Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Meichao Dong, Tuo Yin, Dongguo Zhou, Hanyao Zhang, Fan Yang, Shaohua Wang, Chunrui Long, Xiaomeng Fu, Hongming Liu, Lina Guo, Junyan Gao
'Allen Eureka' is a bud variety of Eureka lemon with excellent fruiting traits, but severe winter defoliation affects the following year's yield, and the response mechanism of lemon defoliation is currently unknown. Two lemon cultivars ('Allen Eureka' and 'Yunning No. 1') with different defoliation traits were used as materials to investigate the molecular regulatory mechanisms of different leaf abscission periods in lemons. The petiole abscission zone was collected at three different defoliation stages, namely, the predefoliation stage (k15), the middefoliation stage (k30), and the postdefoliation stage (k45)...
2024: PloS One
#2
JOURNAL ARTICLE
Mirjam Grimm, Lucie Ziegler, Annina Seglias, Maamed Mademilov, Kamila Magdieva, Gulzada Mirzalieva, Aijan Taalaibekova, Simone Suter, Simon R Schneider, Fiona Zoller, Vera Bissig, Lukas Reinhard, Meret Bauer, Julian Müller, Tanja L Ulrich, Arcangelo F Carta, Patrick R Bader, Konstantinos Bitos, Aurelia E Reiser, Benoit Champigneulle, Damira Ashyralieva, Philipp M Scheiwiller, Silvia Ulrich, Talant M Sooronbaev, Michael Furian, Konrad E Bloch
Grimm, Mirjam, Lucie Ziegler, Annina Seglias, Maamed Mademilov, Kamila Magdieva, Gulzada Mirzalieva, Aijan Taalaibekova, Simone Suter, Simon R. Schneider, Fiona Zoller, Vera Bissig, Lukas Reinhard, Meret Bauer, Julian Müller, Tanja L. Ulrich, Arcangelo F. Carta, Patrick R. Bader, Konstantinos Bitos, Aurelia E. Reiser, Benoit Champigneulle, Damira Ashyralieva, Philipp M. Scheiwiller, Silvia Ulrich, Talant M. Sooronbaev, Michael Furian, and Konrad E. Bloch. SARS-CoV-2 Transmission during High-Altitude Field Studies...
April 18, 2024: High Altitude Medicine & Biology
#3
JOURNAL ARTICLE
Lihua Yin, Yifang Hu, Xiaoxia Hu, Xiaolei Huang, Yingyuan Chen, Yisheng Zhang
Gestational diabetes mellitus (GDM) is a frequent complication of pregnancy. The specific mechanisms underlying GDM have not yet been fully elucidated. Contemporary research indicates a potential association between liver enzyme irregularities and an increased risk of metabolic disorders, including diabetes. The alanine aminotransferase (ALT) level is recognized as a sensitive marker of liver injury. An increase in ALT levels is hypothesized to be linked to the pathogenesis of insulin resistance and diabetes...
April 18, 2024: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
#4
JOURNAL ARTICLE
Daniel M Beswick, Christine M Liu, Jonathan B Overdevest, Anna Zemke, Aastha Khatiwada, David A Gudis, Jessa E Miller, Adam Kimple, Jeremy P Tervo, Emily DiMango, Jennifer L Goralski, Claire Keating, Brent Senior, Amanda L Stapleton, Patricia H Eshaghian, Jess C Mace, Karolin Markarian, Jeremiah A Alt, Todd E Bodner, Naweed I Chowdhury, Anne E Getz, Peter H Hwang, Ashoke Khanwalker, Jivianne T Lee, Douglas A Li, Meghan Norris, Jayakar V Nayak, Cameran Owens, Zara M Patel, Katie Poch, Rodney J Schlosser, Kristine A Smith, Timothy L Smith, Zachary M Soler, Jeffrey D Suh, Grant A Turner, Marilene B Wang, Milene T Saavedra, Jennifer L Taylor Cousar
OBJECTIVES: The 22-question SinoNasal Outcome Test (SNOT-22) assesses chronic rhinosinusitis (CRS) severity. We aimed to identify predictors of SNOT-22 score improvement following highly effective modulator therapy (HEMT) initiation and to corroborate the SNOT-22 minimal clinically important difference (MCID) in adults with cystic fibrosis (CF). METHODS: Prospective observational data was pooled from four studies across 10 US centers investigating people with CF (PwCF) and CRS...
