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Hurthle cell carcinoma

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https://www.readbyqxmd.com/read/28554832/evolution-of-the-histologic-classification-of-thyroid-neoplasms-and-its-impact-on-clinical-management
#1
REVIEW
B Xu, R Ghossein
The vast majority of low grade follicular cell derived thyroid carcinomas follows an indolent clinical course and is associated with very low mortality. Risk stratification using multiple clinical and pathologic characteristics has become the standard of care to guide appropriate management and avoid overtreatment. Over the past few decades, the field of thyroid pathology has witnessed several major changes that significantly impacted upon patients' care. These are: 1) The reclassification of non-invasive encapsulated follicular variant of papillary thyroid carcinoma as noninvasive follicular thyroid neoplasm with papillary-like nuclear features; 2) the diagnosis of Hurthle cell carcinoma based on the presence of capsular and vascular invasion; 3) a detailed definition of poorly differentiated thyroid carcinoma, taking into consideration mitosis and necrosis; and 4) the emphasis on a detailed pathologic analysis such as the extent of vascular invasion and extrathyroidal extension...
May 18, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28545571/survival-and-prognostic-factors-for-survival-cancer-specific-survival-and-disease-free-interval-in-239-patients-with-hurthle-cell-carcinoma-a-single-center-experience
#2
Branisav Oluic, Ivan Paunovic, Zlatibor Loncar, Vladimir Djukic, Aleksandar Diklic, Milan Jovanovic, Zeljko Garabinovic, Nikola Slijepcevic, Branislav Rovcanin, Dusan Micic, Aleksandar Filipovic, Vladan Zivaljevic
BACKGROUND: Hurthle cell carcinoma makes up 3 to 5% of all thyroid cancers and is considered to be a true rarity. The aim of our study was to analyze clinical characteristics and survival rates of patients with Hurthle cell carcinoma. METHODS: Clinical data regarding basic demographic characteristics, tumor grade, type of surgical treatment and vital status were collected. Methods of descriptive statistics and Kaplan-Meier survival curves were used for statistical analysis...
May 25, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28533654/psma-expression-in-multinodular-thyroid-neoplasm-on-simultaneous-ga-68-psma-pet-mri
#3
Amarnath Jena, Shuaib Zaidi, Vikas Kashyap, Abhishek Jha, Sangeeta Taneja
PSMA PET is increasingly being used in imaging of recurrent prostate carcinoma. A case with suspected recurrent Prostate carcinoma (PCa), raised PSA (Prostate specific antigen) and suspected spinal metastases was referred for whole body Ga-68-PSMA PET/MRI. The study revealed PSMA avid recurrent prostate mass and extensive osseous metastases. Abnormal PSMA uptake in the thyroid gland prompted USG-guided FNAC which revealed Hurthle cell neoplasm. Histopathological examination (HPE) of excised gland showed multiple Hurthle cell adenomas in both lobes of thyroid along with foci of papillary thyroid carcinoma which on immunohistochemistry were thyroglobulin positive and PSA negative...
April 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28523326/hashimoto-s-thyroiditis-associated-with-thyroid-adenoma-with-h%C3%A3-rthle-cells-case-report
#4
Mihaela Stanciu, Liana Gabriela Bera, Mihaela Popescu, Florin Grosu, Florina Ligia Popa
Chronic thyroiditis may present a focal lesion, often-palpable abnormality, simulating nodular disease. The number and morphology of the Hürthle cells (HC) vary in the thyroid aspirate. Distinguishing between neoplastic and non-neoplastic HC lesions is difficult when using the fine-needle aspiration cytology (FNAC). We present the case of a 46-year-old female with a large right nodular goiter and hypothyroidism and high titer of anti-thyroid peroxidase antibody (TPO). The thyroid ultrasound showed a large well-defined nodule (more than 6...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28507839/issues-in-managing-hurthle-cell-carcinoma-of-thyroid-a-case-report
#5
Patricia Tai, Martin Korzeniowski, Evgeny Sadikov, Kurian Joseph, Angus Kirby, Jon Tonita, Aamer Mahmud
A 61-year-old woman noticed a right neck lump in October 2001. Fine needle aspiration showed follicular neoplasm, adenoma versus carcinoma. The ultrasound scan showed a solid mass of maximum dimension of 3.7 cm. She had a right thyroid lobectomy and isthmectomy in January 2002 (first surgery). The tissue specimen showed a 4.5 cm Hurthle cell carcinoma (HCC) with vascular invasion. There were no capsular invasion, extra-thyroidal extension, or margin involvement. A completion left lobectomy (second surgery) was performed two weeks later...
