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Adam M Leventhal, Matthew D Stone, Nafeesa Andrabi, Jessica Barrington-Trimis, David R Strong, Steve Sussman, Janet Audrain-McGovern
No abstract text is available yet for this article.
November 8, 2016: JAMA: the Journal of the American Medical Association
Rob McConnell, Jessica L Barrington-Trimis, Kejia Wang, Robert Urman, Hanna Hong, Jennifer Unger, Jonathan Samet, Adam Leventhal, Kiros Berhane
BACKGROUND: Rates of adolescent electronic (e-) cigarette use are increasing, but there has been little study of the chronic effects of use. Components of e-cigarette aerosol have known pulmonary toxicity. METHODS: Associations of self-reported use of e-cigarettes with chronic bronchitic symptoms (chronic cough, phlegm or bronchitis) and of wheeze in the previous 12 months were examined in 2086 Southern California Children's Health Study participants completing questionnaires in 11th and 12th grade in 2014...
November 2, 2016: American Journal of Respiratory and Critical Care Medicine
Jessica L Barrington-Trimis, Myles Cockburn, Catherine Metayer, W James Gauderman, Joseph Wiemels, Roberta McKean-Cowdin
Incidence rates of childhood leukemia in the United States have steadily increased over the last several decades, but only recently have disparities in the increase in incidence been recognized. In the current analysis, Surveillance, Epidemiology and End Results (SEER) data were used to evaluate recent trends in the incidence of childhood leukemia diagnosed at age 0-19 years from 1992 to 2013, overall and by age, race/ethnicity, gender and histologic subtype. Hispanic White children were more likely than non-Hispanic White, non-Hispanic Black or non-Hispanic Asian children to be diagnosed with acute lymphocytic leukemia (ALL) from 2009 to 2013...
March 1, 2017: International Journal of Cancer. Journal International du Cancer
Nicholas I Goldenson, Matthew G Kirkpatrick, Jessica L Barrington-Trimis, Raina D Pang, Julia F McBeth, Mary Ann Pentz, Jonathan M Samet, Adam M Leventhal
INTRODUCTION: Product characteristics that impact e-cigarette appeal by altering the sensory experience of vaping need to be identified to formulate evidence-based regulatory policies. While products that contain sweet flavorings and produce a "throat hit" (i.e., desirable airway irritation putatively caused by nicotine) are anecdotally cited as desirable reasons for vaping among young adults, experimental evidence of their impact on user appeal is lacking. This experiment applied a novel laboratory protocol to assess whether: (1) sweet flavorings and nicotine affect e-cigarette appeal; (2) sweet flavorings increase perceived sweetness; (3) nicotine increases throat hit; and (4) perceived sweetness and throat hit are associated with appeal...
November 1, 2016: Drug and Alcohol Dependence
Christina Jeon, Keum Ji Jung, Heejin Kimm, Sungkyu Lee, Jessica L Barrington-Trimis, Rob McConnell, Jonathan M Samet, Sun Ha Jee
OBJECTIVE: To examine risk factors associated with use of e-cigarettes only, conventional cigarettes only, and dual use in Korean adolescents and young adults. METHODS: In a cross-sectional study, anonymous questionnaires were completed between April-May, 2015 among 1) 2744 middle and high school students, aged 13-18, from Seoul, Incheon, Gyeonggi, and Cheongju, Korea and 2) 2167 university students, aged 19-29, from fourteen universities in Korea. RESULTS: The results show that 12...
September 5, 2016: Drug and Alcohol Dependence
Jessica L Barrington-Trimis, Robert Urman, Adam M Leventhal, W James Gauderman, Tess Boley Cruz, Tamika D Gilreath, Steve Howland, Jennifer B Unger, Kiros Berhane, Jonathan M Samet, Rob McConnell
BACKGROUND: Adolescent e-cigarette use has increased rapidly in recent years, but it is unclear whether e-cigarettes are merely substituting for cigarettes or whether e-cigarettes are being used by those who would not otherwise have smoked. To understand the role of e-cigarettes in overall tobacco product use, we examine prevalence rates from Southern California adolescents over 2 decades. METHODS: The Children's Health Study is a longitudinal study of cohorts reaching 12th grade in 1995, 1998, 2001, 2004, and 2014...
August 2016: Pediatrics
Jessica L Barrington-Trimis, Robert Urman, Kiros Berhane, Jennifer B Unger, Tess Boley Cruz, Mary Ann Pentz, Jonathan M Samet, Adam M Leventhal, Rob McConnell
BACKGROUND: There has been little research examining whether e-cigarette use increases the risk of cigarette initiation among adolescents in the transition to adulthood when the sale of cigarettes becomes legal. METHODS: The Children's Health Study is a prospectively followed cohort in Southern California. Data on e-cigarette use were collected in 11th and 12th grade (mean age = 17.4); follow-up data on tobacco product use were collected an average of 16 months later from never-smoking e-cigarette users at initial evaluation (n = 146) and from a sample of never-smoking, never e-cigarette users (n = 152) frequency matched to e-cigarette users on gender, ethnicity, and grade...
