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https://www.readbyqxmd.com/read/29458074/subthalamic-nucleus-stimulation-dopaminergic-treatment-and-impulsivity-in-parkinson-s-disease
#1
Frédérique Fluchère, Borís Burle, Franck Vidal, Wery van den Wildenberg, Tatiana Witjas, Alexandre Eusebio, Jean-Philippe Azulay, Thierry Hasbroucq
BACKGROUND: Deep brain stimulation of the subthalamic nucleus (STN DBS) is known to increase response speed and lower response accuracy in Parkinson's disease (PD) patients. It has been proposed that this speed-accuracy tradeoff is due to enhanced sensitivity of the motor system to sensory information. An alternative possibility is that this effect is due to weakened suppressive processes. The two alternative interpretations can be tested by analyzing the electromyographic activity (EMG) of the response agonists when the patients perform conflict reaction time tasks...
February 16, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29458036/plasma-amyloid-levels-within-the-alzheimer-s-process-and-correlations-with-central-biomarkers
#2
Olivier Hanon, Jean-Sébastien Vidal, Sylvain Lehmann, Stéphanie Bombois, Bernadette Allinquant, Jean-Marc Tréluyer, Patrick Gelé, Christine Delmaire, Fredéric Blanc, Jean-François Mangin, Luc Buée, Jacques Touchon, Jacques Hugon, Bruno Vellas, Evelyne Galbrun, Athanase Benetos, Gilles Berrut, Elèna Paillaud, David Wallon, Giovanni Castelnovo, Lisette Volpe-Gillot, Marc Paccalin, Philippe-Henri Robert, Olivier Godefroy, Thierry Dantoine, Vincent Camus, Joël Belmin, Pierre Vandel, Jean-Luc Novella, Emmanuelle Duron, Anne-Sophie Rigaud, Suzanna Schraen-Maschke, Audrey Gabelle
BACKGROUNDS: Diagnostic relevance of plasma amyloid β (Aβ) for Alzheimer's disease (AD) process yields conflicting results. OBJECTIVES: To assess plasma levels of Aβ42 and Aβ40 in amnestic mild cognitive impairment (MCI), nonamnestic MCI, and AD patients and to investigate relationships between peripheral and central biomarkers. METHODS: One thousand forty participants (417 amnestic MCI, 122 nonamnestic MCI, and 501 AD) from the Biomarker of AmyLoïd pepTide and AlZheimer's diseAse Risk multicenter prospective study with cognition, plasma, cerebrospinal fluid (CSF), and magnetic resonance imaging assessments were included...
February 16, 2018: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29456754/management-of-osteonecrosis-of-the-femoral-head-in-children-with-sickle-cell-disease-results-of-conservative-and-operative-treatments-at-skeletal-maturity
#3
C Mallet, A Abitan, C Vidal, L Holvoet, K Mazda, A-L Simon, B Ilharreborde
Purpose: Sickle cell disease (SCD) is the most common cause of femoral head osteonecrosis (ONFH) during childhood with an overall prevalence of 10%. In children, spontaneous revascularization can occur, as in Legg-Calve-Perthes disease. Consequently, the aim of treatment is to restore proper hip containment to prevent joint arthritis. This is the first study reporting long-term results at skeletal maturity of non-operative and surgical treatments for ONFH in SCD children. Methods: All children with ONFH due to SCD were retrospectively reviewed...
February 1, 2018: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/29456750/paediatric-tibial-shaft-fractures-treated-by-open-reduction-and-stabilization-with-monolateral-external-fixation
#4
A-L Simon, N Apostolou, C Vidal, E Ferrero, K Mazda, B Ilharreborde
Purpose: Elastic stable intramedullary nailing is increasingly used for surgical treatment of tibial shaft fractures, but frequently requires immobilization and delayed full weight-bearing. Therefore, external fixation remains interesting. The aim was to report clinico-radiological outcomes of monolateral external fixation for displaced and unstable tibial shaft fractures in children. Methods: All tibial fractures consecutively treated by monolateral external fixation between 2008 and 2013 were followed...
