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https://www.readbyqxmd.com/read/28376622/mechanical-loading-influences-the-viscoelastic-performance-of-the-resin-carious-dentin-complex
#1
Manuel Toledano, Raquel Osorio, Modesto T López-López, Fátima S Aguilera, Franklin García-Godoy, Manuel Toledano-Osorio, Estrella Osorio
The aim of this study was to evaluate the changes in the mechanical behavior and bonding capability of Zn-doped resin-infiltrated caries-affected dentin interfaces. Dentin surfaces were treated with 37% phosphoric acid (PA) followed by application of a dentin adhesive, single bond (SB) (PA+SB) or by 0.5 M ethylenediaminetetraacetic acid (EDTA) followed by SB (EDTA+SB). ZnO microparticles of 10 wt. % or 2 wt. % ZnCl2 was added into SB, resulting in the following groups: PA+SB, PA+SB-ZnO, PA+SB-ZnCl2, EDTA+SB, EDTA+SB-ZnO, EDTA+SB-ZnCl2...
April 4, 2017: Biointerphases
https://www.readbyqxmd.com/read/28363171/severe-soft-tissue-injuries-of-the-upper-extremity-in-motor-vehicle-crashes-involving-partial-ejection-the-protective-role-of-side-curtain-airbags
#2
Robert Kaufman, Laura Fraade-Blanar, Angelo Lipira, Jeffrey Friedrich, Eileen Bulger
INTRODUCTION: Partial ejection (PE) of the upper extremity (UE) can occur in a motor vehicle crash (MVC) resulting in complex and severe soft tissue injuries (SSTI). This study evaluated the relationship between partial ejection and UE injuries, notably SSTIs, in MVCs focusing on crash types and characteristics, and further examined the role of side curtain airbags (SCABs) in the prevention of partial ejection and reducing SSTI of the UE. METHODS: Weighted data was analyzed from the National Automotive Sampling System Crashworthiness Data System (NASS-CDS) from 1993 to 2012...
March 28, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28357395/new-insights-into-the-function-of-a-versatile-class-of-membrane-molecular-motors-from-studies-of-myxococcus-xanthus-surface-gliding-motility
#3
COMMENT
Tâm Mignot, Marcelo Nöllmann
Cell motility is a central function of living cells, as it empowers colonization of new environmental niches, cooperation, and development of multicellular organisms. This process is achieved by complex yet precise energy-consuming machineries in both eukaryotes and bacteria. Bacteria move on surfaces using extracellular appendages such as flagella and pili but also by a less-understood process called gliding motility. During this process, rod-shaped bacteria move smoothly along their long axis without any visible morphological changes besides occasional bending...
March 2, 2017: Microbial Cell
https://www.readbyqxmd.com/read/28346344/increased-force-variability-is-associated-with-altered-modulation-of-the-motorneuron-pool-activity-in-autism-spectrum-disorder-asd
#4
Zheng Wang, Minhyuk Kwon, Suman Mohanty, Lauren M Schmitt, Stormi P White, Evangelos A Christou, Matthew W Mosconi
Force control deficits have been repeatedly documented in autism spectrum disorder (ASD). They are associated with worse social and daily living skill impairments in patients suggesting that developing a more mechanistic understanding of the central and peripheral processes that cause them may help guide the development of treatments that improve multiple outcomes in ASD. The neuromuscular mechanisms underlying force control deficits are not yet understood. Seventeen individuals with ASD and 14 matched healthy controls completed an isometric index finger abduction test at 60% of their maximum voluntary contraction (MVC) during recording of the first dorsal interosseous (FDI) muscle to determine the neuromuscular processes associated with sustained force variability...
March 25, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28281638/mir-34a-5p-promotes-multi-chemoresistance-of-osteosarcoma-through-down-regulation-of-the-dll1-gene
#5
Youguang Pu, Fangfang Zhao, Haiyan Wang, Shanbao Cai
MiR-34a-5p has been implicated in the tumorigenesis and progression of several types of cancer. However, the role of miR-34a-5p in osteosarcoma (OS) remains largely unknown. This study was performed in two multi-chemosensitive (G-292 and MG63.2) and two resistant (SJSA-1 and MNNG/HOS) OS cell lines. MiR-34a-5p promotes OS multi-chemoresistance via its repression of the Delta-like ligand 1 (DLL1) gene, the ligand of the Notch pathway, and thus negatively correlates with OS chemoresistance. The siRNA-mediated repression of the DLL1 gene suppressed cell apoptosis and de-sensitized G-292 and MG63...
