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Cardiac Mri scar

Marco Matteucci, Valentina Casieri, Khatia Gabisonia, Giovanni Donato Aquaro, Silvia Agostini, Giuseppe Pollio, Daniela Diamanti, Marco Rossi, Massimiliano Travagli, Valentina Porcari, Fabio A Recchia, Vincenzo Lionetti
AIMS: Combined magnetic resonance imaging (MRI) of molecular and morpho-functional changes might prove highly valuable for the elucidation of pathological processes involved in the development of cardiac diseases. Our aim was to test a novel MRI reporter gene for in vivo assessment of the canonical Wnt/β-catenin/TCF pathway activation, an important regulator of post-ischemic cardiac remodeling. METHODS AND RESULTS: We designed and developed a chimeric construct encoding for both of iron-binding human ferritin heavy chain (hFTH) controlled by the β-catenin-responsive TCF/Lef promoter and constitutively expressed green fluorescent protein (GFP)...
September 26, 2016: Cardiovascular Research
S Piel, M Kreuter, F Herth, H-U Kauczor, C-P Heußel
CLINICAL/METHODICAL ISSUE: Granulomas as signs of specific inflammation of the lungs are found in various diseases with pulmonary manifestations and represent an important imaging finding. STANDARD RADIOLOGICAL METHODS: The standard imaging modality for the work-up of granulomatous diseases of the lungs is most often thin-slice computed tomography (CT). There are a few instances, e. g. tuberculosis, sarcoidosis and silicosis, where a chest radiograph still plays an important role...
October 2016: Der Radiologe
Carolina Gálvez-Montón, Ramon Bragós, Carolina Soler-Boti Ja, Idoia Díaz-Güemes, Cristina Prat-Vidal, Verónica Crisóstomo, Francisco M Sánchez-Margallo, Aida Llucià-Valldeperas, Paco Bogónez-Franco, Isaac Perea-Gil, Santiago Roura, Antoni Bayes-Genis
: : Cardiac tissue engineering, which combines cells and biomaterials, is promising for limiting the sequelae of myocardial infarction (MI). We assessed myocardial function and scar evolution after implanting an engineered bioactive impedance graft (EBIG) in a swine MI model. The EBIG comprises a scaffold of decellularized human pericardium, green fluorescent protein-labeled porcine adipose tissue-derived progenitor cells (pATPCs), and a customized-design electrical impedance spectroscopy (EIS) monitoring system...
September 2, 2016: Stem Cells Translational Medicine
Marwa A Sabe, Sharif A Sabe, Kenya Kusunose, Scott D Flamm, Brian P Griffin, Deborah H Kwon
BACKGROUND: Decreased right ventricular (RV) ejection fraction (RVEF) portends poor prognosis in patients with ischemic cardiomyopathy, and previous studies have suggested an association between mitral regurgitation (MR) and RVEF. We sought to evaluate this association and whether mitral valve repair or replacement affects the relationship between RV function and mortality. METHODS: We included 588 patients (mean age, 63±11 years; 75% male) with ischemic cardiomyopathy who underwent cardiac magnetic resonance imaging between 2002 and 2008...
August 30, 2016: Circulation
Wook-Jin Chung, Ahryon Cho, Kyunghee Byun, Jeongsik Moon, Xiaohu Ge, Hye-Sun Seo, Ejung Moon, Rajesh Dash, Phillip C Yang
BACKGROUND: Apelin-13 (A13) regulates cardiac homeostasis. However, the effects and mechanism of A13 infusion after an acute myocardial injury (AMI) have not been elucidated. This study assesses the restorative effects and mechanism of A13 on the peri-infarct region in murine AMI model. METHODS: 51 FVB/N mice (12weeks, 30g) underwent AMI. A week following injury, continuous micro-pump infusion of A13 (0.5μg/g/day) and saline was initiated for 4-week duration. Dual contrast MRI was conducted on weeks 1, 2, 3, and 5, consisting of delayed-enhanced and manganese-enhanced MRI...
November 1, 2016: International Journal of Cardiology
Lewis E Holmes, Tuan L Nguyen, Leia Hee, James Otton, Daniel A Moses, John K French, Liza Thomas, David A B Richards, Craig P Juergens
BACKGROUND: Myocardial infarct size (IS) following ST-segment elevation myocardial infarction (STEMI) is an important prognostic factor. We assessed the Selvester 32-point QRS score from the 12-lead ECG for measurement of IS in STEMI patients receiving reperfusion therapy compared to cardiac magnetic resonance imaging (CMRI). Furthermore we sought to explore the impact of microvascular obstruction (MVO) on the scoring system, and determine factors contributing to discrepancies between CMRI IS and Selvester score...
October 1, 2016: International Journal of Cardiology
Gabriella Captur, Charlotte Manisty, James C Moon
Cardiovascular magnetic resonance (CMR) is a key imaging technique for cardiac phenotyping with a major clinical role. It can assess advanced aspects of cardiac structure and function, scar burden and other myocardial tissue characteristics but there is new information that can now be derived. This can fill many of the gaps in our knowledge with the potential to change thinking, disease classifications and definitions as well as patient care. Established techniques such as the late gadolinium enhancement technique are now embedded in clinical care...
