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Paracoccidioides brasiliensis

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https://www.readbyqxmd.com/read/29780375/effect-of-artinm-on-human-blood-cells-during-infection-with-paracoccidioides-brasiliensis
#1
Luciana P Ruas, Livia M Genaro, Amauri S Justo-Junior, Lilian O Coser, Lívia F de Castro, Plinio Trabasso, Ronei L Mamoni, Maria-Cristina Roque-Barreira, Maria-Heloisa S L Blotta
Infections caused by fungi are prominent in our environment and can be potentially fatal. paracoccidioidomycosis (PCM), caused by fungi of the Paracoccidioides genus, is the most frequent systemic mycosis in Brazil and the main cause of death among immunocompetent individuals. The antifungal therapy for PCM is usually effective but side effects and relapses are often reported. The latter could be avoided with alternative or complementary therapies aimed at boosting the immune response to combat this pathogen...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29746940/nlrp3-inflammasome-is-involved-in-the-recognition-of-paracoccidioides-brasiliensis-by-human-dendritic-cells-and-in-the-induction-of-th17-cells
#2
Lívia Furquim de Castro, Larissa Nara Alegrini Longhi, Munir Regini Paião, Amauri da Silva Justo-Júnior, Marcelo Bispo de Jesus, Maria Heloisa de Souza Lima Blotta, Ronei Luciano Mamoni
OBJECTIVES: To investigate the involvement of NLRP3 in the effector functions of human dendritic cells (DCs) in response to Paracoccidioides brasiliensis yeast cells (Pb) and to evaluate its role in the modulation of the adaptive immune response. METHODS: DCs were differentiated from purified peripheral blood monocytes and analyzed in relation to the participation of TLR-2, dectin-1, and Syk in Pb recognition, as well as, the indirect mechanisms (Reactive Oxygen Species production, endosome acidification, or K+ efflux) involved in NLRP3 inflammasome activation after the stimulus with Pb...
May 7, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29733463/paracoccidioides-restrepiensis-b339-ps3-and-p-lutzii-ldr2-yeast-cells-and-soluble-components-display-in-vitro-hemolytic-and-hemagglutinating-activities-on-human-erythrocytes
#3
Fernando Cezar-Dos-Santos, Adriane Lenhard-Vidal, João Paulo Assolini, Audrey de Souza Marquez, Mário Augusto Ono, Eiko Nakagawa Itano
Paracoccidioidomycosis (PCM) is a systemic mycosis caused by thermodimorfic fungi of Paracoccidioides species complex. Several pathogenic fungi produce hemagglutinins and hemolysins, which are virulence factors involved in adhesion of pathogens to host tissues or cells and in destruction of erythrocytes. The present research investigated hemolytic and hemagglutinating activities of yeast cells and soluble components from P. restrepiensis (PS3; former P. brasiliensis B339) and P. lutzii (LDR2). Different concentrations of live and heat-killed yeast cells and soluble components from cell free antigen preparation (CFA) (native or heated - 56 and 100 °C, 30 min) were mixed with 1% human erythrocyte suspension...
May 7, 2018: Microbiology and Immunology
https://www.readbyqxmd.com/read/29706133/intestinal-paracoccidioidomycosis-resembling-crohn-s-disease-in-a-teenager-a-case-report
#4
Elizete Aparecida Lomazi, Leandro Minatel Vidal de Negreiros, Pedro Vitor Veiga Silva Magalhães, Raquel de Castro Siqueira Togni, Nielce Maria de Paiva, Antonio Fernando Ribeiro, Raquel Franco Leal
BACKGROUND: Differential diagnosis of inflammatory bowel disease is often very challenging. Paracoccidioidomycosis is a fungal disease that can mimic manifestations of Crohn's disease. CASE PRESENTATION: We report a case of a 13-year-old Caucasian boy with abdominal pain for 1.5 years associated with nausea, diarrhea, and weight loss of 10 kg. He presented increased C-reactive protein and an increased erythrocyte sedimentation rate. A colonoscopy showed deep serpiginous ulcers throughout his entire colon and rectum, which suggested Crohn's disease...
