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https://www.readbyqxmd.com/read/28221817/neuroprotective-effect-of-omega-3-polyunsaturated-fatty-acids-in-the-6-ohda-model-of-parkinson-s-disease-is-mediated-by-a-reduction-of-inducible-nitric-oxide-synthase
#1
Marco Aurélio Mori, Ana Marcia Delattre, Bruno Carabelli, Claudia Pudell, Mariza Bortolanza, Pedro Vinícius Staziaki, Jesuí Vergilio Visentainer, Paula Fernandes Montanher, Elaine A Del Bel, Anete Curte Ferraz
OBJECTIVE: Parkinson's disease (PD) is characterized by deterioration of the nigrostriatal system and associated with chronic neuroinflammation. Glial activation has been associated with regulating the survival of dopaminergic neurons and is thought to contribute to PD through the release of proinflammatory and neurotoxic factors, such as reactive nitric oxide (NO) that triggers or exacerbates neurodegeneration in PD. Polyunsaturated fatty acids (PUFAs) exert protective effects, including antiinflammatory, antiapoptotic, and antioxidant activity, and may be promising for delaying or preventing PD by attenuating neuroinflammation and preserving dopaminergic neurons...
February 21, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28220076/actions-and-mechanisms-of-polyunsaturated-fatty-acids-on-voltage-gated-ion-channels
#2
REVIEW
Fredrik Elinder, Sara I Liin
Polyunsaturated fatty acids (PUFAs) act on most ion channels, thereby having significant physiological and pharmacological effects. In this review we summarize data from numerous PUFAs on voltage-gated ion channels containing one or several voltage-sensor domains, such as voltage-gated sodium (NaV), potassium (KV), calcium (CaV), and proton (HV) channels, as well as calcium-activated potassium (KCa), and transient receptor potential (TRP) channels. Some effects of fatty acids appear to be channel specific, whereas others seem to be more general...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28220056/a-lipidomic-and-metabolomic-serum-signature-from-nonhuman-primates-exposed-to-ionizing-radiation
#3
Evan L Pannkuk, Evagelia C Laiakis, Tytus D Mak, Giuseppe Astarita, Simon Authier, Karen Wong, Albert J Fornace
INTRODUCTION: Due to dangers associated with potential accidents from nuclear energy and terrorist threats, there is a need for high-throughput biodosimetry to rapidly assess individual doses of radiation exposure. Lipidomics and metabolomics are becoming common tools for determining global signatures after disease or other physical insult and provide a "snapshot" of potential cellular damage. OBJECTIVES: The current study assesses changes in the nonhuman primate (NHP) serum lipidome and metabolome 7 days following exposure to ionizing radiation (IR)...
May 2016: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/28217940/dietary-omega-3-polyunsaturated-fatty-acids-induce-plasminogen-activator-activity-and-dna-damage-in-rabbit-spermatozoa
#4
A N Kokoli, S N Lavrentiadou, I A Zervos, M P Tsantarliotou, M P Georgiadis, E A Nikolaidis, N Botsoglou, C M Boscos, I A Taitzoglou
The aim of this study was to determine the effect(s) of dietary omega-3 polyunsaturated fatty acids (ω-3 PUFA) on rabbit semen. Adult rabbit bucks were assigned to two groups that were given two diets, a standard diet (control) and a diet supplemented with ω-3 PUFA. Sperm samples were collected from all bucks with the use of an artificial vagina in 20-day intervals, for a total period of 120 days. The enrichment of membranes in ω-3 PUFA was manifested by the elevation of the 22:5 ω-3 (docosapentaenoic acid [DPA]) levels within 40 days...
February 20, 2017: Andrologia
https://www.readbyqxmd.com/read/28216642/high-fat-meal-systemic-inflammation-and-glucose-homeostasis-in-obese-children-and-adolescents
#5
A Morandi, E Fornari, F Opri, M Corradi, M Tommasi, R Bonadonna, C Maffeis
We aimed to assess in obese youths the relationships between interleukin 6 (IL-6), fat-meal induced endotoxemia and glucose homeostasis. Twenty obese children/adolescents (9-17 years old, 11 boys) underwent a standard OGTT and, 7-14 days later, a 5-hour fat meal test (fat=69% of energy, SFA/MUFA/PUFA=31.5%/35%/33.5%), with serial measures of IL-6 and two markers of lipopolysaccharide (LPS) exposure and translocation, LPS-binding protein (LBP) and soluble CD14 (sCD14). IL-6 correlated not only with basal (HOMA-IR) but also with post-prandial (Matsuda-index) insulin sensitivity (r=0...
