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https://www.readbyqxmd.com/read/28856541/glycoprotein-nmb-an-emerging-role-in-neurodegenerative-disease
#1
REVIEW
Kevin M Budge, Matthew L Neal, Jason R Richardson, Fayez F Safadi
Neurodegeneration is characterized by severe neuronal loss leading to the cognitive and physical impairments that define various neurodegenerative diseases. Neuroinflammation is one hallmark of neurodegenerative diseases and can ultimately contribute to disease progression. Increased inflammatory cytokines, such as interleukin-6 (IL-6), interleukin-1β (IL-1 β), and tumor necrosis factor-α (TNF-α) are associated with Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS)...
August 30, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28832808/prolonged-survival-after-surgical-resection-of-cerebral-metastasis-from-melanoma-with-multisystemic-metastasis-already-present-a-case-report-and-literature-review
#2
Samer Saad Hoz, Ahmed Aman Alkhaleeli, Awfa Aktham
CONTEXT: Malignant melanoma is the third most common cause of cerebral metastases after breast and lung cancer. Despite advances in therapeutic options, the prognosis for patients with cerebral metastases from melanoma remains poor, with a median survival time of six months after diagnosis. CASE REPORT: A 65-year-old woman was diagnosed with a malignant melanoma on the third toe of her left foot.The tumorous spot was excised surgically. However, the melanoma reappeared after one year and skin biopsy confirmed recurrence of malignant melanoma...
August 21, 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/28724319/cerebral-hemorrhage-as-the-initial-manifestation-in-patients-with-systemic-cancer
#3
Gelun Huang, Li Chen, Chao Qin, Daobin Cheng, Qiuhong Lu, Lixia Yu, Zhijian Liang
BACKGROUND: Cerebral hemorrhage as well as ischemic stroke is one of the common complications among patients with cancer. Ischemic stroke could be the initial manifestation in some patients with cancer. Meanwhile, some patients with cancer also could present cerebral hemorrhage as the initial manifestation, and further studies are required to determine whether these patients have their unique clinical features. AIM: To investigate the clinical features and underlying pathogenesis of concealed systemic cancer patients with cerebral hemorrhage as the initial manifestation...
August 1, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28283736/phase-1b-study-of-pembrolizumab-mk-3475-anti-pd-1-monoclonal-antibody-in-japanese-patients-with-advanced-melanoma-keynote-041
#4
MULTICENTER STUDY
Naoya Yamazaki, Tatsuya Takenouchi, Manabu Fujimoto, Hironobu Ihn, Hiroshi Uchi, Takashi Inozume, Yoshio Kiyohara, Hisashi Uhara, Kazuhiko Nakagawa, Hiroshi Furukawa, Hidefumi Wada, Kazuo Noguchi, Takashi Shimamoto, Kenji Yokota
PURPOSE: This phase I b study evaluated the safety and anti-tumor activity of pembrolizumab in Japanese patients with advanced melanoma. METHODS: Pembrolizumab (2 mg/kg) was given every 3 weeks (Q3W) for up to 2 years or until confirmed progression or unacceptable toxicity. The tumor response was assessed as per the Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST v1.1) by both investigator review and central review. RESULTS: Forty-two patients with advanced melanoma received pembrolizumab...
April 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28216727/high-altitude-dermatology
#5
Lt Col G K Singh
Approximately, 140 million people worldwide live permanently at high altitudes (HAs) and approximately another 40 million people travel to HA area (HAA) every year for reasons of occupation, sports or recreation. In India, whole of Ladakh region, part of Northwest Kashmir, Northern part of Sikkim and Tenga valley of Arunachal are considered inhabited areas of HAA. The low quantity of oxygen, high exposure of ultraviolet (UV) light, very low humidity, extreme subzero temperature in winter, high wind velocity, make this region difficult for lowlanders as well as for tourists...
