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https://www.readbyqxmd.com/read/29453672/the-effect-of-n-3-pufas-on-circulating-adiponectin-and-leptin-in-patients-with-type-2-diabetes-mellitus-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#1
Azam Rezaei Farimani, Mitra Hariri, Mohsen Azimi-Nezhad, Abasalt Borji, Sadegh Zarei, Elham Hooshmand
AIM: N-3 PUFAs can potentially influence levels of inflammatory and non-inflammatory adipokines. Given the contradictory effects of n-3 PUFAs on serum levels of adipokines in type 2 diabetes, we conducted a systematic review and meta-analysis study of randomized placebo-controlled clinical trials that examined the effects of n-3 PUFAs on serum levels of leptin and adiponectin in patients with type 2 diabetes. METHODS: The electronic databases, without regard to language restrictions including PubMed/Medline, Google Scholar, SCOPUS and ISI Web of Science until August 2017, were used to identify randomized controlled trials that assessed the effect of n-3 PUFAs on serum leptin and adiponectin concentrations in type 2 diabetes...
February 16, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29452596/relationship-between-polyunsaturated-fatty-acid-composition-in-serum-phospholipids-systemic-low-grade-inflammation-and-glycemic-control-in-patients-with-type-2-diabetes-and-atherosclerotic-cardiovascular-disease
#2
Malgorzata Poreba, Pawel Rostoff, Aleksander Siniarski, Magdalena Mostowik, Renata Golebiowska-Wiatrak, Jadwiga Nessler, Anetta Undas, Grzegorz Gajos
BACKGROUND: There are inconsistent data about the role of serum phospholipid fatty acid composition in patients with type 2 diabetes (T2DM) and atherosclerotic cardiovascular disease (ASCVD). The aim of the study was to investigate the relationship between serum phospholipid fatty acid composition, systemic low-grade inflammation, and glycemic control in high-risk T2DM patients. METHODS: Seventy-four patients (26% women, mean age 65.6 ± 6.8 years) with T2DM (median diabetes duration 10 years) and documented ASCVD (74 with coronary artery disease, 26 with peripheral arterial disease) were enrolled in the study...
February 16, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29452256/modulation-of-oxidative-stress-response-by-flaxseed-oil-role-of-lipid-peroxidation-and-underlying-mechanisms
#3
REVIEW
Rajnish Kumar Yadav, Manjari Singh, Subhadeep Roy, Mohd Nazam Ansari, Abdulaziz S Saeedan, Gaurav Kaithwas
Polyunsaturated fatty acids (PUFA's) are majorly classified as ω-3 and ω-6 fatty acids. The eicosapentaenoic acid (EPA, ω-3:20-5), docosahexaenoic acid (DHA, ω-3:22-6) and alpha-linolenic acid (ALA, ω-3:18-3) are known ω-3 fatty acids, extracted from animal (e.g fish oil) and plant sources (e.g flaxseed oil). Furthermore, linoleic acid (LA, ω-6:18-2) is recognized as ω-6 fatty acid and the most prominent biological fatty acid with a pro-inflammatory response. Flaxseed oil has variety of biological roles, due to a significant amount of ω-3/ω-6 fatty acids...
February 13, 2018: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/29450735/n-acetyl-l-cysteine-protects-dental-tissue-stem-cells-against-oxidative-stress-in-vitro
#4
Jasmina Martacic, Milica Kovacevic Filipovic, Suncica Borozan, Zorica Cvetkovic, Tamara Popovic, Aleksandra Arsic, Marija Takic, Vesna Vucic, Maria Glibetic
OBJECTIVES: The aim of our study was to investigate whether N-acetyl-L-cysteine (NAC) could protect stem cells from exfoliated deciduous teeth (SHED) against oxidative damage, during in vitro cultivation, to preserve regenerative potential of these cells. Accordingly, we examined the potential of cell culture supplementation with NAC in prevention of lipid peroxidation, unfavorable changes of total lipids fatty acid composition, and the effects on the activity of antioxidant enzymes. MATERIAL AND METHODS: We analyzed the extent of oxidative damage in SHED after 48 h treatment with different NAC concentrations...
February 15, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29438460/practical-dietary-recommendations-for-the-prevention-and-management-of-nonalcoholic-fatty-liver-disease-in-adults
#5
Elena S George, Adrienne Forsyth, Catherine Itsiopoulos, Amanda J Nicoll, Marno Ryan, Siddharth Sood, Stuart K Roberts, Audrey C Tierney
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide. In the absence of effective pharmacotherapies, clinical guidelines focus primarily on weight loss to treat this condition. Established consensus, evidence-based, and clinical dietary recommendations for NAFLD are currently lacking. The aim of this paper is to provide evidence-based practical dietary recommendations for the prevention and management of NAFLD in adults. A literature review focusing on established principles for the development of clinical practice recommendations was employed using the following criteria: based on substantial evidence, ensures risk minimization, is flexible for an individual patient approach, and is open to further modification as evidence emerges...
