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Dr Vishali Chandrasekhar, Dr Harpreet Singh, Dr Aravind Subramanian, Dr Deba Prasad Dhibhar, Dr Vikas Suri, Dr Ashish Bhalla
No abstract text is available yet for this article.
April 20, 2024: American Journal of Medicine
#2
JOURNAL ARTICLE
Tipu Khan, Mariyam Almas, Nargis Malik, Akansha Jalota, Shaifali Sharma, Sk Asif Ali, Kalpana Luthra, Vaishali Suri, Ashish Suri, Soumen Basak, Pankaj Seth, Kunzang Chosdol, Subrata Sinha
STAT1 (Signal Transducer and Activator of Transcription 1), belongs to the STAT protein family, essential for cytokine signaling. Ithas been reported to have either context dependent oncogenic or tumor suppressor roles in different tumors. Earlier, we demonstrated that Glioblastoma multiforme (GBMs) overexpressing FAT1, an atypical cadherin, had poorer outcomes. Overexpressed FAT1 promotes pro-tumorigenic inflammation, migration/invasion by downregulating tumor suppressor gene, PDCD4. Here, we demonstrate that STAT1 is a novel mediator downstream to FAT1, in downregulating PDCD4 in GBMs...
April 17, 2024: Cellular Signalling
#3
JOURNAL ARTICLE
Sebastiano Vacca, Michele Porcu, Matteo Piga, Lorenzo Mannelli, Elisabetta Chessa, Jasjit S Suri, Antonella Balestrieri, Alberto Cauli, Luca Saba
BACKGROUND AND PURPOSE: Systemic lupus erythematosus is a complex autoimmune disease known for its diverse clinical manifestations, including neuropsychiatric systemic lupus erythematosus, which impacts a patient's quality of life. Our aim was to explore the relationships among brain MR imaging morphometric findings, neuropsychiatric events, and laboratory values in patients with systemic lupus erythematosus, shedding light on potential volumetric biomarkers and diagnostic indicators for neuropsychiatric systemic lupus erythematosus...
April 18, 2024: AJNR. American Journal of Neuroradiology
#4
JOURNAL ARTICLE
Gábor Csukly, Boglárka Orbán-Szigeti, Karolin Suri, Réka Zsigmond, Levente Hermán, Viktória Simon, Anita Kabaji, Barnabás Bata, Péter Hársfalvi, Edit Vass, Éva Csibri, Kinga Farkas, János Réthelyi
BACKGROUND: Treatment effects of conventional approaches with antipsychotics or psychosocial interventions are limited when it comes to reducing negative and cognitive symptoms in schizophrenia. While there is emerging clinical evidence that new, augmented protocols based on theta-burst stimulation can increase rTMS efficacy dramatically in depression, data on similar augmented therapies are limited in schizophrenia. The different patterns of network impairments in subjects may underlie that some but not all patients responded to given stimulation locations...
April 17, 2024: Trials
#5
JOURNAL ARTICLE
Émilie Bortolussi-Courval, Tiina Podymow, Marisa Battistella, Emilie Trinh, Thomas A Mavrakanas, Lisa McCarthy, Joseph Moryousef, Ryan Hanula, Jean-François Huon, Rita Suri, Todd C Lee, Emily G McDonald
RATIONALE & OBJECTIVE: Patients treated with dialysis are commonly prescribed multiple medications (polypharmacy), including some potentially inappropriate medications (PIMs). PIMs are associated with an increased risk of medication harm (eg, falls, fractures, hospitalization). Deprescribing is a solution that proposes to stop, reduce, or switch medications to a safer alternative. Although deprescribing pairs well with routine medication reviews, it can be complex and time-consuming...
May 2024: Kidney medicine
#6
JOURNAL ARTICLE
Abhinav Suri, James Quinn, Raymond R Balise, Daniel J Feaster, Nabila El-Bassel, Andrew G Rundle
BACKGROUND: The accessibility of pharmacies has been associated with overall health and wellbeing. Past studies have suggested that low income and racial minority communities are underserved by pharmacies. However, the literature is inconsistent in finding links between area-level income or racial and ethnic composition and access to pharmacies. Here we aim to assess area-level spatial access to pharmacies across New York State (NYS), hypothesizing that Census Tracts with higher poverty rates and higher percentages of Black and Hispanic residents would have lower spatial access...
April 15, 2024: BMC Health Services Research
#7
JOURNAL ARTICLE
X Surís, M J Pueyo-Sánchez, A Ricart, A Naranjo, T Casanova, C Gómez-Vaquero, E Duaso, J M Cancio-Trujillo, J Sánchez-Martín, A Pérez-Mitru
OBJECTIVE: To assess the cost-effectiveness of Fracture Liaison Service (FLS) compared to the standard of care for secondary prevention of fragility fractures form the perspective of the Catalan Health Service. METHODS: Cost-utility assessment through a Markov model that simulated disease progression of a patients' cohort candidates to initiate antiosteoporotic treatment after a fragility fracture. A time horizon of 10 years and a 6-month duration per cycle was established...
