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Thyroid testing

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https://www.readbyqxmd.com/read/29222896/serum-vitamin-b-12-in-children-presenting-with-vasovagal-syncope
#1
Ayhan Pektas, Resit Koken, Halit Bugra Koca
BACKGROUND AND OBJECTIVES: The present study aims to determine the serum vitamin B-12 in children presenting with vasovagal syncope. METHODS AND STUDY DESIGN: This is a prospective review of 160 children presenting with vasovagal syncope. Subgroup analysis was done based on the results of head up tilt test. RESULTS: Head up tilt test gave positive results in 80 children and yielded negative results in the remaining 80 children. The tilt test positive children had significantly lower thyroid stimulating hormone concentrations (p=0...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29221487/clinical-laboratory-verification-of-thyroglobulin-concentrations-in-the-presence-of-autoantibodies-to-thyroglobulin-comparison-of-eia-radioimmunoassay-and-lc-ms-ms-measurements-in-an-urban-hospital
#2
Sarah E Wheeler, Li Liu, Harry C Blair, Richard Sivak, Nancy Longo, Jeffery Tischler, Kathryn Mulvey, Octavia M Peck Palmer
OBJECTIVE: Thyroglobulin (Tg) measurements assess recurrence in post-thyroidectomy thyroid cancer patients. Tg measurements by enzyme immunoassays (EIA) can be falsely elevated by interference from Tg autoantibodies (TgAb). Radioimmunoassay (RIA) is less susceptible to TgAb interference and has been the standard-of-care test for TgAb positive patients. Recently developed liquid chromatography tandem mass spectrometry (LC-MS/MS) methods may eliminate TgAb interference. We assessed the performance of Tg measurements by EIA, RIA and LC-MS/MS to evaluate TgAb interference differences...
December 8, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29221192/tumor-suppressive-function-of-unc5d-in-papillary-thyroid-cancer
#3
Man-Man Zhang, Feng Sun, Bing Cui, Le-Le Zhang, Ya Fang, Yan Li, Rui-Jia Zhang, Xiao-Ping Ye, Yu-Ru Ma, Bing Han, Huai-Dong Song
Background: Studies have shown an association of the UNC5D gene with kidney and bladder cancer and neuroblastoma. We investigated whether UNC5D acts as a tumor suppressor in papillary thyroid carcinoma (PTC). Methods: Primary PTC tumors and matched normal thyroid tissues were obtained from 112 patients to detect UNC5D mRNA by real-time PCR. Genomic DNA sequencing was performed to detect BRAF mutation in PTC tumors. The association between UNC5D expression and clinicopathological data from PTC patients was reviewed retrospectively...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29220528/maternal-thyroid-function-in-early-pregnancy-and-neuropsychological-performance-of-the-child-at-5-years-of-age
#4
Stine Linding Andersen, Stig Andersen, Zeyan Liew, Peter Vestergaard, Jørn Olsen
Context: Abnormal maternal thyroid function in pregnancy may impair fetal brain development, but more evidence is needed to refine and corroborate the hypothesis. Objective: To estimate the association between maternal thyroid function in early pregnancy and neuropsychological performance of the child at 5 years of age. Design: Follow-up study. Participants: A cohort of 1,153 women and their children sampled from the Danish National Birth Cohort...
December 6, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29219024/excess-maternal-thyroxine-alters-the-proliferative-activity-and-angiogenic-profile-of-growth-cartilage-of-rats-at-birth-and-weaning
#5
Lorena Gabriela Rocha Ribeiro, Juneo Freitas Silva, Natália de Melo Ocarino, Cíntia Almeida de Souza, Eliane Gonçalves de Melo, Rogéria Serakides
Objective The aim of this study was to unravel the mechanisms by which thyroxine affects skeletal growth by evaluating proliferative activity and angiogenic profile of growth cartilage of neonatal and weanling rats. Methods Sixteen adult Wistar rats were equally divided into 2 groups: control and treated with thyroxine during pregnancy and lactation. The weight, measurement of plasma free T4 and thyroids, femurs' histomorphometric analysis, and proliferative activity and angiogenic profile by immunohistochemical or real-time reverse transcriptase-polymerase chain reaction in growth cartilage was performed...