February 20, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28215784/comparison-of-derivatization-ionization-techniques-for-liquid-chromatography-tandem-mass-spectrometry-analysis-of-oxylipins
#6
Sven W Meckelmann, Stefan Hellhake, Maryvonne Steuck, Michael Krohn, Nils Helge Schebb
The performance of two derivatization and ionization techniques for the quantitative reversed phase liquid chromatography (LC)- mass spectrometry (MS) analysis of hydroxy fatty acids (OH-PUFA) in plasma was evaluated: One used AMPP (N-(4-aminomethylphenyl)pyridinium chloride) leading to a positive charged amid-derivate which can be detected by electrospray ionization (ESI)-MS. Second yielded penta fluorobenzyl bromide (PFB) ester derivates allowing detection in electron capture atmospheric pressure chemical ionization (ecAPCI)-MS...
February 16, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28213537/ketoacylsynthase-domains-of-a-pufa-synthase-in-thraustochytrium-can-effectively-function-as-stand-alone-enzymes-in-escherichia-coli
#7
Xi Xie, Dauenpen Meesapyodsuk, Xiao Qiu
Thraustochytrium sp. 26185 accumulates a high level of docosahexaenoic acid (DHA), a nutritionally important ω-3 very long chain unsaturated fatty acid (VLCPUFA) synthesized primarily by polyunsaturated fatty acid (PUFA) synthase, a Type I polyketide synthase-like mega-enzyme. The PUFA synthase in this species comprises three large subunits each with multiple catalytic domains. It was hypothesized that among these domains, ketoacylsynthase (KS) domains might be critical for catalyzing the condensation of specific unsaturated acyl-ACPs with malonyl-ACP, whereby retaining double bonds in an extended acyl chain...
February 17, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28211551/eating-habits-and-the-risk-of-cardiovascular-disease-in-patients-with-recurrent-depressive-disorders
#8
Ewa Stefańska, Agnieszka Wendołowicz, Urszula Cwalina, Beata Konarzewska, Napoleon Waszkiewicz, Lucyna Ostrowska
OBJECTIVES: The aim of the research was to assess the fatty acid content and atherogenicity of daily food rations in patients with recurrent depressive disorders in the aspect of risk of developing cardiovascular disease. METHODS: The study included 126 persons (62 persons with diagnosed recurrent depressive disorders and 64 healthy volunteers). A 24-hour recall was used in the quantitative assessment of the diet. Anthropometric and chemical measurements as well as body composition analysis were used to assess the nutritional status...
December 23, 2016: Psychiatria Polska
https://www.readbyqxmd.com/read/28210754/targeted-lipidomics-profiling-of-acute-arsenic-exposure-in-mice-serum-by-on-line-solid-phase-extraction-stable-isotope-dilution-liquid-chromatography-tandem-mass-spectrometry
#9
Chao-Yu Chen, Pinpin Lin, Ming-Hsien Tsai, Hui-Ling Lee
Lipidomics is the area of study dedicated to the comprehensive analysis and characterization of the functions and metabolism of lipids in biological samples. One of the most comprehensively studied classes of lipids is polyunsaturated fatty acids (PUFAs). Eicosanoids are a series of bioactive lipid mediators that are metabolized from PUFAs and generated majorly from the precursor arachidonic acid. This study identified the profiles of target eicosanoids after acute exposure to arsenic. The principle objective was to determine and validate 10 eicosanoids in mouse serum using on-line solid-phase extraction integrated with liquid chromatography-electrospray tandem mass spectrometry...
February 16, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28208667/dietary-fatty-acids-and-changes-in-blood-lipids-during-adolescence-the-role-of-substituting-nutrient-intakes
#10
Carla Harris, Anette Buyken, Sibylle Koletzko, Andrea von Berg, Dietrich Berdel, Tamara Schikowski, Berthold Koletzko, Joachim Heinrich, Marie Standl
The relevance of dietary fatty acids (FA) for blood lipids should be assessed in the context of substituting nutrients. Such evidence is lacking for adolescents. This study describes prospective associations of dietary FA with changes in serum lipids during adolescence, and considers the theoretical isocaloric replacements of saturated FA (SFA) with other FA or carbohydrates (CHO). Children from the GINIplus and LISAplus birth cohorts, with data on FA intakes (at age 10 years) and serum lipids (at age 10 and 15 years), were included (n = 1398)...
