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https://www.readbyqxmd.com/read/29750921/editorial-comment
#1
Eric Winquist
No abstract text is available yet for this article.
May 8, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29737441/long-term-supportive-housing-is-associated-with-decreased-risk-for-new-hiv-diagnoses-among-a-large-cohort-of-homeless-persons-in-new-york-city
#2
Christopher T Lee, Andrea Winquist, Ellen W Wiewel, Sarah Braunstein, Hannah T Jordan, L Hannah Gould, R Charon Gwynn, Sungwoo Lim
It is unknown whether providing housing to persons experiencing homelessness decreases HIV risk. Housing, including access to preventive services and counseling, might provide a period of transition for persons with HIV risk factors. We assessed whether the new HIV diagnosis rate was associated with duration of supportive housing. We linked data from a cohort of 21,689 persons without a previous HIV diagnosis who applied to a supportive housing program in New York City (NYC) during 2007-2013 to the NYC HIV surveillance registry...
May 8, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29629866/prognostic-and-predictive-clinical-factors-in-patients-with-metastatic-castration-resistant-prostate-cancer-treated-with-cabazitaxel
#3
Daniel W Yokom, John Stewart, Nimira S Alimohamed, Eric Winquist, Scott Berry, Stacey Hubay, Jean-Baptiste Lattouf, Helene Leonard, Carla Girolametto, Fred Saad, Srikala S Sridhar
INTRODUCTION: Cabazitaxel is one of several treatment options available for patients with metastatic castration-resistant prostate cancer who have progressed on docetaxel. Little is known about clinical factors that influence prognosis or treatment response for patients receiving cabazitaxel. Identifying prognostic and predictive factors could contribute to the optimal selection of patients for treatment after docetaxel. METHODS: A retrospective review of patients enrolled on the cabazitaxel Canadian Early Access Program (C-EAP) was performed...
April 6, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29623630/the-potential-clinical-and-economic-value-of-primary-tumour-identification-in-metastatic-cancer-of-unknown-primary-tumour-a-population-based-retrospective-matched-cohort-study
#4
Malek B Hannouf, Eric Winquist, Salaheddin M Mahmud, Muriel Brackstone, Sisira Sarma, George Rodrigues, Peter K Rogan, Jeffrey S Hoch, Gregory S Zaric
PURPOSE: Several genomic tests have recently been developed to identify the primary tumour in cancer of unknown primary tumour (CUP). However, the value of identifying the primary tumour in clinical practice for CUP patients remains questionable and difficult to prove in randomized trials. OBJECTIVE: We aimed to assess the clinical and economic value of primary tumour identification in CUP using a retrospective matched cohort study. METHODS: We used the Manitoba Cancer Registry to identify all patients initially diagnosed with metastatic cancer between 2002 and 2011...
September 6, 2017: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29596642/the-dna-damage-response-activates-hpv16-late-gene-expression-at-the-level-of-rna-processing
#5
Kersti Nilsson, Chengjun Wu, Naoko Kajitani, Haoran Yu, Efthymios Tsimtsirakis, Lijing Gong, Ellenor B Winquist, Jacob Glahder, Lars Ekblad, Johan Wennerberg, Stefan Schwartz
We show that the alkylating cancer drug melphalan activated the DNA damage response and induced human papillomavirus type 16 (HPV16) late gene expression in an ATM- and Chk1/2-dependent manner. Activation of HPV16 late gene expression included inhibition of the HPV16 early polyadenylation signal that resulted in read-through into the late region of HPV16. This was followed by activation of the exclusively late, HPV16 splice sites SD3632 and SA5639 and production of spliced late L1 mRNAs. Altered HPV16 mRNA processing was paralleled by increased association of phosphorylated BRCA1, BARD1, BCLAF1 and TRAP150 with HPV16 DNA, and increased association of RNA processing factors U2AF65 and hnRNP C with HPV16 mRNAs...
March 27, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29507486/the-impact-of-seasonal-operating-room-closures-on-wait-times-for-oral-cancer-surgery
#6
N Mundi, J Theurer, A Warner, J Yoo, K Fung, D MacNeil, S Dhaliwal, E Winquist, D A Palma, A C Nichols
Background: Operating room slowdowns occur at specific intervals in the year as a cost-saving measure. We aim to investigate the impact of these slowdowns on the care of oral cavity cancer patients at a Canadian tertiary care centre. Methods: A total of 585 oral cavity cancer patients seen between 1999 and 2015 at the London Health Science Centre (lhsc) Head and Neck Multidisciplinary Clinic were included in this study. Operating room hours and patient load from 2006 to 2014 were calculated...
