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Neuromodulator

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https://www.readbyqxmd.com/read/28229459/differential-serotonergic-modulation-across-the-main-and-accessory-olfactory-bulbs
#1
Zhenbo Huang, Nicolas Thiebaud, Debra Ann Fadool
Mitral cells (MCs) contained in the main (MOB) and accessory (AOB) olfactory bulb have distinct intrinsic membrane properties but a comparison of the extent of neuromodulation across the two systems is not well explored. Herein, we investigated a widely-distributed CNS modulator, serotonin (5-HT), for its ability to modulate the biophysical properties of MCs across the MOB and AOB, using an in vitro, brain slice approach in postnatal 15-30 day mice. In the MOB, 5-HT elicited three types of responses in 93% of 180 cells tested...
February 22, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28228544/correction-to-an-integrated-modelling-framework-for-neural-circuits-with-multiple-neuromodulators
#2
Alok Joshi, Vahab Youssofzadeh, Vinith Vemana, T M McGinnity, Girijesh Prasad, KongFatt Wong-Lin
No abstract text is available yet for this article.
February 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28227964/cross-entropy-optimization-for-neuromodulation
#3
Harleen K Brar, Yunpeng Pan, Babak Mahmoudi, Evangelos A Theodorou, Harleen K Brar, Yunpeng Pan, Babak Mahmoudi, Evangelos A Theodorou, Yunpeng Pan, Harleen K Brar, Babak Mahmoudi, Evangelos A Theodorou
This study presents a reinforcement learning approach for the optimization of the proportional-integral gains of the feedback controller represented in a computational model of epilepsy. The chaotic oscillator model provides a feedback control systems view of the dynamics of an epileptic brain with an internal feedback controller representative of the natural seizure suppression mechanism within the brain circuitry. Normal and pathological brain activity is simulated in this model by adjusting the feedback gain values of the internal controller...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227957/bidirectional-peripheral-nerve-interface-and-applications
#4
Nitish V Thakor, Qihong Wang, Elliot Greenwald, Nitish V Thakor, Qihong Wang, Elliot Greenwald, Elliot Greenwald, Nitish V Thakor, Qihong Wang
Peripheral nerves, due to their small size and complex innervation to organs and complex physiology, pose particularly significant challenges towards interfacing electrodes and electronics to enable neuromodulation. Here, we present a review of the technology for building such interface, including recording and stimulating electrodes and low power electronics, as well as powering. Of particular advantage to building a miniature implanted device is a "bidirectional" system that both senses from the nerves or surrogate organs and stimulates the nerves to affect the organ function...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227825/real-time-autonomous-bladder-event-classification-and-closed-loop-control-from-single-channel-pressure-data
#5
Robert Karam, Swarup Bhunia, Steve Majerus, Steven W Brose, Margot S Damaser, Dennis Bourbeau, Robert Karam, Swarup Bhunia, Steve Majerus, Steven W Brose, Margot S Damaser, Dennis Bourbeau, Steve Majerus, Margot S Damaser, Robert Karam, Steven W Brose, Dennis Bourbeau, Swarup Bhunia
Urinary incontinence, or the loss of bladder control, is a debilitating condition affecting millions worldwide, which significantly reduces quality of life. Neuromodulation of lower urinary tract nerves can be used to treat sensations of urgency in many subjects, including those with Spinal Cord Injury (SCI). Event driven, or conditional stimulation has been investigated as a possible improvement to the state-of-the-art open-loop stimulation systems available today. However, this requires a robust, adaptive, and noise-tolerant method of classifying bladder function from real-time bladder pressure measurements...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227809/feature-domain-specific-movement-intention-detection-for-stroke-rehabilitation-with-brain-computer-interfaces
#6
J T Hadsund, M B Sorensen, A C Royo, I K Niazi, H Rovsing, C Rovsing, M Jochumsen, J T Hadsund, M B Sorensen, A C Royo, I K Niazi, H Rovsing, C Rovsing, M Jochumsen, H Rovsing, M Jochumsen, M B Sorensen, C Rovsing, A C Royo, I K Niazi, J T Hadsund
