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https://www.readbyqxmd.com/read/28152731/clinical-trial-enrollment-expansion-to-the-community
#1
Jessica A Zerillo, Andrea Kruse, Natalie Faye Sinclair, Maureen Patrick, Lauren McGovern, Frances Fuller, Kelly O'Neil, Nicole Hixon, Kristie Weeks, Bruce E Johnson, Ian E Krop, Jen Savoie, Farah Daftary, Michael Constantine, Mona S Kaddis, Humberto A Rossi, Naeem Tahir, Andrew David Norden
: 112 Background: Oncology patients at community cancer practices generally do not access clinical trials to the same degree as patients at academic medical centers. Collaborations between research and clinical teams across academic hospitals and their affiliated community sites may help to improve this disparity. METHODS: To improve clinical trial enrollment, a multidisciplinary team of research and clinical staff from the Dana-Farber Cancer Institute main campus and a community-based satellite site implemented a program to enhance identification of breast cancer patients eligible for clinical trials...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28151569/nanososg-a-nanostructured-fluorescent-probe-for-the-detection-of-intracellular-singlet-oxygen
#2
Rubén Ruiz-González, Roger Bresolí-Obach, Òscar Gulías, Montserrat Agut, Huguette Savoie, Ross W Boyle, Santi Nonell, Francesca Giuntini
A biocompatible fluorescent nanoprobe for singlet oxygen ((1) O2 ) detection in biological systems was designed, synthesized, and characterized, that circumvents many of the limitations of the molecular probe Singlet Oxygen Sensor Green(®) (SOSG). This widely used commercial singlet oxygen probe was covalently linked to a polyacrylamide nanoparticle core using different architectures to optimize the response to (1) O2 . In contrast to its molecular counterpart, the optimum SOSG-based nanoprobe, which we call NanoSOSG, is readily internalized by E...
February 2, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28118063/anthropometry-in-long-term-survivors-of-acute-lymphoblastic-leukemia-in-childhood-and-adolescence
#3
Laura Collins, Lesley Beaumont, Amy Cranston, Stefanie Savoie, Trishana Nayiager, Ronald Barr
PURPOSE: Body mass index (BMI) is an inadequate measure of nutritional status in children and adolescents with cancer as it does not distinguish muscle from adipose tissue. However, arm anthropometry offers simple assessments of fat mass and lean body mass; especially valuable in low- and middle-income countries where the great majority of young people with cancer live and access to sophisticated expensive measures of body composition is markedly limited. METHODS: The nutritional status of 75 long-term survivors of acute lymphoblastic leukemia was assessed by arm anthropometry, in addition to BMI, in a cross-sectional cohort study...
January 24, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28115276/allogeneic-hematopoietic-cell-transplant-for-adult-chronic-myelomonocytic-leukemia
#4
Hien D Liu, Kwang Woo Ahn, Zhen-Huan Hu, Mehdi Hamadani, Taiga Nishihori, Baldeep Wirk, Amer Beitinjaneh, David Rizzieri, Michael R Grunwald, Mitchell Sabloff, Richard F Olsson, Ashish Bajel, Christopher Bredeson, Andrew Daly, Yoshihiro Inamoto, Navneet Majhail, Ayman Saad, Vikas Gupta, Aaron Gerds, Adriana Malone, Martin Tallman, Ran Reshef, David I Marks, Edward Copelan, Usama Gergis, Mary Lynn Savoie, Celalettin Ustun, Mark R Litzow, Jean-Yves Cahn, Tamila Kindwall-Keller, Gorgun Akpek, Bipin N Savani, Mahmoud Aljurf, Jacob M Rowe, Peter H Wiernik, Jack W Hsu, Jorge Cortes, Matt Kalaycio, Richard Maziarz, Ronald Sobecks, Uday Popat, Edwin Alyea, Wael Saber
Allogeneic hematopoietic cell transplantation (HCT) is potentially curative for patients with chronic myelomonocytic leukemia (CMML), however, few data exist regarding prognostic factors and transplant outcomes. We performed this retrospective study to identify prognostic factors for post-transplant outcomes. The CMML-specific prognostic scoring system (CPSS) has been validated in subjects receiving non-transplant therapy and was included in our study. From 2001-2012, there were 209 adult subjects who received HCT for CMML reported to the Center for International Blood and Marrow Transplant Research (CIBMTR)...