February 1, 2018: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/29454498/-maintenance-of-exclusive-breastfeeding-after-three-months-postpartum-an-experience-in-a-health-department-of-a-valencian-community
#5
Rafael Vila-Candel, Francisco J Soriano-Vidal, Mayte Murillo-Llorente, Marcelino Pérez-Bermejo, Enrique Castro-Sánchez
AIMS: To investigate the prevalence of EBF at 3-months postpartum, and the early factors for discontinuation. DESIGN: Observational, retrospective study. LOCATION: Health department of La Ribera, Valencia, Spain. PARTICIPANTS: Newborns between December 2012 to January 2017. METHODS: Pregnant women were interviewed at postpartum and at 3 months regarding variables associated with breastfeeding initiation and continuation, matched with socio-demographic and obstetric-neonatal information...
February 14, 2018: Atencion Primaria
https://www.readbyqxmd.com/read/29452589/does-additional-support-provided-through-e-mail-or-sms-in-a-web-based-social-marketing-program-improve-children-s-food-consumption-a-randomized-controlled-trial
#6
Natalie Rangelov, Sara Della Bella, Pedro Marques-Vidal, L Suzanne Suggs
BACKGROUND: The FAN Social Marketing program was developed to improve dietary and physical activity habits of families with children in Ticino, Switzerland. The aim of this study was to examine if the effects of the program on children's food intake differed by intervention group. METHODS: Effects of the FAN program were tested through a Randomized Controlled Trial. The program lasted 8 weeks, during which participants received tailored communication about nutrition and physical activity...
February 16, 2018: Nutrition Journal
https://www.readbyqxmd.com/read/29452342/neurofilament-light-chain-and-oligoclonal-bands-are-prognostic-biomarkers-in-radiologically-isolated-syndrome
#7
Clara Matute-Blanch, Luisa M Villar, José C Álvarez-Cermeño, Konrad Rejdak, Evgeniy Evdoshenko, Gleb Makshakov, Vladimir Nazarov, Sergey Lapin, Luciana Midaglia, Angela Vidal-Jordana, Jelena Drulovic, Antonio García-Merino, Antonio J Sánchez-López, Eva Havrdova, Albert Saiz, Sara Llufriu, Roberto Alvarez-Lafuente, Ina Schroeder, Uwe K Zettl, Daniela Galimberti, Lluís Ramió-Torrentà, René Robles, Ester Quintana, Harald Hegen, Florian Deisenhammer, Jordi Río, Mar Tintoré, Alex Sánchez, Xavier Montalban, Manuel Comabella
The prognostic role of cerebrospinal fluid molecular biomarkers determined in early pathogenic stages of multiple sclerosis has yet to be defined. In the present study, we aimed to investigate the prognostic value of chitinase 3 like 1 (CHI3L1), neurofilament light chain, and oligoclonal bands for conversion to clinically isolated syndrome and to multiple sclerosis in 75 patients with radiologically isolated syndrome. Cerebrospinal fluid levels of CHI3L1 and neurofilament light chain were measured by enzyme-linked immunosorbent assay...
February 14, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29452106/nerve-fibre-layer-degeneration-and-retinal-ganglion-cell-loss-long-term-after-optic-nerve-crush-or-transection-in-adult-mice
#8
M C Sánchez-Migallón, F J Valiente-Soriano, M Salinas-Navarro, F M Nadal-Nicolás, M Jiménez-López, M Vidal-Sanz, M Agudo-Barriuso
We have investigated the long term effects of two different models of unilateral optic nerve (ON) lesion on retinal ganglion cells (RGCs) and their axons, in the injured and contralateral retinas of adult albino mice. Intact animals were used as controls. The left ON was intraorbitally crushed or transected at 0.5 mm from the optic disk and both retinas were analyzed at 2, 3, 5, 7, 14, 30, 45 or 90 days after injury. RGCs were immunoidentified with anti-Brn3a, and their axons with anti-highly phosphorylated axonal neurofilament subunit H (pNFH)...
