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https://www.readbyqxmd.com/read/27936437/clinical-trial-methodology-to-assess-the-efficacy-effectiveness-of-long-acting-antipsychotics-randomized-controlled-trials-vs-naturalistic-studies
#1
REVIEW
Andrea Fagiolini, Paola Rocca, Serafino De Giorgi, Edoardo Spina, Giovanni Amodeo, Mario Amore
Schizophrenia presents unique difficulties in clinical trial design associated with the condition's variable presentation and clinical course, and multiple features influencing affect, cognition, volition and perception. Randomized controlled trials (RCTs) are explanatory studies using a carefully selected patient population, predefined assessment intervals and, generally, symptom-focused endpoints. Naturalistic studies are pragmatic, with no active intervention, and outcomes that are generally those used in clinical practice (e...
November 28, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27936413/interactive-registration-between-supine-and-prone-scans-in-computed-tomography-colonography-using-band-height-images
#2
Youngchan Song, Hyunna Lee, Ho Chul Kang, Juneseuk Shin, Gil-Sun Hong, Seong Ho Park, Jeongjin Lee, Yeong-Gil Shin
In computed tomographic colonography (CTC), a patient is commonly scanned twice including supine and prone scans to improve the sensitivity of polyp detection. Typically, a radiologist must manually match the corresponding areas in the supine and prone CT scans, which is a difficult and time-consuming task, even for experienced scan readers. In this paper, we propose a method of supine-prone registration utilizing band-height images, which are directly constructed from the CT scans using a ray-casting algorithm containing neighboring shape information...
December 1, 2016: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/27936257/-institutions-without-history-an-investigation-into-the-archives-of-a-private-psychiatric-hospital-france-1930-1950
#3
Hervé Guillemain
Objectives Discovered by following the story of a Parisian patient, l'Hôpital psychiatrique de Saint-Rémy opened in 1937 in the east of France. It is a special institution that was created for profit and in an emergency context during the 1930s.Methods Due to the absence of administrative records, the history of this institution can be written only by using the archives of the Parisian administration and patient records. The story of this special institution allows several issues in the historiography of psychiatry: the funding of mental health, the patient transfers, the revival of the criticism against the psychiatric hospital...
2016: Santé Mentale Au Québec
https://www.readbyqxmd.com/read/27936253/-lack-of-collaboration-lack-of-staff-or-disappearance-of-the-data-the-difficult-access-to-the-psychiatric-archives
#4
Marie LeBel
This paper presents the way we try to track the history of mental health services offered to residents of official language minority communities throughout Northern and Eastern Ontario. The study also holds an interest in the post-deinstitutionalization paths of patients suffering from mental health conditions. Our research strand concerns Northern Ontario, its patient associations, its services, its specialists and its institutions and the access to hospitals archives.
2016: Santé Mentale Au Québec
https://www.readbyqxmd.com/read/27936042/influence-of-biodentine%C3%A2-a-dentine-substitute-on-collagen-type-i-synthesis-in-pulp-fibroblasts-in-vitro
#5
Frangis Nikfarjam, Kim Beyer, Anke König, Matthias Hofmann, Manuel Butting, Eva Valesky, Stefan Kippenberger, Roland Kaufmann, Detlef Heidemann, August Bernd, Nadja Nicole Zöller
Preserving a patient's own teeth-even in a difficult situation-is nowadays preferable to surgical intervention and therefore promotes development of suitable dental repair materials. Biodentine®, a mineral trioxide aggregate substitute, has been used to replace dentine in a bioactive and biocompatible manner in both the dental crown and the root. The aim of our study was to evaluate the influence of Biodentine® on pulp fibroblasts in vitro. For this study, one to five Biodentine® discs with a diameter of 5...
