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https://www.readbyqxmd.com/read/29351672/high-treatment-success-rate-among-multidrug-resistant-tuberculosis-patients-in-myanmar-2012-2014-a-retrospective-cohort-study
#1
Myat K Thu, Ajay M V Kumar, Kyaw T Soe, Saw Saw, Saw Thein, Zaw Mynit, Htet M W Maung, Si T Aung
Background: Since 2011, Myanmar has adopted domiciliary care for multidrug-resistant tuberculosis (MDR-TB) patients and implemented several patient-support measures such as community-based directly observed treatment, nutritional support and financial incentives for patients and providers. We assessed treatment outcomes among MDR-TB patients registered for treatment in the Yangon and Mandalay Regions of Myanmar during 2012-2014 and factors associated with unfavourable treatment outcomes...
January 17, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29351128/fluid-removal-with-ultrasound-guided-protocol-improves-the-efficacy-and-safety-of-dehydration-in-post-resuscitated-critically-ill-patients-a-quasi-experimental-before-and-after-study
#2
Luhao Wang, Chunfang Qiu, Xiangdong Guan, Minying Chen, Juan Chen, Xiang Si, Zhicheng Du, Yanqiu Liu, Bin Ouyang
Fluid overload is associated with increased morbidity and mortality in critically ill patients. However, researches rarely study the precise start or end point of fluid removal and no protocol was developed to control the fluid removal process. We hypothesized that individualized fluid removal with ultrasound-guided protocol could improve the efficacy and safety of fluid removal in post-resuscitated critically ill patients. A quasi-experimental, before and after trial was conducted to identify the benefits of ultrasound-guided fluid removal...
January 18, 2018: Shock
https://www.readbyqxmd.com/read/29350730/three-dimensional-porous-sic-for-lithium-polysulfide-trapping
#3
Fen Li, Jijun Zhao
One of the key issues in lithium sulfur batteries is the fast capacity fade induced by the lithium polysulfide (LiPS) migration. Hence, a series of three-dimensional (3D) porous SiC materials with active sp2 Si atoms have been designed for lithium polysulfide entrapping in Li-S batteries. The ZGM-SiC-1 and AGM-SiC-3 have been confirmed to be thermodynamically and dynamically stable from the formation energy and phonon dispersion spectrum, meanwhile showing good mechanical properties. The moderate band gaps suggest fast electron transport during the charge-discharge cycles of the Li-S batteries, especially in ZGM-SiC-1...
January 19, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29350445/application-of-computer-aided-sperm-analysis-casa-for-detecting-sperm-immobilizing-antibody
#4
Yu Wakimoto, Atsushi Fukui, Teruhito Kojima, Akiko Hasegawa, Minoru Shigeta, Hiroaki Shibahara
PROBLEM: Since the 1970s, anti-sperm antibodies have been studied as a pathogenic factor contributing to infertility. The complement-dependent sperm-immobilization test (SIT) and quantitative SIT have been used as effective tools for detecting anti-sperm antibodies in clinical settings. These tests have been carried out traditionally by manually counting the number of motile sperm through eye estimation. METHOD OF STUDY: In this study, we developed a novel method using computer-aided sperm analysis...
January 19, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29350407/recent-progress-in-the-antiviral-activity-and-mechanism-study-of-pentacyclic-triterpenoids-and-their-derivatives
#5
REVIEW
Sulong Xiao, Zhenyu Tian, Yufei Wang, Longlong Si, Lihe Zhang, Demin Zhou
Viral infections cause many serious human diseases with high mortality rates. New drug-resistant strains are continually emerging due to the high viral mutation rate, which makes it necessary to develop new antiviral agents. Compounds of plant origin are particularly interesting. The pentacyclic triterpenoids (PTs) are a diverse class of natural products from plants composed of three terpene units. They exhibit antitumor, anti-inflammatory, and antiviral activities. Oleanolic, betulinic, and ursolic acids are representative PTs widely present in nature with a broad antiviral spectrum...
