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https://www.readbyqxmd.com/read/29040479/quality-of-life-following-esophagectomy-with-three-field-lymphadenectomy-for-carcinoma-focusing-on-its-relationship-to-vocal-cord-palsy
#1
M Baba, T Aikou, S Natsugoe, C Kusano, M Shimada, S Nakano, T Fukumoto, H Yoshinaka
To clarify the quality of life of patients who underwent esophagectomy for carcinoma by right thoracotomy, laparotomy and cervical anastomosis, 116 patients who were cancer free at the time of mailing a questionnaire were analyzed. A significant decrease in vital capacity for 3 years postoperatively, as well as in the percentage of ideal body weight, between 3 and 5 years were observed in 57 patients with three-field lymphadenectomy. Patients' quality of life undergoing three-field dissection was worse than those with less radical lymphadenectomy (59 cases) in terms of the performance status and difficulty in talking at 60 months or more postoperatively...
November 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29040301/surveying-predictors-of-late-life-longitudinal-change-in-daily-activity-energy-expenditure
#2
Vincenzo Valiani, Sandrine Sourdet, Dale A Schoeller, Dawn C Mackey, Douglas C Bauer, Nancy W Glynn, Yosuke Yamada, Tamara B Harris, Todd M Manini
BACKGROUND: Total daily energy expenditure (TEE) is composed of resting metabolic rate (RMR), post-prandial thermogenesis and activity energy expenditure (AEE). Higher AEE is strongly associated with lower mortality and physical limitations among older adults, but factors that predict changes in AEE in septu and octogenarians are not clearly understood. OBJECTIVE: To identify factors associated with late-life longitudinal change in AEE. DESIGN: Energy expenditure was re-assessed in 83 participants (average age at baseline, 74...
2017: PloS One
https://www.readbyqxmd.com/read/29036797/effects-of-venotonic-drugs-on-the%C3%A2-microcirculation-comparison-between-ruscus-extract-and-micronized-diosmine1
#3
Fatima Zely Garcia de Almeida Cyrino, Daniela Signorelli Balthazar, Fernando Lencastre Sicuro, Eliete Bouskela
BACKGROUND: Chronic venous disease of the lower limbs is a common public health problem worldwide with negative impact on quality of life and results with drugs used to treat it are sparse, probably due to lack of good experimental models. OBJECTIVE: In this investigation we have tested the effects of two commonly used venotonic substances, Ruscus extract and micronized diosmine, on the microcirculation in vivo. METHODS: These substances were given orally, by gavage, during two weeks, twice daily and observations were made using the hamster cheek pouch preparation...
October 7, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29035638/evaluation-of-the-effectiveness-of-a-novel-gait-trainer-in-increasing-the-functionality-of-individuals-with-motor-impairment-a-case-series
#4
Eitan Raveh, Isabella Schwartz, Naama Karniel, Sigal Portnoy
Regaining the ability to independently ambulate following a physical disability can increase functional ability and participation of patients in daily life. Gait trainers are assistive devices that enable body support and provide safety during gait. However, most conventional gait trainers are pre-configured to a constant position, therefore not suitable for practicing sit-to-stand function, and require assistance from a caregiver in order to mount the device from a sitting position. We therefore evaluated the effectiveness of a dynamically-adjusting gait trainer, designed to provide independence and safety during gait and various activities, in both lab setting and at home in 4 subjects (1 female, 3 males, ages 32-79 years) with limited ambulation...
October 16, 2017: Assistive Technology: the Official Journal of RESNA
https://www.readbyqxmd.com/read/29035067/executive-functioning-in-relation-to-coping-in-mild-versus-moderate-severe-traumatic-brain-injury
#5
Sandra E Rakers, Myrthe E Scheenen, Herma J Westerhof-Evers, Myrthe E de Koning, Harm J van der Horn, Joukje van der Naalt, Jacoba M Spikman
OBJECTIVE: To examine associations between executive functioning (EF) and coping styles, separately for mild and moderate-severe traumatic brain injury (TBI) in the chronic phase postinjury. METHOD: Patients with mild (n = 47) and moderate-severe TBI (n = 59) were included, in addition to healthy controls (HCs; n = 51). Assessment consisted of EF tests (Trail Making Test, Zoo Map Test, Controlled Oral Word Association Test) and questionnaires examining EF (Dysexecutive Questionnaire) and coping styles (Utrecht Coping List)...
