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Neonatal Hypernatremia

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https://www.readbyqxmd.com/read/27826706/clinical-associations-of-early-dysnatremias-in-critically-ill-neonates-and-infants-undergoing-cardiac-surgery
#1
Jon Kaufman, Daniel Phadke, Suhong Tong, Jennifer Eshelman, Sarah Newman, Christopher Ruzas, Eduardo M da Cruz, Suzanne Osorio
: Dysnatremias (DN) are common electrolyte disturbances in cardiac critical illness and are known risk factors for adverse outcomes in certain populations. Little information exists on DN in children with cardiac disease admitted to the cardiac intensive care unit (CICU) after undergoing cardiac surgery, either corrective or palliative. The aim was to determine the incidence and adverse outcomes associated with DN in neonates and infants undergoing cardiac surgery. Retrospective cohort and single center study performed at Children's Hospital Colorado from May 2013 to May 2014, in children under 1 year old admitted to the CICU after undergoing surgery for congenital or acquired cardiac disease...
November 8, 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/27183555/a-rare-cause-of-retinal-artery-occlusion-in-severe-hypernatremic-dehydration-in-newborns
#2
Pinar Altiaylik Ozer, Emrah Utku Kabatas, Bengi Ece Kurtul, Dilek Dilli, Aysegul Zenciroglu, Nurullah Okumus
Neonatal hypernatremia is an important electrolyte disorder that may have serious complications. It may be a rare and underdiagnosed cause of venous and arterial thrombosis, leading to severe brain damage by cerebral edema and intracranial hemorrhage. Here, the authors present a case of bilateral central retinal artery occlusion in a newborn with severe hypernatremic dehydration who is found to be normal in terms of other causes of retinal arterial thromboembolization. [Ophthalmic Surg Lasers Imaging Retina...
May 1, 2016: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/26643826/a-prospective-study-on-exchange-transfusion-in-neonatal-unconjugated-hyperbilirubinemia-in-a-tertiary-care-hospital-nepal
#3
T Malla, S Singh, P Poudyal, B Sathian, G Bk, K K Malla
BACKGROUND: An exchange transfusion involves replacing patient's blood with donor blood in order to remove abnormal blood components and circulating toxins while maintaining adequate circulating blood volume. OBJECTIVE: To observe the incidence, causes of jaundice requiring Exchange and any adverse event of exchange transfusion in newborns with unconjugated hyperbilirubinemia. METHOD: Prospective study undertaken at Neonatal Intensive Care Unit (NICU) of Manipal Teaching Hospital, Pokhara, Nepal from March 2014 to April 2015...
April 2015: Kathmandu University Medical Journal (KUMJ)
https://www.readbyqxmd.com/read/26613228/idiopathic-central-diabetes-insipidus-presenting-in-a-very-low-birth-weight-infant-successfully-managed-with-lyophilized-sublingual-desmopressin
#4
Deniz Hanta, Birgin Törer, Fatih Temiz, Hasan Kılıçdağ, Mahmut Gökçe, Özlem Erdoğan
Neonatal central diabetes insipidus (DI) is an extremely rare disorder that can cause severe morbidity and mortality. We have reported a very low birth weight infant with idiopathic central DI presenting in the first month of life who was successfully treated with sublingual desmopressin therapy. In this report, we emphasize that central DI should be kept in mind in an infant with unexplained hypernatremia and polyuria. Timely diagnosis and treatment with lyophilized desmopressin may prevent severe morbidity and mortality...
January 2015: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/26588450/central-diabetes-insipidus-in-infancy-with-or-without-hypothalamic-adipsic-hypernatremia-syndrome-early-identification-and-outcome
#5
Adel Djermane, Monique Elmaleh, Dominique Simon, Amélie Poidvin, Jean-Claude Carel, Juliane Léger
CONTEXT: Neonatal central diabetes insipidus (CDI) with or without adipsia is a very rare complication of various complex hypothalamic disorders. It is associated with greater morbidity and a high risk of developing both hypernatremia and hyponatremia, due to the condition itself or secondary to treatment with vasopressin analogs or fluid administration. Its outcomes have yet to be evaluated. OBJECTIVE: To investigate the clinical outcomes of patients with neonatal-onset CDI or adipsic CDI with hypernatremia...
