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https://www.readbyqxmd.com/read/29774304/arrhythmogenic-right-ventricular-cardiomyopathy-in-boxer-dogs-the-diagnosis-as-a-link-to-the-human-disease
#1
Annina S Vischer, David J Connolly, Caroline J Coats, Virginia Luis Fuentes, William J McKenna, Silvia Castelletti, Antonios A Pantazis
Background: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a myocardial disease with an increased risk for ventricular arrhythmias. The condition, which occurs in Boxer dogs, shares phenotypic features with the human disease arrhythmogenic cardiomyopathy (ACM) suggesting its potential as a natural animal model. However, there are currently no universally accepted clinical criteria to diagnose ARVC in Boxer dogs. We aimed to identify diagnostic criteria for ARVC in Boxer dogs defining a more uniform and consistent phenotype...
September 2017: Acta Myologica: Myopathies and Cardiomyopathies: Official Journal of the Mediterranean Society of Myology
https://www.readbyqxmd.com/read/29765858/neural-stem-cell-activation-and-the-role-of-protein-synthesis
#2
REVIEW
Avni Baser, Maxim Skabkin, Ana Martin-Villalba
Adult neural stem cells are generated at embryonic stages by entering a quiescent state that allows their retention into adulthood and thereby maintenance of life-long brain homeostasis. Thus, a tight balance between the quiescence and activation state is instrumental to meet the brain demands for a specific cell type at the correct numbers, at a given time and position. Protein synthesis is the most energy-consuming process within the cell and, not surprisingly, it occurs at low rates in quiescent stem cells...
November 9, 2017: Brain Plasticity
https://www.readbyqxmd.com/read/29759837/clinical-features-and-sites-of-ablation-for-patients-with-incessant-supraventricular-tachycardia-from-concealed-nodofascicular-and-nodoventricular-tachycardias
#3
Frederick T Han, Eric M Riles, Nitish Badhwar, Melvin M Scheinman
OBJECTIVES: This study sought to describe the clinical features and sites of successful ablation for incessant nodofascicular (NF) and nodoventricular (NV) tachycardias. BACKGROUND: Incessant supraventricular tachycardias have been associated with tachycardia-induced cardiomyopathies and have been previously attributed to permanent junctional reciprocating tachycardias, atrial tachycardias, and atrioventricular nodal re-entrant tachycardias. Incessant concealed NF and NV tachycardias have not been described previously...
December 26, 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29759626/post-extrasystolic-potentiation-for-individualizing-care-of-premature-ventricular-contraction-induced-cardiomyopathy
#4
EDITORIAL
Siva K Mulpuru, Chance M Witt
No abstract text is available yet for this article.
November 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29759625/post-extrasystolic-potentiation-as-a-predictor-of-recovery-of-left-ventricular-dysfunction-after-radiofrequency-catheter-ablation
#5
Balaji Krishnan, Ashwini Sankar, Inder Anand, Selcuk Adabag, Jian-Ming Li, Edward O McFalls, David G Benditt, Kalyanam Shivkumar, Venkatakrishna N Tholakanahalli
OBJECTIVES: This study hypothesizes that post-extrasystolic potentiation reflects left ventricle contractile reserve and therefore may predict an improvement of premature ventricular contraction (PVC)-induced cardiomyopathy after PVC ablation. BACKGROUND: Post-extrasystolic potentiation is a physiologic phenomenon of blood pressure accentuation after a PVC beat. METHODS: We performed a retrospective study of patients with a PVC burden of ≥10% PVC/24 h and left ventricular ejection fraction (LVEF) of <50% who underwent successful ablation between January 1, 2009, to June 30, 2015...
November 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29759621/analyses-of-the-mode-of-termination-during-diagnostic-ventricular-pacing-to-differentiate-the-mechanisms-of-supraventricular-tachycardias
#6
Mitsunori Maruyama, Shunsuke Uetake, Yasushi Miyauchi, Yoshihiko Seino, Wataru Shimizu
OBJECTIVES: The goal of this study was to determine the diagnostic yield of analyzing the mode of termination during ventricular overdrive pacing (VOP) to differentiate the mechanisms of supraventricular tachycardias (SVTs). BACKGROUND: The majority of the diagnostic criteria for VOP rely on successful entrainment, but termination of SVTs is common during VOP. METHODS: We studied 225 SVTs with a 1:1 atrioventricular relationship, including 34 atrial tachycardias, 67 orthodromic reciprocating tachycardias (ORTs) (including 4 ORTs using accessory pathways [APs] with decremental properties), and 124 atrioventricular nodal re-entrant tachycardias...
