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https://www.readbyqxmd.com/read/28103612/a-phase-iii-randomised-controlled-trial-of-erlotinib-vs-gefitinib-in-advanced-non-small-cell-lung-cancer-with-egfr-mutations
#1
J J Yang, Q Zhou, H H Yan, X C Zhang, H J Chen, H Y Tu, Z Wang, C R Xu, J Su, B C Wang, B Y Jiang, X Y Bai, W Z Zhong, X N Yang, Y L Wu
BACKGROUND: A phase III trial was conducted to compare the safety and efficacy of erlotinib with that of gefitinib in advanced non-small cell lung cancer harbouring epidermal growth factor receptor mutations in exon 19 or 21. METHODS: Eligible patients were randomised to receive erlotinib (150 mg per day) or gefitinib (250 mg per day) orally until disease progression or unacceptable toxicity. We aimed to determine whether erlotinib is superior to gefitinib in efficacy...
January 19, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28103562/a-decision-support-system-for-tele-monitoring-copd-related-worrisome-events
#2
Mario Merone, Claudio Pedone, Giuseppe Capasso, Raffaele Antonelli Incalzi, Paolo Soda
Chronic Obstructive Pulmonary Disease (COPD) is a preventable, treatable and slowly progressive disease, whose course is aggravated by a periodic worsening of symptoms and lung function lasting for several days. The development of home telemonitoring systems has made possible to collect symptoms and physiological data in electronic records, boosting the development of decision support systems (DSSs). Current DSSs work with physiological measurements collected by means of several measuring and communication devices as well as with symptoms gathered by questionnaires submitted to COPD subjects...
January 17, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28103123/disease-burden-of-patients-with-asthma-copd-overlap-in-a-us-claims-database-impact-of-icd-9-coding-based-definitions
#3
Keele E Wurst, Samantha St Laurent, David Hinds, Kourtney J Davis
The inclusion of an asthma/chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) population in the 2015 Global Initiative for Chronic Obstructive Lung Disease strategic documents has raised questions about the profile of these patients in clinical practice, as they are mostly excluded from asthma and COPD clinical trials. We estimated the disease burden, co-morbidities, and respiratory treatments of patients with asthma/COPD overlap, utilizing the Truven MarketScan commercial and Medicare databases...
January 19, 2017: COPD
https://www.readbyqxmd.com/read/28102972/evaluating-the-clinical-copd-questionnaire-a-systematic-review
#4
REVIEW
Zijing Zhou, Aiyuan Zhou, Yiyang Zhao, Ping Chen
The Clinical COPD Questionnaire (CCQ) is recommended by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) to evaluate health status in patients with COPD. The objective of this work was to systemically assess the reliability, validity, responsiveness and minimum clinically important difference (MCID) of the CCQ. A structured search was conducted in three databases to identify articles that evaluated the psychometric properties of the CCQ in individuals with COPD. Two investigators screened the title, abstract and full text of the articles to determine study eligibility and performed the data extraction...
February 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28102970/microbiomes-in-respiratory-health-and-disease-an-asia-pacific-perspective
#5
REVIEW
Sanjay H Chotirmall, Shaan L Gellatly, Kurtis F Budden, Micheál Mac Aogain, Shakti D Shukla, David L A Wood, Philip Hugenholtz, Kevin Pethe, Philip M Hansbro
There is currently enormous interest in studying the role of the microbiome in health and disease. Microbiome's role is increasingly being applied to respiratory diseases, in particular COPD, asthma, cystic fibrosis and bronchiectasis. The changes in respiratory microbiomes that occur in these diseases and how they are modified by environmental challenges such as cigarette smoke, air pollution and infection are being elucidated. There is also emerging evidence that gut microbiomes play a role in lung diseases through the modulation of systemic immune responses and can be modified by diet and antibiotic treatment...
February 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28102969/acute-exacerbations-of-interstitial-lung-disease-don-t-just-do-something-stand-there
#6
EDITORIAL
Robert J Lentz, Fabien Maldonado
No abstract text is available yet for this article.
