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https://www.readbyqxmd.com/read/28214339/turner-syndrome-and-duchenne-muscular-dystrophy
#1
Sumit Verma, Parul Goyal, Charlotte Beam, Durga Shah
No abstract text is available yet for this article.
February 18, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28213924/diagnostic-paradox-ruptured-aneurysm-of-sinus-of-valsalva-simulating-tricuspid-valve-endocarditis
#2
Mehar Hoda, Arushi Verma, Sridevi Alapati, Srilatha Alapati, Tharakanatha R Yarrabolu
Rupture of aneurysm of sinus of Valsalva into the right atrium mimicking tricuspid valve endocarditis is a rare presentation. We review a case of spontaneous rupture of aneurysm of sinus of Valsalva into the right atrium presenting as a murmur. Transthoracic echocardiogram showed a mobile mass that appeared to be attached to the tricuspid valve leaflet with moderate tricuspid regurgitation suggestive of tricuspid valve endocarditis. The diagnosis was confirmed as spontaneous rupture of noncoronary sinus in to the right atrium by transesophageal echocardiogram...
February 18, 2017: Echocardiography
https://www.readbyqxmd.com/read/28213843/effect-of-biofeedback-therapy-on-anorectal-physiological-parameters-among-patients-with-fecal-evacuation-disorder
#3
Abhai Verma, Asha Misra, Uday C Ghoshal
BACKGROUND: Though biofeedback therapy is often effective in patients with fecal evacuation disorder (FED), a common cause of chronic constipation (CC) in tertiary practice, data on anorectal physiological parameters following it are scanty. METHODS: Consecutive patients with FED with CC diagnosed by abnormalities in at least two of the three tests (anorectal manometry, defecography, and balloon expulsion test [BET]) undergoing biofeedback (two sessions per day, 30 min each, for 2 weeks) during a 3-year period were analyzed...
February 18, 2017: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/28211254/egyptian-tale-from-india-application-of-whole-exome-sequencing-in-diagnosis-of-atypical-familial-mediterranean-fever
#4
Pulukool Sandhya, Shamsudheen Karuthedath Vellarikkal, Aswin Nair, Rowmika Ravi, John Mathew, Rijith Jayarajan, Anoop Kumar, Ankit Verma, Ambily Sivadas, Debashish Danda, Sridhar Sivasubbu, Vinod Scaria
Clinical diagnosis of autoinflammatory diseases requires a high degree of clinical suspicion and clinching molecular evidence to substantiate the diagnosis. This is more so in populations with low prevalence of these disorders. In this report, we describe the case of a young man from India with recurrent fever and persistent arthritis. The patient's forefathers were of Egyptian ancestry who practiced consanguinity. Molecular genetic analysis using whole-exome sequencing suggested the presence of variants c...
February 17, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28210439/effect-of-endoactivator-and-er-cr-ysgg-laser-activation-of-qmix-as-final-endodontic-irrigant-on-sealer-penetration-a-confocal-microscopic-study
#5
Sarika Chaudhry, Sudha Yadav, Sangeeta Talwar, Mahesh Verma
BACKGROUND: Through chemomechanical debridement of the root canal is a primary requisite for successful endodontic therapy. Thus the aim of this study was to evaluate the effects of using QmiX alone, QmiX with EndoActivator and QmiX with Er,Cr:YSGG laser for final irrigation on sealer penetration into the dentinal tubules. MATERIAL AND METHODS: 75 extracted human mandibular premolar teeth were treated with sodium hypochlorite (NaOCl) irrigation. The samples were divided into 5 groups according to the final irrigation solution used: (1) 17% EDTA and 2...
