Delta force

The severe acute respiratory syndrome coronavirus 2 pandemic is characterized by the emergence of novel variants of concern (VOCs) that replace ancestral strains. Here, we dissect the complex selective pressures by evaluating variant fitness and adaptation in human respiratory tissues. We evaluate viral properties and host responses to reconstruct forces behind D614G through Omicron (BA.1) emergence. We observe differential replication in airway epithelia, differences in cellular tropism, and virus-induced cytotoxicity...

Our extensive field studies demonstrate that saline groundwater inland and freshened groundwater offshore coexist in the same aquifer system in the Pearl River delta and its adjacent shelf. This counterintuitive phenomenon challenges the commonly held assumption that onshore groundwater is typically fresh, while offshore groundwater is saline. To address this knowledge gap, we conduct a series of sophisticated paleo-hydrogeological models to explore the formation mechanism and evolution process of the groundwater system in the inland-shelf systems...

PURPOSE: Metabolic syndrome (MetS) is a common disorder associated with disturbed neurotransmitter homeostasis. Memantine, an N-methyl-d-aspartate receptor (NMDAR) antagonist, was first used in Alzheimer's disease. Allopregnanolone (Allo), a potent positive allosteric modulator of the Gamma-Amino-Butyric Acid (GABA)-A receptors, decreases in neurodegenerative diseases. The study investigated the impact of Memantine versus Allo administration on the animal model of MetS to clarify whether the mechanism of abnormalities is related more to excitatory or inhibitory neurotransmitter dysfunction...

The coarse-grained (CG) model serves as a powerful tool for the simulation of polymer systems; its reliability depends on the accurate representation of both structural and dynamical properties. However, strong correlations between structural and dynamical properties on different scales and also a strong memory effect, enforced by chain connectivity between monomers in polymer systems, render developing a chemically specific systematic CG model a formidable task. In this study, we report a systematic CG approach that combines the iterative Boltzmann inversion (IBI) method and the generalized Langevin equation (GLE) dynamics...

BACKGROUND: The Braden scale, one of the most widely used risk assessment tools is often criticized when used in the Intensive Care Unit. Most patients in the Intensive Care Unit are at risk of pressure ulcer development meaning that the Braden score will usually indicate high risk for these patients. This study set out to determine the correlation between Sub-Epidermal Moisture measurements and Braden scores among Intensive Care Unit patients. METHODS: This study employed an observational research design...

Understanding how environmental factors affect species distribution is crucial for the conservation and management of marine organisms, especially in the face of global changes. Whiting (Merlangius merlangus) is a demersal cold-temperate fish, considered a 'relict species' in the Adriatic Sea. Despite its significance to commercial fisheries in the region, the specific drivers behind its spatial and temporal patterns have not been thoroughly examined. Here, we fitted a set of Generalized Linear Mixed Effects Models to data collected in the Northern and Central Adriatic from 1999 to 2019 during the Mediterranean International Trawl Survey to investigate the potential influence of depth, seafloor temperature and seafloor dissolved oxygen on the annual biomass density and spatial distribution of whiting in the spring-summer season...

The emergence of SARS-CoV-2 variants like Delta (AY.29) and Omicron (EG.5) poses continued challenges for vaccines and therapeutics. Mutations in the viral spike protein are key in altering infectivity and immune evasion. This study uses computational modeling to investigate the molecular binding mechanisms between spike protein variants and the ACE2 host receptor. Using the MARTNI force field, coarse-grained molecular dynamics (CGMD) simulations and nudged elastic band (NEB) calculations explore spike-ACE2 interactions for the wild type, Delta variant, and Omicron variant...

The Caribbean region is prone to the strong winds and low air pressures of tropical cyclones and their corresponding storm surge that driving coastal flooding. To protect coastal communities from the impacts of tropical cyclones, it is important to understand how this impact of tropical cyclones might change towards the future. This study applies the storyline approach to show what tropical cyclones Maria (2017) and Dorian (2019) could look like in a 2 °C and 3.4 °C warmer future climate...

BACKGROUND: New variants of the virus responsible for the coronavirus disease 2019 (COVID-19) pandemic continue to emerge. However, little is known about the effect of these variants on clinical outcomes. This study evaluated the risk factors for poor pulmonary lung function test (PFT). METHODS: The study retrospectively analyzed 87 patients in a single hospital and followed up by performing PFTs at an outpatient clinic from January 2020 to December 2021. COVID-19 variants were categorized as either a non-delta variant (November 13, 2020-July 6, 2021) or the delta variant (July 7, 2021-January 29, 2022)...

Sediments are the vital fate of organic compounds, and the recognition of organic compounds in sediments is constructive in providing comprehensive and long-term information. In this study, a three-step nontarget screening (NTS) analysis workflow using comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry (GC × GC-TOFMS) revealed the extensive existence of organic compounds in the Taipu River sediment. Organic compounds (705) were detected and divided into four structure-related groups or eight use-related classes...

