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https://www.readbyqxmd.com/read/28750269/a-comparative-analysis-of-ante-and-postnatal-clinical-characteristics-of-extremely-premature-neonates-suffering-from-refractory-and-non-refractory-hypotension-is-early-clinical-differentiation-possible
#1
Rita P Verma, Shaeequa Dasnadi, Yuan Zhao, Hegang H Chen
BACKGROUND: About 25% of hypotensive ELBW infants are refractory to intravascular volume expansion and inotropic drugs (VI) and require hydrocortisone (HC). Such neonates suffer from complications of prolonged hypotension and extended therapy with VI. ELBW infants with refractory hypotension (RH) are clinically and biochemically indistinguishable from those who respond to VI. OBJECTIVE: Early identification and differentiation of ELBW infants susceptible to steroid dependent hypotension from those who respond to inotropic medications...
July 24, 2017: Early Human Development
https://www.readbyqxmd.com/read/28749784/concentrations-of-leptin-adiponectin-and-other-metabolic-parameters-in-non-obese-children-with-down-syndrome
#2
Nikhil Tenneti, Devi Dayal, Sheetal Sharda, Inusha Panigrahi, Mohammed Didi, Savita Verma Attri, Naresh Sachdeva, Anil Kumar Bhalla
BACKGROUND: Recent data indicates that adults with Down syndrome (DS) are at increased risk for cardiovascular disease (CVD) that significantly contributes to their morbidity and mortality. Although identification of cardiometabolic risk factors during childhood is desirable to design preventive interventions, the data on such risk factors in children with DS is scarce. The aim of this study was to study the cardiometabolic risk factors such as insulin resistance (IR), leptin and adiponectin concentrations, lipid abnormalities and leptin resistance in non-obese children with DS...
July 27, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28749321/design-and-implementation-of-an-affordable-public-sector-electronic-medical-record-in-rural-nepal
#3
Anant Raut, Chase Yarbrough, Vivek Singh, Bikash Gauchan, David Citrin, Varun Verma, Jessica Hawley, Dan Schwarz, Alex Harsha Bangura, Biplav Shrestha, Ryan Schwarz, Mukesh Adhikari, Duncan Maru
INTRODUCTION: Globally, electronic medical records are central to the infrastructure of modern healthcare systems. Yet the vast majority of electronic medical records have been designed for resource-rich environments and are not feasible in settings of poverty. Here we describe the design and implementation of an electronic medical record at a public sector district hospital in rural Nepal, and its subsequent expansion to an additional public sector facility.DevelopmentThe electronic medical record was designed to solve for the following elements of public sector healthcare delivery: 1) integration of the systems across inpatient, surgical, outpatient, emergency, laboratory, radiology, and pharmacy sites of care; 2) effective data extraction for impact evaluation and government regulation; 3) optimization for longitudinal care provision and patient tracking; and 4) effectiveness for quality improvement initiatives...
June 23, 2017: Journal of Innovation in Health Informatics
https://www.readbyqxmd.com/read/28748832/temporo-spatial-distribution-of-insecticide-resistance-in-indian-malaria-vectors-in-the-last-quarter-century-need-for-regular-resistance-monitoring-and-management
#4
REVIEW
Kamaraju Raghavendra, Poonam Sharma Velamuri, Vaishali Verma, Natarajan Elamathi, Tapan Kumar Barik, Rajendra Mohan Bhatt, Aditya Prasad Dash
The Indian vector control programme similar to other programmes in the world is still reliant on chemical insecticides. Anopheles culicifacies is the major vector out of six primary malaria vectors in India and alone contributes about 2/3 malaria cases annually; and per se its control is actually control of malaria in India. For effective management of vectors, current information on their susceptibility status to different insecticides is essential. In this review, an attempt was made to compile and present the available data on the susceptibility status of different malaria vector species in India from the last 2...
April 2017: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/28748373/novel-combination-of-salinomycin-and-resveratrol-synergistically-enhances-the-anti-proliferative-and-pro-apoptotic-effects-on-human-breast-cancer-cells
#5
Jayant Dewangan, Divya Tandon, Sonal Srivastava, Ajeet Kumar Verma, Ashok Yapuri, Srikanta Kumar Rath
Resveratrol (RES) is a natural polyphenol having anti-proliferative activity against breast cancer cells. RES in combination with other chemo modulatory agents, minimizes toxicity and increases efficacy of the treatment. Salinomycin (SAL), a monocarboxylic polyether ionophore is known for selectively targeting breast cancer stem cells. Purpose of the present study was to investigate whether RES in combination with SAL exerts synergistic anti-proliferative activity on breast cancer cells. We further evaluated the molecular mechanism behind SAL and RES mediated cell death...
