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https://www.readbyqxmd.com/read/27855512/2016-white-paper-on-recent-issues-in-bioanalysis-focus-on-biomarker-assay-validation-bav-part-3-lba-biomarkers-and-immunogenicity
#1
Susan Richards, Lakshmi Amaravadi, Renuka Pillutla, Herbert Birnboeck, Albert Torri, Kyra J Cowan, Apollon Papadimitriou, Fabio Garofolo, Christina Satterwhite, Steven Piccoli, Bonnie Wu, Corinna Krinos-Fiorotti, John Allinson, Flora Berisha, Laurent Cocea, Stephanie Croft, Stephanie Fraser, Fabrizio Galliccia, Boris Gorovits, Swati Gupta, Vinita Gupta, Sam Haidar, Charles Hottenstein, Akiko Ishii-Watabe, Darshana Jani, John Kadavil, John Kamerud, Daniel Kramer, Virginia Litwin, Gustavo Mendes Lima Santos, Robert Nelson, Yan Ni, João Pedras-Vasconcelos, Yongchang Qiu, Paul Rhyne, Afshin Safavi, Yoshiro Saito, Natasha Savoie, Kara Scheibner, Eginhard Schick, Patricia Y Siguenza, John Smeraglia, Roland F Staack, Meena Subramanyam, Giane Sumner, Theingi Thway, David Uhlinger, Martin Ullmann, Alessandra Vitaliti, Jan Welink, Chan C Whiting, Li Xue, Rong Zeng
The 2016 10th Workshop on Recent Issues in Bioanalysis (10th WRIB) took place in Orlando, Florida with participation of close to 700 professionals from pharmaceutical/biopharmaceutical companies, biotechnology companies, contract research organizations, and regulatory agencies worldwide. WRIB was once again a weeklong event - A Full Immersion Week of Bioanalysis for PK, Biomarkers and Immunogenicity. As usual, it is specifically designed to facilitate sharing, reviewing, discussing and agreeing on approaches to address the most current issues of interest including both small and large molecules involving LCMS, hybrid LBA/LCMS, and LBA approaches, with the focus on PK, biomarkers and immunogenicity...
December 2016: Bioanalysis
https://www.readbyqxmd.com/read/27855509/2016-white-paper-on-recent-issues-in-bioanalysis-focus-on-biomarker-assay-validation-bav-part-2-hybrid-lba-lcms-and-input-from-regulatory-agencies
#2
An Song, Anita Lee, Fabio Garofolo, Surinder Kaur, Jeff Duggan, Christopher Evans, Joe Palandra, Lorella Di Donato, Keyang Xu, Ronald Bauer, Mark Bustard, Linzhi Chen, Laurent Cocea, Stephanie Croft, Fabrizio Galliccia, Sam Haidar, Nicola Hughes, Akiko Ishii-Watabe, Rafiqul Islam, Barry Jones, John Kadavil, Carsten Krantz, Gustavo Mendes Lima Santos, Timothy Olah, João Pedras-Vasconcelos, Ludovicus Staelens, Yoshiro Saito, Natasha Savoie, Kara Scheibner, Susan Spitz, Nilufer Tampal, Eric Thomas, Stephen Vinter, Jason Wakelin-Smith, Jan Welink, Jianing Zeng, Shaolian Zhou
The 2016 10th Workshop on Recent Issues in Bioanalysis (10(th) WRIB) took place in Orlando, Florida with participation of close to 700 professionals from pharmaceutical/biopharmaceutical companies, biotechnology companies, contract research organizations, and regulatory agencies worldwide. WRIB was once again a 5-day, weeklong event - A Full Immersion Week of Bioanalysis including Biomarkers and Immunogenicity. As usual, it is specifically designed to facilitate sharing, reviewing, discussing and agreeing on approaches to address the most current issues of interest including both small and large molecules involving LCMS, hybrid LBA/LCMS, and LBA approaches, with the focus on biomarkers and immunogenicity...