Black carbon (BC) exerts a profound and intricate impact on both air quality and climate due to its high light absorption. However, the uncertainty in representing the absorption enhancement of BC in climate models leads to an increased range in the modeled aerosol climate effects. Changes in BC optical properties could result either from atmospheric aging processes or from variations in its sources. In this study, a source-age model for identifying emission sources and aging states presented by University of California at Davis/California Institute of Technology (UCD/CIT) was used to simulate the atmospheric age distribution of BC from different sources and to quantify its impact on the optical properties of BC-containing particles...

People living in deltaic areas in developing countries are especially prone to suffer the effects from natural disasters due to their geographical and economic structure. Climate change is contributing to an increase in the frequency and intensity of extreme events affecting the environmental conditions of deltas, threatening the socioeconomic development of people and, eventually, triggering migration as an adaptation strategy. Climate change will likely contribute to worsening environmental stress in deltas, and understanding the relations between climate change, environmental impacts, socioeconomic conditions, and migration is emerging as a key element for planning climate adaptation...

OBJECTIVES: Mycophenolate mofetil (MMF) and azathioprine (AZA) are immunomodulatory treatments in interstitial lung disease (ILD). This systematic review aimed to evaluate the efficacy of MMF or AZA on pulmonary function in ILD. DESIGN: Population included any ILD diagnosis, intervention included MMF or AZA treatment, outcome was delta change from baseline in per cent predicted forced vital capacity (%FVC) and gas transfer (diffusion lung capacity of carbon monoxide, %DLco)...

Urban agglomerations are the centers of carbon emissions. However, research on sector-specific carbon emissions in different urban agglomerations is still limited. Drawing on the data of China's six urban agglomerations in 2005, 2010, and 2015, this study investigates the spatio-temporal patterns, regional inequalities, and driving forces of total, industrial, transportation, and residential carbon emissions. The study found that Beijing-Tianjin-Hebei was the total and sectoral emission center among the studied urban agglomerations...

OBJECTIVE: The history of airbags was reviewed for benefits and risks as they became a supplement to lap-shoulder belts. Sled and crash tests were evaluated and field data was analyzed for airbag effectiveness. Field data on airbag deaths and studies on mechanisms of deployment injury were analyzed. The history was reviewed as airbags evolved from the early 1970s to today. METHODS: Airbag benefits were determined from NHTSA crash tests with unbelted and belted dummies in 40, 48, and 56 km/h (25, 30, and 35 mph) frontal impacts with and without airbags...

The rural digital economy plays an essential role in China's industrial upgrading, transformation, and urban-rural integration. To determine the state of China's rural digital economy, we constructed a county-level evaluation system using the subjective-objective evaluation method and calculated the digital economic levels of 2085 counties. Then, we analyzed the spatial distribution characteristics, spatial autocorrelation pattern, spatial disequilibrium degree, and spatial driving force of the rural digital economy at the county level using spatial analysis technology and a self-organizing feature mapping model...

BACKGROUND AND OBJECTIVES: In SSc, ILD is a major cause of morbidity and mortality. We aimed to investigate the performance of DLCO (diffusing capacity of lung carbon monoxide) and FVC (forced vital capacity) delta change (Δ) and baseline values in predicting the development of SSc-ILD. METHODS: Longitudinal data of DLCO, FVC, and ILD on the HRCT of SSc patients from the EUSTAR database were evaluated at baseline (t0 ) and after 12 (±4) (t1 ) and 24 (±4) (t2 ) months...

Digital technology innovation is the core driving force for the high-quality development of the digital economy, and in-depth exploration of the regional distribution pattern and formation mechanism of digital technology innovation in China is conducive to the rational layout and coordinated development of the inter-provincial digital economy. Based on the Reference Relationship Table of the Classification of Core Industries of Digital Economy and the International Patent Classification (2023), the patent authorization data of digital technology from 2012 to 2022 were obtained, and the spatiotemporal situation of China's digital technology innovation was analyzed by using ArcGIS software, Dagum's Gini coefficient, and Moran's I index, and the spatial Dubin panel model was used to explore the influencing factors of digital technology innovation...

The δ opioid receptor (DOR) inverse agonist has been demonstrated to improve learning and memory impairment in mice subjected to restraint stress. Here, we investigated the effects of SYK-623, a new DOR inverse agonist, on behavioral, immunohistochemical, and biochemical abnormalities in a mouse model of imipramine treatment-resistant depression. Male ddY mice received daily treatment of adrenocorticotropic hormone (ACTH) combined with chronic mild stress exposure (ACMS). SYK-623, imipramine, or the vehicle was administered once daily before ACMS...

The coronavirus disease (COVID-19) pandemic has already affected millions of individuals, with increasing numbers of survivors. These data suggest that the pulmonary sequelae of the infection may have an effect on a wide range of individuals. The aim of the present study was to evaluate pulmonary function in patients hospitalized due to COVID-19 three months after hospital discharge. A total of 116 patients, 34 females and 82 males, with a mean age of 57.77±11.45 years, who were hospitalized due to COVID-19, underwent pulmonary function testing three months after their hospital discharge...