February 11, 2017: Nutrients
https://www.readbyqxmd.com/read/28207502/impact-of-the-dietary-fatty-acid-intake-on-c-reactive-protein-levels-in-us-adults
#11
Mohsen Mazidi, Hong-Kai Gao, Hassan Vatanparast, Andre Pascal Kengne
Growing evidence suggests that the effects of diet on cardiovascular disease (CVD) occur through mechanisms involving subclinical inflammation. We assessed whether reported dietary fatty acid intake correlates with a serum high-sensitivity C-reactive protein (hs-CRP) concentration in a population-based sample of US men and women.In this cross-sectional analysis, participants were selected from the US National Health and Nutrition Examination Survey (NHANES) and restricted to those with available data on dietary intake, biochemical and anthropometric measurements from 2001 to 2010...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28205317/oxidative-stress-and-immunosenescence-in-spleen-of-obese-mice-can-be-reversed-by-2-hydroxyoleic-acid
#12
Alina Gheorghe, Fátima Pérez de Heredia, Caroline Hunsche, Noemí Redondo, Ligia Esperanza Díaz, Oskarina Hernández, Ascensión Marcos, Mónica De la Fuente
We aimed to investigate the effects of obesity on oxidative stress and leukocyte function in spleen of mice, and to assess whether supplementation with 2-hydroxyoleic acid (2-OHOA) or n-3 polyunsaturated fatty acids (PUFA) could reverse those effects. Female ICR/CD1 mice (8 weeks old, n = 24) received an obesogenic diet (22% fat for 4 weeks and 60% fat for 14 weeks). After 6 weeks, mice were split in three groups (n = 8/group): no supplementation, 2-OHOA supplementation (1500 mg kg(-1) ) and n-3 PUFA supplementation (EPA + DHA, 3000 mg kg(-1) diet)...
February 15, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28202633/regional-changes-in-cns-and-retinal-glycerophospholipid-profiles-with-age-a-molecular-blueprint
#13
Blake R Hopiavuori, Martin-Paul Agbaga, Richard S Brush, Michael T Sullivan, William E Sonntag, Robert E Anderson
We present herein a quantitative molecular blueprint of the three major glycerophospholipid (GPL) classes phosphatidylcholine (PC), phosphatidylserine (PS), and phosphatidylethanolamine (PE) in retina and six regions of the brain in C57Bl6 mice at 2, 10, and 26 months of age. We found an age-related increase in molecular species containing saturated and monoenoic fatty acids and an overall decrease in the longer chain polyunsaturated fatty acid (PUFA) molecular species across brain regions, with loss of docosahexaenoic acid (DHA)-containing molecular species as the most consistent and dramatic finding...
February 15, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28198164/influence-of-maternal-and-socioeconomic-factors-on-breast-milk-fatty-acid-composition-in-urban-low-income-families
#14
Uma Nayak, Suman Kanungo, Dadong Zhang, E Ross Colgate, Marya P Carmolli, Ayan Dey, Masud Alam, Byomkesh Manna, Ranjan Kumar Nandy, Deok Ryun Kim, Dilip Kumar Paul, Saugato Choudhury, Sushama Sahoo, William S Harris, Thomas F Wierzba, Tahmeed Ahmed, Beth D Kirkpatrick, Rashidul Haque, William A Petri, Josyf C Mychaleckyj
The lipid composition of breast milk may have a significant impact on early infant growth and cognitive development. Comprehensive breast milk data is lacking from low-income populations in the Indian subcontinent impeding assessment of deficiencies and limiting development of maternal nutritional interventions. A single breast milk specimen was collected within 6 weeks postpartum from two low-income maternal cohorts of exclusively breastfed infants, from Dhaka, Bangladesh (n = 683) and Kolkata, India (n = 372) and assayed for percentage composition of 26 fatty acids...
February 15, 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28194404/a-note-on-fatty-acids-profile-of-meat-from-broiler-chickens-supplemented-with-inorganic-or-organic-selenium
#15
Marta Del Puerto, M Cristina Cabrera, Ali Saadoun
This investigation evaluated, in broiler chickens Pectoralis and Gastrocnemius muscles, the effect of the dietary supplementation with sodium selenite (0.3 ppm) versus selenomethionine (0.3 ppm), on the fatty acids composition, lipids indices, and enzymes indexes for desaturase, elongase, and thioesterase. The selenium reduced, in both muscles, the content of atherogenic fatty acids, C14:0 and C16:0, while it increased the C18:1 level. On the other hand, selenium increased, in both muscles, the content of C18:3n3 and EPA, but not DPA and DHA...