February 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26530059/breastfeeding-associated-hypernatremia-a-systematic-review-of-the-literature
#6
REVIEW
Camilla Lavagno, Pietro Camozzi, Samuele Renzi, Sebastiano A G Lava, Giacomo D Simonetti, Mario G Bianchetti, Gregorio P Milani
There are increasing reports on hypernatremia, a potentially devastating condition, in exclusively breastfed newborn infants. Our purposes were to describe the clinical features of the condition and identify the risk factors for it. We performed a review of the existing literature in the National Library of Medicine database and in the search engine Google Scholar. A total of 115 reports were included in the final analysis. Breastfeeding-associated neonatal hypernatremia was recognized in infants who were ≤ 21 days of age and had ≥ 10% weight loss of birth weight...
February 2016: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/26508187/effects-of-tolvaptan-on-congestive-heart-failure-complicated-with-chylothorax-in-a-neonate
#7
Nikiko Sato, Tokio Sugiura, Rika Nagasaki, Kazutaka Suzuki, Koichi Ito, Takenori Kato, Sachiko Inukai, Shinji Saitoh
Tolvaptan is an oral vasopressin type 2 receptor antagonist that can be used for heart failure patients with hyponatremia or symptomatic congestion. Although the effects of tolvaptan in adults have been well documented, only limited information is available in children. The case of a neonate with congestive heart failure complicated with chylothorax after palliative surgery for transposition of the great arteries treated with tolvaptan is reported. Slow up-titration to 0.1 mg/kg successfully increased urine output and improved refractory congestive heart failure without hypernatremia...
October 2015: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/26229701/netherton-syndrome-in-a-neonate-with-possible-growth-hormone-deficiency-and-transient-hyperaldosteronism
#8
Chatziioannidis Ilias, Babatseva Evgenia, Patsatsi Aikaterini, Galli-Tsinopoulou Asimina, Sarri Constantina, Lithoxopoulou Maria, Mitsiakos George, Karagianni Paraskevi, Tsakalidis Christos, Mamuris Zissis, Nikolaidis Nikolaos
Netherton syndrome, a rare autosomal recessive genetic disorder, is classified as an ichthyosiform syndrome. In this report we present the case of a neonate with erythroderma shortly after birth, accompanied by severe hypernatremia, recurrent infections, transient hyperaldosteronism, and signs of growth hormone (GH) deficiency. DNA molecular analysis in the SPINK5 gene revealed heterozygosity in our index patient for 238insG and 2468delA frameshift mutations in exons 4 and 26, respectively, in the maternal allele and 1431-12G>A splice-site mutation in intron 15 in the paternal allele as well as the missense variation E420K in homozygous state...
2015: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/25988555/electrolyte-and-mineral-homeostasis-after-optimizing-early-macronutrient-intakes-in-vlbw-infants-on-parenteral-nutrition
#9
Thibault Senterre, Ibrahim Abu Zahirah, Catherine Pieltain, Virginie de Halleux, Jacques Rigo
OBJECTIVES: The aim of the present study was to evaluate electrolyte and mineral homeostasis in very-low-birth-weight (VLBW) infants who received high protein and energy intakes with a unique standardized parenteral nutrition solution containing electrolytes and minerals from birth onward. METHODS: Prospective cohort study in 102 infants with birth weight <1250 g. The evolution of plasma biochemical parameters was described during the first 2 weeks of life. RESULTS: During the first 3 days of life, mean parenteral intakes were 51 ± 8 kcal · kg · day with 2...
October 2015: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/25745483/desmopressin-lyophilisate-for-the-treatment-of-central-diabetes-insipidus-first-experience-in-very-young-infants
#10
Kathleen De Waele, Martine Cools, Ann De Guchtenaere, Johan Van de Walle, Ann Raes, Sara Van Aken, Kris De Coen, Piet Vanhaesebrouck, Jean De Schepper
INTRODUCTION: In neonates and small infants, early diagnosis of central diabetes insipidus (CDI) and treatment with desmopressin in low doses (avoiding severe hypo- or hypernatremia) are important to prevent associated high morbidity and mortality in this particular age group. CASE PRESENTATION: We described pharmacokinetic and pharmacodynamic results of the use of recently launched oral desmopressin lyophilisate (Minirin Melt®) in two infants with CDI, diagnosed at the age of 12 and 62 days, respectively...