February 2018: Current Oncology
https://www.readbyqxmd.com/read/29487723/a-randomized-phase-ii-study-of-pelareorep-and-docetaxel-or-docetaxel-alone-in-men-with-metastatic-castration-resistant-prostate-cancer-cctg-study-ind-209
#7
Bernhard Josef Eigl, Kim Chi, Dongsheng Tu, Sebastien J Hotte, Eric Winquist, Christopher M Booth, Christina Canil, Kylea Potvin, Richard Gregg, Scott North, Muhammad Zulfiqar, Susan Ellard, Joseph Dean Ruether, Lyly Le, A Saranya Kakumanu, Mohammad Salim, Alison L Allan, Harriet Feilotter, Ashley Theis, Lesley Seymour
Background: Pelareorep is an oncolytic virus with activity in many cancers including prostate. It has in vitro synergism with microtubule-targeted agents. We undertook a clinical trial evaluating pelareorep in mCRPC patients receiving docetaxel. Patients and Methods: In this randomized, open-label phase II study, patients received docetaxel 75mg/m2 on day 1 of a 21-day cycle and prednisone 5mg twice daily, in combination with pelareorep (arm A) or alone (arm B)...
January 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29428550/a-new-model-to-predict-benign-histology-in-residual-retroperitoneal-masses-after-chemotherapy-in-nonseminoma
#8
Ricardo Leão, Madhur Nayan, Nahid Punjani, Michael A S Jewett, Kamel Fadaak, Juan Garisto, Jeremy Lewin, Eshetu G Atenafu, Joan Sweet, Lynn Anson-Cartwright, Peter Boström, Peter Chung, Padraig Warde, Philippe L Bedard, Aditya Bagrodia, Yuval Freifeld, Nicholas Power, Eric Winquist, Robert J Hamilton
BACKGROUND: Postchemotherapy retroperitoneal lymph node dissection (pcRPLND) is indicated in testicular cancer patients with normalised or plateaued serum tumour markers and residual retroperitoneal lesions >1cm. Challenges remain in predicting postchemotherapy residual mass (pcRM) histology, which may lead to unnecessary surgery. OBJECTIVE: To develop an accurate model to predict pcRM histology in patients with nonseminomatous germ cell tumours (NSGCTs). DESIGN, SETTING, AND PARTICIPANTS: A retrospective review of 335 patients undergoing pcRPLND for metastatic NSGCTs to develop a model to predict benign histology in retroperitoneal pcRM...
February 7, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29401087/nail-fit-does-nail-diameter-to-canal-ratio-predict-the-need-for-exchange-nailing-in-the-setting-of-aseptic-hypertrophic-femoral-nonunions
#9
Michael J Millar, Andrew Wilkinson, Pierre Navarre, Joel Steiner, Ashray Vohora, Andrew Hardidge, Elton Edwards
OBJECTIVES: To evaluate patient-independent risk factors for aseptic femoral hypertrophic nonunion requiring exchange nailing, with particular reference to the fit of the nail at the isthmus within the canal. DESIGN: Retrospective case control study. SETTING: Level 1 trauma center. MAIN OUTCOME MEASUREMENTS: Between 2008 and 2012, 211 patients without any patient-dependent risk factors for nonunion were treated with a locked reamed intramedullary nail for a femoral shaft fracture...
May 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29217465/heavy-precipitation-as-a-risk-factor-for-shigellosis-among-homeless-persons-during-an-outbreak-oregon-2015-2016
#10
Jonas Z Hines, Meredith A Jagger, Thomas L Jeanne, Nicole West, Andrea Winquist, Byron F Robinson, Richard F Leman, Katrina Hedberg
OBJECTIVES: Shigella species are the third most common cause of bacterial gastroenteritis in the United States. During a Shigella sonnei outbreak in Oregon from July 2015 through June 2016, Shigella cases spread among homeless persons with onset of the wettest rainy season on record. METHODS: We conducted time series analyses using Poisson regression to determine if a temporal association between precipitation and shigellosis incidence existed. Models were stratified by housing status...
