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Adrien Bouglé, Camille Bombled, Dimitri Margetis, Guillaume Lebreton, Charles Vidal, Marine Coroir, David Hajage, Julien Amour
INTRODUCTION: Ventilator-associated pneumonia (VAP) is frequent in Intensive Care Unit (ICU) patients. In the specific case of patients treated with Veno-Arterial Extracorporeal Membrane Oxygenation Support (VA-ECMO), VAP treatment failures (VAP-TF) have been incompletely investigated. METHODS: To investigate the risk factors of treatment failure (VAP-TF) in a large cohort of ICU patients treated with VA-ECMO, we conducted a retrospective study in a Surgical ICU about patients assisted with VA-ECMO between January 1, 2013, and December 31, 2014...
2018: PloS One
Lukas Landler, Simon Nimpf, Tobias Hochstoeger, Gregory C Nordmann, Artemis Papadaki-Anastasopoulou, David A Keays
A diverse array of species on the planet employ the Earth's magnetic field as a navigational aid. As the majority of these animals are migratory, their utility to interrogate the molecular and cellular basis of the magnetic sense is limited. Vidal-Gadea and colleagues recently argued that the worm Caenorhabditis elegans possesses a magnetic sense that guides their vertical movement in soil. In making this claim, they relied on three different behavioral assays that involved magnetic stimuli. Here, we set out to replicate their results employing blinded protocols and double wrapped coils that control for heat generation...
April 13, 2018: ELife
Andres Vidal-Gadea, Chance Bainbridge, Ben Clites, Bridgitte E Palacios, Layla Bakhtiari, Vernita Gordon, Jonathan Pierce-Shimomura
Many animals can orient using the earth's magnetic field. In a recent study, we performed three distinct behavioral assays providing evidence that the nematode Caenorhabditis elegans orients to earth-strength magnetic fields (<xref ref-type="bibr" rid="bib28">Vidal-Gadea et al., 2015</xref>). A new study by Landler et al. suggests that C. elegans does not orient to magnetic fields (<xref ref-type="bibr" rid="bib10">Landler et al., 2018</xref>)...
April 13, 2018: ELife
M Hennes, V Schuler, X Weng, J Buchwald, D Demaille, Y Zheng, F Vidal
We employ kinetic Monte-Carlo simulations to study the growth process of metal-oxide nanocomposites obtained via sequential pulsed laser deposition. Using Ni-SrTiO3 (Ni-STO) as a model system, we reduce the complexity of the computational problem by choosing a coarse-grained approach mapping Sr, Ti and O atoms onto a single effective STO pseudo-atom species. With this ansatz, we scrutinize the kinetics of the sequential synthesis process, governed by alternating deposition and relaxation steps, and analyze the self-organization propensity of Ni atoms into straight vertically aligned nanowires embedded in the surrounding STO matrix...
April 13, 2018: Nanoscale
Roberta Olmo Pinheiro, Veronica Schmitz, Bruno Jorge de Andrade Silva, André Alves Dias, Beatriz Junqueira de Souza, Mayara Garcia de Mattos Barbosa, Danuza de Almeida Esquenazi, Maria Cristina Vidal Pessolani, Euzenir Nunes Sarno
Leprosy is an infectious disease that may present different clinical forms depending on host immune response to Mycobacterium leprae . Several studies have clarified the role of various T cell populations in leprosy; however, recent evidences suggest that local innate immune mechanisms are key determinants in driving the disease to its different clinical manifestations. Leprosy is an ideal model to study the immunoregulatory role of innate immune molecules and its interaction with nervous system, which can affect homeostasis and contribute to the development of inflammatory episodes during the course of the disease...
2018: Frontiers in Immunology
Camilo Partezani Helito, Paulo Victor Partezani Helito, Renata Vidal Leão, Isabel Curcio Felix Louza, Marcelo Bordalo-Rodrigues, Giovanni Guido Cerri
OBJECTIVE: To characterize the anterolateral ligament (ALL) in normal knees of pediatric patients by magnetic resonance imaging (MRI) and to establish the age at which it is possible to visualize its presence and whether there are differences between male and female populations. MATERIALS AND METHODS: MRI scans of patients younger than 18 years were retrospectively evaluated. The exams were performed in 1.5-T scanners. The ALL was characterized dichotomously as visualized or not visualized based on the assessment criteria of this structure in adult patients...
April 7, 2018: Skeletal Radiology
Rosalía López-Ruiz, Roberto Romero-González, José Luis Martínez Vidal, Antonia Garrido Frenich
A degradation study of quizalofop-p and its commercial products (quizalofop-p-ethyl, quizalofop-p-tefuryl and propaquizafop) in water samples has been performed using ultra high-performance liquid chromatography coupled to Orbitrap mass spectrometry (UHPLC-Orbitrap-MS). CHHQ (dihydroxychloroquinoxalin), CHQ (6-chloroquinoxalin-2-ol) and PPA ((R)-2-(4-hydroxyphenoxy)propionicacid) were the main metabolites of this active substance (quizalofop-p) in water. The degradation of the parent compound has been monitored in distilled water...