December 2016: Bioanalysis
https://www.readbyqxmd.com/read/27846931/-ccafu-french-national-guidelines-2016-2018-on-retroperitoneal-sarcoma
#3
T Murez, A Fléchon, L Rocher, P Camparo, N Morel-Journel, P-H Savoie, L Ferretti, P Sèbe, A Méjean, X Durand
INTRODUCTION: The purpose of this article was established by the external genitalia group CCAFU recommandations for diagnosis, treatment and monitoring of retroperitoneal sarcomas, intended for urologists. MATERIAL AND METHODS: The multidisciplinary working group has updated the 2013 guidelines, based on an exhaustive review of the literature on PubMed, valued references, level of evidence, to assign grades of recommendation. RESULTS: From a clinical suspicion evoking a RPS, computed tomography thoraco abdominal and pelvic is the gold standard...
November 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27846930/-ccafu-french-national-guidelines-2016-2018-on-penile-cancer
#4
P Sèbe, L Ferretti, P-H Savoie, N Morel-Journel, A Fléchon, T Murez, L Rocher, P Camparo, A Méjean, X Durand
INTRODUCTION: The aim of this work is to establish guidelines proposed by the external genital organ group of the CCAFU for the diagnosis, treatment and follow-up of penile cancer. MATERIAL AND METHODS: The multidisciplinary working party studied 2013 guidelines exhaustively reviewed the literature, and evaluated references and their level of proof in order to attribute grades of recommandation. RESULTS: The most common histological type is squamous cell carcinoma...
November 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27846929/-ccafu-french-national-guidelines-2016-2018-on-testicular-germ-cell-tumors
#5
X Durand, A Fléchon, T Murez, L Rocher, P Camparo, N Morel-Journel, P-H Savoie, L Ferretti, P Sèbe, A Méjean
INTRODUCTION: The purpose of the oncologic comitee of the french association of urology was to establish guidelines proposed by the external genital organ group, for the diagnosis, treatment and follow-up of the germ cell tumours of the testis. MATERIAL AND METHODS: The multidisciplinary working group studied 2013 guidelines, exhaustively reviewed the literature, and evaluated references and their level of proof in order to attribute grades of recommandation. RESULTS: The initial workup of testicular cancer is based on clinical, laboratory (AFP, total hCG, LDH) and imaging assessment (scrotal ultrasound and chest, abdomen and pelvis computed tomography)...
November 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27842915/age-at-presentation-and-management-of-pediatric-intussusception-a-pediatric-health-information-system-database-study
#6
Kate B Savoie, Fridtjof Thomas, Simonne S Nouer, Max R Langham, Eunice Y Huang
BACKGROUND: Intussusception is uncommon in children older than 3 years, and use of enema reduction in older children is controversial. We sought to determine whether older children are at greater risk of requiring operative intervention and/or having pathology causing lead points, such that enema reduction should not be attempted. METHODS: The Pediatric Health Information System database was reviewed from January 1, 2009-June 30, 2014. Patients were followed for 6 months from initial presentation or until bowel resection occurred...
November 11, 2016: Surgery
https://www.readbyqxmd.com/read/27799834/a-comparison-of-functional-outcomes-in-patients-undergoing-revision-arthroscopic-repair-of-massive-rotator-cuff-tears-with-and-without-arthroscopic-suprascapular-nerve-release
#7
Felix H Savoie, Mark Zunkiewicz, Larry D Field, William H Replogle, Michael J O'Brien
PURPOSE: This study was designed to compare functional outcomes in patients undergoing revision repair of massive rotator cuff tears (retracted medial to the glenoid) with Goutallier Grade 4 atrophy and concomitant release of the suprascapular nerve to a similar group of patients with Grade 3 atrophy undergoing revision rotator cuff repair (RTCR) without nerve release. We hypothesized that patients undergoing nerve release would have more favorable functional outcomes as measured by the Modified University of California at Los Angeles shoulder rating scale (UCLA)...