November 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29759541/the-phenotypic-spectrum-of-a-mutation-hotspot-responsible-for-the-short-qt-syndrome
#7
Dan Hu, Yang Li, Jiancheng Zhang, Ryan Pfeiffer, Michael H Gollob, Jeff Healey, Daniel Toshio Harrell, Naomasa Makita, Haruhiko Abe, Yaxun Sun, Jihong Guo, Li Zhang, Ganxin Yan, Douglas Mah, Edward P Walsh, Harris B Leopold, Carla Giustetto, Fiorenzo Gaita, Agnieszka Zienciuk-Krajka, Andrea Mazzanti, Silvia G Priori, Charles Antzelevitch, Hector Barajas-Martinez
OBJECTIVES: This study sought to evaluate the phenotypic and functional expression of an apparent hotspot mutation associated with short QT syndrome (SQTS). BACKGROUND: SQTS is a rare channelopathy associated with a high risk of life-threatening arrhythmias and sudden cardiac death (SCD). METHODS: Probands diagnosed with SQTS and their family members were evaluated clinically and genetically. KCNH2 wild-type (WT) and mutant genes were transiently expressed in HEK293 cells, and currents were recorded using whole-cell patch clamp and action potential (AP) clamp techniques...
July 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29759536/value-of-a-posterior-electrocardiographic-lead-for-localization-of-ventricular-outflow-tract-arrhythmias-the-v-4-v-8-ratio
#8
Fengxiang Zhang, David Hamon, Zhen Fang, Yan Xu, Bing Yang, Weizhu Ju, Jason Bradfield, Kalyanam Shivkumar, Minglong Chen, Roderick Tung
OBJECTIVES: This study sought to prospectively evaluate the value of a dedicated electrocardiographic posterior lead to create an anteroposterior ratio to localize premature ventricular complexes (PVCs) between the right ventricular outflow tract and left ventricular outflow tract for catheter ablation. BACKGROUND: The anteroposterior relationship between the right and left outflow tract has not been explored for electrocardiographic localization of ventricular arrhythmia...
July 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29759092/cardiac-function-in-children-with-premature-ventricular-contractions-the-effect-of-omega-3-polyunsaturated-fatty-acid-supplementation
#9
Taliha Oner, Rahmi Ozdemir, Onder Doksöz, Dildar B Genc, Baris Guven, Savas Demirpence, Murat M Yilmazer, Yilmaz Yozgat, Timur Mese, Vedide Tavli
BACKGROUND: Premature ventricular contractions are accepted as benign in structurally normal hearts. However, reversible cardiomyopathy can sometimes develop. Omega-3 polyunsaturated fatty acids have anti-arrhythmic properties in animals and humans.AimWe evaluated left ventricular function in children with premature ventricular contractions with normal cardiac anatomy and assessed the impact of omega-3 fatty acid supplementation on left ventricular function in a prospective trial. METHODS: A total of 25 patients with premature ventricular contraction, with more than 2% premature ventricular contractions on 24-hour Holter electrocardiography, and 30 healthy patients were included into study...
May 15, 2018: Cardiology in the Young
https://www.readbyqxmd.com/read/29756643/isolated-premature-restriction-or-closure-of-foramen-ovale-in-fetuses-echocardiographic-characteristics-and-outcome
#10
Xiaoyan Gu, Ye Zhang, Jiancheng Han, Xiaowei Liu, Shuping Ge, Yihua He
BACKGROUND: Premature restriction or closure of foramen ovale (FO) in otherwise structurally normal hearts may be associated with right ventricular dilation, tricuspid regurgitation, pericardial effusion, heart failure, even poor perinatal outcomes. Data about these rare conditions are lacking. METHODS: We retrospectively reviewed the echocardiographic records of 9704 fetuses seen from 2010 to 2014 in Beijing Anzhen Hospital, a regional and national referral center, to ascertain the presence of restriction or closure of FO...