March 2018: Journal of Infection
https://www.readbyqxmd.com/read/29089807/the-clinical-significance-of-occult-gynecologic-primary-tumours-in-metastatic-cancer
#11
M B Hannouf, E Winquist, S M Mahmud, M Brackstone, S Sarma, G Rodrigues, P K Rogan, J S Hoch, G S Zaric
OBJECTIVE: We estimated the frequency of occult gynecologic primary tumours (gpts) in patients with metastatic cancer from an uncertain primary and evaluated the effect on disease management and overall survival (os). METHODS: We used Manitoba administrative health databases to identify all patients initially diagnosed with metastatic cancer during 2002-2011. We defined patients as having an "occult" primary tumour if the primary was classified at least 6 months after the initial diagnosis...
October 2017: Current Oncology
https://www.readbyqxmd.com/read/29072563/case-secondary-polycythemia-due-to-pazopanib-in-patients-with-metastatic-renal-cell-carcinoma
#12
Nedal Bukhari, Eric Winquist
No abstract text is available yet for this article.
November 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29069723/repurposing-albendazole-new-potential-as-a-chemotherapeutic-agent-with-preferential-activity-against-hpv-negative-head-and-neck-squamous-cell-cancer
#13
Farhad Ghasemi, Morgan Black, Frederick Vizeacoumar, Nicole Pinto, Kara M Ruicci, Carson Cao Son Huu Le, Matthew R Lowerison, Hon Sing Leong, John Yoo, Kevin Fung, Danielle MacNeil, David A Palma, Eric Winquist, Joe S Mymryk, Paul C Boutros, Alessandro Datti, John W Barrett, Anthony C Nichols
Albendazole is an anti-helminthic drug that has been shown to exhibit anti-cancer properties, however its activity in head and neck squamous cell cancer (HNSCC) was unknown. Using a series of in vitro assays, we assessed the ability of albendazole to inhibit proliferation in 20 HNSCC cell lines across a range of albendazole doses (1 nM-10 μM). Cell lines that responded to treatment were further examined for cell death, inhibition of migration and cell cycle arrest. Thirteen of fourteen human papillomavirus-negative HNSCC cell lines responded to albendazole, with an average IC50 of 152 nM...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28868015/chronic-oxaliplatin-based-chemotherapy-in-a-primary-ampullary-adenocarcinoma-patient-without-significant-peripheral-neuropathy-case-report-and-literature-review
#14
Nedal Bukhari, Eric Winquist
Peripheral neuropathy is the most common dose-limiting toxicity associated with oxaliplatin. We report on a 61-year-old female patient with advanced primary ampullary adenocarcinoma who received 35 cycles of FOLFIRINOX (5-fluorouracil, irinotecan, and oxaliplatin) chemotherapy. The patient has tolerated this treatment without developing significant peripheral neuropathy.
May 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28629422/erratum-to-ozone-and-childhood-respiratory-disease-in-three-us-cities-evaluation-of-effect-measure-modification-by-neighborhood-socioeconomic-status-using-a-bayesian-hierarchical-approach
#15
Cassandra R O' Lenick, Howard H Chang, Michael R Kramer, Andrea Winquist, James A Mulholland, Mariel D Friberg, Stefanie Ebelt Sarnat
No abstract text is available yet for this article.
June 19, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28625005/dose-dense-mvac-prior-to-radical-cystectomy-a-real-world-experience
#16
Homayoun Zargar, Jay B Shah, Elisabeth E Fransen van de Putte, Kylea R Potvin, Kamran Zargar-Shoshtari, Bas W van Rhijn, Siamak Daneshmand, Jeff M Holzbeierlein, Philippe E Spiess, Eric Winquist, Simon Horenblas, Colin Dinney, Peter C Black, Wassim Kassouf
PURPOSE: Our primary endpoint was to assess pathological response rate (pT0N0 and ≤pT1N0) for patients with BCa treated with the accelerated or dose dense MVAC (ddMVAC) chemotherapy followed by radical cystectomy (RC) in this real-word multi-institutional cohort. MATERIALS AND METHODS: We retrospectively reviewed records of patients with urothelial cancer who underwent ddMVAC and RC at seven contributing institutions from 2000 to 2015. Patients with cT2-4a, M0 BCa were included...
