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https://www.readbyqxmd.com/read/29783142/assessment-of-microbial-products-in-the-biosorption-process-of-cu-ii-onto-aerobic-granular-sludge-extracellular-polymeric-substances-contribution-and-soluble-microbial-products-release
#1
Linxian Huang, Meilin Li, Guangchao Si, Jinglin Wei, Huu Hao Ngo, Wenshan Guo, Weiying Xu, Bin Du, Qin Wei, Dong Wei
In the present study, the responses of microbial products in the biosorption process of Cu(II) onto aerobic granular sludge were evaluated by using batch and spectroscopic approaches. Batch experimental data showed that extracellular polymeric substances (EPSs) contributed to Cu(II) removal from an aqueous solution, especially when treating low metal concentrations, whereas soluble microbial products (SMPs) were released under the metal stress during biosorption process. A three-dimensional excitation-emission matrix (3D-EEM) identified four main fluorescence peaks in the EPS, i...
May 18, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29783080/development-and-characterization-of-a-field-effect-biosensor-for-the-detection-of-acetoin
#2
Denise Molinnus, Lukas Muschallik, Laura Osorio Gonzalez, Johannes Bongaerts, Torsten Wagner, Thorsten Selmer, Petra Siegert, Michael Keusgen, Michael J Schöning
A capacitive electrolyte-insulator-semiconductor (EIS) field-effect biosensor for acetoin detection has been presented for the first time. The EIS sensor consists of a layer structure of Al/p-Si/SiO2 /Ta2 O5 /enzyme acetoin reductase. The enzyme, also referred to as butane-2,3-diol dehydrogenase from B. clausii DSM 8716T , has been recently characterized. The enzyme catalyzes the (R)-specific reduction of racemic acetoin to (R,R)- and meso-butane-2,3-diol, respectively. Two different enzyme immobilization strategies (cross-linking by using glutaraldehyde and adsorption) have been studied...
May 18, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29783077/effects-of-prolonged-exposure-and-virtual-reality-exposure-on-suicidal-ideation-in-active-duty-soldiers-an-examination-of-potential-mechanisms
#3
REVIEW
Aaron M Norr, Derek J Smolenski, Greg M Reger
OBJECTIVE: The current study sought to investigate the effects of exposure therapy on suicidal ideation (SI), as well as potential mechanistic pathways of SI reduction among active duty military personnel. METHODS: Active duty army soldiers (N = 162) were recruited from a military base in the U.S. and were enrolled in a randomized clinical trial comparing Prolonged Exposure (PE), Virtual Reality Exposure (VRE), and a wait-list control for the treatment of posttraumatic stress disorder (PTSD) stemming from deployments to Iraq or Afghanistan...
May 12, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29782802/pt-single-atoms-embedded-in-the-surface-of-ni-nanocrystals-as-highly-active-catalysts-for-selective-hydrogenation-of-nitro-compounds
#4
Yuhan Peng, Zhigang Geng, Songtao Zhao, Liangbing Wang, Hongliang Li, Xu Wang, XuSheng Zheng, Junfa Zhu, Zhenyu Li, Rui Si, Jie Zeng
Single-atom catalysts exhibit high selectivity in hydrogenation due to their isolated active sites which ensure uniform adsorption configurations of substrate molecules. Compared with the achievement in catalytic selectivity, there is still a long way to go in exploiting the catalytic activity of single-atom catalysts. Herein, we developed highly active and selective catalysts in selective hydrogenation by embedding Pt single atoms in the surface of Ni nanocrystals (denoted as Pt1/Ni nanocrystals). During the hydrogenation of 3-nitrostyrene, the TOF numbers based on surface Pt atoms of Pt1/Ni nanocrystals reached ~1800 h-1 under 3 atm of H2 at 40 oC, much higher than that of Pt single atoms supported on active carbon, TiO2, SiO2, and ZSM-5...
May 21, 2018: Nano Letters
https://www.readbyqxmd.com/read/29782675/hierarchical-micro-nanostructures-from-human-hair-for-biomedical-applications
#5
Di-Wei Zheng, Sheng Hong, Lu Xu, Chu-Xin Li, Ke Li, Si-Xue Cheng, Xian-Zheng Zhang
With the prominent progress of biomedical engineering, materials with high biocompatibility and versatile functions are urgently needed. So far, hierarchical structures in nature have shed some light on the design of high performance materials both in concept and implementation. Inspired by these, the hierarchical micro-/nanostructures of human hair are explored and human hair is further broken into hierarchical microparticles (HMP) and hierarchical nanoparticles (HNP) with top-down procedures. Compared with commercialized carriers, such as liposomes or albumin nanoparticles, the obtained particles exhibit high hemocompatibility and negligible immunogenicity...
