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https://www.readbyqxmd.com/read/27916688/effects-of-repeated-treatment-with-a-delta-opioid-receptor-agonist-knt-127-on-hyperemotionality-in-olfactory-bulbectomized-rats
#1
Leo Gotoh, Akiyoshi Saitoh, Misa Yamada, Hideaki Fujii, Hiroshi Nagase, Mitsuhiko Yamada
We previously demonstrated that a single treatment of a non-peptidic delta opioid receptor agonist, KNT-127, has an antidepressant-like effect in rodents in the forced swim test. Here we evaluated the effect of repeated administration of the potential antidepressant KNT-127 in an olfactory-bulbectomized (OBX) rat model. Male Wistar rats (8-12 weeks old) underwent olfactory bulbectomy. From 14days after surgery each was weighed and administered either KNT-127 (3mgkg(-1)/day), the selective serotonin reuptake inhibitor (SSRI) fluoxetine (10mgkg(-1)/day), or vehicle, daily for 14 days...
December 1, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27915392/sediment-suspension-and-the-dynamic-mechanism-during-storms-in-the-yellow-river-delta
#2
Shuhua Bian, Zjian Hu, Jianqiang Liu, Zichen Zhu
The suspension and hydrodynamic characteristics of the Yellow River Delta during storms were analyzed based on suspended samples obtained using automatic samplers during a storm event in the Yellow River Delta. Synchronous data for winds, waves, and tides were also collected from a nearby station. The results show that under wind speeds of 5-15 m/s and wave heights of 50-150 cm, the suspended content reached 5.7-49.6 kg/m(3), which is 10-100 times higher than that under normal weather conditions. The medium diameter of suspended particles was 1...
December 2016: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/27807273/a-new-mechanism-for-spatial-pattern-formation-via-lateral-and-protrusion-mediated-lateral-signalling
#3
Zena Hadjivasiliou, Ginger L Hunter, Buzz Baum
Tissue organization and patterning are critical during development when genetically identical cells take on different fates. Lateral signalling plays an important role in this process by helping to generate self-organized spatial patterns in an otherwise uniform collection of cells. Recent data suggest that lateral signalling can be mediated both by junctional contacts between neighbouring cells and via cellular protrusions that allow non-neighbouring cells to interact with one another at a distance. However, it remains unclear precisely how signalling mediated by these distinct types of cell-cell contact can physically contribute to the generation of complex patterns without the assistance of diffusible morphogens or pre-patterns...
November 2016: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/27734456/-opioidergic-postconditioning-of-heart-muscle-during-ischemia-reperfusion-injury
#4
Marcin Kunecki, Wojciech Płazak, Tomasz Roleder, Jolanta Biernat, Tomasz Oleksy, Piotr Podolec, Krzysztof Stanisław Gołba
BACKGROUND: Ischemic preconditioning (IPC) and postconditioning (POC) are the novel strategies of attaining cardioprotection against ischemia/reperfusion (I/R) injury. Previous studies suggested the role of opioid pathway, however the class of opioid receptors responsible for this effect in humans remains unknown. The aim of the study was to assess the influence of opioids on simulated I/R injury outcomes in the human myocardium. METHODS: Trabeculae of the human right atrium were electrically driven in organ bath and subjected to simulated I/R injury...
October 13, 2016: Cardiology Journal
https://www.readbyqxmd.com/read/27709074/correlation-of-delta-high-resolution-computed-tomography-hrct-score-with-delta-clinical-variables-in-early-systemic-sclerosis-ssc-patients
#5
Suparaporn Wangkaew, Juntima Euathrongchit, Pittaporn Wattanawittawas, Nuntana Kasitanon
BACKGROUND: The correlation of changes (delta: Δ) of high-resolution computed tomography (HRCT) score with the Δ of other clinical variables has not been well studied. The purpose of this study was to determine the correlation of Δ HRCT score with Δ percent predicted forced vital capacity (%pFVC), Δ modified Rodnan Skin Score (mRSS), Δ erythrocyte sedimentation rate (ESR), and Δ percent of oxygen saturation at room air (%SpO2) in patients with early systemic sclerosis (SSc). METHODS: We used an inception cohort of early-SSc patients seen at the Rheumatology Clinic, Chiang Mai University, Thailand, between January 2010 and June 2014...
