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https://www.readbyqxmd.com/read/28091779/early-and-late-outcomes-after-surgical-management-of-congenital-vascular-rings
#1
Katrien François, Joseph Panzer, Katya De Groote, Kristof Vandekerckhove, Daniel De Wolf, Hans De Wilde, Fabienne Marchau, Wim De Caluwe, Abraham Benatar, Thierry Bové
: Persistent respiratory or feeding problems in children may be associated with a congenital vascular ring. Surgical management is fairly standardized, but long-term outcomes are not well described. This study aims to investigate clinical presentation, surgical treatment, and risk factors for early mortality and late outcome. Our database revealed 62 surgically treated vascular ring patients between 1993 and 2014. Double aortic arch was the most common diagnosis (53%). Median age at operation was 1 year...
January 13, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28090467/early-infant-feeding-practices-may-influence-the-onset-of-symptomatic-celiac-disease
#2
Shailja Vajpayee, Shiv Dayal Sharma, Rajkumar Gupta, Alok Goyal, Aakash Sharma
PURPOSE: To study whether breastfeeding and breastfeeding status during gluten introduction influences the age at diagnosis of celiac disease (CD). In addition to study, whether the timing of gluten introduction influences the age at diagnosis of CD. METHODS: It was a hospital based observational study. Total 198 patients diagnosed with CD as per modified European Society of Pediatric Gastroenterology, Hepatology and Nutrition (2012) criteria, aged between 6 months to 6 years were included...
December 2016: Pediatric Gastroenterology, Hepatology & Nutrition
https://www.readbyqxmd.com/read/28089707/understanding-infant-eating-behaviour-lessons-learned-from-observation
#3
REVIEW
Marion M Hetherington
Observations of human infants during feeding presents a rich source of data to identify the ways in which hunger, appetite and satiety are communicated in early life. Infants signal appetite through their interest or disinterest in food using a series of communication cues from rapid and transient facial expressions to subtle or potent gestures and bodily movements through to vocalisations and eventually speech. Even in the first days of life facial expressions in response to basic tastes are clearly demonstrated and shared between human infants, other primates and the rat...
January 12, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28089471/infantile-haemangioma
#4
REVIEW
Christine Léauté-Labrèze, John I Harper, Peter H Hoeger
With a prevalence of 4·5%, infantile haemangiomas are the most common benign tumours of infancy, arising in the first few weeks of life and exhibiting a characteristic sequence of growth and spontaneous involution. Most infantile haemangiomas do not require therapy. However, to identify at-risk haemangiomas, close follow-up is crucial in the first weeks of life; 80% of all haemangiomas reach their final size by 3 months of age. The main indications for treatment are life-threatening infantile haemangioma (causing heart failure or respiratory distress), tumours posing functional risks (eg, visual obstruction, amblyopia, or feeding difficulties), ulceration, and severe anatomic distortion, especially on the face...
January 12, 2017: Lancet
https://www.readbyqxmd.com/read/28088407/far-off-and-close-up-dry-matter-intake-modulate-indicators-of-immunometabolic-adaptations-to-lactation-in-subcutaneous-adipose-tissue-of-pasture-based-transition-dairy-cows
#5
M Vailati-Riboni, G Farina, F Batistel, A Heiser, M D Mitchell, M A Crookenden, C G Walker, J K Kay, S Meier, J R Roche, J J Loor
The common practice of increasing dietary energy density during the close-up dry period (last ∼3 wk prepartum) has been recently associated with a higher incidence of metabolic disorders after calving. Despite these reports, over-feeding of metabolizable energy (ME) during the far-off, nonlactating period is a common management policy aimed at achieving optimum calving body condition score (BCS) in pasture-based systems, as cows are generally thinner than total mixed ration cows at the end of lactation. Our hypothesis was that both far-off and close-up overfeeding influence the peripartum adipose tissue changes associated with energy balance and inflammatory state...