April 12, 2024: Journal of Healthcare Quality Research
#8
REVIEW
Hudaib Muhammad, Malik Hurais, Zakir Syeda Javeria, Rabbani Samra, Gnanendran Dhanushan, Syed Abdul Rehman Shah, Suri Noor Fatima, Khan Javeria, Iqbal Arham, Hussain Nowal, Abdullah Muhammad, Kumar Satesh, Khatri Mahima, Varrassi Giustino
BACKGROUND: Propofol has been the gold standard for anesthesia induction and maintenance due to its rapid onset and favorable pharmacokinetic properties. However, the search for alternative agents with improved safety and efficacy has led to the emergence of ciprofol (HSK3486), a structural analog of propofol. This systematic review and meta-analysis aim to comprehensively assess the safety and efficacy of ciprofol compared to propofol for anesthesia induction and maintenance in adult patients undergoing surgical procedures...
April 11, 2024: J Anesth Analg Crit Care
#9
JOURNAL ARTICLE
Suresh Selvam, Padma Youron, Harpreet Singh, Ritu Shree, Vikas Suri, Manoj Goyal, Manish Modi, Ashish Bhalla
Chikungunya fever is an arboviral illness caused by chikungunya virus (CHIKV) and transmitted by the bite of Aedes aegypti and Aedes albopictus. It is an RNA virus belonging to the genus Alphavirus and family Togaviridae. We present a case series of three patients with chikungunya illness developing para/post-infectious myeloradiculoneuropathy.These patients developed neurological symptoms in the form of bilateral lower limb weakness with sensory and bowel involvement after the recovery from the initial acute episode of chikungunya fever...
March 14, 2024: Journal of the Neurological Sciences
#10
JOURNAL ARTICLE
Samantha Guinn, Benedict Kinny-Köster, Joseph A Tandurella, Jacob T Mitchell, Dimitrios N Sidiropoulos, Melanie Loth, Melissa R Lyman, Alexandra B Pucsek, Daniel J Zabransky, Jae W Lee, Emma Kartalia, Mili Ramani, Toni T Seppälä, Christopher Cherry, Reecha Suri, Haley Zlomke, Jignasha Patel, Jin He, Christopher L Wolfgang, Jun Yu, Lei Zheng, David P Ryan, David T Ting, Alec C Kimmelman, Anuj Gupta, Ludmila Danilova, Jennifer H Elisseeff, Laura D Wood, Genevieve Stein-O'Brien, Luciane T Kagohara, Elizabeth M Jaffee, Richard A Burkhart, Elana J Fertig, Jacquelyn W Zimmerman
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy characterized by an immunosuppressive tumor microenvironment enriched with cancer associated fibroblasts (CAFs). This study utilized a convergence approach to identify tumor cell and CAF interactions through the integration of single-cell data from human tumors with human organoid co-culture experiments. Analysis of a comprehensive atlas of PDAC single-cell RNA sequencing (scRNA-seq) data indicated that CAF density is associated with increased inflammation and epithelial-mesenchymal transition (EMT) in epithelial cells...
April 8, 2024: Cancer Research
#11
JOURNAL ARTICLE
Akhilesh Sharma, Devendra Singh Basera, Vikas Suri, Shubh Mohan Singh
BACKGROUND: Schizophrenia is a life-shortening disease. The standardized mortality ratio has been higher than that of the general population, and it has doubled what it was 3-4 decades ago. This rise is mostly attributed to the increased cardiovascular risk associated with high second-generation antipsychotic (SGA) use. Evidence from the first-generation antipsychotic (FGA) era shows a lower prevalence of hypertension (HTN) but data regarding SGAs is scarce. PURPOSE: The purpose of the study was to assess the prevalence of HTN and related factors using standardized methodology in patients with schizophrenia on treatment with SGAs...
January 2024: Annals of Neurosciences
#12
Harleen Sood, Nupur Pradhan, Harpreet Singh, Deba Prasad Dhibhar, Murali Krishna Bethanbhatla, Harsimran Kaur, Kirti Gupta, Vikas Suri, Ashish Bhalla
No abstract text is available yet for this article.
April 5, 2024: American Journal of Medicine
#13
REVIEW
Sukhraj Singh, Ramandeep Singh, Subodh Kumar, Ashish Suri
INTRODUCTION: High-fidelity visualization of anatomical organs is crucial for neurosurgical education, simulation, and planning. This becomes much more important for minimally invasive neurosurgical procedures. Realistic anatomical visualization can allow resident surgeons to learn visual cues and orient themselves with the complex 3D anatomy. Achieving full fidelity in 3D medical visualization is an active area of research, however, the prior reviews focus on the application area and lack the underlying technical principles...
April 3, 2024: World Neurosurgery
#14
JOURNAL ARTICLE
Harpreet Singh, Deba Prasad Dhibhar, Suresh Selvam, Vishal Kumar, Vikas Suri, Ashish Bhalla
No abstract text is available yet for this article.