2016: Open Access Journal of Sports Medicine
https://www.readbyqxmd.com/read/27794616/sequential-c-h-arylation-and-enantioselective-hydrogenation-enables-ideal-asymmetric-entry-to-the-indenopiperidine-core-of-an-11%C3%AE-hsd-1-inhibitor
#8
Xudong Wei, Bo Qu, Xingzhong Zeng, Jolaine Savoie, Keith R Fandrick, Jean-Nicolas Desrosiers, Sergei Tcyrulnikov, Maurice A Marsini, Frederic G Buono, Zhibin Li, Bing-Shiou Yang, Wenjun Tang, Nizar Haddad, Osvaldo Gutierrez, Jun Wang, Heewon Lee, Shengli Ma, Scot Campbell, Jon C Lorenz, Matthias Eckhardt, Frank Himmelsbach, Stefan Peters, Nitinchandra Dahyabhai Patel, Zhulin Tan, Nathan K Yee, Jinhua J Song, Frank Roschangar, Marisa C Kozlowski, Chris H Senanayake
A concise asymmetric synthesis of an 11β-HSD-1 inhibitor has been achieved using inexpensive starting materials with excellent step-economy at low catalyst loadings. The catalytic enantioselective total synthesis of 1 was accomplished in 7 steps and 38% overall yield aided by the development of an innovative, sequential strategy involving Pd-catalyzed pyridinium C-H arylation and Ir-catalyzed asymmetric hydrogenation of the resulting fused tricyclic indenopyridinium salt highlighted by the use of a unique P,N-ligand (MeO-BoQPhos) with 1000 ppm of [Ir(COD)Cl]2...
October 30, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27777028/-1896-how-nascent-radiotherapy-gathered-roentgen-pasteur-and-the-lumi%C3%A3-re-brothers
#9
N Foray
On the 4th July, 1896, in his medical office of Les Échelles (Savoie, France), Victor Despeignes performed the very first radiotherapy against cancer, documented by indisputable proofs. However, the intellectual and practical approach that leads to this first radiotherapy may appear unexpected to date. Indeed, it is likely that the treatment that Despeignes applied to his neighbour, who did not suffer from stomach cancer, was born with the indirect support of the Lumière brothers, on the basis of a biological theory (the parasitory theory of cancer) that is irrelevant today, with an experimental protocol based on experiments performed on tuberculosis et in a bifractionated model linked by the constraints of a district medical doctor...
December 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/27717526/human-brucellosis-in-france-in-the-21st-century-results-from-national-surveillance-2004-2013
#10
A Mailles, B Garin-Bastuji, J P Lavigne, M Jay, A Sotto, M Maurin, I Pelloux, D O'Callaghan, V Mick, V Vaillant, H De Valk
: Brucellosis is a bacterial zoonotic disease mainly transmitted to humans by ruminants. In France, brucellosis has disappeared from ruminants herds. Human brucellosis surveillance is performed through mandatory notification and the national reference center. METHODS: We report the results of human brucellosis surveillance from 2004 to 2013 with regards to epidemiological, clinical and microbiological data. RESULTS: A total of 250 cases were notified, making an annual incidence of 0...