January 1, 2018: Advances in Nutrition
https://www.readbyqxmd.com/read/29436695/inhibition-of-mammalian-target-of-rapamycin-complex-1-signaling-by-n-3-polyunsaturated-fatty-acids-promotes-locomotor-recovery-after-spinal-cord-injury
#6
Jiping Nie, Jian Chen, Jianguo Yang, Qinqin Pei, Jing Li, Jia Liu, Lixin Xu, Nan Li, Youhao Chen, Xiaohua Chen, Hao Luo, Tiansheng Sun
The present study aimed to explore the effects of n‑3 polyunsaturated fatty acids (PUFAs) on autophagy and their potential for promoting locomotor recovery after spinal cord injury (SCI). Primary neurons were isolated and cultured. Sprague‑Dawley rats were randomly divided into three groups and fed diets with different amounts of n‑3 PUFAs. A model of spinal cord contusion was created at the T10 spinal segment and the composition of PUFAs was analyzed using gas chromatography. Spinal repair and motor function were evaluated postoperatively...
February 8, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29436473/high-erythrocyte-levels-of-the-n-6-polyunsaturated-fatty-acid-linoleic-acid-are-associated-with-lower-risk-of-subsequent-rheumatoid-arthritis-in-a-southern-european-nested-case-control-study
#7
Paola de Pablo, Dora Romaguera, Helena L Fisk, Philip C Calder, Anne-Marie Quirke, Alison J Cartwright, Salvatore Panico, Amalia Mattiello, Diana Gavrila, Carman Navarro, Carlotta Sacerdote, Paolo Vineis, Rosario Tumino, William E Ollier, Dominique S Michaud, Elio Riboli, Patrick J Venables, Benjamin A Fisher
OBJECTIVES: Findings relating to dietary intake of n-3 polyunsaturated fatty acids (PUFA) and risk of rheumatoid arthritis (RA) are mixed. Erythrocyte membrane PUFA is an accurate objective biomarker of PUFA status; however, there are little data on erythrocyte membrane PUFA and risk of RA. The objective was therefore to compare erythrocyte membrane PUFA between pre-RA individuals and matched controls from a population-based sample, and specifically to test the hypothesis that higher levels of longer chain n-3 PUFA are associated with lower risk of RA...
February 7, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29434704/implications-of-dietary-%C3%AF-3-and-%C3%AF-6-polyunsaturated-fatty-acids-in-breast-cancer
#8
Oana Zanoaga, Ancuta Jurj, Lajos Raduly, Roxana Cojocneanu-Petric, Enrique Fuentes-Mattei, Oscar Wu, Cornelia Braicu, Claudia Diana Gherman, Ioana Berindan-Neagoe
Breast cancer represents one of the most common forms of cancer in women worldwide, with an increase in the number of newly diagnosed patients in the last decade. The role of fatty acids, particularly of a diet rich in ω-3 and ω-6 polyunsaturated fatty acids (PUFAs), in breast cancer development is not fully understood and remains controversial due to their complex mechanism of action. However, a large number of animal models and cell culture studies have demonstrated that high levels of ω-3 PUFAs have an inhibitory role in the development and progression of breast cancer, compared to ω-6 PUFAs...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29433780/nutritional-enhancement-of-sheep-meat-fatty-acid-profile-for-human-health-and-wellbeing
#9
Obert C Chikwanha, Payam Vahmani, Voster Muchenje, Michael E R Dugan, Cletos Mapiye
Dietary fatty acids (FA) consumed by sheep, like other ruminants, can undergo biohydrogenation resulting in high proportions of saturated FA (SFA) in meat. Biohydrogenation is typically less extensive in sheep than cattle, and consequently, sheep meat can contain higher proportions of omega (n)-3 polyunsaturated FA (PUFA), and PUFA biohydrogenation intermediates (PUFA-BHI) including conjugated linoleic acid (CLA) and trans-monounsaturated FAs (t-MUFA). Sheep meat is also noted for having characteristically higher contents of branched chain FA (BCFA)...
