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https://www.readbyqxmd.com/read/28930164/liver-cancer-molecular-characterization-clonal-evolution-and-cancer-stem-cells
#1
REVIEW
Germana Castelli, Elvira Pelosi, Ugo Testa
Liver cancer is the second most common cause of cancer-related death. The major forms of primary liver cancer are hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA). Both these tumors develop against a background of cirrhotic liver, non-alcoholic fatty liver disease, chronic liver damage and fibrosis. HCC is a heterogeneous disease which usually develops within liver cirrhosis related to various etiologies: hepatitis B virus (HBV) infection (frequent in Asia and Africa), hepatitis C virus (HCV), chronic alcohol abuse, or metabolic syndrome (frequent in Western countries)...
September 20, 2017: Cancers
https://www.readbyqxmd.com/read/28927099/interleukin-6-identified-as-an-important-factor-in-hypoxia-and-aldehyde-dehydrogenase-based-gefitinib-adaptive-resistance-in-non-small-cell-lung-cancer-cells
#2
Shi-Min An, Hui-Min Lei, Xu-Ping Ding, Fan Sun, Chun Zhang, Ya-Bin Tang, Hong-Zhuan Chen, Ying Shen, Liang Zhu
Gefitinib resistance and relapse of the disease were the greatest challenges facing clinical therapy of non-small-cell lung cancer (NSCLC). Of note, regarding the hypoxia condition in solid tumor tissues in vivo, roles of hypoxia in gefitinib adaptive resistance and its association with lung cancer stem cells (LCSCs) have not been fully elucidated. In the present study, the role of hypoxia in gefitinib adaptive resistance and its association with aldehyde dehydrogenase (ALDH)-based LCSC gefitinib resistance were comparatively studied using RNA-sequencing (RNA-seq) technology...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28922758/the-role-of-arabidopsis-aldehyde-dehydrogenase-genes-in-response-to-high-temperature-and-stress-combinations
#3
Junyi Zhao, Tagnon D Missihoun, Dorothea Bartels
Aldehyde dehydrogenases (ALDH) are a family of enzymes that are involved in plant metabolism and contribute to aldehyde homeostasis to eliminate toxic aldehydes. The ALDH enzymes produce NADPH and NADH in their enzymatic reactions and thus contribute to balancing redox equivalents. Previous studies showed that Arabidopsis ALDH genes are expressed in response to high salinity, dehydration, oxidative stress, or heavy metals, suggesting important roles in environmental adaptation. However, the role of ALDH genes in high temperature and stress combinations (heat stress combined with dehydration, wounding, or salt stress) is unclear...
July 10, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28912842/a-reliable-method-for-the-sorting-and-identification-of-aldh-high-cancer-stem-cells-by-flow-cytometry
#4
Zhengwei Leng, Zhao Yang, Lifa Li, Xiaorong Zhong, He Zhou, Yong Li, Gang Yang, Guangjun Zhang, Yongfu Xiong, Tong Zhou, Jianshui Li, Dongsheng Wang, Jingdong Li
Cancer stem cells (CSCs) are a rare tumorigenic population of cells found in multiple types of cancer. It has been suggested that CSCs are responsible for cancer drug resistance, metastasis and recurrence. Therefore, it is important to develop techniques to correctly sort and identify CSCs. In the current study, the sorting and identification of aldehyde dehydrogenase high (ALDH(high)) CSCs was performed using flow cytometry. Cells from three colon cancer cell lines were cultured in serum-free medium to obtain CSCs-enriched spheroid cells...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28912540/sox9-regulates-cancer-stem-like-properties-and-metastatic-potential-of-single-walled-carbon-nanotube-exposed-cells
#5
Maria A Voronkova, Sudjit Luanpitpong, Liying Wang Rojanasakul, Vincent Castranova, Cerasela Zoica Dinu, Heimo Riedel, Yon Rojanasakul
Engineered nanomaterials hold great promise for the future development of innovative products but their adverse health effects are a major concern. Recent studies have indicated that certain nanomaterials, including carbon nanotubes (CNTs), may be carcinogenic. However, the underlying mechanisms behind their potential malignant properties remain unclear. In this study, we linked SOX9, a stem cell associated transcription factor, to the neoplastic-like properties of human lung epithelial cells chronically exposed to a low-dose of single-walled carbon nanotubes (SWCNTs)...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28911673/impact-of-different-partitioned-solvents-on-chemical-composition-and-bioavailability-of-sasa-quelpaertensis-nakai-leaf-extract
#6
Masaya Nakamura, Jong-Hwan Ra, Youngheun Jee, Ju-Sung Kim
The leaves of Sasa quelpaertensis Nakai were extracted with 80% ethanol and further partitioned with n-hexane, chloroform, ethyl acetate, n-butanol, and aqueous fractions to evaluate the biological activity through assessment via various in vitro assays, including total phenol content; 1,1-diphenyl-1-picrylhydrazyl (DPPH) and 2,2-azino-bis-(3-ethylbenzothiazothiazoline-6-sulfornic acid (ABTS) radical scavenging; reducing power; α-glucosidase and tyrosinase inhibitory; and alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) activity assays...
