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Hurthle cell carcinoma

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January 2016: Journal of the Association of Physicians of India
Blaz Krhin, Katja Goricar, Barbara Gazic, Vita Dolzan, Nikola Besic
BACKGROUND: Hurthle cells of the thyroid gland are very rich in mitochondria and oxidative enzymes. As a high level oxidative metabolism may lead to higher level of oxidative stress and can be associated with an increased risk for cancer, we investigated whether common functional polymorphisms in antioxidant genes (SOD2, CAT, GPX, GSTP1, GSTM1 and GSTT1) are associated with the development or clinical course of Hurthle cell thyroid carcinoma (HCTC). METHODS: A retrospective study was performed in 139 patients treated by thyroid surgery for a Hurthle cell neoplasm...
September 1, 2016: Radiology and Oncology
Andrej Vogrin, Hana Besic, Nikola Besic, Maja Marolt Music
BACKGROUND: Preoperative ultrasound (US) evaluation of central and lateral neck compartments is recommended for all patients undergoing a thyroidectomy for malignant or suspicious for malignancy cytologic or molecular findings. Our aim was to find out how frequent was recurrence in regional lymph nodes in patients with follicular or Hürthle cell neoplasm and usefulness of preoperative neck US investigation in patients with neoplasm. PATIENTS AND METHODS: Altogether 737 patients were surgically treated because of follicular or Hürthle cell neoplasms from 1995 to 2014 at our cancer comprehensive center, among them 207 patients (163 females, 44 males; mean age 52 years) had thyroid carcinoma...
September 1, 2016: Radiology and Oncology
Jieun Koh, Eun-Kyung Kim, Ji-Ye Kim, Jin Young Kwak, Jung Hyun Yoon, Hee Jung Moon
The aim of the study described here was to compare ultrasound features, pathologic characteristics and prognoses of the follicular variant of papillary thyroid carcinoma (FVPTC) according to cytology results. Eighty-seven FVPTCs were classified according to the first cytology results as the surgery group (n = 66, follicular neoplasm/Hürthle cell neoplasm, suspicious for malignancy and malignancy) and the indeterminate group (n = 21, non-diagnostic and benign), for whom the management was follow-up. The indeterminate group had a longer mean interval to surgery (p = 0...
September 19, 2016: Ultrasound in Medicine & Biology
Daniel G Pankratz, Zhanzhi Hu, Su Yeon Kim, Robert J Monroe, Mei G Wong, S Thomas Traweek, Richard T Kloos, P Sean Walsh, Giulia C Kennedy
BACKGROUND: To demonstrate the analytical validity of an RNA classifier for medullary thyroid carcinoma (MTC). METHODS: Fresh-frozen tissue specimens were obtained from commercial sources, and MTC diagnoses were confirmed by histopathology review. De-identified patient fine-needle aspiration biopsies (FNABs) and whole blood from normal donors were obtained. Total RNA was extracted, amplified, and hybridized to custom microarrays for gene expression analysis. Gene expression data was normalized and classified via a machine learning algorithm...
September 7, 2016: Thyroid: Official Journal of the American Thyroid Association
Rok Petric, Barbara Gazic, Katja Goricar, Vita Dolzan, Radan Dzodic, Nikola Besic
Background. Hürthle cell thyroid carcinoma (HCTC) is a rare type of thyroid carcinoma. In the present study, we investigated whether the expression of miRNAs of interest is associated with the occurrence of metastases in patients with HCTC. Materials and Methods. In 39 patients with HCTC (22 with nonmetastatic and 17 with regional or distant metastatic disease), the expression levels of six miRNAs (miR-138, miR-183, miR-221, miR-222, miR-768-3p, and miR-885-5p) and U6 snRNA as endogenous control were determined in FFPE samples of primary tumor and normal thyroid tissue using TaqMan miRNA assays...
2016: International Journal of Endocrinology
Amandine Crombé, Xavier Buy, Yann Godbert, Nicolas Alberti, Michèle Kind, Françoise Bonichon, Jean Palussière
An 82-year-old man, who was diagnosed in 2002 with an oncocytic (Hürthle cell) thyroid carcinoma, was initially treated by local surgery and was refractory to radioiodine treatment. The patient had successive secondary recurrences from 2006 onwards. Metastases were suspected due to an elevation of thyroglobulin in serum. Hypermetabolic nodules were targeted using FDG PET as well as CT-guided radiofrequency ablations. Thyroglobulin levels decreased following each procedure. 10 years later, tolerance and efficacy are excellent; 23 lung metastases have been treated during 11 sessions without current relapse...
