keyword
MENU ▼
Read by QxMD icon Read
search

neurological disease

keyword
https://www.readbyqxmd.com/read/29235420/a-self-care-problem-solving-and-mindfulness-intervention-for-informal-caregivers-of-people-with-motor-neurone-disease-a-pilot-study
#1
Anna Ugalde, Susan Mathers, Nicole Hennessy Anderson, Peter Hudson, Liliana Orellana, Cathy Gluyas
BACKGROUND: Informal caregivers of people with motor neurone disease (MND) take on an extensive role. Caregivers are at increased risk of experiencing psychological distress and burden, yet, there is a lack of intervention programmes to support them. AIM: The aim of this study was to investigate the feasibility and acceptability of a therapeutic group intervention promoting self-care, problem-solving and mindfulness to informal caregivers of people with MND. DESIGN: Pilot study that utilised a one-arm pre- and post-design...
November 1, 2017: Palliative Medicine
https://www.readbyqxmd.com/read/29235414/zikaplan-zika-preparedness-latin-american-network
#2
A Wilder-Smith, R Preet, K E Renhorn, R A Ximenes, L C Rodrigues, T Solomon, J Neyts, L Lambrechts, H Willison, R Peeling, A K Falconar, A R Precioso, J Logan, T Lang, H P Endtz, M C Erasmus, E Massad
The ongoing Zika virus (ZIKV) outbreak in Latin America, the Caribbean, and the Pacific Islands has underlined the need for a coordinated research network across the whole region that can respond rapidly to address the current knowledge gaps in Zika and enhance research preparedness beyond Zika. The European Union under its Horizon 2020 Research and Innovation Programme awarded three research consortia to respond to this need. Here we present the ZikaPLAN (Zika Preparedness Latin American Network) consortium...
2017: Global Health Action
https://www.readbyqxmd.com/read/29234571/measurement-of-elevated-il-37-levels-in-acute-ischemic-brain-injury-a-cross-sectional-pilot-study
#3
Atif Zafar, Asad Ikram, Dinesh V Jillella, Duraisamy Kempuraj, Mohammad Moshahid Khan, Saif Bushnaq, Harold Adam, Santiago Ortega-Gutierrez, Syed A Quadri, Mudassir Farooqui, Asgar Zaheer, Enrique C Leira
Interleukin (IL)-37 is a new member of the IL-1 cytokine family with a defined role as a negative feedback inhibitor of proinflammatory responses. IL-37 has yet to be evaluated in non-immune-mediated neurological diseases, such as ischemic or hemorrhagic strokes. This study aimed to measure urine and serum IL-37 levels in patients with ischemic stroke. Twelve patients consented for our study. Two sets of serum and urine samples were obtained and analyzed, one upon admission to the hospital and the second the next morning...
October 11, 2017: Curēus
https://www.readbyqxmd.com/read/29234418/effects-of-acupuncture-on-alzheimer-s-disease-in-animal-based-research
#4
REVIEW
Sunjung Park, Jun-Hwan Lee, Eun Jin Yang
Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by the accumulation of amyloid beta (Aβ) plaques, neurofibrillary tangles, and severe functional deficits in the brain. The pathogenesis and treatment of AD remain topics of investigation and significant global socioeconomic issues. The effect of complementary medicine has been investigated in managing AD. Acupuncture, a form of therapy practiced for more than 3000 years, has shown positive effects on several neurological disorders including AD...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29234304/hypothesis-on-the-role-of-cryptochromes-in-inflammation-and-subarachnoid-hemorrhage-outcome
#5
Adriano Barreto Nogueira, Ariel Barreto Nogueira, José Carlos Esteves Veiga, Manoel Jacobsen Teixeira
