keyword
https://read.qxmd.com/read/38528269/white-matter-associations-with-spelling-performance
#1
JOURNAL ARTICLE
Romi Sagi, J S H Taylor, Kyriaki Neophytou, Tamar Cohen, Brenda Rapp, Kathleen Rastle, Michal Ben-Shachar
Multiple neurocognitive processes are involved in the highly complex task of producing written words. Yet, little is known about the neural pathways that support spelling in healthy adults. We assessed the associations between performance on a difficult spelling-to-dictation task and microstructural properties of language-related white matter pathways, in a sample of 73 native English-speaking neurotypical adults. Participants completed a diffusion magnetic resonance imaging scan and a cognitive assessment battery...
March 25, 2024: Brain Structure & Function
https://read.qxmd.com/read/38477600/time-matters-cervical-ripening-balloon-for-6-versus-12%C3%A2-h-retrospective-comparison-between-two-protocols
#2
JOURNAL ARTICLE
Inna Bleicher, Michal Korobochka, Shlomi Sagi, Rami Sammour
OBJECTIVE: Recently, two randomized controlled trials compared removal of cervical ripening balloon (CRB) after 6 versus 12 h. Their results showed similar Bishop score changes in both groups and a shorter time to delivery in the 6-h group. Neither of the studies was powered to show difference in mode of delivery. The aim of this study was to compare mode of delivery when the CRB was removed after 6 versus 12 h. METHODS: A historical control study comparing induction of labor with a CRB between two time periods, one in which the CRB was removed after 12 h (12-h group), and the other in which it was removed after 6 h (6-h group)...
March 13, 2024: International Journal of Gynaecology and Obstetrics
https://read.qxmd.com/read/38363592/fetal-intraventricular-hemorrhage-and-periventricular-hemorrhagic-venous-infarction-time-for-dedicated-classification-system
#3
JOURNAL ARTICLE
E Hadi, L Haddad, M Levy, L Gindes, M Hausman-Kedem, H Bassan, L Ben-Sira, S Libzon, E Kassif, C Hoffmann, Z Leibovitz, G Kasprian, T Lerman-Sagie
No abstract text is available yet for this article.
February 16, 2024: Ultrasound in Obstetrics & Gynecology
https://read.qxmd.com/read/38359860/the-easl-lancet-commission-on-liver-health-in-europe-prevention-case-finding-and-early-diagnosis-to-reduce-liver-related-mortality
#4
JOURNAL ARTICLE
Tom H Karlsen, Harry Rutter, Patrizia Carrieri, Shira Zelber-Sagi, Eivind Engebretsen, Sharon Hutchinson, Kristin Voigt, Neil Guha, Annalisa Berzigotti, Georg Schomerus, Pere Gines, Maria Buti, Patrizia Burra, Michael P Manns, Aleksander Krag, Sabine Kleinert
No abstract text is available yet for this article.
February 12, 2024: Lancet
https://read.qxmd.com/read/38315102/the-future-of-international-classification-of-diseases-coding-in-steatotic-liver-disease-an-expert-panel-delphi-consensus-statement
#5
JOURNAL ARTICLE
Hannes Hagström, Leon A Adams, Alina M Allen, Christopher D Byrne, Yoosoo Chang, Ajay Duseja, Henning Grønbæk, Mona H Ismail, Peter Jepsen, Fasiha Kanwal, Jennifer Kramer, Rohit Loomba, Henry E Mark, Philip N Newsome, Mary E Rinella, Ian A Rowe, Seungho Ryu, Arun Sanyal, Jörn M Schattenberg, Marina Serper, Nick Sheron, Tracey G Simon, C Wendy Spearman, Elliot B Tapper, Marcela Villota-Rivas, Sarah H Wild, Vincent Wai-Sun Wong, Yusuf Yilmaz, Shira Zelber-Sagi, Fredrik Åberg, Jeffrey V Lazarus
BACKGROUND: Following the adoption of new nomenclature for steatotic liver disease, we aimed to build consensus on the use of International Classification of Diseases codes and recommendations for future research and advocacy. METHODS: Through a two-stage Delphi process, a core group (n = 20) reviewed draft statements and recommendations (n = 6), indicating levels of agreement. Following revisions, this process was repeated with a large expert panel (n = 243) from 73 countries...