August 8, 2016: Cardiovascular and Interventional Radiology
Bin Xu, Tihana Ibrahimpasic, Laura Y Wang, Mona Sabra, Jocelyn C Migliacci, R Michael Tuttle, Ian Ganly, Ronald Ghossein
BACKGROUND: The vast majority of thyroid cancer, in particular the non-anaplastic follicular cell-derived thyroid carcinomas (non-ANA FCDCs), are considered indolent tumors with very low mortality. Hence, it is crucial to analyze the subgroup of these patients who died of disease (DOD) in order to identify clinico-pathologic features predictive of disease specific mortality. METHODS: All non-ANA FCDCs operated at a tertiary cancer center between 1985 and 2010 who were DOD were identified and submitted to a meticulous clinico-pathologic analysis...
August 1, 2016: Thyroid: Official Journal of the American Thyroid Association
Elna Kochummen, Schuyler Tong, Vatcharapan Umpaichitra, Vivian L Chin
BACKGROUND: Hürthle cell (HC) neoplasms are rare among pediatric thyroid cancers. HC adenomas (HCA) are typically benign and localized unilaterally without recurrence, and they are thus treated by hemithyroidectomy. HC carcinomas (HCC) can be bilateral and are more aggressive, necessitating total thyroidectomy. Diagnosis relies upon surgical histopathology demonstrating invasion for classification as HCC or lack of invasion in HCA, since fine needle aspiration fails to differentiate between the two...
July 29, 2016: Hormone Research in Pædiatrics
Thais Biude Mendes, Bruno Heidi Nozima, Alexandre Budu, Rodrigo Barbosa de Souza, Marcia Helena Braga Catroxo, Rosana Delcelo, Marcos Leoni Gazarini, Janete Maria Cerutti
We have identified previously a panel of markers (C1orf24, ITM1 and PVALB) that can help to discriminate benign from malignant thyroid lesions. C1orf24 and ITM1 are specifically helpful for detecting a wide range of thyroid carcinomas, and PVALB is particularly valuable for detecting the benign Hürthle cell adenoma. Although these markers may ultimately help patient care, the current understanding of their biological functions remains largely unknown. In this article, we investigated whether PVALB is critical for the acquisition of Hürthle cell features and explored the molecular mechanism underlying the phenotypic changes...
September 2016: Endocrine-related Cancer
Naris Nilubol, Roxanne Merkel, Lily Yang, Dhaval Patel, James C Reynolds, Samira M Sadowski, Vladimir Neychev, Electron Kebebew
OBJECTIVE: Valproic acid (VA) is a histone deacetylase (HDAC) inhibitor that has antiproliferative effects on several types of cancer, including thyroid cancer. In addition, VA has been reported to upregulate the sodium-iodine symporter in thyroid cancer cells and increases radioiodine uptake in preclinical studies. The aim of this study was to assess the antiproliferative effects of VA and to evaluate if VA can increase the radioiodine uptake in patients with advanced, radioiodine-negative thyroid cancer...
July 9, 2016: Clinical Endocrinology
Pinar Yazici, Banu Yilmaz, Emre Bozkurt, Mehmet Mihmanli, Mehmet Uludag
Background Oncocytic (Hürthle) cell in fine-needle aspiration biopsy (FNAB) remains challenging for surgeons. Surgical treatment is recommended for oncocytic change in FNAB, since it can sometimes be a struggle to determine the nature of thyroid nodules. We aimed to investigate the clinical significance of oncocytic changes in FNAB in terms of management of patients. Methods The FNAB samples of 172 patients with thyroid nodules were reviewed. Of these, 39 patients with cytologic findings of oncocytic changes on FNAB [POC: predominance of oncocytic cells; SFON-H: suspicious for follicular or oncocytic neoplasm (Hürthle cell type), SM-O: suspicious for malignancy-papillary or follicular carcinoma; oncocytic variant)] were included...
February 2016: Acta Chirurgica Belgica
Andrew A Renshaw, Edwin W Gould
BACKGROUND: To the authors' knowledge, the impact of specific cytologic patterns in thyroid fine-needle aspiration (FNA) for follicular and Hurthle cell carcinoma is not known. METHODS: The results of all thyroid FNAs performed from 1997 through 2015 with corresponding resections of follicular and Hurthle cell carcinomas were reviewed. RESULTS: A total of 24 follicular carcinomas and 35 Hurthle cell carcinomas were identified. All FNA specimens from follicular carcinomas had a microfollicular component (3 of which were noted only in 3-dimensional groups), but only 18 cases (75%) had cytologic atypia, which most commonly consisted of enlarged nuclei with slightly pale chromatin...
June 20, 2016: Cancer Cytopathology
Nermin Hrnčić, Amna Goga, Selma Hrnčić, Marijana Filipovska-Mušanović, Haris Hatibović, Ðenad Hodžić
Aim To determine frequency and type of thyroid cancer (TC) as well as gender and age distribution of patients operated at the Department of Ear, Nose and Throat (ENT), Cantonal Hospital Zenica, Bosnia and Herzegovina. Methods A retrospective analysis of data obtained from an operating protocol and disease history of patients operated in the eightyear period (2007- 2014) was made according to the frequency and type of thyroid cancer, as well as age and gender of the patients. χ2 test was used for statistical with p<0...
