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https://www.readbyqxmd.com/read/28324265/cardiac-safety-efficacy-and-correlation-of-serial-serum-her2-extracellular-domain-shed-antigen-measurement-with-the-outcome-of-the-combined-trastuzumab-plus-cmf-in-women-with-her2-positive-metastatic-breast-cancer-results-from-the-eortc-10995-phase-ii-study
#1
Konstantinos Tryfonidis, S Marreaud, H Khaled, B De Valk, J Vermorken, M Welnicka-Jaskiewicz, K Aalders, J M S Bartlett, L Biganzoli, J Bogaerts, David Cameron
PURPOSE: Cardiotoxicity is a side effect of trastuzumab. We assessed efficacy and cardiac safety of CMF with trastuzumab (CMF+T) in HER2-positive metastatic breast cancer patients (MBC). METHODS: In this phase II study, centrally confirmed, previously treated HER2-positive MBC patients with measurable disease (per RECIST v 1.0) were enrolled. Initially, patients were randomized between 8 CMF cycles alone or combined with trastuzumab during chemotherapy, followed by 3-weekly trastuzumab maintenance till progression...
March 21, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28323999/metabolically-healthy-obesity-and-ischemic-heart-disease-a-10-year-follow-up-of-the-inter99-study
#2
Louise Hansen, Marie K Netterstrøm, Nanna B Johansen, Pernille F Rønn, Dorte Vistisen, Lise Ln Husemoen, Marit E Jørgensen, Naja H Rod, Kristine Færch
Context: Recent studies have suggested that a subgroup of obese individuals is not at increased risk of obesity-related complications. This subgroup has been referred to as metabolically healthy obese. Objective: To investigate whether obesity is a risk factor for development of ischemic heart disease (IHD) irrespective of metabolic health. Design: 6,238 men and women from the Danish prospective Inter99 study were followed during 10.6 (SD 1...
March 7, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28323928/physical-activity-vitamin-d-and-incident-atherosclerotic-cardiovascular-disease-in-whites-and-blacks-the-aric-study
#3
Kathleen Chin, Di Zhao, Martin Tibuakuu, Seth S Martin, Chiadi E Ndumele, Roberta Florido, B Gwen Windham, Eliseo Guallar, Pamela L Lutsey, Erin D Michos
Context: Physical activity (PA) is associated with 25-hydroxyvitamin D [25(OH)D] levels. Both are associated with atherosclerotic cardiovascular disease (ASCVD), but their joint association with ASCVD risk is unknown. Objective: To examine the dose-response between PA and 25(OH)D, and to assess effect modification of 25(OH)D and PA with ASCVD risk. Design: Cross-sectional and prospective study using Poisson and linear regression. Setting: Community-dwelling Atherosclerosis Risk in Communities cohort...
February 17, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28323625/the-effects-of-stretching-training-on-cardiac-autonomic-function-in-obese-postmenopausal-women
#4
Alexei Wong, Marcos Sanchez-Gonzalez, Roy Kalfon, Stacey Alvarez-Alvarado, Arturo Figueroa
Context • Menopause and obesity are associated with autonomic dysfunction. Unconventional exercise modalities that include an important flexibility component seem to improve cardiac autonomic function by lowering sympathetic tone and increasing vagal modulation of the heart rate (HR). Yet clear evidence of the effects of stretching training (ST) on cardiac autonomic modulation is limited. Objective • The present study intended to examine the effects of ST on HR variability (HRV) and flexibility in obese postmenopausal women...
March 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28319436/estimating-the-risks-of-breast-cancer-radiotherapy-evidence-from-modern-radiation-doses-to-the-lungs-and-heart-and-from-previous-randomized-trials
#5
Carolyn Taylor, Candace Correa, Frances K Duane, Marianne C Aznar, Stewart J Anderson, Jonas Bergh, David Dodwell, Marianne Ewertz, Richard Gray, Reshma Jagsi, Lori Pierce, Kathleen I Pritchard, Sandra Swain, Zhe Wang, Yaochen Wang, Tim Whelan, Richard Peto, Paul McGale
Purpose Radiotherapy reduces the absolute risk of breast cancer mortality by a few percentage points in suitable women but can cause a second cancer or heart disease decades later. We estimated the absolute long-term risks of modern breast cancer radiotherapy. Methods First, a systematic literature review was performed of lung and heart doses in breast cancer regimens published during 2010 to 2015. Second, individual patient data meta-analyses of 40,781 women randomly assigned to breast cancer radiotherapy versus no radiotherapy in 75 trials yielded rate ratios (RRs) for second primary cancers and cause-specific mortality and excess RRs (ERRs) per Gy for incident lung cancer and cardiac mortality...
