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Gurpreet S Suri, Amritvir Kaur, Tapas Sen
Persistent development in nanomedicine has enabled successful nanosizing of most drug samples which, in turn, imparts remarkable properties to the drugs such as enhanced solubility and bioavailability for the applications in drug delivery. In this context, several review articles are available in scientific domain covering inorganic nanoparticles such as Au, Ag, SPIONs, Qdots, carbon nanotubes and graphene; however, this review covers the development of drug nanoparticles together with their possibilities and limitation from fabrication (bottom up vs top down) to application in drug delivery during the last 5 years...
October 19, 2016: Nanomedicine
Michele Porcu, Antonella Balestrieri, Paolo Siotto, Pierleone Lucatelli, Michele Anzidei, Jasjit S Suri, Fulvio Zaccagna, Giovanni Maria Argiolas, Luca Saba
Mood disorders (MD) are important and frequent psychiatric pathologies, and the management of the patients affected by thes conditions represent an important factor of disability and a huge problem in socialterms and an economic burden. The "in-vivo" studies can help researchers to understand the first events at the base of the development of the pathology and to identify the molecular and non-molecular targets of therapies, but theyhave strong limitations due to the fact that human brain circuitsthem selvesare difficult to be reproduced in animal models...
October 10, 2016: Neuroscience Letters
Alfred C Gellhorn, Pradeep Suri, Sean Rundell, Nathan Olafsen, M Jake Carlson, Steve Johnson, Adrielle Fry, Thiru Anaswammy, Christopher Gilligan, Bryan Comstock, Patrick Heagerty, Janna Friedly, Jeffrey G Jarvik
BACKGROUND: Minimal longitudinal data exist regarding the role of lumbar musculature in predicting back pain and function. In cross sectional study designs, there is often atrophy of the segmental multifidus muscle in subjects with low back pain compared with matched controls. However, the cross sectional design of these studies prevents drawing conclusions regarding whether lumbar muscle characteristics predict or modify future back pain or function. OBJECTIVE: The primary objective is to determine if the cross sectional area (CSA) of lumbar muscles predicts functional status or back pain at 6- or 12-month follow-up in older adults with spinal degeneration...
October 6, 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
Yang Yang, Hai-Peng Liu, Qun Yu, Mei-Bing Yang, De-Min Wang, Tian-Wei Jia, Hao-Jie He, Yun He, Hai-Xia Xiao, Suri S Iyer, Zhen-Chuan Fan, Xin Meng, Peng Yu
A new class of S-sialoside Human Serum Albumin (HSA) and Bovine Serum Albumin (BSA) conjugates were prepared to enhance the binding affinity to hemagglutinin (HA) and neuraminidase (NA). The valency of glycoconjugates was controlled by the reaction ratio of the S-sialoside monomer and protein. Hemagglutination inhibition assay showed that these synthetic glycoproteins have higher affinity to HA than the small clusters of sialosides with lower valency, due to multivalent effect and optimized three dimensional presentation of sialosides on the protein platform...
September 28, 2016: Carbohydrate Research
Puja Sahai, Geetika Singh, Dodul Mondal, Vaishali Suri, Pramod Kumar Julka
The solitary fibrous tumor of central nervous system is rare. Herein, a case of solitary fibrous tumor arising from sellar region is described. A 60-year-old man underwent subtotal excision of the tumor because of extensive infiltration of optical and vascular structures. In view of the presence of residual tumor, he was treated with adjuvant radiation therapy. After a follow-up period of 1 year, there was no progression of the lesion evident on magnetic resonance imaging of the brain. Solitary fibrous tumor should be considered as one of the differential diagnosis of a mass lesion arising in sellar region...
October 2016: Asian Journal of Neurosurgery
Vivek Tandon, Sumit Bansal, P Sarat Chandra, Ashish Suri, Manjari Tripathi, Mehar C Sharma, Avijit Sarkari, Ashok K Mahapatra
BACKGROUND: Ganglioglioma is a common seizure associated tumor. The goal of this study was to observe the postoperative outcome in patients with gangliogliomas. MATERIAL AND METHODS: A total 24 patients with gangliogliomas who underwent surgery at our institute from 2008 to 2011 were included. There were 13 males (54%) in our study. A retrospective analysis for the demographic profile, surgery and outcome was performed using STATA software. Literature on this subject was also reviewed, MEDLINE and PUBMED databases were searched...