August 1, 2016: Medicinski Glasnik
Bidish K Patel, Arun Roy, Bhawana A Badhe, Neelaiah Siddaraju
Among primary thyroid neoplasms, papillary thyroid carcinoma (PTC) and primary thyroid lymphoma (PTL) are known to coexist and are pathogenetically linked with Hashimoto's thyroiditis (HT). However, HT occurring in association with medullary thyroid carcinoma (MTC) is rarely documented. We report here an interesting case. A 34-year-old female with a solitary thyroid nodule underwent fine needle aspiration cytology (FNAC) that was interpreted as "MTC with admixed reactive lymphoid cells, derived possibly from a pretracheal lymph node...
April 2016: Journal of Cytology
Christa L Jillard, Linda Youngwirth, Randall P Scheri, Sanziana Roman, Julie A Sosa
BACKGROUND: Hürthle cell carcinoma (HCC) is not typically iodine avid, raising questions regarding postoperative use of radioactive iodine (RAI). The aims of this study were to describe current practice patterns regarding the use of RAI for HCC and to assess its association with survival. METHODS: The National Cancer Data Base 1998-2006 was queried for all patients with HCC who underwent total thyroidectomy. Inclusion was limited to T1 tumors with N1/M1 disease, and T2-4 tumors with any N/M disease...
July 2016: Thyroid: Official Journal of the American Thyroid Association
Dalia Rifaat Al-Sharaky, Sheren Fouad Younes
INTRODUCTION: Diagnosing follicular-patterned thyroid neoplasm can be quiet challenging in some cases, where an immunohistochemical profiling becomes mandatory. Galectin-3 may be a helpful tool for classical PTC diagnosis, but it cannot be considered as a diagnostic marker of malignancy. Glypican-3, in contrast, is not thoroughly studied in thyroid neoplasms. AIM: Determine the sensitivity and specificity of galectin-3 and glypican-3 in diagnosing thyroid carcinoma and follicular-patterned thyroid carcinoma...
March 2016: Journal of Clinical and Diagnostic Research: JCDR
Massimo Bongiovanni, Silvia Uccella, Luca Giovanella, Francesca Molinari, Milo Frattini, Gianlorenzo Dionigi, Eliana Piantanida, Antoine Nobile, Fausto Sessa, Stefano La Rosa
Thyroid implants in the soft tissue of the neck are very rare findings of traumatic, iatrogenic, or neoplastic origins. We describe the clinico-pathological and molecular analysis of three cases with an initial diagnosis of follicular adenoma, Hürthle cell variant (FA-HCT), which developed cervical thyroid implants at 60, 59, and 36 months after thyroid surgery, followed by further neck recurrences, and, eventually, by distant metastases. A systematic review of all histopathological samples of both the primary lesions and the neck implants was performed...
April 23, 2016: Endocrine Pathology
Rupendra T Shrestha, James V Hennessey
BACKGROUND: The atypia of undetermined significance or follicular lesion of undetermined significance (AUS/FLUS) category in the Bethesda System of reporting thyroid fine-needle aspiration (FNA) includes various cytological findings considered to have a low risk of malignancy. It is still unclear if any particular subset of the cytological findings within this category carries a higher risk for malignancy requiring a more aggressive treatment plan. METHODS: We reviewed 221 AUS/FLUS FNAs performed between January of 2006 and May of 2012...
June 2016: Diagnostic Cytopathology
Lutske Lodewijk, Wouter P Kluijfhout, Jakob W Kist, Inge Stegeman, John T M Plukker, Els J Nieveen van Dijkum, H Jaap Bonjer, Nicole D Bouvy, Abbey Schepers, Johannes H W de Wilt, Romana T Netea-Maier, Jos A van der Hage, Jacobus W A Burger, Gavin Ho, Wayne S Lee, Wen T Shen, Anna Aronova, Rasa Zarnegar, Cassandre Benay, Elliot J Mitmaker, Mark S Sywak, Ahmad M Aniss, Schelto Kruijff, Benjamin James, Raymon H Grogan, Laurent Brunaud, Guillaume Hoch, Chiara Pandolfi, Daniel T Ruan, Michael D Jones, Marlon A Guerrero, Gerlof D Valk, Inne H M Borel Rinkes, Menno R Vriens
PURPOSE: Traditionally, total thyroidectomy has been advocated for patients with tumors larger than 1 cm. However, according to the ATA and NCCN guidelines (2015, USA), patients with tumors up to 4 cm are now eligible for lobectomy. A rationale for adhering to total thyroidectomy might be the presence of contralateral carcinomas. The purpose of this study was to describe the characteristics of contralateral carcinomas in patients with differentiated thyroid cancer (DTC) larger than 1 cm...
May 2016: Langenbeck's Archives of Surgery
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