October 2014: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/25449762/-vasopressin-v2-receptor-related-pathologies-congenital-nephrogenic-diabetes-insipidus-and-nephrogenic-syndrome-of-inappropiate-antidiuresis
#11
Denis Morin
Congenital nephrogenic diabetes insipidus is a rare hereditary disease with mainly an X-linked inheritance (90% of the cases) but there are also autosomal recessive and dominant forms. Congenital nephrogenic diabetes insipidus is characterized by a resistance of the renal collecting duct to the action of the arginine vasopressin hormone responsible for the inability of the kidney to concentrate urine. The X-linked form is due to inactivating mutations of the vasopressin 2 receptor gene leading to a loss of function of the mutated receptors...
December 2014: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/25271879/central-diabetes-insipidus-alert-for-dehydration-in-very-low-birth-weight-infants-during-the-neonatal-period-a-case-report
#12
Maria Lúcia Silveira Ferlin, Débora Simone Sales, Fábia Pereira Martins Celini, Carlos Eduardo Martinelli Junior
CONTEXT: Central diabetes insipidus (CDI) is a rare cause of hypernatremia during the neonatal period. The diagnosis is particularly difficult in very low birth weight (VLBW) newborns. CASE REPORT: We report on a preterm newborn who presented CDI soon after birth. On the third day of life, signs of dehydration were present despite normal fluid supply. The diuresis rate was 4.4 ml/kg/h. Although the fluid supply was then increased, the dehydration continued, with hypernatremia, normal glycemia, diuresis of 7...
February 2015: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/25255707/congenital-central-diabetes-insipidus-and-optic-atrophy-in-a-wolfram-newborn-is-there-a-role-for-wfs1-gene-in-neurodevelopment
#13
Stefano Ghirardello, Elisa Dusi, Bianca Castiglione, Monica Fumagalli, Fabio Mosca
BACKGROUND: Wolfram syndrome (WS) is an autosomal recessive neurodegenerative disorder characterized by diabetes mellitus (DM), optic atrophy (OA), central diabetes insipidus (CDI) and deafness (D). The phenotype of the disease has been associated with several mutations in the WFS1 gene, a nuclear gene localized on chromosome 4. Since the discovery of the association between WFS1 gene and Wolfram syndrome, more than 150 mutations have been identified in WS patients. We previously described the first case of perinatal onset of Wolfram syndrome newborn carrying a segmental uniparental heterodysomy affecting the short arm of chromosome 4 responsible for a significant reduction in wolframin expression...
2014: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/25002871/efficacy-of-hydrochlorothiazide-and-low-renal-solute-feed-in-neonatal-central-diabetes-insipidus-with-transition-to-oral-desmopressin-in-early-infancy
#14
Mary B Abraham, Shripada Rao, Glynis Price, Catherine S Choong
BACKGROUND: The treatment of central diabetes insipidus (DI) with desmopressin in the neonatal period is challenging because of the significant risk of hyponatremia with this agent. The fixed anti-diuresis action of desmopressin and the obligate high fluid intake with milk feeds lead to considerable risk of water intoxication and hyponatremia. To reduce this risk, thiazide diuretics, part of the treatment of nephrogenic DI, were used in conjunction with low renal solute feed and were effective in a single case series of neonatal central DI...
2014: International Journal of Pediatric Endocrinology
https://www.readbyqxmd.com/read/24854529/management-of-central-diabetes-insipidus-with-oral-desmopressin-lyophilisate-in-infants
#15
Hüseyin Anıl Korkmaz, Korcan Demir, Fatma Kaya Kılıç, Demet Terek, Sertaç Arslanoğlu, Ceyhun Dizdarer, Behzat Ozkan
AIM: To assess the efficiency of oral desmopressin lyophilisate (ODL) in neonatal central diabetes insipidus (CDI). METHODS: The characteristics of four newborns with CDI treated with ODL were evaluated. RESULTS: Four newborns with polyuria and hypernatremia were included [male, 2 (50%); mean postnatal age, 19±17 days]. At the time of hypernatremia, the mean serum and urine osmolality values were 310±16 and 179±48 mOsm/kg, respectively...
