Lan Zhang, Zhenyu Yin, Xilei Liu, Ge Jin, Yan Wang, Linlin He, Meimei Li, Xiaoqi Pang, Bo Yan, Zexi Jia, Jiahui Ma, Jingge Wei, Fangyuan Cheng, Dai Li, Lu Wang, Zhaoli Han, Qiang Liu, Fanglian Chen, Hailong Cao, Ping Lei
Gut microbial homeostasis is crucial for the health of cognition in elderly. Previous study revealed that polysorbate 80 (P80) as a widely used emulsifier in food industries and pharmaceutical formulations could directly alter the human gut microbiota compositions. However, whether long-term exposure to P80 could accelerate age-related cognitive decline via gut-brain axis is still unknown. Accordingly, in this study, we used the senescence accelerated mouse prone 8 (SAMP8) mouse model to investigate the effects of the emulsifier P80 intake (1 % P80 in drinking water for 12 weeks) on gut microbiota and cognitive function...
March 31, 2024: Brain, Behavior, and Immunity