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https://www.readbyqxmd.com/read/29146135/multivalent-oleanolic-acid-human-serum-albumin-conjugate-as-nonglycosylated-neomucin-for-influenza-virus-capture-and-entry-inhibition
#1
Yang Yang, Hao-Jie He, Hao Chang, Yao Yu, Mei-Bing Yang, Yun He, Zhen-Chuan Fan, Suri S Iyer, Peng Yu
We report the synthesis of multivalent oleanolic acid (OA) protein conjugates as nonglycosylated neomucin mimic for the capture and entry inhibition of influenza viruses. Oleanolic acid derivatives bearing an amine-terminated linker were synthesized by esterification of carboxylic acid and further grafted onto the human serum albumin (HSA) via diethyl squarate method. The binding of hemagglutinin (HA) on the virion surface to the synthetic neomucin was evaluated by hemagglutination inhibition assay. The influenza virus capture ability of the PEGylated OA-HSA conjugate was further investigated by Dynamic Light Scattering (DLS), virus capture assay and Isothermal Titration Calorimeter (ITC) techniques...
October 28, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29141504/to-treat-or-not-to-treat-microfilaria-detected-in-pap-smear
#2
Rashmi Bagga, Japleen Kaur, Vikas Suri, Raje Nijhawan, Nalini Gupta
No abstract text is available yet for this article.
January 1, 2017: Tropical Doctor
https://www.readbyqxmd.com/read/29133693/proliferation-in-meningiomas-introducing-objectivity-in-assessment
#3
Sujata Chaturvedi, Vaishali Suri
No abstract text is available yet for this article.
November 2017: Neurology India
https://www.readbyqxmd.com/read/29128572/mitral-valve-repair-robotic-and-other-minimally-invasive-approaches
#4
REVIEW
Mateo Marin Cuartas, Hoda Javadikasgari, Bettina Pfannmueller, Joerg Seeburger, A Marc Gillinov, Rakesh M Suri, Michael A Borger
Robotic and minimally invasive mitral valve (MV) procedures have been performed with increasing frequency over time. These alternatives offer similar efficacy to that achieved via standard median sternotomy, particularly in large volume centers, along with low perioperative morbidity and mortality rates. Moreover, patient acceptance is oftentimes increased due to less postoperative pain and shorter recovery times, as well as superior cosmetic results. However, these techniques are technically complex and associated with a significant learning curve...
November 8, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29128570/outcomes-in-degenerative-mitral-regurgitation-current-state-of-the-art-and-future-directions
#5
REVIEW
Milind Y Desai, Francesco Grigioni, Marco Di Eusanio, Matteo Saccocci, Maurizio Taramasso, Francesco Maisano, Rakesh M Suri, A Marc Gillinov
Mitral regurgitation (MR) is the one of the most frequent valvular heart diseases in the developed world, often requiring surgical correction. Degenerative MR is the most common type of non-ischemic, organic MR in the western world. Since no medical treatment has been shown to be effective in preventing the consequences of volume overload in asymptomatic degenerative MR, risk stratification is essential. Currently, this is achieved using clinical and precisely quantified echocardiographic parameters, with newer technologies like cardiac magnetic resonance gaining increasing prominence...
November 8, 2017: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29124425/steroid-hormones-in-environmental-matrices-extraction-method-comparison
#6
Gangadhar Andaluri, Rominder P S Suri, Kendon Graham
The U.S. Environmental Protection Agency (EPA) has developed methods for the analysis of steroid hormones in water, soil, sediment, and municipal biosolids by HRGC/HRMS (EPA Method 1698). Following the guidelines provided in US-EPA Method 1698, the extraction methods were validated with reagent water and applied to municipal wastewater, surface water, and municipal biosolids using GC/MS/MS for the analysis of nine most commonly detected steroid hormones. This is the first reported comparison of the separatory funnel extraction (SFE), continuous liquid-liquid extraction (CLLE), and Soxhlet extraction methods developed by the U...