January 19, 2018: Medicinal Research Reviews
https://www.readbyqxmd.com/read/29349799/simultaneous-lc-ms-ms-bioanalysis-of-etoposide-and-paclitaxel-in-mouse-tissues-and-plasma-after-oral-administration-of-self-microemulsifying-drug-delivery-systems
#6
Dan Li, Gang Zhao, Weipeng Ai, Gao Li, Luqin Si, Jiangeng Huang, Yunzhou Chen, Sanlan Wu
In this study, a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated to simultaneously determine the anticancer drugs etoposide and paclitaxel in mouse plasma and tissues including liver, kidney, lung, heart, spleen and brain. The analytes were extracted from the matrices of interest by liquid-liquid extraction using DCM: MTBE (1:1, v/v). Chromatographic separation was achieved on an Ultimate XB-C18 column (100 mm × 2.1 mm, 3 μm) at 40 °C and the total run time was 4 min under a gradient elution...
January 19, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29349585/molecularly-imprinted-core-shell-cdse-sio2-cds-as-a-ratiometric-fluorescent-probe-for-4-nitrophenol-sensing
#7
Mingyue Liu, Zhao Gao, Yanjun Yu, Rongxin Su, Renliang Huang, Wei Qi, Zhimin He
4-Nitrophenol (4-NP) is a priority pollutant in water and is both carcinogenic and genotoxic to humans and wildlife even at very low concentrations. Thus, we herein fabricated a novel molecularly imprinted core-shell nanohybrid as a ratiometric fluorescent sensor for the highly sensitive and selective detection of 4-NP. This sensor was functioned by the transfer of fluorescence resonance energy between photoluminescent carbon dots (CDs) and 4-NP. This sensor was synthesized by linking organosilane-functionalized CDs to silica-coated CdSe quantum dots (CdSe@SiO2) via Si-O bonds...
January 18, 2018: Nanoscale Research Letters
https://www.readbyqxmd.com/read/29349503/is-there-any-difference-between-open-and-arthroscopic-treatment-for-osteochondritis-dissecans-ocd-of-the-humeral-capitellum-a-systematic-review-and-meta-analysis
#8
Yi Lu, Yi Jun Li, Si Yi Guo, Hai Long Zhang
PURPOSE: We present a systematic review of the recent literatures regarding the arthroscopic and open technique in fragment fixation for osteochondritis dissecans (OCD) of the humeral capitellum and an analysis of the subjective and objective outcomes between these two procedures. METHODS: PubMed and EMBASE were reviewed for suitable articles relating to fragment fixation for OCD, both open and arthroscopic. We included all studies reporting on the clinical outcomes of these two procedures that were published in the English language...
January 18, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29348893/diagnostic-accuracy-of-dna-methylation-in-detection-of-gastric-cancer-a-meta-analysis
#9
Weiling Hu, Wenfang Zheng, Qifang Liu, Hua Chu, Shujie Chen, John J Kim, Jiaguo Wu, Jianmin Si
Emerging studies demonstrate the diagnostic utility of DNA methylation-based blood test for gastric cancer. The aim of the meta-analysis is to evaluate the accuracy of blood DNA methylation markers for detecting patients with gastric cancer. A systematic literature search to November 2016 that evaluated DNA methylation markers utilizing blood specimen to detect gastric cancer were selected to derive pooled sensitivities and specificities. 32 studies including 4,172 patients (gastric cancer (N = 2,098), control (N = 2,074)) met the study criteria...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29348859/the-effect-of-systematic-lower-limb-rehabilitation-training-in-elderly-patients-undergoing-lumbar-fusion-surgery-a-retrospective-study
#10
Si-Kai Liu, Yan-Li Song, Wen-Yuan Ding, Da-Long Yang, Lei Ma, Si-Dong Yang
Objectives: The purpose of this study was to explore the effect of systematic lower-limb rehabilitation training in elderly patients undergoing lumbar fusion surgery due to serious degenerative intervertebral disc diseases. Results: At the 1st week after surgery, clinical rehabilitation effect in intervention group was better regarding lower-limb muscle strength, lower-limb DVT, VAS score, and ODI, as compared with control group (all p < 0.05). During the first two weeks after surgery, satisfaction rate in intervention group was higher than that in control group...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29348536/surround-inhibition-can-instantly-be-modulated-by-changing-the-attentional-focus
#11
Yves-Alain Kuhn, Martin Keller, Benedikt Lauber, Wolfgang Taube
To further investigate the mechanism of surround inhibition (SI) and to determine whether adopting different attentional strategies might have an impact on the modulation of SI, the effects of adopting an external (EF) or internal focus of attention (IF) on SI and motor performance were investigated. While performing an index flexion with either an EF or IF, transcranial magnetic stimulation was applied at various time points in 14 healthy subjects. When adopting an EF compared to an IF, the results show an improved motor performance (+14...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348189/cancer-stem-cell-phenotypes-in-er-breast-cancer-models-are-promoted-by-pelp1-aib1-complexes
#12
Thu H Truong, Hsiangyu Hu, Nuri A Temiz, Kyla Hagen, Brian J Girard, Nicholas J Brady, Kathryn L Schwertfeger, Carol A Lange, Julie H Ostrander
Proline, glutamic acid, and leucine rich protein 1 (PELP1) is overexpressed in approximately 80% of invasive breast tumors. PELP1 dynamically shuttles between the nucleus and cytoplasm, but is primarily nuclear in normal breast tissue. However, altered localization of PELP1 to the cytoplasm is an oncogenic event that promotes breast cancer initiation and progression. Herein, interacting partners unique to cytoplasmic PELP1 and the mechanisms by which these interactions promote oncogenic PELP1 signaling were sought...
