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Pneumococcal vaccine in adults

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https://www.readbyqxmd.com/read/28648390/clinical-and-microbiological-characteristics-of-unusual-manifestations-of-invasive-pneumococcal-disease
#1
Adrian Sousa, Maria Teresa Pérez-Rodríguez, Andrés Nodar, Lucía Martínez-Lamas, Francisco Jose Vasallo, Maximiliano Álvarez-Fernández, Manuel Crespo
INTRODUCTION: Invasive pneumococcal disease (IPD) typically presents as bacterial pneumonia, meningitis or primary bacteraemia. However, Streptococcus pneumoniae can produce infection at any level of the body (endocarditis, arthritis, spontaneous bacterial peritonitis, etc.), which is also known as unusual IPD (uIPD). There are very limited data available about the clinical and microbiological profile of these uncommon manifestations of pneumococcal disease. Our aim was to analyse clinical forms, microbiological profile, epidemiology and prognosis of a cohort of patients with unusual invasive pneumococcal disease (uIPD)...
June 22, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/28623156/trends-in-influenza-and-pneumococcal-vaccination-among-us-nursing-home-residents-2006-2014
#2
Carla L Black, Walter W Williams, Inaki Arbeloa, Natasa Kordic, Lindsay Yang, Tom MaCurdy, Chris Worrall, Jeffrey A Kelman
BACKGROUND: Institutionalized adults are at increased risk of morbidity and mortality from influenza and pneumococcal infection. Influenza and pneumococcal vaccination have been shown to be effective in reducing hospitalization and deaths due to pneumonia and influenza in this population. OBJECTIVE: To assess trends in influenza vaccination coverage among US nursing home residents from the 2005-2006 through 2014-2015 influenza seasons and trends in pneumococcal vaccination coverage from 2006 to 2014 among US nursing home residents, by state and demographic characteristics...
June 13, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28623109/serotype-distribution-of-streptococcus-pneumoniae-isolated-from-adult-respiratory-tract-infections-in-nationwide-japanese-surveillances-from-2006-to-2014
#3
Hisashi Shoji, Masayuki Maeda, Takahiro Takuma, Yoshihito Niki
BACKGROUND AND OBJECTIVE: Reports on the efficacy of pneumococcal conjugate vaccines (PCVs) have been received from many countries. However, in countries where the 7-valent PCV (PCV7) and 13-valent PCV (PCV13) were introduced, overall coverage of the serotypes by the vaccine gradually decreased due to pneumococcal serotype replacement. The aim of this study is to assess the distribution of pneumococcal serotypes and to also provide basic data on adult respiratory infection in Japan. METHODS: We analyzed 1086 Streptococcus pneumoniae strains that had been isolated from respiratory tract infection specimens in adult patients from 2006 to 2014...
June 13, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28602602/pneumococcal-conjugate-vaccine-use-in-adults-addressing-an-unmet-medical-need-for-non-bacteremic-pneumococcal-pneumonia
#4
Heather L Sings
Streptococcus pneumoniae is a frequent cause of community acquired pneumonia (CAP), with the largest burden of disease attributed to non-bacteremic pneumonia. Due to the high persistent burden of disease, pneumococcal pneumonia, particularly non-bacteremic pneumococcal pneumonia, continues to be a major public health concern. There are currently two pneumococcal vaccines approved for use in adults in the United States (US) and other countries worldwide: a 23-valent pneumococcal simple polysaccharide vaccine (PPV23), and a 13-valent pneumococcal conjugate vaccine (PCV13)...
June 8, 2017: Vaccine
https://www.readbyqxmd.com/read/28600368/assessing-the-diagnostic-accuracy-of-pcr-based-detection-of-streptococcus-pneumoniae-from-nasopharyngeal-swabs-collected-for-viral-studies-in-canadian-adults-hospitalised-with-community-acquired-pneumonia-a-serious-outcomes-surveillance-sos-network-of-the-canadian
#5
Hayley D Gillis, Amanda L S Lang, May ElSherif, Irene Martin, Todd F Hatchette, Shelly A McNeil, Jason J LeBlanc
STUDY DESIGN: Detection and serotyping of Streptococcus pneumoniae are important to assess the impact of pneumococcal vaccines. This study describes the diagnostic accuracy of PCR-based detection of S. pneumoniae directly from nasopharyngeal (NP) swabs collected for respiratory virus studies. METHODS: Active surveillance for community-acquired pneumonia (CAP) in hospitalised adults was performed from December 2010 to 2013. Detection of pneumococcal CAP (CAPSpn) was performed by urine antigen detection (UAD), identification of S...