February 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28102852/anthropometric-trends-from-1997-to-2012-in-infants-born-at-%C3%A2-28-weeks-gestation-or-less
#7
N Wells, T A Stokes, K Ottolini, C H Olsen, A R Spitzer, C E Hunt
OBJECTIVE: Postnatal growth failure is common after preterm birth, in particular for infants born at ⩽28 weeks' gestation, but it is unknown if growth-to-term equivalent age has improved over the years as neonatal intensive care in general, and infant nutrition in particular, have improved. The objective of the study was to evaluate anthropometric trends at NICU discharge for infants born at ⩽28 weeks' gestation using a large national database. STUDY DESIGN: Analysis of growth in weight, length, head circumference and body mass index (kg m(2)) in 23 005 infants born in 1997 to 2012 who survived to neonatal intensive care unit discharge at ⩽41 weeks' postmenstrual age...
January 19, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28102546/ataluren-and-similar-compounds-specific-therapies-for-premature-termination-codon-class-i-mutations-for-cystic-fibrosis
#8
REVIEW
Aisha A Aslam, Colin Higgins, Ian P Sinha, Kevin W Southern
BACKGROUND: Cystic fibrosis is a common life-shortening genetic disorder in the Caucasian population (less common in other ethnic groups) caused by the mutation of a single gene that codes for the production of the cystic fibrosis transmembrane conductance regulator protein. This protein coordinates the transport of salt (and bicarbonate) across cell surfaces and the mutation most notably affects the airways. In the lungs of people with cystic fibrosis, defective protein results in a dehydrated surface liquid and compromised mucociliary clearance...
January 19, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28102063/sputum-inflammatory-mediators-are-increased-in-aspergillus-fumigatus-culture-positive-asthmatics
#9
Michael A Ghebre, Dhananjay Desai, Amisha Singapuri, Joanne Woods, Laura Rapley, Suzanne Cohen, Athula Herath, Andrew J Wardlaw, Catherine H Pashley, Richard May, Chris E Brightling
Aspergillus fumigatus sensitization and culture in asthma are associated with disease severity and lung function impairment, but their relationship with airway inflammation is poorly understood. We investigated the profile of 24 sputum inflammatory mediators in A. fumigatus culture-positive or-negative moderate-to-severe asthmatics. Fifty-two subjects were recruited from a single center. A. fumigatus was cultured from 19 asthmatics. Asthma control, symptom score, lung function, and sputum cell count were not significantly different between the asthmatics with and without a positive A...
March 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28101945/epidermal-growth-factor-receptor-egfr-mapk-nuclear-factor-nf-%C3%AE%C2%BAb-il8-a-possible-mechanism-of-particulate-matter-pm-2-5-induced-lung-toxicity
#10
Seung-Chan Jeong, Yoon Cho, Mi-Kyung Song, Eunil Lee, Jae-Chun Ryu
Airway inflammation plays a central role in the pathophysiology of diverse pulmonary diseases. In this study, we investigated whether exposure to particulate matter (PM) 2.5, a PM with an aerodynamic diameter of less than 2.5 µm, enhances inflammation-related toxicity in the human respiratory system through activation of the epidermal growth factor receptor (EGFR) signaling pathway. Through cytokine antibody array analysis of two extracts of PM2.5 [water (W-PM2.5 ) and organic (O-PM2.5 ) soluble extracts] exposed to A549 (human alveolar epithelial cell), we identified eight cytokines changed their expression with W-PM2...
