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https://www.readbyqxmd.com/read/29650457/-non-palpable-testicular-tumors-in-adults-a-management-based-on-imaging-issue-from-the-french-urologic-association-genital-cancer-committee-s-edit
#1
L Rocher, L Feretti, P Camparo, P H Savoie, N Morel-Journel, T Murez, P Sebe, A Flechon, A Méjean, X Durand
BACKGROUND: Help in management of non-palpable testicular tumors. French Urologic Association Genital cancer committee's Edit. OBJECTIVES: To review their characterization at imaging findings of non-palpable testicular tumors. DOCUMENTARY SOURCES: Literature review (PubMed, Medline) of urological and radiological studies dealing with testicular tumors using keywords: non-palpable/incidental testicular tumors; color Doppler ultrasound; US elastography; magnetic resonance imaging; contrast enhanced sonography; partial surgery...
April 9, 2018: Progrès en Urologie
https://www.readbyqxmd.com/read/29648558/photo-induced-anticancer-activity-and-singlet-oxygen-production-of-prodigiosenes
#2
Huguette Savoie, Carlotta Figliola, Estelle Marchal, Bry W Crabbe, Geniece L Hallett-Tapley, Ross W Boyle, Alison Thompson
The photo-induced cytotoxicity of prodigiosenes is reported. One prodigiosene represents a synthetic analogue of the natural product prodigiosin, and two are conjugated to molecules that target the estrogen receptor (ER). A comparison of incubation and irradiation frameworks for the three prodigiosenes is reported, with activity against ER- and ER+ lines explored. Furthermore, the ability of the three prodigiosenes to photosensitise the production of singlet oxygen is demonstrated, shedding mechanistic light onto possible photodynamic therapeutic effects of this class of tripyrroles...
April 12, 2018: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/29645036/the-control-of-stereochemistry-by-the-pentafluorosulfanyl-group
#3
Paul R Savoie, Cortney N von Hahmann, Alexander Penger, Zheng Wei, John T Welch
The influence of pentafluorosulfanylation on biological activity has been revealed in numerous comparative studies of biologically active compounds, but considerably less is known about the influence of pentafluorosulfanylation on reactivity. Among the distinctive properties of the pentafluorosulfanyl group is the profound dipole moment that results from introduction of this substituent. It has been shown that dipolar effects coupled with the steric demand of the SF5 group may be employed to influence the stereochemistry of reactions, especially those processes with significant charge separation in the transition state...
April 12, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29617042/use-of-a-gastroschisis-feeding-guideline-to-improve-standardization-of-care-and-patient-outcomes-at-an-urban-children-s-hospital
#4
R Colby Passaro, Kate B Savoie, Eunice Y Huang
BACKGROUND: This study examined clinical outcomes associated with the use of a gastroschisis-specific (GS) feeding advancement guideline. METHODS: We performed a retrospective study of all simple gastroschisis babies (N = 65) treated between June 2009June 2015. We compared patients treated on a postintestinal surgery guideline using either a 1-day (1D) or 3-day (3D) feeding advancement from August 2009-August 2013 with infants treated on a GS guideline from September 2013-June 2015...
April 4, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29596749/synthesis-and-characterization-of-temperature-sensitive-and-chemically-cross-linked-poly-n-isopropylacrylamide-photosensitizer-hydrogels-for-applications-in-photodynamic-therapy
#5
Simin Belali, Huguette Savoie, Jessica M O'Brien, Attilio A Cafolla, Barry O'Connell, Ali Reza Karimi, Ross W Boyle, Mathias O Senge
A novel poly(N-isopropylacrylamide) (PNIPAM) hydrogel containing different photosensitizers (protoporphyrin IX (PpIX), pheophorbide a (Pba) and protoporphyrin IX dimethyl ester (PpIX-DME)) has been synthesized with a significant improvement in water-solubility and potential for PDT applications compared to the individual photosensitizers (PSs). Conjugation of PpIX, Pba and PpIX-DME to the poly(N-isopropylacrylamide) chain was achieved using the dispersion polymerization method. This study describes how the use of nanohydrogel structures to deliver a photosensitizer with low water-solubility and high aggregation tendencies in polar solvents overcomes these limitations...
March 29, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29567710/a-nonconjugated-radical-polymer-glass-with-high-electrical-conductivity
#6
Yongho Joo, Varad Agarkar, Seung Hyun Sung, Brett M Savoie, Bryan W Boudouris
Solid-state conducting polymers usually have highly conjugated macromolecular backbones and require intentional doping in order to achieve high electrical conductivities. Conversely, single-component, charge-neutral macromolecules could be synthetically simpler and have improved processibility and ambient stability. We show that poly(4-glycidyloxy-2,2,6,6-tetramethylpiperidine-1-oxyl), a nonconjugated radical polymer with a subambient glass transition temperature, underwent rapid solid-state charge transfer reactions and had an electrical conductivity of up to 28 siemens per meter over channel lengths up to 0...
