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https://www.readbyqxmd.com/read/29929552/anterior-hypopituitarism-in-a-patient-with-amyloidosis-secondary-to-crohn-s-disease-a-case-report
#1
Natacha Verbeke, Nathalie Pirson, Arnaud Devresse, Raluca Furnica, Thierry Duprez, Dominique Maiter
BACKGROUND: Amyloid infiltration of endocrine glands has been reported, mostly in the thyroid, pancreas, adrenals, and testes, but affected patients do not frequently exhibit overt endocrine insufficiency. Here we report the case of a patient with complete anterior hypopituitarism probably due to a known systemic amyloidosis. CASE PRESENTATION: Our male Caucasian patient was diagnosed with Crohn's disease at the age of 22 years. At the age of 37, he developed secondary renal amyloidosis, which resulted in end-stage renal failure...
June 22, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29928477/lymph-node-density-in-papillary-thyroid-carcinoma-is-a-prognostic-factor-after-adjusting-for-pathological-stage
#2
Hidenori Suzuki, Yusuke Koide, Nobuhiro Hanai, Daisuke Nishikawa, Shintaro Beppu, Shinji Mikami, Yasuhisa Hasegawa
We investigated the possible association between the lymph node density and survival outcomes in differentiated papillary thyroid carcinoma, and examined whether the lymph node density was a predictor in a multivariate analysis adjusted for the pathological stage in the eighth edition of the Union for International Cancer Control Tumor-Node Metastasis Classification of Malignant Tumors. A total of 543 patients with papillary thyroid carcinoma were enrolled. We performed restaging according to the eighth edition...
June 1, 2018: Oncotarget
https://www.readbyqxmd.com/read/29927436/-clinical-morphological-and-prognostic-features-of-papillary-thyroid-carcinoma-with-different-braf-mutational-status-assessed-by-immunohistochemistry
#3
A V Sidorin, A Yu Abrosimov, T I Rogunovich, P O Rumyantsev, K S Nizhegorodova, P A Isaev, A P Shinkarkina, S Yamasita, V A Saenko
The somatic mutation in BRAFT1799A (BRAFV600E ), the data on the prognostic role of which are contradictory, is one of the most common molecular genetic abnormalities in the cells of papillary thyroid carcinoma (PTC). OBJECTIVE: To investigate the association of the immunoexpression of mutant BRAF in PTC with different morphological characteristics and long-term treatment results in patients. MATERIAL AND METHODS: Information on inpatients with PTC was obtained from the database of the Pathology Department, A...
2018: Arkhiv Patologii
https://www.readbyqxmd.com/read/29925379/multi-tissue-and-multi-scale-approach-for-nuclei-segmentation-in-h-e-stained-images
#4
Massimo Salvi, Filippo Molinari
BACKGROUND: Accurate nuclei detection and segmentation in histological images is essential for many clinical purposes. While manual annotations are time-consuming and operator-dependent, full automated segmentation remains a challenging task due to the high variability of cells intensity, size and morphology. Most of the proposed algorithms for the automated segmentation of nuclei were designed for specific organ or tissues. RESULTS: The aim of this study was to develop and validate a fully multiscale method, named MANA (Multiscale Adaptive Nuclei Analysis), for nuclei segmentation in different tissues and magnifications...
June 20, 2018: Biomedical Engineering Online
https://www.readbyqxmd.com/read/29921174/the-prognostic-impact-of-tumor-size-in-papillary-thyroid-carcinoma-is-modified-by-age
#5
Bryan Minh Tran, David James Roshan, Earl Abraham, Laura Y Wang, Natalia Garibotto, James Wykes, Peter Campbell, Ardalan Ebrahimi
BACKGROUND: Although the importance of tumor size in papillary thyroid cancer (PTC) is well established, there is no research to investigate whether age modifies the impact of tumor size, and conflicting evidence regarding optimal size thresholds for prognostic discrimination. We aimed to verify that tumor size is an independent prognostic factor in PTC, to investigate the impact of patient age, and to identify optimal size cut-offs for risk stratification using objective measures of model performance...
