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https://www.readbyqxmd.com/read/29166039/segmental-dynamics-of-polyethylene-alt-propylene-studied-by-nmr-spin-echo-techniques
#1
A Lozovoi, C Mattea, M Hofmann, K Saalwaechter, N Fatkullin, S Stapf
Segmental dynamics of a highly entangled melt of linear polyethylene-alt-propylene with a molecular weight of 200 kDa was studied with a novel proton nuclear magnetic resonance (NMR) approach based upon (1)H → (2)H isotope dilution as applied to a solid-echo build-up function I(SE)(t), which is constructed from the NMR spin echo signals arising from the Hahn echo (HE) and two variations of the solid-echo pulse sequence. The isotope dilution enables the separation of inter- and intramolecular contributions to this function and allows one to extract the segmental mean-squared displacements in the millisecond time range, which is hardly accessible by other experimental methods...
June 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29165163/the-potential-protective-effect-of-commelina-nudiflora-l-against-carbon-tetrachloride-ccl4-induced-hepatotoxicity-in-rats-mediated-by-suppression-of-oxidative-stress-and-inflammation
#2
Muhammad Dawood Shah, Urban J A D'Souza, Mohammad Iqbal
BACKGROUND: This study aims to assess the hepatoprotective potential of Commelina nudiflora against CCl4-induced hepatic injury in rats. METHOD: Antioxidant activities were determined. Phytochemical analysis was performed by gas chromatography mass spectrometry (GCMS). In the in vivo study, Sprague Dawley rats were pretreated with C. nudiflora (150, 300, and 450 mg kg body weight (b.wt.)) once daily for 14 days followed by two doses of CCl4 (1 ml/kg b.wt.). After 2 weeks, the rats were sacrificed and hepatoprotective analysis was performed...
September 11, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29164621/determining-candidate-single-nucleotide-polymorphisms-in-acquired-laryngotracheal-stenosis
#3
Mursalin M Anis, Natalia Krynetskaia, Zhigen Zhao, Evgeny Krynetskiy, Ahmed M S Soliman
OBJECTIVES/HYPOTHESIS: Despite wide adoption of strategies to prevent injury from prolonged intubation and tracheotomy, acquired laryngotracheal stenosis (ALTS) has not disappeared. ALTS' persistence may be due to patient factors that confer unique susceptibility for some. We sought to identify genetic markers in genes associated with wound healing that could be associated with ALTS. STUDY DESIGN: Case-control study. METHODS: One hundred thirty-eight patients were recruited, 53 patients with ALTS and 85 control patients who underwent intubation or tracheotomy without evidence of ALTS...
November 22, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29164048/a-retrospective-mid-and-long-term-follow-up-study-on-the-changes-in-hematologic-parameters-in-the-highly-exposed-residents-of-the-hebei-spirit-oil-spill-in-taean-south-korea
#4
Young-Hyun Choi, Jee-Young Hong, Moo-Sik Lee
Objectives: This study aimed to analyze changes in hematologic parameters in the residents of the areas highly contaminated by the Hebei Spirit Oil Spill in 2007 and those who participated in the clean-up activities. Methods: According to demographic characteristics, health status and behavior, and level of exposure to oil, we compared the hematologic results in 2009 and 2012 among 701 residents. The hematologic parameters were composed of white blood cell (WBC) count, and levels of hemoglobin, hematocrit (Hct), aspartate aminotransferase (AST), alanine aminotransferase (ALT), glucose, glycosylated hemoglobin (HbA1c), blood urea nitrogen (BUN), creatinine (Cr), total cholesterol (T-chol), high-density lipoprotein (HDL), and triglyceride (TG)...