February 13, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29451598/performance-of-cryptococcal-antigen-lateral-flow-assay-in-serum-cerebrospinal-fluid-whole-blood-and-urine-in-hiv-infected-patients-with-culture-proven-cryptococcal-meningitis-admitted-at-a-brazilian-referral-center
#9
José E Vidal, Carolina Toniolo, Adriana Paulino, Arnaldo L Colombo, Marilena Dos Anjos Martins, Cristina da Silva Meira, Renata Guise Soares Azevedo, Vera Lucia Pereira-Chioccola, Hélio Rodrigues Gomes, Marcia Dos Santos Lazera, Augusto C Penalva de Oliveira, David R Boulware
Cryptococcal meningitis is the most common cause of opportunistic meningitis in HIV-infected patients in Brazil and causes unacceptable high mortality rates. In this study, HIV-infected patients with a first episode of culture-proven cryptococcal meningitis in cerebrospinal fluid (CSF) were prospectively included in order to evaluate sensitivity of cryptococcal antigen (CrAg) lateral flow assay (LFA) in serum, CSF, whole blood (fingerstick), and fresh urine. In addition, HIV-infected patients with other neurological confirmed diseases were included in order to evaluate the specificity of CrAg LFA in serum...
2018: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/29451279/nitrogen-doped-nanohoops-as-promising-co-2-capturing-devices
#10
Ángel Vidal Vidal, Carlos Silva López, Olalla Nieto Faza
The impact of climate change in the face of steady or increasing emissions has made the capture and storage of CO 2 a priority issue. Supramolecular chemistry is one of the tools that can be used for this task, due to the possibility of tuning intermolecular interactions for the capture of this gas in a selective and efficient way. In this context, this work presents a novel approach for the capture of CO 2 based on n-cycloparaphenylenes ([n]-CPPs) doped with nitrogen atoms. This is the first time that the potential of these structures for the capture of polluting gases has been evaluated...
February 16, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29449287/global-influenza-hospital-based-surveillance-network-gihsn-results-of-surveillance-of-influenza-and-other-respiratory-viruses-in-hospitalised-patients-in-brazil-2015
#11
Sonia M Raboni, Fernanda E A Moura, Braulia C Caetano, Valéria M Avanzi, Luciane A Pereira, Meri B Nogueira, Luine R Vidal, Isabel C F Tavares, Florence K Pradel, Valentina S Picot, Joan Puig-Barbera, Marilda M Siqueira
BACKGROUND: Influenza-like illness occurs annually worldwide, with peak timing and severity varying seasonally, resulting in significant annual mortality. OBJECTIVES: There were three objectives: (1) to describe the epidemiological and clinical features of hospitalised patients with severe acute respiratory infection caused by influenza and other respiratory viruses (ORVs); (2) to report the influenza seasonality in the region and (3) to correlate findings of influenza circulation and immunisation time in Brazil...
February 15, 2018: BMJ Open
https://www.readbyqxmd.com/read/29448955/analysis-of-the-genetic-diversity-and-mrna-expression-level-in-porcine-reproductive-and-respiratory-syndrome-virus-vaccinated-pigs-that-developed-short-or-long-viremias-after-challenge
#12
Martí Cortey, Gaston Arocena, Tahar Ait-Ali, Anna Vidal, Yanli Li, Gerard Martín-Valls, Alison D Wilson, Allan L Archibald, Enric Mateu, Laila Darwich
Porcine reproductive and respiratory syndrome virus (PRRSv) infection alters the host's cellular and humoral immune response. Immunity against PRRSv is multigenic and vary between individuals. The aim of the present study was to compare several genes that encode for molecules involved in the immune response between two groups of vaccinated pigs that experienced short or long viremic periods after PRRSv challenge. These analyses include the sequencing of four SLA Class I, two Class II allele groups, and CD163, plus the analysis by quantitative realtime qRT-PCR of the constitutive expression of TLR2, TLR3, TLR4, TLR7, TLR8 and TLR9 mRNA and other molecules in peripheral blood mononuclear cells...
