Yohei Tomaru, Hisashi Sugaya, Tomokazu Yoshioka, Norihito Arai, Tomoyuki Abe, Yuta Tsukagoshi, Hiroshi Kamada, Masashi Yamazaki, Hajime Mishima
This preliminary study investigated the efficacy and safety of bone marrow-derived mesenchymal stem cell transplantation in a piglet Legg-Calve-Perthes disease (LCPD) model. The LCPD model was induced in two Landrace piglets (6- and 7-week-old, weighing 12 and 17 kg, respectively) by ligaturing the femoral neck. In the first piglet, the natural LCPD course was observed. In the second piglet, 4 weeks after ligaturing the femoral neck, simple medium and medium containing 2.44 × 107 bone marrow-derived mesenchymal stem cells were transplanted into the right and left femoral heads after core decompression, respectively...
May 22, 2023: Journal of Pediatric Orthopedics. Part B