October 16, 2017: Neuropsychology
https://www.readbyqxmd.com/read/29034477/hybrid-bodies-and-the-materiality-of-everyday-life-how-people-living-with-pacemakers-and-defibrillators-reinvent-everyday-routines-and-intimate-relations
#6
Nelly Oudshoorn
Technologies inside bodies pose new challenges in a technological culture. For people with pacemakers and defibrillators, activities such as passing security controls at airports, using electromagnetic machines, electrical domestic appliances and electronic devices, and even intimate contacts with their loved ones can turn into events where the proper functioning of their device may be at risk. Anticipation of potentially harmful events and situations thus becomes an important part of the choreography of everyday life...
October 15, 2017: Sociology of Health & Illness
https://www.readbyqxmd.com/read/29033138/do-you-believe-it-verbal-suggestions-influence-the-clinical-and-neural-effects-of-escitalopram-in-social-anxiety-disorder-a-randomized-trial
#7
Vanda Faria, Malin Gingnell, Johanna M Hoppe, Olof Hjorth, Iman Alaie, Andreas Frick, Sara Hultberg, Kurt Wahlstedt, Jonas Engman, Kristoffer N T Månsson, Per Carlbring, Gerhard Andersson, Margareta Reis, Elna-Marie Larsson, Mats Fredrikson, Tomas Furmark
BACKGROUND: Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed for depression and anxiety, but their efficacy relative to placebo has been questioned. We aimed to test how manipulation of verbally induced expectancies, central for placebo, influences SSRI treatment outcome and brain activity in patients with social anxiety disorder (SAD). METHODS: We did a randomized clinical trial, within an academic medical center (Uppsala, Sweden), of individuals fulfilling the DSM-IV criteria for SAD, recruited through media advertising...
September 27, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29031538/everyday-stress-response-targets-in-the-science-of-behavior-change
#8
Joshua M Smyth, Martin J Sliwinski, Matthew J Zawadzki, Stacey B Scott, David E Conroy, Stephanie T Lanza, David Marcusson-Clavertz, Jinhyuk Kim, Robert S Stawski, Catherine M Stoney, Orfeu M Buxton, Christopher N Sciamanna, Paige M Green, David M Almeida
Stress is an established risk factor for negative health outcomes, and responses to everyday stress can interfere with health behaviors such as exercise and sleep. In accordance with the Science of Behavior Change (SOBC) program, we apply an experimental medicine approach to identifying stress response targets, developing stress response assays, intervening upon these targets, and testing intervention effectiveness. We evaluate an ecologically valid, within-person approach to measuring the deleterious effects of everyday stress on physical activity and sleep patterns, examining multiple stress response components (i...
September 28, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/29031386/impact-of-conjugated-linoleic-acid-administered-to-rats-prior-and-after-carcinogenic-agent-on-arachidonic-and-linoleic-acid-metabolites-in-serum-and-tumors
#9
Małgorzata Jelińska, Agnieszka Białek, Iwona Gielecińska, Hanna Mojska, Andrzej Tokarz
The objective of the study was to assess the influence of conjugated linoleic acid (CLA) daily supplementation prior and after carcinogenic agent on the concentrations of eicosanoids - metabolites of arachidonic acid (15-, 12- or 5-hydroxyeicosatetraenoic acids (15-, 12-, 5-HETE), prostaglandin E2 (PGE2)) and linoleic acid (13- or 9-hydroxyoctadecadienoic acids (13-, 9-HODE)) in rat serum and 7,12-dimethylbenz[a]anthracene (DMBA)-induced tumors. Female rats were randomised into six groups, receiving 1% or 2% Bio-C...
