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Hurthle cell carcinoma

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https://www.readbyqxmd.com/read/28214214/diagnostic-utility-of-ck19-and-cd56-in-the-differentiation-of-thyroid-papillary-carcinoma-from-its-mimics
#1
Nehal S Abouhashem, Suzan M Talaat
BACKGROUND: Papillary Thyroid Carcinoma (PTC) is the most common type of malignant thyroid tumors. The main diagnostic clue of PTC is the presence of its characteristic nuclear features. Yet, the focal presence of these features in other thyroid lesions causes a diagnostic dilemma. AIM: To evaluate Cytokeratin 19 (CK19) and CD56 immunostains as useful diagnostic markers in distinguishing papillary thyroid carcinoma from other mimicking thyroid lesions. METHODS: Eighty cases of different thyroid lesions were submitted for immunohistochemical staining of CK19 and CD56...
January 22, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28028337/thyroid-fnac-containing-h%C3%A3-rthle-cells-and-h%C3%A3-rthle-like-cells-a-study-of-128-cases
#2
Aylin Yazgan, Serdar Balci, Nazmiye Dincer, Pamir Eren Ersoy, Dilek Tuzun, Reyhan Ersoy, Cigdem Irkkan, Bekir Cakir, Gulnur Guler
AIM: It is a diagnostic challenge to differentiate benign and malignant cytology in the presence of Hürthle cells. In our previous study, it was determined that in fine needle aspirations (FNA), the malignancy outcome of the Hürthle cells containing group tend to be papillary thyroid carcinoma (PTC) in a higher percentage. The most common misinterpretation is caused by PTC cells with large cytoplasm-like Hürthle cells. The aim of this study is to predict histologic outcome of the nodules, which have Hürthle cells in FNA according to cytological, clinical features, and BRAF(V600E) mutation status...
October 2016: Journal of Cytology
https://www.readbyqxmd.com/read/27943373/most-thyroid-cancers-detected-by-sonography-lack-intranodular-vascularity-on-color-doppler-imaging-review-of-the-literature-and-sonographic-pathologic-correlations-for-698-thyroid-neoplasms
#3
Grace C H Yang, Karen O Fried
OBJECTIVES: This study investigated the controversy of whether hypervascularity on color Doppler sonography correlates with thyroid malignancy by reviewing the literature and sonographic-pathologic correlation. METHODS: Over a 20-year period, 698 thyroid nodules had color Doppler and histopathologic data. Intranodular vascularity was graded 0 to 3+, and histopathologic findings were recorded. RESULTS: The data were collected from 698 patients (557 women and 141 men) with a mean age of 48 years (range, 16-87 years)...
December 1, 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/27929675/imaging-surveillance-in-patients-after-a-benign-fine-needle-aspiration-biopsy-of-the-thyroid-associated-cost-and-incidence-of-subsequent-cancer
#4
David J S Becker-Weidman, Neil Malhotra, David F Reilly, Naveen Selvam, Laurence Parker, Levon N Nazarian
OBJECTIVE: The objective of our study was to determine patterns and cost of imaging tumor surveillance in patients after a benign fine-needle aspiration (FNA) biopsy of the thyroid in a large teaching hospital as well as the rate of subsequent cancer detection. MATERIALS AND METHODS: This cohort study was approved by the appropriate institutional review board and complied with HIPAA. All patients who had a benign thyroid FNA biopsy between January 1, 1999, and December 31, 2003, were identified from an institutional pathology database...
February 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27885512/clinicopathological-features-of-thyroid-cancer-in-the-elderly-compared-to-younger-counterparts-single-center-experience
#5
F D Dellal, D Özdemir, A A Tam, H Baser, H Tatli Dogan, O Parlak, R Ersoy, B Cakir
PURPOSE: The incidence of thyroid cancer is increased in elderly patients. It tends to be larger and have more aggressive characteristics in these patients. Our aim was to compare features of thyroid carcinoma in geriatric and non-geriatric patients. METHODS: In total, 933 patients with thyroid cancer were retrospectively reviewed. Thyroid functions, ultrasonography features of malignant nodules, cytological and histopathological findings and the rates of recurrence and persistence were compared in patients ≥65 and <65 years old...
