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https://www.readbyqxmd.com/read/28814063/icave-an-open-source-tool-for-visualizing-biomolecular-networks-in-3d-stereoscopic-3d-and-immersive-3d
#1
Vaja Liluashvili, Selim Kalayci, Eugene Fluder, Manda Wilson, Aaron Gabow, Zeynep H Gümüs
Visualizations of biomolecular networks assist in systems-level data exploration in many cellular processes. Data generated from high-throughput experiments increasingly inform these networks, yet current tools do not adequately scale with concomitant increase in their size and complexity. We present an open source software platform, interactome-CAVE (iCAVE), for visualizing large and complex biomolecular interaction networks in 3D. Users can explore networks (i) in 3D using a desktop, (ii) in stereoscopic 3D using 3D-vision glasses and a desktop, or (iii) in immersive 3D within a CAVE environment...
August 1, 2017: GigaScience
https://www.readbyqxmd.com/read/28814034/automated-assessment-of-symptom-severity-changes-during-deep-brain-stimulation-dbs-therapy-for-parkinson-s-disease
#2
Paolo Angeles, Yen Tai, Nicola Pavese, Samuel Wilson, Ravi Vaidyanathan
Deep brain stimulation (DBS) is currently being used as a treatment for symptoms of Parkinson's disease (PD). Tracking symptom severity progression and deciding the optimal stimulation parameters for people with PD is extremely difficult. This study presents a sensor system that can quantify the three cardinal motor symptoms of PD - rigidity, bradykinesia and tremor. The first phase of this study assesses whether data recorded from the system during physical examinations can be used to correlate to clinician's severity score using supervised machine learning (ML) models...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28814013/a-third-arm-design-of-a-bypass-prosthesis-enabling-incorporation
#3
Adam W Wilson, Daniel H Blustein, Jon W Sensinger
A variety of factors affect the performance of a person using a myoelectric prosthesis, including increased control noise, reduced sensory feedback, and muscle fatigue. Many studies use able-bodied subjects to control a myoelectric prosthesis using a bypass socket in order to make comparisons to movements made with intact limbs. Depending on the goals of the study, this approach can also allow for greater subject numbers and more statistical power in the analysis of the results. As we develop assessment tools and techniques to evaluate how peripheral nerve interfaces impact prosthesis incorporation, involving normally limbed subjects in the studies becomes challenging...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813999/upper-limb-prosthetic-control-using-wearable-multichannel-mechanomyography
#4
Samuel Wilson, Ravi Vaidyanathan
In this paper we introduce a robust multi-channel wearable sensor system for capturing user intent to control robotic hands. The interface is based on a fusion of inertial measurement and mechanomyography (MMG), which measures the vibrations of muscle fibres during motion. MMG is immune to issues such as sweat, skin impedance, and the need for a reference signal that is common to electromyography (EMG). The main contributions of this work are: 1) the hardware design of a fused inertial and MMG measurement system that can be worn on the arm, 2) a unified algorithm for detection, segmentation, and classification of muscle movement corresponding to hand gestures, and 3) experiments demonstrating the real-time control of a commercial prosthetic hand (Bebionic Version 2)...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813932/quantifying-infant-physical-interactions-using-sensorized-toys-in-a-natural-play-environment
#5
Vatsala Goyal, Wilson Torres, Roshan Rai, Frances Shofer, Daniel Bogen, Phillip Bryant, Laura Prosser, Michelle J Johnson
