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https://www.readbyqxmd.com/read/27828920/re-mullers-muscle-conjunctival-resection-for-treatment-of-contact-lens-associated-ptosis
#1
Adam J Cohen
No abstract text is available yet for this article.
November 2016: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27825774/identification-and-evaluation-of-reference-genes-for-expression-studies-by-rt-qpcr-during-embryonic-development-of-the-emerging-model-organism-macrobrachium-olfersii
#2
Michael L Jaramillo, Dib Ammar, Ruth L Quispe, Frank Guzman, Rogerio Margis, Evelise M Nazari, Yara M R Müller
RT-qPCR is a sensitive and highly efficient technique that is widely used in gene expression analysis and to provide insight into the molecular mechanisms underlying embryonic development. The freshwater prawn, Macrobrachium olfersii is an emerging model organism, but, the stable reference genes of this species need to be identified and validated for RT-qPCR analysis. Thus, the aim of this study was to evaluate the expression stability of six genes (β-act, GAPDH, EF-1α, RpL8, RpS6, AK) in embryos and in adult tissues (cerebral ganglia, muscle and hepatopancreas) of M...
November 5, 2016: Gene
https://www.readbyqxmd.com/read/27824507/effects-of-muller-s-muscle-conjunctival-resection-for-ptosis-on-ocular-surface-scores-and-dry-eye-symptoms
#3
Bruna L Rymer, Diane R Marinho, Cristina Cagliari, Samara B Marafon, Fernando Procianoy
This article evaluates the effects of Muller's muscle-conjunctival resection (MMCR) on ocular surface scores and dry eye symptoms. Forty-six patients were enrolled in the study. Eighteen underwent bilateral upper eyelid skin excision with MMCR and 28 underwent bilateral upper eyelid skin-only excision (control group). The Salisbury Eye Evaluation Questionnaire and an ocular surface evaluation protocol consisting of Schirmer's test, tear break-up time (TBUT), fluorescein and rose bengal corneal staining were performed during the pre-operative consultation and on postoperative days 7, 30, and 90...
November 8, 2016: Orbit
https://www.readbyqxmd.com/read/27798357/muscle-oxygenation-during-dynamic-plantar-flexion-exercise-combining-bold-mri-with-traditional-physiological-measurements
#4
Matthew D Muller, Zhijun Li, Christopher T Sica, J Carter Luck, Zhaohui Gao, Cheryl A Blaha, Aimee E Cauffman, Amanda J Ross, Nathan J R Winkler, Michael D Herr, Kristen Brandt, Jianli Wang, David C Gallagher, Prasanna Karunanayaka, Jeffrey Vesek, Urs A Leuenberger, Qing X Yang, Lawrence I Sinoway
Blood-oxygen-level-dependent magnetic resonance imaging (BOLD MRI) has the potential to quantify skeletal muscle oxygenation with high temporal and high spatial resolution. The purpose of this study was to characterize skeletal muscle BOLD responses during steady-state plantar flexion exercise (i.e., during the brief rest periods between muscle contraction). We used three different imaging modalities (ultrasound of the popliteal artery, BOLD MRI, and near-infrared spectroscopy [NIRS]) and two different exercise intensities (2 and 6 kg)...
October 2016: Physiological Reports
https://www.readbyqxmd.com/read/27796491/nerve-supply-of-the-subscapularis-during-anterior-shoulder-surgery-definition-of-a-potential-risk-area
#5
Tim Leschinger, Michael Hackl, Felix Zeifang, Martin Scaal, Lars Peter Müller, Kilian Wegmann
PURPOSE: The purpose of the study was to evaluate the position of the subscapular nerves relative to surgical landmarks during exposure and to analyze the pattern of innervation of the subscapularis to avoid injury during anterior shoulder surgery. METHODS: 20 embalmed human cadaveric shoulder specimens were used in the study. The muscular insertions of the subscapular nerves were marked and their closest branches to the musculotendinous junction and the coracoid process were measured in horizontal and vertical distances...
