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https://www.readbyqxmd.com/read/28169118/bone-health-and-bone-targeted-therapies-for-prostate-cancer-a-programme-in-evidence-based-care-cancer-care-ontario-clinical-practice-guideline
#1
S M H Alibhai, K Zukotynski, C Walker-Dilks, U Emmenegger, A Finelli, S C Morgan, S J Hotte, E Winquist
AIMS: To make recommendations with respect to bone health and bone-targeted therapies in men with prostate cancer. MATERIALS AND METHODS: A systematic review was carried out by searching MEDLINE, EMBASE and the Cochrane Library from inception to January 2016. Systematic reviews and randomised-controlled trials were considered for inclusion if they involved therapies directed at improving bone health or outcomes such as skeletal-related events, pain and quality of life in patients with prostate cancer either with or without metastases to bone...
February 3, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28040660/quality-of-life-and-swallowing-with-standard-chemoradiotherapy-versus-accelerated-radiotherapy-and-panitumumab-in-locoregionally-advanced-carcinoma-of-the-head-and-neck-a-phase-iii-randomised-trial-from-the-canadian-cancer-trials-group-hn-6
#2
Jolie Ringash, John N Waldron, Lillian L Siu, Rosemary Martino, Eric Winquist, Jim R Wright, Abdenour Nabid, John H Hay, Alex Hammond, Khalil Sultanem, Sebastien Hotte, Carson Leong, Ali Abdel Halim El-Gayed, Farah Naz, Kevin Ramchandar, Timothy E Owen, Alexander Montenegro, Brian O'Sullivan, Bingshu E Chen, Wendy R Parulekar
AIM: To compare quality of life (QOL) between standard (SFX) chemoradiotherapy (arm A) and altered fractionation radiotherapy (AFX) with panitumumab (PMab; arm B). METHODS: Patients with T any N + M0 or T3-4N0M0 squamous cell head-neck carcinoma were randomised to SFX (70 Gy/35/7 wks) plus cisplatin (100 mg/m(2) IV × 3) versus AFX (70 Gy/35/6 wks) plus PMab (9 mg/kg IV × 3). QOL was collected at baseline, end of radiation therapy (RT) and 2, 4, 6, 12, 24 and 36 months post-RT using the Functional Assessment of Cancer Therapy Head and Neck (FACT-H&N), MD Anderson Dysphagia Index (MDADI) and SWAL-QOL...
February 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28003835/a-citizen-science-study-documents-environmental-exposures-and-asthma-prevalence-in-two-communities
#3
Samantha Eiffert, Yomi Noibi, Stephen Vesper, Jonathan Downs, Florence Fulk, Juanita Wallace, Melanie Pearson, Andrea Winquist
A citizen-science study was conducted in two low-income, flood-prone communities in Atlanta, Georgia, in order to document environmental exposures and the prevalence of occupant asthma. Teams consisting of a public-health graduate student and a resident from one of the two communities administered a questionnaire, inspected residences for mold growth, and collected a dust sample for quantifying mold contamination. The dust samples were analyzed for the 36 molds that make up the Environmental Relative Moldiness Index (ERMI)...
2016: Journal of Environmental and Public Health
https://www.readbyqxmd.com/read/27984424/estimating-acute-cardiorespiratory-effects-of-ambient-volatile-organic-compounds
#4
Dongni Ye, Mitchel Klein, Howard H Chang, Jeremy A Sarnat, James A Mulholland, Eric S Edgerton, Andrea Winquist, Paige E Tolbert, Stefanie Ebelt Sarnat
BACKGROUND: The health effects of ambient volatile organic compounds (VOCs) have received less attention in epidemiologic studies than other commonly measured ambient pollutants. In this study, we estimated acute cardiorespiratory effects of ambient VOCs in an urban population. METHODS: Daily concentrations of 89 VOCs were measured at a centrally-located ambient monitoring site in Atlanta and daily counts of emergency department visits for cardiovascular diseases and asthma in the five-county Atlanta area were obtained for the 1998-2008 period...
