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https://www.readbyqxmd.com/read/28045339/imaging-biodistribution-and-efficacy-evaluation-of-188-re-human-serum-albumin-microspheres-via-intraarterial-route-in-an-orthotopic-hepatoma-model
#1
Liang-Cheng Chen, Ya-Jen Chang, Su-Jung Chen, Wan-Chi Lee, Chih-Hsien Chang, Te-Wei Lee, Jui-Hung Shien
Purpose Liver cancer is the second most common cause of death worldwide. This study was to investigate the SPECT/CT, ultrasound, biodistribution and therapeutic evaluation of (188)Re-human serum albumin microspheres ((188)Re-HSAM) in the GP7TB orthotopic hepatoma rat model. Materials and methods HSAM was labeled with (188)Re by using home-made kit and microwave system. The (188)Re-HSAM was administered via intraarterial route. The in vivo distribution of (188)Re-HSAM was determined by biodistribution analysis and nanoSPECT/CT system...
January 3, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28041782/intraarterial-therapy-using-micellar-nanoparticles-incorporating-sn-38-in-a-rabbit-liver-tumor-model
#2
Hideyuki Nishiofuku, Toshihiro Tanaka, Yasushi Fukuoka, Takeshi Sato, Tetsuya Masada, Shota Tatsumoto, Masayuki Sho, Ichiro Yamato, Satoshi Yasuda, Shigeru Matsushima, Masato Takano, Chiho Ohbayashi, Kimihiko Kichikawa
PURPOSE: To evaluate the pharmacokinetics of intraarterial (IA) administration of micellar nanoparticles incorporating SN-38 injection compared with intravenous (IV) administration in a rabbit liver tumor model. MATERIALS AND METHODS: In this animal care committee-approved study, 18 rabbits (mean weight, 3.89 kg; range, 3.20-4.70 kg) with VX2 liver tumors were divided into two groups (IA and IV). Micellar nanoparticles incorporating SN-38 (30 mg/kg) were injected through the left hepatic artery in the IA group and the right femoral vein in the IV group...
December 29, 2016: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28017233/bridging-therapy-with-intravenous-recombinant-tissue-plasminogen-activator-improves-functional-outcome-in-patients-with-endovascular-treatment-in-acute-stroke
#3
Ilko L Maier, Daniel Behme, Marlena Schnieder, Ioannis Tsogkas, Katharina Schregel, Alexander Kleinknecht, Katrin Wasser, Mathias Bähr, Michael Knauth, Marios Psychogios, Jan Liman
BACKGROUND: Although endovascular treatment for proximal cerebral vessel occlusion is very effective, it remains controversial if intravenous thrombolysis (IVT) prior to endovascular treatment is superior compared to endovascular treatment alone. In this study we compared functional outcomes and recanalization rates of endovascularly treated stroke patients with and without bridging IVT. METHODS: Patients with acute large artery occlusion within the anterior and posterior cerebral circulation eligible for intraarterial revascularization with and without prior IVT were included in this monocentric, prospective observational study...
January 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27903193/three-dimensional-assessment-of-the-effects-of-high-density-embolization-material-on-the-absorbed-dose-in-the-target-for-gamma-knife-radiosurgery-of-arteriovenous-malformations
#4
Yoichi Watanabe, Divyajot Sandhu, Leighton Warmington, Sean Moen, Ramachandra Tummala
OBJECTIVE Arteriovenous malformation (AVM) is an intracranial vascular disorder. Gamma Knife radiosurgery (GKRS) is used in conjunction with intraarterial embolization to eradicate the nidus of AVMs. Clinical results indicate that patients with prior embolization tend to gain less benefit from GKRS. The authors hypothesized that this was partly caused by dosimetric deficiency. The actual dose delivered to the target may be smaller than the intended dose because of increased photon attenuation by high-density embolic materials...
December 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27886888/imaging-of-oculomotor-third-cranial-nerve-palsy
#5
REVIEW
Michael S Vaphiades, Glenn H Roberson
When evaluating a patient with an oculomotor cranial nerve palsy it may be unclear which neuroimaging modality is optimal; MRI, MR angiography, computed tomography, computed tomography angiography, or intraarterial digital subtraction angiography. We discuss the clinical guidelines in the evaluation of such patients and review neuroimaging techniques, outlining the advantages and disadvantages of each.