April 5, 2018: Ecotoxicology and Environmental Safety
Guillaume Coutance, Lucas Van Aelst, Guillaume Hékimian, Charles Vidal, Philippe Rouvier, Samir Saheb, Chantal Gautreau, Pascal Leprince, Shaida Varnous
BACKGROUND: Data are scarce on the prognosis of heart allograft antibody-mediated rejection (AMR) with cardiogenic shock (CS). METHODS: We performed a retrospective, single center, observational study. We included patients with biopsy proven AMR and CS. We aimed to analyze the characteristics, treatment and prognosis of patients treated for CS due to AMR. Patients alive after AMR were followed to analyze recurrences of AMR, graft function and cardiac allograft vasculopathy (CAV)...
April 7, 2018: Clinical Transplantation
Jorge Vidal, Cesar Huiliñir, Rocío Santander, Javier Silva-Agredo, Ricardo A Torres-Palma, Ricardo Salazar
The elimination of the antibiotic Nafcillin (NAF), which is usually used in hospitals and veterinary clinics around the world, was assessed through a combination of three advanced electrochemical oxidation processes followed by anaerobic digestion process. In the first stage different electrochemical advanced oxidation processes (EAOPs) were used: electro-oxidation with hydrogen peroxide (EO-H2 O2 ), electro-Fenton (EF) and Photo electro-Fenton (PEF). After PEF, almost complete and highly efficient degradation and elimination of NAF was achieved, with the concomitant elimination of the associated antimicrobial activity...
May 15, 2018: Science of the Total Environment
Diego García-Ayuso, Johnny Di Pierdomenico, Wahiba Hadj-Said, Mélanie Marie, Marta Agudo-Barriuso, Manuel Vidal-Sanz, Serge Picaud, María P Villegas-Pérez
Purpose: To examine if light exposure exacerbates retinal neuronal loss induced by taurine depletion. Methods: Albino rats received β-alanine in the drinking water to induce taurine depletion. One month later, half of the animals were exposed to white light (3000 lux) continuously for 48 hours and the rest remained in normal environmental conditions. A control group of animals nontreated with β-alanine also was prepared, and half of them were exposed to light using the same protocol...
March 1, 2018: Investigative Ophthalmology & Visual Science
Verónica Vidal, Scott Robertson, Laura DeThorne
Purpose: The present clinical focus article describes and illustrates 3 key elements of a supports-based approach to enhancing friendship with autistic students. Method: In comparison to the predominant skills-based approach, we highlight 3 key elements of a supports-based approach to social interaction for autistic children and youth. We then offer descriptive details of the activity-based music program as an illustrative example of a program that integrated all 3 elements of a supports-based approach...
April 5, 2018: American Journal of Speech-language Pathology
Marcela Fu, Noémie Travier, Juan Carlos Martín-Sánchez, Jose M Martínez-Sánchez, Carmen Vidal, Montse Garcia
BACKGROUND: There are two main types of strategies to identify target population for lung cancer screening: 1) strategies based on age and cumulative smoking criteria, 2) risk prediction models allowing the calculation of an individual risk. The objective of this study was to compare different strategies to identify the proportion of the Spanish population at high risk of developing lung cancer, susceptible to be included in a lung cancer screening programme. METHODS: Cross-sectional study...
2018: PloS One
Marcos Quevedo-Diaz, Adrià Tauste Campo, Manel Vila-Vidal, Alessandro Principe, Miguel Ley, Rodrigo Rocamora
We report a patient presenting drug-resistant, non-dominant temporal lobe epilepsy with ictal spitting and prosopometamorphopsia, both extremely rare semiologies. Second-phase pre-surgical monitoring was performed using SEEG due to lesion-negative imaging and the rare semiology. The seizure onset zone was delimited to the right anterior hippocampus and the temporobasal cortex, with the propagation zone within the entorhinal cortex. Interestingly, direct electrical stimulation to the entorhinal cortex, which was reproduced in a number of trials, evoked spitting without leading to seizures or post-discharges...
April 5, 2018: Epileptic Disorders: International Epilepsy Journal with Videotape
Matthew S Holden, Yulong Zhao, Claire Haegelen, Caroline Essert, Sara Fernandez-Vidal, Eric Bardinet, Tamas Ungi, Gabor Fichtinger, Pierre Jannin
OBJECTIVE: Deep brain stimulation (DBS) is an increasingly common treatment for neurodegenerative diseases. Neurosurgeons must have thorough procedural, anatomical, and functional knowledge to plan electrode trajectories and thus ensure treatment efficacy and patient safety. Developing this knowledge requires extensive training. We propose a training approach with objective assessment of neurosurgeon proficiency in DBS planning. METHODS: To assess proficiency, we propose analyzing both the viability of the planned trajectory and the manner in which the operator arrived at the trajectory...
