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Colon and rectal cancers

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https://www.readbyqxmd.com/read/29142905/p-cadherin-cdh3-is-overexpressed-in-colorectal-tumors-and-has-potential-as-a-serum-marker-for-colorectal-cancer-monitoring
#1
H M C Shantha Kumara, Geoffrey A Bellini, Otavia L Caballero, Sonali A C Herath, Tao Su, Aqeel Ahmed, Linda Njoh, Vesna Cekic, Richard L Whelan
Introduction: Placental-Cadherin (CDH3) is a cell adhesion molecule vital to cellular localization and tissue integrity. It is highly expressed in the placenta (PLC)and is overexpressed by many types of cancer. P-cadherin levels in colorectal cancer (CRC) remains poorly characterized. This study's purpose was to determine P-cadherin expression in CRC and normal tissues and to assess plasma CDH3 levels in order to determine the relationship, if any, between cancer stage, P-cadherin expression and plasma CDH3 levels...
September 2017: Oncoscience
https://www.readbyqxmd.com/read/29137344/red-and-processed-meat-consumption-and-colorectal-cancer-risk-a-systematic-review-and-meta-analysis
#2
Zhanwei Zhao, Quanxin Feng, Zifang Yin, Jianbo Shuang, Bin Bai, Pengfei Yu, Min Guo, Qingchuan Zhao
The associations between red and processed meat consumption and the risk of colorectal cancer types have not been conclusively defined. We performed a systematic review and meta-analysis to analyze these associations. We searched PubMed and EMBASE to identify studies published from inception through September 2016. Dose-response, subgroup and subtype analyses of colorectal cancer (colon cancer, proximal colon cancer, distal colon cancer and rectal cancer) were performed. We ultimately selected 60 eligible studies...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29134384/totally-robotic-single-docking-low-anterior-resection-for-rectal-cancer-pearls-and-pitfalls
#3
J W T Toh, A Zakaria, I Yang, S H Kim
Total robotic resection of mid- and low rectal cancers confers technical advantages within the confines of the pelvis and allows difficult rectal cancer cases to be performed efficiently with less risk of conversion to open. To maximize the advantage of robotic surgery, we utilize the technique of single docking totally robotic dissection for rectal cancer for both the Da Vinci Si and Xi Surgical Systems. All steps are performed robotically, with the surgery divided into two phases. The first phase consists of inferior mesenteric artery and vein ligation, sigmoid and descending colon mobilization and splenic flexure takedown...
November 13, 2017: Techniques in Coloproctology
https://www.readbyqxmd.com/read/29130230/-protective-measures-in-laparoscopic-resection-for-upper-or-mid-rectal-cancer-and-sigmoid-colon-cancer-with-transrectal-specimen-extraction-surgery
#4
Chuangang Fu, Zhuqing Zhou, Junyi Han, Bin Lu, Wei Gao, Zhe Zhu, Qixin Jiang, Fang Ji, Tao Du
OBJECTIVE: To introduce the use of a self-made specimen protective sleeve in laparoscopic resection for upper or mid rectal cancer and sigmoid colon cancer with transrectal specimen extraction surgery and the improvement of implantation method, so as to avoid and reduce bacterial contamination and tumor cell dissemination in abdominal cavity. METHODS: During June 2015 and May 2017, 48 cases of high located rectal or sigmoid colon cancer were operated laparoscopically with natural orifices specimen extraction surgery (NOSES) using a self-made specimen protecting sleeve...
October 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29128266/molecular-profiling-of-patients-with-advanced-colorectal-cancer-princess-margaret-cancer-centre-experience
#5
Joanne W Chiu, Monika K Krzyzanowska, Stefano Serra, Jennifer J Knox, Neesha C Dhani, Helen Mackay, David Hedley, Malcolm Moore, Geoffrey Liu, Ronald L Burkes, Christine Brezden-Masley, Michael H Roehrl, Kenneth J Craddock, Ming-Sound Tsao, Tong Zhang, Celeste Yu, Suzanne Kamel-Reid, Lillian L Siu, Philippe L Bedard, Eric X Chen
BACKGROUND: Molecular aberrations in KRAS, NRAS, BRAF, and PIK3CA have been well-described in advanced colorectal cancer. The incidences of other mutations are less known. We report results of molecular profiling of advanced colorectal cancer in an academic cancer center. PATIENTS AND METHODS: Patients with advanced colorectal were enrolled in an institution-wide molecular profiling program. Profiling was performed on formalin-fixed paraffin embedded archival tissues using a customized MassArray panel (23 genes, 279 mutations) or the Illumina MiSeq TruSeq Cancer Panel (48 genes, 212 amplicons, ≥ 500× coverage) in a Clinical Laboratory Improvement Amendments-certified laboratory...
