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https://www.readbyqxmd.com/read/29905921/pediatric-inpatient-and-emergency-dermatology-consultations-a-5-year-retrospective-analysis
#1
Mariana Cruz-Manzano, Cristina N Brau-Javier, Sheila Valentín-Nogueras, Luz D Figueroa-Guzmán
OBJECTIVE: To characterize and analyze the inpatient and emergency pediatric dermatology consults in our academic hospital center. METHODS: We reviewed 485 consultations that were done by the University of Puerto Rico Department of Dermatology from July 2007 to June 2012. The date, patient age and gender, consulting service, presumptive diagnosis, final diagnosis, and diagnostic procedures performed were documented for each consult. RESULTS: The patients' ages ranged from newborn to 18 years; the 13 to 18 years age group was the most common (29%)...
June 2018: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/29885800/malassezia-pachydermatis-from-animals-planktonic-and-biofilm-antifungal-susceptibility-and-its-virulence-arsenal
#2
Raimunda Sâmia Nogueira Brilhante, Maria Gleiciane da Rocha, Glaucia Morgana de Melo Guedes, Jonathas Sales de Oliveira, Géssica Dos Santos Araújo, Jaime David Acosta España, Jamille Alencar Sales, Lara de Aguiar, Manoel de Araújo Neto Paiva, Rossana de Aguiar Cordeiro, Waldemiro de Aquino Pereira-Neto, Adriana de Queiroz Pinheiro, José Júlio Costa Sidrim, Débora de Souza Collares Maia Castelo-Branco, Marcos Fábio Gadelha Rocha
The yeast Malassezia pachydermatis is a component of the microbiota of dogs and cats, however it can cause otitis and seborrheic dermatitis in these animals. The objective of this study was to determine the antifungal susceptibility, and evaluate virulence and pathogenicity of 25 M. pachydermatis strains from animals. Susceptibility to ketoconazole, fluconazole, itraconazole, voriconazole, terbinafine, and amphotericin B was evaluated by broth microdilution assay. In addition, biofilm-forming ability, protease, phospholipase, hemolysin and melanin production and adhesion to epithelial cells by this yeast species were assessed...
July 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29877593/a-systematic-literature-review-of-the-human-skin-microbiome-as-biomarker-for-dermatological-drug-development
#3
REVIEW
T van der Kolk, H E C van der Wall, C Balmforth, M B A Van Doorn, R Rissmann
AIMS: To explore the potential of the skin microbiome as biomarker in six dermatological conditions i.e. atopic dermatitis (AD), acne vulgaris (AV), psoriasis vulgaris (PV), hidradenitis suppurativa (HS), seborrheic dermatitis/pityriasis capitis (SD/PC) and ulcus cruris (UC). METHODS: A systematic literature review was conducted according to the PRISMA guidelines. Two investigators independently reviewed the included studies and ranked the suitability microbiome implementation for early phase clinical studies in an adapted GRADE method...
June 7, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29808609/pigmented-transverse-nasal-band-a-distinct-presentation
#4
Vijay Zawar, Snehal Daga, Manoj Pawar, Shrikant Kumavat
Pigmented transverse nasal band (PTNB) is an interesting morphological entity mainly of cosmetic concern. It is believed to be related to a defect in the development of the nasal cartilages and bones from childhood to adolescence. Some patients may have genetic predisposition. It is asymptomatic in nature and may be associated with certain dermatological conditions such as seborrheic diathesis, dermatosis papulosa nigra, ichthyosis, atopic dermatitis, acne vulgaris, psoriasis, and seborrheic melanosis.
May 28, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29807522/current-state-of-nanomedicines-in-the-treatment-of-topical-infectious-disorders
#5
Kanika Thakur, Gajanand Sharma, Bhupinder Singh, Sanjay Chhibber, Om Prakash Katare
BACKGROUND: Topical infections, involving a number of diseases such as impetigo, eczema, pustular acne, psoriasis and infected seborrheic dermatitis are one among the many challenges to health which stand out for their profound impact on human species. The treatment of topical infections has always been a difficult proposition because of the lack of efficacy of existing anti-infectives, longer period of treatment and yet incomplete recovery. The increasing emergence of antibiotic resistant bacterial strains like Staphylococcus aureus, Methicillin-Resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa undermine the need of development of new delivery systems to enhance the therapeutic efficacy of existing topical anti-infectives...