April 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28903537/evolutionary-origins-of-pax6-control-of-crystallin-genes
#7
Ales Cvekl, Yilin Zhao, Rebecca McGreal, Qing Xie, Xun Gu, Deyou Zheng
The birth of novel genes, including their cell-specific transcriptional control, is a major source of evolutionary innovation. The lens-preferred proteins, crystallins (vertebrates: α- and β/γ-crystallins), provide a gateway to study eye evolution. Diversity of crystallins was thought to originate from convergent evolution through multiple, independent formation of Pax6/PaxB-binding sites within the promoters of genes able to act as crystallins. Here, we propose that αB-crystallin arose from a duplication of small heat shock protein (Hspb1-like) gene accompanied by Pax6-site and heat shock element (HSE) formation, followed by another duplication to generate the αA-crystallin gene in which HSE was converted into another Pax6-binding site...
August 1, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28903500/intrinsic-xenobiotic-metabolizing-enzyme-activities-in-early-life-stages-of-zebrafish-danio-rerio
#8
Jens C Otte, Bernadette Schultz, Daniela Fruth, Eric Fabian, Bennard van Ravenzwaay, Björn Hidding, Edward R Salinas
Early life stages of zebrafish (Danio rerio, zf) are gaining attention as an alternative invivo test system for drug discovery, early developmental toxicity screenings and chemical testing in ecotoxicological and toxicological testing strategies. Previous studies have demonstrated transcriptional evidence for xenobiotic metabolizing enzymes (XME) during early zf development. However, elaborate experiments on XME activities during development are incomplete. In this work, the intrinsic activities of representative phase I and II XME were monitored by transformation of putative zf model substrates analyzed using photometry and high pressure liquid chromatography techniques...
September 1, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28890346/hepatoprotective-effects-of-methyl-ferulic-acid-on-alcohol-induced-liver-oxidative-injury-in-mice-by-inhibiting-the-nox4-ros-mapk-pathway
#9
Chen Li, Li Li, Cheng-Fang Yang, Yu-Juan Zhong, Dan Wu, Lin Shi, Li Chen, Yong-Wen Li
AIMS: The present study aimed to investigate the hepatoprotective effects of Methyl ferulic acid (MFA) against oxidative stress and apoptosis as well as inflammation in mice with liver injury induced by alcohol and its underlying mechanisms. METHODS: C57BL/6 mice were divided into a control group,a model group, and Methyl ferulic acid with high dosage (20 mg/kg), moderate dosage (10 mg/kg) and low dosage (5 mg/kg) groups. The general condition and organ index of each group were investigated...
September 7, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28890241/manual-and-expert-annotation-of-the-nearly-complete-genome-sequence-of-staphylococcus-sciuri-strain-atcc-29059-a-reference-for-the-oxidase-positive-staphylococci-that-supports-the-atypical-phenotypic-features-of-the-species-group
#10
Eugene Christo-Foroux, Tatiana Vallaeys, Valentin Loux, Elie Dassa, Josef Deutscher, Cécile Wandersman, Aurélien Livernois, Chloe Hot, Alexis Criscuolo, Catherine Dauga, Dominique Clermont, Olivier Chesneau
Staphylococcus sciuri is considered to be one of the most ancestral species in the natural history of the Staphylococcus genus that consists of 48 validly described species. It belongs to the basal group of oxidase-positive and novobiocin-resistant staphylococci that diverged from macrococci approximately 250 million years ago. Contrary to other groups, the S. sciuri species group has not developed host-specific colonization strategies. Genome analysis of S. sciuri ATCC 29059 provides here the first genetic basis for atypical traits that would support the switch between the free-living style and the infective state in animals and humans...