April 30, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29626797/synthesis-molecular-modeling-studies-and-evaluation-of-antifungal-activity-of-a-novel-series-of-thiazole-derivatives
#5
Cleudiomar Inácio Lino, Igor Gonçalves de Souza, Beatriz Martins Borelli, Thelma Tirone Silvério Matos, Iasmin Natália Santos Teixeira, Jonas Pereira Ramos, Elaine Maria de Souza Fagundes, Philipe de Oliveira Fernandes, Vinícius Gonçalves Maltarollo, Susana Johann, Renata Barbosa de Oliveira
In the search for new antifungal agents, a novel series of fifteen hydrazine-thiazole derivatives was synthesized and assayed in vitro against six clinically important Candida and Cryptococcus species and Paracoccidioides brasiliensis. Eight compounds showed promising antifungal activity with minimum inhibitory concentration (MIC) values ranging from 0.45 to 31.2 μM, some of them being equally or more active than the drug fluconazole and amphotericin B. Active compounds were additionally tested for toxicity against human embryonic kidney (HEK-293) cells and none of them exhibited significant cytotoxicity, indicating high selectivity...
March 31, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29616019/the-syk-coupled-c-type-lectin-receptors-dectin-2-and-dectin-3-are-involved-in-paracoccidioides-brasiliensis-recognition-by-human-plasmacytoid-dendritic-cells
#6
Nycolas Willian Preite, Claudia Feriotti, Dhêmerson Souza de Lima, Bruno Borges da Silva, Antônio Condino-Neto, Alessandra Pontillo, Vera Lúcia Garcia Calich, Flávio Vieira Loures
Plasmacytoid dendritic cells (pDCs), which have been extensively studied in the context of the immune response to viruses, have recently been implicated in host defense mechanisms against fungal infections. Nevertheless, the involvement of human pDCs during paracoccidioidomycosis (PCM), a fungal infection endemic to Latin America, has been scarcely studied. However, pDCs were found in the cutaneous lesions of PCM patients, and in pulmonary model of murine PCM these cells were shown to control disease severity...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29575049/molecular-detection-of-fungi-of-public-health-importance-in-wild-animals-from-southern-brazil
#7
Debora de Oliveira Losnak, Francielle Ramalho Rocha, Barbara Suares de Almeida, Keila Zaniboni Siqueira Batista, Sérgio Luiz Althoff, Josiane Haupt, Luciana Da Silva Ruiz, Laís Anversa, Simone Baldini Lucheis, Laís Moraes Paiz, Maria Rita Donalisio, Virginia Bodelão Richini Pereira
BACKGROUND: Some animals have an important relationship with fungal infections, and searching for pathogens in animal samples may be an opportunity for eco-epidemiological research. Since studies involving wildlife are generally restricted, using samples from road kills is an alternative. OBJECTIVES: The aim of this study was to verify whether pathogenic fungi of public health importance occur in wildlife road kills from Santa Catarina State, Brazil. METHODS: Organ samples (n=1063) from 297 animals were analyzed according to Polymerase Chain Reaction (PCR) using universal primers to detect fungi in general and, subsequently, using primers specific to Paracoccidioides brasiliensis, Histoplasma capsulatum and Cryptococcus spp...
March 25, 2018: Mycoses
https://www.readbyqxmd.com/read/29531572/-cokeromyces-recurvatus-in-a-papanicolaou-test-an-exceedingly-rare-finding-that-can-be-mistaken-for-paracoccidioides-brasiliensis
#8
Ninu Sharma, Joseph D Schwartzman, Edward J Gutmann, Jonathan D Marotti, Xiaoying Liu
Cokeromyces recurvatus is a zygomycetes yeast form that is very rarely detected in Papanicolaou (Pap) tests, in which it typically represents an innocuous colonizer. Its morphology closely resembles that of the better known Paracoccidioides brasiliensis , which can disseminate widely and cause clinically significant disease. We present a case of C. recurvatus detected in a cervical liquid-based preparation obtained from a 38-year old healthy woman. Careful cytomorphologic evaluation, in combination with culture and molecular techniques, was utilized to make a diagnosis and prevent the misdiagnosis of P...