November 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29031317/emotional-state-and-psychological-flexibility-in-breast-cancer-survivors
#10
REVIEW
Sonia González-Fernández, Concepción Fernández-Rodríguez, María Jesús Mota-Alonso, Paula García-Teijido, Ignacio Pedrosa, Marino Pérez-Álvarez
PURPOSE: This study analyses the premise that less time spent carrying out valuable activities and inflexible avoidance of thoughts, feelings and memories related to the oncological process may play an important role in the emotional problems of cancer survivors. METHODS: Emotional state was evaluated, as was quality of life and psychological flexibility in a sample of 122 breast cancer survivors (Mage = 52.40; SDage = 7.26). The analysis was carried out using a cross-sectional predictive study...
October 2017: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/29030731/burden-of-migraine-in-a-kuwaiti-population-a-door-to-door-survey
#11
Jasem Yousef Al-Hashel, Samar Farouk Ahmed, Raed Alroughani
BACKGROUND: Migraine prevalence and disability imprints on Kuwaiti population are underreported. We aimed to measure the prevalence of migraine and to assess its burden in Kuwait. METHODS: A cross-sectional community-based study was conducted which included biologically unrelated Kuwaiti adult population aged 18-65 years. They were randomly recruited from all six governments of Kuwait using stratified multistage cluster sampling. Trained interviewers visited the samples in door-to-door approach...
October 13, 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29030502/injury-talk-spontaneous-parent-child-conversations-in-the-aftermath-of-a-potentially-traumatic-event
#12
Eva Alisic, Shaminka Gunaratnam, Anna Barrett, Rowena Conroy, Helen Jowett, Silvia Bressan, Franz E Babl, Roderick McClure, Vicki Anderson, Matthias R Mehl
BACKGROUND: While talking about traumatic experiences is considered central to psychological recovery, little is known about how these conversations occur in daily life. OBJECTIVE: We investigated spontaneous injury talk among parents and children in the aftermath of a child's hospitalisation due to physical trauma, and its relationship with children's socioemotional functioning. METHODS: In a prospective naturalistic observation study, we audio-sampled the daily life of 71 families with the Electronically Activated Recorder after their child (3-16 years old) was discharged from hospital...
October 13, 2017: Evidence-based Mental Health
https://www.readbyqxmd.com/read/29029646/paretic-versus-non-paretic-stepping-responses-following-pelvis-perturbations-in-walking-chronic-stage-stroke-survivors
#13
Juliet A M Haarman, Mark Vlutters, Richelle A C M Olde Keizer, Edwin H F van Asseldonk, Jaap H Buurke, Jasper Reenalda, Johan S Rietman, Herman van der Kooij
BACKGROUND: The effects of a stroke, such as hemiparesis, can severely hamper the ability to walk and to maintain balance during gait. Providing support to stroke survivors through a robotic exoskeleton, either to provide training or daily-life support, requires an understanding of the balance impairments that result from a stroke. Here, we investigate the differences between the paretic and non-paretic leg in making recovery steps to restore balance following a disturbance during walking...
October 13, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29029164/aging-parents-disabilities-and-daily-support-exchanges-with-middle-aged-children
#14
Meng Huo, Jamie L Graham, Kyungmin Kim, Steven H Zarit, Karen L Fingerman
Background and Objectives: Aging parents often incur disabilities in activities of daily living, which may limit their ability to give support and necessitate increased support from middle-aged children. Research has predominantly assessed disabled parents' retrospective reports of receiving support, but we know little about their daily support exchanges with middle-aged children. This study examined practical support, emotional support, and advice that aging parents with and without disabilities provided and received from middle-aged children, and links between these support exchanges and parents' daily mood...
September 23, 2017: Gerontologist
https://www.readbyqxmd.com/read/29028981/tofacitinib-in-patients-with-ulcerative-colitis-health-related-quality-of-life-in-phase%C3%A2-3-randomized-controlled-induction-and-maintenance-studies
#15
Julian Panés, Séverine Vermeire, James O Lindsay, Bruce E Sands, Chinyu Su, Gary Friedman, Haiying Zhang, Aaron Yarlas, Martha Bayliss, Stephen Maher, Joseph C Cappelleri, Andrew G Bushmakin, David T Rubin
Background and Aims: Tofacitinib is an oral, small molecule JAK inhibitor that is being investigated for UC. We evaluated healthrelated quality of life [HRQoL] in tofacitinib UC Phase 3 studies. Methods: Patients ≥18 years old in OCTAVE Induction 1 [N=598] and 2 [N=541] with moderately to severely active UC were randomized [1:4] to placebo or tofacitinib 10mg twice daily [BID] for 8 weeks. Subsequently, OCTAVE Sustain re-randomized [1:1:1] clinical responders [N=593] from induction studies to placebo, tofacitinib 5 or 10mg BID for 52 weeks...