May 28, 2018: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/29806976/analysis-of-gene-expression-profiles-of-multiple-skin-diseases-identifies-a-conserved-signature-of-disrupted-homeostasis
#6
Kevin J Mills, Michael K Robinson, Joseph D Sherrill, Daniel J Schnell, Jun Xu
Triggers of skin disease pathogenesis vary, but events associated with the elicitation of a lesion share many features in common. Our objective was to examine gene expression patterns in skin disease to develop a molecular signature of disruption of cutaneous homeostasis. Gene expression data from common inflammatory skin diseases (e.g., psoriasis, atopic dermatitis, seborrheic dermatitis and acne), and a novel statistical algorithm were used to define a unifying molecular signature referred to as the "Unhealthy Skin Signature" (USS)...
May 28, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29790104/beneficial-effects-of-antioxidant-furfuryl-palmitate-in-non-pharmacologic-treatments-prescription-emollient-devices-peds-for-atopic-dermatitis-and-related-skin-disorders
#7
REVIEW
Paolo Daniele Pigatto, Marco Diani
INTRODUCTION: Atopic dermatitis (AD) is a common chronic inflammatory skin disease; it requires long-term treatments focused on symptomatic relief. Current first-line treatments include moisturizers and topical corticosteroids. Recently, topical antioxidants have been added to moisturizer formulations to alleviate mild-to-moderate AD. The aim of this review was to evaluate the efficacy and tolerability of furfuryl palmitate, a new antioxidant molecule, and furfuryl derivatives. METHODS: A PubMed/Google Scholar search was conducted using the term "furfuryl palmitate" (and its derivatives, including AR-GG27® ) combined with "skin," "atopic dermatitis," and "atopic eczema...
May 22, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29785324/-staphylococcus-aureus-is-the-most-common-bacterial-agent-of-the-skin-flora-of-patients-with-seborrheic-dermatitis
#8
Funda Tamer, Mehmet Eren Yuksel, Evren Sarifakioglu, Yavuz Karabag
Background: Seborrheic dermatitis is an inflammatory skin disease that affects 1-3% of the general population. The Malassezia species has been implicated as the main causative agent; however, the bacterial flora of the skin may also play role in the etiopathogenesis. Therefore, we investigated the most common bacterial agent of the skin flora of patients with seborrheic dermatitis. Materials and Methods: Fifty-one patients with seborrheic dermatitis and 50 healthy individuals are included in this study...
April 2018: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/29754885/langerhans-cell-histiocytosis-in-children-history-classification-pathobiology-clinical-manifestations-and-prognosis
#9
REVIEW
Jolie Krooks, Milen Minkov, Angela G Weatherall
Langerhans cell histiocytosis (LCH) is an inflammatory neoplasia of myeloid precursor cells driven by mutations in the mitogen-activated protein kinase pathway. When disease involves the skin, LCH most commonly presents as a seborrheic dermatitis or eczematous eruption on the scalp and trunk. Evaluation for involvement of other organ systems is essential, because 9 of 10 patients presenting with cutaneous disease also have multisystem involvement. Clinical manifestations range from isolated disease with spontaneous resolution to life-threatening multisystem disease...
June 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29742192/chronic-nasolabial-fold-seborrheic-dermatitis-successfully-controlled-with-crisaborole
#10
Dede Liu, Peter Chow, Sarah Strawn, Anand Rajpara, Ting Wang, Daniel Aires
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May 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29737895/treatment-of-seborrheic-dermatitis-a-comprehensive-review
#11
Luis J Borda, Marina Perper, Jonette E Keri
Seborrheic Dermatitis (SD) is a chronic, recurring inflammatory skin disorder that manifests as erythematous macules or plaques with varying levels of scaling associated with pruritus. The condition typically occurs as an inflammatory response to Malassezia species and tends to occur on seborrheic areas, such as the scalp, face, chest, back, axilla, and groin areas. SD treatment focuses on clearing signs of the disease; ameliorating associated symptoms, such as pruritus; and maintaining remission with long-term therapy...