Brain-computer interface (BCI) driven electrical stimulation has been proposed for neuromodulation for stroke rehabilitation by pairing intentions to move with somatosensory feedback from electrical stimulation. Movement intentions have been detected in several studies using different techniques, with temporal and spectral features being the most common. A few studies have compared temporal and spectral features, but conflicting results have been reported. In this study, the aim was to investigate if complexity measures can be used for movement intention detection and to compare the detection performance based on features extracted from three different domains (time, frequency and complexity) from single-trial EEG...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227505/powering-and-communication-for-omni-a-distributed-and-modular-closed-loop-neuromodulation-device
#7
Ali Moin, George Alexandrov, Benjamin C Johnson, Igor Izyumin, Fred Burghardt, Kedar Shah, Sat Pannu, Elad Alon, Rikky Muller, Jan M Rabaey, Ali Moin, George Alexandrov, Benjamin C Johnson, Igor Izyumin, Fred Burghardt, Kedar Shah, Sat Pannu, Elad Alon, Rikky Muller, Jan M Rabaey, Fred Burghardt, Beniamin C Johnson, Kedar Shah, Jan M Rabaey, Sat Pannu, Elad Alon, Ali Moin, George Alexandrov
A distributed, modular, intelligent, and efficient neuromodulation device, called OMNI, is presented. It supports closed-loop recording and stimulation on 256 channels from up to 4 physically distinct neuromodulation modules placed in any configuration around the brain, hence offering the capability of addressing neural disorders that are presented at the network level. The specific focus of this paper is the communication and power distribution network that enables the modular and distributed nature of the device...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227500/neuronix-enables-continuous-simultaneous-neural-recording-and-electrical-microstimulation
#8
Zhi Yang, Jian Xu, Anh Tuan Nguyen, Tong Wu, Wenfeng Zhao, Wing-Kin Tam, Zhi Yang, Jian Xu, Anh Tuan Nguyen, Tong Wu, Wenfeng Zhao, Wing-Kin Tam, Zhi Yang, Anh Tuan Nguyen, Jian Xu, Tong Wu, Wenfeng Zhao, Wing-Kin Tam
This paper reports a novel neurotechnology (Neuronix) and its validation through experiments. It is a miniature system-on-chip (SoC) that allows recording with simultaneous electrical microstimulation. This function has not been demonstrated before and enables precise, closed-loop neuromodulation. Neuronix represents recent advancement in brain technology and applies to both animal research and clinical applications.
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227183/a-modular-closed-loop-platform-for-intracranial-stimulation-in-people-with-neurological-disorders
#9
Anish A Sarma, Britni Crocker, Sydney S Cash, Wilson Truccolo, Anish A Sarma, Britni Crocker, Sydney S Cash, Wilson Truccolo, Sydney S Cash, Wilson Truccolo, Anish A Sarma, Britni Crocker
Neuromodulation systems based on electrical stimulation can be used to investigate, probe, and potentially treat a range of neurological disorders. The effects of ongoing neural state and dynamics on stimulation response, and of stimulation parameters on neural state, have broad implications for the development of closed-loop neuro-modulation approaches. We describe the development of a modular, low-latency platform for pre-clinical, closed-loop neuromodulation studies with human participants. We illustrate the uses of the platform in a stimulation case study with a person with epilepsy undergoing neuro-monitoring prior to resective surgery...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227179/influence-of-electrode-configuration-on-the-electric-field-distribution-during-transcutaneous-spinal-direct-current-stimulation-of-the-cervical-spine
#10
Sofia R Fernandes, Ricardo Salvador, Cornelia Wenger, Mamede A de Carvalho, Pedro C Miranda, Sofia R Fernandes, Ricardo Salvador, Cornelia Wenger, Mamede A de Carvalho, Pedro C Miranda, Sofia R Fernandes, Pedro C Miranda, Cornelia Wenger, Ricardo Salvador, Mamede A de Carvalho
Transcutaneous spinal direct current stimulation (tsDCS) is a recent technique with promising neuromodulatory effects on spinal neuronal circuitry. The main objective of the present study was to perform a finite element analysis of the electric field distribution in tsDCS in the cervical spine region, with varying electrode configurations and geometry. A computational model of a human trunk was generated with nine tissue meshes. Three electrode configurations were tested: A) rectangular saline-soaked sponge target and return electrodes placed over C3 and T3 spinous processes, respectively; B1) circular saline-soaked sponge target and return electrodes placed over C7 spinous process and right deltoid muscle, respectively; B2) same configuration as B1, considering circular shaped electrodes with sponge and rubber layers and a small circular connector on the top surface...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226861/improved-electrode-material-for-deep-brain-stimulation