January 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28121927/primary-cerebral-malignant-melanoma-a-case-report-with-literature-review
#6
REVIEW
Kai Tang, Xiangyi Kong, Gengsheng Mao, Ming Qiu, Haibo Zhu, Lei Zhou, Qingbin Nie, Yi Xu, Shiwei Du
Primary intracranial melanomas are uncommon and constitute approximately 1% of all melanoma cases and 0.07% of all brain tumors. In nature, these primary melanomas are very aggressive and can spread to other organs.We report an uncommon case of primary cerebral malignant melanoma-a challenging diagnosis guided by clinical presentations, radiological features, and surgical biopsy results, aiming to emphasize the importance of considering primary melanoma when making differential diagnoses of intracranial lesions...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28045814/recalcitrant-invasive-skin-cancer-of-the-scalp-combined-extirpation-and-microsurgical-reconstruction-without-cranioplasty
#7
Gerald J Cho, Frederick Wang, Steven M Garcia, Jennifer Viner, William Y Hoffman, Michael W McDermott, Jason H Pomerantz
BACKGROUND: Recurrent invasive skin cancer of the scalp and calvarium is a difficult problem for which universally accepted treatment protocols have not been established. The authors present their 10-year experience with treatment of this specific subset of scalp reconstruction patients and present a successful treatment algorithm that is well suited to this patient population. METHODS: The authors retrospectively reviewed all patients of microsurgical scalp reconstruction performed from 2005 to 2015 that involved invasive cutaneous malignancies of the scalp and calvarium...
March 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28012127/fluorescein-sodium-guided-resection-of-cerebral-metastases-an-update
#8
Julius Höhne, Christoph Hohenberger, Martin Proescholdt, Markus J Riemenschneider, Christina Wendl, Alexander Brawanski, Karl-Michael Schebesch
BACKGROUND: Cerebral metastasis (CM) is the most common malignancy affecting the brain. In patients eligible for surgery, complete tumor removal is the most important predictor of overall survival and neurological outcome. The emergence of surgical microscopes fitted with a fluorescein-specific filter have facilitated fluorescein-guided microsurgery and identification of tumor tissue. In 2012, we started evaluating fluorescein (FL) with the dedicated microscope filter in cerebral metastases (CM)...
February 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28011499/development-of-a-survival-score-for-patients-with-cerebral-metastases-from-melanoma
#9
Lena Sehmisch, Steven E Schild, Dirk Rades
BACKGROUND/AIM: To develop a survival score for patients receiving whole-brain irradiation (WBI) alone for cerebral metastases from melanoma. PATIENTS AND METHODS: Forty-five patients who met the required criteria were included. WBI doses had to be >30 Gy. Six variables were analyzed: age, gender, Karnofsky performance score (KPS), number of cerebral metastases, extracranial metastatic spread and interval from diagnosis of melanoma until WBI. In order to estimate patients' survival scores, variables showing at least a trend (p<0...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28008676/direct-mapping-of-melanoma-cell-endothelial-cell-interactions
#10
Béla Varga, Csilla Fazakas, Judit Molnár, Imola Wilhelm, Réka A Domokos, István A Krizbai, Zsolt Szegletes, György Váró, Attila G Végh
The most life-threatening aspect of cancer is metastasis; cancer patient mortality is mainly due to metastasis. Among all metastases, presence of brain metastasis is one with the poorest prognosis; the median survival time can be counted in months. Therefore, prevention or decreasing their incidence would be highly desired both by patients and physicians. Metastatic cells invading the brain must breach the cerebral vasculature, primarily the blood-brain barrier. The key step in this process is the establishment of firm adhesion between the cancer cell and the cerebral endothelial layer...