October 23, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/29124480/a-case-of-napsin-a-positive-metastatic-lung-cancer-originating-from-the-colon
#6
Tomokazu Ito, Kozo Nakanishi, Hidenori Goto
BACKGROUND: We report a case of napsin A-positive metastatic lung cancer originating from the colon. No cases of napsin A-positive metastatic lung tumors originating from colorectal cancer have been reported previously. CASE PRESENTATION: Computed tomography identified a small lung nodule in a 70-year-old male patient, 18 months after resection for rectal cancer. The size of the lung tumor increased from 1.8 to 2.1 cm in 6 months and metastasis from the rectal cancer was suspected...
November 9, 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/29109391/occult-spigelian-hernia-presenting-as-inability-to-complete-colon-cancer-screening-in-a-patient-with-a-history-of-rectal-cancer
#7
Daniel Persinger, Marc D Basson
BACKGROUND While it is well known that abdominal wall hernias can pose obstacles for colonoscopy, these may not be obvious in obese patients, particularly when the hernia is in an unusual place. CASE REPORT A 62-year-old man presented with inability to complete colon cancer screening by means of colonoscopy or barium enema. On exam, he was noted to have a Spigelian hernia present in his left lower quadrant abdominal wall. CT colonography identified incarcerated sigmoid colon within the hernia accounting for his inability to complete colonoscopy or barium enema...
November 7, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29101300/pharmacoproteomic-characterisation-of-human-colon-and-rectal-cancer
#8
Martin Frejno, Riccardo Zenezini Chiozzi, Mathias Wilhelm, Heiner Koch, Runsheng Zheng, Susan Klaeger, Benjamin Ruprecht, Chen Meng, Karl Kramer, Anna Jarzab, Stephanie Heinzlmeir, Elaine Johnstone, Enric Domingo, David Kerr, Moritz Jesinghaus, Julia Slotta-Huspenina, Wilko Weichert, Stefan Knapp, Stephan M Feller, Bernhard Kuster
Most molecular cancer therapies act on protein targets but data on the proteome status of patients and cellular models for proteome-guided pre-clinical drug sensitivity studies are only beginning to emerge. Here, we profiled the proteomes of 65 colorectal cancer (CRC) cell lines to a depth of > 10,000 proteins using mass spectrometry. Integration with proteomes of 90 CRC patients and matched transcriptomics data defined integrated CRC subtypes, highlighting cell lines representative of each tumour subtype...
November 3, 2017: Molecular Systems Biology
https://www.readbyqxmd.com/read/29097072/recommendations-for-randomised-trials-in-surgical-oncology
#9
J C Glasbey, E L Magill, K Brock, S P Bach
Trials of surgical procedures in the treatment of malignant disease face a unique set of challenges. This review aimed to describe recommendations for the design, delivery and reporting of randomised trials in surgical oncology. A literature search was carried out without date limits to identify articles related to trial methodology research in surgery and surgical oncology. A narrative review was framed around two open National Institute of Health Research portfolio trials in colon and rectal cancer: the STAR-TREC trial (ISRCTN14240288) and the ROCCS trial (ISRCTN46330337)...
October 30, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29084272/residential-road-traffic-noise-exposure-and-colorectal-cancer-survival-a-danish-cohort-study
#10
Nina Roswall, Pernille Envold Bidstrup, Ole Raaschou-Nielsen, Steen Solvang Jensen, Kim Overvad, Jytte Halkjær, Mette Sørensen
BACKGROUND: Residential traffic noise exposure may entail sleep disruption and compromised circadian functioning; two factors which have been associated with a poor colorectal cancer (CRC) prognosis. Hence, the aim of the present study was to investigate the association between residential road traffic noise and CRC survival. METHODS AND MATERIALS: Road traffic noise was calculated for all residential addresses from 1987 to February 2012 for incident CRC cases (n = 1,234) in a cohort of 57,053 Danes...
