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https://www.readbyqxmd.com/read/29789592/allogenic-and-autogenic-signals-in-the-stratigraphic-record-of-the-deep-sea-bengal-fan
#1
Mike Blum, Kimberly Rogers, James Gleason, Yani Najman, Jarrett Cruz, Lyndsey Fox
The Himalayan-sourced Ganges-Brahmaputra river system and the deep-sea Bengal Fan represent Earth's largest sediment-dispersal system. Here we present detrital zircon U-Pb provenance data from Miocene to middle Pleistocene Bengal Fan turbidites, and evaluate the influence of allogenic forcing vs. autogenic processes on signal propagation from the Himalaya to the deep sea. Our data record the strong tectonic and climatic forcing characteristic of the Himalayan system: after up to 2500 km of river transport, and >1400 km of transport by turbidity currents, the U-Pb record faithfully represents Himalayan sources...
May 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29789250/sectioning-of-the-anterior-intermeniscal-ligament-changes-knee-loading-mechanics
#2
Matthieu Ollivier, Julie Falguières, Martine Pithioux, Philippe Boisrenoult, Phillippe Beaufils, Nicolas Pujol
PURPOSE: The purpose of this cadaver research project was to describe the biomechanical consequences of anterior intermeniscal ligament (AIML) resection on menisci function under load conditions in full extension and 60° of flexion. METHODS: Ten unpaired fresh frozen cadaveric knees were dissected leaving the knee joint intact with its capsular and ligamentous attachments. The femur and tibia were sectioned 15 cm from the joint line and mounted onto the loading platform...
May 19, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29778667/cardiovascular-risk-factors-is-the-metabolic-syndrome-related-to-aging-epidemiology-in-a-portuguese-population
#3
Armindo Sousa Ribeiro, Rui Seixas, Juan Manuel Gálvez, Vicente Climent
AIMS: The primary objective of our study is to determine the prevalence of the metabolic syndrome in the population. The secondary objective is to determine the prevalence of cardiovascular risk factors, anthropometric alterations and the prevalence of target organ damage and their relationship with aging. MATERIAL AND METHODS: The sample for the study was obtained by means of a consecutive population-based demonstration in 803 adults over 18 years of age belonging to the labor force of the company Grupo Delta SA...
May 16, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29778658/marijuana-and-lung-disease
#4
REVIEW
Donald P Tashkin
As marijuana smoking prevalence increases in the U.S. concern regarding its potential risks to lung health has also risen, given the general similarity in the smoke contents between marijuana and tobacco. Most studies have found a significant association between marijuana smoking and chronic bronchitis symptoms after adjustment for tobacco. While reports are mixed regarding associations between marijuana smoking and lung function, none has shown a relationship to decrements in forced expired volume in 1 sec (FEV1) and few have found a relationship to a decreased ratio of FEV1 to forced vital capacity (FVC), possibly related to an association between marijuana and an increased FVC...
May 17, 2018: Chest
https://www.readbyqxmd.com/read/29773448/the-role-of-the-common-gamma-chain-family-cytokines-in-%C3%AE-%C3%AE-t-cell-based-anti-cancer-immunotherapy
#5
REVIEW
Heleen H Van Acker, Diana Campillo-Davo, Gils Roex, Maarten Versteven, Evelien L Smits, Viggo F Van Tendeloo
Cytokines of the common gamma-chain receptor family, comprising interleukin (IL)-2, IL-4, IL-7, IL-9, IL-15 and IL-21, are vital with respect to organizing and sustaining healthy immune cell functions. Supporting the anti-cancer immune response, these cytokines inspire great interest for their use as vaccine adjuvants and cancer immunotherapies. It is against this background that gamma delta (γδ) T cells, as special-force soldiers and natural contributors of the tumor immunosurveillance, also received a lot of attention the last decade...