October 28, 2016: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/27783446/dynamic-characteristics-of-t2-weighted-signal-in-calf-muscles-of-peripheral-artery-disease-during-low-intensity-exercise
#6
Zhijun Li, Matthew D Muller, Jianli Wang, Christopher T Sica, Prasanna Karunanayaka, Lawrence I Sinoway, Qing X Yang
PURPOSE: To evaluate the dynamic characteristics of T2* -weighted signal change in exercising skeletal muscle of healthy subjects and peripheral artery disease (PAD) patients under a low-intensity exercise paradigm. MATERIALS AND METHODS: Nine PAD patients and nine age- and sex-matched healthy volunteers underwent a low-intensity exercise paradigm while magnetic resonance imaging (MRI) (3.0T) was obtained. T2*-weighted signal time-courses in lateral gastrocnemius, medial gastrocnemius, soleus, and tibialis anterior were acquired and analyzed...
October 26, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27782104/homozygous-syne1-mutation-causes-congenital-onset-of-muscular-weakness-with-distal-arthrogryposis-a-genotype-phenotype-correlation
#7
Matthias Baumann, Elisabeth Steichen-Gersdorf, Birgit Krabichler, Britt-Sabina Petersen, Ulrike Weber, Wolfgang M Schmidt, Johannes Zschocke, Thomas Müller, Reginald E Bittner, Andreas R Janecke
The exceptionally large SYNE1 (spectrin repeat-containing nuclear envelope protein 1) gene encodes different nesprin-1 isoforms, which are differentially expressed in striated muscle and in cerebellar and cerebral neurons. Nesprin-1 isoforms can function in cytoskeletal, nuclear, and vesicle anchoring. SYNE1 variants have been associated with a spectrum of neurological and neuromuscular disease. Homozygosity mapping combined with exome sequencing identified a disease-causing nonsense mutation in the ultimate exon of full-length SYNE1 transcript in an 8-year-old boy with distal arthrogryposis and muscular hypotonia...
October 26, 2016: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/27759067/impact-of-weight-loss-associated-changes-in-detailed-body-composition-as-assessed-by-whole-body-mri-on-plasma-insulin-levels-and-homeostatis-model-assessment-index
#8
M Pourhassan, C-C Glüer, P Pick, W Tigges, M J Müller
BACKGROUND/OBJECTIVES: We assessed the effect of weight loss-associated changes in detailed body composition on plasma insulin levels and homeostatic model assessment (HOMA) index to calculate the magnitude of reduction in different adipose tissue depots required to improve insulin sensitivity. SUBJECTS/METHODS: A total of 50 subjects aged 20-69 years were studied. The participants were compiled from low-calorie diet interventions and bariatric surgery and differed in their baseline body mass index (BMI; range 21...
October 19, 2016: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27757008/predictive-images-of-postoperative-levator-resection-outcome-using-image-processing-software
#9
Yuki Mawatari, Mikiko Fukushima
PURPOSE: This study aims to evaluate the efficacy of processed images to predict postoperative appearance following levator resection. METHODS: Analysis involved 109 eyes from 65 patients with blepharoptosis who underwent advancement of levator aponeurosis and Müller's muscle complex (levator resection). Predictive images were prepared from preoperative photographs using the image processing software (Adobe Photoshop(®)). Images of selected eyes were digitally enlarged in an appropriate manner and shown to patients prior to surgery...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27706396/wound-healing-potential-of-sebastiania-hispida-mart-pax-euphorbiaceae-ointment-compared-to-low-power-laser-in-rats
#10
E S Rizzi, D M Dourado, R Matias, J A I Muller, J F Guilhermino, A T G Guerrero, D L Moreira, B A K Silva, M Barbosa-Ferreira
Impaired wound healing represents a serious complication in some pathologies and the use of plant extracts has proved to improve tissue repair. The objectives of this study were to evaluate the healing potential of the ointment of Sebastiana hispida compared with Aluminum-Gallium Indium-Phosphide Laser (InGaAlP) in surgically induced wounds in rats and to perform the phytochemical analysis. The phytochemical analysis was performed in the classic way and also by HPLC. A controlled study was developed with 80 rats (200-250 g) in which a linear excision was performed in the dorsal region after shaving, measuring 2 cm × 1 cm (epidermis and dermis) exposing the muscle fascia...