June 19, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29916728/quantitative-assessment-of-the-flow-distribution-in-the-branches-of-the-external-carotid-by-non-injected-flow-mri
#6
Jérémie Bettoni, Gwénaël Pagé, Anne-Virginie Salsac, Jean-Marc Constans, Sylvie Testelin, Bernard Devauchelle, Olivier Balédent, Stéphanie Dakpé
Owing to the lack of databases of blood flow distributions in the external carotid branches, surgeons currently rely on per-operative imaging and on their experience to choose the recipient vessels for microsurgical facial reconstructions. But, thanks to three-dimensional phase contrast angiography (PCA) and kinematic CINE phase contrast (PC) sequences, MRI technologies have the potential to provide quantitative anatomical and hemodynamic information without injection of contrast agent. Having developed and optimized PC-MRI sequences for the small facial vessels, our objective was to investigate the haemodynamic and blood flow distribution in the external carotid branches...
June 19, 2018: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/29914908/prevalence-and-outcomes-of-incidental-imaging-findings-umbrella-review
#7
Jack W O'Sullivan, Tim Muntinga, Sam Grigg, John P A Ioannidis
OBJECTIVE: To provide an overview of the evidence on prevalence and outcomes of incidental imaging findings. DESIGN: Umbrella review of systematic reviews. DATA SOURCES: Searches of MEDLINE, EMBASE up to August 2017; screening of references in included papers. ELIGIBILITY CRITERIA: Criteria included systematic reviews and meta-analyses of observational studies that gave a prevalence of incidental abnormalities ("incidentalomas")...
June 18, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29914872/metformin-and-jq1-synergistically-inhibit-obesity-activated-thyroid-cancer
#8
Sunmi Park, Mark Willingham, Jun Qi, Sheue-Yann Cheng
Compelling epidemiological evidence shows a strong positive correlation of obesity with thyroid cancer. In vivo studies have provided molecular evidence that high-fat-diet-induced obesity promotes thyroid cancer progression by aberrantly activating leptin-JAK2-STAT3 signaling in a mouse model of thyroid cancer (ThrbPV/PVPten+/- mice). The ThrbPV/PVPten+/- mouse expresses a dominantly negative thyroid hormone receptor β (denoted as PV) and a deletion of one single allele of the Pten gene. The ThrbPV/PVPten+/- mouse spontaneously develops follicular thyroid cancer, which allows its use as a preclinical mouse model to test potential therapeutics...
June 18, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29912343/impact-on-testicular-function-of-a-single-ablative-activity-of-3-7-gbq-radioactive-iodine-for-differentiated-thyroid-carcinoma
#9
N Bourcigaux, C Rubino, I Berthaud, M E Toubert, B Donadille, L Leenhardt, I Petrot-Keller, S Brailly-Tabard, J Fromigué, F de Vathaire, T Simon, J P Siffroi, M Schlumberger, P Bouchard, S Christin-Maitre
STUDY QUESTION: What are the consequences of radioactive iodine (RAI) therapy for testicular function? SUMMARY ANSWER: A single activity of 3.7 GBq RAI for differentiated thyroid carcinoma (DTC) treatment in young men transiently altered Sertoli cell function and induced sperm chromosomal abnormalities. WHAT IS KNOWN ALREADY: Few studies, mainly retrospective, have reported the potential impacts of RAI on endocrine and exocrine testicular function...
June 15, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29911397/transient-hyperthyroidism-induced-by-thyroid-ultrasound
#10
Rajini K Yatavelli, Steven N Levine
OBJECTIVES: Transient hyperthyroidism has been documented following surgical manipulation or direct trauma to the normal thyroid gland. This has best been studied in patients following parathyroidectomy and also reported following trauma to the neck, strangulation, and vigorous palpation of the thyroid gland. It has not previously been reported following a thyroid ultrasound. METHODS: We report the case of a 58-year-old euthyroid woman with a large nontoxic multinodular goiter who developed transient hyperthyroidism following an ultrasound of the thyroid gland...