March 20, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28318855/disability-adjusted-life-years-lost-due-to-ischemic-heart-disease-in-mainland-portugal-2013
#6
Ana Henriques, Carla Araújo, Marta Viana, Olga Laszczynska, Marta Pereira, Kathleen Bennett, Nuno Lunet, Ana Azevedo
INTRODUCTION AND OBJECTIVES: Estimates of the burden of ischemic heart disease (IHD), including geographic differences, should support health policy decisions. We set out to estimate the burden of IHD in mainland Portugal in 2013 by calculating disability-adjusted life years (DALYs) and to compare this burden between five regions. METHODS: Years of life lost (YLLs) were calculated by multiplying the number of IHD deaths in 2013 (Statistics Portugal) by the life expectancy at the age at which death occurred...
March 16, 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/28315864/vitamin-d-status-gender-differences-and-cardiometabolic-health-disparities
#7
Dharambir K Sanghera, Bishwa R Sapkota, Christopher E Aston, Piers R Blackett
BACKGROUND: Vitamin D deficiency is an unrecognized epidemic found in India and also worldwide. Despite the high prevalence of diabetes among Indians, there is a paucity of data showing the relationship between vitamin D status and cardiometabolic disparities. In this study, we have examined the relationship between vitamin D and cardiometabolic traits in a population from India. METHODS: Circulating 25(OH)D levels were measured in 3,879 participants from the Asian Indian Diabetic Heart Study using ELISA kits...
March 18, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28315569/algorithm-for-predicting-chd-death-risk-in-turkish-adults-conventional-factors-contribute-only-moderately-in-women
#8
Altan Onat, Günay Can, Ayşem Kaya, Muhammed Keskin, Mert I Hayıroğlu, Hüsniye Yüksel
OBJECTIVE: To assist the management strategy of individuals, we determined an algorithm for predicting the risk of coronary heart disease (CHD) death in Turkish adults with a high prevalence of metabolic syndrome (MetS). METHODS: The risk of CHD death was estimated in 3054 middle-aged adults, followed over 9.08±4.2 years. Cox proportional hazard regression was used to predict risk. Discrimination was assessed using C-statistics. RESULTS: CHD death was identified in 233 subjects...
March 9, 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/28315565/heart-rate-variability-in-normal-weight-patients-with-polycystic-ovary-syndrome
#9
Celal Kilit, Türkan Paşalı Kilit
OBJECTIVE: Polycystic ovary syndrome (PCOS) is an endocrine disease closely related to several risk factors of cardiovascular disease. Obese women with PCOS show altered autonomic modulation. The results of studies investigating cardiac autonomic functions of normal-weight women with PCOS are conflicting. The aim of the study was to assess the reactivity of cardiac sympathovagal balance in normal-weight women with PCOS by heart rate variability analysis. METHODS: We examined the heart rate variability in 60 normal-weight women with PCOS and compared them with that in 60 age-matched healthy women having a similar metabolic profile...
March 9, 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/28314442/-adult-congenital-heart-disease-medical-and-psychosocial-issues
#10
Magalie Ladouceur, Florence Pontnau, Laurence Iserin
The population of adults with congenital heart disease (ACHD) is continuously increasing with now a higher prevalence than that of the pediatric population. This concerns above all complex congenital heart diseases. Heart failure is the primary cause of death followed by arrhythmia, which is very common in ACHD. A specialized follow-up by dedicated centers is significantly associated with an improvement of survival of ACHD patients compared to non-expert follow-up. Extracardiac disorders (liver, kidney, respiratory) are frequent and require an accurate and specific management...