February 1, 2024: Hepatology Communications
https://read.qxmd.com/read/38299380/living-arrangements-and-housing-affordability-issues-of-young-adults-in-canada-differences-by-nativity-status
#6
JOURNAL ARTICLE
Kate H Choi, Sagi Ramaj
Housing prices in Canada have increased dramatically, giving rise to a housing affordability crisis. Young adults have been disproportionately affected by this crisis. To cope, many young adults have had to alter their living arrangements, contributing to the diversification of their living arrangements. Young adults' diverse living arrangements are the product of growing inequalities in young adults' economic prospects and access to family support. Extant work has yet to document how young adults' risk of having unaffordable housing varies according to their living arrangements...
February 1, 2024: Canadian Review of Sociology
https://read.qxmd.com/read/38279360/genetic-analysis-of-partially-resistant-and-susceptible-chickpea-cultivars-in-response-to-ascochyta-rabiei-infection
#7
JOURNAL ARTICLE
Amit A Deokar, Mandeep Sagi, Bunyamin Tar'an
The molecular mechanism involved in chickpea ( Cicer arietinum L.) resistance to the necrotrophic fungal pathogen Ascochyta rabiei is not well documented. A. rabiei infection can cause severe damage in chickpea, resulting in significant economic losses. Understanding the resistance mechanism against ascochyta blight can help to define strategies to develop resistant cultivars. In this study, differentially expressed genes from two partially resistant cultivars (CDC Corinne and CDC Luna) and a susceptible cultivar (ICCV 96029) to ascochyta blight were identified in the early stages (24, 48 and 72 h) of A...
January 22, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38190552/tranexamic-acid-and-holding-venous-thromboembolism-prophylaxis-morning-of-surgery-do-not-decrease-transfusion-requirements-in-patients-undergoing-anterior-intrapelvic-approach-for-acetabular-open-reduction-and-internal-fixation
#8
MULTICENTER STUDY
Brian H Mullis, Joshua H S Chang, Nihar Shah, Ramsey S Sabbagh, Michael T Archdeacon, Henry Claude Sagi, Roman M Natoli
INTRODUCTION: The objective of this study was to determine factors that may affect transfusion rates for patients requiring an anterior intrapelvic (AIP) approach for an acetabulum fracture. METHODS: This was a multicenter retrospective comparison study (3 trauma centers at two urban academic centers). Patients who had an AIP approach for an acetabulum fracture without other notable same-day procedures (irrigation and débridement and/or external fixation were only other allowed procedures) were included...
April 1, 2024: Journal of the American Academy of Orthopaedic Surgeons
https://read.qxmd.com/read/37964426/detailed-analysis-of-itpr1-missense-variants-guides-diagnostics-and-therapeutic-design
#9
JOURNAL ARTICLE
Jussi Pekka Tolonen, Ricardo Parolin Schnekenberg, Simon McGowan, David Sims, Meriel McEntagart, Frances Elmslie, Debbie Shears, Helen Stewart, George K Tofaris, Tabib Dabir, Patrick J Morrison, Diana Johnson, Marios Hadjivassiliou, Sian Ellard, Charles Shaw-Smith, Anna Znaczko, Abhijit Dixit, Mohnish Suri, Ajoy Sarkar, Rachel E Harrison, Gabriela Jones, Henry Houlden, Giorgia Ceravolo, Joanna Jarvis, Jonathan Williams, Morag E Shanks, Penny Clouston, Julia Rankin, Lubov Blumkin, Tally Lerman-Sagie, Penina Ponger, Salmo Raskin, Katariina Granath, Johanna Uusimaa, Hector Conti, Emma McCann, Shelagh Joss, Alexander J M Blakes, Kay Metcalfe, Helen Kingston, Marta Bertoli, Rachel Kneen, Sally Ann Lynch, Inmaculada Martínez Albaladejo, Austen Peter Moore, Wendy D Jones, Esther B E Becker, Andrea H Németh
BACKGROUND: The ITPR1 gene encodes the inositol 1,4,5-trisphosphate (IP3 ) receptor type 1 (IP3 R1), a critical player in cerebellar intracellular calcium signaling. Pathogenic missense variants in ITPR1 cause congenital spinocerebellar ataxia type 29 (SCA29), Gillespie syndrome (GLSP), and severe pontine/cerebellar hypoplasia. The pathophysiological basis of the different phenotypes is poorly understood. OBJECTIVES: We aimed to identify novel SCA29 and GLSP cases to define core phenotypes, describe the spectrum of missense variation across ITPR1, standardize the ITPR1 variant nomenclature, and investigate disease progression in relation to cerebellar atrophy...