We have recently found that the temperature variability (TV) in the day-night cycle may predict the mean intracranial pressure in the following 24 h (ICP24) in subarachnoid hemorrhage (SAH) patients under multimodality monitoring, sedation, and hypothermia (<35°C). Specifically, we found that ICP24 = 6 (4 - TV) mmHg. TV is the ratio between the coefficient of variation of temperature during the nocturnal and the preceding diurnal periods. This result suggests that the circadian clock reflects brain plasticity mechanisms and its malfunctioning leads to deterioration of the neurologic status...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29234271/the-enigmatic-role-of-gba2-in-controlling-locomotor-function
#6
REVIEW
Marina A Woeste, Dagmar Wachten
The non-lysosomal glucosylceramidase GBA2 catalyzes the hydrolysis of glucosylceramide to glucose and ceramide. Loss of GBA2 function results in accumulation of glucosylceramide. Mutations in the human GBA2 gene have been associated with hereditary spastic paraplegia (HSP) and autosomal-recessive cerebellar ataxia (ARCA). Patients suffering from these disorders exhibit impaired locomotion and neurological abnormalities. GBA2 mutations found in these patients have been proposed to impair GBA2 function. However, the molecular mechanism underlying the occurrence of mutations in the GBA2 gene and the development of locomotor dysfunction is not well-understood...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29233794/relevance-of-4-f4t-neuroprostane-and-10-f4t-neuroprostane-to-neurological-diseases
#7
Cinzia Signorini, Claudio De Felice, Thierry Durand, Jean-Marie Galano, Camille Oger, Silvia Leoncini, Lucia Ciccoli, Marisa Carone, Monica Ulivelli, Caterina Manna, Alessio Cortelazzo, Jetty Chung-Yung Lee, Joussef Hayek
F4-neuroprostanes (F4-NeuroPs) are non-enzymatic oxidized products derived from docosahexaenoic acid (DHA) and are suggested to be oxidative damage biomarkers of neurological diseases. However, 128 isomers can be formed from DHA oxidation and among them, 4(RS)-4-F4t-NeuroP (4-F4t-NeuroP) and 10(RS)-10-F4t-NeuroP (10-F4t-NeuroP) are the most studied. Here, we report the identification and the clinical relevance of 4-F4t-NeuroP and 10-F4t-NeuroP in plasma of four different neurological diseases, including multiple sclerosis (MS), autism spectrum disorders, (ASD) Rett syndrome (RTT), and Down syndrome (DS)...
December 9, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29233744/a-flavonoid-compound-library-screen-revealed-potent-antiviral-activity-of-plant-derived-flavonoids-on-human-enterovirus-a71-replication
#8
Nyo Min, Leong Pok Thim, Regina Ching Hua Lee, Jeffery Seng Eng Khuan, Justin Jang Hann Chu
Hand Foot Mouth Disease (HFMD), resulting from human enterovirus A71 (HEVA71) infection can cause severe neurological complications leading to fatality in young children. Currently, there is no approved antiviral for therapeutic treatment against HEVA71 infection. In this study, a 500-compound flavonoid library was screened to identify potential inhibitors of HEVA71 using high-throughput immunofluorescence-based phenotypic screening method. Two lead flavonoid compounds, ST077124 and ST024734 at the non-cytotoxic concentration of 50 μM were found to be effective antivirals that inhibited replication of HEVA71, reducing infectious viral titers by 3...
December 9, 2017: Antiviral Research
https://www.readbyqxmd.com/read/29233654/trophic-modulation-of-gamma-oscillations-the-key-role-of-processing-protease-for-neuregulin-1-and-bdnf-precursors
#9
Hideki Tamura, Sadao Shiosaka, Shota Morikawa
Gamma oscillations within the cerebral cortex and hippocampus are associated with cognitive processes, including attention, sensory perception, and memory formation; a deficit in gamma regulation is a common symptom of neurologic and psychiatric disorders. Accumulating evidence has suggested that gamma oscillations result from the synchronized activity of cell assemblies coordinated mainly by parvalbumin-positive inhibitory interneurons. The modulator molecules for parvalbumin-positive interneurons are major research targets and have the potential to control the specific oscillatory rhythm and behavior originating from neural coordination...