March 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28269553/decoding-force-from-deep-brain-electrodes-in-parkinsonian-patients
#6
Syed A Shah, Huiling Tan, Peter Brown
Limitations of many Brain Machine Interface (BMI) systems using invasive electrodes include reliance on single neurons and decoding limited to kinematics only. This study investigates whether force-related information is present in the local field potential (LFP) recorded with deep brain electrodes using data from 14 patients with Parkinson's disease. A classifier based on logistic regression (LR) is developed to classify various force stages, using 10-fold cross validation. Least Absolute and Shrinkage Operator (Lasso) is then employed in order to identify the features with the most predictivity...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28254785/notch-jagged-complex-structure-implicates-a-catch-bond-in-tuning-ligand-sensitivity
#7
Vincent C Luca, Byoung Choul Kim, Chenghao Ge, Shinako Kakuda, Di Wu, Mehdi Roein-Peikar, Robert S Haltiwanger, Cheng Zhu, Taekjip Ha, K Christopher Garcia
Notch receptor activation initiates cell fate decisions and is distinctive in its reliance on mechanical force and protein glycosylation. The 2.5-angstrom-resolution crystal structure of the extracellular interacting region of Notch1 complexed with an engineered, high-affinity variant of Jagged1 (Jag1) reveals a binding interface that extends ~120 angstroms along five consecutive domains of each protein. O-Linked fucose modifications on Notch1 epidermal growth factor-like (EGF) domains 8 and 12 engage the EGF3 and C2 domains of Jag1, respectively, and different Notch1 domains are favored in binding to Jag1 than those that bind to the Delta-like 4 ligand...
March 24, 2017: Science
https://www.readbyqxmd.com/read/28237933/three-dimensional-skin-deformation-as-force-substitution-wearable-device-design-and-performance-during-haptic-exploration-of-virtual-environments
#8
Samuel B Schorr, Allison Okamura
Virtual reality systems would benefit from a compelling force sensory substitute when workspace or stability limitations prevent the use of kinesthetic force feedback systems. We present a wearable fingertip haptic device with the ability to make and break contact in addition to rendering both shear and normal skin deformation to the fingerpad. A delta mechanism with novel bias spring and tether actuator relocation method enables the use of high-end motors and encoders, allowing precise device control: 10 Hz bandwidth and 0...
February 22, 2017: IEEE Transactions on Haptics
https://www.readbyqxmd.com/read/28173613/illumina-sequencing-based-analysis-of-sediment-bacteria-community-in-different-trophic-status-freshwater-lakes
#9
Yu Wan, Xiaohong Ruan, Yaping Zhang, Rongfu Li
Sediment bacterial community is the main driving force for nutrient cycling and energy transfer in aquatic ecosystem. A thorough understanding of the community's spatiotemporal variation is critical for us to understand the mechanisms of cycling and transfer. Here, we investigated the sediment bacterial community structures and their relations with environmental factors, using Lake Taihu as a model system to explore the dependence of biodiversity upon trophic level and seasonality. To combat the limitations of conventional techniques, we employed Illumina MiSeq Sequencing and LeFSe cladogram to obtain a more comprehensive view of the bacterial taxonomy and their variations of spatiotemporal distribution...
February 7, 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/28149554/body-mass-index-percent-forced-vital-capacity-respiratory-hospitalization-new-staging-for-idiopathic-pulmonary-fibrosis-patients
#10
Tomoo Kishaba, Hiroaki Nagano, Yuichiro Nei, Shin Yamashiro
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is relentless progressive interstitial lung disease. Evaluating predictor of mortality for IPF patients is crucial. The aim of this study was to evaluate the serial trend of important indicators of prognosis and create a useful staging method for IPF patients. METHODS: We retrospectively searched medical records, pulmonary function tests (PFTs), and chest high resolution computed tomography (HRCT) scans from January 1, 2008 through June 30, 2015 at our hospital...