February 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28208996/stress-distribution-under-commercial-denture-liners-a-finite-element-and-clinical-analysis
#6
Rahul Shrivastava, Saurabh Chaturvedi, Ashok Kumar Verma, Mariyum Ali, Amrita Nagendra, Mudita Chaturvedi
INTRODUCTION: Previous studies have shown that 20-30% of denture users have been dissatisfied with their dentures. AIM: To evaluate the stress pattern under elastic and viscoelastic denture liners using 3-Dimensional Finite Element Analysis (FEA) and its clinical correlation using a questionnaire. MATERIALS AND METHODS: The study had both in-vitro and in-vivo phases. In in-vitro phase fabrication of a virtual parametric model of edentulous maxilla and dentures with overlying mucosa was made...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28208941/anti-mullerian-hormone-a-marker-of-ovarian-reserve-and-its-association-with-polycystic-ovarian-syndrome
#7
Anil Kumar Verma, Sarita Rajbhar, Jyoti Mishra, Mayank Gupta, Mratunjai Sharma, Geeta Deshmukh, Wahid Ali
INTRODUCTION: Anti-Mullerian Hormone (AMH) is a useful endocrine marker for assessing the ovarian reserve. AMH serum level reflects the number of follicles that have made the transition from the primordial pool into the growing follicle pool, and it is not controlled by gonadotropins. AIM: The present study was conducted to correlate serum AMH levels with Polycystic Ovarian Syndrome (PCOS) and type of treatment protocol. MATERIALS AND METHODS: Serum AMH levels were performed in the early follicular phase (on 2(nd) day of menstrual cycle) both in infertile females including PCOS and control women...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28208269/perspective-status-and-future-of-analytical-chemistry-in-india
#8
Krishna K Verma
Relative to many other areas in chemistry, analytical chemistry appears singularly lagging behind in India despite the commendable growth it had shown in the past both in teaching and research. Certain presumptions in policy making and current educational practices are believed to be the crux of the problem.
February 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28207947/association-and-expression-of-antigen-processing-gene-psmb8-coding-for-low-molecular-mass-protease-7-lmp7-with-vitiligo-in-north-india-case-control-study
#9
P Dani, N Patnaik, A Singh, A Jaiswal, B Agrawal, A A Kumar, S R Varkhande, A Sharma, U Vaish, P Ghosh, V K Sharma, P Sharma, G Verma, H K Kar, S Gupta, V T Natarajan, R S Gokhale, R Rani
BACKGROUND: Vitiligo is a multifactorial, autoimmune, depigmenting disorder of the skin where aberrant presentation of auto antigens may have a role to play. OBJECTIVES: To study the association of antigen processing genes, PSMB8 and PSMB9 with vitiligo. METHODS: 1320 vitiligo cases (1050 generalized and 270 localized) and 752 normal healthy controls were studied for PSMB9 exon 3 G/A SNP, PSMB8 exon 2 C/A SNP and PSMB8 Intron 6 G/T at 37360 site using PCR-RFLP...
February 16, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28207400/a-low-cost-adaptive-balance-training-platform-for-stroke-patients-a-usability-study
#10
Sunny Verma, Deepesh Kumar, Animesh Kumawat, Anirban Dutta, Uttama Lahiri
Stroke patients usually suffer from asymmetric posture due to hemi-paresis that can result in reduced postural controllability leading to a balance deficit. This deficit increases the risk of falls, which often makes them dependent on caregivers for community ambulation, thus deteriorating their quality of life. Conventional balance training involves rehabilitation exercises performed under physiotherapist's supervision where the scarcity of trained professionals as well as the cost of clinic-based rehabilitation programs can deter stroke survivors from undergoing regular balance training...
February 9, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28205644/bribery-games-on-inter-dependent-regular-networks
#11
Prateek Verma, Anjan K Nandi, Supratim Sengupta
We examine a scenario of social conflict that is manifest during an interaction between government servants providing a service and citizens who are legally entitled to the service, using evolutionary game-theory in structured populations characterized by an inter-dependent network. Bribe-demands by government servants during such transactions, called harassment bribes, constitute a widespread form of corruption in many countries. We investigate the effect of varying bribe demand made by corrupt officials and the cost of complaining incurred by harassed citizens, on the proliferation of corrupt strategies in the population...
