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Neonatal Hypernatremia

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https://www.readbyqxmd.com/read/28817693/clinical-signs-profound-acidemia-hypoglycemia-and-hypernatremia-are-predictive-of-mortality-in-1-400-critically-ill-neonatal-calves-with-diarrhea
#1
Florian M Trefz, Ingrid Lorenz, Annette Lorch, Peter D Constable
Profound acidemia impairs cellular and organ function and consequently should be associated with an increased risk of mortality in critically ill humans and animals. Neonatal diarrhea in calves can result in potentially serious metabolic derangements including profound acidemia due to strong ion (metabolic) acidosis, hyper-D-lactatemia, hyper-L-lactatemia, azotemia, hypoglycemia, hyperkalemia and hyponatremia. The aim of this retrospective study was to assess the prognostic relevance of clinical and laboratory findings in 1,400 critically ill neonatal calves with diarrhea admitted to a veterinary teaching hospital...
2017: PloS One
https://www.readbyqxmd.com/read/28553778/pulmonary-hypertension-and-right-heart-failure-due-to-severe-hypernatremic-dehydration
#2
Saurabh Chiwane, Tageldin M Ahmed, Christian P Bauerfeld, Monika Chauhan
INTRODUCTION: Neonates are at risk of developing hypernatremic dehydration and its associated complications, such as stroke, dural sinus thrombosis and renal vein thrombosis. Pulmonary hypertension has not been described as a complication of hypernatremia. CASE REPORT: We report a case of a seven-day-old neonate with severe hypernatremic dehydration who went on to develop pulmonary hypertension and right heart failure needing extracorporeal membrane oxygenation (ECMO)...
July 2017: Perfusion
https://www.readbyqxmd.com/read/28331868/a-novel-practical-equation-for-treatment-of-emergent-hypernatremia-and-dehydration-phase-in-infants
#3
Saba Ghaffary, Azadeh Moghaddas, Mehrnoush Dianatkhah
Serum sodium (Na) concentration more than 145 mmol/L is defined as hypernatremia. Hypernatremia carries an acute morbidity and mortality, especially in neonates and infants. Rapid correction of hypernatremia leads to severe cerebral damages, and seizure is the most common neurological complication of hypernatremia. Selection and calculation of an appropriate fluid and its amount is one of the tremendous challenges. It is important to choose the correct amount of suitable fluid and adjust rehydration rate. In this study, we have suggested practical equation to determine the amount of fluid that should be administered to the neonates and infants with hypernatremia...
January 2017: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/28328233/long-term-neurodevelopmental-outcome-of-neonates-with-hypernatremic-dehydration
#4
Hassan Boskabadi, Javad Akhondian, Maliheh Afarideh, Gholamali Maamouri, Sepideh Bagheri, Seyyed Mostafa Parizadeh, Majid Ghayour Mobarhan, Shabnam Mohammadi, Gordon A A Frens
BACKGROUND: Neonatal hypernatremic dehydration (NHD) is a dangerous condition that can lead to severe weight loss, renal impairment, and central nervous system complications. We aimed to evaluate the consequences of NHD in infants in their second year of life. MATERIALS AND METHODS: This was a prospective case-control study in Ghaem hospital, Mashhad, Iran. Sixty-five healthy breastfed neonates (serum sodium concentration <150 mmol/L) and 65 hypernatremic (serum sodium concentration ≥150 mmol/L) neonates were followed up from 2008 to 2011...
April 2017: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/28197048/hypernatremia-in-the-neonate-neonatal-hypernatremia-and-hypernatremic-dehydration-in-neonates-receiving-exclusive-breastfeeding
#5
Nilofer Salim Mujawar, Archana Nirmal Jaiswal
AIMS AND OBJECTIVES: Evaluation of neonatal hypernatremia and hypernatremic dehydration in neonates receiving exclusive breastfeeding. INTRODUCTION: Neonatal hypernatremia is a serious condition in the newborn period. We present infants with hypernatremic dehydration due to breast milk (BM) hypernatremia. Hypernatremic dehydration in breast-fed newborns is usually secondary to insufficient lactation. We present the neonatal hypernatremia and hypernatremic dehydration encountered between January and December, 2012, its causes and treatment...