October 2017: Osong Public Health and Research Perspectives
https://www.readbyqxmd.com/read/29163407/a-therapeutic-antiviral-antibody-inhibits-the-anterograde-directed-neuron-to-cell-spread-of-herpes-simplex-virus-and-protects-against-ocular-disease
#5
Dirk Bauer, Mira Alt, Miriam Dirks, Anna Buch, Christiane S Heilingloh, Ulf Dittmer, Bernd Giebel, André Görgens, Vivien Palapys, Maren Kasper, Anna M Eis-Hübinger, Beate Sodeik, Arnd Heiligenhaus, Michael Roggendorf, Adalbert Krawczyk
Herpes simplex virus (HSV) is a leading cause of blindness and viral encephalitis in the developed world. Upon reactivation from sensory neurons, HSV returns via axonal transport to peripheral tissues where it causes, e.g., severe, potentially blinding ocular diseases. In the present study we investigated whether the HSV-1/2 glycoprotein B-specific antibody mAb 2c or its humanized counterpart mAb hu2c can protect from ocular disease in a mouse model of HSV-1-induced acute retinal necrosis (ARN). In this model the viral spread from the initially infected to the contralateral eye resembles the routes taken in humans upon HSV reactivation...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29163393/the-5bsl3-2-functional-rna-domain-connects-distant-regions-in-the-hepatitis-c-virus-genome
#6
REVIEW
Cristina Romero-López, Alfredo Berzal-Herranz
Viral genomes are complexly folded entities that carry all the information required for the infective cycle. The nucleotide sequence of the RNA virus genome encodes proteins and functional information contained in discrete, highly conserved structural units. These so-called functional RNA domains play essential roles in the progression of infection, which requires their preservation from one generation to the next. Numerous functional RNA domains exist in the genome of the hepatitis C virus (HCV). Among them, the 5BSL3...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29163173/investigation-of-liver-injury-of-polygonum-multiflorum-thunb-in-rats-by-metabolomics-and-traditional-approaches
#7
Yun-Xia Li, Xiao-Hong Gong, Mei-Chen Liu, Cheng Peng, Peng Li, Yi-Tao Wang
Liver injury induced by Polygonum multiflorum Thunb. (PM) have been reported since 2006, which aroused widespread concern. However, the toxicity mechanism of PM liver injury remained unclear. In this study, the mechanism of liver injury induced by different doses of PM after long-term administration was investigated in rats by metabolomics and traditional approaches. Rats were randomly divided into control group and PM groups. PM groups were oral administered PM of low (10 g/kg), medium (20 g/kg), high (40 g/kg) dose, while control group was administered distilled water...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29162770/correlation-of-the-blood-test-results-obtained-between-assays-using-microliter-scale-fingertip-blood-samples-collected-with-a-novel-blood-collection-device-and-conventional-venous-blood-assays-a-secondary-publication-in-english
#8
Hajime Iwasawa, Tomoaki Nishimura, Shota Nemoto, Naoki Aikawa, Kiyoaki Watanabe
In this study, we investigated the correlations between biochemical and hematological test results obtained using microliter-scale fingertip blood samples collected with a newly developed blood collection device and those obtained using conventional venous blood. Eighty volunteer subjects were enrolled in this study. Blood samples were drawn from the fingertip of the ring finger by a single puncture, and 60-µL samples were promptly and accurately aspirated into a blood collection chip. Then the chip was tightly sealed in a chip container and was shaken to mix the contents without dispersion...
November 21, 2017: Keio Journal of Medicine
https://www.readbyqxmd.com/read/29162143/prevalence-and-risk-of-hepatitis-e-virus-infection-in-the-hiv-population-of-nepal
#9
Ananta Shrestha, Anurag Adhikari, Manjula Bhattarai, Ramanuj Rauniyar, Jose D Debes, André Boonstra, Thupten K Lama, Mamun Al Mahtab, Amna Subhan Butt, Sheikh Mohammad Fazle Akbar, Nirmal Aryal, Sapana Karn, Krishna Das Manandhar, Birendra Prasad Gupta
BACKGROUND: Infection with the hepatitis E virus (HEV) can cause acute hepatitis in endemic areas in immune-competent hosts, as well as chronic infection in immune-compromised subjects in non-endemic areas. Most studies assessing HEV infection in HIV-infected populations have been performed in developed countries that are usually affected by HEV genotype 3. The objective of this study is to measure the prevalence and risk of acquiring HEV among HIV-infected individuals in Nepal. METHODS: We prospectively evaluated 459 Human Immunodeficiency Virus (HIV)-positive individuals from Nepal, an endemic country for HEV, for seroprevalence of HEV and assessed risk factors associated with HEV infection...
November 21, 2017: Virology Journal
https://www.readbyqxmd.com/read/29161233/swimming-but-not-vitamin-e-ameliorates-prothrombotic-state-and-hypofibrinolysis-in-a-rat-model-of-nonalcoholic-fatty-liver-disease
#10
Hussein F Sakr, Amr M Abbas, Mohamed A Haidara
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is associated with a systemic procoagulant hypofibrinolysis state that is considered as a risk factor for microangiopathy and peripheral vascular diseases. Swimming exercise ameliorates the metabolic dysfunction in type 2 diabetes. Vitamin E is a natural antioxidant that reduces the risk of endothelial dysfunction in metabolic syndrome. The aim of the present study is to investigate the effect of combined swimming exercise with vitamin E on coagulation as well as blood fibrinolysis markers in rats with NAFLD...