July 26, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28745351/atmospheric-concentrations-and-gas-particle-partitioning-of-polycyclic-aromatic-hydrocarbons-pahs-and-nitro-pahs-at-indo-gangetic-sites
#6
Puneet Kumar Verma, Dinesh Sah, K Maharaj Kumari, Anita Lakhani
Aerosol samples in the dual-phase (gaseous and particulate) were collected simultaneously for the first time in Agra at a rural and a traffic dominated site during post-monsoon and winter seasons to investigate the gas-particle partitioning of polycyclic aromatic hydrocarbons (PAHs). The samples were collected using a high volume sampler on quartz micro-fiber filter papers and polyurethane foam plugs for particulate and gas phases respectively. The samples were extracted in a mixture of DCM and n-hexane. 16 priority PAHs and two nitro-PAHs were analyzed using gas chromatograph-mass spectrometry...
July 26, 2017: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/28744074/multimodality-imaging-of-vaginal-rhabdomyosarcoma
#7
Richa S Chauhan, Dheeraj K Singh, Bishwarup Guha, Ishan Kumar, Ashish Verma
Rhabdomyosarcoma (RMS) is a malignant mesenchymal tumor arising from the embryonal muscle cells (rhabdomyoblasts), and is the most common soft tissue sarcoma in children and young adults accounting for 4-6% of all malignancies in this age group. Though rare overall, embryonal rhabdomyosarcoma is the most common malignancy arising in the pediatric female genitourinary tract with sarcoma botryoides being the most common variant of the tumor. In young and adolescent individuals, the cervix and uterus are affected; whereas in infants, vaginal lesions are more common...
April 2017: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/28744059/effect-of-yoga-practices-on-micronutrient-absorption-in-urban-residential-school-children
#8
Anita Verma, Sanjay Shete, Dattatraya Kulkarni, Ranjeet Singh Bhogal
[Purpose] This study was conducted with a view to find out the effect of yoga practices on micronutrient absorption in urban residential school children. [Subjects and Methods] The study population comprised 66 urban school children aged 11-15 years staying in a residential school in Pune City, Maharashtra, India. A stratified random sampling method was used to divide the students into experimental and control groups. There were 33 students in experimental group and 33 students in control group. Both experimental and control groups were assessed for the status of zinc, copper, iron and magnesium at the baseline and at the end of 12 weeks of yoga training...
July 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28743422/editorial
#9
EDITORIAL
Peter J Bond, Chandra S Verma
No abstract text is available yet for this article.
September 2017: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/28741750/atypical-morphology-of-anogenital-warts-is-not-a-marker-of-atypical-histology-or-of-infection-to-the-high-risk-human-papillomavirus-genotypes
#10
Pankaj Kumar, Neetu Bhari, Vishal Gupta, V G Ramachandran, Sudheer Arava, Lalit Dar, Vinod K Sharma, Kaushal K Verma, Sada N Dwivedi, Somesh Gupta
BACKGROUND: The clinical morphology of anogenital warts may vary from flat, filiform, papular, or verrucous to giant condyloma acuminatum. Clinically atypical-looking genital warts may alarm the clinician because of their suspected malignant potential, which may cause anxiety, often leading to aggressive interventions. OBJECTIVE: To study if clinically atypical-looking anogenital warts are more likely to be premalignant or malignant as compared to typical warts...
July 25, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28741147/constipation-in-degenerative-cervico-thoracic-spine-myelopathy-a-simple-co-existence-or-a-complex-inter-relationship
#11
Anant Mehrotra, Janmejay Jamdar, Pradeep Sharma, Chaitanya Godbole, Suyash Singh, Kuntal Kanti Das, Abhai Verma, Kamlesh Singh Bhaisora, Jayesh Sardhara, Awadhesh Kumar Jaiswal, Rabi Narayan Sahu, Arun Kumar Srivastava, Sanjay Behari, Raj Kumar
PURPOSE: Identify factors affecting constipation and post surgical improvement in patients of myelopathy. METHODS: Sixty-four patients with myelopathy due to extradural spine pathologies (47 cervical; 17 thoracic spine, male:female-5.4:1 with mean age 46.16) underwent evaluation including Bristol stool scale (BSS), PFT and uroflowmetry. All cases were evaluated by gastroenterologist to rule out any intrinsic bowel disease. Chi-square test, Kruskal-Wallis/Mann-Whitney U test and Wilcoxon signed rank test were employed to ascertain statistical significance...