March 14, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/28314425/characteristics-of-hearts-at-necropsy-in-patients-treated-chronically-with-prednisone-the-corticosteroid-heart
#11
William C Roberts, Vera S Won, Anupama Vasudevan, Joseph M Guileyardo
It is known that long-term corticosteroid therapy increases fatty deposits in several human tissues. To quantify the quantity of fatty deposits in the heart in patients on prednisone, we examined the heart at necropsy in 37 patients who had received long-term corticosteroid therapy (prednisone in 34) and compared certain findings in them to those in 194 (steroid-naïve) patients also studied at necropsy at Baylor University Medical Center, Dallas, in a 3-year period (2013, 2014, and 2015). Significant differences between the 2 groups were found in age, gender, and frequency of coronary artery disease but not in body mass index, frequency of massive cardiac adiposity, heart weight, or frequency of systemic hypertension or diabetes mellitus...
December 15, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/28306702/self-management-program-for-heart-healthy-behavior-among-middle-and-old-aged-korean-women-at-risk-for-metabolic-syndrome
#12
Nah-Mee Shin, JiWon Choi, InHae Cho, Byung-Jun Park
BACKGROUND: The prevalence of metabolic syndrome (MetS) has been increasing among Koreans, and middle-aged and older women are at risk of metabolic syndrome. Effective strategies to promote lifestyle modification need to be developed. OBJECTIVE: We examined the effects of a self-management program on improving the cardiovascular health status and promoting healthy behaviors among overweight or obese Korean women at risk of metabolic syndrome. METHODS: A pretest and posttest intervention design was used...
March 17, 2017: Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/28306696/n-terminal-fragment-of-b-type-natriuretic-peptide-predicts-coexisting-subclinical-heart-and-vessel-disease
#13
Luigi E Pastormerlo, Stefano Maffei, Daniele Della Latta, Vladislav Chubuchny, Carla Susini, Sergio Berti, Concetta Prontera, Simona Storti, Claudio Passino, Emilio Pasanisi, Michele Emdin, Dante Chiappino
BACKGROUND: Identification of preclinical cardiovascular disease represents a challenge. We evaluate N-terminal proB-type natriuretic peptides (NT-proBNP) as markers of both cardiac and vascular subclinical disease in a community-based study including asymptomatic middle- aged study participants. METHODS AND RESULTS: In total, 807 study participants without previous cardiovascular disease were recruited. They underwent thorough laboratory assessment (including NT-proBNP), ultrasound examination of heart and evaluation of coronary calcium score and carotid intima-media thickness, by computed tomography and ultrasound, respectively...
March 16, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28306633/race-and-sex-differences-in-cardiovascular-%C3%AE-adrenergic-and-%C3%AE-adrenergic-receptor-responsiveness-in-men-and-women-with-high-blood-pressure
#14
Andrew Sherwood, LaBarron K Hill, James A Blumenthal, Kristy S Johnson, Alan L Hinderliter
OBJECTIVE: Hypertension is associated with unfavorable changes in adrenergic receptor responsiveness, but the relationship of race and sex to adrenergic receptor responsiveness in the development of cardiovascular disease is unclear. This study examined α-adrenergic and ß-adrenergic receptor responsiveness in African-American and white men and women with untreated high blood pressure (BP) (HBP) and with normal BP. METHODS AND RESULTS: The study sample comprised 161 African-American and white men and women in the age range 25-45 years...
March 16, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28301892/evaluating-the-performance-of-ultrasound-screening-for-congenital-heart-disease-a-descriptive-cohort-study
#15
Rosemary J Froehlich, Lindsay Maggio, Phinnara Has, Erika F Werner, Dwight J Rouse
Objective The objective of this study was to evaluate the rate of abnormal fetal echocardiogram after normal detailed anatomy ultrasound when both are performed by maternal-fetal medicine specialists. Study Design Retrospective review of women who underwent detailed anatomy ultrasound and fetal echocardiography between 16 and 26 weeks' gestation at a single center. Women included had at least one indication for fetal echocardiography as recommended by the American Institute of Ultrasound in Medicine and normal cardiac anatomy on initial detailed anatomy ultrasound...