March 2017: Epidemiology
https://www.readbyqxmd.com/read/27930762/effect-of-standard-radiotherapy-with-cisplatin-vs-accelerated-radiotherapy-with-panitumumab-in-locoregionally-advanced-squamous-cell-head-and-neck-carcinoma-a-randomized-clinical-trial
#5
Lillian L Siu, John N Waldron, Bingshu E Chen, Eric Winquist, Jim R Wright, Abdenour Nabid, John H Hay, Jolie Ringash, Geoffrey Liu, Ana Johnson, George Shenouda, Martin Chasen, Andrew Pearce, James B Butler, Stephen Breen, Eric Xueyu Chen, T J FitzGerald, T J Childs, Alexander Montenegro, Brian O'Sullivan, Wendy R Parulekar
Importance: The Canadian Cancer Trials Group study HN.6 is the largest randomized clinical trial to date comparing the concurrent administration of anti-epidermal growth factor receptor (EGFR) monoclonal antibodies with radiotherapy (RT) to standard chemoradiotherapy in locoregionally advanced squamous cell carcinoma of the head and neck (LA-SCCHN). Objective: To compare progression-free survival (PFS) in patients with LA-SCCHN treated with standard-fractionation RT plus high-dose cisplatin vs accelerated-fractionation RT plus the anti-EGFR antibody panitumumab...
December 8, 2016: JAMA Oncology
https://www.readbyqxmd.com/read/27878048/validation-of-a-prediction-model-for-avoiding-post-chemotherapy-retroperitoneal-lymphadenectomy-in-patients-with-metastatic-nonseminomatous-germ-cell-cancer
#6
Nahid Punjani, Nicholas Power, James J Vanhie, Eric Winquist
INTRODUCTION: Post-chemotherapy residual masses (PCRMs) may contain persistent cancer or teratoma in more than 50% of patients with metastatic non-seminomatous germ cell tumours (mNSGCTs). Retroperitoneal lymph node dissection (RPLND) is curative, but controversy exists about selection criteria for surgery. A validated prediction model by Vergouwe et al (2007) based on over 1000 patients was evaluated at our centre. METHODS: mNSGCT patients treated with RPLND for PCRMs were identified from an electronic database...
August 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/27836109/characterization-of-synthesized-and-commercial-forms-of-magnesium-stearate-using-differential-scanning-calorimetry-thermogravimetric-analysis-powder-x-ray-diffraction-and-solid-state-nmr-spectroscopy
#7
Sean P Delaney, Matthew J Nethercott, Christopher J Mays, Nickolas T Winquist, Donia Arthur, Julie L Calahan, Manish Sethi, Daniel S Pardue, Junghyun Kim, Gregory Amidon, Eric J Munson
Magnesium stearate is the salt of a complex mixture of fatty acids, with the majority being stearate and palmitate. It has multiple crystalline forms and, potentially, an amorphous form. Magnesium stearate is used in the pharmaceutical manufacturing industry as a powder lubricant, and typically is added at low levels (∼1%) during the manufacturing process and blended for a relatively short time (∼5 min). Proper levels and mixing times are needed, as too short a mixing time or too small a quantity will result in improper lubrication, and too much can negatively impact dissolution rates...
