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https://www.readbyqxmd.com/read/28231311/handwashing-and-ebola-virus-disease-outbreaks-a-randomized-comparison-of-soap-hand-sanitizer-and-0-05-chlorine-solutions-on-the-inactivation-and-removal-of-model-organisms-phi6-and-e-coli-from-hands-and-persistence-in-rinse-water
#1
Marlene K Wolfe, Karin Gallandat, Kyle Daniels, Anne Marie Desmarais, Pamela Scheinman, Daniele Lantagne
To prevent Ebola transmission, frequent handwashing is recommended in Ebola Treatment Units and communities. However, little is known about which handwashing protocol is most efficacious. We evaluated six handwashing protocols (soap and water, alcohol-based hand sanitizer (ABHS), and 0.05% sodium dichloroisocyanurate, high-test hypochlorite, and stabilized and non-stabilized sodium hypochlorite solutions) for 1) efficacy of handwashing on the removal and inactivation of non-pathogenic model organisms and, 2) persistence of organisms in rinse water...
2017: PloS One
https://www.readbyqxmd.com/read/28230320/probability-of-success-for-phase-iii-after-exploratory-biomarker-analysis-in-phase-ii
#2
Heiko Götte, Marietta Kirchner, Martin Oliver Sailer
The probability of success or average power describes the potential of a future trial by weighting the power with a probability distribution of the treatment effect. The treatment effect estimate from a previous trial can be used to define such a distribution. During the development of targeted therapies, it is common practice to look for predictive biomarkers. The consequence is that the trial population for phase III is often selected on the basis of the most extreme result from phase II biomarker subgroup analyses...
February 23, 2017: Pharmaceutical Statistics
https://www.readbyqxmd.com/read/28228538/route-choice-in-pedestrians-determinants-for-initial-choices-and-revising-decisions
#3
Weichen Liao, Armel U Kemloh Wagoum, Nikolai W F Bode
In moving pedestrian crowds, the distribution of individuals over different available routes emerges from the decisions of individuals that may be influenced by the actions of others. Understanding this phenomenon not only is important for research into collective behaviour, but also has practical applications for building safety and event management. Here, we study the mechanisms underlying pedestrian route choice, focusing on how time-independent information, such as path lengths, and time-dependent information, such as queue lengths, affect both initial decisions and subsequent changes in route choices...
February 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28227869/simea-a-framework-for-simulating-neurons-on-multi-electrode-array
#4
Vafa Andalibi, Timo Aaltonen, Francois Christophe, Tommi Mikkonen, Vafa Andalibi, Timo Aaltonen, Francois Christophe, Tommi Mikkonen, Timo Aaltonen, Vafa Andalibi, Tommi Mikkonen, Francois Christophe
A Multi-Electrode Array (MEA) is a practical device for recording the extracellular activity of in-vitro biological culture. Such culture - for instance neurons - is prone to mistakes leading to irrelevant recordings or no recording at all. Additionally, with the expenses generated by in-vitro culture, minimizing risks is a must. This paper proposes a framework designed and implemented for simulating the spatial positioning of neuronal cultures on a MEA. The framework serves as a sandbox for researchers to simulate the model of their MEA experiments before its eventual in-vitro implementation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227795/simplified-realistic-human-head-model-for-simulating-tumor-treating-fields-ttfields
#5
Cornelia Wenger, Ze'ev Bomzon, Ricardo Salvador, Peter J Basser, Pedro C Miranda, Cornelia Wenger, Ze'ev Bomzon, Ricardo Salvador, Peter J Basser, Pedro C Miranda, Peter J Basser, Pedro C Miranda, Cornelia Wenger, Ricardo Salvador, Ze'ev Bomzon
Tumor Treating Fields (TTFields) are alternating electric fields in the intermediate frequency range (100-300 kHz) of low-intensity (1-3 V/cm). TTFields are an anti-mitotic treatment against solid tumors, which are approved for Glioblastoma Multiforme (GBM) patients. These electric fields are induced non-invasively by transducer arrays placed directly on the patient's scalp. Cell culture experiments showed that treatment efficacy is dependent on the induced field intensity. In clinical practice, a software called NovoTal(TM) uses head measurements to estimate the optimal array placement to maximize the electric field delivery to the tumor...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227467/a-simplified-state-space-model-of-biventricular-assist-device-cardiovascular-system-interaction
#6
Vivian C A Koh, Einly Lim, Boon Chiang Ng, Yong Kuen Ho, Nigel H Lovell, Vivian C A Koh, Einly Lim, Boon Chiang Ng, Yong Kuen Ho, Nigel H Lovell, Boon Chiang Ng, Einly Lim, Vivian C A Koh, Nigel H Lovell, Yong Kuen Ho