November 24, 2016: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/27856495/clinical-outcomes-of-a-cohort-of-patients-with-central-nervous-system-metastases-from-thyroid-cancer
#6
Joana Simões-Pereira, Daniel Macedo, Maria João Bugalho
INTRODUCTION: Metastases to central nervous system (M1-CNS) are rarely reported in thyroid cancer (TC) patients. We aimed to characterize patients with M1-CNS from TC followed in our department. METHODS: Review of the medical records of 27 patients with TC-related M1-CNS. RESULTS: Mean age at TC diagnosis was 56.9 ± 19.1 years. Papillary TC (55.6%) was the commonest histological type, followed by poorly differentiated (18.5%), medullary (11...
November 2016: Endocrine Connections
https://www.readbyqxmd.com/read/27853381/h%C3%A3-rthle-cell-carcinoma-current-perspectives
#7
REVIEW
Sara Ahmadi, Michael Stang, Xiaoyin Sara Jiang, Julie Ann Sosa
Hürthle cell carcinoma (HCC) can present either as a minimally invasive or as a widely invasive tumor. HCC generally has a more aggressive clinical behavior compared with the other differentiated thyroid cancers, and it is associated with a higher rate of distant metastases. Minimally invasive HCC demonstrates much less aggressive behavior; lesions <4 cm can be treated with thyroid lobectomy alone, and without radioactive iodine (RAI). HCC has been observed to be less iodine-avid compared with other differentiated thyroid cancers; however, recent data have demonstrated improved survival with RAI use in patients with HCC >2 cm and those with nodal and distant metastases...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27816963/defective-ciliogenesis-in-thyroid-h%C3%A3-rthle-cell-tumors-is-associated-with-increased-autophagy
#8
Junguee Lee, Shinae Yi, Yea Eun Kang, Joon Young Chang, Jung Tae Kim, Hae Joung Sul, Jong Ok Kim, Jin Man Kim, Joon Kim, Anna Maria Porcelli, Koon Soon Kim, Minho Shong
Primary cilia are found in the apical membrane of thyrocytes, where they may play a role in the maintenance of follicular homeostasis. In this study, we examined the distribution of primary cilia in the human thyroid cancer to address the involvement of abnormal ciliogenesis in different thyroid cancers. We examined 92 human thyroid tissues, including nodular hyperplasia, Hashimoto's thyroiditis, follicular tumor, Hürthle cell tumor, and papillary carcinoma to observe the distribution of primary cilia. The distribution and length of primary cilia facing the follicular lumen were uniform across variable-sized follicles in the normal thyroid gland...
October 31, 2016: Oncotarget
https://www.readbyqxmd.com/read/27728172/diffuse-toxic-goiter-and-coexisting-hurthle-cell-carcinoma-of-thyroid-presenting-as-lower-limb-weakness-from-mononeuritis-multiplex
#9
Kadhiravan
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27679545/functional-polymorphisms-in-antioxidant-genes-in-hurthle-cell-thyroid-neoplasm-an-association-of-gpx1-polymorphism-and-recurrent-hurthle-cell-thyroid-carcinoma
#10
Blaz Krhin, Katja Goricar, Barbara Gazic, Vita Dolzan, Nikola Besic
BACKGROUND: Hurthle cells of the thyroid gland are very rich in mitochondria and oxidative enzymes. As a high level oxidative metabolism may lead to higher level of oxidative stress and can be associated with an increased risk for cancer, we investigated whether common functional polymorphisms in antioxidant genes (SOD2, CAT, GPX, GSTP1, GSTM1 and GSTT1) are associated with the development or clinical course of Hurthle cell thyroid carcinoma (HCTC). METHODS: A retrospective study was performed in 139 patients treated by thyroid surgery for a Hurthle cell neoplasm...
September 1, 2016: Radiology and Oncology
https://www.readbyqxmd.com/read/27679542/recurrence-rate-in-regional-lymph-nodes-in-737-patients-with-follicular-or-h%C3%A3-rthle-cell-neoplasms
#11
Andrej Vogrin, Hana Besic, Nikola Besic, Maja Marolt Music
BACKGROUND: Preoperative ultrasound (US) evaluation of central and lateral neck compartments is recommended for all patients undergoing a thyroidectomy for malignant or suspicious for malignancy cytologic or molecular findings. Our aim was to find out how frequent was recurrence in regional lymph nodes in patients with follicular or Hürthle cell neoplasm and usefulness of preoperative neck US investigation in patients with neoplasm. PATIENTS AND METHODS: Altogether 737 patients were surgically treated because of follicular or Hürthle cell neoplasms from 1995 to 2014 at our cancer comprehensive center, among them 207 patients (163 females, 44 males; mean age 52 years) had thyroid carcinoma...