May 8, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29727474/high-prevalence-and-correlates-of-human-herpesvirus-6a-in-nevocytic-nevus-and-seborrheic-diseases-implication-from-a-pilot-study-of-skin-patient-tissues-in-shanghai
#12
Ling Ding, Xiaohui Mo, Liming Zhang, Feng Zhou, Caixia Zhu, Yuyan Wang, Cankun Cai, Yeqiang Liu, Fang Wei, Qiliang Cai
Skin disorders vary greatly in symptom and severity, and the causes of these disorders are largely unknown. Human herpesvirus (HHV) has been shown to cause many diseases. However, the prevalence and correlation of each HHV infection with different skin disorders remains obscure. To reveal the potential link of a certain type of skin disease with herpesvirus infection, a total of 272 patient tissues with inflammatory or neoplastic skin diseases including 7 subtypes in Shanghai, China, were investigated. We found that the overall prevalence of HHV-6A in inflammatory or neoplastic skin tissues is the most common (40...
May 4, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29724618/missed-opportunities-in-the-diagnosis-of-human-immunodeficiency-virus-infection-in-the-region-of-aragon-late-diagnosis-importance
#13
César Gargallo-Bernad, Francisco Javier Sangrós-González, Piedad Arazo-Garcés, Rosa Martínez-Álvarez, Carmen Malo-Aznar, Alicia Gargallo-Bernad, Alba Ballester-Luna, Luis Eduardo Cabrero-Pascual, Pablo Gil-Orna, Víctor José Abadía-Gallego, Isabel Torres-Peña, Héctor Ordiz-Suárez
INTRODUCTION: Late Diagnosis (LD) of Human Immunodeficiency Virus (HIV) infection (CD4 lymphocytes <350/μl at diagnosis of the disease), deteriorates the condition of those affected and increases the probability of transmission. The objective of the present study was to analyse the prevalence of LD, to identify missed diagnostic opportunities (MDO) and to find out which level of the health care delivery system they took place. METHODS: Retrospective, observational and descriptive study of the population diagnosed with infection of HIV/AIDS in the period 2011-2015 in Aragon...
April 30, 2018: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29670385/the-efficacy-of-a-pseudo-ceramide-and-eucalyptus-extract-containing-lotion-on-dry-scalp-skin
#14
Yutaka Takagi, Xuanhe Ning, Akihiko Takahashi, Chiaki Ishizaki, Takahiro Nishizaka, Kazuhiro Kaizu, Masahiro Miyaki, Hotaka Yamamuro, Makoto Kawashima
Objective: Dry and scaly conditions on the scalp are often observed in patients with atopic dermatitis, seborrheic dermatitis and/or pityriasis capitis. Those scalp lesions often exhibit low barrier function and reduced ceramide levels. Therefore, a clinical study was conducted to evaluate the efficacy of topical application of a pseudo-ceramide and eucalyptus extract-containing lotion on the scalps of patients with skin diseases. Methods: Thirty-four subjects participated in this study (atopic dermatitis: 19 subjects; seborrheic dermatitis: 6 subjects; pityriasis capitis: 9 subjects)...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29566918/causes-pathophysiology-and-treatment-of-pruritus-in-the-mature-patient
#15
Alina Shevchenko, Rodrigo Valdes-Rodriguez, Gil Yosipovitch
Chronic itch is a common and debilitating health condition in the elderly. There are several common causes of itch in the mature population, such as skin xerosis, immunosenescence, and neuropathic changes. In addition, skin diseases, such as seborrheic dermatitis and stasis dermatitis, systemic conditions (end-stage renal disease and diabetes), or psychogenic derailments, such as depression, anxiety, and dementia, can all serve as triggers of pruritus. Polypharmacy, a common occurrence among the elderly population, may also serve as a cause of itch that may or may not be accompanied by dermatitis...