March 23, 2018: Science
https://www.readbyqxmd.com/read/29525024/elbow-injuries-common-problems-and-solutions
#7
REVIEW
Felix H Savoie
The elbow is one of the more difficult joints in which to obtain good results. Common issues include placement of correct portals, neuropraxia, ankylosis, heterotopic bone formation, and simple failure of the procedure. Common solutions include portal placement safeguards, nerve protection, early motion and cryocompression, oral or injectable steroids, radiation therapy, secure stabilization, and postoperative protection and rehabilitation based on available evidence and imaging.
April 2018: Clinics in Sports Medicine
https://www.readbyqxmd.com/read/29405358/corrigendum-potent-and-selective-inhibitors-of-11%C3%AE-hydroxysteroid-dehydrogenase-type-1-labeled-with-carbon-13-and-carbon-14
#8
EDITORIAL
Bachir Latli, Matt Hrapchak, Jolaine Savoie, Yongda Zhang, Carl A Busacca, Chris H Senanayake
No abstract text is available yet for this article.
February 6, 2018: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29364306/synthesis-of-a-novel-her2-targeted-aza-bodipy-antibody-conjugate-synthesis-photophysical-characterisation-and-in-vitro-evaluation
#9
Miffy H Y Cheng, Antoine Maruani, Huguette Savoie, Vijay Chudasama, Ross W Boyle
We herein report the synthesis and analysis of a novel aza-BODIPY-antibody conjugate, formed by controlled and regioselective bioconjugation methodology. Employing the clinically relevant antibody, which targets HER2 positive cancers, represents an excellent example of an antibody targeting strategy for this class of near-IR emitting fluorophore. The NIR fluorescence and binding properties were validated through in vitro studies using live cell confocal imaging.
February 14, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29216717/assembly-of-high-potency-photosensitizer-antibody-conjugates-through-application-of-dendron-multiplier-technology
#10
Francesca Bryden, Antoine Maruani, João M M Rodrigues, Miffy H Y Cheng, Huguette Savoie, Andrew Beeby, Vijay Chudasama, Ross W Boyle
Exploitation of photosensitizers as payloads for antibody-based anticancer therapeutics offers a novel alternative to the small pool of commonly utilized cytotoxins. However, existing bioconjugation methodologies are incompatible with the requirement of increased antibody loading without compromising antibody function, stability, or homogeneity. Herein, we describe the first application of dendritic multiplier groups to allow the loading of more than 4 porphyrins to a full IgG antibody in a site-specific and highly homogeneous manner...
January 17, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29205064/2017-white-paper-on-recent-issues-in-bioanalysis-a-global-perspective-on-immunogenicity-guidelines-biomarker-assay-performance-part-3-lba-immunogenicity-biomarkers-and-pk-assays
#11
Shalini Gupta, Susan Richards, Lakshmi Amaravadi, Steven Piccoli, Binodh Desilva, Renuka Pillutla, Lauren Stevenson, Devangi Mehta, Montserrat Carrasco-Triguero, Robert Neely, Michael Partridge, Roland F Staack, Xuemei Zhao, Boris Gorovits, Gerry Kolaitis, Giane Sumner, Kay-Gunnar Stubenrauch, Linglong Zou, Shashi Amur, Chris Beaver, Isabella Berger, Flora Berisha, Herbert Birnboeck, Joe Bower, Seongeun Julia Cho, Isabelle Cludts, Laurent Cocea, Lorella Di Donato, Saloumeh Fischer, Stephanie Fraser, Fabio Garofolo, Sam Haidar, Jonathan Haulenbeek, Charles Hottenstein, Jenny Hu, Akiko Ishii-Watabe, Rafiq Islam, Darshana Jani, John Kadavil, John Kamerud, Daniel Kramer, Pekka Kurki, Stephen MacMannis, Jim McNally, Ashley Mullan, Apollon Papadimitriou, João Pedras-Vasconcelos, Soma Ray, Afshin Safavi, Yoshiro Saito, Natasha Savoie, Marianne Scheel Fjording, Kara Scheibner, John Smeraglia, An Song, Bruce Stouffer, Nilufer Tampal, Barry van der Strate, Thorsten Verch, Jan Welink, Yuanxin Xu, Tong-Yuan Yang, Lilian Yengi, Jianing Zeng, Yan Zhang, Yanhua Zhang, Stephen Zoog
The 2017 11th Workshop on Recent Issues in Bioanalysis took place in Los Angeles/Universal City, California, on 3-7 April 2017 with participation of close to 750 professionals from pharmaceutical/biopharmaceutical companies, biotechnology companies, contract research organizations and regulatory agencies worldwide. WRIB was once again a 5-day, week-long event - a full immersion week of bioanalysis, biomarkers and immunogenicity. As usual, it was specifically designed to facilitate sharing, reviewing, discussing and agreeing on approaches to address the most current issues of interest including both small- and large-molecule analysis involving LC-MS, hybrid ligand-binding assay (LBA)/LC-MS and LBA approaches...