A simplified state-space model of biventricular assist device (BiVAD)-cardiovascular system (CVS) interaction is presented. The state-space equations includes a six-compartments CVS model incorporating the ventricles, the pulmonary and systemic circulations as well as the non-linear behavior of the valve flow, together with a left ventricular assist device (LVAD) and a right ventricular assist device (RVAD) component. The left and right pump speeds serve as the input variables for the state-space model. The model is simulated with three operational modes, i...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227290/pre-clinical-investigations-of-multi-path-propagation-in-transcranial-doppler-ultrasound-flow-phantom
#7
Alexander J Weir, Cheng-Xiang Wang, Stuart Parks, Alexander J Weir, Cheng-Xiang Wang, Stuart Parks, Alexander J Weir, Stuart Parks, Cheng-Xiang Wang
There are various practical situations in medical applications when pre-clinical investigations must be performed using a simulation environment or test bench prior to human studies. One example is the analysis of propagation channels in Transcanial Doppler (TCD) ultrasound (US), a signal processing challenge requiring the analysis of data from US waves scattered in three dimensions (3D). When examining the effects of scatterers in such channels, it is common to use a data acquisition test bench and a Doppler flow phantom...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227086/catheter-simulator-software-tool-to-generate-electrograms-of-any-multi-polar-diagnostic-catheter-from-3d-atrial-tissue
#8
Kristina E Shillieto, Prasanth Ganesan, Anthony J Salmin, Elizabeth M Cherry, Arkady M Pertsov, Behnaz Ghoraani, Kristina E Shillieto, Prasanth Ganesan, Anthony J Salmin, Elizabeth M Cherry, Arkady M Pertsov, Behnaz Ghoraani, Arkady M Pertsov, Behnaz Ghoraani, Anthony J Salmin, Kristina E Shillieto, Elizabeth M Cherry, Prasanth Ganesan
Simulations are excellent tools for assessing new therapeutic strategies and are often conducted before implementing new therapy options in a clinical practice. For patients suffering from a heart arrhythmia, the main source of information comes from an intracardiac catheter. One of the common catheters is a Lasso multi-pole diagnostic catheter, which is a catheter that has 20 electrodes in a circular pattern. In this paper, we developed algorithm and simulation software that allows the users to place a multi-pole catheter on the atrial endocardial surface and record electrograms...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227064/energy-based-metrics-for-laparoscopic-skills-assessment
#9
Behnaz Poursartip, Marie-Eve LeBel, Rajni V Patel, Michael D Naish, Ana Luisa Trejos, Behnaz Poursartip, Marie-Eve LeBel, Rajni V Patel, Michael D Naish, Ana Luisa Trejos, Rajni V Patel, Michael D Naish, Marie-Eve LeBel, Ana Luisa Trejos, Behnaz Poursartip
The growing popularity of minimally invasive surgery (MIS) can be attributed to its advantages, which include reduced post-operative pain, a shorter hospital stay, and faster recovery. However, MIS requires extensive training for surgeons to become experts in their field of practice. Different assessment methods have been proposed for evaluating the performance of surgeons and residents on surgical simulators. Nonetheless, optimal objective performance measures are still lacking. In this study, three metrics for minimally invasive skills assessment are proposed based on energy expenditure: work, potential energy and kinetic energy...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226933/development-of-artificial-tissue-like-structures-for-a-hybrid-epidural-anesthesia-simulator
#10
Benjamin Esterer, Johannes Razenbock, Marianne Hollensteiner, David Fuerst, Andreas Schrempf, Benjamin Esterer, Johannes Razenbock, Marianne Hollensteiner, David Fuerst, Andreas Schrempf, David Fuerst, Benjamin Esterer, Johannes Razenbock, Andreas Schrempf, Marianne Hollensteiner
Puncturing the epidural space and lumbar puncture are common procedures in anesthesia. They are carried out blind, where a needle is advanced from posterior between two adjacent vertebrae. Two different approaches are common practice for this technique, the midline and the paramedian one. The learning curve characteristics of both approaches significantly depends on the number of punctures carried out by a medical novice. For the training of these blind procedures a hybrid simulator requires artificial structures imitating the tissues which are penetrated by the needle...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226730/rf-induced-energy-for-partially-implanted-catheters-a-computational-study
#11