January 11, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28088215/non-associative-versus-associative-learning-by-foraging-predatory-mites
#6
Peter Schausberger, Stefan Peneder
BACKGROUND: Learning processes can be broadly categorized into associative and non-associative. Associative learning occurs through the pairing of two previously unrelated stimuli, whereas non-associative learning occurs in response to a single stimulus. How these two principal processes compare in the same learning task and how they contribute to the overall behavioural changes brought about by experience is poorly understood. We tackled this issue by scrutinizing associative and non-associative learning of prey, Western flower thrips Frankliniella occidentalis, by the predatory mite, Neoseiulus californicus...
January 14, 2017: BMC Ecology
https://www.readbyqxmd.com/read/28088203/a-3-arm-randomised-controlled-trial-of-communicating-healthy-beginnings-advice-by-telephone-chat-to-mothers-with-infants-to-prevent-childhood-obesity
#7
Li Ming Wen, Chris Rissel, Louise A Baur, Alison J Hayes, Huilan Xu, Anna Whelan, Myna Hua, Miranda Shaw, Philayrath Phongsavan
BACKGROUND: With an increasing prevalence of obesity in young children globally, there is an urgent need for the development of effective early interventions. A previous Healthy Beginnings Trial using a nurse-led home visiting program has demonstrated that providing mothers with evidence-based advice can improve maternal practice regarding obesity prevention, and can reduce Body Mass Index (BMI) in the first few years of life. However, the costs for scale-up of home visiting limit its population reach...
January 14, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28086874/new-developments-in-anti-malarial-target-candidate-and-product-profiles
#8
REVIEW
Jeremy N Burrows, Stephan Duparc, Winston E Gutteridge, Rob Hooft van Huijsduijnen, Wiweka Kaszubska, Fiona Macintyre, Sébastien Mazzuri, Jörg J Möhrle, Timothy N C Wells
A decade of discovery and development of new anti-malarial medicines has led to a renewed focus on malaria elimination and eradication. Changes in the way new anti-malarial drugs are discovered and developed have led to a dramatic increase in the number and diversity of new molecules presently in pre-clinical and early clinical development. The twin challenges faced can be summarized by multi-drug resistant malaria from the Greater Mekong Sub-region, and the need to provide simplified medicines. This review lists changes in anti-malarial target candidate and target product profiles over the last 4 years...
January 13, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28081130/comparative-ability-of-oropsylla-montana-and-xenopsylla-cheopis-fleas-to-transmit-yersinia-pestis-by-two-different-mechanisms
#9
B Joseph Hinnebusch, David M Bland, Christopher F Bosio, Clayton O Jarrett
BACKGROUND: Transmission of Yersinia pestis by flea bite can occur by two mechanisms. After taking a blood meal from a bacteremic mammal, fleas have the potential to transmit the very next time they feed. This early-phase transmission resembles mechanical transmission in some respects, but the mechanism is unknown. Thereafter, transmission occurs after Yersinia pestis forms a biofilm in the proventricular valve in the flea foregut. The biofilm can impede and sometimes completely block the ingestion of blood, resulting in regurgitative transmission of bacteria into the bite site...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28079776/enhanced-recovery-program-and-length-of-stay-after-laparotomy-on-a-gynecologic-oncology-service-a-randomized-controlled-trial
#10
Elizabeth L Dickson, Erica Stockwell, Melissa A Geller, Rachel Isaksson Vogel, Sally A Mullany, Rahel Ghebre, Boris J N Witherhoff, Levi S Downs, Linda F Carson, Deanna Teoh, Michelle Glasgow, Matt Gerber, Colleen Rivard, Britt K Erickson, Jacob Hutchins, Peter A Argenta
OBJECTIVE: To estimate whether a rapid recovery program would reduce length of stay among patients undergoing laparotomy on a gynecologic oncology service. METHODS: We conducted a prospective, randomized, controlled trial comparing an enhanced recovery after surgery protocol with routine postoperative care among women undergoing laparotomy on the gynecologic oncology service. Protocol elements included: preoperative counseling, regional anesthesia, intraoperative fluid restriction, and early postoperative ambulation and feeding...
