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Joseph N Trachtman, Vincent Pagano
We describe a patient who developed symptoms of headache, fatigue, and dizziness after administration of terbinafine (Lamisil). Laboratory tests revealed that he is heterozygous for the C677T variation of the methylenetetrahydrofolate reductase genetic mutation. The prescription of Deplin (L-methylfolate) greatly reduced the symptoms. It was later noted that Lamisil's mechanism of action interferes with cells' methylation cycle, which we suspect compromises cellular function in people with the methylenetetrahydrofolate reductase genetic mutation...
December 2015: Therapeutic Drug Monitoring
Richard C Shelton, J Sloan Manning, Lori W Barrentine, Eleanor V Tipa
OBJECTIVE: l-Methylfolate has been shown in retrospective and prospective studies to enhance antidepressant response. The aim of this study was to prospectively assess change in depression severity and medication satisfaction in patients prescribed l-methylfolate within a naturalistic setting. METHOD: Between November 2010 and April 2012, patients who reported being treated for major depressive disorder rated their experiences before and after 3 months on the prescription medical food l-methylfolate (Deplin) 7...
2013: Primary Care Companion to CNS Disorders
(no author information available yet)
No abstract text is available yet for this article.
April 19, 2010: Medical Letter on Drugs and Therapeutics
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