May 14, 2018: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/29758428/threats-to-coastal-communities-of-mahanadi-delta-due-to-imminent-consequences-of-erosion-present-and-near-future
#6
Anirban Mukhopadhyay, Pramit Ghosh, Abhra Chanda, Amit Ghosh, Subhajit Ghosh, Shouvik Das, Tuhin Ghosh, Sugata Hazra
Coastal erosion is a natural hazard which causes significant loss to properties as well as coastal habitats. Coastal districts of Mahanadi delta, one of the most populated deltas of the Indian subcontinent, are suffering from the ill effects of coastal erosion. An important amount of assets is being lost every year along with forced migration of huge portions of coastal communities due to erosion. An attempt has been made in this study to predict the future coastline of the Mahanadi Delta based on historical trends...
May 11, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29747413/binding-of-catechins-to-staphylococcal-enterotoxin-a
#7
Yuko Shimamura, Mio Utsumi, Chikako Hirai, Shogo Nakano, Sohei Ito, Ai Tsuji, Takeshi Ishii, Takahiro Hosoya, Toshiyuki Kan, Norio Ohashi, Shuichi Masuda
Staphylococcal enterotoxin A (SEA) is a toxin protein, and is the most common cause of staphylococcal food poisoning. Polyphenols, such as catechins, are known to interact with proteins. In this study, we investigated the binding of catechins to SEA using SPR (Biacore), Fourier transform infrared spectroscopy (FT-IR), isothermal titration calorimetry (ITC), and protein-ligand docking. We found that (−)-epigallocatechin gallate (EGCG) could strongly bind to SEA. According to thermodynamic parameters, a negative Δ G indicated that the interaction between EGCG and SEA was spontaneous, and the electrostatic force accompanied by hydrophobic binding forces may play a major role in the binding...
May 9, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29713059/inactivation-of-the-serine-protease-htra1-inhibits-tumor-growth-by-deregulating-angiogenesis
#8
Ralph Klose, M Gordian Adam, Eva-Maria Weis, Iris Moll, Joycelyn Wüstehube-Lausch, Fabian Tetzlaff, Chio Oka, Michael Ehrmann, Andreas Fischer
The serine protease HTRA1 is involved in several vascular diseases and its expression is often deregulated in cancer. We aimed at identifying how HTRA1 in the vasculature affects tumor growth. Here we report that silencing of HTRA1 in cultured endothelial cells increased migration rate and tube formation, whereas forced HTRA1 expression impaired sprouting angiogenesis. Mechanistically, endothelial HTRA1 expression enhanced Delta/Notch signaling by reducing the amount of the weak Notch ligand JAG1. HTRA1 physically interacted with JAG1 and cleaved it within the intracellular domain, leading to protein degradation...
May 1, 2018: Oncogene
https://www.readbyqxmd.com/read/29710613/heavy-metal-loid-s-and-organic-contaminants-in-groundwater-in-the-pearl-river-delta-that-has-undergone-three-decades-of-urbanization-and-industrialization-distributions-sources-and-driving-forces
#9
Guanxing Huang, Ming Zhang, Chunyan Liu, Liangping Li, Zongyu Chen
Urbanization and industrialization have increased groundwater resource demands, and may drive the change of heavy metal(loid)s and organic chemicals in groundwater in the Pearl River Delta (PRD), southern China. Thus, a comprehensive understanding of the distributions, sources, and driving forces of heavy metal(loid)s and organic chemicals in groundwater in the PRD is vital for water resource management in this region. In this study, eight heavy metal(loid)s and fifty-five organic chemicals in groundwater across the PRD were investigated...
April 20, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29691043/numerical-simulations-for-the-sources-apportionment-and-control-strategies-of-pm-2-5-over-pearl-river-delta-china-part-i-inventory-and-pm-2-5-sources-apportionment
#10
Yeqi Huang, Tao Deng, Zhenning Li, Nan Wang, Chanqin Yin, Shiqiang Wang, Shaojia Fan
This article uses the WRF-CMAQ model to systematically study the source apportionment of PM2.5 under typical meteorological conditions in the dry season (November 2010) in the Pearl River Delta (PRD). According to the geographical location and the relative magnitude of pollutant emission, Guangdong Province is divided into eight subdomains for source apportionment study. The Brute-Force Method (BFM) method was implemented to simulate the contribution from different regions to the PM2.5 pollution in the PRD...