August 2016: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/27684742/production-of-materials-with-spatially-controlled-cross-link-density-via-vat-photopolymerization
#6
Gregory I Peterson, Johanna J Schwartz, Di Zhang, Benjamin M Weiss, Mark A Ganter, Duane W Storti, Andrew J Boydston
We describe an efficient method to produce objects comprising spatially controlled and graded cross-link densities using vat photopolymerization additive manufacturing (AM). Using a commercially available diacrylate-based photoresin, 3D printer, and digital light processing (DLP) projector, we projected grayscale images to print objects in which the varied light intensity was correlated to controlled cross-link densities and associated mechanical properties. Cylinder and bar test specimens were used to establish correlations between light intensities used for printing and cross-link density in the resulting specimens...
October 11, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27624599/the-role-of-regulator-of-g-protein-signaling-4-in-delta-opioid-receptor-mediated-behaviors
#7
Isaac J Dripps, Qin Wang, Richard R Neubig, Kenner C Rice, John R Traynor, Emily M Jutkiewicz
RATIONALE: Regulator of G protein signaling (RGS) proteins act as negative modulators of G protein signaling. RGS4 has been shown to negatively modulate G protein signaling mediated by the delta opioid receptor (DOPr) in vitro. However, the role of RGS4 in modulating DOPr-mediated behaviors in vivo has not been elucidated. OBJECTIVE: The aim of this study was to compare the ability of the DOPr agonist SNC80 to induce DOPr-mediated antinociception, antihyperalgesia, antidepressant-like effects, and convulsions in wild-type and RGS4 knockout mice...
September 13, 2016: Psychopharmacology
https://www.readbyqxmd.com/read/27591356/human-kinetochores-are-swivel-joints-that-mediate-microtubule-attachments
#8
Chris A Smith, Andrew D McAinsh, Nigel J Burroughs
Chromosome segregation is a mechanical process that requires assembly of the mitotic spindle - a dynamic microtubule-based force-generating machine. Connections to this spindle are mediated by sister kinetochore pairs, that form dynamic end-on attachments to microtubules emanating from opposite spindle poles. This bi-orientation generates forces that have been reported to stretch the kinetochore itself, which has been suggested to stabilise attachment and silence the spindle checkpoint. We reveal using three dimensional tracking that the outer kinetochore domain can swivel around the inner kinetochore/centromere, which results in large reductions in intra-kinetochore distance (delta) when viewed in lower dimensions...
September 3, 2016: ELife
https://www.readbyqxmd.com/read/27549033/high-time-resolved-elemental-components-in-fine-and-coarse-particles-in-the-pearl-river-delta-region-of-southern-china-dynamic-variations-and-effects-of-meteorology
#9
Shengzhen Zhou, Perry K Davy, Xuemei Wang, Jason Blake Cohen, Jiaquan Liang, Minjuan Huang, Qi Fan, Weihua Chen, Ming Chang, Travis Ancelet, William J Trompetter
Hourly-resolved PM2.5 and PM10-2.5 samples were collected in the industrial city Foshan in the Pearl River Delta region, China. The samples were subsequently analyzed for elemental components and black carbon (BC). A key purpose of the study was to understand the composition of particulate matter (PM) at high-time resolution in a polluted urban atmosphere to identify key components contributing to extreme PM concentration events and examine the diurnal chemical concentration patterns for air quality management purposes...
August 20, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27468593/the-effect-of-benzocaine-and-ketoprofen-gels-on-pain-during-fixed-orthodontic-appliance-treatment-a-randomised-double-blind-crossover-trial
#10
RANDOMIZED CONTROLLED TRIAL
Ladan Eslamian, Ali Borzabadi-Farahani, Hadi Gholami
AIMS: To compare the analgesic effect of topical benzocaine (5%) and ketoprofen (1.60 mg/mL) after 2 mm activation of 7 mm long delta loops used for maxillary en-masse orthodontic space closure. SUBJECTS AND METHODS: Twenty patients (seven males, 13 females, 15-25 years of age, mean age of 19.5 years) participated in a randomised crossover, double-blind trial. After appliance activation, participants were instructed to use analgesic gels and record pain perception at 2, 6, 24 hours and 2, 3 and 7 days (at 18...