January 20, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28111599/nickel-catalyzed-c-3-direct-arylation-of-pyridinium-ions-for-the-synthesis-of-1-azafluorenes
#5
Jean-Nicolas Desrosiers, Xudong Wei, Osvaldo Gutierrez, Jolaine Savoie, Bo Qu, Xingzhong Zeng, Heewon Lee, Nelu Grinberg, Nizar Haddad, Nathan K Yee, Frank Roschangar, Jinhua J Song, Marisa C Kozlowski, Chris H Senanayake
The direct arylation of pyridine substrates using non-precious catalysts is underdeveloped but highly desirable due to its efficiency to access important motifs while being extremely cost-effective. The first nickel-catalyzed C-3 direct arylation of pyridine derivatives to provide a new approach to valuable 1-azafluorene pharmacophore frameworks was developed. This transformation is accomplished using air-stable nickel catalyst precursors combined with phenanthroline ligands and tolerates a variety of substituents...
August 1, 2016: Chemical Science
https://www.readbyqxmd.com/read/28075599/enhancing-cation-diffusion-and-suppressing-anion-diffusion-via-lewis-acidic-polymer-electrolytes
#6
Brett M Savoie, Michael A Webb, Thomas F Miller
Solid polymer electrolytes (SPEs) have the potential to increase both the energy density and stability of lithium-based batteries, but low Li(+) conductivity remains a barrier to technological viability. SPEs are designed to maximize Li(+) diffusivity relative to the anion while maintaining sufficient salt solubility. It is thus remarkable that poly(ethylene oxide) (PEO), the most widely used SPE, exhibits Li(+) diffusivity that is an order of magnitude smaller than that of typical counterions at moderate salt concentrations...
January 23, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28036172/improved-scaling-of-molecular-network-calculations-the-emergence-of-molecular-domains
#7
Adam G Gagorik, Brett Savoie, Nick Jackson, Ankit Agrawal, Alok Choudhary, Mark A Ratner, George C Schatz, Kevin L Kohlstedt
The design of materials needed for the storage, delivery, and conversion of (re)useable energy is still hindered by the lack of new, hierarchical molecular screening methodologies that encode information on more than one length scale. Using a molecular network theory as a foundation, we show that to describe charge transport in disordered materials the network methodology must be scaled-up. We detail the scale-up through the use of adjacency lists and depth first search algorithms for during operations on the adjacency matrix...
January 19, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/27986459/-oncological-results-of-active-surveillance-in-prostate-cancer-a-retrospective-multicentric-cohort
#8
P Mortier, C Bastide, E Lechevallier, J Walz, R Fournier, P-H Savoie, K Ben Othman, R Giorgi, M André, S Giusiano, D Rossi
PURPOSE: To report oncological outcomes of patients with prostate cancer undergoing active surveillance according to SURACAP criteria. METHODS: This multicentric study included patients who were initially treated with active surveillance for localized prostate cancer according to the SURACAP criteria. The duration of active surveillance as well as the causes of discontinuing the protocol and the definitive pathological results of patients who further underwent radical prostatectomy were retrospectively evaluated...
December 13, 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27972555/development-of-a-global-model-for-the-economic-evaluation-of-pharmacogenomics-tests-for-early-stage-breast-cancer-treatment
#9
M Martinho Lemay, K Mathurin, M Savoie, J Lachaine
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27972554/development-of-a-global-model-for-the-economic-evaluation-of-personalized-medicine-for-the-treatment-of-prostate-cancer
#10
Piché-Richard, K Mathurin, M Savoie, J Lachaine
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27971555/development-of-a-global-model-for-the-economic-evaluation-of-a-biomarker-for-the-treatment-of-uncontrolled-moderate-to-severe-asthma
#11
A Castonguay, K Mathurin, M Savoie, J Lachaine
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27964852/increasing-fruit-and-vegetable-intake-among-children-and-youth-through-gardening-based-interventions-a-systematic-review
#12
Mateja R Savoie-Roskos, Heidi Wengreen, Carrie Durward
Although there are numerous health benefits associated with eating fruit and vegetables (F/V), few children are consuming recommended amounts. Gardening interventions have been implemented in various settings in an effort to increase children's F/V consumption by expanding knowledge, exposure, and preferences for a variety of F/V. The purpose of this review was to identify the effectiveness of gardening interventions that have been implemented to increase F/V consumption among children. A systematic review was conducted using four electronic databases: Web of Science, PubMed, Scopus, and the Cumulative Index to Nursing and Allied Health Literature...