January 19, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28101850/assessment-of-regional-pulmonary-blood-flow-using-68-ga-dota-pet
#11
Carlos Velasco, Jesus Mateo, Arnoldo Santos, Adriana Mota-Cobian, Fernando Herranz, Juan Pellico, Ruben A Mota, Samuel España, Jesus Ruiz-Cabello
BACKGROUND: In vivo determination of regional pulmonary blood flow (PBF) is a valuable tool for the evaluation of many lung diseases. In this study, the use of (68)Ga-DOTA PET for the in vivo quantitative determination of regional PBF is proposed. This methodology was implemented and tested in healthy pigs and validated using fluorescent microspheres. The study was performed on young large white pigs (n = 4). To assess the reproducibility and consistency of the method, three PET scans were obtained for each animal...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28101818/autophagy-is-a-regulator-of-trail-induced-apoptosis-in-nsclc-a549-cells
#12
Yuqing Chen, Xin Zhou, Jianou Qiao, Aihua Bao
Autophagy, a catabolic process by which cytoplasmic components are degraded in lysosomes, plays an important role in the maintenance of cellular homeostasis. Dysregulation of autophagy is associated with several diseases. However, few studies have addressed the role of autophagy in the lung, and its role in lung diseases remains unclear. In the present study, we examined the effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) on autophagy in A549 cells and explored the underlying mechanisms...
January 18, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28101234/dysregulation-of-malat1-and-mir-619-5p-as-a-prognostic-indicator-in-advanced-colorectal-carcinoma
#13
Gu Qiu, Xiu-Bing Zhang, Shu-Qing Zhang, Pei-Long Liu, Wei Wu, Jin-Ye Zhang, Shi-Rong Dai
The present study aimed to detect the expression of metastasis associated lung adenocarcinoma transcript 1 (MALAT1) and microRNA (miR)-619-5p in colorectal carcinoma (CRC), and to evaluate the significance of MALAT1 and miR-619-5p expression in the clinical diagnosis and prognosis of CRC. Quantitative polymerase chain reaction was used to detect MALAT1 and miR-619-5p expression in 120 colorectal carcinoma and 120 adjacent normal tissue samples. The expression levels of MALAT1 and miR-619-5p were significantly different between colorectal carcinoma and adjacent normal tissues (P<0...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28101226/evaluation-of-plasma-microrna-levels-to-predict-insensitivity-of-patients-with-advanced-lung-adenocarcinomas-to-pemetrexed-and-platinum
#14
Jinghua Zhu, Yuhua Qi, Jianzhong Wu, Meiqi Shi, Jifeng Feng, Longbang Chen
Pemetrexed combined with platinum is a first-line therapy used to treat patients with advanced non-small cell lung cancer (NSCLC) that exhibit negative or unknown epidermal growth factor receptor (EGFR) mutational status or anaplastic lymphoma kinase (ALK) rearrangements. Lung adenocarcinoma (LAC) is the primary type of NSCLC. In order to prevent overtreatment, it is necessary to identify patients with LAC who may not benefit from certain chemotherapies. Patients recruited in the present study (n=129) were diagnosed with advanced LAC and received first-line pemetrexed and platinum-based chemotherapy...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28101219/n-terminal-truncated-carboxypeptidase-e-expression-is-associated-with-poor-prognosis-of-lung-adenocarcinoma
#15
Jing Sun, Dawei Meng, Li Li, Xin Tian, Yunji Jia, Hongyue Wang, Huihui Yu, Tiemin Sun, Aibing Qu, Hui Shen, Jimin Bao, Guirong Zhang
Lung cancer is a malignant tumor with high morbidity and mortality rates. To date, no suitable molecular diagnostic tool to predict disease recurrence and metastasis has been identified. The current study aimed to evaluate the potential of N-terminal truncated carboxypeptidase E (CPEΔN) to predict the recurrence and metastasis of lung adenocarcinoma. Western blotting revealed the co-expression of CPE and CPEΔN in the surgically collected pathological and pericarcinoma tissues tissues of 62.1% (59/95) lung adenocarcinoma patients...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28101218/bevacizumab-pemetrexed-and-carboplatin-in-first-line-treatment-of-non-small-cell-lung-cancer-patients-focus-on-patients-with-brain-metastases