December 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28116682/deltas-freshwater-discharge-and-waves-along-the-young-sound-ne-greenland
#11
Aart Kroon, Jakob Abermann, Mette Bendixen, Magnus Lund, Charlotte Sigsgaard, Kirstine Skov, Birger Ulf Hansen
A wide range of delta morphologies occurs along the fringes of the Young Sound in Northeast Greenland due to spatial heterogeneity of delta regimes. In general, the delta regime is related to catchment and basin characteristics (geology, topography, drainage pattern, sediment availability, and bathymetry), fluvial discharges and associated sediment load, and processes by waves and currents. Main factors steering the Arctic fluvial discharges into the Young Sound are the snow and ice melt and precipitation in the catchment, and extreme events like glacier lake outburst floods (GLOFs)...
February 2017: Ambio
https://www.readbyqxmd.com/read/28062612/cardiac-troponin-assays-guide-to-understanding-analytical-characteristics-and-their-impact-on-clinical-care
#12
REVIEW
Fred S Apple, Yader Sandoval, Allan S Jaffe, Jordi Ordonez-Llanos
BACKGROUND: Cardiac troponin I (cTnI) and cardiac troponin T (cTnT) determinations are fixtures in clinical practice and research. Cardiac troponin testing has been the standard of practice for the diagnosis of acute myocardial infarction (AMI), early rule-out, risk stratification, and outcomes assessment in patients presenting with acute coronary syndrome (ACS) and non-ACS myocardial injury. We recognize from reading the literature over the past several years how poorly understood the analytical characteristics are for cTnI and cTnT assays by laboratorians, clinicians, and scientists who use these assays...
January 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28040609/in-situ-observation-of-lubricant-film-formation-in-thr-considering-real-conformity-the-effect-of-diameter-clearance-and-material
#13
D Nečas, M Vrbka, F Urban, J Gallo, I Křupka, M Hartl
The aim of the present study is to provide an analysis of protein film formation in hip joint replacements considering real conformity based on in situ observation of the contact zone. The main attention is focused on the effect of implant nominal diameter, diametric clearance and material. For this purpose, a pendulum hip joint simulator equipped with electromagnetic motors enabling to apply continuous swinging flexion-extension motion was employed. The experimental configuration consists of femoral component (CoCrMo, BIOLOX®forte, BIOLOX®delta) and acetabular cup from optical glass fabricated according to the dimensions of real cups...
December 23, 2016: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28005993/decreased-peak-expiratory-flow-associated-with-muscle-fiber-type-switching-in-spinal-and-bulbar-muscular-atrophy
#14
Shinichiro Yamada, Atsushi Hashizume, Yasuhiro Hijikata, Tomonori Inagaki, Keisuke Suzuki, Naohide Kondo, Kaori Kawai, Seiya Noda, Hirotaka Nakanishi, Haruhiko Banno, Akihiro Hirakawa, Haruki Koike, Katherine Halievski, Cynthia L Jordan, Masahisa Katsuno, Gen Sobue
The aim of this study was to characterize the respiratory function profile of subjects with spinal and bulbar muscular atrophy (SBMA), and to explore the underlying pathological mechanism by comparing the clinical and biochemical indices of this disease with those of amyotrophic lateral sclerosis (ALS). We enrolled male subjects with SBMA (n = 40) and ALS (n = 25) along with 15 healthy control subjects, and assessed their respiratory function, motor function, and muscle strength. Predicted values of peak expiratory flow (%PEF) and forced vital capacity were decreased in subjects with SBMA compared with controls...
2016: PloS One
https://www.readbyqxmd.com/read/27916688/effects-of-repeated-treatment-with-a-delta-opioid-receptor-agonist-knt-127-on-hyperemotionality-in-olfactory-bulbectomized-rats
#15
Leo Gotoh, Akiyoshi Saitoh, Misa Yamada, Hideaki Fujii, Hiroshi Nagase, Mitsuhiko Yamada
We previously demonstrated that a single treatment of a non-peptidic delta opioid receptor agonist, KNT-127, has an antidepressant-like effect in rodents in the forced swim test. Here we evaluated the effect of repeated administration of the potential antidepressant KNT-127 in an olfactory-bulbectomized (OBX) rat model. Male Wistar rats (8-12 weeks old) underwent olfactory bulbectomy. From 14days after surgery each was weighed and administered either KNT-127 (3mgkg(-1)/day), the selective serotonin reuptake inhibitor (SSRI) fluoxetine (10mgkg(-1)/day), or vehicle, daily for 14 days...