September 15, 2016: Heart: Official Journal of the British Cardiac Society
Sachiko Yamazaki, Kiyoshi Doi, Satoshi Numata, Keiichi Itatani, Hidetake Kawajiri, Kazuki Morimoto, Kaichiro Manabe, Koki Ikemoto, Hitoshi Yaku
OBJECTIVES: We aimed to investigate the outcomes of surgical ventricular reconstruction (SVR) for ischaemic cardiomyopathy and to identify ideal candidates for this procedure using cardiac magnetic resonance imaging (MRI) studies. METHODS: We retrospectively examined 50 patients who underwent SVR and were preoperatively evaluated using cardiac MRI from 2004 to 2014. Cine MRI and gadolinium-enhanced MRI were performed to evaluate left ventricular (LV) volume and scarring...
June 28, 2016: European Journal of Cardio-thoracic Surgery
Antoni Bayes-Genis, Paloma Gastelurrutia, Maria-Luisa Cámara, Albert Teis, Josep Lupón, Cinta Llibre, Elisabet Zamora, Xavier Alomar, Xavier Ruyra, Santiago Roura, Ana Revilla, José Alberto San Román, Carolina Gálvez-Montón
BACKGROUND: The present study evaluates the safety and efficacy of the Adipose Graft Transposition Procedure (AGTP) as a biological regenerative innovation for patients with a chronic myocardial scar. METHODS: This prospective, randomized single-center controlled study included 10 patients with established chronic transmural myocardial scars. Candidates for myocardial revascularization were randomly allocated into two treatment groups. In the control arm (n=5), the revascularizable area was treated with CABG and the non-revascularizable area was left untouched...
May 2016: EBioMedicine
Anna Turco, Johan Nuyts, Olivier Gheysens, Jürgen Duchenne, Jens-Uwe Voigt, Piet Claus, Kathleen Vunckx
BACKGROUND: The limited spatial resolution of the clinical PET scanners results in image blurring and does not allow for accurate quantification of very thin or small structures (known as partial volume effect). In cardiac imaging, clinically relevant questions, e.g. to accurately define the extent or the residual metabolic activity of scarred myocardial tissue, could benefit from partial volume correction (PVC) techniques. The use of high-resolution anatomical information for improved reconstruction of the PET datasets has been successfully applied in other anatomical regions...
December 2016: EJNMMI Physics
Thomas M Gorter, Chris P H Lexis, Yoran M Hummel, Erik Lipsic, Robin Nijveldt, Tineke P Willems, Iwan C C van der Horst, Pim van der Harst, Joost P van Melle, Dirk J van Veldhuisen
Right ventricular (RV) dysfunction is a powerful risk marker after acute myocardial infarction (MI). Primary percutaneous coronary intervention (PCI) has markedly reduced myocardial damage of the left ventricle, but reliable data on RV damage using cardiac magnetic resonance imaging (MRI) are scarce. In a recent trial of patients with acute MI treated with primary PCI, in which the primary end point was left ventricular (LV) ejection fraction after 4 months measured with MRI, we conducted a prospectively defined substudy in which we examined RV function...
August 1, 2016: American Journal of Cardiology
Raquel Themudo, Lars Johansson, Charlotte Ebeling-Barbier, Lars Lind, Håkan Ahlström, Tomas Bjerner
OBJECTIVES: In an elderly population, the prevalence of unrecognized myocardial infarction (UMI) scars found via late gadolinium enhancement (LGE) cardiac magnetic resonance (CMR) imaging was more frequent than expected. This study investigated whether UMI scars detected with LGE-CMR at age 70 would be detectable at age 75 and whether the scar size changed over time. METHODS: From 248 participants that underwent LGE-CMR at age 70, 185 subjects underwent a follow-up scan at age 75...
June 2, 2016: European Radiology
P Bhagirath, A W M van der Graaf, J de Hooge, N M S de Groot, M J W Götte
BACKGROUND: Integration of whole-heart activation simulations and inverse potential mapping (IPM) could benefit the guidance and planning of electrophysiological procedures. Routine clinical application requires a fast and adaptable workflow. These requirements limit clinical translation of existing simulation models. This study proposes a comprehensive finite element model (FEM) based whole-heart computational workflow suitable for IPM and simulations. METHODS: Three volunteers and eight patients with premature ventricular contractions underwent body surface potential (BSP) acquisition followed by a cardiac MRI (CMR) scan...