July 2016: Pediatrics
Jessica L Barrington-Trimis, Kiros Berhane, Jennifer B Unger, Tess Boley Cruz, Robert Urman, Chih Ping Chou, Steve Howland, Kejia Wang, Mary Ann Pentz, Tamika D Gilreath, Jimi Huh, Adam M Leventhal, Jonathan M Samet, Rob McConnell
PURPOSE: One concern regarding the recent increase in adolescent e-cigarette use is the possibility that electronic (e-) cigarettes may be used by those who might not otherwise have used cigarettes, and that dual use, or transition to cigarette use alone, may follow. METHODS: Questionnaire data were obtained in 2014 from 11th/12th grade students attending schools in 12 communities included in the Southern California Children's Health Study. We evaluated the cross-sectional association between e-cigarette use, the social environment (family and friends' use and approval of e-cigarettes and cigarettes), and susceptibility to future cigarette use among never cigarette smokers (N = 1,694), using previously validated measures based on reported absence of a definitive commitment not to smoke...
July 2016: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
Adam M Leventhal, David R Strong, Steve Sussman, Matthew G Kirkpatrick, Jennifer B Unger, Jessica L Barrington-Trimis, Janet Audrain-McGovern
The popularity of electronic (e-) cigarettes has greatly increased recently, particularly in adolescents. However, the extent of psychiatric comorbidity with adolescent e-cigarette use and dual use of conventional (combustible) and e-cigarettes is unknown. This study characterized psychiatric comorbidity in adolescent conventional and e-cigarette use. Ninth grade students attending high schools in Los Angeles, CA (M age = 14) completed self-report measures of conventional/e-cigarette use, emotional disorders, substance use/problems, and transdiagnostic psychiatric phenotypes consistent with the NIMH-Research Domain Criteria Initiative...
February 2016: Journal of Psychiatric Research
Tamika D Gilreath, Adam Leventhal, Jessica L Barrington-Trimis, Jennifer B Unger, Tess Boley Cruz, Kiros Berhane, Jimi Huh, Robert Urman, Kejia Wang, Steve Howland, Mary Ann Pentz, Chih Ping Chou, Rob McConnell
PURPOSE: There is a growing public health concern related to the rapid increase in the use of multiple tobacco products among adolescents. This study examined patterns of adolescent use of cigarettes, e-cigarettes, cigars/cigarillo, hookah/waterpipe, and smokeless/dip/chewing tobacco in a population of southern California adolescents. METHODS: Data from 2,097 11th- and 12th-grade participants in the Southern California Children's Health Study were collected via self-report in 2014...
February 2016: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
Jessica L Barrington-Trimis, Kiros Berhane, Jennifer B Unger, Tess Boley Cruz, Jimi Huh, Adam M Leventhal, Robert Urman, Kejia Wang, Steve Howland, Tamika D Gilreath, Chih-Ping Chou, Mary Ann Pentz, Rob McConnell
BACKGROUND: Use of electronic cigarettes (e-cigarettes) among adolescents has increased since their introduction into the US market in 2007. Little is known about the role of e-cigarette psychosocial factors on risk of e-cigarette or cigarette use in adolescence. METHODS: Information on e-cigarette and cigarette psychosocial factors (use and attitudes about use in the home and among friends) was collected from 11th- and 12th-grade participants in the Southern California Children's Health Study during the spring of 2014...
August 2015: Pediatrics
Dimitra Koukou, Panagiota Chatzichristou, Georgios Trimis, Tania Siahanidou, Anna-Venetia Skiathitou, Emmanouil I Koutouzis, George A Syrogiannopoulos, Athanasia Lourida, Athanasios G Michos, Vassiliki P Syriopoulou
INTRODUCTION: Rotavirus (RV) infection in neonatal age can be mild or even asymptomatic. Several studies have reported that RV is responsible for 31%-87% of pediatric nosocomial diarrhea and causes gastroenteritis outbreaks in pediatric and neonatal units. OBJECTIVES: Study clinical characteristics, genotypes and risk factors of RV infection in neonatal age. METHODS: A prospective study was conducted from April 2009 till April 2013 in the neonatal special care unit of the largest tertiary pediatric hospital of Greece...
2015: PloS One
Jessica L Barrington-Trimis, Jonathan M Samet, Rob McConnell
No abstract text is available yet for this article.
December 17, 2014: JAMA: the Journal of the American Medical Association
Jessica L Barrington-Trimis, Susan Searles Nielsen, Susan Preston-Martin, W James Gauderman, Elizabeth A Holly, Federico M Farin, Beth A Mueller, Roberta McKean-Cowdin
BACKGROUND: A recent meta-analysis suggested an association between exposure to paternal smoking during pregnancy and childhood brain tumor risk, but no studies have evaluated whether this association differs by polymorphisms in genes that metabolize tobacco-smoke chemicals. METHODS: We assessed 9 functional polymorphisms in 6 genes that affect the metabolism of polycyclic aromatic hydrocarbons (PAH) to evaluate potential interactions with parental smoking during pregnancy in a population-based case-control study of childhood brain tumors...