February 2017: Neurologic Clinics
https://www.readbyqxmd.com/read/27884686/intraarterial-lidocaine-for-pain-control-in-uterine-artery-embolization-a-prospective-randomized-study
#6
Maxime Noel-Lamy, Kong T Tan, Martin E Simons, Kenneth W Sniderman, Oleg Mironov, Dheeraj K Rajan
PURPOSE: To assess efficacy of two different techniques of lidocaine injection in the uterine arteries to reduce pain following uterine artery embolization (UAE) for leiomyomas. MATERIALS AND METHODS: This prospective randomized single-blinded study was performed with 60 patients enrolled between November 2014 and December 2015 equally randomized to 3 arms. Group A received 10 mL lidocaine 1% (100 mg) mixed with polyvinyl alcohol particles (355-500 μm). Group B received the same dose of lidocaine injected after embolization...
January 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/27875900/effects-of-necrostatin-1-an-inhibitor-of-necroptosis-and-its-inactive-analogue-nec-1i-on-basal-cardiovascular-function
#7
A Szobi, T Rajtik, A Adameova
Inhibition of receptor-interacting serine/threonine-protein kinase 1 (RIP1) by necrostatin-1 (Nec-1) alleviates cardiac injury due to prevention of necroptotic cell death. Its inactive analogue necrostatin-1i (Nec-1i), lacking RIP1 activity, serves as a suitable control. It is unknown if these agents influence the heart function in the absence of damaging stimuli. For this purpose, we measured intraarterial blood pressure (systolic - sBP and diastolic - dBP) and ECG parameters after a bolus administration of Nec-1 and Nec-1i in rats during 30 min...
November 23, 2016: Physiological Research
https://www.readbyqxmd.com/read/27857862/neurosurgery-concepts-key-perspectives-on-intrathecal-fluorescein-for-detecting-intraoperative-cerebrospinal-fluid-leak-during-endoscopic-endonasal-surgery-spinal-intraarterial-chemotherapy-oligoastrocytoma-classification-by-in-situ-molecular-genetics-and-prenatal
#8
https://www.readbyqxmd.com/read/27787452/rhegmatogenous-retinal-detachment-after-intraarterial-chemotherapy-for-retinoblastoma-the-2016-founders-award-lecture
#9
Carol L Shields, Emil A T Say, Maria Pefkianaki, Carl D Regillo, Emi H Caywood, Pascal M Jabbour, Jerry A Shields
PURPOSE: To evaluate rhegmatogenous retinal detachment (RRD) in eyes with retinoblastoma after intraarterial chemotherapy (IAC). DESIGN: Retrospective case series. METHODS: Chart review. MAIN OUTCOME MEASURE: Development of RRD in the IAC era. RESULTS: Of 167 eyes in 157 consecutive patients, mean patient age at diagnosis of retinoblastoma was 19 months. Intraarterial chemotherapy was primary (75/167, 45%) or secondary (92/167, 55%)...
October 26, 2016: Retina
https://www.readbyqxmd.com/read/27767350/transradial-approach-for-hepatic-radioembolization-initial-results-and-technique
#10
Vivian L Bishay, Derek M Biederman, Thomas J Ward, Imramsjah Martijn J van der Bom, Rahul S Patel, Edward Kim, Francis S Nowakowski, Robert A Lookstein, Aaron M Fischman
OBJECTIVE: The transradial approach (TRA) has been shown to reduce the morbidity and mortality associated with arterial coronary interventions. Selective internal radiation therapy (SIRT) performed via the TRA can enhance patient comfort, compared with the traditional transfemoral approach (TFA), by allowing immediate ambulation and precluding potential complications associated with the TFA, such as closure device injury or retroperitoneal hematoma. We report our initial experience with and technique for using the TRA for SIRT...
November 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27757364/microcirculatory-response-in-vivo-on-local-intraarterial-infusion-of-autogenic-adipose-derived-stem-cells-or-stromal-vascular-fraction
#11
Wei Z Wang
: Both adipose-derived stem cells (ASCs) and stromal vascular fraction (SVF) have been demonstrated to have regenerative properties with therapeutic potential for numerous diseases through local or topical applications. However, it is unclear whether ASC or SVF can be delivered systemically through an intra-arterial infusion. The purpose of this study was to examine the microcirculatory response in vivo on local intraarterial infusion of autogenic ASCs or SVF in a vascular pedicle isolated rat cremaster microcirculation model...