May 21, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29782350/effect-of-pyruvate-kinase-m2-regulating-aerobic-glycolysis-on-chemotherapy-resistance-of-estrogen-receptor-positive-breast-cancer
#6
Yuejun Qian, Lina Bi, Yingxu Yang, Dong Wang
This study aims to explore the effect and mechanism of pyruvate kinase M2 (PKM2) on chemotherapy resistance of estrogen receptor-positive breast cancer (ER BC) by regulating aerobic glycolysis. The expression of PKM2 in ER BC MCF-7 cells, T47D cells and MCF-7/ADR cells (which are subject to adriamycin/ADR induction) were determined by quantitative real-time PCR and western blot. MCF-7/ADR (M/A) cells were grouped into blank group (M/A), negative group (M/A+NC), low expression of PKM2 group (M/A+si-PKM2 group), overexpression of PKM2 group (M/A+PKM2 group) and glycolysis inhibition group (M/A+PKM2+2-DG group)...
May 18, 2018: Anti-cancer Drugs
https://www.readbyqxmd.com/read/29782349/lncrna-malat-1-competitively-regulates-mir-124-to-promote-emt-and-development-of-non-small-cell-lung-cancer
#7
Jiasheng Wu, Yueyue Weng, Fei He, Dong Liang, Lin Cai
This study was carried out to explore the mechanism of LncRNA MALAT-1 as a competing endogenous RNA to regulate miR-124 in epithelial-mesenchymal transition and development of non-small-cell lung cancer (NSCLC). NSCLC and adjacent tissues were collected for RT-qPCR. The correlation of MALAT-1 and miR-124 was analyzed by Pearson. MALAT-1 expression was measured in NSCLC A549, NCI-H460, NCI-H529, SK-MES-1 cells, and 16HBE cells. A549 cells were selected for cell transfection experiments after the creation of six groups...
May 18, 2018: Anti-cancer Drugs
https://www.readbyqxmd.com/read/29782175/synthetic-insights-into-surface-functionalization-of-si-111-r-photoelectrodes-steric-control-and-deprotection-of-molecular-passivating-layers
#8
Ryan T Pekarek, Hugo Celio, Michael J Rose
We report the utility of controlled spacing of molecular monolayers on Si(111) surfaces by the use of sterically bulky silanes. The steric bulk of a 3,5-diphenolic linker of type Ph-diO-SiR3 (R = hexyl, phenyl, i Pr)-as well as the smaller Ph-diOMe-is shown to control the surface coverage on Si(111). The para substituent was also changed from -F (small) to -OTf (triflate, large) to modulate the conformation of a selected bulky silane (SiR3 ; R = hexyl) to further control the steric environment of the monolayer...
May 21, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29781637/a-comparison-of-several-approaches-for-controlling-measurement-error-in-small-samples
#9
Victoria Savalei
It is well known that methods that fail to account for measurement error in observed variables, such as regression and path analysis (PA), can result in poor estimates and incorrect inference. On the other hand, methods that fully account for measurement error, such as structural equation modeling with latent variables and multiple indicators, can produce highly variable estimates in small samples. This article advocates a family of intermediate models for small samples (N < 200), referred to as single indicator (SI) models...
May 21, 2018: Psychological Methods
https://www.readbyqxmd.com/read/29781566/the-5-ht7-receptor-is-up-regulated-in-onuf-s-nucleus-in-rats-with-chronic-spinal-cord-injury
#10
Jianshu Ni, Nailong Cao, Xiaohu Wang, Changsheng Zhan, Jiemin Si, Baojun Gu, Karl-Erik Andersson
OBJECTIVES: To examine the effect of intrathecal 5-HT7 agonist administration on voiding function in urethane-anesthetized rat, and the change of 5-HT7 receptor expression in lumbosacral cord Onuf's nucleus after SCI. MATERIALS AND METHODS: Thirty-two female Sprague-Dawley (SD) rats were divided into spinally intact (SI) group and SCI group (n=16 each). Eight weeks after transection, half of the rats underwent continuous cystometry under urethane anesthetization, and the 5-HT7 selective agonist LP44 was given intrathecally...
May 21, 2018: BJU International
https://www.readbyqxmd.com/read/29781562/il-6-triggers-the-migration-and-invasion-of-oestrogen-receptor-negative-breast-cancer-cells-via-regulation-of-hippo-pathways
#11
Lingmi Hou, Shaoli Xie, Guanwu Li, Bin Xiong, Yanchun Gao, Xiaobo Zhao, Jiani Hu, Shishan Deng, Jun Jiang
Breast cancer is one of the major challenges for women's health. However, the role and mechanisms of interleukins (ILs) on the progression of breast cancer are not well illustrated. Our present study revealed that the expression of IL-6 and IL-8 was significantly increased in oestrogen receptor negative (ER-) breast cancer cells. Increased expression of IL-6 was observed in 83.9% (26/31) ER- breast cancer tissues as compared with their matched adjacent normal tissues. In vitro studies indicated that IL-6 can significantly promote the migration and invasion of ER- breast cancer cells via increasing the dephosphorylation, nuclear translocation and transcriptional activities of YAP in breast cancer cells...