Infants with developmental delays must be detected early in their development to minimize the progression of motor and neurological impairments. Our objective is to quantify how sensorized toys in a natural play environment can promote infant-toy physical interactions. We created a hanging elephant toy, equipped with an inertial measurement unit (IMU), a pressure transducer, and multiple feedback sensors, to be a hand-grasping toy. We used a 3 DoF robotic model with inputs from the IMU to calculate multiple kinematic metrics and an equation to calculate haptic metrics from the pressure transducer...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813907/position-and-stiffness-modulation-of-a-wrist-haptic-device-using-myoelectric-interface
#6
Chris Wilson Antuvan, Lorenzo Masia
Modulation of stiffness provides a great deal of advantage in the way humans interact with the environment, and is very important in successfully performing activities of daily living. In the context of human-machine interactions, stiffness control could provide a safer interaction, especially when dealing with unpredictable environment. In this paper we propose a user-modulated stiffness and position control for the wrist flexion/extension degree of freedom while physically coupled to a haptic device. A virtual position tracking experiment in a varying external force field is designed in order to test the performance of the control strategy with and without co-contraction techniques...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813800/the-effects-of-control-signal-noise-on-simultaneous-submovements
#7
Kathleen R Wilson, Kevin B Englehart, Jon W Sensinger
Understanding the stereotypical characteristics of human movement can better inform rehabilitation practices by providing a template of healthy and expected human motor control. Multiplicative noise is inherent in goal-directed movement, such as reaching to grasp an object. Multiplicative noise plays an important role in computational motor control models to help support phenomena such as stereotypical kinematic profiles in time-constrained and unconstrained tasks. Most tasks are not carried out along an isolated degree-of-freedom (DOF), and modelling the contribution of noise can be difficult...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813673/multipotent-basal-stem-cells-maintained-in-localized-proximal-niches-support-directed-long-ranging-epithelial-flows-in-human-prostates
#8
Mohammad Moad, Edouard Hannezo, Simon J Buczacki, Laura Wilson, Amira El-Sherif, David Sims, Robert Pickard, Nicholas A Wright, Stuart C Williamson, Doug M Turnbull, Robert W Taylor, Laura Greaves, Craig N Robson, Benjamin D Simons, Rakesh Heer
Sporadic mitochondrial DNA mutations serve as clonal marks providing access to the identity and lineage potential of stem cells within human tissues. By combining quantitative clonal mapping with 3D reconstruction of adult human prostates, we show that multipotent basal stem cells, confined to discrete niches in juxta-urethral ducts, generate bipotent basal progenitors in directed epithelial migration streams. Basal progenitors are then dispersed throughout the entire glandular network, dividing and differentiating to replenish the loss of apoptotic luminal cells...
August 15, 2017: Cell Reports
https://www.readbyqxmd.com/read/28813183/quality-of-life-in-children-with-orofacial-clefts-and-caregiver-well-being
#9
L Sischo, M Wilson-Genderson, H L Broder
Quality of life is a valid patient-reported parameter that provides an assessment of treatment need or outcomes complementary to standard clinical measures. Such patient-reported assessments are particularly salient when examining chronic conditions with prolonged treatment trajectories, such as cleft lip and palate. This critical review identifies key questions related to ongoing research on the oral health-related quality of life (OHRQoL) in children with cleft and caregiver well-being. Details of the design and results from 2 longitudinal multicenter studies are presented...