2018: CytoJournal
https://www.readbyqxmd.com/read/29518446/inhibition-of-protein-kinase-a-affects-paracoccidioides-lutzii-dimorphism
#9
Sheila J Sestari, Wesley A Brito, Bruno J Neves, Celia M A Soares, Silvia M Salem-Izacc
A critical step in the lifecycle of many fungal pathogens is the ability to switch between filamentous and yeast growth, a process known as dimorphism. cAMP-dependent protein kinase (PKA) controls morphological changes and the pathogenicity of several animal and plant pathogenic fungi. In this work, we report the analysis of PKA activity during the mycelium to yeast transition in the pathogenic fungus Paracoccidioides lutzii. This fungus, as well as the closely related species Paracoccidioides brasiliensis, causes paracoccidioidomycosis, a systemic mycosis that affects thousands of people in Latin America...
July 1, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29513831/fatal-septic-shock-caused-by-paracoccidioides-brasiliensis-phylogenetic-species-s1-in-a-young-immunocompetent-patient-a-case-report
#10
Priscila Marques de Macedo, Rodrigo Almeida-Paes, Marcos de Abreu Almeida, Rowena Alves Coelho, Marcio Amaral de Oliveira Filho, Denise Machado Medeiros, Adriano Gomes-Silva, Jéssica Ribeiro de Lima, Alda Maria Da-Cruz, Rosely Maria Zancopé-Oliveira, Antonio Carlos Francesconi do Valle
The authors report the first case of fatal septic shock, a rare clinical presentation of paracoccidioidomycosis (PCM) caused by Paracoccidioides brasiliensis S1. We also provide an immunological evaluation of the patient. Severe clinical signs such as organ dysfunction and digital gangrene occurred in this case. The patient presented a remarkable cell activation profile and diminished percentage of peripheral blood T regulatory cells. A decrease in anti-inflammatory IL-1RA plasma level showed the potential for endothelium damage, probably contributing to a vasculitis process...
January 2018: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29476307/paracoccidioides-brasiliensis-infection-mimicking-recurrent-hodgkin-lymphoma-a-case-report-and-review-of-the-literature
#11
Ayaz Ghani, Molly Weinberg, Nusrat Pathan, Ramapriya Vidhun, Steven Sieber
Paracoccidioides infection is a rare entity in the USA. This dimorphic fungus is found in Central and South America and is thought to be acquired by inhalation through the soil. We report a case of Paracoccidioides brasiliensis infection presenting as a clavicular bone lesion, peripancreatic mass, and various skin lesions. A 35-year-old man with a history significant for Hodgkin lymphoma presented with a left clavicular mass that was suspected clinically and radiologically as recurrent Hodgkin lymphoma. He was not experiencing any associated symptoms and was undergoing chemotherapy treatment for his known Hodgkin disease...
