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diaphragmatic hernia

Yoh Asahi, Shohei Honda, Tadao Okada, Hisayuki Miyagi, Makoto Kaneda, Akihiro Iguchi, Kichizo Kaga, Akinobu Taketomi
Although diaphragmatic hernia (DH) may be congenital, posttraumatic, or iatrogenic, DHs after diaphragmatic surgery are rarely reported in the literature. This report describes the rare case of a 14-year-old girl complicated by iatrogenic DH following the biopsy of granulomatous lesions of the left diaphragm, when a mediastinal mixed germ cell tumor was extirpated. Plain computed tomography (CT) with swallowing of GastrografinTM was useful for the diagnosis of this disorder. The patient presented to our hospital with frequent epigastric pain and vomiting 11 months after the original surgery...
May 2018: Case Reports in Gastroenterology
Florian Friedmacher, Mikko P Pakarinen, Risto J Rintala
Despite a growing interest to clinicians and scientists, there is no comprehensive study that examines the global research activity on congenital diaphragmatic hernia (CDH). A search strategy for the Web of Science™ database was designed to identify scientific CDH publications. Research output of countries, institutions, individual authors, and collaborative networks was analyzed. Semi-qualitative research measures including citation rate and h-index were assessed. Choropleth mapping and network diagrams were employed to visualize results...
July 17, 2018: Pediatric Surgery International
M Weis, S Hoffmann, C Henzler, C Weiss, S O Schoenberg, R Schaffelder, T Schaible, K W Neff
PURPOSE: To evaluate liver-herniation as individual parameter on outcome in children with congenital diaphragmatic hernia. MATERIALS AND METHODS: In a retrospective matched-pair analysis based on observed to expected fetal lung volume (o/e FLV), birth weight, gestational age at time-point of examination, status of tracheal occlusion therapy and side of the defect the individual impact of liver-herniation on survival, need for extracorporeal membrane oxygenation (ECMO) therapy and chronic lung disease (CLD) was investigated...
August 2018: European Journal of Radiology
Ali Kamran, Benjamin Zendejas, Farokh R Demehri, Bharath Nath, David Zurakowski, Charles J Smithers
PURPOSE: To identify technical modifications concerning factors that may lower the risk of recurrence following thoracoscopic repair of congenital diaphragmatic hernia (CDH). METHODS: All CDH patients who underwent thoracoscopic repair from April 2003 to September 2017 were retrospectively reviewed. Some of the more recently treated patients underwent technically modified repairs with underlay and overlay buttresses. RESULTS: Sixty-eight patients underwent thoracoscopic repair of a diaphragmatic hernia that presented either neonatally (n = 52) or beyond the neonatal period (>1 month) (n = 16)...
April 8, 2018: Journal of Pediatric Surgery
Marisol Herrera-Rivero, Rong Zhang, Stefanie Heilmann-Heimbach, Andreas Mueller, Soyhan Bagci, Till Dresbach, Lukas Schröder, Stefan Holdenrieder, Heiko M Reutter, Florian Kipfmueller
Pulmonary hypertension (PH) contributes to high mortality in congenital diaphragmatic hernia (CDH). A better understanding of the regulatory mechanisms underlying the pathology in CDH might allow the identification of prognostic biomarkers and potential therapeutic targets. We report the results from an expression profiling of circulating microRNAs (miRNAs) in direct post-pulmonary blood flow of 18 CDH newborns. Seven miRNAs differentially expressed in children that either died or developed chronic lung disease (CLD) up to 28 days after birth, compared to those who survived without developing CLD during this period, were identified...
July 16, 2018: Scientific Reports
Caroline Bodi Winn, Stephen C Artim, Morgan S Jamiel, Monika A Burns, Jennifer L Haupt, James G Fox, Sureshkumar Muthupalani
A 6-y-old, intact, pair-housed male common marmoset (Callithrix jacchus) presented with acute onset dyspnea and tachypnea immediately after sedation with alfaxalone; a history of gradual weight loss initiated the examination under sedation. Thoracic radiographs revealed significant right-lung consolidation, with a vesicular gas pattern in the right caudodorsal lung field, pleural effusion, and dorsal displacement of the heart. The marmoset was euthanized due to his unstable condition and poor prognosis. At necropsy, the cranial and middle lobes of the right lung were homogenously dark red-brown, enlarged, edematous, and twisted around the longitudinal axis at the hilus...
July 16, 2018: Comparative Medicine
Eva Gatzweiler, Bernd Hoppe, Oliver Dewald, Christoph Berg, Andreas Müller, Heiko Reutter, Florian Kipfmueller
BACKGROUND: Survival of neonates with intrauterine renal insufficiency and oligo- or anhydramnios correlates with the severity of secondary pulmonary hypoplasia. Early prenatal diagnosis together with repetitive amnioinfusions and modern intensive care treatment have improved the prognosis of these neonates. Extracorporeal membrane oxygenation is an established treatment option, mainly applied to neonates with pulmonary hypoplasia caused by congenital diaphragmatic hernia. However, a few case reports of extracorporeal membrane oxygenation in neonates with lower urinary tract obstruction have been published...