August 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28813069/atualiza%C3%A3-%C3%A3-o-da-diretriz-brasileira-de-dislipidemias-e-preven%C3%A3-%C3%A3-o-da-aterosclerose-%C3%A2-2017
#10
André Arpad Faludi, Maria Cristina de Oliveira Izar, José Francisco Kerr Saraiva, Ana Paula Marte Chacra, Henrique Tria Bianco, Abrahão Afiune, Adriana Bertolami, Alexandre C Pereira, Ana Maria Lottenberg, Andrei C Sposito, Antonio Carlos Palandri Chagas, Antonio Casella, Antônio Felipe Simão, Aristóteles Comte de Alencar, Bruno Caramelli, Carlos Costa Magalhães, Carlos Eduardo Negrão, Carlos Eduardo Dos Santos Ferreira, Carlos Scherr, Claudine Maria Alves Feio, Cristiane Kovacs, Daniel Branco de Araújo, Daniel Magnoni, Daniela Calderaro, Danielle Menosi Gualandro, Edgard Pessoa de Mello, Elizabeth Regina Giunco Alexandre, Emília Inoue Sato, Emilio Hideyuki Moriguchi, Fabiana Hanna Rached, Fábio César Dos Santos, Fernando Henpin Yue Cesena, Francisco Antonio Helfenstein Fonseca, Henrique Andrade Rodrigues da Fonseca, Hermes Toros Xavier, Isabela Cardoso Pimentel Mota, Isabela de Carlos Back Giuliano, Jaqueline Scholz Issa, Jayme Diament, João Bosco Pesquero, José Ernesto Dos Santos, José Rocha Faria, José Xavier de Melo, Juliana Tieko Kato, Kerginaldo Paulo Torres, Marcelo Chiara Bertolami, Marcelo Heitor Vieira Assad, Márcio Hiroshi Miname, Marileia Scartezini, Neusa Assumpta Forti, Otávio Rizzi Coelho, Raul Cavalcante Maranhão, Raul Dias Dos Santos, Renato Jorge Alves, Roberta Lara Cassani, Roberto Tadeu Barcellos Betti, Tales de Carvalho, Tânia Leme da Rocha Martinez, Viviane Zorzanelli Rocha Giraldez, Wilson Salgado
No abstract text is available yet for this article.
July 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28812948/age-related-resistance-in-arabidopsis-thaliana-involves-the-mads-domain-transcription-factor-short-vegetative-phase-and-direct-action-of-salicylic-acid-on-pseudomonas-syringae
#11
Daniel C Wilson, Christine J Kempthorne, Philip Carella, David K Liscombe, Robin Cameron
Arabidopsis thaliana exhibits a developmentally regulated disease-resistance response known as Age-Related Resistance (ARR), a process that requires intercellular accumulation of salicylic acid (SA), which is thought to act as an antimicrobial agent. ARR is characterized by enhanced resistance to some pathogens at the late adult-vegetative and reproductive stages. While the transition to flowering does not cause the onset of ARR, both processes involve the MADS-domain transcription factor SHORT VEGETATIVE PHASE (SVP)...
August 16, 2017: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/28812822/how-could-private-healthcare-better-contribute-to-healthcare-coverage-in-vietnam
#12
Mai Phuong Nguyen, Andrew Wilson
Private healthcare services in Vietnam are seen as a major part of the solution to the rapid increase in need and demand for healthcare services. Formally recognized over 20 years ago, the private health services coexist with public services and are available all over the country. However, the scale and size of private sector is still small compared to the public sector and public acceptance and reputation still limited. There are substantial concerns with the quality of services and the adequacy of regulation...
January 22, 2017: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/28812736/the-evolution-and-population-diversity-of-human-specific-segmental-duplications
#13
Megan Y Dennis, Lana Harshman, Bradley J Nelson, Osnat Penn, Stuart Cantsilieris, John Huddleston, Francesca Antonacci, Kelsi Penewit, Laura Denman, Archana Raja, Carl Baker, Kenneth Mark, Maika Malig, Nicolette Janke, Claudia Espinoza, Holly A F Stessman, Xander Nuttle, Kendra Hoekzema, Tina A Lindsay-Graves, Richard K Wilson, Evan E Eichler
Segmental duplications contribute to human evolution, adaptation and genomic instability but are often poorly characterized. We investigate the evolution, genetic variation and coding potential of human-specific segmental duplications (HSDs). We identify 218 HSDs based on analysis of 322 deeply sequenced archaic and contemporary hominid genomes. We sequence 550 human and nonhuman primate genomic clones to reconstruct the evolution of the largest, most complex regions with protein-coding potential (N = 80 genes from 33 gene families)...
February 17, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28812714/grand-challenges-for-the-study-of-cultural-evolution
#14
J Brewer, M Gelfand, J C Jackson, I F MacDonald, P N Peregrine, P J Richerson, P Turchin, H Whitehouse, D S Wilson
No abstract text is available yet for this article.