May 2016: Australian Orthodontic Journal
https://www.readbyqxmd.com/read/27456840/the-effects-of-helmet-weight-on-hybrid-iii-head-and-neck-responses-by-comparing-unhelmeted-and-helmeted-impacts
#11
Ron Jadischke, David C Viano, Joe McCarthy, Albert I King
Most studies on football helmet performance focus on lowering head acceleration-related parameters to reduce concussions. This has resulted in an increase in helmet size and mass. The objective of this paper was to study the effect of helmet mass on head and upper neck responses. Two independent test series were conducted. In test series one, 90 pendulum impact tests were conducted with four different headform and helmet conditions: unhelmeted Hybrid III headform, Hybrid III headform with a football helmet shell, Hybrid III headform with helmet shell and facemask, and Hybrid III headform with the helmet and facemask with mass added to the shell (n = 90)...
October 1, 2016: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/27448348/dyadic-universal-functions-and-simultaneous-near-field-far-field-regularization-of-elastodynamic-dyadic-green-s-functions-for-3-d-mass-loading-analysis-in-microacoustic-devices
#12
Alireza Baghai-Wadji
Assuming an infinite-domain isotropic elastic medium and a Dirac delta function vector-force excitation, [Formula: see text], spectral domain dyadic Green's functions (DGFs) G for 3-D mass-loading analysis in microacoustic devices have been constructed. Thereby, equivalent inhomogeneous plane-wave (2-D Fourier transform) and homogeneous plane-wave (3-D Fourier transform) representations, G(k1,k2) and G(k1,k2,k3) , respectively, have been obtained in closed form. The construction of G(k1,k2) follows an earlier scheme by utilizing the diagonalization of the governing equations subject to the radiation condition...
October 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/27385703/stability-of-dronabinol-capsules-when-stored-frozen-refrigerated-or-at-room-temperature
#13
Michael F Wempe, Alan Oldland, Nancy Stolpman, Tyree H Kiser
PURPOSE: Results of a study to determine the 90-day stability of dronabinol capsules stored under various temperature conditions are reported. METHODS: High-performance liquid chromatography (HPLC) with ultraviolet (UV) detection was used to assess the stability of dronabinol capsules (synthetic delta-9-tetrahydrocannabinol [Δ9-THC] mixed with high-grade sesame oil and other inactive ingredients and encapsulated as soft gelatin capsules) that were frozen, refrigerated, or kept at room temperature for three months...
July 15, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27375969/shapes-of-leaves-with-parallel-venation-modelling-of-the-epipactis-sp-orchidaceae-leaves-with-the-help-of-a-system-of-coupled-elastic-beams
#14
Anna Jakubska-Busse, Maciej Janowicz, Luiza Ochnio, Beata Jackowska-Zduniak
Static properties of leaves with parallel venation, with particular emphasis on the genus EpipactisZinn, 1757 (Orchidaceae, Neottieae) have been modelled with coupled quasi-parallel elastic "beams." The non-linear theory of strongly bended beams have been employed. The resulting boundary-value problem has been solved numerically with the help of the finite-difference method. Possible dislocations resulting in additional Dirac-delta like forces have been take into account. Morphological similarity of the model and real leaves has been obtained...
2016: PeerJ
https://www.readbyqxmd.com/read/27300441/-the-pitch-angle-of-a-locked-plate-osteosynthesis-construct
#15
S Döbele, O Erne, S Ehnert, U Stöckle, T Freude, F Stuby
UNLABELLED: The aim of the present study is to describe the biomechanical properties of the fracture motion of a locked plate construct. METHOD: The three dimensional fracture motion of a conventional and of a dynamic locked plate construct was observed using an optical measurement system. RESULTS: Fracture motion was described in terms of delta z (mean fracture motion in direction of force application) and the pitch angle (angle between the upper and lower cylinders of osteosynthesis)...