April 14, 2017: Curēus
https://www.readbyqxmd.com/read/28488725/a-rare-case-of-marine-lenhart-syndrome-with-unilateral-endocrine-orbitopathy-and-h%C3%A3-rthle-cell-carcinoma
#6
Susanne Stanzel, Peter Gyürüs, Ewald Kresnik, Reingard Aigner
No abstract text is available yet for this article.
May 10, 2017: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/28444500/metastatic-follicular-thyroid-carcinoma-and-the-primary-thyroid-gross-examination-institutional-review-of-cases-from-1990-to-2015
#7
Krzysztof Glomski, Vania Nosé, William C Faquin, Peter M Sadow
The diagnosis of follicular-patterned carcinomas, including follicular thyroid carcinoma, oncocytic (Hürthle cell) carcinoma, and the encapsulated follicular variant of papillary thyroid carcinoma, requires evidence of capsular and/or vascular invasion. With minimally invasive carcinomas classified often within less than a millimeter of tissue segregating them from adenomas and non-invasive follicular thyroid neoplasms with papillary-like nuclear features, opinions vary internationally over how much of the capsule to submit in order to deem it well enough represented, considering that even if grossly entirely submitted in microcassettes, without leveling through each tissue block, the capsule is truly never entirely examined microscopically...
June 2017: Endocrine Pathology
https://www.readbyqxmd.com/read/28410848/improving-access-to-image-guided-procedures-at-an-integrated-rural-critical-access-hospital-ultrasound-guided-thyroid-biopsy-program
#8
Thang Q Le, Yadiel Sánchez, Alexander S Misono, Sanjay Saini, Anand M Prabhakar
PURPOSE: Critical access hospitals face difficulty providing all services locally and may need to refer patients off-site for additional care. Providing on-site minimally invasive biopsies, may obviate visits to tertiary or quaternary care centers. This study aims to assess feasibility and outcomes of an ultrasound-guided thyroid biopsy program in a critical access hospital. METHODS: In this HIPAA compliant, IRB approved study, the Interventional Radiology (IR) database of a 19-bed, island, rural, critical access hospital without onsite pathology services affiliated with our quaternary care institution was retrospectively reviewed to identify all thyroid biopsies that were performed on site since inception of the service in April 2014 through August 2016...
February 16, 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/28407624/risk-of-malignancy-and-risk-of-neoplasia-in-the-bethesda-indeterminate-categories-study-on-4-532-thyroid-fine-needle-aspirations-from-a-single-institution-in-india
#9
Swati Mahajan, Radhika Srinivasan, Arvind Rajwanshi, Bishan Radotra, Naresh Panda, Pranab Dey, Nalini Gupta, Raje Nijhawan
OBJECTIVES: To determine the frequency of category 3 (atypia of undetermined significance [AUS]/follicular lesion of undetermined significance [FLUS]), category 4 (follicular neoplasm), and category 5 (suspicious for malignancy) of The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC), the risk of malignancy (ROM) and the risk of neoplasia (RON) in these categories. STUDY DESIGN: A retrospective 6-year audit of 4,532 thyroid fine-needle aspirations (FNA) reported as per the TBSRTC from a single institution with cytohistological correlation in 335 cases...
2017: Acta Cytologica
https://www.readbyqxmd.com/read/28261999/cytological-evaluation-by-fine-needle-aspiration-biopsy-of-incidental-focal-increased-fluorodeoxyglucose-uptake-in-thyroid-on-positron-emission-tomography-scan
#10
Yanchun Li, Min Cui, Nami Azar, Dean Nakamoto, Claire W Michael
BACKGROUND: With the increased use of whole body fluorodeoxyglucose positron emission tomography (PET) scan for staging/restaging or primary diagnosis of neoplasia, thyroid incidentalomas have become more common. The limited reports of PET-positive thyroid incidentalomas showed incidence of malignancy ranging from 14 to 66%, and there is discrepancy in terms of the diagnostic significance of the standard uptake value (SUV) value. METHODS: This is a retrospective study of 20 PET incidentalomas which had cytological evaluation from October 2009 to February 2015 at a tertiary care university medical center, M:F = 8:12...