#11
A Petrossians, J J Whalen, J D Weiland, A Petrossians, J J Whalen, J D Weiland, J J Whalen, A Petrossians, J D Weiland
Deep brain stimulation (DBS) devices have been implanted for treatment of basic tremor, Parkinson's disease and dystonia. These devices use electrodes in contact with tissue to deliver electrical pulses to targeted cells, to elicit specific therapeutic responses. In general, the neuromodulation industry has been evolving towards smaller, less invasive electrodes. However, current electrode materials do not support small sizes without severely restricting the stimulus output. Hence, an improved electrode material will benefit present and future DBS systems...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226851/transcranial-focused-ultrasound-for-bold-fmri-signal-modulation-in-humans
#12
Leo Ai, Jerel K Mueller, Andrea Grant, Yigitcan Eryaman, Wynn Legon, Leo Ai, Jerel K Mueller, Andrea Grant, Yigitcan Eryaman, Wynn Legon, Andrea Grant, Wynn Legon, Yigitcan Eryaman, Leo Ai, Jerel K Mueller
Transcranial focused ultrasound (tFUS) is an emerging form of non-surgical human neuromodulation that confers advantages over existing electro and electromagnetic technologies by providing a superior spatial resolution on the millimeter scale as well as the capability to target sub-cortical structures non-invasively. An examination of the pairing of tFUS and blood oxygen level dependent (BOLD) functional MRI (fMRI) in humans is presented here.
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226850/the-effect-of-inter-electrode-distance-on-the-electric-field-distribution-during-transcutaneous-lumbar-spinal-cord-direct-current-stimulation
#13
Rui Bastos, Sofia R Fernandes, Ricardo Salvador, Cornelia Wenger, Mamede A de Carvalho, Pedro C Miranda, Rui Bastos, Sofia R Fernandes, Ricardo Salvador, Cornelia Wenger, Mamede A de Carvalho, Pedro C Miranda, Pedro C Miranda, Rui Bastos, Cornelia Wenger, Ricardo Salvador, Mamede A de Carvalho, Sofia R Fernandes
Previous studies have indicated potential neuromodulation of the spinal circuitry by transcutaneous spinal direct current stimulation (tsDCS), such as changes in motor unit recruitment, shortening of the peripheral silent period and interference with supraspinal input to lower motor neurons. All of these effects were dependent on the polarity of the electrodes. The present study investigates how the distance between the electrodes during tsDCS influences the electric field's (E-field) spatial distribution in the lumbar and sacral spinal cord (SC)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226403/the-effect-of-peripheral-neuromodulation-on-pain-from-the-sacroiliac-joint-a-retrospective-cohort-study
#14
Teodor Goroszeniuk, Ashish Shetty, Rajesh Munglani, Dominic Hegarty, Arun Bhaskar
We report here a retrospective review of the longer-term results of peripheral neuromodulation in 12 patients with significant chronic sacroiliac joint pain who had previously failed multiple conservative and interventional pain therapies. To allow for the assessment of meaningful longer-term outcome, implants for all 12 patients had been in place for a minimum of 18 months to a maximum of 36 months prior to the formal review. Compared to the preimplantation baseline, the longer-term follow-up revealed a significant and sustained reduction in visual analog scale pain scores from 8...
February 22, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28224396/sacral-neuromodulation-implant-infection-risk-factors-and-prevention
#15
REVIEW
Calvin Lee, Javier Pizarro-Berdichevsky, Marisa M Clifton, Sandip P Vasavada
Device infection is one of the most common complications of sacral nerve stimulator placement and occurs in approximately 3-10% of cases. Infection is a serious complication, as it often requires complete explantation of the device. Not much is known regarding risk factors for and methods of preventing infection in sacral nerve stimulation. Multiple risk factors have been linked to device infection including prolonged percutaneous testing and choice of preoperative antibiotic. Methods of infection prevention have also been studied recently, including antibiotic-impregnated collage and type of skin preparation...
