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https://www.readbyqxmd.com/read/29458077/reciprocal-regulation-of-the-cadherin-11-stat3-axis-by-caveolin-1-in-mouse-fibroblasts-and-lung-carcinoma-cells
#1
M Geletu, R Mohan, R Arulanandam, A Berger-Becvar, I R Nabi, P T Gunning, L Raptis
Caveolin-1 (Cav1) is an integral plasma membrane protein and a complex regulator of signal transduction. The Signal Transducer and Activator of Transcription-3 (Stat3) is activated by a number of receptor and non-receptor tyrosine kinases and is positively implicated in cancer. Despite extensive efforts, the relationship between Cav1 and Stat3 has been a matter of controversy. We previously demonstrated that engagement of E- or N-cadherin or cadherin-11 cell to cell adhesion molecules, as occurs with confluence of cultured cells, triggers a dramatic increase in the levels of tyr705 phosphorylated ie activated Stat3, by a mechanism requiring the cRac1 small GTPase...
February 16, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29457868/exploring-acceptability-of-oral-prep-prior-to-implementation-among-female-sex-workers-in-south-africa
#2
Robyn Eakle, Adam Bourne, Judie Mbogua, Nyaradzo Mutanha, Helen Rees
INTRODUCTION: Female sex workers (FSWs) are at high-risk for HIV acquisition in South Africa, where the advent of new HIV prevention and treatment interventions represent the potential to significantly impact the epidemic. This paper focuses on aspects of PrEP acceptability as a new intervention within the context of a larger service delivery programme including the simultaneous rollout of early ART. This paper explores PrEP acceptability among the FGD participants as future potential users...
February 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29457794/recon3d-enables-a-three-dimensional-view-of-gene-variation-in-human-metabolism
#3
Elizabeth Brunk, Swagatika Sahoo, Daniel C Zielinski, Ali Altunkaya, Andreas Dräger, Nathan Mih, Francesco Gatto, Avlant Nilsson, German Andres Preciat Gonzalez, Maike Kathrin Aurich, Andreas Prlić, Anand Sastry, Anna D Danielsdottir, Almut Heinken, Alberto Noronha, Peter W Rose, Stephen K Burley, Ronan M T Fleming, Jens Nielsen, Ines Thiele, Bernhard O Palsson
Genome-scale network reconstructions have helped uncover the molecular basis of metabolism. Here we present Recon3D, a computational resource that includes three-dimensional (3D) metabolite and protein structure data and enables integrated analyses of metabolic functions in humans. We use Recon3D to functionally characterize mutations associated with disease, and identify metabolic response signatures that are caused by exposure to certain drugs. Recon3D represents the most comprehensive human metabolic network model to date, accounting for 3,288 open reading frames (representing 17% of functionally annotated human genes), 13,543 metabolic reactions involving 4,140 unique metabolites, and 12,890 protein structures...
February 19, 2018: Nature Biotechnology
https://www.readbyqxmd.com/read/29457793/identifying-the-favored-mutation-in-a-positive-selective-sweep
#4
Ali Akbari, Joseph J Vitti, Arya Iranmehr, Mehrdad Bakhtiari, Pardis C Sabeti, Siavash Mirarab, Vineet Bafna
Most approaches that capture signatures of selective sweeps in population genomics data do not identify the specific mutation favored by selection. We present iSAFE (for "integrated selection of allele favored by evolution"), a method that enables researchers to accurately pinpoint the favored mutation in a large region (∼5 Mbp) by using a statistic derived solely from population genetics signals. iSAFE does not require knowledge of demography, the phenotype under selection, or functional annotations of mutations...
February 19, 2018: Nature Methods
https://www.readbyqxmd.com/read/29457707/peripheral-neurostimulation-breaks-the-shuffling-steps-patterns-in-parkinsonian-gait-a-double-blind-randomized-longitudinal-study-with-automated-mechanical-peripheral-stimulation
#5
Manuela Galli, Caterina Vicidomini, Ana F Rozin Kleiner, Laura Vacca, Veronica Cimolin, Claudia Condoluci, Fabrizio Stocchi, Maria F DE Pandis
BACKGROUND: The shuffling steps pattern is a typical feature of gait in patients affected by Parkinson's Disease (PD), which progressively reduces their quality of life, being related to the risk of falls in this population. Recently, Automated Mechanical Peripheral Stimulation (AMPS) was presented as an integrative rehabilitative treatment based on peripheral stimulation able to improve the gait spatiotemporal parameters in PD patients. AIM: To evaluate the effects of AMPS on shuffling steps pattern by analyzing the kinematic and spatio-temporal gait parameters...