February 21, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28812507/advice-on-how-to-make-a-programme-successful
#15
Janine Wilson
Before taking on a degree-nurse apprentice, organisations need to consider what is involved and who should be part of the planning process.
August 16, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28811466/time-lapse-crystallography-snapshots-of-a-double-strand-break-repair-polymerase-in-action
#16
Joonas A Jamsen, William A Beard, Lars C Pedersen, David D Shock, Andrea F Moon, Juno M Krahn, Katarzyna Bebenek, Thomas A Kunkel, Samuel H Wilson
DNA polymerase (pol) μ is a DNA-dependent polymerase that incorporates nucleotides during gap-filling synthesis in the non-homologous end-joining pathway of double-strand break repair. Here we report time-lapse X-ray crystallography snapshots of catalytic events during gap-filling DNA synthesis by pol μ. Unique catalytic intermediates and active site conformational changes that underlie catalysis are uncovered, and a transient third (product) metal ion is observed in the product state. The product manganese coordinates phosphate oxygens of the inserted nucleotide and PPi...
August 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28810977/moving-beyond-accidental-leadership-a-graduate-medical-education-leadership-curriculum-needs-assessment
#17
Joshua D Hartzell, Clifton E Yu, Brian M Cohee, Michael R Nelson, Ramey L Wilson
BACKGROUND: Despite calls for greater physician leadership, few medical schools, and graduate medical education programs provide explicit training on the knowledge, skills, and attitudes necessary to be an effective physician leader. Rather, most leaders develop through what has been labeled "accidental leadership." A survey was conducted at Walter Reed to define the current status of leadership development and determine what learners and faculty perceived as key components of a leadership curriculum...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28810212/evaluation-of-bikers-against-child-abuse-baca-program-a-community-intervention-for-child-abuse-victims
#18
Dee C Ray, J P Lilly, Nancy Gallina, Paula MacIan, Brittany Wilson
Children who have experienced physical abuse benefit from a multitude of community interventions including support programs to address emotional and behavioral stability. This pilot study evaluated the services of Bikers Against Child Abuse (BACA), a community of bikers lending intervention to abused children, using a pre/post exploratory design. Participants (N=154) were children who had been referred by parents/guardians for current or past physical and/or sexual abuse. Parents/guardians of children were interviewed four times over a course of one year...
August 5, 2017: Evaluation and Program Planning
https://www.readbyqxmd.com/read/28810162/standardized-anthropological-measurement-of-postcranial-bones-using-three-dimensional-models-in-cad-software
#19
Mikaela S Reynolds, Donna M MacGregor, Mark D Barry, Nicolene Lottering, Beat Schmutz, Lance J Wilson, Matthew Meredith, Laura S Gregory
This study introduces a standardized protocol for conducting linear measurements of postcranial skeletal elements using three-dimensional (3D) models constructed from post-mortem computed tomography (PMCT) scans. Using femoral DICOM datasets, reference planes were generated and plane-to-plane measurements were conducted on 3D surface rendered models. Bicondylar length, epicondylar breadth, anterior-posterior (AP) diameter, medial-lateral (ML) diameter and cortical area at the midshaft were measured by four observers to test the measurement error variance and observer agreement of the protocol (n=6)...
July 26, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28810157/propagating-the-haze-community-and-professional-perceptions-of-cannabis-cultivation-and-the-impacts-of-prohibition
#20
Helen Beckett Wilson, Stuart Taylor, Giles Barrett, Janet Jamieson, Lauren Grindrod
BACKGROUND: Recent decades have seen substantial changes in the UK cannabis landscape, including increased domestic production, the ascendancy of stronger strains (namely 'skunk') and the drug's reclassification under the 1971 Misuse of Drugs Act. Resultantly, cannabis retains significance in the consciousness, priorities and policy agendas of communities, drug services and criminal justice agencies. METHODS: This paper presents an empirical study, which examined both perceptions and impacts of cannabis cultivation and its control within a North-West English borough...
August 12, 2017: International Journal on Drug Policy
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