July 24, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28741112/investigation-of-naphthofuran-moiety-as-potential-dual-inhibitor-against-bace-1-and-gsk-3%C3%AE-molecular-dynamics-simulations-binding-energy-and-network-analysis-to-identify-first-in-class-dual-inhibitors-against-alzheimer-s-disease
#12
Akhil Kumar, Gaurava Srivastava, Swati Srivastava, Seema Verma, Arvind S Negi, Ashok Sharma
BACE-1 and GSK-3β are potential therapeutic drug targets for Alzheimer's disease. Recently, both the targets received attention for designing dual inhibitors for Alzheimer's disease. Until now, only two-scaffold triazinone and curcumin have been reported as BACE-1 and GSK-3β dual inhibitors. Docking, molecular dynamics, clustering, binding energy, and network analysis of triazinone derivatives with BACE-1 and GSK-3β was performed to get molecular insight into the first reported dual inhibitor. Further, we designed and evaluated a naphthofuran series for its ability to inhibit BACE-1 and GSK-3β with the computational approaches...
August 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28739782/co-administration-of-allopurinol-to-increase-anti-mycobacterial-efficacy-of-pyrazinamide-evaluation-in-a-whole-blood-bactericidal-activity-model
#13
Claire M Naftalin, Rupangi Verma, Meera Gurumurthy, Qingshu Lu, Matthew Zimmerman, Benjamin Chaik Meng Yeo, Kin Hup Tan, Wenwei Lin, Buduo Yu, Véronique Dartois, Nicholas I Paton
Co-administering pyrazinamide (PZA) with the xanthine oxidase inhibitor, allopurinol, increases systemic levels of the active metabolite, pyrazinoic acid (POA), but effects on bactericidal activity against tuberculosis are unknown. We randomized healthy volunteers to take a single dose of PZA (either 10mg/kg or 25mg/kg) and the same dose 7 days later co-administered with allopurinol (100mg daily, 2 days before to 1 day after PZA dose). Blood was drawn at intervals to 48 hours after each PZA dose and drug levels were measured using liquid chromatography-tandem mass spectrometry...
July 24, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28738231/sliding-strip-microfluidic-device-enables-elisa-on-paper
#14
Mohit S Verma, Maria-Nefeli Tsaloglou, Tyler Sisley, Dionysios Christodouleas, Austin Chen, Jonathan Milette, George M Whitesides
This article describes a 3D microfluidic paper-based analytical device that can be used to conduct an enzyme-linked immunosorbent assay (ELISA). The device comprises two parts: a sliding strip (which contains the active sensing area) and a structure surrounding the sliding strip (which holds stored reagents-buffers, antibodies, and enzymatic substrate-and distributes fluid). Running an ELISA involves adding sample (e.g. blood) and water, moving the sliding strip at scheduled times, and analyzing the resulting color in the sensing area visually or using a flatbed scanner...
July 19, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28736711/left-ventricular-pseudoaneurysm-as-a-complication-of-left-ventricular-summit-premature-ventricular-contraction-ablation
#15
Sanjay Dandamudi, Susan S Kim, Nishant Verma, S Chris Malaisrie, Roderick Tung, Bradley P Knight
No abstract text is available yet for this article.
May 2017: HeartRhythm Case Reports
https://www.readbyqxmd.com/read/28735114/determination-of-impurities-in-graphite-using-synchrotron-radiation-based-x-ray-fluorescence-spectrometry
#16
M Ghosh, K K Swain, P S Remya Devi, T A Chavan, A K Singh, M K Tiwari, R Verma
Determination of impurities namely Ca, Mn, Fe, Ni, Zn, Sr and Pb in graphite by energy dispersive X-ray fluorescence spectrometry is described using microfocused synchrotron radiation. The internal standard and standard addition methodologies were adopted for quantification and the results were compared with tube-based X-ray fluorescence spectrometry. Analysis of the results by the F and t-tests revealed their statistical equivalence. Synchrotron measurements improved the detection limits by an order of magnitude compared to the tube based technique...