October 2016: Asian Journal of Neurosurgery
Ashish Suri, Manjul Tripathi
No abstract text is available yet for this article.
September 30, 2016: Journal of Neurosurgery
Hector I Michelena, Rakesh M Suri, Ognjen Katan, Mackram F Eleid, Marie-Annick Clavel, Mathew J Maurer, Patricia A Pellikka, Douglas Mahoney, Maurice Enriquez-Sarano
BACKGROUND: Sex-related differences in morbidity and survival in bicuspid aortic valve (BAV) adults are fundamentally unknown. Contemporary studies portend excellent survival for BAV patients identified at early echocardiographic-clinical stages. Whether BAV adults incur a survival disadvantage throughout subsequent echocardiographic-clinical stages remains undetermined. METHODS AND RESULTS: Analysis was done of 3 different cohorts of consecutive patients with echocardiographic diagnosis of BAV identified retrospectively: (1) a community cohort of 416 patients with first BAV diagnosis (age 35±21 years, follow-up 16±7 years), (2) a tertiary clinical referral cohort of 2824 BAV adults (age 51±16 years, follow-up 9±6 years), and (3) a surgical referral cohort of 2242 BAV adults referred for aortic valve replacement (AVR) (age 62±14 years, follow-up 6±5 years)...
2016: Journal of the American Heart Association
J S Suri, D P Bergsma, M J Moravan, K Y Usuki, M T Milano
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
D P Bergsma, M J Moravan, J S Suri, K Y Usuki, D P Singh, M T Milano
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Janna L Friedly, Todd Edwards, Danielle Lavallee, Zoya Bauer, Una Makris, Srdj Nedeljkovic, Pradeep Suri, Jeffrey J Jarvik
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
Janna L Friedly, Bryan A Comstock, Christopher J Standaert, Srdj Nedeljkovic, David J Kennedy, David M Sibell, Pradeep Suri, Venu Akuthota, Thiru M Annaswamy, Zoya Bauer, Jeffrey J Jarvik
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
Faruku Bande, Siti Suri Arshad, Mohd Hair Bejo, Saeid Kadkhodaei, Abdul Rahman Omar
Bioinformatic analysis was used to predict antigenic B-cell and T-cell epitopes within the S1 glycoprotein of M41 and CR88 IBV strains. A conserved linear B-cell epitope peptide, YTSNETTDVTS(175-185), was identified in M41 IBV strains while three such epitopes types namely, VSNASPNSGGVD(279-290), HPKCNFRPENI(328-338), and NETNNAGSVSDCTAGT(54-69), were predicted in CR88 IBV strains. Analysis of MHCI binding peptides in M41 IBV strains revealed the presence of 15 antigenic peptides out of which 12 were highly conserved in 96-100% of the total M41 strains analysed...
2016: Advances in Bioinformatics
Nirmala Jagadish, Sumit Agarwal, Namita Gupta, Rukhsar Fatima, Sonika Devi, Vikash Kumar, Vaishali Suri, Rajive Kumar, Vitusha Suri, Trilok Chand Sadasukhi, Anju Gupta, Abdul S Ansari, Nirmal Kumar Lohiya, Anil Suri
BACKGROUND: Breast cancer is one of the leading cause of cancer-related deaths in women worldwide and increasing rapidly in developing countries. In the present study, we investigated the potential role and association of HSP70-2 with breast cancer. METHODS: HSP70-2 expression was examined in 154 tumor and 103 adjacent non-cancerous tissue (ANCT) specimens and breast cancer cell lines (MCF7, BT-474, SK-BR-3 and MDA-MB-231) by RT-PCR, quantitative-PCR, immunohistochemistry, Western blotting, flow cytometry and indirect immunofluorescence...
2016: Journal of Experimental & Clinical Cancer Research: CR
Fouzia Siraj, Varsha Dalal, Manveen Kaur, Kapil Suri
Radiation-induced sarcomas (RIS) or postirradiation sarcomas have been reported as a rare long-term complication of radiation therapy (RT). The survival benefit offered by radiotherapy has been masked by an increase in the incidence of these sarcomas, thus making radiotherapy a double-edged sword. RIS generally develop with a mean latency period of 10-15 years and encompass different histological types. We report a case of oral leiomyosarcoma with a rather short latency period of 4 years after the radiotherapy of the prior oral squamous cell carcinoma (OSCC) detected on fluorine-18 (18F)-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography/computed tomography (PET/CT)...