November 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28500272/probing-the-lithium-response-pathway-in-hipscs-implicates-the-phosphoregulatory-set-point-for-a-cytoskeletal-modulator-in-bipolar-pathogenesis
#17
Brian T D Tobe, Andrew M Crain, Alicia M Winquist, Barbara Calabrese, Hiroko Makihara, Wen-Ning Zhao, Jasmin Lalonde, Haruko Nakamura, Glenn Konopaske, Michelle Sidor, Cameron D Pernia, Naoya Yamashita, Moyuka Wada, Yuuka Inoue, Fumio Nakamura, Steven D Sheridan, Ryan W Logan, Michael Brandel, Dongmei Wu, Joshua Hunsberger, Laurel Dorsett, Cordulla Duerr, Ranor C B Basa, Michael J McCarthy, Namrata D Udeshi, Philipp Mertins, Steven A Carr, Guy A Rouleau, Lina Mastrangelo, Jianxue Li, Gustavo J Gutierrez, Laurence M Brill, Nikolaos Venizelos, Guang Chen, Jeffrey S Nye, Husseini Manji, Jeffrey H Price, Colleen A McClung, Hagop S Akiskal, Martin Alda, De-Maw M Chuang, Joseph T Coyle, Yang Liu, Yang D Teng, Toshio Ohshima, Katsuhiko Mikoshiba, Richard L Sidman, Shelley Halpain, Stephen J Haggarty, Yoshio Goshima, Evan Y Snyder
The molecular pathogenesis of bipolar disorder (BPD) is poorly understood. Using human-induced pluripotent stem cells (hiPSCs) to unravel such mechanisms in polygenic diseases is generally challenging. However, hiPSCs from BPD patients responsive to lithium offered unique opportunities to discern lithium's target and hence gain molecular insight into BPD. By profiling the proteomics of BDP-hiPSC-derived neurons, we found that lithium alters the phosphorylation state of collapsin response mediator protein-2 (CRMP2)...
May 30, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28490940/systemic-therapy-in-the-curative-treatment-of-head-and-neck-squamous-cell-cancer-cancer-care-ontario-clinical-practice-guideline
#18
E Winquist, C Agbassi, B M Meyers, J Yoo, K K W Chan
OBJECTIVE: The aim of the present work was to make recommendations about the use of systemically administered drugs in combination or in sequence with radiation (rt) or surgery, or both, for cure or organ preservation, or both, in patients with locally advanced nonmetastatic (stages iii-ivb) squamous cell carcinoma of the head and neck (lascchn). METHODS: The Meta-analysis of Chemotherapy in Head and Neck Cancer (mach-nc) reports have, de facto, guided practice since 2000, and so we searched the literature for systematic reviews published from January 2000 to February 2015 in reference to five research questions...
April 2017: Current Oncology
https://www.readbyqxmd.com/read/28488581/repurposing-albendazole-new-potential-as-a-chemotherapeutic-agent-with-preferential-activity-against-hpv-negative-head-and-neck-squamous-cell-cancer
#19
Farhad Ghasemi, Morgan Black, Frederick Vizeacoumar, Nicole Pinto, Kara M Ruicci, Carson Cao Son Huu Le, Matthew R Lowerison, Hon Sing Leong, John Yoo, Kevin Fung, Danielle MacNeil, David A Palma, Eric Winquist, Joe S Mymryk, Paul C Boutros, Alessandro Datti, John W Barrett, Anthony C Nichols
Albendazole is an anti-helminthic drug that has been shown to exhibit anti-cancer properties, however its activity in head and neck squamous cell cancer (HNSCC) was unknown. Using a series of in vitro assays, we assessed the ability of albendazole to inhibit proliferation in 20 HNSCC cell lines across a range of albendazole doses (1 nM-10 μM). Cell lines that responded to treatment were further examined for cell death, inhibition of migration and cell cycle arrest. Thirteen of fourteen human papillomavirus-negative HNSCC cell lines responded to albendazole, with an average IC50 of 152 nM...
April 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28443153/supplementary-data-chemoradiotherapy-in-octogenarians-as-primary-treatment-for-muscle-invasive-bladder-cancer
#20
Victor A McPherson, George Rodrigues, Glenn Bauman, Eric Winquist, Joseph Chin, Jonathan Izawa, Kylea Potvin, Scott Ernst, Varagur Venkatesan, Tracy Sexton, Belal Ahmad, Nicholas Power
No abstract text is available yet for this article.
January 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
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