January 2018: Cartilage
https://www.readbyqxmd.com/read/29218595/quantitative-testing-of-prescriber-knowledge-regarding-the-risks-and-safe-use-of-albiglutide
#6
Carol Koro, Janet Pientka, Veronica Bainbridge, Natalie O'Donnell, Monika Stender, Annette Stemhagen
BACKGROUND: The risk of pancreatitis and potential risk of medullary thyroid carcinoma associated with glucagon-like peptide-1 receptor agonists prompted the US Food and Drug Administration to require a Risk Evaluation and Mitigation Strategy for albiglutide, including education for prescribers and subsequent assessment of their knowledge of the risks and safe use of albiglutide via a quantitative survey. OBJECTIVE: The objective of this study was to assess prescribers' knowledge of the risks related to medullary thyroid carcinoma, pancreatitis, and the appropriate patient population for albiglutide...
December 7, 2017: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/29218227/lessons-learnt-from-a-case-of-missed-central-hypothyroidism
#7
Tessa Glyn, Beverley Harris, Kate Allen
We present the case of a 57-year-old lady who had a delayed diagnosis of central hypothyroidism on a background of Grave's thyrotoxicosis and a partial thyroidectomy. During the twenty years following her partial thyroidectomy, the patient developed a constellation of symptoms and new diagnoses, which were investigated by numerous specialists from various fields, namely rheumatology, renal and respiratory. She developed significantly impaired renal function and raised creatine kinase (CK). She was also referred to a tertiary neurology service for investigation of myositis, which resulted in inconclusive muscle biopsies...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29215302/treatment-of-goiter-with-traditional-chinese-medicine-regimen-xing-qi-hua-ying-tang-a-clinical-study-on-72-patients-with-multinodular-and-diffuse-goiter
#8
Ming-Li Yang, Bo Lu
OBJECTIVE: The present work aimed to further explore the therapeutic potential of Xing Qi Hua Ying Tang (XQHYT) by conducting a systemic clinical study in patients with goiter. DESIGN: Seventy-two patients with either multinodular or diffuse goiter were enrolled and randomly assigned into treatment group receiving XQHYT (n = 36) and control group receiving Hai Zao Yu Hu Tang (n = 36). LOCATION: Traditional Chinese Medicine Hospital of Shanxi...
December 7, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/29214440/massarray-based-simultaneous-detection-of-hotspot-somatic-mutations-and-recurrent-fusion-genes-in-papillary-thyroid-carcinoma-the-ptc-ma-assay
#9
Chiara Pesenti, Marina Muzza, Carla Colombo, Maria Carla Proverbio, Claudia Farè, Stefano Ferrero, Monica Miozzo, Laura Fugazzola, Silvia Tabano
PURPOSE: We exploited the MassARRAY (MA) genotyping platform to develop the "PTC-MA assay", which allows the simultaneous detection of 13 hotspot mutations, in the BRAF, KRAS, NRAS, HRAS, TERT, AKT1, PIK3CA, and EIF1AX genes, and six recurrent genetic rearrangements, involving the RET and TRK genes in papillary thyroid cancer (PTC). METHODS: The assay was developed using DNA and cDNA from 12 frozen and 11 formalin-fixed paraffin embedded samples from 23 PTC cases, together with positive and negative controls...
December 6, 2017: Endocrine
https://www.readbyqxmd.com/read/29209734/effects-of-hypothyroidism-on-serotonin-1a-receptors-in-the-rat-brain
#10
Jae-Hoon Lee, Minkyung Lee, Ji-Ae Park, Young Hoon Ryu, Kyo Chul Lee, Kyeong Min Kim, Jae Yong Choi
PURPOSE: We investigated the effects of hypothyroidism on serotonin 1A receptors in the rat brain in vivo. METHODS: Five surgically thyroidectomized male Sprague-Dawley (SD) rats and five hypophysectomized SD rats were used as animal models of hypothyroidism; the same number of sham-operated SD rats served as age-matched controls. After hypothyroidism was confirmed by thyroid function tests, serotonin positron emission tomography (PET) was performed for 120 min...