April 21, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29680533/tracking-plastics-in-the-mediterranean-2d-lagrangian-model
#11
S Liubartseva, G Coppini, R Lecci, E Clementi
Drift of floating debris is studied with a 2D Lagrangian model with stochastic beaching and sedimentation of plastics. An ensemble of >1010 virtual particles is tracked from anthropogenic sources (coastal human populations, rivers, shipping lanes) to environmental destinations (sea surface, coastlines, seabed). Daily analyses of ocean currents and waves provided by CMEMS at a horizontal resolution of 1/16° are used to force the plastics. High spatio-temporal variability in sea-surface plastic concentrations without any stable long-term accumulations is found...
April 2018: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/29679256/biomechanical-features-of-six-design-of-the-delta-external-fixator-for-treating-pilon-fracture-a-finite-element-study
#12
Muhammad Hanif Ramlee, Mohd Ayub Sulong, Evelyn Garcia-Nieto, Daniel Angure Penaranda, Antonio Ros Felip, Mohammed Rafiq Abdul Kadir
Pilon fractures can be caused by high-energy vertical forces which may result in long-term patient immobilization. Many experts in orthopedic surgery recommend the use of a Delta external fixator for type III Pilon fracture treatment. This device can promote immediate healing of fractured bone, minimizing the rate of complications as well as allowing early mobilization. The characteristics of different types of the Delta frame have not been demonstrated yet. By using the finite element method, this study was conducted to determine the biomechanical characteristics of six different configurations (Model 1 until Model 6)...
April 21, 2018: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29653296/the-role-of-resting-state-eeg-localized-activation-and-central-nervous-system-arousal-in-executive-function-performance-in-children-with-attention-deficit-hyperactivity-disorder
#13
Da-Wei Zhang, Stuart J Johnstone, Steven Roodenrys, Xiangsheng Luo, Hui Li, Encong Wang, Qihua Zhao, Yan Song, Lu Liu, Qiujin Qian, Yufeng Wang, Li Sun
OBJECTIVE: This study explored the relationships between resting-state electroencephalogram (RS-EEG) localized activation and two important types of executive functions (EF) to extend the prognostic utilization of RS-EEG in children with Attention-Deficit/Hyperactivity Disorder (AD/HD). Also, the role of central nervous system (CNS) arousal in the relationships was examined. METHODS: Fifty-eight children with AD/HD participated in the study. RS-EEG localized activation was derived from spectral power differences between EEG in eyes-closed and eyes-open conditions...
March 30, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29653140/in-vitro-mechanical-stimulation-facilitates-stress-dissipation-and-sealing-ability-at-the-conventional-glass-ionomer-cement-dentin-interface
#14
Manuel Toledano, Raquel Osorio, Estrella Osorio, Inmaculada Cabello, Manuel Toledano-Osorio, Fátima S Aguilera
OBJECTIVE: The aim of this study was to evaluate the induced changes in the chemical and mechanical performance at the glass-ionomer cement-dentin interface after mechanical load application. METHODS: A conventional glass-ionomer cement (GIC) (Ketac Bond), and a resin-modified glass-ionomer cement (RMGIC) (Vitrebond Plus) were used. Bonded interfaces were stored in simulated body fluid, and then tested or submitted to the mechanical loading challenge. Different loading waveforms were applied: No cycling, 24 h cycled in sine or loaded in sustained hold waveforms...
April 10, 2018: Journal of Dentistry
https://www.readbyqxmd.com/read/29643895/expression-analysis-of-glyoxalase-i-gene-among-patients-of-diabetic-retinopathy
#15
Aneela Rasul, Amir Rashid, Palvasha Waheed, Saleem Ahmed Khan
Objectives: To study expression of glyoxalase I in patients of diabetic retinopathy. Methods: This cross-sectional comparative study was conducted at Centre for Research in Experimental and Applied Medicine (CREAM), Department of Biochemistry and Molecular Biology, Army Medical College, Rawalpindi in collaboration with Armed Forces Institute of Ophthalmology (AFIO) from January 2015 to November 2015. Sampling technique was non- probability purposive sampling. Total 60 subjects were enrolled in two groups...