2016: Journal of Translational Medicine
Ebru Golcuk, Kivanc Yalin, Tolga Aksu, Selma Kenar Tiryakioglu, Ahmet Kaya Bilge, Kamil Adalet
INTRODUCTION: The role of contrast-enhanced (ce) cardiac magnetic resonance in risk stratification of patients with depressed left ventricle (LV) function is widely studied. In this study, we investigated the myocardial infarct size and characteristics by ce-magnetic resonance imaging (MRI) and its relationship with spontaneous ventricular arrhythmia occurrence during follow-up of in patients with mild LV systolic dysfunction and nonsustained ventricular tachycardia (VT). MATERIALS AND METHODS: This study enrolled 32 patients with postmyocardial infarction with an LV ejection fraction between 40% and 50% and nonsustained VT...
May 2016: American Journal of the Medical Sciences
Wen-Yih Isaac Tseng, Mao-Yuan Marine Su, Yao-Hui Elton Tseng
UNLABELLED: Cardiovascular magnetic resonance (CMR) is a set of magnetic resonance imaging (MRI) techniques designed to assess cardiovascular morphology, ventricular function, myocardial perfusion, tissue characterization, flow quantification and coronary artery disease. Since MRI is a non-invasive tool and free of radiation, it is suitable for longitudinal monitoring of treatment effect and follow-up of disease progress. Compared to MRI of other body parts, CMR faces specific challenges from cardiac and respiratory motion...
March 2016: Acta Cardiol Sin
David Soto-Iglesias, Constantine Butakoff, David Andreu, Juan Fernández-Armenta, Antonio Berruezo, Oscar Camara
Integration of electrical and structural information for scar characterization in the left ventricle (LV) is a crucial step to better guide radio-frequency ablation therapies, which are usually performed in complex ventricular tachycardia (VT) cases. This integration requires finding a common representation where to map the electrical information from the electro-anatomical map (EAM) surfaces and tissue viability information from delay-enhancement magnetic resonance images (DE-MRI). However, the development of a consistent integration method is still an open problem due to the lack of a proper evaluation framework to assess its accuracy...
August 2016: Medical Image Analysis
Florian Blaschke, Florian Krackhardt, Bherous Kherad, Burkert Pieske, Wilhelm Haverkamp, Matthias Rief
CONTEXT: Congenital coronary anomalies, including anomalous origin, distribution, intercoronary communications, and coronary fistulae occur at a rate of approximately 1% in the general population and are the most incidental findings. CASE REPORT: A 49-year-old male patient presented to the emergency department with exercise-induced dyspnea and atypical angina pectoris. Coronary angiography (CAG) and contrast-enhanced 320-slice multidetector cardiac computed tomography with subsequent three-dimensional reconstructions revealed a single coronary artery (SCA) arising from the right sinus of Valsalva with a proximal branch giving rise to the left anterior descending coronary artery...
February 2016: North American Journal of Medical Sciences
Larisa G Tereshchenko, Elyar Ghafoori, Muammar M Kabir, Markus Kowalsky
AIM: The goal of this study was to compare associations between clinical and ECG predictors of cardiac resynchronization therapy (CRT) response with electrical dyssynchrony. METHODS: Body-surface potentials were recorded using a 120-lead system in 4 patients (age 62 ± 12 y, left ventricular ejection fraction (LVEF) 29 ± 5 %; QRS duration 154 ± 19 ms) with post-myocardial infarction scar and left bundle branch block before CRT implantation. A patient-specific heart-torso model derived from MRI with 291 heart-surface nodes was developed...
September 2015: Computing in Cardiology
Hideaki Kanazawa, Eleni Tseliou, James F Dawkins, Geoffrey De Couto, Romain Gallet, Konstantinos Malliaras, Kristine Yee, Michelle Kreke, Ileana Valle, Rachel R Smith, Ryan C Middleton, Chak-Sum Ho, Rohan Dharmakumar, Debiao Li, Raj R Makkar, Keiichi Fukuda, Linda Marbán, Eduardo Marbán
BACKGROUND: Infusion of allogeneic cardiosphere-derived cells (allo-CDCs) postreperfusion elicits cardioprotective cellular postconditioning in pigs with acute myocardial infarction. However, the long-term effects of allo-CDCs have not been assessed. We performed a placebo-controlled pivotal study for long-term evaluation, as well as shorter-term mechanistic studies. METHODS AND RESULTS: Minipigs underwent 1.5-hour mid-left anterior descending balloon occlusion followed by reperfusion and were randomized to receive intracoronary allo-CDCs or vehicle 30 minutes postreperfusion...
February 2016: Journal of the American Heart Association
Julie A Brothers, Timothy S Kim, Mark A Fogel, Kevin K Whitehead, Tonia M Morrison, Stephen M Paridon, Matthew A Harris
OBJECTIVES: Using cardiac magnetic resonance imaging (MRI) with virtual angioscopy, we sought to evaluate coronary anatomy, myocardial injury, and left ventricular function in children with interarterial anomalous aortic origin of coronary artery before and after surgery. METHODS: We prospectively enrolled children 5 to 19 years old with interarterial anomalous coronary artery. Cardiac MRI was performed with respiratory-navigated steady-state free-precession 3-dimensional data set acquisition...
July 2016: Journal of Thoracic and Cardiovascular Surgery
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