September 1, 2016: Radiology and Oncology
https://www.readbyqxmd.com/read/27658752/comparison-of-ultrasound-pathologic-and-prognostic-characteristics-of-the-follicular-variant-of-papillary-thyroid-cancer-according-to-fine-needle-aspiration-cytology
#12
Jieun Koh, Eun-Kyung Kim, Ji-Ye Kim, Jin Young Kwak, Jung Hyun Yoon, Hee Jung Moon
The aim of the study described here was to compare ultrasound features, pathologic characteristics and prognoses of the follicular variant of papillary thyroid carcinoma (FVPTC) according to cytology results. Eighty-seven FVPTCs were classified according to the first cytology results as the surgery group (n = 66, follicular neoplasm/Hürthle cell neoplasm, suspicious for malignancy and malignancy) and the indeterminate group (n = 21, non-diagnostic and benign), for whom the management was follow-up. The indeterminate group had a longer mean interval to surgery (p = 0...
December 2016: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/27605259/analytical-performance-of-a-gene-expression-classifier-for-medullary-thyroid-carcinoma
#13
Daniel G Pankratz, Zhanzhi Hu, Su Yeon Kim, Robert J Monroe, Mei G Wong, S Thomas Traweek, Richard T Kloos, P Sean Walsh, Giulia C Kennedy
BACKGROUND: To demonstrate the analytical validity of an RNA classifier for medullary thyroid carcinoma (MTC). METHODS: Fresh-frozen tissue specimens were obtained from commercial sources, and MTC diagnoses were confirmed by histopathology review. De-identified patient fine-needle aspiration biopsies (FNABs) and whole blood from normal donors were obtained. Total RNA was extracted, amplified, and hybridized to custom microarrays for gene expression analysis. Gene expression data was normalized and classified via a machine learning algorithm...
September 7, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27547222/expression-of-mirna-and-occurrence-of-distant-metastases-in-patients-with-h%C3%A3-rthle-cell-carcinoma
#14
Rok Petric, Barbara Gazic, Katja Goricar, Vita Dolzan, Radan Dzodic, Nikola Besic
Background. Hürthle cell thyroid carcinoma (HCTC) is a rare type of thyroid carcinoma. In the present study, we investigated whether the expression of miRNAs of interest is associated with the occurrence of metastases in patients with HCTC. Materials and Methods. In 39 patients with HCTC (22 with nonmetastatic and 17 with regional or distant metastatic disease), the expression levels of six miRNAs (miR-138, miR-183, miR-221, miR-222, miR-768-3p, and miR-885-5p) and U6 snRNA as endogenous control were determined in FFPE samples of primary tumor and normal thyroid tissue using TaqMan miRNA assays...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27501796/23-lung-metastases-treated-by-radiofrequency-ablation-over-10%C3%A2-years-in-a-single-patient-successful-oncological-outcome-of-a-metastatic-cancer-without-altered-respiratory-function
#15
Amandine Crombé, Xavier Buy, Yann Godbert, Nicolas Alberti, Michèle Kind, Françoise Bonichon, Jean Palussière
An 82-year-old man, who was diagnosed in 2002 with an oncocytic (Hürthle cell) thyroid carcinoma, was initially treated by local surgery and was refractory to radioiodine treatment. The patient had successive secondary recurrences from 2006 onwards. Metastases were suspected due to an elevation of thyroglobulin in serum. Hypermetabolic nodules were targeted using FDG PET as well as CT-guided radiofrequency ablations. Thyroglobulin levels decreased following each procedure. 10 years later, tolerance and efficacy are excellent; 23 lung metastases have been treated during 11 sessions without current relapse...