May 21, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29781387/estrogen-related-receptor-alpha-triggers-the-migration-and-invasion-of-endometrial-cancer-cells-via-up-regulation-of-tgfb1
#12
Xiumin Huang, Xuelian Wang, Jing Shang, Zhiqin Zhaang, Binbin Cui, Yanzhen Lin, Ying Yang, Youyi Song, Shengnan Yu, Junjie Xia
Estrogenic signals have been suggested to be important for the tumorigenesis and progression of endometrial cancer (EC) cells. Our present data showed that estrogen related receptor alpha (ERRα), while not ERRβ or ERRγ, was significantly elevated in EC cells and tissues when compared to their controls. Targeted inhibition of ERRα by siRNA or its inverse agonist XCT-790 can suppress the migration and invasion of EC cells. Both si-ERRα and XCT-790 decreased the expression of transforming growth factor-beta (TGF-β)...
May 21, 2018: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/29781318/hypochlorite-modified-albumins-promote-cell-death-in-the-tubule-interstitium-in-rats-via-mitochondrial-damage-in-obstructive-nephropathy-and-the-protective-effects-of-antioxidant-peptides
#13
Zong-Rui Liu, Si-Qi Chen, Yao-Wei Zou, Xiao-Yu Wu, Hong-Ying Li, Xiao-Qiao Wang, Yue Shi, Hong-Xin Niu
A major feature of the injury sustained by the kidney during obstructive nephropathy is a profound induction of apoptosis in the tubular epithelium. In this study, we explored the central roles of mitochondria and the mechanism of the protective effect of the mitochondrial targeted peptides in tubular cell apoptosis and interstitial fibrosis during obstructive nephropathy. Unilateral ureter obstruction (UUO) was performed on rats, and the animals were randomly assigned to intravenous treatment with normal saline, rat serum albumin (RSA), or HOCl-rat serum albumin (HOCl-RSA) in the presence or absence of SS-31...
May 2018: Free Radical Research
https://www.readbyqxmd.com/read/29781041/a-bead-based-immunogold-silver-staining-assay-on-capillary-driven-microfluidics
#14
Ngoc M Pham, Sebastian Rusch, Yuksel Temiz, Robert D Lovchik, Hans-Peter Beck, Walter Karlen, Emmanuel Delamarche
Point-of-care (POC) diagnostics are critically needed for the detection of infectious diseases, particularly in remote settings where accurate and appropriate diagnosis can save lives. However, it is difficult to implement immunoassays, and specifically immunoassays relying on signal amplification using silver staining, into POC diagnostic devices. Effective immobilization of antibodies in such devices is another challenge. Here, we present strategies for immobilizing capture antibodies (cAbs) in capillary-driven microfluidic chips and implementing a gold-catalyzed silver staining reaction...
May 21, 2018: Biomedical Microdevices
https://www.readbyqxmd.com/read/29780886/efficient-and-stable-silicon-microwire-photocathodes-with-a-nickel-silicide-interlayer-for-operation-in-strongly-alkaline-solutions
#15
Wouter Vijselaar, Roald M Tiggelaar, Han Gardeniers, Jurriaan Huskens
Most photoanodes commonly applied in solar fuel research (e.g., of Fe2 O3 , BiVO4 , TiO2 , or WO3 ) are only active and stable in alkaline electrolytes. Silicon (Si)-based photocathodes on the other hand are mainly studied under acidic conditions due to their instability in alkaline electrolytes. Here, we show that the in-diffusion of nickel into a 3D Si structure, upon thermal annealing, yields a thin (sub-100 nm), defect-free nickel silicide (NiSi) layer. This has allowed us to design and fabricate a Si microwire photocathode with a NiSi interlayer between the catalyst and the Si microwires...
May 11, 2018: ACS Energy Letters
https://www.readbyqxmd.com/read/29780566/nontrigonal-constraint-enhances-1-2-addition-reactivity-of-phosphazenes
#16
Yi-Chun Lin, James C Gilhula, Alexander T Radosevich
The syntheses and 1,2-addition reactivities of nontrigonal phosphazenes supported by trianionic tricoordinating chelates of the type L3 P 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 1111111111111111111111111111111111 1111111111111111111111111111111111 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 1111111111111111111111111111111111 1111111111111111111111111111111111 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 0000000000000000000000000000000000 Ndipp ( 3 : L3 = N[CHC( t Bu)O]2 3- ; 4 : L3 = N( o -NMeC6 H4 )2 3- ; dipp = 2,6-diisopropylphenyl) are reported...