July 14, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28733699/a-prospective-study-of-docetaxel-associated-pain-syndrome
#17
Nicholas Chiu, Liying Zhang, Rebecca Dent, Angie Giotis, Jenna van Draanen, Daniela Gallo-Hershberg, Leonard Chiu, Ronald Chow, Bo Angela Wan, Mark Pasetka, Jordan Stinson, Erica Stacey, Sunil Verma, Henry Lam, Edward Chow, Carlo DeAngelis
PURPOSE: To investigate the natural history of taxane-associated acute pain syndrome (TAPS) in a docetaxel patient cohort and to examine the long-term manifestation of TAPS. PATIENTS AND METHODS: For three consecutive treatment cycles, taxane-naive breast cancer patients completed diaries on days 1-7, 14, and 21 and telephone questionnaires 1, 3, 6, 9, and 12 months following treatment. Questionnaires to assess pain and interference were adapted from the Brief Pain Inventory...
July 22, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28733223/sequencing-of-fic1-bsep-and-mdr3-in-a-large-cohort-of-patients-with-cholestasis-revealed-a-high-number-of-different-genetic-variants
#18
Carola Dröge, Michele Bonus, Ulrich Baumann, Caroline Klindt, Elke Lainka, Simone Kathemann, Florian Brinkert, Enke Grabhorn, Eva-Doreen Pfister, Daniel Wenning, Alexander Fichtner, Daniel N Gotthardt, Karl Heinz Weiss, Patrick McKiernan, Ratna Dua Puri, I C Verma, Stefanie Kluge, Holger Gohlke, Lutz Schmitt, Ralf Kubitz, Dieter Häussinger, Verena Keitel
BACKGROUND&AIMS: The bile salt export pump (BSEP, ABCB11), multidrug resistance protein 3 (MDR3, ABCB4) and the ATPase familial intrahepatic cholestasis 1 (FIC1, ATP8B1) mediate bile formation. Mutations in these genes underlie cholestatic liver diseases ranging from intrahepatic cholestasis of pregnancy, benign recurrent intrahepatic cholestasis or low phospholipid-associated cholelithiasis to progressive familial intrahepatic cholestasis. METHODS: Coding exons with flanking intron regions of ATP8B1, ABCB11, and ABCB4 were sequenced in cholestatic patients with assumed genetic cause...
July 18, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28731934/long-term-evaluation-of-specular-microscopic-changes-following-nd-yag-iridotomy-in-chronic-primary-angle-closure-glaucoma-eyes
#19
Ramanjit Sihota, Esha Agarwal, Mathew James, Meena Verma, Lalit Kumar, Tanuj Dada, Viney Gupta, Kulwant Singh Kapoor
AIM: The aim of this study was to evaluate specular microscopy of chronic primary angle-closure glaucoma (CPACG) eyes at least 1 year after Nd:YAG iridotomy, and compare them with CPACG eyes without an iridotomy and age-matched, normal eyes. PATIENTS AND METHOD: Consecutive patients of CPACG at the Glaucoma service were screened. All patients underwent slit-lamp biomicroscopy, +90 D examination, and applanation tonometry. A total of 100 eyes of 100 consecutive patients of CPACG with an Nd:YAG iridotomy performed ≥1 year before, who met all inclusion/exclusion criteria, 60 consecutive CPACG eyes without an iridotomy, and 60 age and refraction-matched control eyes were enrolled...
July 20, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28731456/upregulation-of-tet-activity-with-ascorbic-acid-induces-epigenetic-modulation-of-lymphoma-cells
#20
N Shenoy, T Bhagat, E Nieves, M Stenson, J Lawson, G S Choudhary, T Habermann, G Nowakowski, R Singh, X Wu, A Verma, T E Witzig
The Ten Eleven Translocation (TET) enzymes have been found to be mutated in both diffuse large B-cell (DLBCL) and peripheral T-cell (PTCL) lymphomas resulting in DNA hypermethylation. Recent studies in embryonal stem cells showed that ascorbic acid (AA) is a cofactor for TET with a binding site at the catalytic domain, and enhances TET activity. We hypothesized that AA could potentially enhance TET activity in lymphoma cells to cause DNA demethylation, reactivate expression of tumor suppressor genes and enhance chemosensitivity...
July 21, 2017: Blood Cancer Journal
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