Qianqi Huang, Jingpu Wu, Nhat Le, Yiqing Shen, Pengfei Guo, Karisa C Schreck, David Kamson, Lindsay Blair, Hye Young Heo, Xu Li, Wenbo Li, Haris L Sair, Jaishri O Blakeley, John Laterra, Matthias Holdhoff, Stuart A Grossman, Debraj Mukherjee, Chetan Bettegowda, Peter van Zijl, Jinyuan Zhou, Shanshan Jiang
New or enlarged lesions in malignant gliomas after surgery and chemoradiation can be associated with tumor recurrence or treatment effect. Due to similar radiographic characteristics, conventional-and even some advanced MRI techniques-are limited in distinguishing these two pathologies. Amide proton transfer-weighted (APTw) MRI, a protein-based molecular imaging technique that does not require the administration of any exogenous contrast agent, was recently introduced into the clinical setting. In this study, we evaluated and compared the diagnostic performances of APTw MRI with several non-contrast-enhanced MRI sequences, such as diffusion-weighted imaging, susceptibility-weighted imaging, and pseudo-continuous arterial spin labeling...
June 13, 2023: Magnetic Resonance Imaging