HCC. Usually, HCC patients approach the treatment in the late stages of this malignancy which becomes the primary cause of high mortality rate. The knowledge about molecular pathogenesis of HCC is limited and needs more attention from researchers to identify the driver genes and miRNAs, which causes to translate this information into clinical practice...
March 2024: Journal, Genetic Engineering & Biotechnology
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JOURNAL ARTICLE
Sadia Suri, Saira Saeed Khan, Sadaf Naeem, Zeb Un Nisa, Nausheen Alam, Saba Majeed, Suresh Kumar, Rafeeq Alam Khan
Allium Cepa Linn. (Onions) has extensively been used in traditional medicine, is one of the important Allium species regularly used in our daily diet, and has been the source of robust phenolic compounds. The current study is intended to evaluate the fecundity-enhancing effect of A. Cepa on the reproductive performance of two successive generations of rats; F0 and F1. A. Cepa extract was initially tested for in vitro antioxidant assay via DPPH and ROS, followed by in vivo toxicity testing. In the fecundity assessment, eighteen pairs of male and female rats (n = 36, 1:1, F0 generation) were divided into three groups and dosed with 75mg/kg and 150 mg/kg daily of A...
2024: PloS One
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JOURNAL ARTICLE
Riccardo Cau, Francesco Pisu, Giuseppe Muscogiuri, Sandro Sironi, Jasjit S Suri, Gianluca Pontone, Rodrigo Salgado, Luca Saba
OBJECTIVE: Our study aimed to explore with cardiovascular magnetic resonance (CMR) the impact of left atrial (LA) and left ventricular (LV) myocardial strain in patients with acute pericarditis and to investigate their possible prognostic significance in adverse outcomes. METHOD: This retrospective study performed CMR scans in 36 consecutive patients with acute pericarditis (24 males, age 52 [23-52]). The primary endpoint was the combination of recurrent pericarditis, constrictive pericarditis, and surgery for pericardial diseases defined as pericardial events...
March 11, 2024: European Radiology
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JOURNAL ARTICLE
Riccardo Cau, Francesco Pisu, Alessandra Pintus, Vitanio Palmisano, Roberta Montisci, Jasjit S Suri, Rodrigo Salgado, Luca Saba
OBJECTIVE: This work aimed to derive a machine learning (ML) model for the differentiation between ischemic cardiomyopathy (ICM) and non-ischemic cardiomyopathy (NICM) on non-contrast cardiovascular magnetic resonance (CMR). METHODS: This retrospective study evaluated CMR scans of 107 consecutive patients (49 ICM, 58 NICM), including atrial and ventricular strain parameters. We used these data to compare an explainable tree-based gradient boosting additive model with four traditional ML models for the differentiation of ICM and NICM...
March 7, 2024: European Radiology
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JOURNAL ARTICLE
Francisco Mesonero, Yamile Zabana, Agnès Fernández-Clotet, Eduardo Leo-Carnerero, Berta Caballol, Andrea Núñez-Ortiz, María José García, Federico Bertoletti, Alejandro Mínguez, Gerard Suris, Begoña Casis, Rocío Ferreiro-Iglesias, Margalida Calafat, Itxaso Jiménez, José Miranda-Bautista, Luis Javier Lamuela, Ingrid Fajardo, Leyanira Torrealba, Rodrigo Nájera, Rosa María Sáiz-Chumillas, Irene González, Miren Vicuña, Natalia García-Morales, Ana Gutiérrez, Alicia López-García, José Manuel Benítez, Cristina Rubín de Célix, Coral Tejido, Eduard Brunet, Alejandro Hernández-Camba, Cristina Suárez, Iago Rodríguez-Lago, Marta Piqueras, Andrés Castaño, Laura Ramos, Ana Sobrino, María Carmen Rodríguez-Grau, Alfonso Elosua, Miguel Montoro, Ruth Baltar, José María Huguet, Benito Hermida, Antonio Caballero-Mateos, Luis Sánchez-Guillén, Abdel Bouhmidi, Ramón Pajares, Iria Baston-Rey, Antonio López-Sanromán, Agustin Albillos, Manuel Barreiro-de Acosta
BACKGROUND: The usefulness of thiopurines has been poorly explored in pouchitis and other pouch disorders. OBJECTIVE: To evaluate the effectiveness and safety of azathioprine as maintenance therapy in inflammatory pouch disorders. DESIGN: This was a retrospective and multicentre study. METHODS: We included patients diagnosed with inflammatory pouch disorders treated with azathioprine in monotherapy. Effectiveness was evaluated at 1 year and in the long term based on normalization of stool frequency, absence of pain, faecal urgency or fistula discharge (clinical remission), or any improvement in these symptoms (clinical response)...