January 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/27826706/clinical-associations-of-early-dysnatremias-in-critically-ill-neonates-and-infants-undergoing-cardiac-surgery
#6
Jon Kaufman, Daniel Phadke, Suhong Tong, Jennifer Eshelman, Sarah Newman, Christopher Ruzas, Eduardo M da Cruz, Suzanne Osorio
Dysnatremias (DN) are common electrolyte disturbances in cardiac critical illness and are known risk factors for adverse outcomes in certain populations. Little information exists on DN in children with cardiac disease admitted to the cardiac intensive care unit (CICU) after undergoing cardiac surgery, either corrective or palliative. The aim was to determine the incidence and adverse outcomes associated with DN in neonates and infants undergoing cardiac surgery. Retrospective cohort and single center study performed at Children's Hospital Colorado from May 2013 to May 2014, in children under 1 year old admitted to the CICU after undergoing surgery for congenital or acquired cardiac disease...
January 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/27183555/a-rare-cause-of-retinal-artery-occlusion-in-severe-hypernatremic-dehydration-in-newborns
#7
Pinar Altiaylik Ozer, Emrah Utku Kabatas, Bengi Ece Kurtul, Dilek Dilli, Aysegul Zenciroglu, Nurullah Okumus
Neonatal hypernatremia is an important electrolyte disorder that may have serious complications. It may be a rare and underdiagnosed cause of venous and arterial thrombosis, leading to severe brain damage by cerebral edema and intracranial hemorrhage. Here, the authors present a case of bilateral central retinal artery occlusion in a newborn with severe hypernatremic dehydration who is found to be normal in terms of other causes of retinal arterial thromboembolization. [Ophthalmic Surg Lasers Imaging Retina...
May 1, 2016: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/26643826/a-prospective-study-on-exchange-transfusion-in-neonatal-unconjugated-hyperbilirubinemia-in-a-tertiary-care-hospital-nepal
#8
T Malla, S Singh, P Poudyal, B Sathian, G Bk, K K Malla
BACKGROUND: An exchange transfusion involves replacing patient's blood with donor blood in order to remove abnormal blood components and circulating toxins while maintaining adequate circulating blood volume. OBJECTIVE: To observe the incidence, causes of jaundice requiring Exchange and any adverse event of exchange transfusion in newborns with unconjugated hyperbilirubinemia. METHOD: Prospective study undertaken at Neonatal Intensive Care Unit (NICU) of Manipal Teaching Hospital, Pokhara, Nepal from March 2014 to April 2015...
April 2015: Kathmandu University Medical Journal (KUMJ)
https://www.readbyqxmd.com/read/26613228/idiopathic-central-diabetes-insipidus-presenting-in-a-very-low-birth-weight-infant-successfully-managed-with-lyophilized-sublingual-desmopressin
#9
Deniz Hanta, Birgin Törer, Fatih Temiz, Hasan Kılıçdağ, Mahmut Gökçe, Özlem Erdoğan
Neonatal central diabetes insipidus (DI) is an extremely rare disorder that can cause severe morbidity and mortality. We have reported a very low birth weight infant with idiopathic central DI presenting in the first month of life who was successfully treated with sublingual desmopressin therapy. In this report, we emphasize that central DI should be kept in mind in an infant with unexplained hypernatremia and polyuria. Timely diagnosis and treatment with lyophilized desmopressin may prevent severe morbidity and mortality...
January 2015: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/26588450/central-diabetes-insipidus-in-infancy-with-or-without-hypothalamic-adipsic-hypernatremia-syndrome-early-identification-and-outcome
#10
Adel Djermane, Monique Elmaleh, Dominique Simon, Amélie Poidvin, Jean-Claude Carel, Juliane Léger
CONTEXT: Neonatal central diabetes insipidus (CDI) with or without adipsia is a very rare complication of various complex hypothalamic disorders. It is associated with greater morbidity and a high risk of developing both hypernatremia and hyponatremia, due to the condition itself or secondary to treatment with vasopressin analogs or fluid administration. Its outcomes have yet to be evaluated. OBJECTIVE: To investigate the clinical outcomes of patients with neonatal-onset CDI or adipsic CDI with hypernatremia...
