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heart atack

Tao Yang, Thomas C Atack, Dina Myers Stroud, Wei Zhang, Lynn Hall, Dan M Roden
RATIONALE: Although the sodium channel locus SCN10A has been implicated by genome-wide association studies as a modulator of cardiac electrophysiology, the role of its gene product Nav1.8 as a modulator of cardiac ion currents is unknown. OBJECTIVE: We determined the electrophysiological and pharmacological properties of Nav1.8 in heterologous cell systems and assessed the antiarrhythmic effect of Nav1.8 block on isolated mouse and rabbit ventricular cardiomyocytes...
July 20, 2012: Circulation Research
Hiroshi Watanabe, Tao Yang, Dina Myers Stroud, John S Lowe, Louise Harris, Thomas C Atack, Dao W Wang, Susan B Hipkens, Brenda Leake, Lynn Hall, Sabina Kupershmidt, Nagesh Chopra, Mark A Magnuson, Naohito Tanabe, Björn C Knollmann, Alfred L George, Dan M Roden
BACKGROUND: The D1275N SCN5A mutation has been associated with a range of unusual phenotypes, including conduction disease and dilated cardiomyopathy, as well as atrial and ventricular tachyarrhythmias. However, when D1275N is studied in heterologous expression systems, most studies show near-normal sodium channel function. Thus, the relationship of the variant to the clinical phenotypes remains uncertain. METHODS AND RESULTS: We identified D1275N in a patient with atrial flutter, atrial standstill, conduction disease, and sinus node dysfunction...
August 30, 2011: Circulation
J R Atack, S M Cook, A P Watt, C I Ragan
An anion-exchange HPLC mass assay was used to characterize Swiss-Webster mouse brain and peripheral tissue inositol(1)phosphate [Ins(1)P]levels. Ins(1)P was identified in all tissues studied but Ins(4)P could be identified only in brain, and then only as a part of a peak containing an additional, unidentified component. As a result, it was not possible to quantify Ins(4)P levels. Following a single subcutaneous dose of lithium (10 mmol/kg), brain Ins(1)P levels were maximally elevated after 6 h (corresponding to peak brain lithium concentrations) and were increased to levels 35- and 20-fold higher than in saline-treated animals in cholinergic agonist (pilocarpine)-stimulated and unstimulated animals, respectively...
November 1992: Journal of Neurochemistry
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