December 5, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/29209552/corrigendum-to-challenges-in-interpretation-of-thyroid-function-tests-in-pregnant-women-with-autoimmune-thyroid-disease
#11
Ulla Feldt-Rasmussen, Sofie Bliddal, Åse Krogh Rasmussen, Malene Boas, Linda Hilsted, Katharina Main
[This corrects the article DOI: 10.4061/2011/598712.].
2017: Journal of Thyroid Research
https://www.readbyqxmd.com/read/29208878/study-of-thyroid-disorders-among-type-2-diabetic-patients-attending-a-tertiary-care-hospital
#12
N Z Khan, M A Muttalib, G S Sultana, F A Mishu, A Nesa
Type 2 diabetes mellitus (T2DM) and thyroid disorders (TD) are the two most common endocrine disorders in clinical practice. Unrecognized thyroid disorders may adversely affect the metabolic control and add more risk to an already predisposing type 2 diabetes mellitus. The objective of the study is to find out the percentage of hypothyroidism and hyperthyroidism in patients with type 2 diabetes mellitus and non diabetic subjects. This cross-sectional study was conducted in the department of Biochemistry and outpatient Department of Endocrinology, BIRDEM General Hospital, Dhaka, Bangladesh from July 2014 to June 2015...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29207397/relationship-of-serum-fetuin-a-with-metabolic-and-clinical-parameters-in-german-children-and-adolescents-with-type-1-diabetes
#13
Christina Reinauer, Thomas Reinehr, Christina Baechle, Beate Karges, Julia Seyfarth, Katharina Foertsch, Martin Schebek, Joachim Woelfle, Michael Roden, Reinhard W Holl, Joachim Rosenbauer, Thomas Meissner
BACKGROUND AND AIM: The hepatokine fetuin A is upregulated in the metabolic syndrome and in type 2 diabetes (T2D), while its role in adolescent type 1 diabetes (T1D) is unclear. We assessed the relationship between circulating fetuin A levels and metabolic control, comorbidities, and complications in adolescent T1D patients. METHODS: We studied the relationship between serum fetuin A and clinical diabetes-related data from the DPV registry (Diabetes-Pa-tienten-Verlaufsdokumentation) in 172 adolescent T1D patients with early-onset (<5 years) long-standing (>10 years) T1D...
December 5, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29205988/pericardial-fluid-assessment-and-examination
#14
Anu Turpeinen, Marja Hedman
Pericardial fluid is a common finding on echocardiography. Less than 10 mm of fluid on ultrasound scan is not necessarily associated with any significant illness. Clinical examination, blood count, renal and liver enzymes and thyroid function tests as well as inflammatory marker tests are often adequate for a patient who is in good health. A significant amount of fluid requires further investigations, especially in a symptomatic patient. Cancers, infections and various systemic diseases are the most common causes of prominent effusion...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29205379/in-vivo-measurement-of-swallowing-by-monitoring-thyroid-cartilage-movement-in-healthy-subjects-using-thickened-liquid-samples-and-its-comparison-with-sensory-evaluation
#15
Takahiro Funami, Shingo Matsuyama, Akira Ikegami, Makoto Nakauma, Kazuhiro Hori, Takahiro Ono
This research aimed to investigate the relationship between in vivo measurement of swallowing and sensory evaluation using thickened liquids as model foods. Healthy subjects (8 male and average 29.6-year old) participated in both tests, in which the subjects were asked to swallow the whole amount of sample (10 ml) at one time. In vivo measurement monitored thyroid cartilage movement during swallowing using a bendable pressure sensor synchronously with suprahyoid electromyography, whereas sensory evaluation measured perceived cohesiveness and adhesiveness on a visual analogue scale...