September 27, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29028920/perceived-fatigability-and-objective-physical-activity-in-mid-to-late-life
#16
Amal A Wanigatunga, Eleanor M Simonsick, Vadim Zipunnikov, Adam P Spira, Stephanie Studenski, Luigi Ferrucci, Jennifer A Schrack
Background: Fatigability, defined as fatigue in relation to a standardized task, predicts functional decline in older adults independent of reported tiredness or energy level. Although the sensation of fatigue, tiredness, and energy level adversely affect physical activity (PA), the association between fatigability and objectively measured PA is unknown. Methods: Participants in the Baltimore Longitudinal Study of Aging (n=557, 50% women, aged 50-97) were instructed to wear an Actiheart accelerometer for 7 consecutive days in the free-living environment...
September 19, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29027973/smart-annotation-of-cyclic-data-using-hierarchical-hidden-markov-models
#17
Christine F Martindale, Florian Hoenig, Christina Strohrmann, Bjoern M Eskofier
Cyclic signals are an intrinsic part of daily life, such as human motion and heart activity. The detailed analysis of them is important for clinical applications such as pathological gait analysis and for sports applications such as performance analysis. Labeled training data for algorithms that analyze these cyclic data come at a high annotation cost due to only limited annotations available under laboratory conditions or requiring manual segmentation of the data under less restricted conditions. This paper presents a smart annotation method that reduces this cost of labeling for sensor-based data, which is applicable to data collected outside of strict laboratory conditions...
October 13, 2017: Sensors
https://www.readbyqxmd.com/read/29027853/intraoperative-test-stimulation-versus-stereotactic-accuracy-as-a-surgical-end-point-a-comparison-of-essential-tremor-outcomes-after-ventral-intermediate-nucleus-deep-brain-stimulation
#18
Tsinsue Chen, Zaman Mirzadeh, Kristina M Chapple, Margaret Lambert, Virgilio G H Evidente, Guillermo Moguel-Cobos, Srivadee Oravivattanakul, Padma Mahant, Francisco A Ponce
OBJECTIVE Ventral intermediate nucleus deep brain stimulation (DBS) for essential tremor is traditionally performed with intraoperative test stimulation and conscious sedation, without general anesthesia (GA). Recently, the authors reported retrospective data on 17 patients undergoing DBS after induction of GA with standardized anatomical coordinates on T1-weighted MRI sequences used for indirect targeting. Here, they compare prospectively collected data from essential tremor patients undergoing DBS both with GA and without GA (non-GA)...
October 13, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29027807/annals-express-biochemistry-of-the-menopause
#19
John W Honour
The life of a human female is characterised from teenage years by monthly menstruation which ceases (the menopause) typically between the age of 40 and 60 years. The potential for reproduction declines and ceases as the ovaries become depleted of follicles. A transition period in mid-life, for 2 to 10 years, when menstruation is less regular is called the peri-menopause. The menopause is associated with a significant decline in plasma concentrations of sex hormones, an increase in the concentrations of the gonadotrophins and changes in other hormones such as the inhibins...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29027539/fatigue-as-a-symptom-or-comorbidity-of-neurological-diseases
#20
REVIEW
Iris-Katharina Penner, Friedemann Paul
Fatigue, best described as an overwhelming feeling of tiredness and exhaustion, occurs in the context of various neurological diseases. The high prevalence of fatigue as either a symptom or a comorbidity of neurological disease must be taken seriously, as fatigue interferes with patients' activities of daily living, has a remarkable negative impact on quality of life, and is a major reason for early retirement. The tremendous consequences of fatigue are consistent across neurological diseases, as is the uncertainty concerning its underlying pathophysiological mechanisms...
October 13, 2017: Nature Reviews. Neurology
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