February 15, 2018: Veterinary Research
https://www.readbyqxmd.com/read/29447933/ultrasound-guided-percutaneous-electrolysis-a-new-therapeutic-option-for-mammary-fistulas
#13
Juan D Berná-Serna, José A García-Vidal, Pilar Escolar-Reina, Juan D Berná-Mestre
Mammary fistula (MF) is a recurrent condition characterised by the draining of abscesses around the areola. The best management for MF remains challenging. Moreover, the main problem is the high recurrence rate of this disease. MF is considered a chronic process. The percutaneous electrolysis (PE) technique involves the application of a galvanic current with an ultrasound-guided needle to induce ablation and repair of the affected tissue. Good results have been obtained with PE in chronic tendinopathies. Below we present a hypothesis that PE may be a new therapeutic option for MF...
March 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29447772/the-optimal-anti-coagulation-for-enhanced-risk-patients-post-catheter-ablation-for-atrial-fibrillation-ocean-trial
#14
Atul Verma, Andrew C T Ha, Paulus Kirchhof, Gerhard Hindricks, Jeff S Healey, Michael D Hill, Mukul Sharma, D George Wyse, Jean Champagne, Vidal Essebag, George Wells, Dhiraj Gupta, Hein Heidbuchel, Prashanthan Sanders, David H Birnie
BACKGROUND: The optimal long-term antithrombotic regimen for patients after successful catheter-based atrial fibrillation (AF) ablation is not well defined. Presently, practice variation exists, and the benefits of oral anticoagulation over antiplatelet therapy across the entire spectrum of stroke risk profile remain undefined in the postablation population. To date, there are no randomized trials to inform clinicians on this therapeutic question. OBJECTIVE: The objective was to assess whether rivaroxaban is superior to acetylsalicylic acid (ASA) in reducing the risk of clinically overt stroke, systemic embolism, or covert stroke among patients without apparent recurrent atrial arrhythmias for at least 1 year after their most recent AF ablation procedure...
March 2018: American Heart Journal
https://www.readbyqxmd.com/read/29445458/stevens-johnson-syndrome-toxic-epidermal-necrolysis-associated-with-zonisamide
#15
Karina L Vivar, Kimberly Mancl, Lucia Seminario-Vidal
This report highlights zonisamide as a potential cause of serious cutaneous reactions as well as its cross-reactivity with other sulfonamides. Here, we present a case of SJS-TEN due to zonisamide, which was effectively treated with IVIg. Subsequently, the patient was transitioned to levetiracetam for seizure control.
February 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29445177/validating-a-breast-cancer-score-in-spanish-women-the-mcc-spain-study
#16
Trinidad Dierssen-Sotos, Inés Gómez-Acebo, Camilo Palazuelos, Pablo Fernández-Navarro, Jone M Altzibar, Carmen González-Donquiles, Eva Ardanaz, Mariona Bustamante, Jessica Alonso-Molero, Carmen Vidal, Juan Bayo-Calero, Adonina Tardón, Dolores Salas, Rafael Marcos-Gragera, Víctor Moreno, Paz Rodriguez-Cundin, Gemma Castaño Vinyals, María Ederra, Laura Vilorio-Marqués, Pilar Amiano, Beatriz Pérez-Gómez, Nuria Aragonés, Manolis Kogevinas, Marina Pollán, Javier Llorca
A breast-risk score, published in 2016, was developed in white-American women using 92 genetic variants (GRS92), modifiable and non-modifiable risk factors. With the aim of validating the score in the Spanish population, 1,732 breast cancer cases and 1,910 controls were studied. The GRS92, modifiable and non-modifiable risk factor scores were estimated via logistic regression. SNPs without available genotyping were simulated as in the aforementioned 2016 study. The full model score was obtained by combining GRS92, modifiable and non-modifiable risk factor scores...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29444840/intestinal-%C3%AE-glycosidase-transcriptional-responses-during-development-and-diet-adjustment-in-altricial-birds
#17
Claudia Gatica-Sosa, Pawel Brzęk, Melisa Magallanes, William H Karasov, Enrique Caviedes-Vidal
We describe developmental changes in maltasic activity and its mRNA through adulthood, and in response to increase in dietary starch. We studied house sparrows (HOSP; Passer domesticus L.), which undergo a natural switch from insects to starch-containing seed diet during development, and zebra finch (ZEBF; Taeniopygia guttata V.), which have a relatively fixed starchy-seed diet during development. In ZEBF, in whom maltasic activity increased with age but not with dietary starch, α -glycosidase (AG) mRNA was not affected by either age or dietary starch level...