February 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28222543/anodal-cerebellar-tdcs-modulates-lower-extremity-pain-perception
#16
Manuel Pereira, Basil Rafiq, Einul Chowdhury, Jacqueline Babayev, HyunJi Boo, Rowan Metwaly, Sandilya Priam, Eileen Chusid, Fortunato Battaglia
BACKGROUND: Previous studies have investigated the use of transcranial direct current stimulation (tDCS) for pain management. The studies investigating therapeutic neuromodulation with tDCS for lower extremity pain are scarce and inconclusive. OBJECTIVE: The aim of the present study was to analyze the effects of cerebellar tDCS on lower extremity sensory and pain thresholds in healthy volunteers. METHODS: This was a single-blind crossover repeated-measure study...
January 31, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28222198/algorithmic-design-of-a-noise-resistant-and-efficient-closed-loop-deep-brain-stimulation-system-a-computational-approach
#17
Sofia D Karamintziou, Ana Luísa Custódio, Brigitte Piallat, Mircea Polosan, Stéphan Chabardès, Pantelis G Stathis, George A Tagaris, Damianos E Sakas, Georgia E Polychronaki, George L Tsirogiannis, Olivier David, Konstantina S Nikita
Advances in the field of closed-loop neuromodulation call for analysis and modeling approaches capable of confronting challenges related to the complex neuronal response to stimulation and the presence of strong internal and measurement noise in neural recordings. Here we elaborate on the algorithmic aspects of a noise-resistant closed-loop subthalamic nucleus deep brain stimulation system for advanced Parkinson's disease and treatment-refractory obsessive-compulsive disorder, ensuring remarkable performance in terms of both efficiency and selectivity of stimulation, as well as in terms of computational speed...
2017: PloS One
https://www.readbyqxmd.com/read/28219848/bioelectronic-neuromodulation-of-the-paravertebral-cardiac-efferent-sympathetic-outflow-and-its-effect-on-ventricular-electrical-indices
#18
Una Buckley, Ray W Chui, Pradeep S Rajendran, Tina Vrabec, Kalyanam Shivkumar, Jeffrey L Ardell
INTRODUCTION: Neuromodulation of the paravertebral ganglia, using symmetric voltage controlled kilohertz frequency alternating current (KHFAC), has the potential to be a reversible alternative to surgical intervention in patients with refractory ventricular arrhythmias. KHFAC creates scalable focal inhibition of action potential conduction. OBJECTIVE: To evaluate the efficacy of KHFAC, when applied to T1-T2 paravertebral chain, to mitigate sympathetic outflow to the heart...
February 17, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28218218/effects-of-appropriate-prolonged-sacral-neuromodulation-testing-in-improving-implantation-rate-of-a-permanent-implantable-pulse-generator-in-patients-with-refractory-lower-urinary-tract-dysfunctions-in-mainland-china
#19
Peng Zhang, Jian-Zhong Zhang, Li-Yang Wu, Xiao-Dong Zhang
BACKGROUND: Sacral neuromodulation (SNM) has become an effective method for treating lower urinary tract voiding dysfunction during the past 20 years. Because of the expensive cost, the number of implantable pulse generator (IPG) implantations per year in China is far lower than that in Western developed countries since 2012. This study was to summarize the effects of the appropriate prolonged SNM testing time in improving the implantation rate of a permanent IPG in patients with refractory lower urinary tract symptoms (LUTS) in mainland China...
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28216388/advances-in-mechanisms-and-management-of-chronic-cough-the-ninth-london-international-cough-symposium-2016
#20
REVIEW
Kian Fan Chung
At the Ninth London International Cough Symposium held in June 2016, advances in chronic cough were presented. Chronic cough has been labelled as a cough hypersensitivity syndrome (CHS) with neuroinflammatory mechanisms likely to be the underlying mechanisms. The concept is that there is a stage of peripheral sensitisation induced by inflammatory factors setting up the scene for a central component that can be visualised by functional magnetic resonance imaging. There has also been progress in assessing CHS patients in the clinic in terms of measuring cough, with an increasing interest in assessing different types of cough associated with respiratory diseases such as asthma, COPD, bronchiectasis and pulmonary fibrosis...
February 16, 2017: Pulmonary Pharmacology & Therapeutics
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