April 4, 2018: International Journal of Computer Assisted Radiology and Surgery
Bernardo Faria Ramos, Fábio de Rezende Pinna, Silvia Vidal Campos, José Eduardo Afonso Júnior, Ricardo Henrique de Oliveira Braga Teixeira, Rafael Medeiros Carraro, Richard Louis Voegels
Introduction  The association between sinus and lung diseases is well known. However, there are scarce studies regarding the effects of sinus surgery on pulmonary function in lung transplant recipients. The present study describes our experience with sinus surgery in lung transplant recipients with chronic rhinosinusitis. Objectives  To assess the impact of sinus surgery for chronic rhinosinusitis on pulmonary function and on inpatient hospitalization days due to lower respiratory tract infection in lung transplant recipients...
April 2018: International Archives of Otorhinolaryngology
Josep Maria Piulats, August Vidal, Francisco J García-Rodríguez, Clara Muñoz, Marga Nadal, Catia Moutinho, Maria Martínez-Iniesta, Josefina Mora, Agnes Figueras, Elisabet Guinó, Laura Padullés, Àlvaro Aytés, David G Mollevi, Sara Puertas, Carmen Martínez-Fernández, Wilmar Castillo, Merce Juliachs, Victor Moreno, Purificacion Muñoz, Milica Stefanovic, Miguel Angel Pujana, Enric Condom, Manel Esteller, Josep R Germà-LLuch, Gabriel Capella, Lourdes Farré, Albert Morales, Francesc Viñals, Xavier Garcia Del Muro, Julián Cerón, Alberto Villanueva
PURPOSE: To investigate the genetic basis of cisplatin resistance. Efficacy of cisplatin chemotherapy in the treatment of distinct malignancies is often hampered by intrinsic/ acquired drug resistance of tumors. EXPERIMENTAL DESIGN: We produced 14 orthoxenograft transplanting human nonseminomatous (NSE) testicular germ cell tumors (TGCTs) to mice, keeping the primary tumor features (genotype, phenotype and sensitivity to cisplatin). Chromosomal and genetic alterations were evaluated in matched cisplatin-sensitive and their counterpart orthoxenografts that developed resistance to cisplatin in vivo...
April 4, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Matthew T Bennett, Nathan Leader, John Sapp, Ratika Parkash, Martin Gardner, Jeffrey S Healey, Bernard Thibault, Larry Sterns, Vidal Essebag, David Birnie, Soori Sivakumaran, Pablo Nery, Jason G Andrade, Andrew D Krahn, Anthony Tang
BACKGROUND: Implantable cardioverter defibrillator arrhythmia discrimination algorithms often are unable to discriminate ventricular from supraventricular arrhythmias. We sought to evaluate whether the response to antitachycardia pacing (ATP) in patients with an implantable cardioverter defibrillator could further discriminate ventricular from supraventricular arrhythmias in patients receiving ATP. METHODS AND RESULTS: All episodes of ventricular or supraventricular tachycardia where ATP was delivered in patients enrolled in RAFT (Cardiac-Resynchronization Therapy for Mild-to-Moderate Heart Failure Trial) were included...
April 2018: Circulation. Arrhythmia and Electrophysiology
Ana C Vidal, Paula Banca, Augusto G Pascoal, Gustavo Cordeiro, João Sargento-Freitas, Ana Gouveia, Miguel Castelo-Branco
Background Understanding of interhemispheric interactions in stroke patients during motor control is an important clinical neuroscience quest that may provide important clues for neurorehabilitation. In stroke patients bilateral overactivation in both hemispheres has been interpreted as a poor prognostic indicator of functional recovery. In contrast, ipsilesional patterns have been linked with better motor outcomes. Aim We investigated the pathophysiology of hemispheric interactions during limb movement without and with contralateral restraint, to mimic the effects of constraint-induced movement therapy...
January 1, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
Cédric Gubelmann, Raphael Heinzer, José Haba-Rubio, Peter Vollenweider, Pedro Marques-Vidal
Study objectives: To evaluate the association of objective physical activity (PA) and sedentary behaviour (SB) with sleep duration and quality. Methods: Cross-sectional study including 2649 adults (53.5% women, 45-86 years) from the general population. Proportions of time spent in PA and SB were measured using 14-day accelerometry. Low PA and high SB status were defined as the lowest and highest tertile of each behaviour. 'Inactive', 'Weekend warrior' and 'Regularly active' weekly patterns were also defined...
March 30, 2018: Sleep
Mireia Jané, Maria José Vidal, Neus Camps, Magda Campins, Ana Martínez, Joan Balcells, Maria Teresa Martin-Gomez, Gloria Bassets, Silvia Herrera-León, Anton Foguet, Mar Maresma, Nuria Follia, Sonia Uriona, Tomàs Pumarola
In May 2015, following a 30-year diphtheria-free interval in Catalonia, an unvaccinated 6-year-old child was diagnosed with diphtheria caused by toxigenic Corynebacterium diphtheriae . After a difficult search for equine-derived diphtheria antitoxin (DAT), the child received the DAT 4 days later but died at the end of June. Two hundred and seventeen contacts were identified in relation to the index case, and their vaccination statuses were analysed, updated and completed. Of these, 140 contacts underwent physical examination and throat swabs were taken from them for analysis...
March 2018: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
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