2016: PloS One
https://www.readbyqxmd.com/read/27935883/-roentgen-endovascular-treatment-of-common-carotid-artery-dissection-after-eversion-carotid-endarterectomy
#6
V N Tsygankov, A M Frantsevich, A A Sidorov, A I Goncharov, A E Zotikov, O L Talybly
The article deals with the use of self-expanding stents for endovascular treatment in patients presenting with dissection of the common carotid artery, exemplified by two clinical case reports. In both cases, dissection of the common carotid artery developed after eversion carotid endarterectomy. Intimal detachment was eliminated in both cases by implanting self-expanding stents. These cases demonstrated possibilities of roentgen endovascular methods of treatment making it possible to successfully replace a repeat, technically difficult surgical intervention for iatrogenic dissection of the common carotid artery...
2016: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/27935781/the-neurotoxicity-of-general-anesthetic-drugs-emphasis-on-the-extremes-of-age
#7
Chuck Biddle, Vincent Ford
A substantial body of research suggests that anesthetic exposure to patients who are very young or very old may impair cognitive, behavioral, and emotional development or recovery. In lower animal models of pre- and postnatal age, anesthetic exposure may impact inflammation, synaptogenesis, neuronal apoptosis, and glial cell development. To date, research in humans is inconclusive regarding the long-term cognitive and behavioral sequelae of general anesthesia in the young child. In older adults, postoperative cognitive dysfunction and cognitive delirium are identified as markers of anesthetic neurotoxicity...
January 2017: Annual Review of Nursing Research
https://www.readbyqxmd.com/read/27935771/preparing-anesthetists-to-manage-cannot-intubate-cannot-ventilate-situations
#8
Kenneth A Wofford
Cannot intubate/cannot ventilate (CICV) situations during anesthesia are rare, potentially catastrophic to the patient, and difficult to predict. Widely adopted practice guidelines advocate an algorithmic approach to CICV situations in which the anesthetist: (a) recognizes the CICV situation, (b) calls for help, (c) steadily progresses through a variety of methods to ventilate the patient and secure the airway, (d) restores ventilation via an infraglottic airway if the patient cannot be safely awakened prior to becoming moribund...
January 2017: Annual Review of Nursing Research
https://www.readbyqxmd.com/read/27935630/appreciable-uncertainty-regarding-benefits-and-risks-in-the-treatment-of-bacterial-vaginosis-to-prevent-preterm-birth
#9
Thor Haahr, Anne S Ersbøll, Mona A Karlsen, Jens Svare, Kirstine Sneider, Lene Hee, Louise K Weile, Agnes Ziobrowska-Bech, Claus Østergaard, Jørgen S Jensen, Rikke B Helmig, Niels Uldbjerg
As part of his speeches, the Roman senator Cato the Elder frequently uttered "Carthago delenda est" (Carthage must be destroyed). Similarly, Lamont and colleagues frequently utter that the "wrong patients with the wrong diagnosis were given wrong antibiotics at the wrong gestational age". We respect that Lamont and colleagues find it difficult to accept meta-analyses, which "cut a toe and a bit of a heel" to merge evidence from more publications, and we certainly cannot exclude the possibility that future research will change clinical practice...
December 9, 2016: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/27935361/acute-impairment-of-saccadic-eye-movements-is-associated-with-delayed-cerebral-ischemia-after-aneurysmal-subarachnoid-hemorrhage
#10
Matthew J Rowland, Payashi Garry, Jon Westbrook, Rufus Corkill, Chrystalina A Antoniades, Kyle T S Pattinson
OBJECTIVE Delayed cerebral ischemia (DCI) causing cerebral infarction remains a significant cause of morbidity and mortality following aneurysmal subarachnoid hemorrhage (aSAH). Early brain injury in the first 72 hours following rupture is likely to play a key role in the pathophysiology underlying DCI but remains difficult to quantify objectively. Current diagnostic modalities are based on the concept of vasoconstriction causing cerebral ischemia and infarction and are either invasive or have a steep learning curve and user variability...