January 9, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28079708/parenteral-nutrition-in-the-critically-ill
#11
Jan Gunst, Greet Van den Berghe
PURPOSE OF REVIEW: Feeding guidelines have recommended early, full nutritional support in critically ill patients to prevent hypercatabolism and muscle weakness. Early enteral nutrition was suggested to be superior to early parenteral nutrition. When enteral nutrition fails to meet nutritional target, it was recommended to administer supplemental parenteral nutrition, albeit with a varying starting point. Sufficient amounts of amino acids were recommended, with addition of glutamine in subgroups...
January 11, 2017: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/28076416/the-ccr2-inhibitor-propagermanium-attenuates-diet-induced-insulin-resistance-adipose-tissue-inflammation-and-non-alcoholic-steatohepatitis
#12
Petra Mulder, Anita M van den Hoek, Robert Kleemann
BACKGROUND AND AIM: Obese patients with chronic inflammation in white adipose tissue (WAT) have an increased risk of developing non-alcoholic steatohepatitis (NASH). The C-C chemokine receptor-2 (CCR2) has a crucial role in the recruitment of immune cells to WAT and liver, thereby promoting the inflammatory component of the disease. Herein, we examined whether intervention with propagermanium, an inhibitor of CCR2, would attenuate tissue inflammation and NASH development. METHODS: Male C57BL/6J mice received a high-fat diet (HFD) for 0, 6, 12 and 24 weeks to characterize the development of early disease symptoms of NASH, i...
2017: PloS One
https://www.readbyqxmd.com/read/28073390/the-behavioural-constellation-of-deprivation-causes-and-consequences
#13
Gillian V Pepper, Daniel Nettle
Socioeconomic differences in behaviour are pervasive and well documented, but their causes are not yet well understood. Here, we make the case that there is a cluster of behaviours associated with lower socioeconomic status, which we call the behavioural constellation of deprivation. We propose that the relatively limited control associated with lower socioeconomic status curtails the extent to which people can expect to realise deferred rewards, leading to more present-oriented behaviour in a range of domains...
January 11, 2017: Behavioral and Brain Sciences
https://www.readbyqxmd.com/read/28067391/gene-expression-modulation-of-lipid-and-central-energetic-metabolism-related-genes-by-high-fat-diet-intake-in-the-main-homeostatic-tissues
#14
REVIEW
Bàrbara Reynés, Mariona Palou, Andreu Palou
It is generally assumed that high-fat (HF) diets induce characteristic gene expression regulation, which may cause metabolic alterations associated with an increased risk of obesity, metabolic syndrome and other health alterations. However, an integrative analysis of the effects in different tissues is lacking, thus preventing new strategies to prevent or counteract permanent consequences. This review particularly focuses on lipid metabolism gene expression modulation in key homeostatic tissues in response to HF diet intake...
January 9, 2017: Food & Function
https://www.readbyqxmd.com/read/28067383/the-functional-consequences-and-prognostic-value-of-dosage-sensitivity-in-ovarian-cancer
#15
Zichuang Yan, Yongjing Liu, Yunzhen Wei, Ning Zhao, Qiang Zhang, Cheng Wu, Zhiqiang Chang, Yan Xu
Copy number alteration (CNA) represents an important class of genetic variations that may contribute to tumorigenesis, tumor growth and metastatic spread. CNA can directly affect the expression of genes within the CNA regions; however, genes within the CNA regions exhibit heterogeneity in gene dosage sensitivity. In this study, a computational framework was built to identify 1170 dosage-sensitive genes (DSGs) and 1215 dosage-resistant genes (DRGs) that were related to ovarian serous cystadenocarcinoma (OV) through the association between CNA and gene expression...