January 18, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29347625/modeling-of-the-interaction-of-an-x-ray-free-electron-laser-with-large-finite-samples
#13
O Peyrusse, J-M André, P Jonnard, J Gaudin
We describe a model for the study of the interaction of short x-ray free-electron laser (XFEL) pulses with large finite samples. Hydrodynamics is solved in one-dimensional planar geometry with consideration of the electron-ion energy exchange and of the possible elastoplastic behavior. From a time-dependent calculation of the complex refractive index and of the underlying atomic physics, XFEL energy deposition is modeled through a calculation of the radiation field in the material. In the case of hard x-ray irradiation, energetic electrons induced by the XFEL absorption can propagate and deposit their energy outside the interaction region...
October 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347088/effect-of-polymer-additives-on-heat-transport-and-large-scale-circulation-in-turbulent-rayleigh-b%C3%A3-nard-convection
#14
Jian-Ping Cheng, Hong-Na Zhang, Wei-Hua Cai, Si-Ning Li, Feng-Chen Li
The present paper presents direct numerical simulations of Rayleigh-Bénard convection (RBC) in an enclosed cell filled with the polymer solution in order to investigate the viscoelastic effect on the characteristics of heat transport and large-scale circulation (LSC) of RBC. To overcome the difficulties in numerically solving a high Weissenberg number (Wi) problem of viscoelastic fluid flow with strong elastic effect, the log-conformation reformulation method was implemented. Numerical results showed that the addition of polymers reduced the heat flux and the amount of heat transfer reduction (HTR) behaves nonmonotonically, which firstly increases but then decreases with Wi...
July 2017: Physical Review. E
https://www.readbyqxmd.com/read/29346765/characterization-of-endothelial-cells-associated-with-hematopoietic-niche-formation-in-humans-identifies-il-33-as-an-anabolic-factor
#15
Keane Jared Guillaume Kenswil, Adrian Christopher Jaramillo, Zhen Ping, Si Chen, Remco Michiel Hoogenboezem, Maria Athina Mylona, Maria Niken Adisty, Eric Moniqué Johannes Bindels, Pieter Koen Bos, Hans Stoop, King Hong Lam, Bram van Eerden, Tom Cupedo, Marc Hermanus Gerardus Petrus Raaijmakers
Bone marrow formation requires an orchestrated interplay between osteogenesis, angiogenesis, and hematopoiesis that is thought to be mediated by endothelial cells. The nature of the endothelial cells and the molecular mechanisms underlying these events remain unclear in humans. Here, we identify a subset of endoglin-expressing endothelial cells enriched in human bone marrow during fetal ontogeny and upon regeneration after chemotherapeutic injury. Comprehensive transcriptional characterization by massive parallel RNA sequencing of these cells reveals a phenotypic and molecular similarity to murine type H endothelium and activation of angiocrine factors implicated in hematopoiesis, osteogenesis, and angiogenesis...
January 16, 2018: Cell Reports
https://www.readbyqxmd.com/read/29346289/himawari-8-satellite-based-dynamic-monitoring-of-grassland-fire-in-china-mongolia-border-regions
#16
Li Na, Jiquan Zhang, Yulong Bao, Yongbin Bao, Risu Na, Siqin Tong, Alu Si
In this study, we used bands 7, 4, and 3 of the Advance Himawari Imager (AHI) data, combined with a Threshold Algorithm and a visual interpretation method to monitor the entire process of grassland fires that occurred on the China-Mongolia border regions, between 05:40 (UTC) on April 19th to 13:50 (UTC) on April 21st 2016. The results of the AHI data monitoring are evaluated by the fire point product data, the wind field data, and the environmental information data of the area in which the fire took place. The monitoring result shows that, the grassland fire burned for two days and eight hours with a total burned area of about 2708...