February 19, 2018: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29457555/encoding-of-distributional-regularities-independent-of-markedness-evidence-from-unimpaired-speakers
#6
Matthew Goldrick
Romani, Galuzzi, Guariglia, and Goslin (Comparing phoneme frequency, age of acquisition and loss in aphasia: Implications for phonological universals. Cognitive Neuropsychology) used speech error data from individuals with acquired impairments to argue that independent from articulatory complexity, within-language distributional regularities influence the processing of sound structure in speech production. Converging evidence from unimpaired speakers is reviewed, focusing on speech errors in language production...
October 2017: Cognitive Neuropsychology
https://www.readbyqxmd.com/read/29457313/modeling-the-hematocrit-distribution-in-microcirculatory-networks-a-quantitative-evaluation-of-a-phase-separation-model
#7
Peter M Rasmussen, Timothy W Secomb, Axel R Pries
OBJECTIVE: Theoretical models are essential tools for studying microcirculatory function. Recently, the validity of a well-established phase separation model was questioned and it was claimed that it produces problematically low hematocrit predictions and lack of red cells in small diameter vessels. We conducted a quantitative evaluation of this phase separation model to establish common ground for future research. METHODS: Model predictions were validated against a comprehensive data base with measurements from four mesenteric networks...
February 19, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29457183/diabatic-potential-energy-surfaces-of-mgh-2-and-dynamic-studies-for-the-mg-3p-h-2-%C3%A2-mgh-h-reaction
#8
Jiuchuang Yuan, Di He, Shufen Wang, Maodu Chen, Keli Han
The global diabatic potential energy surfaces (PESs) of the MgH2 + system, which can be used to study the dynamics of the Mg+ (3p2 P) + H2 (X1 Σ) → MgH+ (X1 Σ+ ) + H(2 S) reaction, are structured for the first time. The diabatic PESs are correlated with the ground state 12 A' and the first excited state 22 A'. The multi-reference configuration interaction method and the VQZ basis set are used in ab initio calculations, and diabatic potential energies are calculated based on the molecular properties of the dipole moment...
February 19, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29457181/ab-initio-kinetics-of-the-hoso-2-3-o-2-%C3%A2-so-3-ho-2-reaction
#9
Tam V-T Mai, Minh V Duong, Hieu T Nguyen, Lam K Huynh
The detailed kinetic mechanism of the HOSO2 +3 O2 reaction, which plays a pivotal role in the atmospheric oxidation of SO2 , was investigated using accurate electronic structure calculations and novel statistical thermodynamic/kinetic models. Explored using the accurate composite method W1U, the detailed potential energy surface (PES) revealed that the addition of O2 to a HOSO2 radical to form the adduct (HOSO4 ) proceeds via a transition state with a slightly positive barrier (i.e., 0.7 kcal mol-1 at 0 K)...
February 19, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29456843/analysis-of-selected-policies-towards-universal-health-coverage-in-uganda-the-policy-implementation-barometer-protocol
#10
Charles Hongoro, Elizeus Rutebemberwa, Thembinkosi Twalo, Chikondi Mwendera, Mbuyiselo Douglas, Moses Mukuru, Simon Kasasa, Freddie Ssengooba
Background: Policy implementation remains an under researched area in most low and middle income countries and it is not surprising that several policies are implemented without a systematic follow up of why and how they are working or failing. This study is part of a larger project called Supporting Policy Engagement for Evidence-based Decisions (SPEED) for Universal Health Coverage in Uganda. It seeks to support policymakers monitor the implementation of vital programmes for the realisation of policy goals for Universal Health Coverage...