November 21, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29161114/suicide-and-high-altitude-an-integrative-review
#11
Elaine Reno, Talia L Brown, Marian E Betz, Michael H Allen, Lilian Hoffecker, Jeremy Reitinger, Robert Roach, Benjamin Honigman
Reno, Elaine, Talia L. Brown, Marian E. Betz, Michael H. Allen, Lilian Hoffecker, Jeremy Reitinger, Robert Roach, and Benjamin Honigman. Suicide and high altitude: an integrative review. High Alt Med Biol 00:000-000, 2017. INTRODUCTION: Suicide rates are greater at high altitudes, and multiple mechanisms have been suggested for this relationship, including hypoxia, differences in population density, characteristics of suicide victims, and firearms ownership and access. To better understand these potential mechanisms, studies evaluating the associations between high altitude and suicide were examined...
November 21, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29161094/the-effect-of-resistance-training-in-a-hypoxic-chamber-on-physical-performance-in-elite-rugby-athletes
#12
Brad Mayo, Cory Miles, Stacy Sims, Matthew Driller
Mayo, Brad, Cory Miles, Stacy Sims, and Matthew Driller. The effect of resistance training in a hypoxic chamber on physical performance in elite rugby athletes. High Alt Med Biol 00:000-000, 2017.-Limited research suggests that muscle adaptations may be enhanced through resistance training in a hypoxic environment. Seventeen professional rugby union athletes (age [mean ± SD], 24 ± 3 years; body mass, 98.7 ± 12.8 kg; and height, 188.9 ± 7.9 cm), performed 12 resistance training sessions over a 3-week period...
November 21, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29160686/human-hair-keratin-for-biocompatible-flexible-and-transient-electronic-devices
#13
Jieun Ko, Luong Thi Hieun Nguyen, Abhijith Surendran, Bee Yi Tan, Kee Woei Ng, Wei Lin Leong
Biomaterials have been attracting attention as a useful building block for biocompatible and bioresorbable electronics due to its non-toxic property and solution processabillity. In this work, we report the integration of biocompatible keratin from human hair as dielectric layer for organic thin-film transistors (TFTs), with high performance, flexibility and transient property. The keratin dielectric layer exhibited a high capacitance value above 1.27 μF/cm2 at 20 Hz due to the formation of electrical double layer...
November 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29160303/the-pnpla3-i148m-variant-is-associated-with-transaminase-elevations-in-type-2-diabetes-patients-treated-with-basal-insulin-peglispro
#14
S Pillai, S Duvvuru, P Bhatnagar, W Foster, M Farmen, S Shankar, C Harris, E Bastyr, B Hoogwerf, A Haupt
Basal insulin peglispro (BIL) is a novel insulin with hepato-preferential action. In phase 3 trials, BIL showed significantly improved glycemic control but higher levels of transaminases (alanine aminotransferase (ALT) and aspartate aminotransferase (AST)), triglycerides (TGs) and liver fat content (LFC) compared with insulin glargine (GL). As variants in PNPLA3 (I148M) and TM6SF2 (E167K) are associated with nonalcoholic fatty liver disease, we assessed these variants in type 2 diabetes (T2D) patients randomized to receive BIL (n=1822) or GL (n=1270) in three phase 3 trials...
November 21, 2017: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/29159663/infrapatellar-vs-suprapatellar-approach-to-obtain-an-optimal-insertion-angle-for-intramedullary-nailing-of-tibial-fractures
#15
Joerg Franke, Annika Homeier, Lars Metz, Thilo Wedel, Volker Alt, Sven Spät, Bernd Hohendorff, Reinhard Schnettler
BACKGROUND: During intramedullary nailing of tibial fractures, the insertion angle of the nail is of great importance. When the nail impacts the posterior cortex due to a large insertion angle with a dorsal target course, higher insertion forces are needed, and the danger of iatrogenic fractures increases. Accordingly, the insertion direction should be as parallel as possible to the longitudinal axis of the tibia. We aimed to confirm the hypothesis that intramedullary nailing of tibial fractures can be performed with smaller insertion angles via a suprapatellar approach rather than infrapatellar approach...