2017: International journal of food science
https://www.readbyqxmd.com/read/28192538/pattern-of-omega-3-polyunsaturated-fatty-acid-intake-and-fish-consumption-and-retinal-vascular-caliber-in-children-and-adolescents-a-cohort-study
#16
Bamini Gopinath, Hanieh Moshtaghian, Victoria M Flood, Jimmy C Y Louie, Gerald Liew, George Burlutsky, Paul Mitchell
We aimed to investigate whether fish and long chain omega-3 polyunsaturated fatty acid (LCn-3 PUFA) consumption changed appreciably during adolescence. We also assessed whether these dietary variables are associated with retinal microvascular signs (possible markers of future cardiovascular disease risk). 633 children had dietary data at ages 12 and 17. Fish and LCn-3 PUFA [eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA)] intake was assessed by a food frequency questionnaire...
2017: PloS One
https://www.readbyqxmd.com/read/28185952/region-specific-vulnerability-to-lipid-peroxidation-and-evidence-of-neuronal-mechanisms-for-polyunsaturated-fatty-acid-biosynthesis-in-the-healthy-adult-human-central-nervous-system
#17
Alba Naudí, Rosanna Cabré, Mayelin Dominguez-Gonzalez, Victoria Ayala, Mariona Jové, Natalia Mota-Martorell, Gerard Piñol-Ripoll, Maria Pilar Gil-Villar, Montserrat Rué, Manuel Portero-Otín, Isidre Ferrer, Reinald Pamplona
Lipids played a determinant role in the evolution of the brain. It is postulated that the morphological and functional diversity among neural cells of the human central nervous system (CNS) is projected and achieved through the expression of particular lipid profiles. The present study was designed to evaluate the differential vulnerability to oxidative stress mediated by lipids through a cross-regional comparative approach. To this end, we compared 12 different regions of CNS of healthy adult subjects, and the fatty acid profile and vulnerability to lipid peroxidation, were determined by gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS), respectively...
February 7, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28183305/controlling-of-growth-performance-lipid-deposits-and-fatty-acid-composition-of-chicken-meat-through-a-probiotic-lactobacillus-johnsonii-during-subclinical-clostridium-perfringens-infection
#18
Hesong Wang, Xueqin Ni, Lei Liu, Dong Zeng, Jing Lai, Xiaodan Qing, Guangyao Li, Kangcheng Pan, Bo Jing
BACKGROUND: Meat is considered as a major source of polyunsaturated fatty acid (PUFA) which is essential for humans, therefore its lipid level and fatty acid composition have drawn great attention. As no clinical sign can be found in chicks subclinically infected by Clostridium perfringens (CP), the meat may be purchased and eaten. The objective of the present study was to determine whether Lactobacillus johnsonii (LJ) can control the CP-caused impact on growth, lipid levels, fatty acid composition and other flavor or nutritional quality in the meat...
February 10, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28183054/national-estimation-of-seafood-consumption-in-mexico-implications-for-exposure-to-methylmercury-and-polyunsaturated-fatty-acids
#19
Alejandra Cantoral, Carolina Batis, Niladri Basu
BACKGROUND: Seafood is a good source of Omega-3 polyunsaturated fatty acids (ω3-PUFA) but also contains the toxic contaminant methylmercury (MeHg). National estimates of exposure to both compounds through seafood intake in Mexico are not known. The objective of the current study was to describe national seafood consumption habits and to estimate seafood-based exposure to ω3-PUFAs and MeHg. METHODS: We analyzed data from a 24-h dietary recall extracted from the 2012 National Health and Nutrition Survey of Mexico (n = 10,096 subjects aged 1y and older)...
January 26, 2017: Chemosphere
https://www.readbyqxmd.com/read/28182843/inhibitory-effects-of-red-wine-on-lipid-oxidation-in-fish-oil-emulsion-and-angiogenesis-in-zebrafish-embryo
#20
Haiyan Sun, Yulin Zhang, Yixiao Shen, Yongchao Zhu, Hua Wang, Zhimin Xu
The capabilities of red wine against lipid oxidation and angiogenesis were evaluated by using a fish oil emulsion system and an in vivo zebrafish embryos model, respectively. The red wine contained 12 different antioxidant phenolics which levels were led by anthocyanins (140.46 mg/L), catechin (55.08 mg/L), and gallic acid (46.76 mg/L). The diversity of the phenolics in red wine was greater than the tea, coffee, or white wine selected as a peer control in this study. The total phenolics concentration of red wine was 305...
February 9, 2017: Journal of Food Science
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