keyword
https://read.qxmd.com/read/38458489/on-and-off-label-atypical-antipsychotic-prescription-trends-across-a-nine-year-period-among-adolescents-pre-to-post-covid-19
#1
JOURNAL ARTICLE
Brianna Costales, Natalie E Slama, Robert B Penfold, Joshua R Nugent, Scott R Spalding, Stacy A Sterling, Esti Iturralde
OBJECTIVE: This study examined atypical antipsychotic prescribing by FDA approved-use (on-label) status for adolescents before and during the Covid-19 pandemic. METHODS: Retrospective data were collected from electronic health records (EHRs) of adolescents aged 10-17 years in Kaiser Permanente Northern California. New outpatient atypical antipsychotic prescription orders during 2013-2021 were evaluated. Prescriptions were categorized as on-label if linked in EHRs to autism, psychosis, bipolar disorder, or Tourette's diagnoses; otherwise, they were potentially off-label (herein, off-label)...
March 6, 2024: Academic Pediatrics
https://read.qxmd.com/read/38428239/abnormal-functional-connectivity-of-the-intrinsic-networks-in-adolescent-bipolar-i-versus-bipolar-ii-disorder
#2
JOURNAL ARTICLE
Qian Xiao, Gui Zhang, Yuan Zhong
BACKGROUND: The symptoms of pediatric bipolar disorder (PBD)-I and PBD-II differ, but accurate identification at an early stage is difficult and may prevent effective treatment of this disorder. Therefore, it is urgent to elucidate a biological marker based on objective imaging indicators to help distinguish the two. Therefore, this research aims to compare the functional connectivity between PBD-I patient and PBD-II patient in different brain networks. METHODS: Our study enrolled 31 PBD-I and 23 PBD-II patients from 12 to 17 years of age...
February 23, 2024: Psychiatry Research. Neuroimaging
https://read.qxmd.com/read/38392585/semi-automatic-analysis-of-specific-electroencephalographic-patterns-during-nrem2-sleep-in-a-pediatric-population-after-sars-cov-2-infection
#3
JOURNAL ARTICLE
Paolo Di Bella, Anna Gaia Attardi, Ambra Butera, Arianna Mancini, Nunzia Calabrò, Elisa Giuseppa Lo Re, Giuseppe Trimarchi, Antonio Gennaro Nicotera, Gabriella Di Rosa, Daniela Lo Giudice
The post-COVID-19 condition is defined by the World Health Organization as the persistence of symptoms or development of new symptoms three months after the initial SARS-CoV-2 infection, lasting for at least two months without a clear explanation. Neuropsychiatric disorders associated with this condition include asthenia, memory and concentration problems, and sleep disturbances. Our study aims to investigate sleep patterns following SARS-CoV-2 infection using EEG findings and a sleep quality questionnaire completed by parents (Sleep Disturbance Scale for Children-SDSC)...
January 30, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38377518/pharmacogenetic-factors-influence-escitalopram-pharmacokinetics-and-adverse-events-in-youth-with-a-family-history-of-bipolar-disorder-a-preliminary-study
#4
JOURNAL ARTICLE
Duncan C Honeycutt, Thomas J Blom, Laura B Ramsey, Jeffrey R Strawn, Kaitlyn M Bruns, Jeffrey A Welge, Luis R Patino, Manpreet K Singh, Melissa P DelBello
Introduction: Escitalopram is an effective and generally well-tolerated antidepressant, but children of parents with bipolar disorder (BD) may be at increased risk for adverse events associated with antidepressants, including increased irritability, restlessness, impulsivity, and manic symptoms. This risk may be influenced by polymorphisms in genes encoding cytochrome P450 enzymes ( CYP2C19 or CYP2D6 ), the serotonin transporter ( SLC6A4 ), and the serotonin receptor 2A subtype ( HTR2A ). We explored whether gene-drug interactions influence the emergence of adverse events in depressed and/or anxious youth with a family history of BD...
February 2024: Journal of Child and Adolescent Psychopharmacology
https://read.qxmd.com/read/38366741/temporal-changes-in-pre-existing-health-conditions-five-years-prior-to-pregnancy-in-british-columbia-canada-2000-2019
#5
JOURNAL ARTICLE
Louise Lundborg, K S Joseph, Sarka Lisonkova, Wee-Shian Chan, Qi Wen, Cande V Ananth, Neda Razaz
BACKGROUND: Pre-existing health conditions increase the risk of obstetric complications during pregnancy and birth. However, the prevalence and recent changes in the frequency of pre-existing health conditions in the childbearing population remain unknown. OBJECTIVES: To estimate the temporal changes in the prevalence of pre-existing health conditions among pregnant women in British Columbia, Canada. METHODS: We carried out a population-based cross-sectional study of 825,203 deliveries in BC between 2000 and 2019 and examined 17 categories of physical and psychiatric health conditions recorded within 5 years before childbirth...