December 9, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/29233038/juvenile-systemic-lupus-erythematosus-in-turkey-demographic-clinical-and-laboratory-features-with-disease-activity-and-outcome
#10
S Sahin, A Adrovic, K Barut, N Canpolat, Y Ozluk, I Kilicaslan, S Caliskan, L Sever, O Kasapcopur
Objectives This paper aims to assess in a retrospective fashion the clinical and laboratory features, severity and outcome of juvenile systemic lupus erythematosus (jSLE) from a referral center in Turkey. Methods We have included all jSLE patients ( n = 92) diagnosed according to the revised American College of Rheumatology 1997 criteria between January 2004 and January 2017. Results The most prevalent clinical feature in our cohort was mucocutaneous manifestations (97.8%), followed by constitutional (81...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/29232946/huntingtin-polyglutamine-dependent-protein-aggregation-in-reconstituted-cells
#11
Kodai Machida, Kuru Kanzawa, Tomoaki Shigeta, Yuki Yamamoto, Kanta Tsumoto, Hiroaki Imataka
One of the aims of synthetic biology is bottom-up construction of reconstituted human cells for medical uses. To that end, we generated giant unilamella vesicles (GUVs) that contained a HeLa cell extract, which comprises a cell-free protein synthesis (CFPS) system. Then we expressed Huntingtin protein fragments that contained polyglutamine (polyQ) sequences (Htt-polyQ), a hallmark of Huntington's disease. That system produced polyQ-dependent protein aggregates, as previously demonstrated in living cells. We next simplified the system by generating GUVs that contained purified human factors, which reconstituted a CFPS system...
December 12, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/29231910/-clinical-pictures-of-borreliosis
#12
EDITORIAL
Tadeusz Płusa
Lyme disease occurs in a variety of clinical manifestations, ranging from skin lesions, through musculoskeletal, neurological, and cardiac syndrome, to severe irreversible lesions. Borrelia burgdorferi's organotropy has an impact on the development of the disease. In initial management, it is important to implement effective treatment to prevent further progression of infection. Dominant skin lesions should be differentiated in detail. In the form of disseminated disease complex of clinical syndromes is observed but it requires of confirmation in immunoassays...
November 23, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29231488/-clinical-data-analysis-of-279-inpatients-with-acupuncture-consultation-in-a-comprehensive-hospital
#13
Yamin Zhang, Hua Sun, Suhui Chen, Hong Xu, Fei Bao
OBJECTIVE: To analyze the current status of acupuncture consultation in Peking Union Medical College Hospital, which could provide references and suggestions for the development of acupuncture at comprehensive hospitals and the treatment of diseases. METHODS: The source of departments, the number of patients, the number of consultation, treatment frequency, consultation reasons and western medicine diagnosis of 279 inpatients who received acupuncture consultation were analyzed...
February 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231065/serum-interleukin-6-levels-as-an-indicator-of-aseptic-meningitis-among-children-with-enterovirus-71-induced-hand-foot-and-mouth-disease
#14
Joo Young Lee, Minji Son, Jin Han Kang, Ui Yoon Choi
OBJECTIVES: The enterovirus EV71 is a major pathogen of hand, foot, and mouth disease (HFMD) in children. Aseptic meningitis is the most common neurologic complication of EV71-induced HFMD. Lumbar puncture is a crucial procedure in the diagnosis of aseptic meningitis. It is often performed based on physicians' clinical suspicion. A diagnostic method that can aid in deciding whether this procedure should be performed is necessary. Cytokines are speculated to be associated with neurologic complications...
December 14, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/29230179/transplacental-nutrient-transport-mechanisms-of-intrauterine-growth-restriction-in-rodent-models-and-humans
#15
REVIEW
Elke Winterhager, Alexandra Gellhaus
Although the causes of intrauterine growth restriction (IUGR) have been intensively investigated, important information is still lacking about the role of the placenta as a link from adverse maternal environment to adverse pregnancy outcomes of IUGR and preterm birth. IUGR is associated with an increased risk of cardiovascular, metabolic, and neurological diseases later in life. Determination of the most important pathways that regulate transplacental transport systems is necessary for identifying marker genes as diagnostic tools and for developing drugs that target the molecular pathways...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29230170/the-dancing-brain-structural-and-functional-signatures-of-expert-dance-training
#16
Agnieszka Z Burzynska, Karolina Finc, Brittany K Taylor, Anya M Knecht, Arthur F Kramer
Dance - as a ritual, therapy, and leisure activity - has been known for thousands of years. Today, dance is increasingly used as therapy for cognitive and neurological disorders such as dementia and Parkinson's disease. Surprisingly, the effects of dance training on the healthy young brain are not well understood despite the necessity of such information for planning successful clinical interventions. Therefore, this study examined actively performing, expert-level trained college students as a model of long-term exposure to dance training...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29230021/markers-of-microglia-in-post-mortem-brain-samples-from-patients-with-alzheimer-s-disease-a-systematic-review
#17
REVIEW
K E Hopperton, D Mohammad, M O Trépanier, V Giuliano, R P Bazinet
Neuroinflammation is proposed as one of the mechanisms by which Alzheimer's disease pathology, including amyloid-β plaques, leads to neuronal death and dysfunction. Increases in the expression of markers of microglia, the main neuroinmmune cell, are widely reported in brains from patients with Alzheimer's disease, but the literature has not yet been systematically reviewed to determine whether this is a consistent pathological feature. A systematic search was conducted in Medline, Embase and PsychINFO for articles published up to 23 February 2017...