January 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27727063/quality-of-life-and-performance-status-from-a-substudy-conducted-within-a-prospective-phase-3-randomized-trial-of-concurrent-standard-radiation-versus-accelerated-radiation-plus-cisplatin-for-locally-advanced-head-and-neck-carcinoma-nrg-oncology-rtog-0129
#8
Canhua Xiao, Qiang Zhang, Phuc Felix Nguyen-Tân, Marcie List, Randal S Weber, K Kian Ang, David Rosenthal, Edith J Filion, Harold Kim, Craig Silverman, Adam Raben, Thomas Galloway, Andre Fortin, Elizabeth Gore, Eric Winquist, Christopher U Jones, William Robinson, David Raben, Quynh-Thu Le, Deborah Bruner
PURPOSE/OBJECTIVE(S): To analyze quality of life (QOL) and performance status (PS) for head and neck cancer (HNC) patients treated on NRG Oncology RTOG 0129 by treatment (secondary outcome) and p16 status, and to examine the association between QOL/PS and survival. METHODS AND MATERIALS: Eligible patients were randomized into either an accelerated-fractionation arm or a standard-fractionation arm, and completed the Performance Status Scale for the Head and Neck (PSS-HN), the Head and Neck Radiotherapy Questionnaire (HNRQ), and the Spitzer Quality of Life Index (SQLI) at 8 time points from before treatment to 5 years after treatment...
July 25, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27726357/active-site-mapping-of-an-aspartic-protease-by-multiple-fragment-crystal-structures-versatile-warheads-to-address-a-catalytic-dyad
#9
Nedyalka Radeva, Johannes Schiebel, Xiaojie Wang, Stefan G Krimmer, Kan Fu, Martin Stieler, Frederik R Ehrmann, Alexander Metz, Thomas Rickmeyer, Michael Betz, Johan Winquist, Ah Young Park, Franziska U Huschmann, Manfred S Weiss, Uwe Mueller, Andreas Heine, Gerhard Klebe
Crystallography is frequently used as follow-up method to validate hits identified by biophysical screening cascades. The capacity of crystallography to directly screen fragment libraries is often underestimated, due to its supposed low-throughput and need for high-quality crystals. We applied crystallographic fragment screening to map the protein-binding site of the aspartic protease endothiapepsin by individual soaking experiments. Here, we report on 41 fragments binding to the catalytic dyad and adjacent specificity pockets...
November 10, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27706089/susceptibility-to-heat-related-fluid-and-electrolyte-imbalance-emergency-department-visits-in-atlanta-georgia-usa
#10
Leila Heidari, Andrea Winquist, Mitchel Klein, Cassandra O'Lenick, Andrew Grundstein, Stefanie Ebelt Sarnat
Identification of populations susceptible to heat effects is critical for targeted prevention and more accurate risk assessment. Fluid and electrolyte imbalance (FEI) may provide an objective indicator of heat morbidity. Data on daily ambient temperature and FEI emergency department (ED) visits were collected in Atlanta, Georgia, USA during 1993-2012. Associations of warm-season same-day temperatures and FEI ED visits were estimated using Poisson generalized linear models. Analyses explored associations between FEI ED visits and various temperature metrics (maximum, minimum, average, and diurnal change in ambient temperature, apparent temperature, and heat index) modeled using linear, quadratic, and cubic terms to allow for non-linear associations...
October 2, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27569059/quantitative-analysis-of-human-pluripotency-and-neural-specification-by-in-depth-phospho-proteomic-profiling
#11
Ilyas Singec, Andrew M Crain, Junjie Hou, Brian T D Tobe, Maria Talantova, Alicia A Winquist, Kutbuddin S Doctor, Jennifer Choy, Xiayu Huang, Esther La Monaca, David M Horn, Dieter A Wolf, Stuart A Lipton, Gustavo J Gutierrez, Laurence M Brill, Evan Y Snyder
Controlled differentiation of human embryonic stem cells (hESCs) can be utilized for precise analysis of cell type identities during early development. We established a highly efficient neural induction strategy and an improved analytical platform, and determined proteomic and phosphoproteomic profiles of hESCs and their specified multipotent neural stem cell derivatives (hNSCs). This quantitative dataset (nearly 13,000 proteins and 60,000 phosphorylation sites) provides unique molecular insights into pluripotency and neural lineage entry...