December 2017: Journal of Texture Studies
https://www.readbyqxmd.com/read/29204277/cytomegalovirus-mononucleosis-induced-thyroiditis-in-an-immunocompetent-patient
#16
V Larouche, M Tamilia
Enteroviruses, including coxsackieviruses and Echovirus, are well known pathogens responsible for the development of thyroiditis. We describe the case of a 49-year-old woman with no personal or family history of thyroid disease who presented to the emergency room with a two-week history of daily fevers up to 39°C, a sore throat, occasional palpitations and diaphoresis, decreased appetite and an unintentional 10 kg weight loss over the same time course Physical examination revealed mild tachycardia, an intention tremor and a normal-sized, nontender thyroid gland without palpable nodules...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29200250/intraoperative-calcitonin-stimulation-testing-in-the-surgical-treatment-of-c-cell-disease
#17
(no author information available yet)
OBJECTIVE: The prognosis of medullary thyroid carcinoma (MTC), derived from parafollicular C-cells, depends on the completeness of the initial surgical excision. The C-cells produce calcitonin, a peptide hormone used as a biochemical and immunohistochemical tumor marker. The aim of the study was to evaluate an individualized approach to patients with C-cell disease, i.e. MTC and C-cell hyperplasia (CCH), using the intraoperative calcitonin testing-assisted surgical strategy as a predictor of the final outcome...
November 4, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/29198444/endocrine-and-metabolic-assessment-in-adults-with-langerhans-cell-histiocytosis
#18
L Montefusco, S Harari, D Elia, A Rossi, C Specchia, O Torre, G Adda, M Arosio
CONTEXT: Diabetes insipidus (DI) is one of most common complications of Langerhans cell histiocytosis (LCH) but prevalence of anterior pituitary deficiencies and metabolic alterations have not been clearly defined yet. OBJECTIVES: Evaluate prevalence of endocrine and metabolic manifestations in a cohort of patients affected by Pulmonary LCH. METHODS: Observational cross-sectional study on 18 adults (7 M/11 F, 42±12years) studied for complete basal and dynamic endocrine lab tests and glucose metabolism...
November 29, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29197967/effects-of-nutraceuticals-on-anaplastic-thyroid-cancer-cells
#19
Lorenzo Allegri, Francesca Rosignolo, Catia Mio, Sebastiano Filetti, Federica Baldan, Giuseppe Damante
PURPOSE: The anaplastic thyroid carcinoma (ATC) is the most aggressive thyroid cancer with a high mortality rate. Since nutraceuticals may exert beneficial effects on tumor biology, here, effects of four of these compounds [resveratrol, genistein, curcumin and epigallocatechin-3-gallate (EGCG)] on ATC cell lines were investigated. METHODS: Two ATC-derived cell lines were used: SW1736 and 8505C. Cell viability and in vitro aggressiveness was tested by MTT and soft agar assays...
December 2, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29191500/3t-non-injected-phase-contrast-mri-sequences-for-the-mapping-of-the-external-carotid-branches-in%C3%A2-vivo-radio-anatomical-pilot-study-for-feasibility-analysis
#20
Jérémie Bettoni, Gwénaël Pagé, Anne-Virginie Salsac, Jean-Marc Constans, Sylvie Testelin, Bernard Devauchelle, Olivier Balédent, Stéphanie Dakpé
An essential stage in head and neck microsurgical reconstruction is the choice of recipient vessels. To make relevant choices, surgeons must rely on accurate imaging techniques. The objective of the study was to examine the feasibility of Phase-Contrast sequences to conduct the pre-operative tests without injection and provide precise radio-anatomical data over the entire vessel region. The challenges were the large velocity range, the lack of contrast, and the large spatial resolution needed to image vessels below 5 mm in diameter...
October 16, 2017: Journal of Cranio-maxillo-facial Surgery
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