June 1, 2018: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29911045/congenital-hypothyroidism-screening-in-term-neonates-using-umbilical-cord-blood-tsh-values
#11
Ravi Bhatia, Dinesh Rajwaniya
Congenital hypothyroidism remains one of the most common preventable causes of mental retardation among children. Screening for congenital hypothyroidism remains one of the most cost-effective tools to prevent mental retardation in the population. Umbilical cord blood thyroid-stimulating hormone (TSH) levels remain an attractive and a practical step for screening for congenital hypothyroidism. The aims of this study were as follows: (1) to find normative values of cord blood TSH for the study group and (2) to use cord blood TSH levels as a marker for screening of congenital hypothyroidism...
March 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29910553/thyrotoxic-hypokalemic-periodic-paralysis
#12
Satyendra Kumar Sonkar, Satish Kumar, Neeraj Kumar Singh
Hypokalemia is a serious and life-threatening clinical condition. We present a case of a 45-year-old male, with known hyperthyroidism presenting with profound tremor, irritability, quadriparesis, and labored breathing since morning, on the day of admission. Arterial blood gas analysis showed severe hypokalemia. Patient's vital was stabilized and patient's oxygen saturation was maintained on oxygen inhalation. Intravenous potassium chloride infusion was administered with regular monitoring of vitals and electrolytes...
May 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29910183/rhabdomyolysis-in-a-patient-complicated-with-hypopituitarism-and-multiple-organ-dysfunction-syndrome-and-the-literature-review
#13
Chuan Zhou, Shichao Lai, Yong Xie, Shu Zhang, Yiping Lu
INTRODUCTION: Muscular symptoms, including stiffness, myalgia, cramps, and fatigue, are present in the majority of the patients with hypopituitarism, adrenal insufficiency and hypothyroidism, but rhabdomyolysis, the rapid breakdown of skeletal muscle, is a rare manifestation. In most patients who develop rhabdomyolysis, precipitating factors, such as strenuous exercise or use of lipid-lowering drugs, can be identified. CASE REPORT: We report the case of a 23-year-old male with primary hypopituitarism who developed acute renal impairment (AKI) with rhabdomyolysis after strenuous physical activity (push-ups)...
June 7, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29909600/patients-knowledge-about-the-outcomes-of-thyroid-biopsy-a-patient-survey
#14
Naykky Singh Ospina, Ana Castaneda-Guarderas, Russell Ward, Juan P Brito, Spyridoula Maraka, Claudia Zeballos Palacios, Kathleen J Yost, Diana S Dean, Victor M Montori
PURPOSE: Fine-needle aspiration biopsy of the thyroid is an increasingly common outpatient procedure. Patients are counseled about the indications and risks of this procedure and informed consent is obtained. We aimed to assess the extent to which patients acquired necessary knowledge during this process. METHODS: Survey study conducted in a thyroid nodule clinic at a referral center. Adult patients who had just undergone a thyroid biopsy were asked to complete a survey, including eight questions regarding the indications and potential outcomes of thyroid biopsy...
June 16, 2018: Endocrine
https://www.readbyqxmd.com/read/29909599/survival-of-aggressive-variants-of-papillary-thyroid-carcinoma-in-patients-under-55-years-old-a-seer-population-based-retrospective-analysis
#15
Jianhua Feng, Fei Shen, Wensong Cai, Xiaoxiong Gan, Xingyan Deng, Bo Xu
BACKGROUND: Patients younger than 55 years of age with papillary thyroid carcinoma (PTC) have excellent survival. Diffuse sclerosing variant (DSV) and tall cell variant (TCV) of PTC are associated with aggressiveness; the survival of patients <55 years of age with these variants is still unclear. We aim to investigate the clinicopathological features and survival of these variants in the age group <55 years. METHODS: All adult patients (<55 years old) with DSV, TCV and conventional PTC (CPTC) came from the Surveillance, Epidemiology, and End Results program (1988-2013)...
