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Cardiac Mri scar

John Whitaker, Cory M Tschabrunn, Jihye Jang, Eran Leshem, Mark O'Neill, Warren J Manning, Elad Anter, Reza Nezafat
BACKGROUND: Myocardial infarction (MI) survivors are at risk of complications including heart failure and malignant arrhythmias. PURPOSE: We undertook serial imaging of swine following MI with the aim of characterizing the longitudinal left ventricular (LV) remodeling in a translational model of ischemia-reperfusion-mediated MI. ANIMAL MODEL: Eight Yorkshire swine underwent mid left anterior descending coronary artery balloon occlusion to create an ischemia-reperfusion experimental model of MI...
March 9, 2018: Journal of Magnetic Resonance Imaging: JMRI
Guang Yang, Xiahai Zhuang, Habib Khan, Shouvik Haldar, Eva Nyktari, Lei Li, Ricardo Wage, Xujiong Ye, Greg Slabaugh, Raad Mohiaddin, Tom Wong, Jennifer Keegan, David Firmin
PURPOSE: Atrial fibrillation (AF) is the most common heart rhythm disorder and causes considerable morbidity and mortality, resulting in a large public health burden that is increasing as the population ages. It is associated with atrial fibrosis, the amount and distribution of which can be used to stratify patients and to guide subsequent electrophysiology ablation treatment. Atrial fibrosis may be assessed non-invasively using late gadolinium-enhanced (LGE) magnetic resonance imaging (MRI) where scar tissue is visualised as a region of signal enhancement...
February 26, 2018: Medical Physics
Haining Liu, Gregory J Wilson, Niranjan Balu, Jeffrey H Maki, Daniel S Hippe, Wei Wu, Hiroko Watase, Jinnan Wang, Martin L Gunn, Chun Yuan
OBJECTIVES: A postprocessing technique termed 3D true-phase polarity recovery with independent phase estimation using three-tier stacks based region growing (3D-TRIPS) was developed, which directly reconstructs phase-sensitive inversion-recovery images without acquisition of phase-reference images. The utility of this technique is demonstrated in myocardial late gadolinium enhancement (LGE) imaging. MATERIALS AND METHODS: A data structure with three tiers of stacks was used for 3D-TRIPS to directly achieve reliable region growing for successful background-phase estimation...
February 2018: Magma
Maryam Nezafat, Isabel T Ramos, Markus Henningsson, Andrea Protti, Tamer Basha, René M Botnar
OBJECT: To develop and evaluate a 2D modified Look-Locker (MOLLI) for high-resolution T1 mapping in mice using a 3T MRI scanner. MATERIALS AND METHODS: To allow high-resolution T1 mapping in mice at high heart rates a multi-shot ECG-triggered 2D MOLLI sequence was developed. In the proposed T1 mapping sequence the optimal number of sampling points and pause cardiac cycles following an initial adiabatic inversion pulse was investigated in a phantom. Seven native control and eight mice, 3 days post myocardial infarction (MI) after administration of gadolinium were scanned...
2017: PloS One
Sarah Nordmeyer, Boris Schmitt, Boris Nasseri, Vladimir Alexi-Meskishvili, Titus Kuehne, Felix Berger, Johannes Nordmeyer
BACKGROUND: We sought to assess left ventricular regional function in patients with and without left ventricular wall scar tissue in the long term after repair of an anomalous origin of the left coronary artery from the pulmonary artery. METHODS: A total of 20 patients aged 12.8±7.4 years were assessed 10 (0.5-17) years after the repair of an anomalous origin of the left coronary artery from the pulmonary artery; of them, 10 (50%) patients showed left ventricular wall scar tissue on current cardiac MRI...
November 1, 2017: Cardiology in the Young
James O'Neill, Andrew J Hogarth, Ian Pearson, Hannah Law, Robert Bowes, Ananth Kidambi, Stephen Wheatcroft, U Mohanaraj Sivananthan, Muzahir H Tayebjee
BACKGROUND: The assessment of myocardial viability is crucial before percutaneous coronary intervention (PCI) is carried out to ensure that the patient will gain benefit. Trans-coronary pacing (TCP) has previously been used to pace myocardium but may also provide information on myocardial viability. METHODS: Patients with a single, significant coronary stenosis requiring PCI were recruited. They underwent a cardiac MRI to assess myocardial viability. Prior to PCI, a coronary guidewire was used to measure pacing threshold, impedance, and R-wave amplitude in different myocardial segments to determine any association between the electrical parameters and myocardial viability...
October 16, 2017: Catheterization and Cardiovascular Interventions
Kazumasa Sonoda, Yasuo Okumura, Ichiro Watanabe, Koichi Nagashima, Hiroaki Mano, Rikitake Kogawa, Naoko Yamaguchi, Keiko Takahashi, Kazuki Iso, Kimie Ohkubo, Toshiko Nakai, Satoshi Kunimoto, Atsushi Hirayama
BACKGROUND: The relationship between cardiac contrast-enhanced magnetic resonance imaging (CE-MRI)-derived scar characteristics and substrate for ventricular tachycardia (VT) in patients with structural heart disease (SHD) has not been fully investigated. METHODS: This study included 51 patients (mean age, 63.3±15.1 years) who underwent CE-MRI with SHD and VT induction testing before ablation. Late gadolinium-enhanced (LGE) regions on MRI slices were quantified by thresholding techniques...