February 17, 2024: Paediatric and Perinatal Epidemiology
https://read.qxmd.com/read/38334088/in-memoriam-professor-joseph-biederman-s-contributions-to-child-and-adolescent-psychiatry
#6
JOURNAL ARTICLE
Stephen V Faraone, Jeffrey H Newcorn, Janet Wozniak, Gagan Joshi, Barbara Coffey, Mai Uchida, Timothy Wilens, Craig Surman, Thomas J Spencer
OBJECTIVE: To provide an overview of Joe Biederman's contributions to child and adolescent psychiatry. METHOD: Nine colleagues described his contributions to: psychopharmacology, comorbidity and genetics, pediatric bipolar disorder, autism spectrum disorders, Tourette's and tic disorders, clinical and neuro biomarkers for pediatric mood disorders, executive functioning, and adult ADHD. RESULTS: Joe Biederman left us with many concrete indicators of his contributions to child and adolescent psychiatry...
February 9, 2024: Journal of Attention Disorders
https://read.qxmd.com/read/38301286/neural-markers-of-mania-that-distinguish-inpatient-adolescents-with-bipolar-disorder-from-those-with-other-psychopathology
#7
JOURNAL ARTICLE
Michele A Bertocci, Renata Rozovsky, Maria Wolfe, Halimah Abdul-Waalee, Mariah Chobany, Greeshma Malgireddy, Jonathan A Hart, Alex Skeba, Tyler Brady, Brianna Lepore, Amelia Versace, Henry W Chase, Boris Birmaher, Mary L Phillips, Rasim S Diler
Pediatric bipolar disorder (BD) is difficult to distinguish from other psychiatric disorders, a challenge which can result in delayed or incorrect interventions. Using neuroimaging we aimed to identify neural measures differentiating a rarified sample of inpatient adolescents with BD from other inpatient psychopathology (OP) and healthy adolescents (HC) during a reward task. We hypothesized reduced subcortical and elevated cortical activation in BD relative to other groups, and that these markers will be related to self-reported mania scores...
January 26, 2024: Psychiatry Research
https://read.qxmd.com/read/38300182/a-pathophysiological-approach-for-selecting-medications-to-treat-nociceptive-and-neuropathic-pain-in-servicemembers
#8
JOURNAL ARTICLE
Khan Thi Nguyen, Daniel W Beauchamp, Reginald B O'Hara
INTRODUCTION: The prevalence of chronic pain of service members (SMs) in the U.S. is estimated to be higher (roughly 31-44%) compared to that of civilian population (26%). This higher prevalence is likely due to the high physical demands related combat and training injuries that are not immediately resolved and worsen over time. Mental Health America reports that chronic pain can lead to other mental health conditions such as severe anxiety, depression, bipolar disorder, and post-traumatic stress disorder...
January 31, 2024: Military Medicine
https://read.qxmd.com/read/38255190/evaluation-of-peripheral-blood-concentrations-of-phoenixin-spexin-nesfatin-1-and-kisspeptin-as-potential-biomarkers-of-bipolar-disorder-in-the-pediatric-population
#9
JOURNAL ARTICLE
Lena Cichoń, Artur Pałasz, Krzysztof M Wilczyński, Aleksandra Suszka-Świtek, Anna Żmijowska, Ireneusz Jelonek, Małgorzata Janas-Kozik
There are some initial suggestions in the literature that phoenixin, spexin, nesfatin-1 and kisspeptin may play a role in the pathogenesis of affective disorders. Therefore, they may also be cautiously considered as potential diagnostic or predictive biomarkers of BD. This study aimed to evaluate the levels of the aforementioned neuropeptides in the peripheral blood of children and adolescents with bipolar. This study included 122 individuals: 67 persons with diagnosed bipolar disorder types I and II constituted the study group, and 55 healthy persons were included in the control group...
December 29, 2023: Biomedicines
https://read.qxmd.com/read/38226278/study-on-the-correlation-between-suicidal-ideation-and-abi3bp-gene%C3%A3-dpysl2-gene-methylation-in-pediatric-bipolar-disorder-with-depressive-episode
#10
JOURNAL ARTICLE
Dilinazi Kari, Peierdun Mijiti, Shaohong Zou, Peiwen Zhang
Patients with bipolar disorder have a higher risk of suicide than the general population. This study aimed to explore the correlation between suicide and gene methylation, as screened by genome-wide scanning, in children and adolescents with bipolar disorder. A total of 45 children and adolescents with bipolar disorder were divided into a suicidal ideation group (n = 41), a non-suicidal ideation group (n = 4), a low-risk group (n = 12), and a middle-to-high-risk group (n = 33)...