February 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/27855512/2016-white-paper-on-recent-issues-in-bioanalysis-focus-on-biomarker-assay-validation-bav-part-3-lba-biomarkers-and-immunogenicity
#13
Susan Richards, Lakshmi Amaravadi, Renuka Pillutla, Herbert Birnboeck, Albert Torri, Kyra J Cowan, Apollon Papadimitriou, Fabio Garofolo, Christina Satterwhite, Steven Piccoli, Bonnie Wu, Corinna Krinos-Fiorotti, John Allinson, Flora Berisha, Laurent Cocea, Stephanie Croft, Stephanie Fraser, Fabrizio Galliccia, Boris Gorovits, Swati Gupta, Vinita Gupta, Sam Haidar, Charles Hottenstein, Akiko Ishii-Watabe, Darshana Jani, John Kadavil, John Kamerud, Daniel Kramer, Virginia Litwin, Gustavo Mendes Lima Santos, Robert Nelson, Yan Ni, João Pedras-Vasconcelos, Yongchang Qiu, Paul Rhyne, Afshin Safavi, Yoshiro Saito, Natasha Savoie, Kara Scheibner, Eginhard Schick, Patricia Y Siguenza, John Smeraglia, Roland F Staack, Meena Subramanyam, Giane Sumner, Theingi Thway, David Uhlinger, Martin Ullmann, Alessandra Vitaliti, Jan Welink, Chan C Whiting, Li Xue, Rong Zeng
The 2016 10th Workshop on Recent Issues in Bioanalysis (10th WRIB) took place in Orlando, Florida with participation of close to 700 professionals from pharmaceutical/biopharmaceutical companies, biotechnology companies, contract research organizations, and regulatory agencies worldwide. WRIB was once again a weeklong event - A Full Immersion Week of Bioanalysis for PK, Biomarkers and Immunogenicity. As usual, it is specifically designed to facilitate sharing, reviewing, discussing and agreeing on approaches to address the most current issues of interest including both small and large molecules involving LCMS, hybrid LBA/LCMS, and LBA approaches, with the focus on PK, biomarkers and immunogenicity...
December 2016: Bioanalysis
https://www.readbyqxmd.com/read/27855509/2016-white-paper-on-recent-issues-in-bioanalysis-focus-on-biomarker-assay-validation-bav-part-2-hybrid-lba-lcms-and-input-from-regulatory-agencies
#14
An Song, Anita Lee, Fabio Garofolo, Surinder Kaur, Jeff Duggan, Christopher Evans, Joe Palandra, Lorella Di Donato, Keyang Xu, Ronald Bauer, Mark Bustard, Linzhi Chen, Laurent Cocea, Stephanie Croft, Fabrizio Galliccia, Sam Haidar, Nicola Hughes, Akiko Ishii-Watabe, Rafiqul Islam, Barry Jones, John Kadavil, Carsten Krantz, Gustavo Mendes Lima Santos, Timothy Olah, João Pedras-Vasconcelos, Ludovicus Staelens, Yoshiro Saito, Natasha Savoie, Kara Scheibner, Susan Spitz, Nilufer Tampal, Eric Thomas, Stephen Vinter, Jason Wakelin-Smith, Jan Welink, Jianing Zeng, Shaolian Zhou
The 2016 10th Workshop on Recent Issues in Bioanalysis (10(th) WRIB) took place in Orlando, Florida with participation of close to 700 professionals from pharmaceutical/biopharmaceutical companies, biotechnology companies, contract research organizations, and regulatory agencies worldwide. WRIB was once again a 5-day, weeklong event - A Full Immersion Week of Bioanalysis including Biomarkers and Immunogenicity. As usual, it is specifically designed to facilitate sharing, reviewing, discussing and agreeing on approaches to address the most current issues of interest including both small and large molecules involving LCMS, hybrid LBA/LCMS, and LBA approaches, with the focus on biomarkers and immunogenicity...
December 2016: Bioanalysis
https://www.readbyqxmd.com/read/27846931/-ccafu-french-national-guidelines-2016-2018-on-retroperitoneal-sarcoma
#15
T Murez, A Fléchon, L Rocher, P Camparo, N Morel-Journel, P-H Savoie, L Ferretti, P Sèbe, A Méjean, X Durand
INTRODUCTION: The purpose of this article was established by the external genitalia group CCAFU recommandations for diagnosis, treatment and monitoring of retroperitoneal sarcomas, intended for urologists. MATERIAL AND METHODS: The multidisciplinary working group has updated the 2013 guidelines, based on an exhaustive review of the literature on PubMed, valued references, level of evidence, to assign grades of recommendation. RESULTS: From a clinical suspicion evoking a RPS, computed tomography thoraco abdominal and pelvic is the gold standard...