August 2016: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/27291389/-italian-cystic-fibrosis-register-report-2010
#16
Annalisa Amato, Luigina Ferrigno, Marco Salvatore, Virgilia Toccaceli
UNLABELLED: The Italian National CF Registry (INCFR) is based on the official agreement between the clinicians of the Italian National Referral Centers for Cystic Fibrosis and the researchers of the Istituto Superiore di Sanità (National Center for Rare Diseases; National Center for Epidemiology, Surveillance and Health Care Promotion). OBJECTIVES The main aim of INCFR is to contribute to the improvement in CF patients health care and clinical management through: i. the estimates of CF prevalence and incidence in Italy; ii...
March 2016: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/27285295/which-amount-of-bmi-sds-reduction-is-necessary-to-improve-cardiovascular-risk-factors-in-overweight-children
#17
Thomas Reinehr, Nina Lass, Christina Toschke, Juliane Rothermel, Stefanie Lanzinger, Reinhard W Holl
CONTEXT: Knowing the changes of cardiovascular risk factors (CRFs) in relation to weight loss would be helpful to advise overweight children and their parents and to decide whether drugs should be prescribed in addition to lifestyle intervention. OBJECTIVE: The objective of the study was to determine the body mass index (BMI)-SD score (SDS) reduction to improve CRFs in overweight children. DESIGN: This was a prospective observation study. SETTING: The study was conducted at a specialized outpatient obesity clinic...
August 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27264889/dynamics-of-thermographic-skin-temperature-response-during-squat-exercise-at-two-different-speeds
#18
Damiano Formenti, Nicola Ludwig, Athos Trecroci, Marco Gargano, Giovanni Michielon, Andrea Caumo, Giampietro Alberti
Low intensity resistance training with slow movement and tonic force generation has been shown to create blood flow restriction within muscles that may affect thermoregulation through the skin. We aimed to investigate the influence of two speeds of exercise execution on skin temperature dynamics using infrared thermography. Thirteen active males performed randomly two sessions of squat exercise (normal speed, 1s eccentric/1s concentric phase, 1s; slow speed, 5s eccentric/5s concentric phase, 5s), using ~50% of 1 maximal repetition...
July 2016: Journal of Thermal Biology
https://www.readbyqxmd.com/read/27260566/small-female-ribcage-fracture-in-frontal-sled-tests
#19
Greg Shaw, David Lessley, Joseph Ash, Jerry Poplin, Tim McMurry, Mark Sochor, Jeff Crandall
OBJECTIVES: The two objectives of this study are to 1) examine the rib and sternal fractures sustained by small stature elderly females in simulated frontal crashes and 2) determine how the findings are characterized by prior knowledge and field data. METHODS: A test series was conducted to evaluate the response of five elderly (average age 76 years) female PMHS subjects, similar in mass and size to a 5th percentile female, in 30 km/h frontal sled tests. The subjects were restrained on a rigid planar seat by bilateral rigid knee bolsters, pelvic blocks, and a custom force-limited three-point shoulder and lap belt...
June 3, 2016: Traffic Injury Prevention
https://www.readbyqxmd.com/read/27234827/column-integrated-aerosol-optical-properties-and-direct-radiative-forcing-over-the-urban-industrial-megacity-nanjing-in-the-yangtze-river-delta-china
#20
Na Kang, K Raghavendra Kumar, Xingna Yu, Yan Yin
Aerosol optical properties were measured and analyzed through the ground-based remote sensing Aerosol Robotic Network (AERONET) over an urban-industrial site, Nanjing (32.21° N, 118.72° E, and 62 m above sea level), in the Yangtze River Delta, China, during September 2007-August 2008. The annual averaged values of aerosol optical depth (AOD500) and the Ångström exponent (AE440-870) were measured to be 0.94 ± 0.52 and 1.10 ± 0.21, respectively. The seasonal averaged values of AOD500 (AE440-870) were noticed to be high in summer (autumn) and low in autumn (spring)...
September 2016: Environmental Science and Pollution Research International
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