October 3, 2016: Brazilian Journal of Biology, Revista Brasleira de Biologia
https://www.readbyqxmd.com/read/27688995/%C3%AE-melanocyte-stimulating-hormone-promotes-muscle-glucose-uptake-via-melanocortin-5-receptors
#11
Pablo J Enriori, Weiyi Chen, Maria C Garcia-Rudaz, Bernadette E Grayson, Anne E Evans, Sarah M Comstock, Ursel Gebhardt, Hermann L Müller, Thomas Reinehr, Belinda A Henry, Russell D Brown, Clinton R Bruce, Stephanie E Simonds, Sara A Litwak, Sean L McGee, Serge Luquet, Sarah Martinez, Martin Jastroch, Matthias H Tschöp, Matthew J Watt, Iain J Clarke, Christian L Roth, Kevin L Grove, Michael A Cowley
OBJECTIVE: Central melanocortin pathways are well-established regulators of energy balance. However, scant data exist about the role of systemic melanocortin peptides. We set out to determine if peripheral α-melanocyte stimulating hormone (α-MSH) plays a role in glucose homeostasis and tested the hypothesis that the pituitary is able to sense a physiological increase in circulating glucose and responds by secreting α-MSH. METHODS: We established glucose-stimulated α-MSH secretion using humans, non-human primates, and mouse models...
October 2016: Molecular Metabolism
https://www.readbyqxmd.com/read/27659466/52-genetic-loci-influencing-myocardial%C3%A2-mass
#12
Pim van der Harst, Jessica van Setten, Niek Verweij, Georg Vogler, Lude Franke, Matthew T Maurano, Xinchen Wang, Irene Mateo Leach, Mark Eijgelsheim, Nona Sotoodehnia, Caroline Hayward, Rossella Sorice, Osorio Meirelles, Leo-Pekka Lyytikäinen, Ozren Polašek, Toshiko Tanaka, Dan E Arking, Sheila Ulivi, Stella Trompet, Martina Müller-Nurasyid, Albert V Smith, Marcus Dörr, Kathleen F Kerr, Jared W Magnani, Fabiola Del Greco M, Weihua Zhang, Ilja M Nolte, Claudia T Silva, Sandosh Padmanabhan, Vinicius Tragante, Tõnu Esko, Gonçalo R Abecasis, Michiel E Adriaens, Karl Andersen, Phil Barnett, Joshua C Bis, Rolf Bodmer, Brendan M Buckley, Harry Campbell, Megan V Cannon, Aravinda Chakravarti, Lin Y Chen, Alessandro Delitala, Richard B Devereux, Pieter A Doevendans, Anna F Dominiczak, Luigi Ferrucci, Ian Ford, Christian Gieger, Tamara B Harris, Eric Haugen, Matthias Heinig, Dena G Hernandez, Hans L Hillege, Joel N Hirschhorn, Albert Hofman, Norbert Hubner, Shih-Jen Hwang, Annamaria Iorio, Mika Kähönen, Manolis Kellis, Ivana Kolcic, Ishminder K Kooner, Jaspal S Kooner, Jan A Kors, Edward G Lakatta, Kasper Lage, Lenore J Launer, Daniel Levy, Alicia Lundby, Peter W Macfarlane, Dalit May, Thomas Meitinger, Andres Metspalu, Stefania Nappo, Silvia Naitza, Shane Neph, Alex S Nord, Teresa Nutile, Peter M Okin, Jesper V Olsen, Ben A Oostra, Josef M Penninger, Len A Pennacchio, Tune H Pers, Siegfried Perz, Annette Peters, Yigal M Pinto, Arne Pfeufer, Maria Grazia Pilia, Peter P Pramstaller, Bram P Prins, Olli T Raitakari, Soumya Raychaudhuri, Ken M Rice, Elizabeth J Rossin, Jerome I Rotter, Sebastian Schafer, David Schlessinger, Carsten O Schmidt, Jobanpreet Sehmi, Herman H W Silljé, Gianfranco Sinagra, Moritz F Sinner, Kamil Slowikowski, Elsayed Z Soliman, Timothy D Spector, Wilko Spiering, John A Stamatoyannopoulos, Ronald P Stolk, Konstantin Strauch, Sian-Tsung Tan, Kirill V Tarasov, Bosco Trinh, Andre G Uitterlinden, Malou van den Boogaard, Cornelia M van Duijn, Wiek H van Gilst, Jorma S Viikari, Peter M Visscher, Veronique Vitart, Uwe Völker, Melanie Waldenberger, Christian X Weichenberger, Harm-Jan Westra, Cisca Wijmenga, Bruce H Wolffenbuttel, Jian Yang, Connie R Bezzina, Patricia B Munroe, Harold Snieder, Alan F Wright, Igor Rudan, Laurie A Boyer, Folkert W Asselbergs, Dirk J van Veldhuisen, Bruno H Stricker, Bruce M Psaty, Marina Ciullo, Serena Sanna, Terho Lehtimäki, James F Wilson, Stefania Bandinelli, Alvaro Alonso, Paolo Gasparini, J Wouter Jukema, Stefan Kääb, Vilmundur Gudnason, Stephan B Felix, Susan R Heckbert, Rudolf A de Boer, Christopher Newton-Cheh, Andrew A Hicks, John C Chambers, Yalda Jamshidi, Axel Visel, Vincent M Christoffels, Aaron Isaacs, Nilesh J Samani, Paul I W de Bakker