February 23, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29467760/microrna-regulation-of-host-immune-responses-following-fungal-exposure
#12
REVIEW
Tara L Croston, Angela R Lemons, Donald H Beezhold, Brett J Green
Fungal bioaerosols are ubiquitous in the environment and human exposure can result in a variety of health effects ranging from systemic, subcutaneous, and cutaneous infections to respiratory morbidity including allergy, asthma, and hypersensitivity pneumonitis. Recent research has focused on the role of microRNAs (miRNAs) following fungal exposure and is overlooked, yet important, group of regulators capable of influencing fungal immune responses through a variety of cellular mechanisms. These small non-coding ribose nucleic acids function to regulate gene expression at the post-transcriptional level and have been shown to participate in multiple disease pathways including cancer, heart disease, apoptosis, as well as immune responses to microbial hazards and occupational allergens...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29420794/itraconazole-in-combination-with-neutrophil-depletion-reduces-the-expression-of-genes-related-to-pulmonary-fibrosis-in-an-experimental-model-of-paracoccidioidomycosis
#13
Juan David Puerta-Arias, Paula Andrea Pino-Tamayo, Julián Camilo Arango, Lina María Salazar-Peláez, Angel González
Itraconazole (ITC) is the drug of choice for treating paracoccidioidomycosis (PCM); nonetheless, patients with the chronic form of this mycosis develop fibrosis, a residual pulmonary abnormality, even after treatment. Recently, we observed that the depletion of neutrophils with a specific monoclonal antibody (mAb-anti-Ly6G) during the chronic stages of PCM was associated with a decrease in the fungal burden, the inflammatory response and a reduction of fibrosis. Herein, we aimed to evaluate the effect of ITC in combination with the mAb-anti-Ly6G in an experimental model of pulmonary PCM...
October 9, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29412355/paracoccidioidomycosis-due-to-paracoccidioides-brasiliensis-s1-plus-hiv-co-infection
#14
Priscila Marques de Macedo, Rodrigo Almeida-Paes, Marcos de Abreu Almeida, Rowena Alves Coelho, Hugo Boechat Andrade, Ana Beatriz Teixeira Brandão Camello Ferreira, Rosely Maria Zancopé-Oliveira, Antonio Carlos Francesconi do Valle
BACKGROUND: Paracoccidioidomycosis (PCM) is one of the most important systemic mycoses in Latin America and the leading fungal cause of mortality in non-immunosuppressed individuals in Brazil. However, HIV/PCM co-infection can increase the clinical severity in these co-infected patients. This co-infection is rarely reported in the literature mainly because of the different epidemiological profiles of these infections. Furthermore, PCM is a neglected and non-notifiable disease, which may underestimate the real importance of this disease...
March 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29409063/recovery-of-the-paracoccidioides-brasiliensis-virulence-after-animal-passage-promotes-changes-in-the-antioxidant-repertoire-of-the-fungus
#15
Daniele G Castilho, Marina V Navarro, Alison F A Chaves, Patricia Xander, Wagner L Batista
Paracoccidioides brasiliensis is the agent of paracoccidioidomycosis (PCM), a cause of disease in healthy and immunocompromised persons in Latin America. The infection begins after inhalation of the fungal propagules and their thermo-dimorphic shift to yeast form. The development of the disease depends on factors associated with the host immune response and the infectious agent's characteristics, especially virulence. The oxidative stress response is an important virulence attribute in several fungi. In this study, we assessed the enzymatic repertoire of responses to oxidative stress in the Pb18 isolate with different degrees of virulence...
March 1, 2018: FEMS Yeast Research
https://www.readbyqxmd.com/read/29405111/case-report-misleading-serological-diagnosis-of-paracoccidioidomycosis-in-a-young-patient-with-the-acute-form-disease-paracoccidioides-brasiliensis-or-paracoccidioides-lutzii
#16
Renata Buccheri, Vanessa Dos Santos Morais, Camila Mika Kamikawa, Monica Scarpelli Martinelli Vidal, Gabriel Naves, Gilda Maria Barbaro Del Negro, Adriana Pardini Vicentini, Gil Benard
Negative results in serological routine screening of patients with microbiologically proven Paracoccidioidomycosis (PCM) are occasionally reported. Failure in detecting anti- Paracoccidioides antibodies has been ascribed to factors either related to serological techniques or to the status of the host immune reactivity. Recently, this issue has been renewed by the recognition that the Paracoccidioides genera comprises two species, lutzii and brasiliensis , which have distinct antigenic profiles and, therefore, may elicit different host antibody responses...