February 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28203598/treatment-of-ulnar-collateral-ligament-tears-of-the-elbow-is-repair-a-viable-option
#12
Brandon J Erickson, Bernard R Bach, Nikhil N Verma, Charles A Bush-Joseph, Anthony A Romeo
BACKGROUND: Ulnar collateral ligament (UCL) tears have become common, and UCL reconstruction (UCLR) is currently the preferred surgical treatment method for treating UCL tears. PURPOSE/HYPOTHESIS: The purpose of this study was to review the literature surrounding UCL repair and determine the viability of new repair techniques for treatment of UCL tears. We hypothesized that UCL repair techniques will provide comparable results to UCLR for treatment of UCL tears...
January 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28202722/systemic-delivery-of-factor-ix-messenger-rna-for-protein-replacement-therapy
#13
Suvasini Ramaswamy, Nina Tonnu, Kiyoshi Tachikawa, Pattraranee Limphong, Jerel B Vega, Priya P Karmali, Pad Chivukula, Inder M Verma
Safe and efficient delivery of messenger RNAs for protein replacement therapies offers great promise but remains challenging. In this report, we demonstrate systemic, in vivo, nonviral mRNA delivery through lipid nanoparticles (LNPs) to treat a Factor IX (FIX)-deficient mouse model of hemophilia B. Delivery of human FIX (hFIX) mRNA encapsulated in our LUNAR LNPs results in a rapid pulse of FIX protein (within 4-6 h) that remains stable for up to 4-6 d and is therapeutically effective, like the recombinant human factor IX protein (rhFIX) that is the current standard of care...
February 15, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28202549/relationships-between-type-2-diabetes-neuropathy-and-microvascular-dysfunction-evidence-from-patients-with-cryptogenic-axonal-polyneuropathy
#14
Anna L Emanuel, Mariska D Nieuwenhoff, Erica S Klaassen, Ajay Verma, Mark H H Kramer, Rob Strijers, Alexander F J E Vrancken, Etto Eringa, Geert Jan Groeneveld, Erik H Serné
OBJECTIVE: This study investigated whether the relationship between neuropathy and microvascular dysfunction in patients with type 2 diabetes is independent of diabetes-related factors. For this purpose, we compared skin microvascular function in patients with type 2 diabetes with that of patients with cryptogenic axonal polyneuropathy (CAP), a polyneuropathy of unknown etiology. RESEARCH DESIGN AND METHODS: Cross-sectional information was collected from 16 healthy controls (HCs), 16 patients with CAP, 15 patients with type 2 diabetes with polyneuropathy (DPN), and 11 patients with type 2 diabetes without polyneuropathy...
February 15, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28198468/nanomechanical-effects-of-light-unveil-photons-momentum-in-medium
#15
Gopal Verma, Komal Chaudhary, Kamal P Singh
Precision measurement on momentum transfer between light and fluid interface has many implications including resolving the intriguing nature of photons momentum in a medium. For example, the existence of Abraham pressure of light under specific experimental configuration and the predictions of Chau-Amperian formalism of optical momentum for TE and TM polarizations remain untested. Here, we quantitatively and cleanly measure nanomehanical dynamics of water surface excited by radiation pressure of a laser beam...
February 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28198095/genetic-risk-models-influence-of-model-size-on-risk-estimates-and-precision
#16
Ying Shan, Gerard Tromp, Helena Kuivaniemi, Diane T Smelser, Shefali S Verma, Marylyn D Ritchie, James R Elmore, David J Carey, Yvette P Conley, Michael B Gorin, Daniel E Weeks
Disease risk estimation plays an important role in disease prevention. Many studies have found that the ability to predict risk improves as the number of risk single-nucleotide polymorphisms (SNPs) in the risk model increases. However, the width of the confidence interval of the risk estimate is often not considered in the evaluation of the risk model. Here, we explore how the risk and the confidence interval width change as more SNPs are added to the model in the order of decreasing effect size, using both simulated data and real data from studies of abdominal aortic aneurysms and age-related macular degeneration...