November 20, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29159591/evaluation-of-the-associations-between-endothelial-dysfunction-inflammation-and-coagulation-in-crimean-congo-hemorrhagic-fever-patients
#16
Halef Okan Doğan, Seyit Ali Büyüktuna, Sercan Kapancik, Sevtap Bakir
Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne zoonotic viral disease. The aim of this study was to evaluate the association between inflammation, coagulation and endothelial dysfunction in CCHF. The study population consisted of 40 patients and 50 healthy controls. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), endocan, high sensitive C-reactive protein (hsCRP), international normalized ratio (INR), prothrombin time (PT), activated partial thromboplastin time (aPTT) and platelets values were determined in blood samples...
November 20, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29159070/primary-cytomegalovirus-infection-in-immunocompetent-adults-in-the-united-states-a-case-series
#17
Nathanial Nolan, Umme-Aiman Halai, Hariharan Regunath, LPatrick Smith, Christian Rojas-Moreno, William Salzer
Primary Cytomegalovirus (CMV) infection is often not suspected as a cause of fever of unknown origin (FUO) in immune-competent adults. We present a case-series of symptomatic primary CMV infection in immunocompetent adults presenting as fever of unknown origin (FUO). All patients with CMV serology tested between November 2008 and June 2016 underwent chart review. Cases were defined as those between 18 and 65 years of age with documented fever and elevated serum anti-CMV IgM. Exclusion criteria were organ specific CMV disease, positive serum anti-EBV IgM, or presence of any immunocompromising condition...
2017: IDCases
https://www.readbyqxmd.com/read/29158809/alkaline-phosphatase-to-albumin-ratio-as-a-prognostic-indicator-in-pancreatic-ductal-adenocarcinoma-after-curative-resection
#18
Ning Pu, Shanshan Gao, Yadong Xu, Guochao Zhao, Yang Lv, Abulimiti Nuerxiati, Jian-Ang Li, Dansong Wang, Xuefeng Xu, Tiantao Kuang, Xiaolin Wang, Wenhui Lou, Lingxiao Liu, Wenchuan Wu
Background: The prognosis of pancreatic ductal adenocarcinoma (PDAC) remains poor and the models for survival prediction in PDAC patients after curative resection are still limited. Preoperative alkaline phosphatase-to-albumin ratio (APAR), an original inflammation-based score, has been established to analyze the prognostic significance in PDAC. Therefore, in this study, we aim to formulate a valuable prognostic nomogram for PDAC following curative resection. Methods: A total of 354 patients with PDAC undergoing curative resection were retrospectively enrolled in this study...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29158666/tenofovir-alafenamide-in-the-treatment-of-chronic-hepatitis-b-design-development-and-place-in-therapy
#19
REVIEW
Eiichi Ogawa, Norihiro Furusyo, Mindie H Nguyen
Tenofovir alafenamide (TAF), a novel prodrug of tenofovir (TFV), has been approved for the treatment of chronic hepatitis B virus (HBV) infection. TAF has been shown to be a potent inhibitor of HBV replication at a low dose, with high intracellular concentration and more than 90% lower systemic TFV concentration than tenofovir disoproxil fumarate (TDF). In two randomized, double-blind, multinational, Phase 3, non-inferiority trials for hepatitis B e antigen (HBeAg)-positive and -negative patients (primary analysis: 48 weeks), TAF 25 mg orally once-daily was not inferior to TDF 300 mg in achieving an HBV DNA level <29 IU/mL at week 48...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29158395/histone-methyltransferase-mmset-promotes-aid-mediated-dna-breaks-at-the-donor-switch-region-during-class-switch-recombination
#20
Hai Vu Nguyen, Junchao Dong, Rohit A Panchakshari, Vipul Kumar, Frederick W Alt, Jean-Christophe Bories
In B cells, Ig class switch recombination (CSR) is initiated by activation-induced cytidine deaminase (AID), the activity of which leads to DNA double-strand breaks (DSBs) within IgH switch (S) regions. Preferential targeting of AID-mediated DSBs to S sequences is critical for allowing diversification of antibody functions, while minimizing potential off-target oncogenic events. Here, we used gene targeted inactivation of histone methyltransferase (HMT) multiple myeloma SET domain (MMSET) in mouse B cells and the CH12F3 cell line to explore its role in CSR...
November 20, 2017: Proceedings of the National Academy of Sciences of the United States of America
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