June 2017: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/27924154/early-diagnosis-of-brain-metastases-using-a-biofluids-metabolomics-approach-in-mice
#11
James R Larkin, Alex M Dickens, Timothy D W Claridge, Claire Bristow, Kleopatra Andreou, Daniel C Anthony, Nicola R Sibson
Over 20% of cancer patients will develop brain metastases. Prognosis is currently extremely poor, largely owing to late-stage diagnosis. We hypothesized that biofluid metabolomics could detect tumours at the micrometastatic stage, prior to the current clinical gold-standard of blood-brain barrier breakdown. Metastatic mammary carcinoma cells (4T1-GFP) were injected into BALB/c mice via intracerebral, intracardiac or intravenous routes to induce differing cerebral and systemic tumour burdens. B16F10 melanoma and MDA231BR-GFP human breast carcinoma cells were used for additional modelling...
2016: Theranostics
https://www.readbyqxmd.com/read/27915116/7t-mr-of-intracranial-pathology-preliminary-observations-and-comparisons-to-3t-and-1-5t
#12
Emmanuel C Obusez, Mark Lowe, Se-Hong Oh, Irene Wang, Jennifer Bullen, Paul Ruggieri, Virginia Hill, Daniel Lockwood, Todd Emch, Doksu Moon, Gareth Loy, Jonathan Lee, Matthew Kiczek, Manoj Massand, Volodymyr Statsevych, Todd Stultz, Stephen E Jones
PURPOSE: There have been an increasing number of studies involving ultra-high-field 7T of intracranial pathology, however, comprehensive clinical studies of neuropathology at 7T still remain limited. 7T has the advantage of a higher signal-to-noise ratio and a higher contrast-to-noise ratio, compared to current low field clinical MR scanners. We hypothesized 7T applied clinically, may improve detection and characterization of intracranial pathology. MATERIALS AND METHODS: We performed an IRB-approved 7T prospective study of patients with neurological disease who previously had lower field 3T and 1...
November 30, 2016: NeuroImage
https://www.readbyqxmd.com/read/27878363/improvement-of-overall-survival-in-stage-iv-melanoma-patients-during-2011-2014-analysis-of-real-world-data-in-441-patients-of-the-german-central-malignant-melanoma-registry-cmmr
#13
Andrea Forschner, Felizitas Eichner, Teresa Amaral, Ulrike Keim, Claus Garbe, Thomas Kurt Eigentler
BACKGROUND: During 2011 and 2014, new treatment modalities like tyrosine kinase inhibitors and checkpoint inhibitors were introduced into the therapy of metastatic melanoma. This study addresses the question whether overall survival (OS) of metastatic melanoma patients has already been improved in 441 patients diagnosed with metastatic melanoma between 2011 and 2014 in the real-world setting at the University Hospital Tuebingen. METHODS: All patients were documented with their different therapies by the CMMR and followed up until March 2016...
March 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27822695/the-treatment-of-melanoma-brain-metastases
#14
REVIEW
Nour Kibbi, Harriet Kluger
Melanoma is the malignancy with the highest rate of dissemination to the central nervous system once it metastasizes. Until recently, the prognosis of patients with melanoma brain metastases (MBM) was poor. In recent years, however, the prognosis has improved due to high-resolution imaging that facilitates early detection of small asymptomatic brain metastases and early intervention with local modalities such as stereotactic radiosurgery. More recently, a number of systemic therapies have been approved by the Food and Drug Administration for metastatic melanoma, resulting in improved survival for many MBM patients...
December 2016: Current Oncology Reports
https://www.readbyqxmd.com/read/27759578/tumor-free-osteosclerotic-lesions-in-patients-treated-for-metastatic-melanoma-using-braf-inhibitors
#15
Lea Bottlaender, Marie Perier-Muzet, Véronique Lapras, Luc Thomas, Stephane Dalle
BRAF inhibitors (vemurafenib and dabrafenib) are commonly prescribed in BRAF-mutant metastatic melanoma and allow improvement of the overall survival and progression-free survival. They are, however, accompanied by many adverse effects which mainly affect the skin. We observed on computed tomographic scans in three different patients after 3 months of treatment, the onset of osteosclerotic lesions. In parallel, the computed tomographic scans showed a significant reduction in all of the previously identified metastases in all patients...