June 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/28596792/a-case-series-evaluating-the-serological-response-of-adult-asthma-patients-to-the-23-valent-pneumococcal-polysaccharide-vaccine
#6
C R Laratta, K Williams, D Vethanayagam, M Ulanova, H Vliagoftis
BACKGROUND: Asthma is an independent risk factor for invasive pneumococcal disease; however, the immune response of adult asthma patients to pneumococcal vaccination is unknown. We explore the serologic response of patients with moderate to severe asthma to the 23-valent pneumococcal polysaccharide vaccine (PPSV23). METHODS: Seventeen moderate to severe adult asthma patients that had not been vaccinated against pneumococcus over the 5 previous years were prospectively recruited from a tertiary care asthma clinic...
2017: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/28590240/epidemiology-of-culture-confirmed-infections-of-streptococcus-pneumoniae-2012-2015-and-nasopharyngeal-carriage-in-children-and-households-in-taiwan-2014-2015
#7
Rajendra Prasad Janapatla, Lin-Hui Su, Hsin-Hang Chen, Hsin-Ju Chang, Tian-Chi Tsai, Po-Yen Chen, Chyi-Liang Chen, Cheng-Hsun Chiu
PURPOSE: An observational study was performed to investigate the carriage rate and serotypes of Streptococcus pneumoniae in the 13-valent pneumococcal conjugate vaccine (PCV13) era in Taiwan. METHODOLOGY: From March 2014 to March 2015 a total of 500 healthy children and their households (631 adults) were enrolled from two large medical centres for nasopharyngeal carriage survey. Clinical isolates were prospectively collected from June 2012 to May 2015 at Chang Gung Memorial Hospital...
June 5, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28554501/burden-of-vaccine-preventable-pneumococcal-disease-in-hospitalized-adults-a-canadian-immunization-research-network-cirn-serious-outcomes-surveillance-sos-network-study
#8
Jason J LeBlanc, May ElSherif, Lingyun Ye, Donna MacKinnon-Cameron, Li Li, Ardith Ambrose, Todd F Hatchette, Amanda L Lang, Hayley Gillis, Irene Martin, Melissa K Andrew, Guy Boivin, William Bowie, Karen Green, Jennie Johnstone, Mark Loeb, Anne McCarthy, Allison McGeer, Sanela Moraca, Makeda Semret, Grant Stiver, Sylvie Trottier, Louis Valiquette, Duncan Webster, Shelly A McNeil
BACKGROUND: Pneumococcal community acquired pneumonia (CAPSpn) and invasive pneumococcal disease (IPD) cause significant morbidity and mortality worldwide. Although childhood immunization programs have reduced the overall burden of pneumococcal disease, there is insufficient data in Canada to inform immunization policy in immunocompetent adults. This study aimed to describe clinical outcomes of pneumococcal disease in hospitalized Canadian adults, and determine the proportion of cases caused by vaccine-preventable serotypes...
June 22, 2017: Vaccine
https://www.readbyqxmd.com/read/28542347/effectiveness-of-pneumococcal-vaccines-in-preventing-pneumonia-in-adults-a-systematic-review-and-meta-analyses-of-observational-studies
#9
Myint Tin Tin Htar, Anke L Stuurman, Germano Ferreira, Cristiano Alicino, Kaatje Bollaerts, Chiara Paganino, Ralf René Reinert, Heinz-Josef Schmitt, Cecilia Trucchi, Thomas Vestraeten, Filippo Ansaldi
INTRODUCTION: S. pneumoniae can cause a wide spectrum of diseases, including invasive pneumococcal disease and pneumonia. Two types of pneumococcal vaccines are indicated for use in adults: 23-valent pneumococcal polysaccharide vaccines (PPV23) and a 13-valent pneumococcal conjugate vaccine (PCV13). OBJECTIVE: To systematically review the literature assessing pneumococcal vaccine effectiveness (VE) against community-acquired pneumonia (CAP) in adults among the general population, the immunocompromised and subjects with underlying risk factors in real-world settings...
2017: PloS One
https://www.readbyqxmd.com/read/28516842/serotype-distribution-antimicrobial-resistance-and-prevalence-of-pilus-islets-in-pneumococci-following-the-use-of-conjugate-vaccines
#10
Mitsuyo Kawaguchiya, Noriko Urushibara, Meiji Soe Aung, Masaaki Shinagawa, Satoshi Takahashi, Nobumichi Kobayashi
PURPOSE: In Japan, the 7-valent pneumococcal vaccine (PCV7) was introduced in 2010 and, in 2013, the PCV7 was replaced with the 13-valent pneumococcal vaccine (PCV13). This study was conducted to investigate serotypes, antimicrobial resistance and prevalence of pilus islets in pneumococcal isolates from inpatients in a Japanese tertiary hospital. METHODOLOGY: From April 2011 to February 2016, 151 isolates [95 (18 children, 77 adults) and 56 (19 children, 37 adults) in the PCV7 and PCV13 periods, respectively] were collected...
