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https://www.readbyqxmd.com/read/29917332/comparing-first-line-treatment-patterns-and-clinical-outcomes-of-patients-with-pan-negative-advanced-non-squamous-non-small-cell-lung-cancer
#1
Haiyan Xu, Fei Xu, Wenjie Zhu, Jianming Ying, Yan Wang
BACKGROUND: Platinum-based chemotherapy is the standard first-line treatment for patients with advanced pan-negative non-squamous (non-Sq) non-small cell lung cancer (NSCLC). However, it is unknown which chemotherapy regimen confers the greatest benefit in such patients. This study explored which chemotherapy regimens were advantageous in non-Sq NSCLC patients. METHODS: A retrospective study was conducted on 114 patients with advanced non-Sq NSCLC using platinum-based chemotherapy in a first-line setting between January 2013 and December 2015...
June 19, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29917320/efficacy-of-repeated-surgery-is-superior-to-that-of-non-surgery-for-recurrent-second-primary-lung-cancer-after-initial-operation-for-primary-lung-cancer
#2
Haitao Zhou, Xiaozheng Kang, Liang Dai, Wanpu Yan, Yongbo Yang, Yao Lin, Ke-Neng Chen
BACKGROUND: The current study aimed to determine the oncological efficacy and surgical safety of multiple pulmonary resections (MPRs) after prior curative surgery for local regional recurrent or second primary lung cancers. METHODS: All cases of lung cancer included in our prospective database between January 2000 and July 2015 were retrospectively reviewed. The oncological efficacy endpoints for synchronous and metachronous MPR were five-year overall survival (OS), disease-free survival (DFS), and progression-free survival (PFS) rates after the second surgery...
June 19, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29917296/-experiences-of-the-burden-of-treatment-patient-reports-of-facilitated-subcutaneous-immunoglobulin-treatment-in-adults-with-immunodeficiency
#3
Christina Petersson, Ramona Fust, Carina Hagstedt, Per Vågström, Åsa Nilsdotter-Augustinsson
AIMS AND OBJECTIVES: To evaluate patient-reported experiences of facilitated subcutaneous immunoglobulin treatment in adults with primary or secondary immunodeficiency. BACKGROUND: Decreased levels of circulating antibodies (humoral immunodeficiency) are often associated with higher infection rates which cause problems in daily living, for example symptoms of severe and recurrent bacterial infections that may cause chronic lung diseases. For some diagnoses, treatment with immunoglobulin becomes critical and life-long...
June 19, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29917256/exhaled-breath-condensate-hydrogen-peroxide-ph-and-leukotriene-b-4-are-associated-with-lower-airway-inflammation-and-airway-cytology-in-the-horse
#4
S du Preez, S L Raidal, G S Doran, M Prescott, K J Hughes
BACKGROUND: Exhaled breath condensate (EBC) analysis is a non-invasive method to assess the lower respiratory tract. In humans, EBC hydrogen peroxide (H2 O2 ), pH and leukotriene B4 (LTB4 ) are useful for detection and monitoring of inflammatory lung diseases, including asthma. OBJECTIVES: To determine associations between EBC biomarkers and cytological and endoscopic definitions of lower airway inflammation whilst controlling for sampling and environmental variables...
June 19, 2018: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29917168/evaluation-of-anticancer-agents-using-patient-derived-tumor-organoids-characteristically-similar-to-source-tissues
#5
Hirosumi Tamura, Arisa Higa, Hirotaka Hoshi, Gen Hiyama, Nobuhiko Takahashi, Masae Ryufuku, Gaku Morisawa, Yuka Yanagisawa, Emi Ito, Jun-Ichi Imai, Yuu Dobashi, Kiyoaki Katahira, Shu Soeda, Takafumi Watanabe, Keiya Fujimori, Shinya Watanabe, Motoki Takagi
Patient-derived tumor xenograft models represent a promising preclinical cancer model that better replicates disease, compared with traditional cell culture; however, their use is low-throughput and costly. To overcome this limitation, patient-derived tumor organoids (PDOs) were established from human lung, ovarian and uterine tumor tissues, among others, to accurately and efficiently recapitulate the tissue architecture and function. PDOs were able to be cultured for >6 months, and formed cell clusters with similar morphologies to their source tumors...