February 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26530059/breastfeeding-associated-hypernatremia-a-systematic-review-of-the-literature
#11
REVIEW
Camilla Lavagno, Pietro Camozzi, Samuele Renzi, Sebastiano A G Lava, Giacomo D Simonetti, Mario G Bianchetti, Gregorio P Milani
There are increasing reports on hypernatremia, a potentially devastating condition, in exclusively breastfed newborn infants. Our purposes were to describe the clinical features of the condition and identify the risk factors for it. We performed a review of the existing literature in the National Library of Medicine database and in the search engine Google Scholar. A total of 115 reports were included in the final analysis. Breastfeeding-associated neonatal hypernatremia was recognized in infants who were ≤ 21 days of age and had ≥ 10% weight loss of birth weight...
February 2016: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/26508187/effects-of-tolvaptan-on-congestive-heart-failure-complicated-with-chylothorax-in-a-neonate
#12
Nikiko Sato, Tokio Sugiura, Rika Nagasaki, Kazutaka Suzuki, Koichi Ito, Takenori Kato, Sachiko Inukai, Shinji Saitoh
Tolvaptan is an oral vasopressin type 2 receptor antagonist that can be used for heart failure patients with hyponatremia or symptomatic congestion. Although the effects of tolvaptan in adults have been well documented, only limited information is available in children. The case of a neonate with congestive heart failure complicated with chylothorax after palliative surgery for transposition of the great arteries treated with tolvaptan is reported. Slow up-titration to 0.1 mg/kg successfully increased urine output and improved refractory congestive heart failure without hypernatremia...
October 2015: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/26229701/netherton-syndrome-in-a-neonate-with-possible-growth-hormone-deficiency-and-transient-hyperaldosteronism
#13
Chatziioannidis Ilias, Babatseva Evgenia, Patsatsi Aikaterini, Galli-Tsinopoulou Asimina, Sarri Constantina, Lithoxopoulou Maria, Mitsiakos George, Karagianni Paraskevi, Tsakalidis Christos, Mamuris Zissis, Nikolaidis Nikolaos
Netherton syndrome, a rare autosomal recessive genetic disorder, is classified as an ichthyosiform syndrome. In this report we present the case of a neonate with erythroderma shortly after birth, accompanied by severe hypernatremia, recurrent infections, transient hyperaldosteronism, and signs of growth hormone (GH) deficiency. DNA molecular analysis in the SPINK5 gene revealed heterozygosity in our index patient for 238insG and 2468delA frameshift mutations in exons 4 and 26, respectively, in the maternal allele and 1431-12G>A splice-site mutation in intron 15 in the paternal allele as well as the missense variation E420K in homozygous state...
2015: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/25988555/electrolyte-and-mineral-homeostasis-after-optimizing-early-macronutrient-intakes-in-vlbw-infants-on-parenteral-nutrition
#14
Thibault Senterre, Ibrahim Abu Zahirah, Catherine Pieltain, Virginie de Halleux, Jacques Rigo
OBJECTIVES: The aim of the present study was to evaluate electrolyte and mineral homeostasis in very-low-birth-weight (VLBW) infants who received high protein and energy intakes with a unique standardized parenteral nutrition solution containing electrolytes and minerals from birth onward. METHODS: Prospective cohort study in 102 infants with birth weight <1250 g. The evolution of plasma biochemical parameters was described during the first 2 weeks of life. RESULTS: During the first 3 days of life, mean parenteral intakes were 51 ± 8 kcal · kg · day with 2...
October 2015: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/25745483/desmopressin-lyophilisate-for-the-treatment-of-central-diabetes-insipidus-first-experience-in-very-young-infants
#15
Kathleen De Waele, Martine Cools, Ann De Guchtenaere, Johan Van de Walle, Ann Raes, Sara Van Aken, Kris De Coen, Piet Vanhaesebrouck, Jean De Schepper
INTRODUCTION: In neonates and small infants, early diagnosis of central diabetes insipidus (CDI) and treatment with desmopressin in low doses (avoiding severe hypo- or hypernatremia) are important to prevent associated high morbidity and mortality in this particular age group. CASE PRESENTATION: We described pharmacokinetic and pharmacodynamic results of the use of recently launched oral desmopressin lyophilisate (Minirin Melt®) in two infants with CDI, diagnosed at the age of 12 and 62 days, respectively...