April 18, 2024: Laryngoscope
#5
JOURNAL ARTICLE
Özge Özgen-Top, Pınar Aysert-Yıldız, Hasan Selçuk Özger, Özlem Güzel-Tunçcan
OBJECTIVE: Influenza is among the most important respiratory infections affecting all age groups and can lead to hospitalizations. We aimed to determine the frequency of influenza infections among acute admissions with influenza-like illness (ILI) and evaluate the demographic, clinical findings, and outcomes of patients with influenza. METHODS: This prospective, active surveillance study was conducted in a university hospital between 2015 and 2017. Patients hospitalized for at least 24 hours in the selected units with community-acquired ILI were screened according to certain influenza-predicting ICD-10 codes...
December 2023: Infect Dis Clin Microbiol
#6
JOURNAL ARTICLE
Xianhua Li, Wenqing Hao, Sen Lin, Nailong Yang
OBJECTIVE: This study aimed to explore the association between the aspartate aminotransferase to alanine aminotransferase ratio (AST/ALT ratio) and diabetic retinopathy (DR) in patients with type 2 diabetes. METHODS: In this cross-sectional study, clinical data from 3002 patients with type 2 diabetes admitted to the Department of Endocrinology of our hospital between January 1, 2021, and December 1, 2022, were retrospectively collected. Measurements of AST and ALT were conducted and diabetes-related complications were screened...
2024: Frontiers in Endocrinology
#7
JOURNAL ARTICLE
Gülşah Tunçer, Ceyda Geyiktepe-Güçlü, Osman Faruk Bayramlar, Burcu Atasoy-Bozan, Çiğdem Yücel, Serkan Sürme, Betül Çopur, Kadir Görkem Güçlü, Khalis Mustafayev, Türkan İkizceli, Esen Gül Uzuner, Mustafa Yıldırım, Gönül Şengöz, Filiz Pehlivanoglu
OBJECTIVE: This study aimed to determine the predictors for significant hepatic abnormality (SHA), a treatment indication, by assessing demographic, laboratory, and radiological results of chronic hepatitis B (CHB) patients who underwent liver biopsy. MATERIALS AND METHODS: In this retrospective study, individuals with untreated hepatitis B e-antigen (HBeAg)-negative CHB infection were enrolled. Multivariate analysis modeling was conducted with parameters identified as predictors for SHA in univariate analysis...
March 2024: Infect Dis Clin Microbiol
#8
JOURNAL ARTICLE
H Ashktorab, G Oskrochi, S R Challa, L G Chirumamilla, S Saroya, S Dusmatova, N Shayegh, V Nair, K Senthilvelan, D Byer, N Morrison, B Grossi, A Barclay, T Smith, K Watson, M Rashid, R Rashid, M Deverapalli, G Latella, J M Carethers, A Youssef, H Brim
Patients with cancer are known to have a poor prognosis when infected with SARS-CoV-2 infection. We aimed in this study to assess health outcomes in COVID-19 patients with different cancers in comparison to non-cancer COVID-19 patients from different centers in the United States (US). We evaluated medical records of 1,943 COVID-19 Cancer patients from 3 hospitals admitted between December 2019 to October 2021 and compared them with non-cancer COVID-19 patients. Among 1,943 hospitalized COVID-19 patients, 18...
2024: Ann Clin Med Case Rep
#9
JOURNAL ARTICLE
Eman Ebissy, Asmaa Darwish, Amani A Hafez, Ahmed Ateya, Ahmed El-Sayed
BACKGROUND: Mastitis in goats is unquestionably a grave concern, with far-reaching implications for both animal well-being and productivity, while also presenting a potential threat to public health. AIM: The study aimed to compare culture methods and multiplex PCR (m-PCR) in the detection of the most three common mastitis-causing pathogens ( Staphylococcus aureus , Escherichia coli , and Streptococcus spp.) and investigate the gene expression, single nucleotide polymorphisms (SNPs), serum concentrations of immunological and antioxidant indicators linked to mastitis in Shami goats...
January 2024: Open Veterinary Journal
#10
JOURNAL ARTICLE
Mona A Mohammed, Nagat M Amer, Heba M I Abdallah, Mai S Saleh
Improper management of agricultural and industrial cotton wastes causes environmental pollution and worsens the climate change challenge. Green recycling of cotton could contribute to a circular economy. One of the economic values of cotton wastes lies in their bioactive components. Two types of cotton wastes-agricultural and industrial-of the species Gossypium barbadense L. Giza 95 were targeted in the current study, aiming to maximize their medicinal value and investigate the anti-inflammatory, hepatoprotective, and antioxidant activities of their phytochemical extracts...