May 14, 2018: Chemical Science
https://www.readbyqxmd.com/read/29780484/exploiting-the-interactions-between-the-ruthenium-hoveyda-grubbs-catalyst-and-al-modified-mesoporous-silica-the-case-of-sba15-vs-kcc-1
#17
Baraa Werghi, Eva Pump, Mykyta Tretiakov, Edy Abou-Hamad, Andrei Gurinov, Pradeep Doggali, Dalaver H Anjum, Luigi Cavallo, Anissa Bendjeriou-Sedjerari, Jean-Marie Basset
Immobilization of the 2nd generation Hoveyda-Grubbs catalyst HG-II onto well-ordered 2D hexagonal (SBA15) and 3D fibrous (KCC-1) mesostructured silica, which contained tetra-coordinated Al, has been investigated through the Surface Organometallic Chemistry (SOMC) methodology. The main interest of this study lies in the peculiarity of the silica supports, which display a well-defined tetrahedral aluminum hydride site displaying a strong Lewis acid character, [( 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 11111111111111111 11111111111111111 00000000000000000 00000000000000000 00000000000000000 00000000000000000 11111111111111111 11111111111111111 00000000000000000 00000000000000000 00000000000000000 00000000000000000 11111111111111111 11111111111111111 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 Si-O-Si 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 11111111111111111 11111111111111111 00000000000000000 00000000000000000 00000000000000000 00000000000000000 11111111111111111 11111111111111111 00000000000000000 00000000000000000 00000000000000000 00000000000000000 11111111111111111 11111111111111111 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 )( 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 11111111111111111 11111111111111111 00000000000000000 00000000000000000 00000000000000000 00000000000000000 11111111111111111 11111111111111111 00000000000000000 00000000000000000 00000000000000000 00000000000000000 11111111111111111 11111111111111111 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 Si-O-)2 Al-H]...
April 14, 2018: Chemical Science
https://www.readbyqxmd.com/read/29779778/identification-of-tb-e12-as-a-novel-ftsz-inhibitor-with-anti-tuberculosis-activity
#18
Yuan Lin, Hongjuan Zhang, Ningyu Zhu, Xia Wang, Yanxing Han, Minghua Chen, Jiandong Jiang, Shuyi Si
The global pandemic of multidrug-resistant (MDR) Mycobacterium tuberculosis (TB) drives for more effective anti-TB drugs with new drug target. Filamentous temperature sensitive protein Z (FtsZ), a GTP dependent prokaryotic cell division protein, forms a dynamic Z-ring in the center of the cell. Differences between bacterial FtsZ and eukaryotic tubulin make FtsZ a highly attractive drug target. In this study, we used phenotype screening of M. smegmatis and model screening targeting M. tuberculosis FtsZ (Mtb-FtsZ) to identify a hit compound TB-E12...
May 2018: Tuberculosis
https://www.readbyqxmd.com/read/29779309/-the-survival-prediction-model-of-advanced-gallbladder-cancer-based-on-bayesian-network-a-multi-institutional-study
#19
Z H Tang, Z M Geng, C Chen, S B Si, Z Q Cai, T Q Song, P Gong, L Jiang, Y H Qiu, Y He, W L Zhai, S P Li, Y C Zhang, Y Yang
Objective: To investigate the clinical value of Bayesian network in predicting survival of patients with advanced gallbladder cancer(GBC)who underwent curative intent surgery. Methods: The clinical data of patients with advanced GBC who underwent curative intent surgery in 9 institutions from January 2010 to December 2015 were analyzed retrospectively.A median survival time model based on a tree augmented naïve Bayes algorithm was established by Bayesia Lab software.The survival time, number of metastatic lymph nodes(NMLN), T stage, pathological grade, margin, jaundice, liver invasion, age, sex and tumor morphology were included in this model...
May 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29779288/-advances-in-surgical-techniques-of-periodontal-corticotomy
#20
Si-Yu Wang, Zhen-Dong Wang, Bin Yan
The number of adults seeking orthodontic treatment is increasing. Shortening the course of orthodontic treatment has become a research hotspot in recent years. Methods of accelerating tooth movement have been reported. Theoretical and clinical studies have confirmed that periodontal corticotomy is effective in accelerating tooth movement and increasing osteogenic potential. Many surgical techniques of periodontal corticotomy have been developed. This review summarizes the history of periodontal corticotomy and the development of the surgical techniques in recent years, thereby providing references for the clinical application of corticotomy...
April 1, 2018: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
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