April 2, 2024: American Journal of Tropical Medicine and Hygiene
#15
JOURNAL ARTICLE
Diya Surie, Katharine A Yuengling, Jennifer DeCuir, Yuwei Zhu, Adam S Lauring, Manjusha Gaglani, Shekhar Ghamande, Ithan D Peltan, Samuel M Brown, Adit A Ginde, Amanda Martinez, Nicholas M Mohr, Kevin W Gibbs, David N Hager, Harith Ali, Matthew E Prekker, Michelle N Gong, Amira Mohamed, Nicholas J Johnson, Vasisht Srinivasan, Jay S Steingrub, Aleda M Leis, Akram Khan, Catherine L Hough, William S Bender, Abhijit Duggal, Emily E Bendall, Jennifer G Wilson, Nida Qadir, Steven Y Chang, Christopher Mallow, Jennie H Kwon, Matthew C Exline, Nathan I Shapiro, Cristie Columbus, Ivana A Vaughn, Mayur Ramesh, Jarrod M Mosier, Basmah Safdar, Jonathan D Casey, H Keipp Talbot, Todd W Rice, Natasha Halasa, James D Chappell, Carlos G Grijalva, Adrienne Baughman, Kelsey N Womack, Sydney A Swan, Cassandra A Johnson, Cara T Lwin, Nathaniel M Lewis, Sascha Ellington, Meredith L McMorrow, Emily T Martin, Wesley H Self
IMPORTANCE: On June 21, 2023, the Centers for Disease Control and Prevention recommended the first respiratory syncytial virus (RSV) vaccines for adults aged 60 years and older using shared clinical decision-making. Understanding the severity of RSV disease in adults can help guide this clinical decision-making. OBJECTIVE: To describe disease severity among adults hospitalized with RSV and compare it with the severity of COVID-19 and influenza disease by vaccination status...
April 1, 2024: JAMA Network Open
#16
JOURNAL ARTICLE
Ankita Suri, Kevin K Y Hu, Tayyaba Younas, Geoff Dumsday, Victoria S Haritos
Lipid droplets (LD) are dynamic cellular organelles of ≈1 µm diameter in yeast where a neutral lipid core is surrounded by a phospholipid monolayer and attendant proteins. Beyond the storage of lipids, opportunities for LD engineering remain underdeveloped but they show excellent potential as new biomaterials. In this research, LD from yeast Saccharomyces cerevisiae is engineered to display mCherry fluorescent protein, Halotag ligand binding protein, plasma membrane binding v-SNARE protein, and carbonic anhydrase enzyme via linkage to oleosin, an LD anchoring protein...
April 2, 2024: Small
#17
JOURNAL ARTICLE
Taylor P Kohn, William DuComb, Kiran Sury, Una Choi, Trinity J Bivalacqua
No abstract text is available yet for this article.
April 2, 2024: Urology Practice
#18
JOURNAL ARTICLE
Tianwei Jia, Varma Saikam, Ying Luo, Xiaolin Sheng, Jieqiong Fang, Mukesh Kumar, Suri S Iyer
Early detection and viral concentration monitoring of human immunodeficiency virus in resource-poor settings are important to control disease spread and reduce mortality. Nucleic acid amplification tests are expensive for low-resource settings. Lateral flow antibody tests are not sensitive if testing is performed within 7-10 days, and these tests are not quantitative. We describe a signal enhancement technique based on fluorescent silica nanoparticles and bioorthogonal chemistries for the femtomolar detection of the HIV-1 p24 antigen...
March 26, 2024: ACS Omega
#19
JOURNAL ARTICLE
Priyanka Choudhary, Amit Kumar Mital, Rajat Gupta, Neha Suri, R B Jain, Sujata Sethi, Sudhansu Sekhar Baral
OBJECTIVES: To translate and validate Hindi version of Adolescent Peer Relation Instrument (APRI) and to evaluate burden of bullying victimization among school-going adolescents. METHODS: A school-based cross-sectional study was performed from July 2021 to June 2022 on 9th-12thclass students. Adolescent peer relation instrument was used to evaluate bullying victimization. Reliability and validity of tool, prevalence and strength of association was analyzed by appropriate statistical methods...
March 27, 2024: Indian Pediatrics
#20
REVIEW
Abarna Thangaraj, Reva Tyagi, Deepti Suri, Sudhir Gupta
Primary immune regulatory disorders (PIRDs) constitute a spectrum of inborn errors of immunity (IEIs) that are primarily characterized by autoimmunity, lymphoproliferation, atopy, and malignancy. In PIRDs, infections are infrequent compared to other IEIs. While susceptibility to infection primarily stems from antibody deficiency, it is sometimes associated with additional innate immune and T or NK cell defects. The use of immunotherapy and chemotherapy further complicates the immune landscape, increasing the risk of diverse infections...
March 17, 2024: Pathogens
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