September 13, 2016: Stem Cell Reports
https://www.readbyqxmd.com/read/27565809/sunitinib-maintenance-therapy-after-response-to-docetaxel-in-metastatic-castration-resistant-prostate-cancer-mcrpc
#12
Sunil Parimi, Misha Eliasziw, Scott North, Marc Trudeau, Eric Winquist, Kim N Chi, Dean Ruether, Tina Cheng, Bernhard J Eigl
Background Docetaxel is a standard first-line treatment option for men with metastatic castration resistant prostate cancer (mCRPC). Sunitinib is attractive as a maintenance therapy due to its mechanism of action, oral route of administration, and acceptable toxicity profile. We designed a phase II study of sunitinib in patients with mCRPC who responded to docetaxel. Methods Patients with responding or stable disease at the completion of docetaxel treatment received 50 mg of sunitinib on 4 week on 2 week off cycles...
August 26, 2016: Investigational New Drugs
https://www.readbyqxmd.com/read/27529882/a-study-of-reverse-causation-examining-the-associations-of-perfluorooctanoic-acid-serum-levels-with-two-outcomes
#13
Radhika Dhingra, Andrea Winquist, Lyndsey A Darrow, Mitchel Klein, Kyle Steenland
BACKGROUND: Impaired kidney function and earlier menopause were associated with perfluorooctanoic acid (PFOA) serum levels in prior cross-sectional studies. Reverse causation, whereby health outcomes increase serum PFOA, may underlie these associations. OBJECTIVE: We compared measured (subject to reverse causation) vs. modeled (unaffected by reverse causation) serum PFOA in association with these outcomes, to examine the possible role of reverse causation in these associations...
August 16, 2016: Environmental Health Perspectives
https://www.readbyqxmd.com/read/27474080/pretreatment-serum-folate-levels-and-toxicity-efficacy-in-colorectal-cancer-patients-treated-with-5-fluorouracil-and-folinic-acid
#14
Michael Yan, Cheryl Ho, Eric Winquist, Derek Jonker, Daniel Rayson, Larry Stitt, Sonya Tokmakejian, Anna Tomiak, Mark D Vincent
BACKGROUND: 5-Fluorouracil (5-FU) chemotherapy is associated with severe and unpredictable toxicity in a significant proportion of patients. 5,10-Methylenetetrahydrofolate and 5-fluorodeoxyuridine monophosphate bind to thymidylate synthase and together inhibit its function, resulting in cytotoxicity. We hypothesized that susceptibility to 5-FU toxicity might be related to individual differences in the serum components of folate metabolism affecting intracellular 5,10-methylenetetrahydrofolate levels...
December 2016: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/27422981/assessment-of-neighbourhood-level-socioeconomic-status-as-a-modifier-of-air-pollution-asthma-associations-among-children-in-atlanta
#15
Cassandra R O'Lenick, Andrea Winquist, James A Mulholland, Mariel D Friberg, Howard H Chang, Michael R Kramer, Lyndsey A Darrow, Stefanie Ebelt Sarnat
BACKGROUND: A broad literature base provides evidence of association between air pollution and paediatric asthma. Socioeconomic status (SES) may modify these associations; however, previous studies have found inconsistent evidence regarding the role of SES. METHODS: Effect modification of air pollution-paediatric asthma morbidity by multiple indicators of neighbourhood SES was examined in Atlanta, Georgia. Emergency department (ED) visit data were obtained for 5-18 years old with a diagnosis of asthma in 20-county Atlanta during 2002-2008...
July 15, 2016: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/27389561/prenatal-screening-diagnosis-and-termination-of-pregnancy-in-first-nations-and-rural-women
#16
Brandace Winquist, Nazeem Muhajarine, Keith Ogle, Debbie Mpofu, Denis Lehotay, Gary Teare
OBJECTIVES: The objectives of the study were to assess differences in utilization of maternal serum screening (MSS) and prenatal diagnostic testing between population subgroups and to determine the impact on chromosomal anomaly birth rates. METHODS: This population-based cohort study included all female residents from Saskatchewan, Canada, who delivered a baby, experienced a fetal loss, or had a pregnancy termination between 2000 and 2005. In total, 93 171 women were included in the study dataset, with a subset (n = 35 527) evaluated to identify predictors of screening and diagnostic testing...