April 17, 2024: Plant Methods
#11
JOURNAL ARTICLE
Laura Peña-Blanco, Laura Gutiérrez-Soriano, Félix Ramón Montes, Andrea Barragán-Méndez, Susana Beltrán-Villegas, Juan José López-Reyes, Carlos A Villa-Hincapié, Juan Pablo Umaña
BACKGROUND: Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome is a severe adverse drug reaction marked by delayed hypersensitivity reactions causing skin and systemic complications. DRESS diagnosis is challenging due to the variety of clinical presentations and symptom overlap with other conditions. The perioperative period in these patients requires precise pharmacological strategies to prevent complications associated with this syndrome. The treatment of DRESS induced by unfractionated heparin during cardiopulmonary bypass (CPB) surgery presents some challenges that must be considered when selecting an anticoagulant to avoid side effects...
April 17, 2024: Journal of Cardiothoracic Surgery
#12
JOURNAL ARTICLE
Neus Carrilero, Anna García-Altés
BACKGROUND: Since 2008, children in Catalonia (Spain) have suffered a period of great economic deprivation. This situation has generated broad-ranging health inequalities in a variety of diseases. It is not known how these inequalities have changed over time. The aim of the present study is to determine trends in inequalities over this period in ten relevant diseases in children according to sex and age. METHODS: A retrospective cross-sectional population-based study of all children under 15 years old resident in Catalonia during the 2014-2021 period (over 1...
April 17, 2024: International Journal for Equity in Health
#13
JOURNAL ARTICLE
Chaowen Huang, Yu Jiang, Qing Bao, Lu Wang, Lin Tang, Yanjuan Liu, Lei Yang
BACKGROUND: Polygonum multiflorum (PM), a widely used traditional Chinese medicine herb, is divided into two forms, namely raw polygonum multiflorum (RPM) and polygonum multiflorum praeparata (PMP), according to the processing procedure. Emerging data has revealed the differential hepatotoxicity of RPM and PMP, however, its potential mechanism is still unclear. METHODS: In our study, we investigated the differential hepatotoxicity of RPM and PMP exerted in C57BL/6 mice...
April 17, 2024: BMC complementary medicine and therapies
#14
JOURNAL ARTICLE
Jonas Ghouse, Gardar Sveinbjörnsson, Marijana Vujkovic, Anne-Sofie Seidelin, Helene Gellert-Kristensen, Gustav Ahlberg, Vinicius Tragante, Søren A Rand, Joseph Brancale, Silvia Vilarinho, Pia Rengtved Lundegaard, Erik Sørensen, Christian Erikstrup, Mie Topholm Bruun, Bitten Aagaard Jensen, Søren Brunak, Karina Banasik, Henrik Ullum, Niek Verweij, Luca Lotta, Aris Baras, Tooraj Mirshahi, David J Carey, David E Kaplan, Julie Lynch, Timothy Morgan, Tae-Hwi Schwantes-An, Daniel R Dochtermann, Saiju Pyarajan, Philip S Tsao, Triin Laisk, Reedik Mägi, Julia Kozlitina, Anne Tybjærg-Hansen, David Jones, Kirk U Knowlton, Lincoln Nadauld, Egil Ferkingstad, Einar S Björnsson, Magnus O Ulfarsson, Árni Sturluson, Patrick Sulem, Ole B Pedersen, Sisse R Ostrowski, Daniel F Gudbjartsson, Kari Stefansson, Morten Salling Olesen, Kyong-Mi Chang, Hilma Holm, Henning Bundgaard, Stefan Stender
We report a multi-ancestry genome-wide association study on liver cirrhosis and its associated endophenotypes, alanine aminotransferase (ALT) and γ-glutamyl transferase. Using data from 12 cohorts, including 18,265 cases with cirrhosis, 1,782,047 controls, up to 1 million individuals with liver function tests and a validation cohort of 21,689 cases and 617,729 controls, we identify and validate 14 risk associations for cirrhosis. Many variants are located near genes involved in hepatic lipid metabolism...
April 17, 2024: Nature Genetics
#15
JOURNAL ARTICLE
Aryabrata Banerjee, Subhasish Ganguly, Sangita Saha, Pulakendu Bhattacharyya, Satyajit Naskar, Debraj Mukherjee, Shuvadip Ghosh, Prosenjit Maji, Subhranil Saha, Abdur Rahaman Shaikh, Priyanka Ghosh, Chandrima Chatterjee, Munmun Koley, Shyamal Kumar Mukherjee
CONTEXT: Pre-diabetes is a significant public health problem worldwide. India has a very high rate of progression from pre-diabetes to diabetes, 75-78 per thousand persons per year. OBJECTIVE: To study the efficacy of individualized homeopathic medicinal products (HMPs) against placebos in preventing the progression from pre-diabetes to diabetes. DESIGN: Six-month, double-blind, randomized (1:1), two parallel arms, placebo-controlled trial...