2017: PloS One
https://www.readbyqxmd.com/read/29082697/-effect-of-resveratrol-in-regulating-proliferation-and-apoptosis-of-rectal-cancer-cells-via-up-regulating-pten
#11
Ling-Juan Lao, Xin-Jiang Song, Jia Xu
To analysis the relative expression of PTEN(phosphatase and tensin homology deleted on chromosome ten) in rectal cancer cell lines and the effects of resveratrol on cell proliferation and apoptosis of rectal cancer cells in vitro. Western blot was used to assess the protein expression of PTEN in rectal cancer cell lines and non-malignant colon epithelial cell line. After treating human rectal cancer cell line SW480 with different concentrations of resveratrol, the cellular proliferation was detected by cell counting Kit-8(CCK-8) assay...
May 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29076478/-urgent-surgical-care-for-patients-with-colon-cancer-complicated-by-hemorrhage
#12
A V Shabunin, Z A Bagateliya, I Yu Korzheva, S S Lebedev
AIM: Comparative evaluation of the effectiveness of various hemostatic methods in patients with colon and rectal cancer complicated by bleeding. MATERIAL AND METHODS: We examined 77 hospitalized patients with colon and rectal cancer complicated by bleeding. Conservative therapy was effective in 11 patients (group I), endoscopic hemostasis in 49 cases (group II), 17 patients underwent emergency surgery (bowel resection/ internal iliac arteries ligation) (group III)...
2017: Khirurgiia
https://www.readbyqxmd.com/read/29076310/diffuse-reflectance-spectroscopy-as-a-tool-for-real-time-tissue-assessment-during-colorectal-cancer-surgery
#13
Elisabeth J M Baltussen, Petur Snaebjornsson, Susan G Brouwer de Koning, Henricus J C M Sterenborg, Arend G J Aalbers, Niels Kok, Geerard L Beets, Benno H W Hendriks, Koert F D Kuhlmann, Theo J M Ruers
Colorectal surgery is the standard treatment for patients with colorectal cancer. To overcome two of the main challenges, the circumferential resection margin and postoperative complications, real-time tissue assessment could be of great benefit during surgery. In this ex vivo study, diffuse reflectance spectroscopy (DRS) was used to differentiate tumor tissue from healthy surrounding tissues in patients with colorectal neoplasia. DRS spectra were obtained from tumor tissue, healthy colon, or rectal wall and fat tissue, for every patient...
October 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29067939/a-case-of-total-laparoscopic-sigmoidectomy-involving-the-use-of-needle-forceps-and-transanal-specimen-extraction-for-sigmoid-colon-cancer
#14
Rina Takahashi, Kazuhiro Sakamoto, Hisashi Ro, Kazumasa Kure, Masaya Kawai, Shun Ishiyama, Kiichi Sugimoto, Yutaka Kojima, Atsushi Okuzawa, Yuichi Tomiki
A 76-year-old male underwent endoscopic mucosal resection for a stage T1 tumour of the sigmoid colon. We performed laparoscopic sigmoidectomy through 5 ports using needlescopic instruments. The resected specimen was extracted from the abdominal cavity transanally. After attaching an anvil to the sigmoidal stump, the rectal stump was reclosed using an endoscopic linear stapler, and then, colorectal anastomosis was conducted using the double stapling technique. Performing transanal specimen extraction using needlescopic forceps improves aesthetic outcomes and reduces post-operative pain and the risk of abdominal incisional hernias...