2013: PloS One
Roberta McKean-Cowdin, Pedram Razavi, Jessica Barrington-Trimis, Rachel Tobias Baldwin, Shahab Asgharzadeh, Myles Cockburn, Tarik Tihan, Susan Preston-Martin
In the mid-1980s, there was a rise in incidence rates of childhood brain tumors (CBT) in the United States that appeared to stabilize at a higher rate in the early 1990 s. An updated analysis of the pattern of CBT over the past 2 decades, with commentary on whether the elevated incidence rate has continued, is past due. We used Surveillance, Epidemiology and End Results (SEER) data to examine trends in incidence of CBT from 1973 through 2009. We examined age-adjusted incidence rates (AAIRs) and secular trends for all malignant brain tumors combined (SEER classification) by histologic tumor type and anatomic site...
November 2013: Journal of Neuro-oncology
Elena Farmaki, Ioulia Chatzistamou, Panagiotis Bourlis, Eleni Santoukou, George Trimis, Athanasios G Papavassiliou, Hippokratis Kiaris
The tumor microenvironment is considered pro-oncogenic for reasons that, among others, involve the stimulation of cancer cell growth. However, little is known regarding how the tumor microenvironment affects the proliferation of stromal cells that coexist with cancer cells in the tumors. In the present study, we show that cancer cells trigger a paracrine response in normal fibroblasts that is not consistently mitogenic but may also become antimitogenic, inhibiting fibroblasts' proliferation in vitro. In vivo experiments on xenografts of MDA-MB-231 breast and A549 lung cancer cells in SCID mice or primary Notch-induced breast cancers that develop in transgenic mice showed that stromal cells frequently undergo senescence, confirming the presence of stress-inducing conditions within the tumor's microenvironment...
September 2012: Genes & Cancer
Vasiliki Karathanasi, Konstantinos I Tosios, Nikolaos G Nikitakis, Evangelia Piperi, Ioannis Koutlas, George Trimis, Alexandra Sklavounou
OBJECTIVES: The TGF-β/Smad signaling pathway regulates diverse cellular functions, including tooth development, and is involved in numerous pathological processes such as tumorigenesis. The aim of this study was to investigate the immunoexpression of the TGF-β/Smad signaling pathway members in ameloblastoma (AM), calcifying cystic odontogenic tumor (CCOT), and adenomatoid odontogenic tumor (AOT). MATERIALS AND METHODS: This retrospective cross-sectional study included 65 tissue specimens: 34 AMs, 13 CCOTs, and 18 AOTs...
May 2013: Journal of Oral Pathology & Medicine
Georgios Trimis, Ioanna Koutsoumbari, Christine Kottaridi, Nikoletta Palaiologou, Efstathia Assimakopoulou, Aris Spathis, Evaggelia Lebessi, Andreas Konstantopoulos, Dimitris Kafetzis, Petros Karakitsos, Vassiliki Papaevangelou
To investigate possible impact of limited vaccine uptake by the private sector since 2007, a prospective observational study included all children <5 years hospitalized for acute gastroenteritis (AGE) in a Tertiary Care Hospital between 09/2006 and 08/2010. Rotavirus (RV) antigen was detected in stools by a rapid immunochromatographic test and genotype analysis was performed on positive samples by RT-PCR. Compared to 2006-2008, the likelihood of rotavirus infection was significantly reduced among children hospitalized for AGE in 2008-2010 (OR 0...
October 6, 2011: Vaccine
Ioulia Chatzistamou, Nikolina Dioufa, George Trimis, Alexandra Sklavounou, Christos Kittas, Hippokratis Kiaris, Athanasios G Papavassiliou
BACKGROUND: Concerted alterations between stromal fibroblasts and neoplastic cells underline the carcinogenic process. Activation of alpha-smooth muscle actin (SMA) expression, a cytoskeleton protein normally expressed only in myoepithelial cells, is considered a landmark for the activation of stromal fibroblasts with little however being known regarding the mechanism governing the expression of SMA in the stroma. METHODS: We have evaluated by immunohistochemistry the expression of SMA in the stroma of oral malignant and pre-malignant lesions, in association with the expression of p53 and p21 tumor suppressors that were shown previously to be deregulated and/or mutated in stromal fibroblasts of various cancers...
October 2011: Cellular Oncology (Dordrecht)
Vassiliki Syriopoulou, Dimitrios Kafetzis, Maria Theodoridou, George A Syrogiannopoulos, Stefanos Mantagos, Georgios Trimis, Maria Mavrikou, Andreas Konstantopoulos
AIM: To evaluate the potential benefits of introducing universal rotavirus (RV) vaccination in Greece. METHODS: A decision analytic model was developed to compare the burden and cost of rotavirus gastroenteritis (RVGE) with and without a universal RV vaccination (88% vaccination coverage) for a cohort of children followed from birth until the age of five. RESULTS: Universal RV vaccination would substantially decrease the RVGE burden on the National Health System by reducing RVGE-related hospitalizations/emergency visits and medical consultations by 83% and 75%, respectively...
May 2011: Acta Paediatrica
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