#16
Dimitra Stefanou, Sofia Stamatopoulou, Antigoni Sakellaropoulou, Gavriil Akakios, Marina Gkiaouraki, Despina Gkeka, Maria Prevezanou, Alexandros Ardavanis
Data concerning bevacizumab plus pemetrexed plus carboplatin as first-line treatment for patients with non-squamous non-small cell lung cancer (NSCLC) with or without brain metastases (BM) are lacking. The present study analyzed the efficacy and safety of this combination as induction therapy, followed by maintenance therapy with bevacizumab plus pemetrexed in non-squamous NSCLC patients with or without BM. Treatment-naïve patients with advanced non-squamous NSCLC and an Eastern Cooperative Oncology Group performance status score of 0-2 were eligible...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28101187/severe-pneumonia-due-to-infection-with-candida-krusei-in-a-case-of-suspected-middle-east-respiratory-syndrome-a-case-report-and-literature-review
#17
Mingming Tan, Junwei Wang, Peiyang Hu, Bin Wang, Wanghua Xu, Jiao Chen
Candida krusei (C. krusei) pneumonia is a rare infection that is frequently associated with a poor outcome. The present study reports an unusual case of C. krusei pneumonia that was initially suspected to be a Middle East respiratory syndrome (MERS) case. A 64-year-old Saudi Arabian male patient was admitted to our hospital with complaints of cough and dyspnea that persisted for 6 days. The patient presented fever (oral temperature, 38.5°C) and slight tachypnea (25 respirations/min). A chest computerized tomography demonstrated unclear lung fields, diffuse pathological changes in the two lungs and multiple lymphadenectasis in the retrocaval and para-aortic arch area...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28101024/bazex-syndrome-in-lung-squamous-cell-carcinoma-high-expression-of-epidermal-growth-factor-receptor-in-lesional-keratinocytes-with-th2-immune-shift
#18
Maki Amano, Takaaki Hanafusa, Sakiko Chikazawa, Makiko Ueno, Takeshi Namiki, Ken Igawa, Keiko Miura, Hiroo Yokozeki
An 82-year-old Japanese man was referred for detailed examination of hyperkeratotic erythematous plaques on his palms and soles for 6 months. Two weeks before his first visit, he had undergone lung lobectomy for right lung squamous cell carcinoma (SCC). Laboratory findings showed elevations of eosinophil counts, serum IgE, thymus and activation-regulated chemokine, SCC antigen, and soluble interleukin-2 receptor levels. Histological results of a skin biopsy involving the left palm showed psoriasiform dermatitis...
September 2016: Case Reports in Dermatology
https://www.readbyqxmd.com/read/28100713/ahrr-cg05575921-hypomethylation-marks-smoking-behaviour-morbidity-and-mortality
#19
Stig E Bojesen, Nicholas Timpson, Caroline Relton, George Davey Smith, Børge G Nordestgaard
RATIONALE AND OBJECTIVES: Self-reported smoking underestimates disease risk. Smoking affects DNA methylation, in particular the cg05575921 site in the aryl hydrocarbon receptor repressor (AHRR) gene. We tested the hypothesis that AHRR cg05575921 hypomethylation is associated with risk of smoking-related morbidity and mortality. METHODS: From the Copenhagen City Heart Study representing the Danish general population, we studied 9234 individuals. Using bisulphite treated leucocyte DNA, AHRR (cg05575921) methylation was measured...
January 18, 2017: Thorax
https://www.readbyqxmd.com/read/28100704/frequency-of-abnormal-pulmonary-computed-tomography-findings-in-asylum-seeking-refugees-in-turkey
#20
Levent Soydan, Ali Aslan Demir, Atadan Tunaci
BACKGROUND: Lungs are particularly vulnerable to both acute infections, including TB, and chronic diseases such as chronic obstructive pulmonary disease, as well as to malignancies, all of which require particular attention during war times in which health conditions are far from optimal. METHODS: This retrospective cross-sectional study included 1149 refugees that underwent thoracic computed tomography (CT) for respiratory symptoms between March 2013 and February 2015 in Turkey...
January 18, 2017: International Health
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