February 15, 2017: Genetic Epidemiology
https://www.readbyqxmd.com/read/28197946/alterations-in-the-skin-of-labeo-rohita-exposed-to-an-azo-dye-eriochrome-black-t-a-histopathological-and-enzyme-biochemical-investigation
#17
Ayan Srivastava, Neeraj Verma, Arup Mistri, Brijesh Ranjan, Ashwini Kumar Nigam, Usha Kumari, Swati Mittal, Ajay Kumar Mittal
Histopathological changes and alterations in the activity of certain metabolic and antioxidant enzymes were analyzed in the head skin of Labeo rohita, exposed to sublethal test concentrations of the azo dye, Eriochrome black T for 4 days, using 24 h renewal bioassay method. Hypertrophied epithelial cells, increased density of mucous goblet cells, and profuse mucous secretion at the surface were considered to protect the skin from toxic impact of the azo dye. Degenerative changes including vacuolization, shrinkage, decrease in dimension, and density of club cells with simultaneous release of their contents in the intercellular spaces were associated to plug them, preventing indiscriminate entry of foreign matter...
February 15, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28197924/sumoylation-as-an-integral-mechanism-in-bacterial-infection-and-disease-progression
#18
Chittur V Srikanth, Smriti Verma
Post translational modification pathways regulate fundamental processes of cells and thus govern vital functions. Among these, particularly the modification with Small Ubiquitin-like Modifiers (SUMO) is being recognized as a pathway crucial for cell homeostasis and health. Understandably, bacterial pathogens intervene with the SUMO pathway of the host for ensuring successful infection. Among the bacterial pathogens known to target host sumoylation varied points of intervention are utilized. Majority of them including Salmonella Typhimurium, Shigella flexneri and Listeria monocytogenes target the E2 conjugating enzyme Ubc9...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28196600/genome-editing-in-hpscs-reveals-gata6-haploinsufficiency-and-a-genetic-interaction-with-gata4-in-human-pancreatic-development
#19
Zhong-Dong Shi, Kihyun Lee, Dapeng Yang, Sadaf Amin, Nipun Verma, Qing V Li, Zengrong Zhu, Chew-Li Soh, Ritu Kumar, Todd Evans, Shuibing Chen, Danwei Huangfu
Human disease phenotypes associated with haploinsufficient gene requirements are often not recapitulated well in animal models. Here, we have investigated the association between human GATA6 haploinsufficiency and a wide range of clinical phenotypes that include neonatal and adult-onset diabetes using CRISPR (clustered regularly interspaced short palindromic repeat)/Cas9-mediated genome editing coupled with human pluripotent stem cell (hPSC) directed differentiation. We found that loss of one GATA6 allele specifically affects the differentiation of human pancreatic progenitors from the early PDX1+ stage to the more mature PDX1+NKX6...
February 8, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28196415/hierarchical-assembly-of-tough-bioelastomeric-egg-capsules-is-mediated-by-a-bundling-protein
#20
Jun Jie Loke, Akshita Kumar, Shawn Hoon, Chandra S Verma, Ali Miserez
Marine snail egg capsules are shock-absorbing bio-elastomers made from precursor "egg case proteins" (ECPs) that initially lack long-range order. During capsule formation, these proteins self-assemble into coiled-coil filaments that subsequently align into microscopic layers, a multi-scale process which is crucial to the capsules' shock-absorbing properties. In this study, we show that the self-assembly of ECPs into their functional capsule material is mediated by a bundling protein that facilitates the aggregation of coiled-coil building blocks and their gelation into a pre-final capsule prior to final stabilization...
February 14, 2017: Biomacromolecules
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