Elena Lucano, Micaela Liberti, Tom Lloyd, Francesca Apollonio, Steve Wedan, Wolfgang Kainz, Leonardo M Angelone, Elena Lucano, Micaela Liberti, Tom Lloyd, Francesca Apollonio, Steve Wedan, Wolfgang Kainz, Leonardo M Angelone, Elena Lucano, Leonardo M Angelone, Tom Lloyd, Steve Wedan, Francesca Apollonio, Wolfgang Kainz, Micaela Liberti
Magnetic Resonance Imaging (MRI) is a radiological imaging technique widely used in clinical practice. MRI has been proposed to guide the catheters for interventional procedures, such as cardiac ablation. However, there are risks associated with this procedure, such as RF-induced heating of tissue near the catheters. The aim of this study is to develop a quantitative RF-safety method for patients with partially implanted leads at 64 MHz. RF-induced heating is related to the electric field incident along the catheter, which in turns depends on several variables, including the position of the RF feeding sources and the orientation of the polarization, which are however often unknown...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226451/non-invasive-imaging-of-ventricular-activation-during-pacing-and-arrhythmia-methods-and-validation
#12
Long Yu, Steven Pogwizd, Bin He, Long Yu, Steven Pogwizd, Bin He, Bin He, Steven Pogwizd, Long Yu
Cardiovascular disease continued to be a leading killer world widely. Each year, about 400,000 cases of sudden cardiac arrest are reported in the U.S. alone. Clinically, radio-frequency ablative procedure has become widely applied in the treatment of ventricular arrhythmia. Non-invasive approaches have been demonstrated to be able to provide important information on the arrhythmogenesis and potentially assist in the clinical practice. In this work, we develop and validate a novel temporal sparse based imaging method, Cardiac Electrical Sparse Imaging (CESI)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226448/graph-fractional-order-total-variation-eeg-source-reconstruction
#13
Ying Li, Jing Qin, Stanley Osher, Wentai Liu, Ying Li, Jing Qin, Stanley Osher, Wentai Liu, Jing Qin, Stanley Osher, Ying Li, Wentai Liu
EEG source imaging is able to reconstruct sources in the brain from scalp measurements with high temporal resolution. Due to the limited number of sensors, it is very challenging to locate the source accurately with high spatial resolution. Recently, several total variation (TV) based methods have been proposed to explore sparsity of the source spatial gradients, which is based on the assumption that the source is constant at each subregion. However, since the sources have more complex structures in practice, these methods have difficulty in recovering the current density variation and locating source peaks...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226440/measuring-the-agreement-between-brain-connectivity-networks
#14
J Toppi, N Sciaraffa, Y Antonacci, A Anzolin, S Caschera, M Petti, D Mattia, L Astolfi, J Toppi, N Sciaraffa, Y Antonacci, A Anzolin, S Caschera, M Petti, D Mattia, L Astolfi, D Mattia, L Astolfi, Y Antonacci, A Anzolin, S Caschera, M Petti, N Sciaraffa, J Toppi
Investigating the level of similarity between two brain networks, resulting from measures of effective connectivity in the brain, can be of interest from many respects. In this study, we propose and test the idea to borrow measures of association used in machine learning to provide a measure of similarity between the structure of (un-weighted) brain connectivity networks. The measures here explored are the accuracy, Cohen's Kappa (K) and Area Under Curve (AUC). We implemented two simulation studies, reproducing two contexts of application that can be particularly interesting for practical applications, namely: i) in methodological studies, performed on surrogate data, aiming at comparing the estimated network with the corresponding ground-truth network; ii) in applications to real data, when it is necessary to compare the structure of a network obtained in a specific subject with a reference (e...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226262/an-urban-runoff-model-designed-to-inform-stormwater-management-decisions
#15
Nicole G Beck, Gary Conley, Lisa Kanner, Margaret Mathias
We present an urban runoff model designed for stormwater managers to quantify runoff reduction benefits of mitigation actions that has lower input data and user expertise requirements than most commonly used models. The stormwater tool to estimate load reductions (TELR) employs a semi-distributed approach, where landscape characteristics and process representation are spatially-lumped within urban catchments on the order of 100 acres (40 ha). Hydrologic computations use a set of metrics that describe a 30-year rainfall distribution, combined with well-tested algorithms for rainfall-runoff transformation and routing to generate average annual runoff estimates for each catchment...