May 14, 2018: Echocardiography
https://www.readbyqxmd.com/read/29749652/evolution-of-echocardiography-in-subclinical-detection-of-cancer-therapy-related-cardiac-dysfunction
#11
REVIEW
Rohit Moudgil, Saamir Hassan, Nicolas Palaskas, Juan Lopez-Mattei, Jose Banchs, Syed Wamique Yusuf
Cancer therapies have resulted in increased survivorship in oncological patients. However, the benefits have been marred by the development of premature cardiovascular disease. The current definition outlines measurement of ejection fraction as a mean to diagnose cancer therapeutic-related cardiac dysfunction (CTRCD); however, up to 58% of the patients do not regain their cardiac function after the CTRCD diagnosis, despite therapeutic interventions. Therefore, there has been a growing interest in the markers for early myocardial changes (ie, changes with normal left ventricular ejection fraction [LVEF]) that may predict the development of subsequent left ventricular ejection fraction reduction or progression to heart failure...
May 11, 2018: Echocardiography
https://www.readbyqxmd.com/read/29746007/preterm-growth-restriction-and-bronchopulmonary-dysplasia-the-vascular-hypothesis-and-related-physiology
#12
Arvind Sehgal, Stella M Gwini, Samuel Menahem, Beth J Allison, Suzanne L Miller, Graeme R Polglase
KEY POINTS: Approximately 5-10% pregnancies are affected by fetal growth restriction. Preterm infants affected by fetal growth restriction have a higher incidence of bronchopulmonary dysplasia. This study is the first to measure pulmonary artery thickness and stiffness. It highlights that impaired vasculogenesis may be a contributory factor in the higher incidence of bronchopulmonary dysplasia in preterm growth restricted infants. The study addresses the mechanistic link between fetal programming and vascular architecture and mechanics...
May 10, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29745607/-characteristics-of-the-inferior-wall-hypertrophy-in-hypertrophic-cardiomyopathy-patients-with-contrast-echocardiography
#13
Zhiyue Liu, Wen Zhang, Xianchao Jing, Lei Xiao, He Huang
We tried to explore the value of contrast echocardiography (CEcho) on evaluating hypertrophic cardiomyopathy (HCM) with the inferior wall hypertrophy. A total of 114 patients with HCM were investigated. All the patients received CEcho and routine echocardiography (Echo), and 45 of them received cardiac magnetic resonance (CMR) and 47 of them received Holter. The frequency and percentage of inferior wall hypertrophy were analyzed in HCM patients, as well as the structure and function. The results showed that: (1) Inferior wall hypertrophy was detected in 55 patients (48%) by Echo, while 68 patients (60%) by CEcho...
February 1, 2018: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29745596/-extraction-and-recognition-of-attractors-in-three-dimensional-lorenz-plot
#14
Min Hu, Chengfan Jang, Suxia Wang
Lorenz plot (LP) method which gives a global view of long-time electrocardiogram signals, is an efficient simple visualization tool to analyze cardiac arrhythmias, and the morphologies and positions of the extracted attractors may reveal the underlying mechanisms of the onset and termination of arrhythmias. But automatic diagnosis is still impossible because it is lack of the method of extracting attractors by now. We presented here a methodology of attractor extraction and recognition based upon homogeneously statistical properties of the location parameters of scatter points in three dimensional LP (3DLP), which was constructed by three successive RR intervals as X , Y and Z axis in Cartesian coordinate system...
February 1, 2018: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29744061/ablation-of-parahisian-premature-ventricular-extrasystoles-by-subtricuspid-retrograde-approach-using-inverted-catheter-technique-back-to-the-anatomy
#15
Basar Candemir, Veysel Duzen, Firat Coskun, Veysel Kutay Vurgun, Huseyin Goksuluk, Nil Ozyuncu, Seda Tan Kurklu, Ali Timucin Altin, Omer Akyurek, Cetin Erol
This report illustrates a feasible and anatomical solution aiming to improve the success and decrease the possible hazards such as atrioventricular block during ablation of parahisian PVCs. We tried to illustrate the specific anatomy pertaining parahisian region and to explain a retrograde subvalvular catheter technique to overcome these procedural obstacles.