July 17, 2018: Journal of Medical Case Reports
James M Tatum, Evan Alicuben, Nikolai Bildzukewicz, Kamran Samakar, Caitlin C Houghton, John C Lipham
BACKGROUND: The magnetic sphincter augmentation (MSA) device was initially implanted with minimal hiatal dissection (MHD) at the diaphragmatic hiatus. Due to concern of possible MSA device dysfunction if herniated into an occult or small hiatal hernia, and increased understanding to the role of defective crura in reflux disease, the operative procedure was changed to planned obligatory dissection (OD) of the hiatus at the time of all implantations. METHODS: Between December 2012 and September 2016, 182 patients underwent MSA implant at a single medical center and have complete records available for review through September 2017...
July 13, 2018: Surgical Endoscopy
Heidi J Murphy, Carolyn W Finch, Sarah N Taylor
Critically ill neonates who require extracorporeal life support have particular nutrition needs. These infants require prescription of aggressive, early nutrition support by knowledge providers. Understanding the unique metabolic demands and nutrition requirements of these fragile patients is paramount, particularly if additional therapies such as aggressive diuretic regimens or continuous renal replacement therapy are used concurrently. Although the American Society for Parenteral and Enteral Nutrition has published guidelines for this population, a review of each nutrition component is warranted because few studies exist specific to this population...
July 13, 2018: Nutrition in Clinical Practice
Ruchi Amin, Michelle Knezevich, Melissa Lingongo, Aniko Szabo, Ziyan Yin, Keith T Oldham, Casey M Calkins, Thomas T Sato, Marjorie J Arca
OBJECTIVE: This prospective observational study was designed to assess Pediatric Quality of Life (PedsQL) after surgical treatment for congenital diaphragmatic hernia (CDH), esophageal atresia/tracheoesophageal fistula (EA/TEF), Hirschsprung disease (HD), gastroschisis (GAS), omphalocele (OMP), and necrotizing enterocolitis (NEC). SUMMARY OF BACKGROUND DATA: Improvements in neonatal and surgical care have led to increased survival for many newborn conditions. Quality of life in these patients is seldom explored in a longitudinal manner...
July 9, 2018: Annals of Surgery
V Núñez Cerezo, M Romo Muñoz, J L Encinas, J Jiménez, M D Elorza Fernández, B Herrero, E Antolín, L Martínez Martínez, M López Santamaría
INTRODUCTION AND OBJECTIVES: The aim of this study is to identify respiratory clinic and pulmonary arterial hypertension (PAH) in congenital diaphragmatic hernia (CDH) and whether these could be predicted by prenatal measures. MATERIAL AND METHODS: We studied fetal ultrasound: Observed/expected Lung to Head Ratio (O/E LHR) and classified patients according to their outcome (group 1: O/E LHR <25%, group 2: 26-35%, group 3: 36-45%, group 4: >55%) as well as the severity of PAH (group 0: non-PAH, group 1: mild, group 2: moderate, group 3: severe) in echocardiograms at birth, 1st, 6th, 12th and 24 months of life...
April 20, 2018: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
Kengo Hattori, Shigeru Takamizawa, Yuichiro Miyake, Tomoko Hatata, Katsumi Yoshizawa, Tomoko Furukawa, Yoshiaki Kondo
BACKGROUND: Sonographic assessment before congenital diaphragmatic hernia repair has rarely been studied. OBJECTIVE: To evaluate the accuracy of preoperative ultrasound in measuring the defect size and in anticipating the presence of a rim and thereby to determine ultrasound's usefulness in informing the surgical approach for definitive repair of congenital diaphragmatic hernia. MATERIALS AND METHODS: We performed a retrospective review of the medical records of seven children with left congenital diaphragmatic hernia who had undergone ultrasound and definitive repair between 2014 and 2017 at our institution...
July 5, 2018: Pediatric Radiology
Soykan Arikan, Mehmet Baki Dogan, Ahmet Kocakusak, Feyzullah Ersoz, Serkan Sari, Yigit Duzkoylu, Ali Emre Nayci, Emre Ozoran, Emine Tozan, Turkan Dubus
A Morgagni's hernia is a congenital defect found in the anterior aspect of the diaphragm between the costal and the sternal portions of this muscle. This defect is also referred to as the space of Larrey. It has been reported that 70% of patients with Morgagni's hernia are female, 90% of the hernias are right-sided, and 92% of the hernias have hernia sacs. This type of hernia is a rare clinical entity and accounts for 3% of all surgically treated diaphragmatic hernias. There are no large retrospective or prospective studies on this topic...