December 9, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27935263/new-glycemic-targets-for-patients-with-diabetes-from-the-japan-diabetes-society
#11
Eiichi Araki, Masakazu Haneda, Masato Kasuga, Takeshi Nishikawa, Tatsuya Kondo, Kohjiro Ueki, Takashi Kadowaki
In the 'Evidence-based Practice Guideline for the Treatment for Diabetes in Japan 2013', a new concept of the glycemic control in patients with diabetes in Japan has been declared from the Japan Diabetes Society. The main objective value of HbA1c was set to <7% from the perspective of preventing microvascular complications. On the other hand, the objective in cases where objectives can be attained by appropriate dietary or exercise therapy, or during pharmacotherapy without the occurrence of side effects such as hypoglycemia was set to <6%, and the objective in cases where intensification of treatment was considered difficult due to side effects such as hypoglycemia or for other reasons was set to <8%...
December 9, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27935168/effectiveness-and-safety-of-sofosbuvir-based-regimens-plus-an-ns5a-inhibitor-for-patients-with-hcv-genotype-3-infection-and-cirrhosis-results-of-a-multicenter-real-life-cohort
#12
S Alonso, M Riveiro-Barciela, I Fernandez, D Rincón, Y Real, S Llerena, F Gea, A Olveira, C Fernandez-Carrillo, B Polo, J A Carrión, A Gómez, M J Devesa, C Baliellas, Á Castro, J Ampuero, R Granados, J M Pascasio, A Rubín, J Salmeron, E Badia, J M M Planas, S Lens, J Turnes, J L Montero, M Buti, R Esteban, C M Fernández-Rodríguez
Patients with HCV genotype 3 (GT3) infection and cirrhosis are currently the most difficult to cure. We report our experience with sofosbuvir+daclatasvir (SOF+DCV) or sofosbuvir/ledipasvir (SOF/LDV), with or without ribavirin (RBV) in clinical practice in this population. This was a multicenter observational study including cirrhotic patients infected by HCV GT3, treated with sofosbuvir plus an NS5A inhibitor (May 2014-October 2015). In total, 208 patients were included: 98 (47%) treatment-experienced, 42 (20%) decompensated and 55 (27%) MELD score >10...
December 9, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27934674/should-attendance-be-required-in-lecture-classrooms-in-dental-education-two-viewpoints-viewpoint-1-attendance-in-the-lecture-classroom-should-be-required-and-viewpoint-2-attendance-should-not-be-required-in-the-lecture-classroom
#13
Christopher W Cutler, Mary Parise, Ana Lucia Seminario, Maria Jose Cervantes Mendez, Wilhelm Piskorowski, Renato Silva
This Point/Counterpoint discusses the long-argued debate over whether lecture attendance in dental school at the predoctoral level should be required. Current educational practice relies heavily on the delivery of content in a traditional lecture style. Viewpoint 1 asserts that attendance should be required for many reasons, including the positive impact that direct contact of students with faculty members and with each other has on learning outcomes. In lectures, students can more easily focus on subject matter that is often difficult to understand...
December 2016: Journal of Dental Education
https://www.readbyqxmd.com/read/27933567/impact-of-endoscopic-ultrasound-guided-fine-needle-aspiration-in-prospective-liver-transplant-recipients-with-hepatocellular-carcinoma-and-lymphadenopathy
#14
Narendra S Choudhary, Rajesh Puri, Sanjiv Saigal, Prashant Bhangui, Neeraj Saraf, Vinit Shah, Mukesh Nasa, Haimanti Sarin, Mridula Guleria, Randhir Sud, Arvinder S Soin
BACKGROUND: Diagnosis of metastatic disease is important in patients with cirrhosis and hepatocellular carcinoma (HCC) to prevent futile liver transplantation. Some of these patients have metastatic lymphadenopathy; however, it is difficult to perform percutaneous fine-needle aspiration due to presence of collateral and anatomic location. Endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA) of lymph nodes offers several advantages like real-time vision, proximity to target, and avoidance of collaterals...