November 9, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29120030/risk-behaviours-among-native-and-immigrant-youths-in-switzerland-a-cross-sectional-study
#7
Lorenzo Campisi, André Berchtold, Yara Barrense-Dias, Christina Akre, Mario Gehri, Joan-Carles Suris
QUESTION UNDER STUDY: Switzerland has been receiving migrants of various origins for more than 50 years. The adoption of risk-taking behaviours among migrant youths is unclear. Moreover, when studied, migrant youths are rarely analysed according to whether they are first or second generation, or just young people with mixed origins. The aim of this study was to assess whether there are any differences between first-and second-generation immigrants, youths of mixed origins and their native peers in Switzerland concerning their engagement in risk behaviours...
November 9, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29109629/peripartum-hysterectomy-in-a-tertiary-care-hospital-epidemiology-and-outcomes
#8
Bharti Sharma, Pooja Sikka, Vanita Jain, Kajal Jain, Rashmi Bagga, Vanita Suri
Background and Aims: Peripartum hysterectomy is associated with significant maternal morbidity and mortality. We reviewed all peripartum hysterectomies at our institute over a 1-year period. The aim of this study was to determine the incidence, surgery and anesthesia-related issues of peripartum hysterectomies and to compare outcomes of emergency and electively planned peripartum hysterectomies. Material and Methods: This was a retrospective analysis of records of women who underwent emergency or elective peripartum hysterectomy in a tertiary care hospital...
July 2017: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/29108796/multifunctional-neuroprotective-effect-of-withanone-a-compound-from-withania-somnifera-roots-in-alleviating-cognitive-dysfunction
#9
Anjali Pandey, Sarang Bani, Prabhu Dutt, Naresh Kumar Satti, Krishan Avtar Suri, Ghulam Nabi Qazi
Alzheimer's disease (AD) is a chronic disorder that slowly worsens and impairs the person's memory, learning, reasoning, judgment, communication and familiar tasks with loss of orientation. AD is characterized clinically by cognitive deficit and pathologically by the deposition of β amyloid plaques, neurofibrillary tangles, associated with degeneration of the cholinergic forebrain. Withanone (WS-2), a compound isolated from root extract of Withania somnifera at doses administered orally/day to wistar rats for duration of 21 days showed significant improvement in the cognitive skill by inhibiting amyloid β-42 and attenuated the elevated levels of pro-inflammatory cytokines like TNF alpha, IL-1 beta, IL-6, MCP-1, Nitric oxide, lipid peroxidation and both β- and γ- secretase enzymatic activity...
November 3, 2017: Cytokine
https://www.readbyqxmd.com/read/29107894/web-based-accurate-measurements-of-carotid-lumen-diameter-and-stenosis-severity-an-ultrasound-based-clinical-tool-for-stroke-risk-assessment-during-multicenter-clinical-trials
#10
Luca Saba, Sumit K Banchhor, Narendra D Londhe, Tadashi Araki, John R Laird, Ajay Gupta, Andrew Nicolaides, Jasjit S Suri
BACKGROUND: This pilot study presents a completely automated, novel, smart, cloud-based, point-of-care system for (a) carotid lumen diameter (LD); (b) stenosis severity index (SSI) and (c) total lumen area (TLA) measurement using B-mode ultrasound. The proposed system was (i) validated against manual reading taken by the Neurologist and (ii) benchmarked against the commercially available system. METHOD: One hundred patients (73 M/27 F, mean age: 68 ± 11 years), institutional review board approved, written informed consent, consisted of left/right common carotid artery (200 ultrasound scans) were acquired using a 7...
October 23, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29102464/partial-nephrectomy-versus-thermal-ablation-for-clinical-stage-t1-renal-masses-systematic-review-and-meta-analysis-of-more-than-3-900-patients
#11
REVIEW
J Ricardo Rivero, Jose De La Cerda, Hanzhang Wang, Michael A Liss, Ann M Farrell, Ronald Rodriguez, Rajeev Suri, Dharam Kaushik
PURPOSE: A systematic review and meta-analysis of clinical trials was undertaken to compare percutaneous thermal ablation versus partial nephrectomy (PN) for stage T1 renal tumors. MATERIALS AND METHODS: A comprehensive search of major databases was conducted from October 2000 to July 2016. Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines were followed. Incidences of all-cause mortality (ACM), cancer-specific mortality (CSM), local recurrence (LR), and metastases, as well as complication rates and changes in estimated glomerular filtration rate (eGFR), were evaluated...