April 14, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/27915392/sediment-suspension-and-the-dynamic-mechanism-during-storms-in-the-yellow-river-delta
#16
Shuhua Bian, Zjian Hu, Jianqiang Liu, Zichen Zhu
The suspension and hydrodynamic characteristics of the Yellow River Delta during storms were analyzed based on suspended samples obtained using automatic samplers during a storm event in the Yellow River Delta. Synchronous data for winds, waves, and tides were also collected from a nearby station. The results show that under wind speeds of 5-15 m/s and wave heights of 50-150 cm, the suspended content reached 5.7-49.6 kg/m(3), which is 10-100 times higher than that under normal weather conditions. The medium diameter of suspended particles was 1...
December 2016: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/27807273/a-new-mechanism-for-spatial-pattern-formation-via-lateral-and-protrusion-mediated-lateral-signalling
#17
Zena Hadjivasiliou, Ginger L Hunter, Buzz Baum
Tissue organization and patterning are critical during development when genetically identical cells take on different fates. Lateral signalling plays an important role in this process by helping to generate self-organized spatial patterns in an otherwise uniform collection of cells. Recent data suggest that lateral signalling can be mediated both by junctional contacts between neighbouring cells and via cellular protrusions that allow non-neighbouring cells to interact with one another at a distance. However, it remains unclear precisely how signalling mediated by these distinct types of cell-cell contact can physically contribute to the generation of complex patterns without the assistance of diffusible morphogens or pre-patterns...
November 2016: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/27734456/-opioidergic-postconditioning-of-heart-muscle-during-ischemia-reperfusion-injury
#18
Marcin Kunecki, Wojciech Płazak, Tomasz Roleder, Jolanta Biernat, Tomasz Oleksy, Piotr Podolec, Krzysztof Stanisław Gołba
BACKGROUND: Ischemic preconditioning (IPC) and postconditioning (POC) are the novel strategies of attaining cardioprotection against ischemia/reperfusion (I/R) injury. Previous studies suggested the role of opioid pathway, however the class of opioid receptors responsible for this effect in humans remains unknown. The aim of the study was to assess the influence of opioids on simulated I/R injury outcomes in the human myocardium. METHODS: Trabeculae of the human right atrium were electrically driven in organ bath and subjected to simulated I/R injury...
October 13, 2016: Cardiology Journal
https://www.readbyqxmd.com/read/27709074/correlation-of-delta-high-resolution-computed-tomography-hrct-score-with-delta-clinical-variables-in-early-systemic-sclerosis-ssc-patients
#19
Suparaporn Wangkaew, Juntima Euathrongchit, Pittaporn Wattanawittawas, Nuntana Kasitanon
BACKGROUND: The correlation of changes (delta: Δ) of high-resolution computed tomography (HRCT) score with the Δ of other clinical variables has not been well studied. The purpose of this study was to determine the correlation of Δ HRCT score with Δ percent predicted forced vital capacity (%pFVC), Δ modified Rodnan Skin Score (mRSS), Δ erythrocyte sedimentation rate (ESR), and Δ percent of oxygen saturation at room air (%SpO2) in patients with early systemic sclerosis (SSc). METHODS: We used an inception cohort of early-SSc patients seen at the Rheumatology Clinic, Chiang Mai University, Thailand, between January 2010 and June 2014...
August 2016: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/27684742/production-of-materials-with-spatially-controlled-cross-link-density-via-vat-photopolymerization
#20
Gregory I Peterson, Johanna J Schwartz, Di Zhang, Benjamin M Weiss, Mark A Ganter, Duane W Storti, Andrew J Boydston
We describe an efficient method to produce objects comprising spatially controlled and graded cross-link densities using vat photopolymerization additive manufacturing (AM). Using a commercially available diacrylate-based photoresin, 3D printer, and digital light processing (DLP) projector, we projected grayscale images to print objects in which the varied light intensity was correlated to controlled cross-link densities and associated mechanical properties. Cylinder and bar test specimens were used to establish correlations between light intensities used for printing and cross-link density in the resulting specimens...
October 11, 2016: ACS Applied Materials & Interfaces
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