2024: Therapeutic Advances in Gastroenterology
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JOURNAL ARTICLE
Narges Hassanpoor, Nazanin Ebrahimiadib, Hamid Riazi-Esfahani, Afrooz Moghaddasi, Fatemeh Suri
BACKGROUND: To describe different clinical presentations of a same NR2E3 recessive mutation in two families and within one family. DESIGN: Interventional family study. RESULTS: Our first case was a one-year-old male child with high hyperopia and refractive accommodative esotropia. In retinal examination, peri-papillary sub-retinal fibrosis with a helicoid configuration was observed in both eyes. The parents and the only sibling had no pathologic findings in the eyes...
March 5, 2024: European Journal of Ophthalmology
#37
JOURNAL ARTICLE
Saurabh Gupta, Amol Raheja, Sarvesh Goyal, Kanwaljeet Garg, Vivek Tandon, Sumanta Das, Vaishali Suri
No abstract text is available yet for this article.
January 1, 2024: Neurology India
#38
JOURNAL ARTICLE
Fatemeh Suri, Abdullah Biginaloo, Mehdi Ghadimi, Hossein Dehghan Banadaki, Seyyed Hassan Paylakhi, Mozhgan Rezaei Kanavi
BACKGROUND: A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) is a superfamily of extracellular proteinases found in both mammals and invertebrates. Although there is some evidence about the role of ADAMTSs in ocular diseases such as glaucoma and ectopia lentis, but there is little information about the expression patterns of ADAMTS-1-20 and ADAMTS-like ( ADAMTSL-1-6 and PAPLN ) genes in human ocular tissues. This study aimed to evaluate the expression profiling of ADAMTS (L) superfamily of genes in different ocular tissues based on age...
December 2023: Iranian Journal of Public Health
#39
JOURNAL ARTICLE
Gavino Faa, Vassilios Fanos, Mirko Manchia, Peter Van Eyken, Jasjit S Suri, Luca Saba
The theory of fetal programming of adult diseases was first proposed by David J.P. Barker in the eighties of the previous century, to explain the higher susceptibility of some people toward the development of ischemic heart disease. According to his hypothesis, poor maternal living conditions during gestation represent an important risk factor for the onset of atherosclerotic heart disease later in life. The analysis of the early phases of fetal development is a fundamental tool for the risk stratification of children and adults, allowing the identification of susceptible or resistant subjects to multiple diseases later in life...
January 2024: Journal of Public Health Research
#40
Aakash Mahesan, Abin Sheref Mohammed, Gautam Kamila, Prashant Jauhari, Biswaroop Chakrabarty, Sumanta Das, Prasenjit Das, Vaishali Suri, Sudesh Gourav, Immaculata Xess, Atin Kumar, Sheffali Gulati
A 3-year-old boy presented with acute headache, vomiting and right focal clonic seizures without history of fever, joint pain or altered sensorium. Neuroimaging showed multifocal contrast enhancing lesions with significant perilesional edema. CECT chest and abdomen showed multiple variable sized nodules in the lungs and hypodense lesion in liver with mesenteric lymphadenopathy. There was persistent eosinophilia with maximum upto 35 %. Liver biopsy and brain biopsy revealed Cladophialophora bantiana. He was treated with IV liposomal amphotericin and voriconazole for 6 weeks with repeat neuroimaging showing more than 50 % resolution of the intracranial lesions...
February 24, 2024: Journal de Mycologie Médicale
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