January 18, 2018: Sensors
https://www.readbyqxmd.com/read/29345956/measuring-three-dimensional-strain-and-structural-defects-in-a-single-ingaas-nanowire-using-coherent-x-ray-multi-angle-bragg-projection-ptychography
#17
Megan O Hill, Irene Calvo-Almazan, Mark Allain, Martin Holt, Andrew Ulvestad, Julian Treu, Gregor Koblmueller, Chunyi Huang, Xiaojing Huang, Hanfei Yan, E Nazarestski, Yong S Chu, G Brian Stephenson, Virginie Chamard, Lincoln Lauhon, Stephan O Hruszkewycz
III-As nanowires are candidates for near infrared light emitters and detectors that can be directly integrated onto silicon. However, nanoscale to microscale variations in structure, composition, and strain within a given nanowire, as well as variations between nanowires, pose challenges to correlating microstructure with device performance. In this work, we utilize coherent nano-focused x-rays to characterize stacking defects and strain in a single InGaAs nanowire supported on Si. By reconstructing diffraction patterns from the 2-1-10 Bragg peak, we show that the lattice orientation varies along the length of the wire, while the strain field along the cross-section is largely unaffected, leaving the band structure unperturbed...
January 18, 2018: Nano Letters
https://www.readbyqxmd.com/read/29345903/light-emitting-diodes-based-on-colloidal-silicon-quantum-dots-with-octyl-and-phenylpropyl-ligands
#18
Xiangkai Liu, Shuangyi Zhao, Wei Gu, Yuting Zhang, Xvsheng Qiao, Zhenyi Ni, Xiaodong Pi, Deren Yang
Colloidal silicon quantum dots (Si QDs) hold ever-growing promise for the development of novel optoelectronic devices such as light-emitting diodes (LEDs). Although it has been proposed that ligands at the surface of colloidal Si QDs may significantly impact the performance of LEDs based on colloidal Si QDs, little systematic work has been carried out to compare the performance of LEDs that are fabricated by using colloidal Si QDs with different ligands. Here colloidal Si QDs with rather short octyl ligands (Octyl-Si QDs) and phenylpropyl ligands (PhPr-Si QDs) are employed for the fabrication of LEDs...
January 18, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29345456/pre-occupation-of-empty-carriers-decreases-endo-lysosome-escape-and-reduces-the-protein-delivery-efficiency-of-mesoporous-silica-nanoparticles
#19
Wenqing Li, Liping Sun, Yiqiu Xia, Si-Jie Hao, Gong Cheng, Zhigang Wang, Yuan Wan, Chuandong Zhu, Hongzhang He, Si-Yang Zheng
Endo/lysosome escape is a major challenge in nanoparticles-based protein delivery for cancer therapy. To enhance endo/lysosomal escape and increase the efficacy of proteins delivery, current strategies mainly focuses on destroying endo/lysosomes by employing modified nanoparticles, such as pH-sensitive polyplexes, cell-penetrating peptides, and photosensitive molecules. Herein, we hypothesize that pre-treatment with empty nanocarriers might make endo/lysosomes occupied and affect the endo/lysosomal escape of subsequent protein delivery by nanocarriers...
January 18, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29345254/the-mtor-inhibitor-azd8055-overcomes-tamoxifen-resistance-in-breast-cancer-cells-by-down-regulating-hspb8
#20
Jia-Jie Shi, Si-Meng Chen, Chen-Liang Guo, Yi-Xue Li, Jian Ding, Ling-Hua Meng
Tamoxifen, an important endocrine therapeutic agent, is widely used for the treatment of estrogen receptor positive (ER+) breast cancer. However, de novo or acquired resistance prevents patients from benefitting from endocrine approaches and necessitates alternative treatments. In this study, we report that small heat protein beta-8 (HSPB8) may serve as an important molecule in tamoxifen resistance. HSPB8 expression is enhanced in MCF-7 cells resistant to tamoxifen (MCF-7/R) compared to parent cells. Moreover, high expression of HSPB8 associates with poor prognosis in ER+ breast cancer patients but not in patients without classification...
January 18, 2018: Acta Pharmacologica Sinica
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