December 2016: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/27480016/clinicopathologic-features-of-fatal-non-anaplastic-follicular-cell-derived-thyroid-carcinomas
#16
Bin Xu, Tihana Ibrahimpasic, Laura Wang, Mona M Sabra, Jocelyn C Migliacci, R Michael Tuttle, Ian Ganly, Ronald Ghossein
BACKGROUND: The vast majority of thyroid cancers, in particular the non-anaplastic follicular cell-derived thyroid carcinomas (non-ANA FCDC), are considered indolent tumors with very low mortality. Hence, it is crucial to analyze the subgroup of these patients who die of disease (DOD) in order to identify clinicopathologic features predictive of disease-specific mortality. METHODS: All non-ANA FCDC operated at a tertiary cancer center between 1985 and 2010 who were DOD were identified and submitted to a meticulous clinicopathologic analysis...
November 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27467101/a-unique-case-of-bilateral-h%C3%A3-rthle-cell-adenoma-in-an-adolescent
#17
Elna Kochummen, Schuyler Tong, Vatcharapan Umpaichitra, Vivian L Chin
BACKGROUND: Hürthle cell (HC) neoplasms are rare among pediatric thyroid cancers. HC adenomas (HCA) are typically benign and localized unilaterally without recurrence, and they are thus treated by hemithyroidectomy. HC carcinomas (HCC) can be bilateral and are more aggressive, necessitating total thyroidectomy. Diagnosis relies upon surgical histopathology demonstrating invasion for classification as HCC or lack of invasion in HCA, since fine needle aspiration fails to differentiate between the two...
July 29, 2016: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/27458244/pvalb-diminishes-ca2-and-alters-mitochondrial-features-in-follicular-thyroid-carcinoma-cells-through-akt-gsk3%C3%AE-pathway
#18
Thais Biude Mendes, Bruno Heidi Nozima, Alexandre Budu, Rodrigo Barbosa de Souza, Marcia Helena Braga Catroxo, Rosana Delcelo, Marcos Leoni Gazarini, Janete Maria Cerutti
We have identified previously a panel of markers (C1orf24, ITM1 and PVALB) that can help to discriminate benign from malignant thyroid lesions. C1orf24 and ITM1 are specifically helpful for detecting a wide range of thyroid carcinomas, and PVALB is particularly valuable for detecting the benign Hürthle cell adenoma. Although these markers may ultimately help patient care, the current understanding of their biological functions remains largely unknown. In this article, we investigated whether PVALB is critical for the acquisition of Hürthle cell features and explored the molecular mechanism underlying the phenotypic changes...
September 2016: Endocrine-related Cancer
https://www.readbyqxmd.com/read/27392538/a-phase-ii-trial-of-valproic-acid-in-patients-with-advanced-radioiodine-resistant-thyroid-cancers-of-follicular-cell-origin
#19
Naris Nilubol, Roxanne Merkel, Lily Yang, Dhaval Patel, James C Reynolds, Samira M Sadowski, Vladimir Neychev, Electron Kebebew
OBJECTIVE: Valproic acid (VA) is a histone deacetylase (HDAC) inhibitor that has antiproliferative effects on several types of cancer, including thyroid cancer. In addition, VA has been reported to upregulate the sodium-iodine symporter in thyroid cancer cells and increases radioiodine uptake in preclinical studies. The aim of this study was to assess the antiproliferative effects of VA and to evaluate if VA can increase the radioiodine uptake in patients with advanced, radioiodine-negative thyroid cancer...
January 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/27385138/malignancy-risk-of-oncocytic-changes-in-thyroid-nodules-who-should-we-offer-surgery-to
#20
COMPARATIVE STUDY
Pinar Yazici, Banu Yilmaz, Emre Bozkurt, Mehmet Mihmanli, Mehmet Uludag
Background Oncocytic (Hürthle) cell in fine-needle aspiration biopsy (FNAB) remains challenging for surgeons. Surgical treatment is recommended for oncocytic change in FNAB, since it can sometimes be a struggle to determine the nature of thyroid nodules. We aimed to investigate the clinical significance of oncocytic changes in FNAB in terms of management of patients. Methods The FNAB samples of 172 patients with thyroid nodules were reviewed. Of these, 39 patients with cytologic findings of oncocytic changes on FNAB [POC: predominance of oncocytic cells; SFON-H: suspicious for follicular or oncocytic neoplasm (Hürthle cell type), SM-O: suspicious for malignancy-papillary or follicular carcinoma; oncocytic variant)] were included...
February 2016: Acta Chirurgica Belgica
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