December 2016: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/27712081/2016-white-paper-on-recent-issues-in-bioanalysis-focus-on-biomarker-assay-validation-bav-part-1-small-molecules-peptides-and-small-molecule-biomarkers-by-lcms
#11
Eric Yang, Jan Welink, Stephanie Cape, Eric Woolf, Jens Sydor, Christopher James, Dina Goykhman, Mark Arnold, Neil Addock, Ronald Bauer, Michael Buonarati, Eugene Ciccimaro, Raj Dodda, Christopher Evans, Fabio Garofolo, Nicola Hughes, Rafiq Islam, Corey Nehls, Amanda Wilson, Chad Briscoe, Mark Bustard, Laura Coppola, Stephanie Croft, Dieter Drexler, Luca Ferrari, Daniela Fraier, Rand Jenkins, John Kadavil, Lloyd King, Wenkui Li, Gustavo Mendes Lima Santos, Adrien Musuku, Ragu Ramanathan, Yoshiro Saito, Natasha Savoie, Scott Summerfield, Rachel Sun, Nilufer Tampal, Steve Vinter, Jason Wakelin-Smith, Qin Yue
The 2016 10(th) Workshop on Recent Issues in Bioanalysis (10(th) WRIB) took place in Orlando, Florida with participation of close to 700 professionals from pharmaceutical/biopharmaceutical companies, biotechnology companies, contract research organizations, and regulatory agencies worldwide. WRIB was once again a 5-day, weeklong event - A Full Immersion Week of Bioanalysis including Biomarkers and Immunogenicity. As usual, it was specifically designed to facilitate sharing, reviewing, discussing and agreeing on approaches to address the most current issues of interest including both small and large molecule analysis involving LCMS, hybrid LBA/LCMS, and LBA approaches, with the focus on biomarkers and immunogenicity...
October 7, 2016: Bioanalysis
https://www.readbyqxmd.com/read/27709062/arthroscopic-distal-triceps-repair
#12
Tracy Ng, Lane N Rush, Felix H Savoie
In this note, we describe an arthroscopic repair of a degenerative tear of the triceps using a suture weave and an anatomic footprint anchor. We are able to assess, debride, and anatomically repair the distal triceps to its insertion. Compared with open procedures, this arthroscopic repair offers lower morbidity, faster recovery, and improved cosmesis. Our goal was to improve the function and strength of the elbow through this arthroscopic surgical fixation.
August 2016: Arthroscopy Techniques
https://www.readbyqxmd.com/read/27709045/arthroscopic-rotator-cuff-repair-with-concomitant-capsular-release
#13
Steven Giuseffi, Larry D Field, Thomas V Giel, Brian T Brislin, Felix H Savoie
Patients with rotator cuff tears may present with or subsequently develop concomitant shoulder stiffness. The treatment of rotator cuff tears in the face of passive glenohumeral motion loss is controversial. Preoperative shoulder stiffness has been considered by some a contraindication to rotator cuff repair. Some surgeons recommend staging surgical procedures and delaying rotator cuff repair until shoulder stiffness has resolved. However, this can lead to prolonged recovery times and patient dissatisfaction...
August 2016: Arthroscopy Techniques
https://www.readbyqxmd.com/read/27696424/yeast-and-bacteria-from-ensiled-high-moisture-maize-grains-as-potential-mitigation-agents-of-fumonisin-b1
#14
Ccori Martinez Tuppia, Vessela Atanasova-Penichon, Sylvain Chéreau, Nathalie Ferrer, Gisèle Marchegay, Jean-Michel Savoie, Florence Richard-Forget
BACKGROUND: Fumonisin B1 (FB1) is a mycotoxin produced by several Fusarium species and a very common contaminant of maize-based food and feed throughout the world. The selection and use of FB1-degrading microorganisms appears as a promising alternative to cope with the problem of toxicity towards humans and livestock. High moisture maize grain silage which is based on natural maize fermentation could be an interesting reservoir of such microorganisms. RESULTS: Using an in vitro simulated silage model with FB1 naturally contaminated grains, we demonstrated a significant raw decrease in FB1 during ensiling process ascribed to biodegradation mechanisms...
October 3, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27680778/complicated-congenital-retinoschisis
#15
Brian T Savoie, Philip J Ferrone
PURPOSE: To describe the treatment and natural history of a patient with complicated congenital retinoschisis. METHODS: A retrospective case report. A 10-month-old boy with congenital retinoschisis presented with tractional retinal detachments and foveal schisis in both eyes. RESULTS: On presentation, vision was decreased in both eyes with presumed amblyopia of the left eye. Funduscopic examination revealed bilateral foveal schisis and tractional retinal detachment involving the macula...