February 2018: Food Research International
https://www.readbyqxmd.com/read/29433574/association-between-diet-quality-dietary-patterns-and-cardiometabolic-health-in-australian-adults-a-cross-sectional-study
#10
Katherine M Livingstone, Sarah A McNaughton
BACKGROUND: Diet quality indices score dietary intakes against recommendations, whereas dietary patterns consider the pattern and combination of dietary intakes. Studies evaluating both methodologies in relation to cardiometabolic health in a nationally representative sample are limited. The aim of the present study was to investigate the relationship between diet quality, dietary patterns and markers of cardiometabolic health in Australian adults. METHODS: Dietary data, using two 24-h dietary recalls, were collected from adults in the cross-sectional Australian Health Survey 2011-2013 (n = 2121; 46...
February 12, 2018: Nutrition Journal
https://www.readbyqxmd.com/read/29433225/metabolite-profiling-of-green-green-red-and-red-lettuce-cultivars-variation-in-health-beneficial-compounds-and-antioxidant-potential
#11
Dae-Eun Kim, Xiaomin Shang, Awraris Derbie Assefa, Young-Soo Keum, Ramesh Kumar Saini
Salad vegetables, commonly consumed at baby-leaf stages, are the most appropriate and emerging dietary source of antioxidant compounds. Screening and identification of nutrient-rich cultivars can be potentially useful to obtain a nutrient-dense diet. Thus, in this study, we explored the genetic potential of baby leaves of 23 diverse lettuce cultivars for the health-beneficial metabolites. The results showed that the composition and contents of the studied metabolites in lettuces varied significantly between cultivars and were principally dependent on leaf color...
March 2018: Food Research International
https://www.readbyqxmd.com/read/29433209/effect-of-hop-%C3%AE-acids-as-dietary-supplement-for-broiler-chickens-on-meat-composition-and-redox-stability
#12
A Zawadzki, C Alloo, A B Grossi, E S P do Nascimento, L C Almeida, S Bogusz Junior, L H Skibsted, D R Cardoso
Addition of β-acids extracted from hop at different levels (0, 30mgkg-1, 60mgkg-1, 240mgkg-1) to the diet of broiler chickens demonstrated significant effects on the average concentration of polar metabolites and fatty acids of relevance for meat quality. The largest metabolic differences between control group and chicken fed different levels of β-acids were achieved using 30mgkg-1 of supplement. As determined by EPR spin-trapping, increased redox stability was also obtained for meat from chicken fed 30mgkg-1 of β-acids which also had highest level of endogenous antioxidants, especially anserine, carnosine, NADH and PUFAs...
March 2018: Food Research International
https://www.readbyqxmd.com/read/29430648/effect-of-castration-and-carcass-suspension-method-on-the-quality-and-fatty-acid-profile-of-beef-from-male-dairy-cattle
#13
Yingqun Nian, Paul Allen, Sabine M Harrison, Joseph P Kerry
BACKGROUND: The use of bulls rather than steers for beef production offers some considerable advantages, however, the eating quality of bull beef is an issue of marketing concern. This study assessed the physico-chemical characteristics of young Holstein-Friesian (HF) bull and steer beef. Steer carcasses were suspended by the Achilles tendon (AS) and by Pelvic suspension (PS). RESULTS: HF Steer beef had higher redness, yellowness, and chroma values, while bulls had higher ultimate pH and darker muscle...
February 12, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29428619/effect-of-dietary-n-3-polyunsaturated-fatty-acid-rich-fish-oil-on-the-endometrial-prostaglandin-production-in-the-doe-capra-hircus
#14
Ravjibhai K Chaudhari, Ajit Singh Mahla, Amit Kumar Singh, Sanjay Kumar Singh, Abhijit M Pawde, G V P P S Ravi Kumar, GyanendraSingh, Mihir Sarkar, Harendra Kumar, Krishnaswamy Narayanan
Recently, we showed that dietary supplementation of n-3 PUFA rich fish oil (FO) decreased the metabolites of serum prostaglandin (PG) F 2α and E 2 during the window of pregnancy recognition in the doe. In this study, we investigated its effect on the changes on endometrial PG production in vitro. Cycling does (n = 12) of Rohilkhand region were divided into two equal groups and fed a concentrate diet supplemented with either FO containing 26% n-3 PUFA (TRT; n = 6) or palm oil (CON; n = 6) @ 0.6 mL/kg body weight for 57 days...
February 8, 2018: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/29426414/a-critical-assessment-of-transmethylation-procedures-for-n-3-long-chain-polyunsaturated-fatty-acid-quantification-of-lipid-classes
#15
Anthony Sehl, Leslie Couëdelo, Laurence Fonseca, Carole Vaysse, Maud Cansell
Lipid transmethylation methods described in the literature are not always evaluated with care so to insure that the methods are effective, especially on food matrix or biological samples containing polyunsaturated fatty acid (PUFA). The aim of the present study was to select a method suitable for all lipid species rich in long chain n-3 PUFA. Three published methods were adapted and applied on individual lipid classes. Lipid (trans)methylation efficiency was characterized in terms of reaction yield and gas chromatography (GC) analysis...