December 2017: Bioanalysis
https://www.readbyqxmd.com/read/29205053/2017-white-paper-rise-of-hybrid-lba-lcms-immunogenicity-assays-part-2-hybrid-lba-lcms-biotherapeutics-biomarkers-immunogenicity-assays-and-regulatory-agencies-inputs
#12
Hendrik Neubert, An Song, Anita Lee, Cong Wei, Jeff Duggan, Keyang Xu, Eric Woolf, Chris Evans, Joe Palandra, Omar Laterza, Shashi Amur, Isabella Berger, Mark Bustard, Mark Cancilla, Shang-Chiung Chen, Seongeun Julia Cho, Eugene Ciccimaro, Isabelle Cludts, Laurent Cocea, Celia D'Arienzo, Lieza Danan-Leon, Lorella Di Donato, Fabio Garofolo, Sam Haidar, Akiko Ishii-Watabe, Hao Jiang, John Kadavil, Sean Kassim, Pekka Kurki, Olivier Le Blaye, Kai Liu, Rod Mathews, Gustavo Mendes Lima Santos, Makoto Niwa, João Pedras-Vasconcelos, Mark Qian, Brian Rago, Ola Saad, Yoshiro Saito, Natasha Savoie, Dian Su, Matthew Szapacs, Nilufer Tampal, Stephen Vinter, Jian Wang, Jan Welink, Emma Whale, Amanda Wilson, Y-J Xue
The 2017 11th Workshop on Recent Issues in Bioanalysis (11th WRIB) took place in Los Angeles/Universal City, California on 3-7 April 2017 with participation of close to 750 professionals from pharmaceutical/biopharmaceutical companies, biotechnology companies, contract research organizations and regulatory agencies worldwide. WRIB was once again a 5-day, weeklong event - a full immersion week of bioanalysis, biomarkers and immunogenicity. As usual, it was specifically designed to facilitate sharing, reviewing, discussing and agreeing on approaches to address the most current issues of interest including both small and large molecule analysis involving LCMS, hybrid ligand binding assay (LBA)/LCMS and LBA approaches...
December 2017: Bioanalysis
https://www.readbyqxmd.com/read/29203585/safety-and-efficacy-of-selinexor-in-relapsed-or-refractory-multiple-myeloma-and-waldenstrom-macroglobulinemia
#13
Christine Chen, David Siegel, Martin Gutierrez, Meagan Jacoby, Craig C Hofmeister, Nashat Gabrail, Rachid Baz, Morten Mau-Sorensen, Jesus G Berdeja, Michael Savona, Lynn Savoie, Suzanne Trudel, Nuchanan Areethamsirikul, T J Unger, Tami Rashal, Tim Hanke, Michael Kauffman, Sharon Shacham, Donna Reece
Novel therapies are needed for patients with relapsed or refractory multiple myeloma (MM). We conducted a multicenter, phase 1 study in advanced hematological malignancies to assess the safety, efficacy, and recommended phase 2 dose (RP2D) of oral selinexor, a selective inhibitor of the nuclear export protein XPO1. In the dose-escalation phase, 25 patients with heavily pretreated MM (22) or Waldenstrom macroglobulinemia (3) were administered selinexor (3-60 mg/m2 ) in 8 or 10 doses per 28-day cycle. In the dose-expansion phase, 59 patients with MM received selinexor at 45 or 60 mg/m2 with 20 mg dexamethasone, twice weekly in 28-day cycles, or selinexor (40 or 60 mg flat dose) without corticosteroids in 21-day cycles...
February 22, 2018: Blood
https://www.readbyqxmd.com/read/29164165/platelet-rich-plasma-for-primary-treatment-of-partial-ulnar-collateral-ligament-tears-mri-correlation-with-results
#14
J Banks Deal, Ed Smith, Wendell Heard, Michael J O'Brien, Felix H Savoie
Background: Jobe revolutionized the treatment of medial ulnar collateral ligament (MUCL) tears with his reconstruction technique. However, not all MUCL injuries require operative management; Rettig showed that 42% of MUCL injuries respond to conservative management. This was improved by Podesta, who showed that augmentation of nonoperative management with platelet-rich plasma (PRP) and magnetic resonance imaging (MRI) for detecting partial MUCL tears resulted in significantly higher success rates...