September 2016: Prenatal Diagnosis
https://www.readbyqxmd.com/read/27315241/associations-between-source-specific-fine-particulate-matter-and-emergency-department-visits-for-respiratory-disease-in-four-u-s-cities
#17
Jenna R Krall, James A Mulholland, Armistead G Russell, Sivaraman Balachandran, Andrea Winquist, Paige E Tolbert, Lance A Waller, Stefanie Ebelt Sarnat
BACKGROUND: Short-term exposure to ambient fine particulate matter (PM2.5) concentrations has been associated with increased mortality and morbidity. Determining which sources of PM2.5 are most toxic can help guide targeted reduction of PM2.5. However, conducting multicity epidemiologic studies of sources is difficult because source-specific PM2.5 is not directly measured, and source chemical compositions can vary between cities. OBJECTIVES: We determined how the chemical composition of primary ambient PM2...
January 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/27217856/efficacy-quality-of-life-and-safety-of-cabazitaxel-in-canadian-metastatic-castration-resistant-prostate-cancer-patients-treated-or-not-with-prior-abiraterone
#18
Fred Saad, Eric Winquist, Stacey Hubay, Scott Berry, Hazem Assi, Eric Levesque, Nathalie Aucoin, Piotr Czaykowski, Jean-Baptiste Lattouf, Karine Alloul, John Stewart, Srikala S Sridhar
INTRODUCTION: In the TROPIC study, cabazitaxel improved overall survival in abiraterone-naïve metastatic castration-resistant prostate cancer (mCRPC) patients post-docetaxel. To evaluate cabazitaxel in routine clinical practice, an international, single-arm trial was conducted. Efficacy, safety, and quality of life (QoL) data were collected from Canadian patients enrolled. Overall survival and progression-free survival were not collected as part of this study. Importantly, prior abiraterone use was obtained and its impact on clinical parameters was examined...
March 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/27180362/outcome-of-titanium-elastic-intramedullary-nail-in-the-treatment-of-shaft-of-femur-fracture-in-children
#19
J A Khan, G P Singh, A Pandey
Background Femoral-shaft fractures are among the most common fractures of the lower extremity in children. There are several different options for treating femoral-shaft fractures in children. Elastic stable intramedullary nailing (ESIN) has become the standard treatment for fractures of shaft of femur in children for reasons including mini-invasive surgery, no need for casting, early mobilization and discharge as well as growing concerns toward cost-effectiveness. Objective To demonstrate the effectiveness of intramedullary fixation of fracture shaft of femur in skeletally immature children using the titanium elastic intramedullary nails...
July 2015: Kathmandu University Medical Journal (KUMJ)
https://www.readbyqxmd.com/read/27114489/occurrence-of-pregnancy-and-pregnancy-outcomes-during-isotretinoin-therapy
#20
David Henry, Colin Dormuth, Brandace Winquist, Greg Carney, Shawn Bugden, Gary Teare, Linda E Lévesque, Anick Bérard, J Michael Paterson, Robert W Platt
BACKGROUND: Isotretinoin, a teratogen, is widely used to treat cystic acne. Although the risks of pregnancy during isotretinoin therapy are well recognized, there are doubts about the level of adherence with the pregnancy prevention program in Canada. Our objective was to evaluate the effectiveness of the Canadian pregnancy prevention program in 4 provinces: British Columbia, Saskatchewan, Manitoba and Ontario. METHODS: Using administrative data, we identified 4 historical cohorts of female users of isotretinoin (aged 12-48 yr) for the period 1996 to 2011...
July 12, 2016: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
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