April 4, 2024: Explore: the Journal of Science and Healing
#16
JOURNAL ARTICLE
J M Pinazo-Bandera, H Niu, Alvarez-Alvarez, Medina-Caliz, E Del Campo-Herrera, A Ortega-Alonso, M Robles-Díaz, N Hernández, R Paraná, Nunes, M Girala, F Bessone, M I Lucena, R J Andrade, M García Cortés
INTRODUCTION: Data on positive rechallenge in idiosyncratic drug-induced liver injury (DILI) are scarce. We aim to analyse the clinical presentation, outcome and drugs associated with positive rechallenge in two DILI registries. METHODS: Cases from the Spanish and Latin American DILI registries were included. Demographics, clinical characteristics and outcome of cases with positive rechallenge according to CIOMS/RUCAM and current definitions were analysed. RESULTS: Of 1,418 patients with idiosyncratic DILI, 58 cases had positive rechallenge (4...
April 15, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
#17
JOURNAL ARTICLE
Merran Govendir, Larry Vogelnest, Amanda J Shapiro, Caroline Marschner, Benjamin Kimble
The pharmacokinetic profile of paracetamol in koalas is described when administered orally at 15 mg/kg; followed by the same dose, administered every 12 hours (hrs), repeated five times. After the initial oral administration, the median (range) maximal plasma concentration (Cmax), the time Cmax was reached (Tmax) and elimination half-life (t1/2) were 16.93 μg/mL (13.66 to 20.25 μg/mL); 4 hrs (4 to 8 hrs) and 5.54 hrs (4.66 to 7.67 hrs), respectively. When paracetamol was administered orally at 15 mg/mL every 12 hrs, the trough total plasma concentration range remained comparable to the therapeutic range in humans i...
2024: PloS One
#18
JOURNAL ARTICLE
Allison N Devitt, Abigail L Vargas, Wei Zhu, Benjamin James Des Soye, Fatma Ayaloglu Butun, Tyler Alt, Nicholas Kaley, Glaucio M Ferreira, Graham Moran, Neil L Kelleher, Dali Liu, Richard B Silverman
Human ornithine aminotransferase ( h OAT), a pyridoxal 5'-phosphate (PLP)-dependent enzyme, has been shown to play an essential role in the metabolic reprogramming and progression of hepatocellular carcinoma (HCC). HCC accounts for approximately 75% of primary liver cancers and is within the top three causes of cancer death worldwide. As a result of treatment limitations, the overall 5-year survival rate for all patients with HCC is under 20%. The prevalence of HCC necessitates continued development of novel and effective treatment methods...
April 17, 2024: ACS Chemical Biology
#19
JOURNAL ARTICLE
LiLi Gao, YingJie Zhuang, ZhengYi Liu
BACKGROUND: Hepatic fibrosis (HF) is a histopathological change in the process of long-term liver injury caused by cytokine secretion and internal environment disturbance, resulting in excessive liver repair and fiber scar. Nogo-B protein is widely distributed in peripheral tissues and organs and can regulate the migration of endothelial cells by activating TGF-β1 in vascular remodeling after injury. Nogo-B has been shown to promote organ fibrosis. This study was to determine the role of Nogo-B in HF...
April 17, 2024: Tissue Engineering and Regenerative Medicine
#20
JOURNAL ARTICLE
Dominik Szymski, Nike Walter, Josina Straub, Yinan Wu, Oliver Melsheimer, Alexander Grimberg, Volker Alt, Arnd Steinbrueck, Markus Rupp
PURPOSE: Periprosthetic joint infection (PJI) is a major cause of revision surgery after total knee arthroplasty (TKA) and unicondylar knee arthroplasty (UKA). Patient- and hospital-related risk factors need to be assessed to prevent PJI. This study identifies influential factors and differences in infection rates between different implant types. METHODS: Data were obtained from the German Arthroplasty Registry. Septic revisions were calculated using Kaplan-Meier estimates with septic revision surgery as the primary endpoint...
April 17, 2024: Knee Surgery, Sports Traumatology, Arthroscopy
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