January 15, 2024: Heliyon
https://read.qxmd.com/read/38221675/granulomas-in-pediatric-liver-biopsies-single-center-experience
#11
JOURNAL ARTICLE
Muhammad Shaheen, Guang-Sheng Lei, Ryan F Relich, Chaowapong Jarasvaraparn, Kyla M Tolliver, Jean P Molleston, Iván A González
BACKGROUND: Granulomas in pediatric liver biopsies (GPLB) are rare with the largest pediatric cohort reported over 25 years ago. METHODS: Single-center retrospective study of GPLB. RESULTS: Seventeen liver biopsies from 16 patients with granulomas were identified (9 boys, 56%) with a median age of 13 years (range: 1-18) for which the most common indication was the presence of a nodule/mass (47%). Significant comorbidities were seen in 13 patients (81%) and included: liver transplant (25%), history of a neoplasm (25%), autoimmune hepatitis (6%), Crohn disease (6%), bipolar disorder (6%), severe combined immunodeficiency (6%), and sickle cell disease (6%)...
January 14, 2024: Pediatric and Developmental Pathology
https://read.qxmd.com/read/38156605/stimulant-treatment-and-potential-adverse-outcomes-in-pediatric-populations-with-bipolar-disorder-a-systematic-review-of-the-literature
#12
JOURNAL ARTICLE
Hannah O'Connor, Chloe Hutt Vater, Maura DiSalvo, Stephen V Faraone, Janet Wozniak
OBJECTIVE: To explore outcomes of stimulant treatment for ADHD in pediatric populations with particular attention to bipolar disorder (BPD). METHOD: We conducted a literature search of PubMed articles published prior to August 25, 2022 that focused on BPD, mania, and psychosis prior to, or as result of, stimulant treatment. We excluded studies: (1) unrelated to stimulants, (2) general stimulant research, (3) articles older than 40 years, (4) study protocols, or (5) case reports...
December 29, 2023: Journal of Attention Disorders
https://read.qxmd.com/read/38109022/a-systematic-review-of-misdiagnosis-of-pediatric-bipolar-disorder-assessments-and-recommendations
#13
REVIEW
Tabeer Afzal, Justin Louis Hipolito, Laura Jin
Bipolar disorders (BP) are a class of psychiatric disorders with a complex symptom presentation. This systematic review aims to summarize literature pertaining to the misdiagnosis of pediatric BP using the DSM-IV and DSM-5 criteria, while emphasizing the negative impact that untreated BP has on life outcomes. This paper also attempts to outline and summarize available recommendations which may aid in improving diagnostic accuracy of pediatric BP. Scholars Portal Journals, PsychINFO, and MEDLINE databases were used to search articles until March 21, 2023...
December 18, 2023: Research on child and adolescent psychopathology
https://read.qxmd.com/read/38094671/avoiding-a-poke-a-case-series-of-intravenous-olanzapine-in-pediatric-patients
#14
JOURNAL ARTICLE
Abdiweli Hassan, Mike Raschka
Although it was originally developed and approved for the treatment of various psychiatric conditions, such as schizophrenia and bipolar I disorder, recent studies have identified the role of olanzapine in the treatment of intensive care unit (ICU)-related delirium and nausea and vomiting. Unfortunately, olanzapine is currently only indicated to be administered via the intramuscular (IM) route or enteral route, limiting the opportunity of its use in certain pediatric patients. IM injections are typically avoided in pediatrics whenever possible, and it is not uncommon for pediatric patients, especially those in an ICU setting, to be restricted to nothing by mouth...
2023: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://read.qxmd.com/read/38073316/pharmacologic-restraint-use-during-mental-health-admissions-to-children-s-hospitals
#15
JOURNAL ARTICLE
Benjamin Masserano, Matt Hall, Ryan Wolf, Andrew Diedrich, Ankita Gupta, Andrew G Yu, Katherine Johnson, Vineeta Mittal
OBJECTIVES: Primary mental health admissions are increasing across US children's hospitals. These patients may experience agitation requiring pharmacologic restraint. This study characterized pharmacologic restraint use in medical inpatient units by primary mental health diagnosis. METHODS: This retrospective, cross-sectional study used the Pediatric Health Information System database. The study included children aged 5 to 17 years admitted with a primary mental health diagnosis between 2016 and 2021...