September 27, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27661252/synthesis-of-enantioenriched-2-alkyl-piperidine-derivatives-through-asymmetric-reduction-of-pyridinium-salts
#16
Bo Qu, Hari P R Mangunuru, Xudong Wei, Keith R Fandrick, Jean-Nicolas Desrosiers, Joshua D Sieber, Dmitry Kurouski, Nizar Haddad, Lalith P Samankumara, Heewon Lee, Jolaine Savoie, Shengli Ma, Nelu Grinberg, Max Sarvestani, Nathan K Yee, Jinhua J Song, Chris H Senanayake
An Ir-catalyzed enantioselective hydrogenation of 2-alkyl-pyridines has been developed using ligand MeO-BoQPhos. High levels of enantioselectivities up to 93:7 er were obtained. The resulting enantioenriched piperidines can be readily converted into biologically interesting molecules such as the fused tricyclic structures 5, 6, and 7 in 99:1 er, providing a novel, concise synthetic route to this family of chiral piperidine-containing compounds.
October 7, 2016: Organic Letters
https://www.readbyqxmd.com/read/27619739/duramycin-porphyrin-conjugates-for-targeting-of-tumour-cells-using-photodynamic-therapy
#17
Laura J Broughton, Francesca Giuntini, Huguette Savoie, Francesca Bryden, Ross W Boyle, Anthony Maraveyas, Leigh A Madden
Duramycin, through binding with phosphatidylethanolamine (PE), has been shown to be a selective molecular probe for the targeting and imaging of cancer cells. Photodynamic therapy aims to bring about specific cytotoxic damage to tumours through delivery of a photosensitising agent and light irradiation. Conjugation to biological molecules that specifically target cancer has been shown to increase photosensitiser (PS) selectivity and decrease damage to surrounding normal tissue. The aim of this study was to target tumour cells with a PE-specific PS therefore duramycin was conjugated to a porphyrin based PS which was achieved via direct reaction with the ε-amino group on the lysine residue near duramycin's N-terminal...
October 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27598895/decreasing-orthopaedic-surgical-site-infections-a-new-perioperative-protocol
#18
Murphy P Martin, Michael J O'Brien, Felix H Savoie
BACKGROUND: Little data exist regarding the effects of prophylactic perioperative protocol on reducing surgical site infections. Based on national efforts to prevent SSIs and current evidence in the literature supporting the importance of perioperative prophylaxis, it would seem logical that expanding upon current perioperative protocol would help prevent SSIs. HYPOTHESIS: Multiple variables present risk factors in the development of SSIs in the perioperative period, and optimization of patient management during this time with a series of non-invasive and inexpensive protocols may help prevent SSIs...
July 2016: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/27586849/health-disparities-in-infants-with-hypertrophic-pyloric-stenosis
#19
Alexander Feliz, Janette L Holub, Nima Azarakhsh, Marielena Bachier-Rodriguez, Kate B Savoie
BACKGROUND: This study investigates whether health disparities exist in infants with hypertrophic pyloric stenosis (HPS), to identify factors affecting definitive treatment, and if more morbidity occurs. METHODS: A 6-year retrospective analysis was performed on infants with HPS. Analysis of variance was used to evaluate the impact of socioeconomic factors on disease severity and hospitalization. General linear models were used to assess the impact of risk factors on the outcomes...
August 4, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27584254/comparison-of-salt-glycerol-and-salt-glycerol-induced-hyperhydration-on-fluid-balance-in-young-men-640-board-3-june-1-1-00-pm-3-00-pm
#20
Eric Db Goulet, Félix-Antoine Savoie, Michel Mélançon, Adrien De La Flore
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
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