March 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29499796/evaluating-and-optimizing-the-diagnosis-of-erythematotelangiectatic-rosacea
#16
REVIEW
Mohammed D Saleem, Jonathan K Wilkin
Erythematotelangiectatic rosacea is the most prevalent rosacea subtype. Multiple dermatologic conditions may mimic erythematotelangiectatic rosacea. The authors review a comprehensive approach to evaluating subjects with a suspected diagnosis of erythematotelangiectatic rosacea and discuss findings that may warrant further investigation. Differential diagnoses can be narrowed based on the presence of characteristics such as transient erythema, nontransient erythema, and telangiectasias. A thorough history and physical examination are critical in ruling out conditions such as dermatomyositis, lupus erythematosus, atopic dermatitis, and seborrheic dermatitis...
April 2018: Dermatologic Clinics
https://www.readbyqxmd.com/read/29423841/treatment-of-flat-and-elevated-pigmented-disorders-with-a-755-nm-alexandrite-picosecond-laser-clinical-and-histological-evaluation
#17
Adrian Alegre-Sanchez, Natalia Jiménez-Gómez, Óscar M Moreno-Arrones, Pablo Fonda-Pascual, Bibiana Pérez-García, Pedro Jaén-Olasolo, Pablo Boixeda
The novel picosecond lasers, initially developed for faster tattoo removal, have also shown great efficacy in endogenous pigmentary disorders. To describe the efficacy and safety profile of an alexandrite (755-nm) picosecond laser in a wide range of pigmented flat and elevated cutaneous lesions. A retrospective study was performed in which we collected all the clinical images of patients treated with the 755-nm alexandrite picosecond laser for 12 months (November 2016-November 2017). Clinical features were obtained from their medical charts...
February 9, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29410727/scalp-seborrheic-dermatitis-and-dandruff-therapy-using-a-herbal-and-zinc-pyrithione-based-therapy-of-shampoo-and-scalp-lotion
#18
Deganit Barak-Shinar, Lawrence J Green
Objective: The aim of this study was to evaluate the safety and efficacy of an herbal and zinc pyrithione shampoo and a scalp lotion (Kamedis Derma-Scalp Dandruff Therapy, Kamedis Ltd., Tel Aviv, Israel) for the treatment of scalp seborrheic dermatitis and dandruff. Design: This was an interventional, open-label, safety and efficacy study. Setting: This open-label study was conducted at Consumer Product Testing Company Inc. in Fairfield, New Jersey. At the baseline visit (Day 0), an examination of the scalp was conducted by a board-certified dermatologist...
January 2018: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29365241/pityriasis-rosea-diagnosis-and-treatment
#19
Jose M Villalon-Gomez
Pityriasis rosea is a common self-limiting rash that usually starts with a herald patch on the trunk and progresses along the Langer lines to a generalized rash over the trunk and limbs. The diagnosis is based on clinical and physical examination findings. The herald patch is an erythematous lesion with an elevated border and depressed center. The generalized rash usually presents two weeks after the herald patch. Patients can develop general malaise, fatigue, nausea, headaches, joint pain, enlarged lymph nodes, fever, and sore throat before or during the course of the rash...
January 1, 2018: American Family Physician
https://www.readbyqxmd.com/read/29243825/dermatologic-manifestations-among-human-immunodeficiency-virus-patients-in-morocco-and-association-with-immune-status
#20
Hicham Titou, Christelle Ebongo, Naoufal Hjira
OBJECTIVE: The objective was to determine if the type and number of skin diseases can be clinical indicators of underlying immune status in HIV1 disease by estimating and correlating with the CD4 count and CDC stage. MATERIALS AND METHODS: This was a retrospective cross-sectional descriptive study. All consecutive patients infected with HIV1 followed at the Dermatology Department of Rabat Military Hospital between January 2008 and January 2017 were studied for dermatological manifestations, CD4 count and CDC clinical stage...
February 2018: International Journal of Dermatology
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