October 2014: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/25449762/-vasopressin-v2-receptor-related-pathologies-congenital-nephrogenic-diabetes-insipidus-and-nephrogenic-syndrome-of-inappropiate-antidiuresis
#16
REVIEW
Denis Morin
Congenital nephrogenic diabetes insipidus is a rare hereditary disease with mainly an X-linked inheritance (90% of the cases) but there are also autosomal recessive and dominant forms. Congenital nephrogenic diabetes insipidus is characterized by a resistance of the renal collecting duct to the action of the arginine vasopressin hormone responsible for the inability of the kidney to concentrate urine. The X-linked form is due to inactivating mutations of the vasopressin 2 receptor gene leading to a loss of function of the mutated receptors...
December 2014: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/25271879/central-diabetes-insipidus-alert-for-dehydration-in-very-low-birth-weight-infants-during-the-neonatal-period-a-case-report
#17
Maria Lúcia Silveira Ferlin, Débora Simone Sales, Fábia Pereira Martins Celini, Carlos Eduardo Martinelli Junior
CONTEXT: Central diabetes insipidus (CDI) is a rare cause of hypernatremia during the neonatal period. The diagnosis is particularly difficult in very low birth weight (VLBW) newborns. CASE REPORT: We report on a preterm newborn who presented CDI soon after birth. On the third day of life, signs of dehydration were present despite normal fluid supply. The diuresis rate was 4.4 ml/kg/h. Although the fluid supply was then increased, the dehydration continued, with hypernatremia, normal glycemia, diuresis of 7...
February 2015: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/25255707/congenital-central-diabetes-insipidus-and-optic-atrophy-in-a-wolfram-newborn-is-there-a-role-for-wfs1-gene-in-neurodevelopment
#18
Stefano Ghirardello, Elisa Dusi, Bianca Castiglione, Monica Fumagalli, Fabio Mosca
BACKGROUND: Wolfram syndrome (WS) is an autosomal recessive neurodegenerative disorder characterized by diabetes mellitus (DM), optic atrophy (OA), central diabetes insipidus (CDI) and deafness (D). The phenotype of the disease has been associated with several mutations in the WFS1 gene, a nuclear gene localized on chromosome 4. Since the discovery of the association between WFS1 gene and Wolfram syndrome, more than 150 mutations have been identified in WS patients. We previously described the first case of perinatal onset of Wolfram syndrome newborn carrying a segmental uniparental heterodysomy affecting the short arm of chromosome 4 responsible for a significant reduction in wolframin expression...
2014: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/25002871/efficacy-of-hydrochlorothiazide-and-low-renal-solute-feed-in-neonatal-central-diabetes-insipidus-with-transition-to-oral-desmopressin-in-early-infancy
#19
Mary B Abraham, Shripada Rao, Glynis Price, Catherine S Choong
BACKGROUND: The treatment of central diabetes insipidus (DI) with desmopressin in the neonatal period is challenging because of the significant risk of hyponatremia with this agent. The fixed anti-diuresis action of desmopressin and the obligate high fluid intake with milk feeds lead to considerable risk of water intoxication and hyponatremia. To reduce this risk, thiazide diuretics, part of the treatment of nephrogenic DI, were used in conjunction with low renal solute feed and were effective in a single case series of neonatal central DI...
2014: International Journal of Pediatric Endocrinology
https://www.readbyqxmd.com/read/24854529/management-of-central-diabetes-insipidus-with-oral-desmopressin-lyophilisate-in-infants
#20
Hüseyin Anıl Korkmaz, Korcan Demir, Fatma Kaya Kılıç, Demet Terek, Sertaç Arslanoğlu, Ceyhun Dizdarer, Behzat Ozkan
AIM: To assess the efficiency of oral desmopressin lyophilisate (ODL) in neonatal central diabetes insipidus (CDI). METHODS: The characteristics of four newborns with CDI treated with ODL were evaluated. RESULTS: Four newborns with polyuria and hypernatremia were included [male, 2 (50%); mean postnatal age, 19±17 days]. At the time of hypernatremia, the mean serum and urine osmolality values were 310±16 and 179±48 mOsm/kg, respectively...
September 2014: Journal of Pediatric Endocrinology & Metabolism: JPEM
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