February 19, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28225353/impact-of-fluorescence-emission-from-gold-atoms-on-surrounding-biological-tissue-implications-for-nanoparticle-radio-enhancement
#16
Hilary L Byrne, Yaser Gholami, Zdenka Kuncic
The addition of gold nanoparticles within target tissue (i.e. a tumour) to enhance the delivered radiation dose is a well studied radiotherapy treatment strategy, despite not yet having been translated into standard clinical practice. While several studies have used Monte Carlo simulations to investigate radiation dose enhancement by Auger electrons emitted from irradiated gold nanoparticles, none have yet considered the effects due to escaping fluorescence photons. Geant4 was used to simulate a water phantom containing 10 mg/mL uniformly dispersed gold (1% by mass) at 5cm depth...
February 22, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28225325/application-of-mental-skills-training-in-surgery-a-review-of-its-effectiveness-and-proposed-next-steps
#17
Nicholas E Anton, Eric A Bean, Samuel C Hammonds, Dimitrios Stefanidis
INTRODUCTION: Mental skills training, which refers to the teaching of performance enhancement and stress management psychological strategies, may benefit surgeons. Our objective was to review the application of mental skills training in surgery and contrast it to other domains, examine the effectiveness of this approach in enhancing surgical performance and reducing stress, and provide future directions for mental skills training in surgery. MATERIALS AND METHODS: A systematic literature search of MEDLINE, PubMed, PsycINFO, and ClinicalKey was performed between 1996 and 2016...
February 22, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28225251/silicone-infused-anti-smudge-nanocoatings
#18
Heng Hu, Jian Wang, Yu Wang, Emily Gee, Guojun Liu
A polyurethane-based NP-GLIDE coating that bears on its surface and in its interior nano-pools of a grafted liquid ingredient for dewetting enablement is obtained from casting and curing a film comprising a triisocyanate, a polyol (P1), and a graft (g) copolymer of P1 and poly(dimethyl siloxane) (P1-g-PDMS). A silicone-infused NP-GLIDE (SINP-GLIDE) PU coating is obtained from co-casting the NP-GLIDE precursors with a free silicone oil (SO) or SO mixture (SOs). This paper reports the preparation of the novel SINP-GLIDE coatings and discusses the effect of changing the amount and type of the infused SO as well as the coating formation conditions on their optical clarity...
February 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28224972/a-mathematical-model-for-the-two-learners-problem
#19
Jan Mueller, Carmen Vidaurre, Martijn Schreuder, Frank Meinecke, Paul von Bünau, Klaus-Robert Mueller
OBJECTIVE: We present the first generic theoretical formulation of the co-adaptive learning problem and give a simple example of two interacting linear learning systems, a human and a machine. APPROACH: After the description of the training protocol of the two learning systems, we define a simple linear model where the two learning agents are coupled by a joint loss function. The simplicity of the model allows us to find learning rules for both human and machine that permit computing theoretical simulations...
February 22, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28224441/does-medicaid-insurance-confer-adequate-access-to-adult-orthopaedic-care-in-the-era-of-the-patient-protection-and-affordable-care-act
#20
Joseph T Labrum, Taylor Paziuk, Theresa C Rihn, Alan S Hilibrand, Alexander R Vaccaro, Mitchell G Maltenfort, Jeffrey A Rihn
BACKGROUND: A current appraisal of access to orthopaedic care for the adult patient receiving Medicaid is important, since Medicaid expansion was written into law by the Patient Protection and Affordable Care Act (PPACA). QUESTIONS/PURPOSES: (1) Do orthopaedic practices provide varying access to orthopaedic care for simulated patients with Medicaid insurance versus private insurance in a blinded survey? (2) What are the surveyed state-by-state Medicaid acceptance rates for adult orthopaedic practices in the current era of Medicaid expansion set forth by the PPACA? (3) Do surveyed rates of access to orthopaedic care in the adult patient population vary across practice setting (private vs academic) or vary with different Medicaid physician reimbursement rates? (4) Are there differences in the surveyed Medicaid acceptance rates for adult orthopaedic practices in states that have expanded Medicaid coverage versus states that have foregone expansion? METHODS: Simulated Patient Survey: We performed a telephone survey study of orthopaedic offices in four states with Medicaid expansion...
February 21, 2017: Clinical Orthopaedics and related Research
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