May 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29740701/characteristics-and-circadian-distribution-of-cardiac-arrhythmias-in-patients-with-heart-failure-and-sleep-disordered-breathing
#16
Hazem Omran, Thomas Bitter, Dieter Horstkotte, Olaf Oldenburg, Henrik Fox
BACKGROUND: Cardiac arrhythmias and sleep-disordered breathing (SDB) are common comorbidities in heart failure with reduced ejection fraction (HFrEF). However, understanding of the association between arrhythmias and SDB is poor. This study assessed the occurrence and circadian distribution of ventricular arrhythmias in HFrEF patients with and without SDB. METHODS: This retrospective analysis included HFrEF patients admitted for unattended overnight cardiorespiratory polygraphy and 24-h Holter-ECG recording...
May 8, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29738372/paradoxical-effects-of-sodium-calcium-exchanger-inhibition-on-torsade-de-pointes-and-early-afterdepolarization-in-a-heart-failure-rabbit-model
#17
Po-Cheng Chang, Yu-Ying Lu, Hui-Ling Lee, Shien-Fong Lin, Yen Chu, Ming-Shien Wen, Chung-Chuan Chou
Calcium homeostasis plays an important role in development of early afterdepolarizations (EADs) and torsade de pointes (TdP). The role of sodium-calcium exchanger (NCX) inhibition in genesis secondary Ca rise and EADs-TdP is still debated. Dual voltage and intracellular Ca optical mapping were conducted in 6 control and 9 failing rabbit hearts. After baseline electrophysiological and optical mapping studies, E4031 was given to simulate long QT syndrome. ORM-10103 was then administrated to examine the electrophysiological effects on EAD-TdP development...
May 3, 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29737447/predicting-value-of-coupling-interval-variability-in-determining-the-origin-of-ventricular-premature-contractions-with-v3-transition
#18
Umut Celikyurt, Aysen Agir, Irem Karauzum, Kurtulus Karauzum, Tayfun Sahin, Ahmet Vural
PURPOSE: We aimed to investigate the predictive value of coupling interval variability (ΔCI) in determining the origin of idiopathic outflow tract ventricular tachycardia (OTVT) with V3 transition. METHODS: We reviewed data from 126 patients who underwent catheter ablation of OTVT between 2015 and 2018 at our institution. We identified 32 patients of successful OTVT ablation with a precordial transition at V3 derivation. The ΔCI (maximum - minimum CI) was measured...
May 8, 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/29736793/a-novel-imaging-finding-in-williams-syndrome-the-coral-sign
#19
Jeremy R Burt, Kimberly Beavers, Melissa Kendall, Michael Valente, Jorge A Garcia
A 16-year-old female, with a history of Williams syndrome, presented to our institution with a 2-week history of intermittent dizziness. Holter monitoring demonstrated occasional premature ventricular contractions with rare couplets and triplets as well as one short run of nonsustained ventricular tachycardia. Echocardiography revealed an abnormal and irregular left ventricular septum with multiple mobile, pedunculated muscular projections extending into the left ventricular cavity. Cardiac MR confirmed abnormally thickened trabeculations consisting of multiple parallel ridges of myocardium crossing the left ventricle...
May 7, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29731502/idiopathic-ventricular-premature-contraction-and-ventricular-tachycardia-distribution-of-the-origin-diagnostic-algorithm-and-catheter-ablation
#20
Yoshinori Kobayashi
Idiopathic ventricular premature contractions (VPCs), defined as VPCs in the absence of obvious structural heart disease, are one of the common types of arrhythmia in clinical practice. They are sometimes complicated with non-sustained ventricular tachycardia (VT), and/or sustained VT with almost same QRS morphology in 12 leads ECG. Idiopathic VT (IVT) commonly occurs by focal mechanisms and the origins are distributed in a variety of sites in both ventricles. In this article, the clinical characteristics of IVT/IVPCs, the diagnostic algorithm, and how to ablate them will be reviewed...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
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