June 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29425187/the-differential-effects-of-eicosapentaenoic-acid-and-docosahexaenoic-acid-on-cardiometabolic-risk-factors-a-systematic-review
#16
REVIEW
Jacqueline K Innes, Philip C Calder
A large body of evidence supports the cardioprotective effects of the long-chain omega-3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). There is increasing interest in the independent effects of EPA and DHA in the modulation of cardiometabolic risk factors. This systematic review aims to appraise the latest available evidence of the differential effects of EPA and DHA on such risk factors. A systematic literature review was conducted up to May 2017. Randomised controlled trials were included if they met strict eligibility criteria, including EPA or DHA > 2 g/day and purity ≥ 90%...
February 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29423508/association-of-retinopathy-of-prematurity-with-low-levels-of-arachidonic-acid-a-secondary-analysis-of-a-randomized-clinical-trial
#17
Chatarina A Löfqvist, Svetlana Najm, Gunnel Hellgren, Eva Engström, Karin Sävman, Anders K Nilsson, Mats X Andersson, Anna-Lena Hård, Lois E H Smith, Ann Hellström
Importance: Mice with oxygen-induced retinopathy fed matched diets except for ω-3 long-chain polyunsaturated fatty acids (LC-PUFAs) vs ω-6 LC-PUFAs demonstrate relative antiangiogenic and neuroprotective associations of ω-3 LC-PUFAs. However, supplementing preterm infants with LC-PUFAs has been inconsistent in reducing major preterm morbidities. However, few studies measured serum lipid levels after supplementation. Objective: To examine the associated risk of retinopathy of prematurity (ROP) from the levels of circulating ω-3 and ω-6 LC-PUFAs...
February 8, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29423386/erythrocyte-membrane-unsaturated-mono-and-poly-fatty-acids-profile-in-newly-diagnosed-basal-cell-carcinoma-patients
#18
Fatemeh Rahrovani, Mohammad Hassan Javanbakht, Ehsan Ghaedi, Hamed Mohammadi, Amir-Hooshang Ehsani, Ali Esrafili, Mahmoud Djalali
Studies have reported different changes in the fatty acid composition of red blood cell (RBC) total lipids in patients with various types of cancer. It has been indicated that n-3/n-6 ratio plays a key role in the general consequence of skin photocarcinogenesis. However, to our knowledge there was no study examining the unsaturated fatty acid profile in basal cell carcinoma (BCC) patients. So, we explore the fatty acid composition of RBCs in newly diagnosed BCC patients in a hospital-based case-control study...
January 2018: Clinical Nutrition Research
https://www.readbyqxmd.com/read/29422481/investigation-of-adipose-tissue-fatty-acid-composition-in-men-with-uronephrolithiasis-and-metabolic-syndrome
#19
Inga Bikulčienė, Laima Vasiliauskaitė, Zita Aušrelė Kučinskienė, Arvydas Kaminskas, Vaiva Hendrixson
BACKGROUND Fatty acids (FA) and their metabolites are closely related to some mechanisms involved in the development of uronephrolithiasis. The aim of this study was to evaluate the relationship between FA composition and type of kidney stones. MATERIAL AND METHODS Abdominal adipose tissue fatty acid methyl esters of 71 men with nephrolithiasis were identified by GC/MS, and the type of kidney stones was identified using FTIR infrared spectroscopy. Patients were divided into groups according to diagnosis of metabolic syndrome (MS) and type of kidney stone...
February 9, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29417145/stargardt-phenotype-associated-with-two-elovl4-promoter-variants-and-elovl4-downregulation-new-possible-perspective-to-etiopathogenesis
#20
Luigi Donato, Concetta Scimone, Carmela Rinaldi, Pasquale Aragona, Silvana Briuglia, Angela D'Ascola, Rosalia D'Angelo, Antonina Sidoti
Purpose: Stargardt disease (STGD) is the most common form of inherited juvenile macular degeneration. It is inherited as autosomal recessive trait (STGD1), although STGD3 and STGD4 are inherited as autosomal dominant inheritance pattern. STGD3 is caused by mutations in the elongation of very long-chain fatty acids-like 4 (ELOVL4) gene encoding for a very long-chain fatty acid elongase. Mutations lead to a truncated Elovl4, lacking of a dilysine motif necessary for retention of transmembrane proteins in the endoplasmic reticulum...
February 1, 2018: Investigative Ophthalmology & Visual Science
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