May 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28502330/three-decades-of-follow-up-of-adults-after-recovery-from-invasive-pneumococcal-pneumonia
#11
Oluwadamilare O Ajayi, Nancy B Norton, Todd W Gress, Ronald J Stanek, Maurice A Mufson
BACKGROUND: Streptococcus pneumoniae infection is the most common cause of community-acquired pneumonia in adults. Invasive pneumococcal disease (IPD) carries a high case fatality rate. We investigated the lifespan of adults who recovered from IPD during a 32-year follow-up. MATERIALS AND METHODS: We determined whether adults discharged after an episode of IPD from hospitals affiliated with the Marshall University Joan C. Edwards School of Medicine in Huntington, West Virginia from 1983-2003 were alive on June 30, 2014...
May 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28498857/cost-effectiveness-of-pneumococcal-vaccination-strategies-for-the-elderly-in-korea
#12
Jung Yeon Heo, Yu Bin Seo, Won Suk Choi, Jacob Lee, Ji Yun Noh, Hye Won Jeong, Woo Joo Kim, Min Ja Kim, Hee Young Lee, Joon Young Song
BACKGROUND: Although the 13-valent pneumococcal conjugate vaccine (PCV13) showed good efficacy against pneumococcal disease in the the CAPiTA trial, the 23-valent pneumococcal polysaccharide vaccination (PPSV23) program has been ongoing for older adults aged ≥ 65 years in Korea since May of 2013. This study aimed to evaluate the cost-effectiveness of the current vaccination strategy (a single-dose PPSV23 vaccination) compared to a single-dose PCV13 vaccination and sequential PCV13-PPSV23 vaccinations in the elderly population aged ≥ 65 years...
2017: PloS One
https://www.readbyqxmd.com/read/28494193/long-term-trends-in-invasive-pneumococcal-disease-in-manitoba-canada
#13
Salaheddin M Mahmud, Hasantha Sinnock, Luiz C Mostaço-Guidolin, Gurpreet Pabla, Aleksandra K Wierzbowski, Songul Bozat-Emre
Invasive pneumococcal disease (IPD) remains a significant public health problem in Manitoba, Canada although publically-funded pneumococcal conjugate (PCV7 and PCV13) and polysaccharide (PPV23) vaccination programs exist. We analyzed routine surveillance and administrative health data to examine trends in IPD rates as these vaccines were introduced. Data on all individuals with a laboratory-confirmed diagnosis of IPD between 2001 and 2014 were obtained from the provincial Communicable Diseases Surveillance database and linked with Manitoba's provincial immunization registry and physician and hospital databases...
May 11, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28482004/imputing-direct-and-indirect-vaccine-effectiveness-of-childhood-pneumococcal-conjugate-vaccine-against-invasive-disease-by-surveying-temporal-changes-in-nasopharyngeal-pneumococcal-colonization
#14
Susan A Nzenze, Shabir A Madhi, Tinevimbo Shiri, Keith P Klugman, Linda de Gouveia, David P Moore, Alan S Karstaedt, Stefano Tempia, Marta C Nunes, Anne von Gottberg
The limited capabilities in most low-middle income countries to study the bebfit of pneumococcal conjugate vaccine (PCV) against invasive pneumococcal disease (IPD), calls for alternate strategies to assess this. We used a mathematical model, to predict the direct and indirect effectiveness of PCV by analyzing serotype specific colonization prevalence and IPD incidence prior to and following childhood PCV immunization in South Africa. We analyzed IPD incidence from 2005-2012 and colonization studies undertaken in HIV-uninfected and HIV-infected child-mother dyads from 2007-2009 (pre-PCV era), in 2010 (7-valent PCV era) and 2012 (13-valent PCV era)...
May 6, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28472614/serotype-changes-and-antimicrobial-nonsusceptibility-rates-of-invasive-and-non-invasive-streptococcus-pneumoniae-isolates-after-implementation-of-10-valent-pneumococcal-nontypeable-haemophilus-influenzae-protein-d-conjugate-vaccine-phid-cv-in-bulgaria
#15
Lena Setchanova, Marianna Murdjeva, Iglika Stancheva, Alexandra Alexandrova, Maria Sredkova, Temenuga Stoicheva, Magda Yoneva, Anna Kurchatova, Ivan Mitov
The 10-valent pneumococcal conjugate vaccine (PCV10) has been included in Bulgarian Childhood Immunization Program since 2010. This study aimed to assess serotype distribution and antimicrobial resistance of 198 invasive and non-invasive Streptococcus pneumoniae strains that had been isolated in Bulgaria during 2011-2016 from patients with invasive (IPD) and non-invasive (NIPD) pneumococcal diseases. The most common invasive serotypes were 3 (10.1%), 19F (4.0%), and 7F (3.0%). A significant decrease in the proportion of invasive vaccine types (VTs) from 64...