December 12, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29229897/integrative-analysis-to-identify-common-genetic-markers-of-metabolic-syndrome-dementia-and-diabetes
#18
Weihong Zhang, Linlin Xin, Ying Lu
BACKGROUND Emerging data have established links between systemic metabolic dysfunction, such as diabetes and metabolic syndrome (MetS), with neurocognitive impairment, including dementia. The common gene signature and the associated signaling pathways of MetS, diabetes, and dementia have not been widely studied. MATERIAL AND METHODS We exploited the translational bioinformatics approach to choose the common gene signatures for both dementia and MetS. For this we employed "DisGeNET discovery platform". RESULTS Gene mining analysis revealed that a total of 173 genes (86 genes common to all three diseases) which comprised a proportion of 43% of the total genes associated with dementia...
December 12, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29229894/retrospective-review-of-pediatric-status-epilepticus-in-116-saudi-patients-predictors-of-outcome
#19
Raid Harb Hommady, Muhammad Talal Alrifai, Osama Khaled Mubayrik, Ruba Salem Alayed, Muhannad Abdulrahman Alsemari, Ahmed Arumayyan, Waleed Altuwaijri, Duaa Baarmah
BACKGROUND: Status epilepticus (SE) is a common, life-threatening condition. Multiple factors are used to predict its outcome and evaluate its risks, and there have been only a few studies in Saudi Arabia. OBJECTIVES: Investigate predictors of SE outcome. DESIGN: Retrospective chart review study. SETTING: Tertiary center, Riyadh. PATIENTS AND METHODS: We reviewed all pediatric cases (age 14 years or younger) of SE admitted between January 2005 and December 2015, collecting data on age, sex, date of birth, developmental status, pre-existing neurological diseases, SE etiology, Glasgow Outcome Scale (GOS) scores, and electroencephalogram (EEG) findings...
November 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/29229845/brain-urea-increase-is-an-early-huntington-s-disease-pathogenic-event-observed-in-a-prodromal-transgenic-sheep-model-and-hd-cases
#20
Renee R Handley, Suzanne J Reid, Rudiger Brauning, Paul Maclean, Emily R Mears, Imche Fourie, Stefano Patassini, Garth J S Cooper, Skye R Rudiger, Clive J McLaughlan, Paul J Verma, James F Gusella, Marcy E MacDonald, Henry J Waldvogel, C Simon Bawden, Richard L M Faull, Russell G Snell
The neurodegenerative disorder Huntington's disease (HD) is typically characterized by extensive loss of striatal neurons and the midlife onset of debilitating and progressive chorea, dementia, and psychological disturbance. HD is caused by a CAG repeat expansion in the Huntingtin (HTT) gene, translating to an elongated glutamine tract in the huntingtin protein. The pathogenic mechanism resulting in cell dysfunction and death beyond the causative mutation is not well defined. To further delineate the early molecular events in HD, we performed RNA-sequencing (RNA-seq) on striatal tissue from a cohort of 5-y-old OVT73-line sheep expressing a human CAG-expansion HTT cDNA transgene...
December 11, 2017: Proceedings of the National Academy of Sciences of the United States of America
keyword
keyword
58024
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"