December 11, 2023: Pediatrics
https://read.qxmd.com/read/38072245/shared-and-distinct-neurobiological-bases-of-bipolar-disorder-and-attention-deficit-hyperactivity-disorder-in-children-and-adolescents-a-comparative-meta-analysis-of-structural-abnormalities
#16
JOURNAL ARTICLE
Yajing Long, Nanfang Pan, Yifan Yu, Shufang Zhang, Kun Qin, Ying Chen, John A Sweeney, Melissa P DelBello, Qiyong Gong
OBJECTIVE: Pediatric bipolar disorder (PBD) and attention-deficit/hyperactivity disorder (ADHD) frequently co-occur and share dysfunctions in affective and cognitive domains. However, the neural substrates underlying their overlapping and dissociable symptomology have not been well-delineated. We aimed to conduct a meta-analysis of whole-brain voxel-based morphometry studies in PBD and ADHD. METHOD: A systematic literature search was performed in PubMed, Web of Science, and Embase...
December 5, 2023: Journal of the American Academy of Child and Adolescent Psychiatry
https://read.qxmd.com/read/38044479/distinct-functional-patterns-in-child-and-adolescent-bipolar-and-unipolar-depression-during-emotional-processing
#17
JOURNAL ARTICLE
Yun Wu, Yuan Zhong, Gui Zhang, Chun Wang, Ning Zhang, Qingrong Chen
Accumulating evidence from functional magnetic resonance imaging studies supported brain dysfunction during emotional processing in bipolar disorder (BD) and major depressive disorder (MDD). However, child and adolescent BD and MDD could display different activation patterns, which have not been fully understood. This study aimed to investigate common and distinct activation patterns of pediatric BD (PBD) and MDD (p-MDD) during emotion processing using meta-analytic approaches. Literature search identified 25 studies, contrasting 252 PBD patients, and 253 healthy controls (HCs) as well as 311 p-MDD patients and 263 HCs...
December 2, 2023: Cerebral Cortex
https://read.qxmd.com/read/38031362/increased-regional-hurst-exponent-reflects-response-inhibition-related-neural-complexity-alterations-in-pediatric-bipolar-disorder-patients-during-an-emotional-go-nogo-task
#18
JOURNAL ARTICLE
Yi-Bing Guo, Qing Jiao, Xiao-Tong Zhang, Qian Xiao, Zhou Wu, Wei-Fang Cao, Dong Cui, Guang-Hui Yu, Ru-Hai Dou, Lin-Yan Su, Guang-Ming Lu
Fractal patterns have been shown to change in resting- and task-state blood oxygen level-dependent signals in bipolar disorder patients. However, fractal characteristics of brain blood oxygen level-dependent signals when responding to external emotional stimuli in pediatric bipolar disorder remain unclear. Blood oxygen level-dependent signals of 20 PBD-I patients and 17 age- and sex-matched healthy controls were extracted while performing an emotional Go-Nogo task. Neural responses relevant to the task and Hurst exponent of the blood oxygen level-dependent signals were assessed...
November 29, 2023: Cerebral Cortex
https://read.qxmd.com/read/37910863/initiation-of-aripiprazole-lauroxil-long-acting-injectable-in-adolescents-during-hospitalization-a-case-series
#19
JOURNAL ARTICLE
Esther Moon, Erika Kim, Andrew Williams
Objective: The efficacy and safety of long-acting injectable (LAI) antipsychotics in the pediatric population is not well established due to limited evidence. This case series aims to describe off-label use of aripiprazole lauroxil (AL) LAI in adolescent inpatients, including findings on safety and readmission trends. Methods: This was a retrospective chart review of patients who were initiated on AL LAI while admitted at a county-based adolescent psychiatric unit between March 2021 and March 2023. Data comprised sociodemographic and clinical characteristics, such as psychiatric diagnoses, prior antipsychotic trials, and history of nonadherence...
December 2023: Journal of Child and Adolescent Psychopharmacology
https://read.qxmd.com/read/37900296/hard-to-treat-or-hard-to-catch-clinical-features-and-therapeutic-outcomes-of-help-seeking-foster-care-youths-with-mood-disorders
#20
JOURNAL ARTICLE
Xavier Benarous, Hélène Lahaye, Hugues Pellerin, Angèle Consoli, David Cohen, Réal Labelle, Johanne Renaud, Priscille Gérardin, Fabienne El-Khoury, Judith van der Waerden, Jean-Marc Guilé
INTRODUCTION: The high level of emotional problems in youths placed in foster care contrasts with the limited use of evidence-based treatments. This study aims to better characterize the clinical features and therapeutic outcomes of foster care youths with mood disorders. METHODS: A secondary analysis of data collected in the context of a French-Canadian clinical research network on pediatric mood disorders in four sites was conducted to compare three groups of patients with depressive or bipolar disorder: those without exposure to child welfare intervention (WCWI, n  = 181), those who received non-placement psychosocial intervention (NPI, n  = 62), and those in placement interventions (PI, n  = 41)...
2023: Frontiers in Psychiatry
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