November 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29148835/2017-white-paper-on-recent-issues-in-bioanalysis-aren-t-bmv-guidance-guidelines-scientific-part-1-lcms-small-molecules-peptides-and-small-molecule-biomarkers
#15
Jan Welink, Eric Yang, Nicola Hughes, Brian Rago, Eric Woolf, Jens Sydor, Laura Coppola, Brad Ackermann, Wenkui Li, Stephen C Alley, Mark Arnold, Isabella Berger, Chad Briscoe, Michael Buonarati, Mark Bustard, Mark Cancilla, Seongeun Julia Cho, Jeff Duggan, Daniela Fraier, Fabio Garofolo, Rachel Green, Sam Haidar, Lucinda Hittle, Akiko Ishii-Watabe, Rafiq Islam, Rand Jenkins, Barry Jones, John Kadavil, Sean Kassim, Olga Kavetska, Olivier Le Blaye, Anita Lee, Hanlan Liu, John Mehl, Gustavo Mendes Lima Santos, Adrien Musuku, Ragu Ramanathan, Yoshiro Saito, Natasha Savoie, Scott Summerfield, Sekhar Surapaneni, Matthew Szapacs, Nilufer Tampal, Tom Verhaeghe, Stephen Vinter, Emma Whale
The 2017 11th Workshop on Recent Issues in Bioanalysis (11th WRIB) took place in Los Angeles/Universal City, California from 3 April 2017 to 7 April 2017 with participation of close to 750 professionals from pharmaceutical/biopharmaceutical companies, biotechnology companies, contract research organizations and regulatory agencies worldwide. WRIB was once again a 5-day, weeklong event - A Full Immersion Week of Bioanalysis, Biomarkers and Immunogenicity. As usual, it was specifically designed to facilitate sharing, reviewing, discussing and agreeing on approaches to address the most current issues of interest including both small and large molecule analysis involving LCMS, hybrid LBA/LCMS and ligand-binding assay (LBA) approaches...
November 2017: Bioanalysis
https://www.readbyqxmd.com/read/29140136/salt-glycerol-induced-hyperhydration-enhances-fluid-retention-more-than-salt-or-glycerol-induced-hyperhydration
#16
Eric D B Goulet, Adrien De La Flore, Félix A Savoie, Jonathan Gosselin
Hyperhydration has been demonstrated to improve work capacity and cardiovascular and thermoregulatory functions, enhance orthostatic tolerance, slow or neutralize bone demineralization and decrease post-dive bubble formation. Adding sodium or glycerol to a hyperhydration solution optimizes fluid retention. Sodium and glycerol produce their effect through different physiological mechanisms. If combined into a hyperhydration solution their impact on fluid retention could potentially be greater than their singular effect...
November 15, 2017: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/29131220/highly-regioselective-gold-catalyzed-formal-hydration-of-propargylic-gem-difluorides
#17
Jean-Denys Hamel, Tatsuru Hayashi, Mélissa Cloutier, Paul R Savoie, Olivier Thibeault, Meggan Beaudoin, Jean-François Paquin
Herein, we report a highly regioselective gold-catalyzed formal hydration of propargylic gem-difluorides. Not only does this transformation provide access to versatile fluorinated building blocks that were difficult or hardly possible to access beforehand, but it also represents a rare case of a highly regioselective gold-catalyzed hydroalkoxylation of internal alkynes and puts forward the utility of the difluoromethylene unit as a directing group in catalysis.
November 29, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29122187/dynamic-and-static-shoulder-strength-relationship-and-predictive-model
#18
Alison C McDonald, Spencer M Savoie, Daanish M Mulla, Peter J Keir
Static strength is typically used to standardize occupational tasks in an effort to limit over-exertion injuries; however, workplace tasks are commonly dynamic in nature. The purpose of this investigation was to assess factors influencing isokinetic shoulder strength and to develop predictive equations for isokinetic shoulder flexion and extension strength using isometric strength. Fifteen women performed a set of concentric isokinetic and isometric shoulder flexion and extension maximal exertions across a series of movement planes, angular velocities, and grip types...
February 2018: Applied Ergonomics
https://www.readbyqxmd.com/read/29102007/editorial-commentary-is-shoulder-joint-preservation-an-endangered-species-let-s-save-the-glenoid
#19
EDITORIAL
Felix H Savoie
Joint preservation in young patients has always been the mission of arthroscopists worldwide since Bob Jackson visited Dr. Watanabe and brought the arthroscope to North America. In patients with shoulder glenohumeral arthritis, joint preservation is paramount and advanced arthroscopic techniques are of significant benefit. A recent publication shows 77% satisfactory outcomes, provides critical details on patient selection, and shows that a cohort of (younger) patients with shoulder osteoarthritis may do well after isolated glenoid resurfacing...
November 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29099610/the-decennial-index-of-the-white-papers-in-bioanalysis-a-decade-of-recommendations-2007-2016
#20
Wei Garofolo, Natasha Savoie
No abstract text is available yet for this article.
November 2017: Bioanalysis
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