June 18, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29917146/18f-fdg-pet-ct-for-invasive-fungal-infection-in-immunocompromised-patients
#6
Benjamin Leroy-Freschini, Giorgio Treglia, Xavier Argemi, Caroline Bund, Romain Kessler, Raoul Herbrecht, Alessio Imperiale
Background: Opportunistic invasive fungal infections (IFIs) comprise a heterogeneous spectrum of pathogens, whose early diagnosis remains challenging. Candida spp. and Aspergillus spp, the most frequent pathogens in immunocompromised patients, frequently affect lungs, liver, bone and skin. Aim: To evaluate the impact of 18F-FDG PET/CT in the management of immunocompromised patients with IFI. Design: A single-center retrospective study included 51 immunocompromised patients with IFI diagnosis undergoing 83 18F-FDG PET/CTs...
June 18, 2018: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29917126/genetic-susceptibility-to-thirdhand-smoke-induced-lung-cancer-development
#7
Bo Hang, Jian-Hua Mao, Antoine M Snijders
THS, the residual tobacco smoke remaining in the environment after tobacco has been smoked, represents an underestimated public health hazard. Evidence supports its widespread presence in indoor environments. Vulnerable populations are believed to include infants and children living in a smoking household exposed to THS and/or SHS and exposure has been identified as a risk factor for lung cancer later in life. These and future studies will provide novel and important evidence of how early-life exposure to THS affects cancer development and other diseases, which should be useful for framing and enforcing new policies against passive smoking in the the world...
June 16, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29917065/contribution-of-chronic-conditions-to-gender-disparities-in-health-expectancies-in-belgium-2001-2004-and-2008
#8
Renata T C Yokota, Willma J Nusselder, Jean-Marie Robine, Jean Tafforeau, Françoise Renard, Patrick Deboosere, Herman Van Oyen
Background: We aimed to investigate the contribution of chronic conditions to gender differences in disability-free life expectancy (DFLE) and life expectancy with disability (LED) in Belgium in 2001, 2004 and 2008. Methods: Data on disability and chronic conditions from participants of the 2001, 2004 and 2008 Health Interview Surveys in Belgium were used to estimate disability prevalence by cause using the attribution method. Disability prevalence was applied to life tables to estimate DFLE and LED using the Sullivan method...
June 15, 2018: European Journal of Public Health
https://www.readbyqxmd.com/read/29916965/spontaneous-pneumomediastinum-in-connective-tissue-diseases
#9
Federica De Giacomi, Misbah Baqir, Christian W Cox, Teng Moua, Eric L Matteson, Jay H Ryu
BACKGROUND: Spontaneous pneumomediastinum (SP) is an uncommon disorder but has been described in cases with connective tissue diseases (CTDs), most commonly dermatomyositis and polymyositis. We aimed to explore this relationship by analyzing the characteristics of CTD patients with SP. METHODS: Using a computer-assisted search, we identified 25 patients with CTD and SP evaluated between January 1997 and December 2016 at our institution. Clinicoradiologic characteristics, treatment, and outcomes were extracted and chest computed tomography studies analyzed...
June 18, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29916548/methylation-profiles-of-mir34-gene-family-in-vietnamese-patients-suffering-from-breast-and-lung-cancers
#10
Vo Thi Thuong Lan, Ho Van Son, Vu Lan Trang, Nguyen Thu Trang, Nguyen Thi Phuong, Nguyen Linh Toan, Pham Anh Thuy Duong
The three genes encoding small non‑coding microRNA (miR)34a, MIR34b and MIR34c act as tumor‑suppressor genes. Their aberrant expressions regulated by DNA methylation have been frequently found in various types of cancer. In the present study, the DNA promoter methylation profiles of the MIR34 gene family were analyzed using the methylation specific polymerase chain reaction in order to clarify their association with breast and lung cancer, non‑cancerous or normal adjacent tissues. The methylation frequency of MIR34a was significantly higher in breast cancer (49...