June 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28214214/diagnostic-utility-of-ck19-and-cd56-in-the-differentiation-of-thyroid-papillary-carcinoma-from-its-mimics
#11
Nehal S Abouhashem, Suzan M Talaat
BACKGROUND: Papillary Thyroid Carcinoma (PTC) is the most common type of malignant thyroid tumors. The main diagnostic clue of PTC is the presence of its characteristic nuclear features. Yet, the focal presence of these features in other thyroid lesions causes a diagnostic dilemma. AIM: To evaluate Cytokeratin 19 (CK19) and CD56 immunostains as useful diagnostic markers in distinguishing papillary thyroid carcinoma from other mimicking thyroid lesions. METHODS: Eighty cases of different thyroid lesions were submitted for immunohistochemical staining of CK19 and CD56...
January 22, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28028337/thyroid-fnac-containing-h%C3%A3-rthle-cells-and-h%C3%A3-rthle-like-cells-a-study-of-128-cases
#12
Aylin Yazgan, Serdar Balci, Nazmiye Dincer, Pamir Eren Ersoy, Dilek Tuzun, Reyhan Ersoy, Cigdem Irkkan, Bekir Cakir, Gulnur Guler
AIM: It is a diagnostic challenge to differentiate benign and malignant cytology in the presence of Hürthle cells. In our previous study, it was determined that in fine needle aspirations (FNA), the malignancy outcome of the Hürthle cells containing group tend to be papillary thyroid carcinoma (PTC) in a higher percentage. The most common misinterpretation is caused by PTC cells with large cytoplasm-like Hürthle cells. The aim of this study is to predict histologic outcome of the nodules, which have Hürthle cells in FNA according to cytological, clinical features, and BRAF(V600E) mutation status...
October 2016: Journal of Cytology
https://www.readbyqxmd.com/read/27943373/most-thyroid-cancers-detected-by-sonography-lack-intranodular-vascularity-on-color-doppler-imaging-review-of-the-literature-and-sonographic-pathologic-correlations-for-698-thyroid-neoplasms
#13
Grace C H Yang, Karen O Fried
OBJECTIVES: This study investigated the controversy of whether hypervascularity on color Doppler sonography correlates with thyroid malignancy by reviewing the literature and sonographic-pathologic correlation. METHODS: Over a 20-year period, 698 thyroid nodules had color Doppler and histopathologic data. Intranodular vascularity was graded 0 to 3+, and histopathologic findings were recorded. RESULTS: The data were collected from 698 patients (557 women and 141 men) with a mean age of 48 years (range, 16-87 years)...
December 1, 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/27929675/imaging-surveillance-in-patients-after-a-benign-fine-needle-aspiration-biopsy-of-the-thyroid-associated-cost-and-incidence-of-subsequent-cancer
#14
David J S Becker-Weidman, Neil Malhotra, David F Reilly, Naveen Selvam, Laurence Parker, Levon N Nazarian
OBJECTIVE: The objective of our study was to determine patterns and cost of imaging tumor surveillance in patients after a benign fine-needle aspiration (FNA) biopsy of the thyroid in a large teaching hospital as well as the rate of subsequent cancer detection. MATERIALS AND METHODS: This cohort study was approved by the appropriate institutional review board and complied with HIPAA. All patients who had a benign thyroid FNA biopsy between January 1, 1999, and December 31, 2003, were identified from an institutional pathology database...