November 1, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29100114/wall-based-measurement-features-provides-an-improved-ivus-coronary-artery-risk-assessment-when-fused-with-plaque-texture-based-features-during-machine-learning-paradigm
#12
Sumit K Banchhor, Narendra D Londhe, Tadashi Araki, Luca Saba, Petia Radeva, John R Laird, Jasjit S Suri
BACKGROUND: Planning of percutaneous interventional procedures involves a pre-screening and risk stratification of the coronary artery disease. Current screening tools use stand-alone plaque texture-based features and therefore lack the ability to stratify the risk. METHOD: This IRB approved study presents a novel strategy for coronary artery disease risk stratification using an amalgamation of IVUS plaque texture-based and wall-based measurement features. Due to common genetic plaque makeup, carotid plaque burden was chosen as a gold standard for risk labels during training-phase of machine learning (ML) paradigm...
October 23, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29094154/racial-differences-in-prevalence-and-risk-for-intracranial-atherosclerosis-in-a-us-community-based-population
#13
Ye Qiao, Fareed K Suri, Yiyi Zhang, Li Liu, Rebecca Gottesman, Alvaro Alonso, Eliseo Guallar, Bruce A Wasserman
Importance: Intracranial atherosclerotic disease (ICAD) is an important cause of stroke; however, little is known about racial differences in ICAD prevalence and its risk factors. Objective: To determine racial differences in ICAD prevalence and the risk factors (both midlife and concurrent) associated with its development in a large, US community-based cohort. Design, Setting, and Participants: Analysis of 1752 black and white participants recruited from the Atherosclerosis Risk in Communities (ARIC) cohort study who underwent 3-dimensional intracranial vessel wall magnetic resonance imaging from October 18, 2011 to December 30, 2013; data analysis was performed from October 18, 2011 to May 13, 2015...
November 1, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/29074046/mitral-valve-surgery-in-the-us-veterans-administration-health-system-10-year-outcomes-and-trends
#14
Faisal G Bakaeen, A Laurie Shroyer, Marco A Zenati, Vinay Badhwar, Vinod H Thourani, James S Gammie, Rakesh M Suri, Joseph F Sabik, A Marc Gillinov, Danny Chu, Shuab Omer, Mary T Hawn, G Hossein Almassi, Lorraine D Cornwell, Frederick L Grover, Todd K Rosengart, Laura Graham
OBJECTIVE: To compare mitral valve repair (MVRepair) and mitral valve replacement (MVReplace) trends in the Veterans Affairs (VA) Surgical Quality Improvement Program. METHODS: Trends were compared by bivariate analyses, followed by backward stepwise selection and multivariable logistic modeling to determine the effect of preoperative comorbidities and facility-level factors on MVRepair (vs MVReplace) rate. A subgroup analysis focused on patients who underwent elective surgery for isolated primary degenerative mitral regurgitation...
September 30, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29073064/human-shmt-inhibitors-reveal-defective-glycine-import-as-a-targetable-metabolic-vulnerability-of-diffuse-large-b-cell-lymphoma
#15
Gregory S Ducker, Jonathan M Ghergurovich, Nello Mainolfi, Vipin Suri, Stephanie K Jeong, Sophia Hsin-Jung Li, Adam Friedman, Mark G Manfredi, Zemer Gitai, Hahn Kim, Joshua D Rabinowitz
The enzyme serine hydroxymethyltransferse (SHMT) converts serine into glycine and a tetrahydrofolate-bound one-carbon unit. Folate one-carbon units support purine and thymidine synthesis, and thus cell growth. Mammals have both cytosolic SHMT1 and mitochondrial SHMT2, with the mitochondrial isozyme strongly up-regulated in cancer. Here we show genetically that dual SHMT1/2 knockout blocks HCT-116 colon cancer tumor xenograft formation. Building from a pyrazolopyran scaffold that inhibits plant SHMT, we identify small-molecule dual inhibitors of human SHMT1/2 (biochemical IC50 ∼ 10 nM)...