November 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27846930/-ccafu-french-national-guidelines-2016-2018-on-penile-cancer
#16
P Sèbe, L Ferretti, P-H Savoie, N Morel-Journel, A Fléchon, T Murez, L Rocher, P Camparo, A Méjean, X Durand
INTRODUCTION: The aim of this work is to establish guidelines proposed by the external genital organ group of the CCAFU for the diagnosis, treatment and follow-up of penile cancer. MATERIAL AND METHODS: The multidisciplinary working party studied 2013 guidelines exhaustively reviewed the literature, and evaluated references and their level of proof in order to attribute grades of recommandation. RESULTS: The most common histological type is squamous cell carcinoma...
November 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27846929/-ccafu-french-national-guidelines-2016-2018-on-testicular-germ-cell-tumors
#17
X Durand, A Fléchon, T Murez, L Rocher, P Camparo, N Morel-Journel, P-H Savoie, L Ferretti, P Sèbe, A Méjean
INTRODUCTION: The purpose of the oncologic comitee of the french association of urology was to establish guidelines proposed by the external genital organ group, for the diagnosis, treatment and follow-up of the germ cell tumours of the testis. MATERIAL AND METHODS: The multidisciplinary working group studied 2013 guidelines, exhaustively reviewed the literature, and evaluated references and their level of proof in order to attribute grades of recommandation. RESULTS: The initial workup of testicular cancer is based on clinical, laboratory (AFP, total hCG, LDH) and imaging assessment (scrotal ultrasound and chest, abdomen and pelvis computed tomography)...
November 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27842915/age-at-presentation-and-management-of-pediatric-intussusception-a-pediatric-health-information-system-database-study
#18
Kate B Savoie, Fridtjof Thomas, Simonne S Nouer, Max R Langham, Eunice Y Huang
BACKGROUND: Intussusception is uncommon in children older than 3 years, and use of enema reduction in older children is controversial. We sought to determine whether older children are at greater risk of requiring operative intervention and/or having pathology causing lead points, such that enema reduction should not be attempted. METHODS: The Pediatric Health Information System database was reviewed from January 1, 2009-June 30, 2014. Patients were followed for 6 months from initial presentation or until bowel resection occurred...
November 11, 2016: Surgery
https://www.readbyqxmd.com/read/27799834/a-comparison-of-functional-outcomes-in-patients-undergoing-revision-arthroscopic-repair-of-massive-rotator-cuff-tears-with-and-without-arthroscopic-suprascapular-nerve-release
#19
Felix H Savoie, Mark Zunkiewicz, Larry D Field, William H Replogle, Michael J O'Brien
PURPOSE: This study was designed to compare functional outcomes in patients undergoing revision repair of massive rotator cuff tears (retracted medial to the glenoid) with Goutallier Grade 4 atrophy and concomitant release of the suprascapular nerve to a similar group of patients with Grade 3 atrophy undergoing revision rotator cuff repair (RTCR) without nerve release. We hypothesized that patients undergoing nerve release would have more favorable functional outcomes as measured by the Modified University of California at Los Angeles shoulder rating scale (UCLA)...
2016: Open Access Journal of Sports Medicine
https://www.readbyqxmd.com/read/27794616/sequential-c-h-arylation-and-enantioselective-hydrogenation-enables-ideal-asymmetric-entry-to-the-indenopiperidine-core-of-an-11%C3%AE-hsd-1-inhibitor
#20
Xudong Wei, Bo Qu, Xingzhong Zeng, Jolaine Savoie, Keith R Fandrick, Jean-Nicolas Desrosiers, Sergei Tcyrulnikov, Maurice A Marsini, Frederic G Buono, Zhibin Li, Bing-Shiou Yang, Wenjun Tang, Nizar Haddad, Osvaldo Gutierrez, Jun Wang, Heewon Lee, Shengli Ma, Scot Campbell, Jon C Lorenz, Matthias Eckhardt, Frank Himmelsbach, Stefan Peters, Nitinchandra D Patel, Zhulin Tan, Nathan K Yee, Jinhua J Song, Frank Roschangar, Marisa C Kozlowski, Chris H Senanayake
A concise asymmetric synthesis of an 11β-HSD-1 inhibitor has been achieved using inexpensive starting materials with excellent step-economy at low catalyst loadings. The catalytic enantioselective total synthesis of 1 was accomplished in 7 steps and 38% overall yield aided by the development of an innovative, sequential strategy involving Pd-catalyzed pyridinium C-H arylation and Ir-catalyzed asymmetric hydrogenation of the resulting fused tricyclic indenopyridinium salt highlighted by the use of a unique P,N-ligand (MeO-BoQPhos) with 1000 ppm of [Ir(COD)Cl]2...
November 30, 2016: Journal of the American Chemical Society
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