June 18, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29916280/similar-and-differential-canonical-pathways-and-biological-processes-associated-with-multiwalled-carbon-nanotube-and-asbestos-induced-pulmonary-fibrosis-a-1-year-postexposure-study
#11
Julian M Dymacek, Brandi N Snyder-Talkington, Rebecca Raese, Chunlin Dong, Salvi Singh, Dale W Porter, Barbara Ducatman, Michael G Wolfarth, Michal E Andrew, Lori Battelli, Vincent Castranova, Yong Qian, Nancy L Guo
Respiratory exposure to multiwalled carbon nanotubes (MWCNT) or asbestos results in fibrosis; however, the mechanisms to reach this end point may be different. A previous study by our group identified pulmonary effects and significantly altered messenger RNA (mRNA) signaling pathways following exposure to 1, 10, 40, and 80 µg MWCNT and 120 µg crocidolite asbestos on mouse lungs over time at 1-month, 6-month, and 1-year postexposure following pulmonary aspiration. As a continuation to the above study, this current study took an in-depth look at the signaling pathways involved in fibrosis development at a single time point, 1 year, and exposure, 40 µg MWCNT, the lowest exposure at which fibrosis was pathologically evident...
January 1, 2018: International Journal of Toxicology
https://www.readbyqxmd.com/read/29916090/cell-type-specific-expression-of-follistatin-like-1-fstl1-in-mouse-embryonic-lung-development
#12
Xue Liu, Yingying Liu, Zaofeng Yang, Wen Ning
Follistatin like-1 (Fstl1) is a secreted glycoprotein and can be up-regulated by TGF-β1. To better study the function of Fstl1 in lung development, we examined Fstl1 expression in the developing lung, in a cell type specific manner, using a tamoxifen inducible Fstl1-reporter mouse strain. Our results show that Fstl1 is ubiquitously expressed at saccular stage in the developing lung. At E18.5, Fstl1 expression is robust in most type of mesenchymal cells, including airway smooth muscle cells surrounding airways, vascular smooth muscle cells, endothelial cells, and vascular pericytes from blood vessel, but not PDGFRα+ fibroblasts in the distal alveolar sacs...
June 18, 2018: Journal of Molecular Histology
https://www.readbyqxmd.com/read/29916064/investigating-the-genetic-diversity-of-echinococcus-granulosus-sensu-stricto-with-new-microsatellites
#13
Gérald Umhang, Frédéric Grenouillet, Vanessa Bastid, Selim M'Rad, Benoît Valot, Myriam Oudni-M'Rad, Hamouda Babba, Franck Boué
Cystic echinococcosis is a zoonotic disease with worldwide distribution caused by the larval stage of the Cestode parasite Echinococcus granulosus sensu lato. Due to the predominance or even the exclusive presence of E. granulosus sensu stricto (s.s.) among E. granulosus species in many areas, the genetic diversity needs to be further investigated at the species level to better understand the inter- and intra-focus epidemiological features. Short sequences of mitochondrial or nuclear genes generally lack or have limited discriminatory power, hindering the detection of polymorphisms to reflect geographically based peculiarities and/or any history of infection...
June 18, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29915964/endoscopic-ultrasound-guided-transesophageal-thoracentesis-for-minimal-pleural-effusion
#14
Surinder Singh Rana, Ravi Sharma, Rajesh Gupta
BACKGROUND: Pleural effusion is a common finding both in patients with benign and malignant diseases of pleura and lung with diagnostic thoracentesis establishing the diagnosis in the majority of cases. The diagnostic thoracentesis can be done either blindly or under the guidance of ultrasound or computed tomography. However, minimal pleural effusion is difficult to sample even under image guidance. Endoscopic ultrasound (EUS) is known to detect smaller volume of pleural effusion and, thus, can help in guiding thoracentesis...
June 19, 2018: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/29915891/clinical-outcomes-of-african-american-patients-with-advanced-or-metastatic-non-small-cell-lung-cancer-on-nivolumab-in-a-single-community-based-cancer-center
#15
Andrew C Tiu, Rashmika Potdar, Djeneba Audrey Djibo, Muhammad Masab, Claudia Dourado
African Americans (AA) have the highest incidence and mortality rates with lung cancer. They are diagnosed at an earlier age with more advanced disease. Programmed cell death protein-1 inhibitor, Nivolumab, was approved as a second-line agent after failure of platinum-based therapy for advanced or metastatic non-small cell lung cancer (NSCLC). The original studies leading to the approval of Nivolumab had insufficient AA patients, thus there is still inadequate knowledge on treatment outcomes among AA patients...