December 8, 2016: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/27933473/high-percentage-of-ibd-patients-with-indefinite-fecal-calprotectin-levels-additional-value-of-a-combination-score
#15
Alexander G L Bodelier, Daisy Jonkers, Tim van den Heuvel, Evelien de Boer, Wim Hameeteman, Ad A M Masclee, Marie J Pierik
BACKGROUND AND AIM: Monitoring mucosal inflammation in inflammatory bowel disease (IBD) is of major importance to prevent complications and improve long-term disease outcome. The correlation of clinical activity indices with endoscopic disease activity is, however, moderate. Fecal calprotectin (FC) is a better predictor of mucosal inflammation, but values between 100 and 250 µg/g are difficult to interpret in clinical practice. We aimed to evaluate the occurrence of indefinite FC levels in a real-life IBD cohort and study the additional value of a combination of biochemical markers and clinical activity indices...
December 8, 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27933386/endoscopic-submucosal-dissection-specimens-in-early-colorectal-cancer-lateral-margins-macroscopic-techniques-and-possible-pitfalls
#16
Alicia Dessain, Christophe Snauwaert, Pamela Baldin, Pierre Deprez, Louis Libbrecht, Hubert Piessevaux, Anne Jouret-Mourin
Endoscopic submucosal dissection (ESD) allows en-bloc resection of superficial gastrointestinal tumors, providing specimens on which lateral margin analysis can be performed reliably. Positive lateral margins have been linked to higher rates of recurrence/residual tumor. There are no guidelines for macroscopic processing of lateral margins. Currently, most institutions use parallel lateral sections, which are difficult to interpret. We use perpendicular lateral sections, hypothesizing that it decreases potential artifactually positive lateral margins...
December 8, 2016: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/27933351/-modern-modifications-of-uvulopalatopharyngoplasty
#17
T Verse, B A Stuck
Uvulopalatopharyngoplasty (UPPP) was first described in 1964 with regard to surgical treatment of snoring and in 1981 with regard to treatment of obstructive sleep apnea (OSA). The initial surgical techniques for OSA were very invasive, frequently leading to significant morbidity and complications. Wolfgang Pirsig et al. were the first in Germany to recognize that a radical surgical technique increased only the complications, not the efficacy of UPPP. The less invasive surgical technique developed based on these findings is still established in Germany...
December 8, 2016: HNO
https://www.readbyqxmd.com/read/27933249/an-enterogenous-cyst-with-atypical-pathological-findings-and-chemical-meningitis
#18
Lu Wang, Xiaona Chang, Chao Fu, Weidong Yu, Xiaoxuan Fang
INTRODUCTION: Intracranial enterogenous cysts are rare and mainly occur in the posterior fossa. These cysts are usually extra-axial, midline, anterior to the brainstem, or at the cerebellopontine angle. We report a case of an enterogenous cyst in which diagnosis was difficult because the lesion showed atypical pathologic findings. CASE PRESENTATION: A healthy 41-year-old man complained of paroxysmal occipital headaches lasting over a week, with increased severity for 3 days accompanied by slight dizziness and mild nausea...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27933242/transtuzumab-induced-organizing-pneumonia-a-case-report
#19
Ajay Gupta, Louise Teo, Philip Masel, David Godbolt, Geoffrey Beadle
BACKGROUND: Patients with metastatic breast cancer often have pulmonary symptoms with varying aetiologies. Transtuzumab is an extremely important drug used in the treatment of Her 2 neu over-expressing breast cancers. In this report we describe a case of organizing pneumonia associated with use of transtuzumab in metastatic breast cancer. Only three such cases have previously been reported. CASE DESCRIPTION: A 43 year old lady with Her 2 neu 3+, estrogen and progesterone receptor positive, metastatic breast cancer was started on weekly transtuzumab and albumen bound paclitaxel...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27933148/role-of-peer-support-workers-in-improving-patient-experience-in-tower-hamlets-specialist-addiction-unit
#20
Wiktor Kulik, Amar Shah
The aim of the project was to improve patient experience for people in Tower Hamlets Specialist Addictions Unit in order to increase satisfaction by 25% in 12 months starting in August 2014. The team used the model for improvement as part of ELFT's quality improvement programme to support iterative cycles of testing and learning. This involved support from the Trust's quality improvement team. The theory of change was visualised through a driver diagram. A number of outcomes were measured and plotted over time - patient satisfaction, staff satisfaction, and attendance to peer support groups...
2016: BMJ Quality Improvement Reports
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