March 16, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28301860/it-is-a-painful-somatic-symptom-not-the-history-of-cancer-malignancy-that-is-associated-with-depression-findings-from-multiple-national-surveys
#16
Krystina Johnson, Maria D Politis, Andrew R Hansen, Lindsey E McKenzie, Dustin T Duncan, Jian Zhang
Medical case management has improved in the past few decades, changing the dynamic interaction between depression and prevalent medical diseases. It is relevant to describe the comorbidity between depression and medical diseases to further improve the effectiveness of case management. We analyzed the data of adults aged 20 years and older, who completed depression screening as a part of the National Health and Nutrition Examination Survey, 2005 to 2012. Depression was ascertained using the Patient Health Questionnaire, a 9-item screening instrument asking about the frequency of depression symptoms over the past 2 weeks...
April 2017: Pain
https://www.readbyqxmd.com/read/28300627/serum-uric-acid-is-associated-with-better-executive-function-in-men-but-not-in-women-baseline-assessment-of-the-elsa-brasil-study
#17
Cristina Pellegrino Baena, Claudia Kimie Suemoto, Sandhi Barreto, Paulo Lotufo, Isabela Benseñor
BACKGROUND: Serum uric acid (SUA) may protect against free radical stress damage and was previously linked to cognitive impairment in older adults, but evidence in middle-aged adults is scarce. PURPOSE: We sought to analyze whether SUA is associated with cognitive performance in apparently healthy middle-aged participants in the ELSA-Brasil cohort study. METHODS: We excluded participants older than age 65, those taking allopurinol, benzbromarone, or medications that could impair cognitive performance, those with previous stroke, and those with incomplete data on cognitive tests or SUA...
March 11, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28298859/changes-in-intraocular-pressure-after-exercise-test
#18
Morteza Abdar Esfahani, Mojgan Gharipour, Hamid Fesharakinia
BACKGROUND: The decrease in intraocular pressure (IOP) within exercise has been recently suggested; however, this change remained ambiguous following exercise test. The present study aimed to assess changes in IOP induced by exercise test in patients who suspected to coronary artery disease (CAD) and indicated for exercise test evaluation. METHODS: In a cross-sectional study at the cardiovascular research center of Amin Heart Hospital in Isfahan, 101 eyes from 51 consecutive patients suspected to CAD aged 30-70 years referred for exercise testing were evaluated...
January 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/28294867/-comparative-prospective-clinical-economic-study-of-original-and-generic-bisoprolol-in-patients-with-coronary-heart-disease
#19
E I Tarlovskaya, T I Chudinovskih
PURPOSE: to conduct comparative clinical and economical analysis of original and generic preparations of bisoprolol. MATERIALS AND METHODS: The study included 61 patients after acute coronary syndrome (ACS) (34 men, 27 women, age 46-78 years). Patients were distributed (envelope method) to 2 groups. Patients of group A received original bisoprolol, of group C - generic drug. Duration of observation was 6 weeks. Parameters analyzed were dynamics of heart rate (HR), data of treadmill exercise test, and values of calculated cost/effectiveness ratio...
May 2016: Kardiologiia
https://www.readbyqxmd.com/read/28292514/similarities-and-differences-between-coronary-heart-disease-and-stroke-in-the-associations-with-cardiovascular-risk-factors-the-japan-collaborative-cohort-study
#20
Masaaki Matsunaga, Hiroshi Yatsuya, Hiroyasu Iso, Kentaro Yamashita, Yuanying Li, Kazumasa Yamagishi, Naohito Tanabe, Yasuhiko Wada, Chaochen Wang, Atsuhiko Ota, Koji Tamakoshi, Akiko Tamakoshi
BACKGROUND AND AIMS: Coronary heart disease (CHD) and stroke have common risk factors, but some of these differ in the magnitude or direction of associations between CHD and stroke. We assessed whether the impact of each risk factor differed between CHD and stroke mortality in Asians. METHODS: In total, 104 910 subjects aged 40-79 years without histories of cancer, CHD and stroke at baseline were followed between 1988 and 2009. Competing-risks analysis was used to test for differences in the associations of each risk factor with two endpoints (CHD and stroke)...
March 6, 2017: Atherosclerosis
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