September 2014: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/24706463/non-neurological-steroid-related-adverse-events-in-very-low-birth-weight-infants-a-prospective-audit
#16
S B Röhr, H Sauer, S Gottschling, H Abdul-Khaliq, L Gortner, H Nunold, S Gräber, S Meyer
BACKGROUND AND STUDY PURPOSE: To assess the incidence of cardiac and metabolic adverse events in very low birth weight (VLBW) infants receiving systematic steroids. PATIENTS AND METHODS: Prospective single centre audit in VLBW infants (<1,500 g) at the neonatal intensive care unit at the University Children's Hospital of Saarland, Germany. RESULTS: A total of 72 VLBW infants (38 female) were included in this report (mean birth weight: 967 ± 338 g; range: 320-1490 g)...
2014: Swiss Medical Weekly
https://www.readbyqxmd.com/read/24630509/congenital-glucose-galactose-malabsorption-a-descriptive-study-of-clinical-characteristics-and-outcome-from-western-saudi-arabia
#17
Omar I Saadah, Sharifa A Alghamdi, Haifa H Sindi, Huda Alhunaitti, Yagoub Y Bin-Taleb, Bakr H Alhussaini
BACKGROUND AND STUDY AIMS: Congenital glucose galactose malabsorption (CGGM) is a rare autosomal recessive disorder caused by a defect in the sodium-coupled transport of glucose and galactose across the intestinal brush border presenting with neonatal diarrhoea. The aim of this study was to report the clinical and laboratory characteristics of patients with CGGM from the Western Saudi Arabia. PATIENTS AND METHODS: This is a retrospective review of CGGM patients in three major hospitals in the city of Jeddah, Saudi Arabia, namely King Abdulaziz University Hospital, King Faisal Specialist Hospital and Research Centre, and Maternity Children Hospital in the period between November 2001 and October 2011...
March 2014: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/24505569/could-neonatal-hypernatremia-dehydration-influence-hearing-status
#18
Hassan Boskabadi, Farnaz Anvarifar, Navid Nourizadeh
INTRODUCTION: Neonatal hypernatremia dehydration (NHD) is a dangerous condition in neonates, which is accompanied by acute complications (renal failure, cerebral edema, and cerebral hemorrhage) and chronic complications (developmental delay). Children begin learning language from birth, and hearing impairment interferes with this process. We assessed the hearing status of infants with hypernatremia dehydration. MATERIALS AND METHODS: In a case-control study in 110 infants presenting at the Ghaem Hospital (Mashhad, Iran) between 2007 and 2011, we examined the incidence of hearing impairment in infants suffering from hypernatremia dehydration (serum sodium >150 mEq/L) in comparison with infants with normal sodium level (serum sodium ≤150 mEq/L)...
January 2014: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/23991143/excess-maternal-salt-intake-produces-sex-specific-hypertension-in-offspring-putative-roles-for-kidney-and-gastrointestinal-sodium-handling
#19
Clint Gray, Emad A Al-Dujaili, Alexander J Sparrow, Sheila M Gardiner, Jim Craigon, Simon J M Welham, David S Gardner
Hypertension is common and contributes, via cardiovascular disease, towards a large proportion of adult deaths in the Western World. High salt intake leads to high blood pressure, even when occurring prior to birth - a mechanism purported to reside in altered kidney development and later function. Using a combination of in vitro and in vivo approaches we tested whether increased maternal salt intake influences fetal kidney development to render the adult individual more susceptible to salt retention and hypertension...
2013: PloS One
https://www.readbyqxmd.com/read/23919742/prognostic-value-of-amplitude-integrated-electroencephalography-in-neonates-with-hypernatremic-dehydration
#20
Kadir Şerafettin Tekgunduz, Ibrahim Caner, Zeynep Eras, Ayhan Taştekin, Huseyin Tan, Nurdan Dinlen
OBJECTIVES: Hypernatremic dehydration in neonates is a condition that develops due to inadequate fluid intake and it may lead to cerebral damage. We aimed to determine whether there was an association between serum sodium levels on admission and aEEG patterns and prognosis, as well as any association between aEEG findings and survival rates and long-term prognosis. METHOD: The present study included all term infants hospitalized for hypernatremic dehydration in between January 2010 and May 2011...
May 2014: Journal of Maternal-fetal & Neonatal Medicine
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