BACKGROUND: Myocardial mass is a key determinant of cardiac muscle function and hypertrophy. Myocardial depolarization leading to cardiac muscle contraction is reflected by the amplitude and duration of the QRS complex on the electrocardiogram (ECG). Abnormal QRS amplitude or duration reflect changes in myocardial mass and conduction, and are associated with increased risk of heart failure and death. OBJECTIVES: This meta-analysis sought to gain insights into the genetic determinants of myocardial mass...
September 27, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27650854/adipocyte-glucocorticoid-receptor-deficiency-attenuates-aging-and-hfd-induced-obesity-and-impairs-the-feeding-fasting-transition
#13
Kristina M Mueller, Kerstin Hartmann, Doris Kaltenecker, Sabine Vettorazzi, Mandy Bauer, Lea Mauser, Sabine Amann, Sigrid Jall, Katrin Fischer, Harald Esterbauer, Timo D Müller, Matthias H Tschöp, Christoph Magnes, Johannes Haybaeck, Thomas Scherer, Natalie Bordag, Jan P Tuckermann, Richard Moriggl
Glucocorticoids (GCs) are important regulators of systemic energy metabolism, while aberrant GC action is linked to metabolic dysfunctions. Yet, the extent to which normal and pathophysiologic energy metabolism depend on the glucocorticoid receptor (GR) in adipocytes remains unclear. Here, we demonstrate that adipocyte GR-deficiency in mice significantly impacts systemic metabolism in different energetic states. Plasma metabolomics and biochemical analyses revealed a marked global effect of GR-deficiency on systemic metabolite abundance and thus, substrate partitioning in fed and fasted states...
September 20, 2016: Diabetes
https://www.readbyqxmd.com/read/27649501/determination-of-thyroid-hormones-in-mouse-tissues-by-isotope-dilution-microflow-liquid-chromatography-mass-spectrometry-method
#14
Meri De Angelis, Florian Giesert, Brian Finan, Christoffer Clemmensen, Timo D Müller, Daniela Vogt-Weisenhorn, Matthias H Tschöp, Karl-Werner Schramm
Thyroid hormones (THs) play a critical role in the regulation of many biological processes such as growth, metabolism and development both in humans and wildlife. In general, TH levels are measured by immunoassay (IA) methods but the specificity of the antibodies used in these assays limits selectivity. In the last decade, several analytical methods using liquid chromatography-mass spectrometry (LC-MS) and tandem mass spectrometry (LC-MS/MS) have been developed to measure THs. These new techniques proved to be more accurate than the IA analysis and they were widely used for the determination of TH level in different human and animal tissues...
October 15, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27644327/altered-interleukin-10-signaling-in-skeletal-muscle-regulates-obesity-mediated-inflammation-and-insulin-resistance
#15
Sezin Dagdeviren, Dae Young Jung, Eunjung Lee, Randall H Friedline, Hye Lim Noh, Jong Hun Kim, Payal R Patel, Nicholas Tsitsilianos, Andrew V Tsitsilianos, Duy A Tran, George H Tsougranis, Caitlyn C Kearns, Cecilia P Uong, Jung Yeon Kwon, Werner Muller, Ki Won Lee, Jason K Kim
Skeletal muscle insulin resistance is a major characteristic of obesity and type 2 diabetes. Although obesity-mediated inflammation is causally associated with insulin resistance, the underlying mechanism is unclear. Here, we examined the effects of chronic obesity in mice with muscle-specific overexpression of interleukin-10 (M(IL10)). After 16 weeks of a high-fat diet (HFD), M(IL10) mice became markedly obese but showed improved insulin action compared to that of wild-type mice, which was largely due to increased glucose metabolism and reduced inflammation in skeletal muscle...