September 2016: World Journal of Nuclear Medicine
Saad Ullah, Omar Elbita, Mahmoud Abdelghany, Hassan Tahir, Puneet Tuli, Waseem Zaid Alkilani, Joshan Suri
Gram-negative bacterial endocarditis causes 5% of all bacterial endocarditis. Among gram-negative bacteria, Klebsiella species are rare causes of native valve endocarditis. Klebsiella oxytoca is an extremely rare subspecies that can infrequently cause endocarditis and is associated with poor outcome. We report a case of Klebsiella oxytoca endocarditis in an elderly man who initially presented with stroke but later developed sepsis and heart block secondary to endocarditis.
July 2016: Journal of Investigative Medicine High Impact Case Reports
Xin-Miao Huang, Hai-Xia Fu, Li Zhong, Jiang Cao, Samuel J Asirvatham, Larry M Baddour, M Rizwan Sohail, Vuyisile T Nkomo, Rick A Nishimura, Kevin L Greason, Rakesh M Suri, Paul A Friedman, Yong-Mei Cha
BACKGROUND: Lead-related or valve-related endocarditis can complicate cardiovascular implantable electronic device (CIED) infection in patients with both CIED and prosthetic valves. The objective of this study was to determine the outcomes of transvenous lead extraction for CIED infection in patients with prosthetic valves. METHODS AND RESULTS: We retrospectively screened 794 transvenous lead extraction procedures, between September 1, 2001 and August 31, 2012, at Mayo Clinic to identify patients with prosthetic valves who underwent lead extraction for infection...
September 2016: Circulation. Arrhythmia and Electrophysiology
Marie-Annick Clavel, Christophe Tribouilloy, Jean-Louis Vanoverschelde, Rodolfo Pizarro, Rakesh M Suri, Catherine Szymanski, Siham Lazam, Pablo Oberti, Hector I Michelena, Allan Jaffe, Maurice Enriquez-Sarano
BACKGROUND: Studies suggesting that B-type natriuretic peptide (BNP) may predict outcomes of mitral regurgitation (MR) are plagued by small size, inconsistent etiologies, and lack of accounting for shifting normal BNP ranges with age and sex. OBJECTIVES: This study assessed the effect of BNP activation on mortality in a large, multicenter cohort of patients with degenerative MR. METHODS: In 1,331 patients with degenerative MR, BNP was prospectively measured at diagnosis and expressed as BNPratio (ratio to upper limit of normal for age, sex, and assay)...
September 20, 2016: Journal of the American College of Cardiology
Rashmi Pilania, Pooja Sikka, Manoj K Rohit, Vanita Suri, Praveen Kumar
INTRODUCTION: Maternal diabetes mellitus is associated with an increased risk of fetal and neonatal morbidity and mortality. Usual screening tests have not proved to be good prognostic indicators of fetal distress. Fetal cardiodynamics is potentially a useful screening tool. AIM: To determine if cardiodynamics of the fetus differ in pregnancy with diabetes requiring insulin than those without and to determine whether cardiodynamics predict fetal and neonatal outcomes...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
Kalpana Kumari, Mehar C Sharma, Aanchal Kakkar, Prit B Malgulwar, Pankaj Pathak, Vaishali Suri, Chitra Sarkar, Sarat P Chandra, Mohammed Faruq, Rakesh K Gupta, Ravindra K Saran
BACKGROUND: Subependymal giant cell astrocytomas (SEGA) are slow-growing benign intraventricular tumors, the pathogenesis of which is debated. Recent studies have shown that tuberous sclerosis complex (TSC) 1 and TSC2 genes are linked to the mammalian target of rapamycin (mTOR) cell signaling pathway. We aimed to analyze TSC1 and TSC2 gene mutation, hamartin and tuberin protein expression, and protein expression of mTOR signaling cascade in a series of SEGA to determine their role in pathogenesis...
September 2016: Neurology India
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