2018: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/29456779/shared-decision-making-for-nursing-practice-an-integrative-review
#11
REVIEW
Marie Truglio-Londrigan, Jason T Slyer
Background: Shared decision-making has received national and international interest by providers, educators, researchers, and policy makers. The literature on shared decision-making is extensive, dealing with the individual components of shared decision-making rather than a comprehensive process. This view of shared decision-making leaves healthcare providers to wonder how to integrate shared decision-making into practice. Objective: To understand shared decision-making as a comprehensive process from the perspective of the patient and provider in all healthcare settings...
2018: Open Nursing Journal
https://www.readbyqxmd.com/read/29456764/integrative-analysis-of-the-epigenetic-basis-of-muscle-invasive-urothelial-carcinoma
#12
Thomas Sanford, Maxwell V Meng, Reema Railkar, Piyush K Agarwal, Sima P Porten
Background: Elucidation of epigenetic alterations in bladder cancer will lead to further understanding of the biology of the disease and hopefully improved therapies. Our aim was to perform an integrative epigenetic analysis of invasive urothelial carcinoma of the bladder to identify the epigenetic abnormalities involved in the development and progression of this cancer. Methods: Pre-processed methylation data and RNA-seq data were downloaded from The Cancer Genome Atlas (TCGA) and processed using the R package TCGA-Assembler...
2018: Clinical Epigenetics
https://www.readbyqxmd.com/read/29456281/foster-home-integration-as-a-temporal-indicator-of-relational-well-being
#13
Jeffrey Waid, Brianne H Kothari, Bowen M McBeath, Lew Bank
This study sought to identify factors that contribute to the relational well-being of youth in substitute care. Using data from the [BLIND] study, youth responded to a 9-item measure of positive home integration, a scale designed to assess the relational experiences of youth to their caregivers and their integration into the foster home. Data were collected from youth in six month intervals, for an 18-month period of time. Latent growth curve modeling procedures were employed to determine if child, family, and case characteristics influenced youth's home integration trajectories...
December 2017: Children and Youth Services Review
https://www.readbyqxmd.com/read/29456256/clustering-the-orion-b-giant-molecular-cloud-based-on-its-molecular-emission
#14
Emeric Bron, Chloé Daudon, Jérôme Pety, François Levrier, Maryvonne Gerin, Pierre Gratier, Jan H Orkisz, Viviana Guzman, Sébastien Bardeau, Javier R Goicoechea, Harvey Liszt, Karin Öberg, Nicolas Peretto, Albrecht Sievers, Pascal Tremblin
Context: Previous attempts at segmenting molecular line maps of molecular clouds have focused on using position-position-velocity data cubes of a single molecular line to separate the spatial components of the cloud. In contrast, wide field spectral imaging over a large spectral bandwidth in the (sub)mm domain now allows one to combine multiple molecular tracers to understand the different physical and chemical phases that constitute giant molecular clouds (GMCs). Aims: We aim at using multiple tracers (sensitive to different physical processes and conditions) to segment a molecular cloud into physically/chemically similar regions (rather than spatially connected components), thus disentangling the different physical/chemical phases present in the cloud...
February 2018: Astronomy and Astrophysics
https://www.readbyqxmd.com/read/29456075/qualitative-analysis-of-a-cultural-dexterity-program-for-surgeons-feasible-impactful-and-necessary
#15
Rhea Udyavar, Douglas S Smink, John T Mullen, Tara S Kent, A Green, Alyssa F Harlow, Manuel Castillo-Angeles, Alexandra B Columbus, Adil H Haider
OBJECTIVES: Ineffective cross-cultural communication contributes to adverse outcomes for minority patients. To address this, the authors developed a novel curriculum for surgical residents built on the principle of cultural dexterity, emphasizing adaptability to clinical and sociocultural circumstances to tailor care to the needs of the individual patient. This study's objective was to evaluate the feasibility, acceptability, and perception of this program upon conclusion of its first year...
February 15, 2018: Journal of Surgical Education
https://www.readbyqxmd.com/read/29456069/arthroscopic-superior-capsular-reconstruction-with-acellular-dermal-allograft-for-the-treatment-of-massive-irreparable-rotator-cuff-tears-short-term-clinical-outcomes-and-the-radiographic-parameter-of-superior-capsular-distance
#16
William T Pennington, Brian A Bartz, Joann M Pauli, Carol E Walker, William Schmidt
PURPOSE: This outcome analysis presents 88 consecutive shoulders presenting with irreparable rotator cuff tears that we treated with arthroscopic superior capsular reconstruction (SCR) using an acellular dermal allograft. We also present the concept of superior capsular distance to quantitatively measure the decreased distance present upon restoration of superior capsular integrity. METHODS: A retrospective review was conducted of patients treated with arthroscopic SCR with a minimum 12-month follow-up...