December 1, 2016: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/27612554/evaluation-of-accessory-lacrimal-gland-in-muller-s-muscle-conjunctival-resection-specimens-for-precursor-cell-markers-and-biological-markers-of-dry-eye-disease
#16
Marwan Ali, Dhara Shah, Zeeshan Pasha, Sarmad H Jassim, Assraa Jassim Jaboori, Pete Setabutr, Vinay K Aakalu
PURPOSE: The accessory lacrimal glands (ALGs) are an understudied component of the tear functional unit, even though they are important in the development of dry eye syndrome (DES). To advance our understanding of aging changes, regenerative potential, and histologic correlates to human characteristics, we investigated human ALG tissue from surgical samples to determine the presence or absence of progenitor cell markers and lacrimal epithelial markers and to correlate marker expression to relevant patient characteristics...
September 9, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27581576/estimation-of-skeletal-muscle-mass-and-visceral-adipose-tissue-volume-by-a-single-magnetic-resonance-imaging-slice-in-healthy-elderly-adults
#17
Lisa Schweitzer, Corinna Geisler, Maryam Pourhassan, Wiebke Braun, Claus-Christian Glüer, Anja Bosy-Westphal, Manfred J Müller
BACKGROUND: Assessing skeletal muscle (SM) and visceral adipose tissue (VAT) by a single MRI slice at lumbar vertebra (L) 3 can replace whole-body MRI in young and middle-aged adults. However, this technique has not been proven in older adults. OBJECTIVE: The aim of this analysis was to reinvestigate the best estimate for SM and VAT in an independent population of healthy elderly people. METHODS: SM and VAT were assessed by whole-body MRI in 84 subjects ≥60 y [45 men; mean ± SD age: 68...
October 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27579226/vermilion-reconstruction-with-genital-mucosa
#18
Urs D A Müller-Richter, Gerhard H Weyandt, Achim Woeckel, Alexander C Kübler
Functional and aesthetical reconstruction, especially of the upper lip after ablative tumor surgery, can be very challenging. The skin of the lip might be sufficiently reconstructed by transpositional flaps from the nasolabial or facial area. Large defects of the lip mucosa, including the vestibule, are even more challenging due to the fact that flaps from the inner lining of the oral cavity often lead to functional impairments. We present a case of multiple vermilion and skin resections of the upper lip. At the last step, we had to resect even the whole vermilion mucosa, including parts of the oral mucosa of the vestibule, leaving a bare orbicularis oris muscle...
May 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27558328/transendothelial-migration-unifying-principles-from-the-endothelial-perspective
#19
REVIEW
William A Muller
Transendothelial migration (TEM) of polymorphonuclear leukocytes (PMN) involves a carefully orchestrated dialog of adhesion and signaling events between leukocyte and endothelial cell. This article focuses on the contribution of endothelial cells to transmigration. The initiation of TEM itself generally requires interaction of PECAM on the leukocyte with PECAM at the endothelial cell border. This is responsible for the transient elevation of cytosolic-free calcium ions in endothelium that is required for TEM and for recruitment of membrane from the lateral border recycling compartment (LBRC)...
September 2016: Immunological Reviews
https://www.readbyqxmd.com/read/27554370/pharmacological-treatment-of-post-prostatectomy-incontinence-what-is-the-evidence
#20
Anja Løvvik, Stig Müller, Hitendra R H Patel
Urinary incontinence is a common and debilitating problem, and post-prostatectomy incontinence (PPI) is becoming an increasing problem, with a higher risk among elderly men. Current treatment options for PPI include pelvic floor muscle exercises and surgery. Conservative treatment has disputable effects, and surgical treatment is expensive, is not always effective, and may have complications. This article describes the prevalence and causes of PPI and the current treatment methods. We conducted a search of the PUBMED database and reviewed the current literature on novel medical treatments of PPI, with special focus on the aging man...
August 2016: Drugs & Aging
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