June 16, 2018: Endocrine
https://www.readbyqxmd.com/read/29908978/feasibility-of-intravoxel-incoherent-motion-for-differentiating-benign-and-malignant-thyroid-nodules
#16
Hui Tan, Jun Chen, Yi Ling Zhao, Jin Huan Liu, Liang Zhang, Chang Sheng Liu, Dongjie Huang
RATIONALE AND OBJECTIVES: This study aimed to preliminarily investigate the feasibility of intravoxel incoherent motion (IVIM) theory in the differential diagnosis of benign and malignant thyroid nodules. MATERIALS AND METHODS: Forty-five patients with 56 confirmed thyroid nodules underwent preoperative routine magnetic resonance imaging and IVIM diffusion-weighted imaging. The histopathologic diagnosis was confirmed by surgery. Apparent diffusion coefficient (ADC), perfusion fraction f, diffusivity D, and pseudo-diffusivity D* were quantified...
June 13, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29908087/scotostimulation-of-reproductive-neural-pathways-and-gonadal-maturation-are-not-correlated-with-hypothalamic-expression-of-deiodinases-in-subtropical-spotted-munia
#17
Ila Mishra, Neha Agarwal, Sangeeta Rani, Vinod Kumar
Circannual rhythm regulates annual timing of reproduction in spotted munia, with sex-differences in its relationship with the external photoperiod environment. Interestingly, munia show an atypical photosensitivity and exhibit gonadal maturation when acutely exposed to an unnatural short photoperiod (e.g. 3 h light per day; i.e. a long scotoperiod). The proximate mechanisms regulating scotoperiod-induced hypothalamus-pituitary-gonadal (HPG) activation are unclear. Since thyroid hormone signalling plays a central role in photoperiodic induction, we hypothesized the involvement of similar mechanism, i...
June 16, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29905933/the-classification-of-pediatric-and-young-adult-renal-cell-carcinomas-registered-on-the-children-s-oncology-group-cog-protocol-aren03b2-after-focused-genetic-testing
#18
Mariana M Cajaiba, Lisa M Dyer, James I Geller, Lawrence J Jennings, David George, Dawn Kirschmann, Stephen M Rohan, Nicholas G Cost, Geetika Khanna, Elizabeth A Mullen, Jeffrey S Dome, Conrad V Fernandez, Elizabeth J Perlman
BACKGROUND: Renal cell carcinomas (RCCs) are rare in young patients. Knowledge of their pathologic and molecular spectrum remains limited, and no prospective studies have been performed to date in this population. This study analyzes patients diagnosed with RCC who were prospectively enrolled in the AREN03B2 Children's Oncology Group (COG). The objective was to classify these tumors with the aid of focused genetic testing and to characterize their features. METHODS: All tumors registered as RCC by central review were retrospectively re-reviewed and underwent additional ancillary studies...
June 15, 2018: Cancer
https://www.readbyqxmd.com/read/29905638/the-columbia-thyroid-eye-disease-compressive-optic-neuropathy-formula
#19
Alison B Callahan, Ashley A Campbell, Susel Oropesa, Aryeh Baraban, Michael Kazim
PURPOSE: Diagnosing thyroid eye disease-compressive optic neuropathy (TED-CON) is challenging, particularly in cases lacking a relative afferent pupillary defect. Large case series of TED-CON patients and accessible diagnostic tools are lacking in the current literature. This study aims to create a mathematical formula that accurately predicts the presence or absence of CON based on the most salient clinical measures of optic neuropathy. METHODS: A retrospective case series compares 108 patients (216 orbits) with either unilateral or bilateral TED-CON and 41 age-matched patients (82 orbits) with noncompressive TED...
June 13, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29905543/importance-of-isolated-gestational-hypothyroxinemia-in-the-development-of-obstetric-and-somatic-pathologies
#20
N Morchiladze, B Tkeshelashvili, T Gagua, D Gagua
The isolated hypothyroxinemia of pregnancy (IHP) has gained specific attention in the specialized literature during the recent years as the possible factor impeding the intellectual development of fetus and increasing the risk of complications related with pregnancy, delivery and perinatal period. Aim of the study was to define the importance of isolated hypothyroxinemia in the development of obstetric and somatic pathologies in outpatient population of pregnant females. The study of prospective design was performed at the base of "David Gagua Clinic" Ltd...
May 2018: Georgian Medical News
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