May 1, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28472027/surveillance-of-vaccination-coverage-among-adult-populations-united-states-2015
#16
Walter W Williams, Peng-Jun Lu, Alissa O'Halloran, David K Kim, Lisa A Grohskopf, Tamara Pilishvili, Tami H Skoff, Noele P Nelson, Rafael Harpaz, Lauri E Markowitz, Alfonso Rodriguez-Lainz, Amy Parker Fiebelkorn
PROBLEM/CONDITION: Overall, the prevalence of illness attributable to vaccine-preventable diseases is greater among adults than among children. Adults are recommended to receive vaccinations based on their age, underlying medical conditions, lifestyle, prior vaccinations, and other considerations. Updated vaccination recommendations from CDC are published annually in the U.S. Adult Immunization Schedule. Despite longstanding recommendations for use of many vaccines, vaccination coverage among U...
May 5, 2017: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/28469431/opportunities-and-challenges-of-adolescent-and-adult-vaccination-administration-within-pharmacies-in-the-united-states
#17
REVIEW
Jessica Y Islam, Joann F Gruber, Alexandre Lockhart, Manju Kunwar, Spencer Wilson, Sara B Smith, Noel T Brewer, Jennifer S Smith
Pharmacies have been endorsed as alternative vaccine delivery sites to improve vaccination rates through increased access to services. Our objective was to identify challenges and facilitators to adolescent and adult vaccination provision in pharmacy settings in the United States. We recruited 40 licensed pharmacists in states with different pharmacy vaccination laws. Eligible pharmacists previously administered or were currently administering human papillomavirus (HPV); tetanus, diphtheria, and pertussis (TDAP); or meningitis (meningococcal conjugate vaccine [MCV4]) vaccines to adolescents aged 9 to 17 years...
2017: Biomedical Informatics Insights
https://www.readbyqxmd.com/read/28464987/utilizing-pharmacy-intervention-in-asplenic-patients-to-improve-vaccination-rates
#18
Lindsey Rihtarchik, Claire V Murphy, Kyle Porter, Lisa Mostafavifar
PURPOSE: Asplenic patients are at increased risk for post-splenectomy infection caused by Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae type B (Hib), and vaccination rates against these organisms remain low. The purpose of this study was to evaluate vaccination rates before and after implementation of a pharmacist-driven electronic vaccination tracking system. METHODS: This retrospective cohort analysis compared adult splenectomy patients before and after implementation of a pharmacist-driven tracking system with a primary outcome of complete initial vaccination...
April 24, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/28464042/immune-activation-and-hiv-specific-t-cell-responses-are-modulated-by-a-cyclooxygenase-2-inhibitor-in-untreated-hiv-infected-individuals-an-exploratory-clinical-trial
#19
Christian Prebensen, Marius Trøseid, Thor Ueland, Anders Dahm, Per Morten Sandset, Ingeborg Aaberge, Kristian Waalen, Anne Ma Dyrhol-Riise, Kjetil Taskén, Dag Kvale
Pathologically elevated immune activation and inflammation contribute to HIV disease progression and immunodeficiency, potentially mediated by elevated levels of prostaglandin E2, which suppress HIV-specific T cell responses. We have previously shown that a high dose of the cyclooxygenase-2 inhibitor celecoxib can reduce HIV-associated immune activation and improve IgG responses to T cell-dependent vaccines. In this follow-up study, we included 56 HIV-infected adults, 28 antiretroviral therapy (ART)-naïve and 28 on ART with undetectable plasma viremia but CD4 counts below 500 cells/μL...
2017: PloS One
https://www.readbyqxmd.com/read/28457673/awareness-among-adults-of-vaccine-preventable-diseases-and-recommended-vaccinations-united-states-2015
#20
Peng-Jun Lu, Alissa O'Halloran, Erin D Kennedy, Walter W Williams, David Kim, Amy Parker Fiebelkorn, Sara Donahue, Carolyn B Bridges
BACKGROUND: Adults are recommended to receive select vaccinations based on their age, underlying medical conditions, lifestyle, and other considerations. Factors associated with awareness of vaccine-preventable diseases and recommended vaccines among adults in the United States have not been explored. METHODS: Data from a 2015 internet panel survey of a nationally representative sample of U.S. adults aged ≥19years were analyzed to assess awareness of selected vaccine-preventable diseases and recommended vaccines for adults...
May 25, 2017: Vaccine
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