August 24, 2017: Systematic and Applied Microbiology
https://www.readbyqxmd.com/read/28889122/galectin-9-produced-by-intestinal-epithelial-cells-enhances-aldehyde-dehydrogenase-activity-in-dendritic-cells-in-a-pi3k-and-p38-dependent-manner
#11
Sander de Kivit, Atanaska I Kostadinova, JoAnn Kerperien, Veronica Ayechu Muruzabal, Mary E Morgan, Leon M J Knippels, Aletta D Kraneveld, Johan Garssen, Linette E M Willemsen
Intestinal epithelial cells (IEC) drive regulatory T cell (Treg) responses by promoting the differentiation of aldehyde dehydrogenase (ALDH)-expressing CD103+ dendritic cells (DC). Apical stimulation of TLR9 by CpG DNA on IEC supports galectin-9 expression by IEC, which is promoted by short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides (GF). While galectin-9 can induce the maturation of monocyte-derived DC (moDC), the contribution of galectin-9 on the induction of ALDH activity in DC is not known...
September 9, 2017: Journal of Innate Immunity
https://www.readbyqxmd.com/read/28881734/targeting-aldehyde-dehydrogenase-activity-in-head-and-neck-squamous-cell-carcinoma-with-a-novel-small-molecule-inhibitor
#12
Jeewon Kim, June Ho Shin, Che-Hong Chen, Leslie Cruz, Lovisa Farnebo, Jieying Yang, Paula Borges, Gugene Kang, Daria Mochly-Rosen, John B Sunwoo
Chemoresistant cancer cells express high levels of aldehyde dehydrogenases (ALDHs), particularly in head and neck squamous cell carcinoma (HNSCC). The ALDH family of enzymes detoxify both exogenous and endogenous aldehydes. Since many chemotherapeutic agents, such as cisplatin, result in the generation of cytotoxic aldehydes and oxidative stress, we hypothesized that cells expressing high levels of ALDH may be more chemoresistant due to their increased detoxifying capacity and that inhibitors of ALDHs may sensitize them to these drugs...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28881576/inhibition-of-pi3k-akt-mtor-signaling-in-pi3kr2-overexpressing-colon-cancer-stem-cells-reduces-tumor-growth-due-to-apoptosis
#13
Sugong Chen, Robert C Fisher, Steven Signs, L Alex Molina, Anitha K Shenoy, Maria-Cecilia Lopez, Henry V Baker, John M Koomen, Yi Chen, Haley Gittleman, Jill Barnholtz-Sloan, Annamarie Berg, Henry D Appelman, Emina H Huang
In sporadic colon cancer, colon cancer stem cells (CCSCs) initiate tumorigenesis and may contribute to late disease recurrences and metastases. We previously showed that aldehyde dehydrogenase (ALDH) activity (as indicated by the ALDEFLUOR(®) assay) is an effective marker for highly enriching CCSCs for further evaluation. Here, we used comparative transcriptome and proteome approaches to identify signaling pathways overrepresented in the CCSC population. We found overexpression of several components of the phosphoinositide 3-kinase (PI3K)/Akt/mechanistic target of rapamycin (mTOR) signaling pathway, including PI3KR2, a regulatory subunit of PI3K...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28881356/aldehyde-dehydrogenase-1b1-a-novel-immunohistological-marker-for-colorectal-cancer
#14
Akiko Matsumoto, John Arcaroli, Ying Chen, Maura Gasparetto, Veronique Neumeister, David C Thompson, Surendra Singh, Clayton Smith, Wells Messersmith, Vasilis Vasiliou
BACKGROUND: Aldehyde dehydrogenase (ALDH) 1A1 is an immunohistological biomarker of various solid tumours, but has not been successfully proved as a colorectal cancer (CRC) marker. We recently reported that ALDH1B1, which has functional roles in tumourigenesis, may be a better CRC marker than ALDH1A1. METHODS: Human CRC explants and cell lines were analysed to identify candidate CRC markers from eight ALDH isozymes including ALDH1A1 and ALDH1B1. A tissue microarray, including paired specimens of normal and tumour tissues, was subsequently analysed to determine if candidate ALDHs could distinguish CRC from normal tissue...