September 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27733753/unresectable-liver-metastases-in-colorectal-cancer-review-of-current-strategies
#12
Benjamin Sueur, Olivier Pellerin, Thibault Voron, Anne L Pointet, Julien Taieb, Simon Pernot
The objective of the treatment of colorectal cancer patients with unresectable liver metastases should be clearly defined at the outset. Potentially resectable patients should be distinguished from clearly unresectable patients. In defining resectability, it is important to take into account both anatomic characteristics and patient characteristic (comorbidities, symptoms, age). According to this evaluation, treatment should be tailored to each patient. The most widely accepted standard is doublet cytotoxic regimen plus biotherapy (anti-EGFR or anti-VEGF antibodies according to RAS status, but some patients could benefit from an intensified regimen, as triplet chemotherapy ± bevacizumab, or intraarterial treatments (hepatic arterial infusion, radioembolization or chemoembolization), in order to allow resectability...
December 2016: Minerva Chirurgica
https://www.readbyqxmd.com/read/27664152/endovascular-treatment-of-thrombosis-and-embolism
#13
Ahmet Yigit Goktay, Cagin Senturk
Deep venous thrombosis (DVT) is a common disorder with a significant mortality rate. Successful endovascular treatment of acute DVT is most likely to be achieved in patients with recently formed thrombus, (<10-14 days) with acute iliofemoral DVT. Endovascular treatment options include: Catheter-directed thrombolysis (CDT), pharmacomechanical catheter-directed thrombolysis (PCDT), percutaneous aspiration thrombectomy (PAT), vena cava filter protection, venous balloon dilatation and venous stent implantation...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27641641/renal-cell-carcinoma-metastatic-to-the-liver-early-response-assessment-after-intraarterial-therapy-using-3d-quantitative-tumor-enhancement-analysis
#14
Florian Nima Fleckenstein, Rüdiger Egbert Schernthaner, Rafael Duran, Jae Ho Sohn, Sonia Sahu, Karen Marshall, MingDe Lin, Bernhard Gebauer, Julius Chapiro, Riad Salem, Jean-François Geschwind
PURPOSE: Liver metastases from renal cell carcinoma (RCC) are not uncommon in the course of disease. However, data about tumor response to intraarterial therapy (IAT) are scarce. This study assessed whether changes of enhancing tumor volume using quantitative European Association for the Study of the Liver (qEASL) on magnetic resonance imaging (MRI) and computed tomography (CT) can evaluate tumor response and predict overall survival (OS) early after therapy. METHODS AND MATERIALS: Fourteen patients with liver metastatic RCC treated with IAT (transarterial chemoembolization: n= 9 and yttrium-90: n= 5) were retrospectively included...
October 2016: Translational Oncology
https://www.readbyqxmd.com/read/27603673/passive-entrapment-of-tumor-cells-determines-metastatic-dissemination-to-spinal-bone-and-other-osseous-tissues
#15
Thomas Broggini, Andras Piffko, Christian J Hoffmann, Christoph Harms, Peter Vajkoczy, Marcus Czabanka
During the metastatic process tumor cells circulate in the blood stream and are carried to various organs. In order to spread to different organs tumor cell-endothelial cell interactions are crucial for extravasation mechanisms. It remains unclear if tumor cell dissemination to the spinal bone occurs by passive entrapment of circulating tumor cells or by active cellular mechanisms mediated by cell surface molecules or secreted factors. We investigated the seeding of three different tumor cell lines (melanoma, lung and prostate carcinoma) to the microvasculature of different organs...
2016: PloS One
https://www.readbyqxmd.com/read/27570387/factors-influencing-nonadministration-of-thrombolytic-therapy-in-early-arrival-strokes-in-a-university-hospital-in-hyderabad-india
#16
Lalitha Pidaparthi, Anitha Kotha, Venkat Reddy Aleti, Abhijeet Kumar Kohat, Mridula R Kandadai, Suryaprabha Turaga, Jabeen A Shaik, Suvarna Alladi, Meena A Kanikannan, Borgohain Rupam, Subhash Kaul
BACKGROUND: It is a well-known fact that very few patients of stroke arrive at the hospital within the window period of thrombolysis. Even among those who do, not all receive thrombolytic therapy. OBJECTIVE: The objectives of this study were to determine the proportion of early arrival ischemic strokes (within 6 h of stroke onset) in our hospital and to evaluate the causes of nonadministration of intravenous and/or intraarterial thrombolysis in them. MATERIALS AND METHODS: Data of all early arrival acute stroke patients between January 2010 and January 2015 were included...