April 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29361158/evaluation-of-caenorhabditis-elegans-as-a-host-model-for-paracoccidioides-brasiliensis-and-paracoccidioides-lutzii
#17
Liliana Scorzoni, Maria Pilar de Lucas, Junya de Lacorte Singulani, Haroldo Cesar de Oliveira, Patricia Akemi Assato, Ana Marisa Fusco-Almeida, Maria José Soares Mendes-Giannini
Paracoccidioidomycosis is a systemic fungal infection affecting mainly Latin American countries that is caused by Paracoccidioides brasiliensis and Paracoccidioides lutzii. During the study of fungal pathogenesis, in vivo studies are crucial to understand the overall mechanisms involving the infection as well as to search for new therapeutic treatments and diagnosis. Caenorhabditis elegans is described as an infection model for different fungi species and a well-characterized organism to study the innate immune response...
February 1, 2018: Pathogens and Disease
https://www.readbyqxmd.com/read/29325170/ecology-of-paracoccidioides-brasiliensis-p-lutzii-and-related-species-infection-in-armadillos-soil-occurrence-and-mycological-aspects
#18
Marluce Francisca Hrycyk, Hans Garcia Garces, Sandra de Moraes Gimenes Bosco, Sílvio Luis de Oliveira, Sílvio Alencar Marques, Eduardo Bagagli
Paracoccidioides brasiliensis and the related species P. americana, P. restrepiensis, P. venezuelensis, and P. lutzii (Ascomycota, Ajellomycetaceae) are the etiological agents of paracoccidoidoimycosis (PCM), one of the most important systemic mycoses in Latin America. They are dimorphic fungi, with a mycelial life cycle in soil and a yeast phase associated with tissues of mammalian hosts. This study aimed to detect Paracoccidioides spp. in armadillo tissues and associated soil samples in three well-defined geographic areas, including the Alta Floresta, an area not only endemic for PCM in the central region of Brazil but also of probable P...
January 6, 2018: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29300307/chemical-composition-and-bioactivity-of-essential-oil-from-blepharocalyx-salicifolius
#19
Fabiana Barcelos Furtado, Bruna Cristina Borges, Thaise Lara Teixeira, Hans Garcia Garces, Luiz Domingues de Almeida Junior, Fernanda Cristina Bérgamo Alves, Claudio Vieira da Silva, Ary Fernandes Junior
Natural products represent a source of biologically active molecules that have an important role in drug discovery. The aromatic plant Blepharocalyx salicifolius has a diverse chemical constitution but the biological activities of its essential oils have not been thoroughly investigated. The aims of this paper were to evaluate in vitro cytotoxic, antifungal and antibacterial activities of an essential oil from leaves of B. salicifolius and to identify its main chemical constituents. The essential oil was extracted by steam distillation, chemical composition was determined by gas chromatography/mass spectrometry, and biological activities were performed by a microdilution broth method...
January 4, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29230201/differential-metabolism-of-a-two-carbon-substrate-by-members-of-the-paracoccidioides-genus
#20
Lilian C Baeza, Fabiana R da Mata, Laurine L Pigosso, Maristela Pereira, Gustavo H M F de Souza, Alexandre S G Coelho, Célia M de Almeida Soares
The genus Paracoccidioides comprises known fungal pathogens of humans and can be isolated from different infection sites. Metabolic peculiarities in different members of the Paracoccidioides led us to perform proteomic studies in the presence of the two-carbon molecule acetate, which predominates in the nutrient-poor environment of the phagosome. To investigate the expression rates of proteins of different members of Paracoccidioides , including one isolate of P. lutzii ( Pb 01) and three isolates of P. brasiliensis ( Pb 03, Pb 339, and Pb EPM83), using sodium acetate as a carbon source, proteins were quantified using label-free and data-independent liquid chromatography-mass spectrometry...
2017: Frontiers in Microbiology
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