January 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29604516/market-penetration-of-intersection-aeb-characterizing-avoided-and-residual-straight-crossing-path-accidents
#16
Ulrich Sander, Nils Lubbe
Car occupants account for one third of all junction fatalities in the European Union. Driver warning can reduce intersection accidents by up to 50 percent; adding Autonomous Emergency Braking (AEB) delivers a reduction of up to 70 percent. However, these findings are based on an assumed 100 percent equipment rate, which may take decades to achieve. Our study investigates the relationship between intersection AEB market penetration rates and avoidance of accidents and injuries in order to guide implementation strategies...
March 28, 2018: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29584505/a-preliminary-study-of-human-model-head-and-neck-response-to-frontal-loading-in-nontraditional-occupant-seating-configurations
#17
F S Gayzik, B Koya, M L Davis
OBJECTIVE: Computational human body models (HBMs) are nominally omnidirectional surrogates given their structural basis in human anatomy. As a result, such models are well suited for studies related to occupant safety in anticipated highly automated vehicles (HAVs). We utilize a well-validated HBM to study the head and neck kinematics in simulations of nontraditional occupant seating configurations. METHODS: The GHBMC M50-O v. 4.4 HBM was gravity settled into a generic seat buck and situated in a seated posture...
February 28, 2018: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29584498/the-influence-of-child-restraint-lower-attachment-method-on-protection-offered-by-forward-facing-child-restraint-systems-in-oblique-loading-conditions
#18
Hans W Hauschild, John R Humm, Frank A Pintar, Narayan Yoganandan, Bruce Kaufman, Matthew R Maltese, Kristy B Arbogast
OBJECTIVE: The research objective was to quantify the influence of child restraint lower attachment method on head kinematics, head impact potential, and head, neck, and thorax injury metrics for a child occupant secured in a forward-facing child restraint system (FFCRS) in oblique side impacts. METHODS: Fifteen sled tests were conducted with a Q3s seated in an FFCRS secured to the center position on a production small SUV bench seat. Three lower attachment methods were evaluated: rigid ISOFIX, a flexible single loop lower anchors and tethers for children (LATCH) webbing routed through the vehicle belt path of the FFCRS, and dual flexible LATCH webbing attachments on either side of the FFCRS...
February 28, 2018: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29506377/-italian-cystic-fibrosis-registry-report-2011-2014
#19
Barbara Giordani, Annalisa Amato, Fabio Majo, Gianluca Ferrari, Serena Quattrucci, Laura Minicucci, Rita Padoan, Giovanna Floridia, Gianna Puppo Fornaro, Domenica Taruscio, Marco Salvatore
INTRODUCTION: The Italian Cystic Fibrosis Registry (ICFR) is based on a new agreement about the data flow towards the Registry signed on October, 4th 2016 by the Centre for Rare Diseases of the Italian National Institute of Health (NIH), the clinicians of the Italian National Referral and Support Centres for Cystic Fibrosis, the Paediatric Hospital "Bambino Gesù" (Rome), the Italian Cystic Fibrosis Society, and the Italian League for Cystic Fibrosis. OBJECTIVES: The aim of the present Report is to improve the knowledge on cystic fibrosis (CF) through the epidemiological description of Italian patients...
January 2018: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/29479634/coordination-of-plantar-flexor-muscles-during-bipedal-and-unipedal-stances-in-young-and-elderly-adults
#20
Tatsunori Watanabe, Kotaro Saito, Kazuto Ishida, Shigeo Tanabe, Ippei Nojima
To investigate the effects of aging on coordination of plantar flexor muscles during bipedal and unipedal stances, we examined a relationship between the center of pressure sway and electromyographic activity of these muscles, and also the common neural input, using a coherence analysis. Healthy young and elderly adults were asked to perform bipedal and unipedal standing. The electromyograms were recorded unilaterally from the medial and lateral gastrocnemius (MG and LG) and soleus (SL) muscles, and the common input was analyzed for MG-LG, MG-SL, and LG-SL pairs in two frequency bands: a delta band, that is associated with force variability, and a beta band, that could reflect the corticospinal drive...
May 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
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