January 9, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28065498/consumption-of-leaves-by-platyrrhinus-lineatus-chiroptera-stenodermatinae-are-these-bats-primarily-frugivorous-or-broadly-phytophagous
#16
Patrício A da Rocha, Arivania S Pereira, Saulo M Silvestre, José Paulo Santana, Raone Beltão-Mendes, Marlon Zortéa, Stephen F Ferrari
Until now, the consumption of leaves by bats has been considered rare or sporadic, even among the herbivorous families Pteropodidae and Phyllostomidae. Among the phyllostomids there are reports of folivory in the genera Artibeus and Platyrrhinus, based on opportunistic observations. Here, we conducted behavioural sampling using camera-trapping in the roost of a colony of Platyrrhinus lineatus already known to consume leaves during the dry and wet seasons, in order to investigate the frequency of leaf consumption, as well as eventual seasonal differences...
December 29, 2016: Zoology: Analysis of Complex Systems, ZACS
https://www.readbyqxmd.com/read/28063476/short-communication-immunohistochemical-localization-of-the-immune-cell-marker-cd68-in-bovine-adipose-tissue-impact-of-tissue-alterations-and-excessive-fat-accumulation-in-dairy-cows
#17
S Häussler, D Germeroth, L Laubenthal, L F Ruda, J Rehage, S Dänicke, H Sauerwein
With the onset of lactation energy from feed intake is mostly insufficient to meet the requirements of dairy cows. Lipid mobilization from adipose tissue (AT) could lead to a compromised inflammatory response enhancing the incidence for diseases. In addition, tissue alterations can occur, displaying areas of necrosis and inflammation. Furthermore, over-conditioned cows mobilizing more lipids from AT than thin cows are prone to develop metabolic disorders. This might lead to an increased infiltration of phagocytic immune cells into AT...
January 2017: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/28063217/maternal-acculturation-and-the-growth-of-impoverished-mexican-american-infants
#18
Linda J Luecken, Shannon L Jewell, David P MacKinnon
OBJECTIVE: Identification of early life risk factors that predispose low-income Hispanic children to obesity is critical. For low-income Mexican American mothers, the cultural context may influence maternal experience and behaviors relevant to infant weight and growth. METHODS: In a longitudinal study of 322 low-income Mexican American mother-infant dyads, linear growth modeling examined the relation of maternal acculturation to infant weight gain across the first year and evaluated birth outcomes, breastfeeding, and maternal BMI as mediators...
January 7, 2017: Obesity
https://www.readbyqxmd.com/read/28062502/targeting-elastase-for-molecular-imaging-of-early-atherosclerotic-lesions
#19
Almut Glinzer, Xiaopeng Ma, Jaya Prakash, Melanie A Kimm, Fabian Lohöfer, Katja Kosanke, Jaroslav Pelisek, Moritz P Thon, Sandra Vorlova, Katrin G Heinze, Hans-Henning Eckstein, Michael W Gee, Vasilis Nitziachristos, Alma Zernecke, Moritz Wildgruber
OBJECTIVE: Neutrophils accumulate in early atherosclerotic lesions and promote lesion growth. In this study, we evaluated an elastase-specific near-infrared imaging agent for molecular imaging using hybrid fluorescence molecular tomography/x-ray computed tomography. APPROACH AND RESULTS: Murine neutrophils were isolated from bone marrow and incubated with the neutrophil-targeted near-infrared imaging agent Neutrophil Elastase 680 FAST for proof of principle experiments, verifying that the elastase-targeted fluorescent agent is specifically cleaved and activated by neutrophil content after lysis or cell stimulation...
December 29, 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28061799/ralstonia-picketti-neonatal-sepsis-a-case-report
#20
Deepak Sharma, Pradeep Sharma, Priyanka Soni, Basudev Gupta
BACKGROUND: Ralstonia genus are gram negative bacillus and includes four bacteria namely Ralstonia picketti, Ralstonia Solanacearum, Ralstonia insidiosa and Ralstonia mannitolilytica. These are opportunistic pathogens and cause infections in immunocompromised host. The sources of infection are usually contaminated solutions and water. The majority of the reported cases are caused by R. picketti. It is very rare cause of neonatal sepsis with less than twenty cases reported in literature till date...
January 7, 2017: BMC Research Notes
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