February 15, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29455678/cryptic-species-and-their-utilization-of-indigenous-and-non-indigenous-intermediate-hosts-in-the-acanthocephalan-polymorphus-minutus-sensu-lato-polymorphidae
#17
Maike Zittel, Daniel Grabner, Andre Wlecklik, Bernd Sures, Florian Leese, Horst Taraschewski, Alexander Martin Weigand
The bird-infecting acanthocephalan Polymorphus minutus has been suggested to comprise different lineages or even cryptic species using different intermediate hosts. To clarify this open question, we investigated Polymorphus cf. minutus cystacanths originating from amphipod intermediate hosts from 27 sites in Germany and France. Parasites and hosts were identified using integrated datasets (COI and/or morphology for hosts and COI + ITS1-5.8S-ITS2 for parasites). Mitochondrial and nuclear data (ITS1) strongly support the existence of three cryptic species in Polymorphus cf...
February 19, 2018: Parasitology
https://www.readbyqxmd.com/read/29455584/hepes-activates-a-mit-tfe-dependent-lysosomal-autophagic-gene-network-in-cultured-cells-a-call-for-caution
#18
Marc J Tol, Martijn J C van der Lienden, Tanit L Gabriel, Jacob J Hagen, Saskia Scheij, Tineke Veenendaal, Judith Klumperman, Wilma E Donker-Koopman, Arthur J Verhoeven, Hermen Overkleeft, Johannes M Aerts, Carmen A Argmann, Marco van Eijk
In recent years, the lysosome has emerged as a highly dynamic, transcriptionally regulated organelle that is integral to nutrient-sensing and metabolic rewiring. This is coordinated by a lysosome-to-nucleus signaling nexus in which MTORC1 controls the subcellular distribution of the microphthalmia-transcription factor E (MiT/TFE) family of "master lysosomal regulators". Yet, despite the importance of the lysosome in cellular metabolism, the impact of traditional in vitro culture media on lysosomal dynamics and/or MiT/TFE localization has not been fully appreciated...
February 17, 2018: Autophagy
https://www.readbyqxmd.com/read/29455566/-he-supported-me-100-mexican-immigrant-fathers-daughters-and-adolescent-sexual-health
#19
Kate Coleman-Minahan, Goleen Samari
OBJECTIVE: First and second generation Mexican-origin adolescents in the U.S. face social and economic disadvantage and sexual health disparities. Although fathers can support child and adolescent development, the literature has portrayed Mexican-origin immigrant fathers as emotionally distant and sexist. This study aims to treat migration as a social determinant of health to examine father-daughter relationships and adolescent sexual health in Mexican-origin immigrant families. METHODS: Integrating qualitative data from life history interviews with 21 Mexican-origin young women in immigrant families with quantitative data on first and second generation Mexican-origin young women in the National Longitudinal Study of Adolescent to Adult Health, this study describes father-daughter relationships, examines the association between father-daughter relationships and daughters' early sexual initiation, and considers the impact of migration on the father-daughter relationship and sexual health among Mexican-origin young women...
February 19, 2018: Ethnicity & Health
https://www.readbyqxmd.com/read/29455467/predicting-reintroduction-outcomes-for-highly-vulnerable-species-that-do-not-currently-coexist-with-their-key-threats
#20
Elizabeth H Parlato, Doug P Armstrong
Predicting reintroduction outcomes before populations are released is inherently challenging. It becomes even more difficult when the species being considered for reintroduction no longer co-exists with the key threats limiting its distribution. However, data from other species facing the same threats can be used to make predictions under these circumstances. We present an integrated Bayesian modelling approach for predicting growth of a reintroduced population at a range of predator densities when no data are available for the species in the presence of that predator...
February 17, 2018: Conservation Biology: the Journal of the Society for Conservation Biology
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