October 23, 2017: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/29066910/cyp19a1-gene-polymorphism-and-colorectal-cancer-etiology-in-saudi-population-case-control-study
#15
Fatimah Basil Al-Mukaynizi, Mohammed Alanazi, Sooad Al-Daihan, Narasimha Reddy Parine, Majid Almadi, Abdulrahman Aljebreen, Nahla Azzam, Othman Alharbi, Maha Arafah, Arjumand Warsy
BACKGROUND: Considerable interest is directed toward the enzyme aromatase (CYP19A1) and the development of cancer, due to CYP19A1's role in estrogen biosynthesis. Several cancers display excessive intra-tumor accumulation of estrogens, and aromatase inhibitors are used for treatment. The CYP19A1 gene exhibits polymorphism and mutations that can alter its expression or aromatase activity and influence estrogen production. We designed this study to investigate the link between CYP19A1 polymorphism and susceptibility to colorectal cancer (CRC) development in Saudis...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29066690/-preoperative-prognostic-nutrition-index-is-a-predictive-factor-of-complications-in-laparoscopic-colorectal-surgery
#16
Yuki Yano, Masano Sagawa, Hajime Yokomizo, Sachiyo Okayama, Yasufumi Yamada, Takebumi Usui, Kentaro Yamaguchi, Shunichi Shiozawa, Kazuhiko Yoshimatsu, Takeshi Shimakawa, Takao Katsube, Hiroyuki Kato, Yoshihiko Naritaka
Paitients and methods: We retrospectively reviewed a database of 188 patients who underwent resection for colorectal cancer with laparoscopic surgery between July 2007 and March 2015. The prognostic nutrition index(PNI), modified Glas- gow prognostic score(mGPS), controlling nutritional status(CONUT), and neutrophil/lymphocyte ratio(N/L)were measured in these patients. We examined the association between postoperative complications and clinicopathological factors. RESULTS: The study included 110 men and 78 women...
October 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29058595/world-wide-immunoscore-task-force-meeting-report-from-the-melanoma-bridge-napoli-november-30th-december-3rd-2016
#17
Jerome Galon, Alessandro Lugli, Carlo Bifulco, Franck Pages, Giuseppe Masucci, Francesco M Marincola, Paolo A Ascierto
The predictive accuracy of the traditional staging system is based on disease progression as a tumour cell-autonomous process, but it fails to incorporate the effects of the host immune response. A precise analysis of the immune component of the tumour microenvironment by computer-based analysis may be essential to managing patients better, opening the road to an expertise in this new emerging field. The Immunoscore as a new possible approach in the classification of cancer, designated TNM-Immune, studied in colon cancer patients with predictive and prognostic value...
October 20, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29055095/the-joint-effects-of-major-lifestyle-factors-on-colorectal-cancer-risk-among-chinese-men-a-prospective-cohort-study
#18
Qing-Li Zhang, Long-Gang Zhao, Hong-Lan Li, Jing Gao, Gong Yang, Jing Wang, Wei Zheng, Xiao-Ou Shu, Yong-Bing Xiang
Previous studies have suggested individual healthy lifestyle factors are related to lower risk of colorectal cancer. Their joint effects, however, have rarely been investigated. We aimed to assess the combined lifestyle impact on colorectal cancer risk and to estimate the population attributable risks of these lifestyle factors. Using data from the Shanghai Men's Health Study (2002-2013), we constructed healthy lifestyle index composing the following lifestyle factors: smoking, alcohol consumption, diet, waist-hip ratio and exercise participation...
October 21, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29054345/the-effect-of-formal-robotic-residency-training-on-the-adoption-of-minimally-invasive-surgery-by-young-colorectal-surgeons
#19
David E Disbrow, Stephanie M Pannell, Beth-Ann Shanker, Jeremy Albright, Juan Wu, Amir Bastawrous, Mark Soliman, Jane Ferraro, Robert K Cleary
OBJECTIVE: The minimally invasive approach to colorectal surgery is still underused. Only 50% to 60% of colectomies and 10% to 20% of rectal resections for cancer are performed laparoscopically. The increasing adoption of the robotic platform for colorectal surgery warrants re-evaluation of minimally invasive surgery (MIS) training techniques. Although considering lessons learned from past laparoscopic training, a standardized national robotic training program for colon and rectal surgery residents was developed and implemented in 2011...
October 17, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/29049477/association-of-the-addition-of-oral-antibiotics-to-mechanical-bowel-preparation-for-left-colon-and-rectal-cancer-resections-with-reduction-of-surgical-site-infections
#20
Elaine Vo, Nader N Massarweh, Christy Y Chai, Hop S Tran Cao, Nader Zamani, Sherry Abraham, Kafayat Adigun, Samir S Awad
Importance: Surgical site infections (SSIs) after colorectal surgery remain a significant complication, particularly for patients with cancer, because they can delay the administration of adjuvant therapy. A combination of oral antibiotics and mechanical bowel preparation (MBP) is a potential, yet controversial, SSI prevention strategy. Objective: To determine the association of the addition of oral antibiotics to MBP with preventing SSIs in left colon and rectal cancer resections and its association with the timely administration of adjuvant therapy...
October 18, 2017: JAMA Surgery
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