June 2018: Indian Journal of Surgery
Jill L Morsberger, Heather L Short, Katherine J Baxter, Curtis Travers, Matthew S Clifton, Megan M Durham, Mehul V Raval
PURPOSE: The aim of this study was to determine long-term outcomes for congenital diaphragmatic hernia (CDH) patients including quality of life (QoL), symptom burden, reoperation rates, and health status. METHODS: A chart review and phone QoL survey were performed for patients who underwent CDH repair between 2007 and 2014 at a tertiary free-standing children's hospital. Comprehensive outcomes were collected including subsequent operations and health status. Associations with QoL were tested using Wilcoxon Rank-Sum tests and Pearson correlation coefficients...
June 18, 2018: Journal of Pediatric Surgery
G Salvatori, S Foligno, M Massoud, F Piersigilli, P Bagolan, A Dotta
BACKGROUND: Newborns with congenital diaphragmatic hernia (CDH) and esophageal atresia (EA) might experience breastfeeding difficulties. The aim of this study was to detect the prevalence of breastfeeding in newborns with CDH and EA at different time points. METHODS: We performed an epidemiological study and retrospective survey on the prevalence of breastfeeding in CDH and EA affected newborns. We identified 40 CDH and 25 EA newborns who were fed through breastfeeding procedures according to WHO categorized definitions, and compared the breastfeeding procedures at the beginning of hospitalization and at three months of life...
July 3, 2018: Italian Journal of Pediatrics
Molka Kammoun, Erika Souche, Paul Brady, Jia Ding, Nele Cosemans, Eduard Gratacos, Koen Devriendt, Elisenda Eixarch, Jan Deprest, Joris Robert Vermeesch
BACKGROUND: Congenital diaphragmatic hernia (CDH) is characterized by a defective closure figof the diaphragm occurring as an isolated defect in 60% of cases. Lung size, liver herniation and pulmonary circulation are major prognostic indices. Isolated CDH genetics is heterogeneous and poorly understood. Whether genetic lesions are also outcome determinants has never been explored. OBJECTIVES: to identify isolated CDH genetic causes, to fine map the mutational burden and to search for a correlation between the genotype and the disease severity and outcome...
July 2, 2018: Prenatal Diagnosis
Marina Domínguez Ruiz, Florence Vessières, Guillaume R Ragetly, Juan L Hernandez
OBJECTIVE To characterize and investigate potential associations between causes of pleural effusion and various clinical factors in a large cohort of affected cats. DESIGN Retrospective case series with nested cross-sectional study. ANIMALS 380 client-owned cats with a diagnosis of pleural effusion from January 1, 2009, through July 14, 2014, for which the cause of pleural effusion had been fully investigated. PROCEDURES Electronic medical records were reviewed and data collected regarding cat characteristics, clinical signs, cause of pleural effusion, treatment, and survival status at discharge from the hospital...
July 15, 2018: Journal of the American Veterinary Medical Association
Lisa Hinton, Louise Locock, Anna-May Long, Marian Knight
OBJECTIVES: To understand the experiences of parents of infants who required surgery early in life. To identify messages and training needs for the extended clinical teams caring for these families-including paediatric surgeons, neonatologists, nurses, obstetricians, midwives and sonographers. SETTING: UK-wide interview study, including England, Wales and Scotland. PARTICIPANTS: In-depth interviews were conducted with 44 parents who had a baby who underwent early abdominal surgery...
June 30, 2018: BMJ Open
Brady S Moffett, Jennifer Morris, Marianne Galati, Flor M Munoz, Ayse Akcan Arikan
BACKGROUND: Gentamicin pharmacokinetics may be altered in pediatric patients undergoing extracorporeal membrane oxygenation (ECMO). Description of gentamicin pharmacokinetics and relevant variables can improve dosing. METHODS: A retrospective population pharmacokinetic study was designed, and pediatric patients who received gentamicin while undergoing ECMO therapy over a period of 6 ½ years were included. Data collection included: patient demographics, serum creatinine, albumin, hematocrit, gentamicin dosing and serum concentrations, urine output, and ECMO circuit parameters...
June 26, 2018: Therapeutic Drug Monitoring
Hanane Bouchghoul, Oriane Marty, Virginie Fouquet, Anne-Gaël Cordier, Marie-Victoire Senat, Julien Saada, Mostafa Mokhtari, Nolwenn Le Sache, Jelena Martinovic, Alexandra Benachi
OBJECTIVE: To evaluate neonatal mortality and morbidity up to 6 months in neonates with congenital diaphragmatic hernia (CDH) with or without a hernia sac. METHODS: 72 Cases of isolated CDH were included in a retrospective single-center study between January, 2010 and December, 2016. Hernia sac was defined at the time of surgery or at postmortem examination if the neonate died before surgery. RESULTS: 17 newborns (23.6%) had a hernia sac. Survival at 6 months was significantly greater for isolated CDH with a hernia sac: 100% versus 63...
June 28, 2018: Prenatal Diagnosis
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