June 18, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29915807/validating-a-commercial-device-for-continuous-activity-measurement-in-the-older-adult-population-for-dementia-management
#16
Tanvi Banerjee, Matthew Peterson, Quintin Oliver, Andrew Froehle, Larry Lawhorne
With the introduction of the large number of fitness devices on the market, there are numerous possibilities for their use in managing chronic diseases in older adults. For example, monitoring people with dementia using commercially available devices that measure heart rate, breathing rate, lung volume, step count, and activity level could be used to predict episodic behavioral and psychological symptoms before they become distressing or disruptive. However, since these devices are designed primarily for fitness assessment, validation of the sensors in a controlled environment with the target cohort population is needed...
January 2018: Smart Health
https://www.readbyqxmd.com/read/29915733/prevalence-of-pulmonary-artery-hypertension-in-patients-of-chronic-obstructive-pulmonary-disease-and-its-correlation-with-stages-of-chronic-obstructive-pulmonary-disease-exercising-capacity-and-quality-of-life
#17
Kamlesh Kumar Gupta, Bidyut Roy, Shyam Chand Chaudhary, Arvind Mishra, M L Patel, Jitendra Singh, Vivek Kumar
Background: Pulmonary arterial hypertension (PAH) is a complication of chronic obstructive pulmonary disease (COPD) in advance stages, and its presence indicates poor prognosis. Aims and Objective: The present study was design to know the prevalence of PAH in patients with COPD and its correlation with stages of COPD, exercising capacity, and quality of life. Materials and Methods: It is a cross-sectional prevalence study over a period of 1 year from August 2015 to July 2016...
January 2018: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29915691/establishment-of-a-12-gene-expression-signature-to-predict-colon-cancer-prognosis
#18
Dalong Sun, Jing Chen, Longzi Liu, Guangxi Zhao, Pingping Dong, Bingrui Wu, Jun Wang, Ling Dong
A robust and accurate gene expression signature is essential to assist oncologists to determine which subset of patients at similar Tumor-Lymph Node-Metastasis (TNM) stage has high recurrence risk and could benefit from adjuvant therapies. Here we applied a two-step supervised machine-learning method and established a 12-gene expression signature to precisely predict colon adenocarcinoma (COAD) prognosis by using COAD RNA-seq transcriptome data from The Cancer Genome Atlas (TCGA). The predictive performance of the 12-gene signature was validated with two independent gene expression microarray datasets: GSE39582 includes 566 COAD cases for the development of six molecular subtypes with distinct clinical, molecular and survival characteristics; GSE17538 is a dataset containing 232 colon cancer patients for the generation of a metastasis gene expression profile to predict recurrence and death in COAD patients...
2018: PeerJ
https://www.readbyqxmd.com/read/29915643/predictors-of-hospital-stay-in-normotensive-acute-pulmonary-embolism-a-retrospective-pilot-study
#19
Osama Mukhtar, Oday Alhafidh, Mazin Khalid, Jaspreet Kaler, Ebad Rahman, Binav Shrestha, Manal Bakhiet, Sumit Dahal, Bikash Bhattarai, Praveen Datar, Omar Abdulfattah, Vijay Gayam, Joseph Quist, Danilo Enriquez, Frances Schmidt
Introduction : The aim of our study is to determine the clinical, biochemical, and imaging factors that affect the duration of hospital stay in patients admitted with normotensive acute pulmonary embolism. Methods : This was a single-center retrospective study conducted in a community hospital in New York metropolitan area for patients admitted from October 2015 to October 2017. Results : A total of 79 patients were included, the mean age was 55.76 ( SD  = 17.33), 29 cases were males (37%) and 50 cases were females (63%)...
2018: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29915502/isolation-and-identification-of-mannheimia-haemolytica-by-culture-and-polymerase-chain-reaction-from-sheep-s-pulmonary-samples-in-shiraz-iran
#20
Mohammad Tabatabaei, And Fatemeh Abdollahi
Background and Aim: Mannheimia haemolytica is a Gram-negative, non-motile, and non-spore-forming rod-shaped coccobacillus bacterium. On blood agar plate, it shows complete hemolysis. This bacterium constitutes a part of normal flora of the upper respiratory system of ruminants. It is considered as the opportunistic pathogen and the main factor of pneumonic pasteurellosis, which has caused a severe economic loss in sheep and cattle industries. Considering the prevalence of the disease in sheep and goat population in the dry and hot regions of the country in general and in Fars province in particular in the form of pneumonia, the purpose of this study was to isolate and identify the bacterium M...
May 2018: Veterinary World
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