October 2017: Journal of Arrhythmia
Taku Omori, Tairo Kurita, Kaoru Dohi, Akihiro Takasaki, Tomoyuki Nakata, Shiro Nakamori, Naoki Fujimoto, Kakuya Kitagawa, Kozo Hoshino, Takashi Tanigawa, Hajime Sakuma, Masaaki Ito
Aims: Unrecognized myocardial scar by late gadolinium enhancement (LGE) magnetic resonance imaging (MRI) is strongly associated with cardiac event in patients with stable coronary artery disease. The purpose of this study was to evaluate the prognostic impact of unrecognized non-infarct-related LGE (non-IR-LGE) in patients with acute myocardial infarction (AMI). Methods and results: We studied 269 patients with a first clinical episode of AMI underwent cardiac MRI within 6 weeks after onset (209 men; age, 66 ± 12 years)...
July 27, 2017: European Heart Journal Cardiovascular Imaging
Pedro Morais, Sandro Queirós, Brecht Heyde, Jan Engvall, Jan D 'hooge, João L Vilaça
Cardiovascular diseases are among the leading causes of death and frequently result in local myocardial dysfunction. Among the numerous imaging modalities available to detect these dysfunctional regions, cardiac deformation imaging through tagged magnetic resonance imaging (t-MRI) has been an attractive approach. Nevertheless, fully automatic analysis of these data sets is still challenging. In this work, we present a fully automatic framework to estimate left ventricular myocardial deformation from t-MRI. This strategy performs automatic myocardial segmentation based on B-spline explicit active surfaces, which are initialized using an annular model...
August 7, 2017: Physics in Medicine and Biology
Paloma Gastelurrutia, Carolina Gálvez-Montón, Maria Luisa Cámara, Juan Bustamante-Munguira, Pablo García-Pavia, Pablo Avanzas, J Alberto San Román, Domingo Pascual-Figal, Eduardo de Teresa, Maria G Crespo-Leiro, Nicolás Manito, Julio Núñez, Francisco Fernández-Avilés, Ángel Caballero, Albert Teis, Josep Lupón, Ramón Brugada, Carlos Martín, Jacobo Silva, Ana Revilla-Orodea, Sergio J Cánovas, Jose M Melero, Jose J Cuenca-Castillo, Angel Gonzalez-Pinto, Antoni Bayes-Genis
INTRODUCTION: Cardiac adipose tissue is a source of progenitor cells with regenerative capacity. Studies in rodents demonstrated that the intramyocardial delivery of cells derived from this tissue improves cardiac function after myocardial infarction (MI). We developed a new reparative approach for damaged myocardium that integrates the regenerative properties of cardiac adipose tissue with tissue engineering. In the adipose graft transposition procedure (AGTP), we dissect a vascularised flap of autologous pericardial adipose tissue and position it over the myocardial scarred area...
August 4, 2017: BMJ Open
Auras R Atreya, Mitkumar Patel, Senthil K Sivalingam, Mathias L Stoenescu
A 67-year-old man with coronary artery disease (CAD) and left anterior descending artery (LAD) stent presented with symptomatic monomorphic ventricular tachycardia (VT) at a rate of 190 bpm requiring cardioversion. ECG showed left bundle branch block pattern and inferior axis, suggestive of a right ventricular outflow tract (RVOT) focus rather than left ventricular scar due to LAD territory myocardial infarction (MI). Echocardiography showed normal wall motion. Angiography revealed a patent mid-LAD stent. Cardiac MRI with delayed postcontrast sequence revealed several regions of hyperenhancement abnormality within the basal portion of the interventricular septum...
June 30, 2017: BMJ Case Reports
Anne L Bakker, Jan C Grutters, Ruth G Keijsers, Martijn C Post
PURPOSE OF REVIEW: To address the current recommendations for screening, diagnosis, and treatment of cardiac sarcoidosis and the difficulties to put these recommendations into clinical practice. RECENT FINDINGS: The incidence of cardiac sarcoidosis appears to be higher than earlier reported, probably because of improved imaging techniques. Late gadolinium enhancement with cardiac MRI (LGE-CMR) and fluorodeoxyglucose positron emission tomography obtained a central role in the diagnostic algorithm and monitoring of disease activity...
September 2017: Current Opinion in Pulmonary Medicine
Patrick Krumm, Tanja Zitzelsberger, Melanie Weinmann, Stefanie Mangold, Dominik Rath, Konstantin Nikolaou, Meinrad Gawaz, Ulrich Kramer, Bernhard Daniel Klumpp
PURPOSE: To compare left ventricular global function index (LVGFI) and quantitative late gadolinium enhancement (LGE) in patients with unrecognized myocardial infarction (UMI), recognized myocardial infarction (RMI) and without myocardial infarction (MI). MATERIAL AND METHODS: Under waiver of the Institutional Review Board 235 patients (age 63.5±10.5years, 57 female) were retrospectively evaluated. All patients had undergone cardiac MRI at 1.5T for symptoms of CAD...