February 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27885512/clinicopathological-features-of-thyroid-cancer-in-the-elderly-compared-to-younger-counterparts-single-center-experience
#15
F D Dellal, D Özdemir, A A Tam, H Baser, H Tatli Dogan, O Parlak, R Ersoy, B Cakir
PURPOSE: The incidence of thyroid cancer is increased in elderly patients. It tends to be larger and have more aggressive characteristics in these patients. Our aim was to compare features of thyroid carcinoma in geriatric and non-geriatric patients. METHODS: In total, 933 patients with thyroid cancer were retrospectively reviewed. Thyroid functions, ultrasonography features of malignant nodules, cytological and histopathological findings and the rates of recurrence and persistence were compared in patients ≥65 and <65 years old...
May 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/27856495/clinical-outcomes-of-a-cohort-of-patients-with-central-nervous-system-metastases-from-thyroid-cancer
#16
Joana Simões-Pereira, Daniel Macedo, Maria João Bugalho
INTRODUCTION: Metastases to central nervous system (M1-CNS) are rarely reported in thyroid cancer (TC) patients. We aimed to characterize patients with M1-CNS from TC followed in our department. METHODS: Review of the medical records of 27 patients with TC-related M1-CNS. RESULTS: Mean age at TC diagnosis was 56.9 ± 19.1 years. Papillary TC (55.6%) was the commonest histological type, followed by poorly differentiated (18.5%), medullary (11...
November 2016: Endocrine Connections
https://www.readbyqxmd.com/read/27853381/h%C3%A3-rthle-cell-carcinoma-current-perspectives
#17
REVIEW
Sara Ahmadi, Michael Stang, Xiaoyin Sara Jiang, Julie Ann Sosa
Hürthle cell carcinoma (HCC) can present either as a minimally invasive or as a widely invasive tumor. HCC generally has a more aggressive clinical behavior compared with the other differentiated thyroid cancers, and it is associated with a higher rate of distant metastases. Minimally invasive HCC demonstrates much less aggressive behavior; lesions <4 cm can be treated with thyroid lobectomy alone, and without radioactive iodine (RAI). HCC has been observed to be less iodine-avid compared with other differentiated thyroid cancers; however, recent data have demonstrated improved survival with RAI use in patients with HCC >2 cm and those with nodal and distant metastases...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27816963/defective-ciliogenesis-in-thyroid-h%C3%A3-rthle-cell-tumors-is-associated-with-increased-autophagy
#18
Junguee Lee, Shinae Yi, Yea Eun Kang, Joon Young Chang, Jung Tae Kim, Hae Joung Sul, Jong Ok Kim, Jin Man Kim, Joon Kim, Anna Maria Porcelli, Koon Soon Kim, Minho Shong
Primary cilia are found in the apical membrane of thyrocytes, where they may play a role in the maintenance of follicular homeostasis. In this study, we examined the distribution of primary cilia in the human thyroid cancer to address the involvement of abnormal ciliogenesis in different thyroid cancers. We examined 92 human thyroid tissues, including nodular hyperplasia, Hashimoto's thyroiditis, follicular tumor, Hürthle cell tumor, and papillary carcinoma to observe the distribution of primary cilia. The distribution and length of primary cilia facing the follicular lumen were uniform across variable-sized follicles in the normal thyroid gland...
November 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/27728172/diffuse-toxic-goiter-and-coexisting-hurthle-cell-carcinoma-of-thyroid-presenting-as-lower-limb-weakness-from-mononeuritis-multiplex
#19
Kadhiravan
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27679545/functional-polymorphisms-in-antioxidant-genes-in-hurthle-cell-thyroid-neoplasm-an-association-of-gpx1-polymorphism-and-recurrent-hurthle-cell-thyroid-carcinoma
#20
Blaz Krhin, Katja Goricar, Barbara Gazic, Vita Dolzan, Nikola Besic
BACKGROUND: Hurthle cells of the thyroid gland are very rich in mitochondria and oxidative enzymes. As a high level oxidative metabolism may lead to higher level of oxidative stress and can be associated with an increased risk for cancer, we investigated whether common functional polymorphisms in antioxidant genes (SOD2, CAT, GPX, GSTP1, GSTM1 and GSTT1) are associated with the development or clinical course of Hurthle cell thyroid carcinoma (HCTC). METHODS: A retrospective study was performed in 139 patients treated by thyroid surgery for a Hurthle cell neoplasm...
September 1, 2016: Radiology and Oncology
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