September 7, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28878571/ribonucleic-acid-interference-knockdown-of-il-6-enhances-the-efficacy-of-cisplatin-in-laryngeal-cancer-stem-cells-by-down-regulating-the-il-6-stat3-hif1-pathway
#15
Qiang Fu, Pengruofeng Liu, Xiumei Sun, Shanshan Huang, Fengchan Han, Lili Zhang, Yannan Xu, Tingyan Liu
BACKGROUND: Cisplatin has been used in the treatment of many cancers, including laryngeal cancer; however, its efficacy can be reduced due to the development of drug resistance. This study aimed to investigate whether interleukin-6 (IL-6) knockdown may enhance the efficacy of cisplatin in laryngeal cancer stem cells (CSC) and the potential involvement of the signal transducer and activator of transcription 3 (STAT3) and hypoxia-inducible factor 1 (HIF1) in this effect. METHODS: The ALDH+ and CD44+ CSC in Hep2 human laryngeal squamous cancer cells were identified by the fluorescence-activated cell sorting technique...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28875004/a-comparative-cytotoxic-evaluation-of-disulfiram-encapsulated-plga-nanoparticles-on-mcf-7-cells
#16
Hamidreza Fasehee, Ardeshir Ghavamzadeh, Kamran Alimoghaddam, Seyed-Hamidollah Ghaffari, Shahab Faghihi
Background: Disulfiram is oral aldehyde dehydrogenase (ALDH) inhibitor that has been used in the treatment of alcoholism. Recent studies show that this drug has anticancer properties; however, its rapid degradation has limited its clinical application. Encapsulation of disulfiram polymeric nanoparticles (NPs) may improve its anticancer activities and protect rapid degradation of the drug. Materials andMethods: A poly (lactide-co-Glycolide) (PLGA) was developed for encapsulation of disulfiram and its delivery into breast cancer cells...
April 1, 2017: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/28870918/the-diagnostic-significance-of-serum-alcohol-dehydrogenase-isoenzymes-and-aldehyde-dehydrogenase-activity-in-prostate-cancer-patients
#17
Karolina Orywal, Wojciech Jelski, Tadeusz Werel, Maciej Szmitkowski
BACKGROUND/AIM: The aim of this study was to investigate a potential role of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) as tumor markers for prostate cancer (PCa). MATERIALS AND METHODS: Serum samples were obtained from 52 patients with PCa, 34 patients with benign prostatic hyperplasia (BPH) and 60 healthy subjects. Class III and IV of ADH and total ADH activity were measured by the photometric method. For measurement of class I and II ADH and ALDH activity, the fluorometric method was employed...
September 2017: Anticancer Research
https://www.readbyqxmd.com/read/28867386/aldh7a1-is-a-protein-that-protects-atlantic-salmon-against-aeromonas-salmonicida-at-the-early-stages-of-infection
#18
Peng-Fei Liu, Yishuai Du, Lingjie Meng, Xian Li, Ying Liu
Aldehyde dehydrogenases (ALDHs) belong to a super-family of detoxifying proteins and perform a significant role in developing epithelial homeostasis, protecting cells from toxic aldehydes and drug resistance. However, the activity and function of these detoxifying proteins remain unknown, especially in fish. In our research, we aimed to study functions of aldehyde dehydrogenase 7A1 (ALDH7A1) in Atlantic salmon infected by Aeromonas salmonicida. Recombinant ALDH7A1 (rALDH7A1) was verified by SDS-PAGE and western blot...
September 1, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28864067/a-novel-chemoradiation-targeting-stem-and-nonstem-pancreatic-cancer-cells-by-repurposing-disulfiram
#19
Juan Cong, Yangyang Wang, Xiao Zhang, Nan Zhang, Ling Liu, Klara Soukup, Theodoros Michelakos, Theodore Hong, Albert DeLeo, Lei Cai, Francesco Sabbatino, Soldano Ferrone, Hang Lee, Vera Levina, Bryan Fuchs, Kenneth Tanabe, Keith Lillemoe, Cristina Ferrone, Xinhui Wang
Pancreatic ductal adenocarcinoma (PDAC) has a 5-year survival rate of 6% and is projected to be the second leading cause of cancer death by 2030, underscoring the urgency to develop new strategies to improve current therapeutic modalities for PDAC. Targeting pancreatic cancer stem cells (PCSCs), which are resistant to radiation and chemotherapy, is a promising strategy. A novel approach which can be readily clinically translated is to repurpose disulfiram (DSF), a drug for treating alcoholism, to target PCSCs...
August 30, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28844650/characterization-of-fadu-r-a-radioresistant-head-and-neck-cancer-cell-line-and-cancer-stem-cells
#20
Kwang-Jae Cho, Eun-Ji Park, Min-Sik Kim, Young-Hoon Joo
OBJECTIVES: The aim of this study was to evaluate the impact of CSC on insensitivity to radiotherapy in HNSCC. METHODS: A radioresistant cell line, FaDu-R, was established using fractionated ionizing radiation. Cells with high and low CD44/ALDH activity were isolated. RESULTS: FaDu-R cells demonstrated significantly increased cell viability after radiation exposure compared with parental cells. CD44(high)/ALDH(high) FaDu-R cells demonstrated significantly faster wound closure (p<0...
August 24, 2017: Auris, Nasus, Larynx
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