October 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29062560/use-of-a-minimally-invasive-cardiac-output-monitor-to-optimise-haemodynamics-in-a-patient-with-mitral-valve-disease-undergoing-cerebrovascular-surgery
#16
Ali M Al-Mashani, Niranjan D Waje, Neeraj Salhotra, Samaresh Das, Neelam Suri, Rashid A Al-Sheheimi, Nilay Chatterjee
Patients with mitral valve disease undergoing cerebrovascular surgery face increased inherent risks due to their associated cardiac comorbidities. As such, the anaesthetic management of such patients is distinctly challenging. Simultaneous consideration of both the cerebrovascular and underlying cardiac conditions determines key anaesthetic issues, as fluids and vasopressors or inotropes need to be titrated according to haemodynamic variables in order to optimise cerebral blood flow without compromising cardiac function...
August 2017: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/29056531/concordance-between-direct-and-indirect-measurements-of-free-25-oh-vitamin-d
#17
Pilar Peris, Xavier Filella, Ana Monegal, Nuria Guañabens, Laura Foj, María Bonet, Dolors Boquet, Enrique Casado, Dacia Cerdá, Alba Erra, Carmen Gómez-Vaquero, Silvia Martínez, Nuria Montalá, Concepción Pittarch, Eduardo Kanterewicz, Miquel Sala, Xavier Suris, Josep L Carrasco
At present, data comparing the quantification methods for measurement of free vitamin D (direct assay [direct 25-OHDF] and estimated by calculation [calculated 25-OHDF]), are scarce. The aim of this study was to analyse the concordance between these two methods of 25-OHDF analysis (direct vs. calculated). METHODS: Serum values of total 25-OHD (25-OHDT), vitamin D binding protein (DBP) (by R&D Systems ELISA), calculated 25-OHDF (by DBP, albumin and 25-OHDT) and direct 25-OHDF (by DIAsource ELISA) were analysed in 173 healthy women (aged 35-45years)...
October 19, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29054258/comparative-approaches-for-classification-of-diabetes-mellitus-data-machine-learning-paradigm
#18
Md Maniruzzaman, Nishith Kumar, Md Menhazul Abedin, Md Shaykhul Islam, Harman S Suri, Ayman S El-Baz, Jasjit S Suri
BACKGROUND AND OBJECTIVE: Diabetes is a silent killer. The main cause of this disease is the presence of excessive amounts of metabolites such as glucose. There were about 387 million diabetic people all over the world in 2014. The financial burden of this disease has been calculated to be about $13,700 per year. According to the World Health Organization (WHO), these figures will more than double by the year 2030. This cost will be reduced dramatically if someone can predict diabetes statistically on the basis of some covariates...
December 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29046215/prospective-surveillance-of-device-associated-health-care-associated-infection-in-an-intensive-care-unit-of-a-tertiary-care-hospital-in-new-delhi-india
#19
Shilpee Kumar, Poornima Sen, Rajni Gaind, Pardeep Kumar Verma, Poonam Gupta, Prem Rose Suri, Sunita Nagpal, Anil Kumar Rai
BACKGROUND: Surveillance of health care-associated infections (HAIs) plays a key role in the hospital infection control program and reduction of HAIs. In India, most of the surveillance of HAIs is reported from private sector hospitals that do not depict the situation of government sector hospitals. Other studies do not confirm with the Centers for Disease Control and Prevention's (CDC) National Healthcare Safety Network (NHSN) surveillance criterion, or deal with ventilator-associated pneumonia (VAP) instead of ventilator-associated event (VAE)...
October 15, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/29033750/bilateral-quadratus-lumborum-block-for-postoperative-analgesia-in-a-von-hippel-lindau-syndrome-patient-undergoing-laparoscopic-radical-nephrectomy
#20
Gaurav Sindwani, Sandeep Sahu, Aditi Suri, Zakia Saeed
No abstract text is available yet for this article.
October 2017: Saudi Journal of Anaesthesia
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