February 14, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29443976/how-many-human-proteoforms-are-there
#18
Ruedi Aebersold, Jeffrey N Agar, I Jonathan Amster, Mark S Baker, Carolyn R Bertozzi, Emily S Boja, Catherine E Costello, Benjamin F Cravatt, Catherine Fenselau, Benjamin A Garcia, Ying Ge, Jeremy Gunawardena, Ronald C Hendrickson, Paul J Hergenrother, Christian G Huber, Alexander R Ivanov, Ole N Jensen, Michael C Jewett, Neil L Kelleher, Laura L Kiessling, Nevan J Krogan, Martin R Larsen, Joseph A Loo, Rachel R Ogorzalek Loo, Emma Lundberg, Michael J MacCoss, Parag Mallick, Vamsi K Mootha, Milan Mrksich, Tom W Muir, Steven M Patrie, James J Pesavento, Sharon J Pitteri, Henry Rodriguez, Alan Saghatelian, Wendy Sandoval, Hartmut Schlüter, Salvatore Sechi, Sarah A Slavoff, Lloyd M Smith, Michael P Snyder, Paul M Thomas, Mathias Uhlén, Jennifer E Van Eyk, Marc Vidal, David R Walt, Forest M White, Evan R Williams, Therese Wohlschlager, Vicki H Wysocki, Nathan A Yates, Nicolas L Young, Bing Zhang
Despite decades of accumulated knowledge about proteins and their post-translational modifications (PTMs), numerous questions remain regarding their molecular composition and biological function. One of the most fundamental queries is the extent to which the combinations of DNA-, RNA- and PTM-level variations explode the complexity of the human proteome. Here, we outline what we know from current databases and measurement strategies including mass spectrometry-based proteomics. In doing so, we examine prevailing notions about the number of modifications displayed on human proteins and how they combine to generate the protein diversity underlying health and disease...
February 14, 2018: Nature Chemical Biology
https://www.readbyqxmd.com/read/29441435/impacts-of-hydrous-manganese-oxide-on-the-retention-and-lability-of-dissolved-organic-matter
#19
Jason W Stuckey, Christopher Goodwin, Jian Wang, Louis A Kaplan, Prian Vidal-Esquivel, Thomas P Beebe, Donald L Sparks
Minerals constitute a primary ecosystem control on organic C decomposition in soils, and therefore on greenhouse gas fluxes to the atmosphere. Secondary minerals, in particular, Fe and Al (oxyhydr)oxides-collectively referred to as "oxides" hereafter-are prominent protectors of organic C against microbial decomposition through sorption and complexation reactions. However, the impacts of Mn oxides on organic C retention and lability in soils are poorly understood. Here we show that hydrous Mn oxide (HMO), a poorly crystalline δ-MnO2, has a greater maximum sorption capacity for dissolved organic matter (DOM) derived from a deciduous forest composite Oi, Oe, and Oahorizon leachate ("O horizon leachate" hereafter) than does goethite under acidic (pH 5) conditions...
February 13, 2018: Geochemical Transactions
https://www.readbyqxmd.com/read/29438313/polysiloxane-polystyrene-thermo-responsive-and-self-healing-polymer-network-via-lewis-acid-lewis-base-pair-formation
#20
Fernando Vidal, Huina Lin, Cecilia Morales, Frieder Jäkle
The use of thermo-reversible Lewis Pair (LP) interactions in the formation of transient polymer networks is still greatly underexplored. In this work, we describe the synthesis and characterization of polydimethylsiloxane/polystyrene (PDMS/PS) blends that form dynamic Lewis acid-Lewis base adducts resulting in reversible crosslinks. Linear PS containing 10 mol % of di-2-thienylboryl pendant groups randomly distributed was obtained in a two-step one-pot functionalization reaction from silyl-functionalized PS, while ditelechelic PDMS with pyridyl groups at the chain-termini was directly obtained via thiol-ene "click" chemistry from commercially available vinyl-terminated PDMS...
February 13, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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