July 2016: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/27562620/feasibility-and-midterm-results-of-endovascular-treatment-of-hepatic-artery-occlusion-within-24-hours-after-living-donor-liver-transplantation
#17
In Joon Lee, Seong Hoon Kim, Seung Duk Lee, Jae Hwan Lee, Hyun Beom Kim
PURPOSE: To evaluate the feasibility and midterm results of endovascular treatment of hepatic artery occlusion within 24 hours after living-donor liver transplantation (LDLT). MATERIALS AND METHODS: From January 2012 to June 2014, 189 consecutive patients at a single institution underwent LDLT with right-lobe grafts. Among them, 10 were diagnosed with hepatic artery occlusion within 24 hours after LDLT. All 10 underwent endovascular treatment, including drug-eluting stent placement (n = 2), intraarterial thrombolysis (n = 5), or both (n = 3)...
August 22, 2016: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/27548820/vascular-endothelial-growth-factor-up-regulation-in-human-amniotic-fluid-stem-cell-enhances-nephroprotection-after-ischemia-reperfusion-injury-in-the-rat
#18
Marina Gabriela Monteiro Carvalho Mori da Cunha, Silvia Zia, Diego Vilibaldo Beckmann, Marianne Sylvia Carlon, Fanny Oliveira Arcolino, Maarten Albersen, Ney Luis Pippi, Dominguita Lühers Graça, Conny Gysemans, Peter Carmeliet, Elena Levtchenko, Jan Deprest, Jaan Toelen
OBJECTIVE: To evaluate if the up-regulation of vascular endothelial growth factor strengthens the protective effect of amniotic fluid stem cells in a renal ischemia-reperfusion injury model. DESIGN: Randomized animal study. SETTINGS: University research laboratory. SUBJECTS: A total of 40 males 12-week-old Wistar rats were subjected to ischemia-reperfusion and assigned to four groups: amniotic fluid stem cells, vascular endothelial growth factor-amniotic fluid stem cells in two different doses, and vehicle...
January 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/27508572/-op-8c-07-depletion-of-the-p22phox-gene-reduced-blood-pressure-response-to-glu-injection-into-rvlm-in-shrsp
#19
H Zahid, M Ferdaus, H Ohara, M Isomura, T Nabika
OBJECTIVE: Oxidative stress in the rostral ventrolateral medulla (RVLM), a sympathetic center in brainstem, was implicated in the regulation of sympathetic activity in various hypertensive models including SHRSP. To elucidate pathophysiological roles of oxidative stress in SHRSP, we constructed a new congenic strain (referred to as SP.MES) by introducing a mutated P22phox gene of the Matsumoto Eosinophilic Shinshu (MES) rat into SHRSP. DESIGN AND METHOD: The null mutation of P22phox in the MES rat was introduced in SHRSP by the speed congenial method...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27477992/surgical-treatment-options-for-septic-non-union-of-the-tibia-two-staged-operation-flow-through-anastomosis-of-fvfg-and-continuous-local-intraarterial-infusion-of-heparin
#20
Ryoichi Kawakami, Soichi Ejiri, Michiyuki Hakozaki, Satoshi Hatashita, Nobuyuki Sasaki, Yoshitaka Kobayashi, Yoko Takahashi, Shin-Ichi Konno
BACKGROUND: The treatment of septic non-union of the tibia is a challenging area. The objective of this clinical study was to improve the treatment outcomes in patients with a highly active infection by the three strategies consisting of a two-staged operation, a flow-through technique for vascular anastomosis of a free vascularized fibular graft (FVFG), and continuous local intra-arterial infusion of heparin. PATIENTS & METHOD: Five patients with septic non-union of the tibia who were treated with an FVFG (mean age: 52...
December 16, 2016: Fukushima Journal of Medical Science
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