July 2017: European Journal of Radiology
Ningchao Tao, Yuanhao Qiu, Haipeng Tang, Zhiyong Qian, Hongping Wu, Rui Zhu, Yao Wang, Xiaofeng Hou, Weihua Zhou, Jiangang Zou
BACKGROUND: The U-shaped left ventricular (LV) contraction pattern, identified by MRI or echocardiography, is associated with improved CRT response. Gated SPECT MPI can measure both myocardial viability and mechanical dyssynchrony in a single scan. The aim of this study is to examine the relationship of the LV contraction pattern and the response of CRT in patients with left bundle branch block (LBBB). METHODS: Fifty-eight patients who met CRT guidelines and who had pre-CRT MPI were enrolled...
June 12, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Jana Koth, Mahon L Maguire, Darryl McClymont, Leonie Diffley, Victoria L Thornton, John Beech, Roger K Patient, Paul R Riley, Jürgen E Schneider
The adult zebrafish is a well-established model for studying heart regeneration, but due to its tissue opaqueness, repair has been primarily assessed using destructive histology, precluding repeated investigations of the same animal. We present a high-resolution, non-invasive in vivo magnetic resonance imaging (MRI) method incorporating a miniature respiratory and anaesthetic perfusion set-up for live adult zebrafish, allowing for visualization of scar formation and heart regeneration in the same animal over time at an isotropic 31 µm voxel resolution...
June 7, 2017: Scientific Reports
Min Jeong Kim, Yeonyee E Yoon, Jin Joo Park, Yeo Koon Kim, Eun Ju Chun, Sang Il Choi, Goo-Young Cho
Coronary magnetic resonance angiography (CMRA) allows a noninvasive assessment of the coronary anatomy without exposing the patients to radiation. It is also superior to coronary computed tomography angiography (CCTA) for the evaluation of luminal narrowing in heavily calcified coronary segments. We report a case with triple-vessel disease, but it could not be accurately assessed by CCTA because of calcification and lack of a significant perfusion defect or myocardial scarring on cardiac magnetic resonance imaging (MRI)...
May 2017: Korean Circulation Journal
Kazuo Sakamoto, Masatsugu Nozoe, Yoshitomo Tsutsui, Nobuhiro Suematsu, Toru Kubota, Masanori Okabe, Yusuke Yamamoto
Cardiac magnetic resonance imaging (MRI) is a useful tool for detecting the arrhythmogenic substrate in cardiac sarcoidosis. We herein present a case of bipolar radiofrequency catheter ablation for ventricular tachycardia (VT) complicated with cardiac sarcoidosis, guided by pre-procedural cardiac MRI. Neither echocardiography nor endocardial voltage mapping suggested a septal VT substrate. However, MRI alone detected intramural lesions in the septum. Although application of endocardial energy failed to treat the VT, bipolar ablation targeting the potential substrate identified by MRI successfully eliminated the VT...
2017: International Medical Case Reports Journal
Friederike Behmenburg, Nina Hölscher, Ulrich Flögel, Markus W Hollmann, André Heinen, Ragnar Huhn
BACKGROUND: Opening of mitochondrial calcium-activated potassium channels (BKCa) reduces infarct size after myocardial ischemia/reperfusion injury (I/R). It is unknown if targeting BKCa-channels improves cardiac performance in the long-term after I/R. METHODS: Experiments were conducted in compliance with institutional and national guidelines in C57BL/6 mice (n=7-8/group). Animals were randomized into two groups. Preconditioning was induced by intraperitoneal application of NS1619 (NS, 1μg/g bw) 10min before ischemia, control animals (Con) received the vehicle...
August 15, 2017: International Journal of Cardiology
Elisabeth H M Paiman, Hildo J Lamb
At present, most of the cardiac magnetic resonance imaging (MRI) examinations rely on contrast-enhanced protocols, but noncontrast alternatives are emerging. Late gadolinium enhancement (LGE) imaging for the detection of myocardial scar can be considered the main cause for the embedding of cardiac MRI into the clinical routine. The novel noncontrast technique of native T1 mapping shows promise for tissue characterization in ischemic and nonischemic cardiomyopathy and may provide additional information over conventional LGE imaging...
May 8, 2017: Journal of Magnetic Resonance Imaging: JMRI
Hans Thijs Van den Broek, Leon De Jong, Pieter A Doevendans, Steven A J Chamuleau, Frebus J Van Slochteren, René Van Es
Cardiac regenerative therapies aim to protect and repair the injured heart in patients with ischemic heart disease. By injecting stem cells or other biologicals that enhance angio- or vasculogenesis into the infarct border zone (IBZ), tissue perfusion is improved, and the myocardium can be protected from further damage. For maximum therapeutic effect, it is hypothesized that the regenerative substance is best delivered to the IBZ. This requires accurate injections and has led to the development of new injection techniques...
April 12, 2017: Journal of Visualized Experiments: JoVE
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