February 2017: Melanoma Research
https://www.readbyqxmd.com/read/27757312/activity-and-safety-of-radiotherapy-with-anti-pd-1-drug-therapy-in-patients-with-metastatic-melanoma
#16
E Liniker, A M Menzies, B Y Kong, A Cooper, S Ramanujam, S Lo, R F Kefford, G B Fogarty, A Guminski, T W Wang, M S Carlino, A Hong, G V Long
The anti-PD-1 antibodies nivolumab and pembrolizumab are active in metastatic melanoma; however, there is limited data on combining anti-PD-1 antibody and radiotherapy (RT). We sought to review clinical outcomes of patients receiving RT and anti-PD-1 therapy. All patients receiving anti-PD-1 antibody and RT for metastatic melanoma were identified. RT and systemic treatment, clinical outcome, and toxicity data were collected. Fifty-three patients were included; 35 patients received extracranial RT and/or intracranial stereotactic radiosurgery (SRS) and 21 received whole brain radiotherapy (WBRT) (three of whom also received SRS/extracranial RT)...
2016: Oncoimmunology
https://www.readbyqxmd.com/read/27667577/brain-metastases-surgical-treatment-and-overall-survival
#17
Giancarlo D'Andrea, Lucia Palombi, Giuseppe Minniti, Alessandro Pesce, Paolo Marchetti
BACKGROUND: Brain metastases occur in 10%-40% of patients with cancer and are more common than primary brain tumors (30%-40%); their incidence is growing because of improvements in control of systemic disease, better radiologic detection, and prolonged survival. Modern treatment of brain metastases has dramatically changed the expected prognosis. Traditionally, the prognosis has been considered very poor, and patients were referred to palliative treatment because of their terminal stage; however, new prognostic indexes have been proposed to evaluate these patients...
January 2017: World Neurosurgery
https://www.readbyqxmd.com/read/27630330/a-case-of-vanishing-brain-metastasis-in-a-melanoma-patient-on-nivolumab
#18
Alina Basnet, Nibal Saad, Sam Benjamin
BACKGROUND: Melanoma is among the top three cancers to present with brain metastasis. The risk of brain metastases in advanced melanoma increases with disease duration. Cytotoxic chemotherapy does not have a significant role in the management of melanoma patients with brain metastases, neither alone nor in conjunction with radiation therapy. PATIENTS AND METHODS: We herein discuss a case of a 66-year-old male diagnosed initially with stage III-B melanoma and underwent a wide local excision with a split thickness graft and sentinel lymph node biopsy, followed by adjuvant treatment with high-dose interferon...
2016: Anticancer Research
https://www.readbyqxmd.com/read/27586680/primary-cerebral-malignant-melanoma-in-insular-region-with-extracranial-metastasis-case-report-and-review-literature
#19
REVIEW
Marta Troya-Castilla, Santiago Rocha-Romero, Yamin Chocrón-González, Francisco Javier Márquez-Rivas
BACKGROUND: Primary brain melanomas are very infrequent and metastasis outside central nervous system very uncommon. There are some cases in the literature about primary melanoma in the temporal lobe; nevertheless, the insular location has never been described. CASE PRESENTATION: The patient presented as left insular intraparenchymal hematoma with multiple bleedings. Complementary tests did not show any tumoral nor vascular pattern in relation with these bleedings...
September 1, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27413581/postoperative-cerebral-myiasis-a-rare-cause-of-wound-dehiscence-in-developing-countries
#20
Juliano N Navarro, Raphael V Alves
BACKGROUND: Cerebral myiasis is a rare parasitic disease, especially in postoperative neurological surgery. CASE DESCRIPTION: We report a case of postoperative myiasis in a patient who underwent a craniotomy for resection of metastatic melanoma, evolving with wound dehiscence due to myiasis in the operative wound. CONCLUSION: Myiasis infestation should be a differential diagnosis of surgical wound dehiscence, particularly when the classic signs of inflammation are not present and computed tomography of the brain shows signs suggestive of this disease entity...
2016: Surgical Neurology International
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