January 2024: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/37961223/breast-cancer-macrophage-heterogeneity-and-self-renewal-are-determined-by-spatial-localization
#10
Nir Ben-Chetrit, Xiang Niu, Jesus Sotelo, Ariel D Swett, Vinagolu K Rajasekhar, Maria S Jiao, Caitlin M Stewart, Priya Bhardwaj, Sanjay Kottapalli, Saravanan Ganesan, Pierre-Louis Loyher, Catherine Potenski, Assaf Hannuna, Kristy A Brown, Neil M Iyengar, Dilip D Giri, Scott W Lowe, John H Healey, Frederic Geissmann, Irit Sagi, Johanna A Joyce, Dan A Landau
Tumor-infiltrating macrophages support critical steps in tumor progression, and their accumulation in the tumor microenvironment (TME) is associated with adverse outcomes and therapeutic resistance across human cancers. In the TME, macrophages adopt diverse phenotypic alterations, giving rise to heterogeneous immune activation states and induction of cell cycle. While the transcriptional profiles of these activation states are well-annotated across human cancers, the underlying signals that regulate macrophage heterogeneity and accumulation remain incompletely understood...
October 27, 2023: bioRxiv
https://read.qxmd.com/read/37636109/iron-uptake-of-etioplasts-is-independent-from-photosynthesis-but-applies-the-reduction-based-strategy
#11
JOURNAL ARTICLE
Máté Sági-Kazár, Éva Sárvári, Barnabás Cseh, Levente Illés, Zoltán May, Csaba Hegedűs, Attila Barócsi, Sándor Lenk, Katalin Solymosi, Ádám Solti
INTRODUCTION: Iron (Fe) is one of themost important cofactors in the photosynthetic apparatus, and its uptake by chloroplasts has also been associated with the operation of the photosynthetic electron transport chain during reduction-based plastidial Fe uptake. Therefore, plastidial Fe uptake was considered not to be operational in the absence of the photosynthetic activity. Nevertheless, Fe is also required for enzymatic functions unrelated to photosynthesis, highlighting the importance of Fe acquisition by non-photosynthetic plastids...
2023: Frontiers in Plant Science
https://read.qxmd.com/read/37601814/corrigendum-to-relative-frequency-of-avascular-necrosis-of-the-hip-as-indication-for-primary-total-hip-arthroplasty-in-the-usa-vs-india-j-orthop-36c-2023-1-6
#12
Ramakanth R Yakkanti, Sagie Haziza, Nathan A Wasserman, Adarsh Annapareddy, V Ratnakar, S R Karri, Victor H Hernandez, A V Gurava Reddy, Raju Vaishya
[This corrects the article DOI: 10.1016/j.jor.2022.12.002.].
August 2023: Journal of Orthopaedics
https://read.qxmd.com/read/37587020/accurate-prediction-of-antimicrobial-susceptibility-for-point-of-care-testing-of-urine-in-less-than-90-minutes-via-iprism-cassettes
#13
JOURNAL ARTICLE
Xin Jiang, Talya Borkum, Sagi Shprits, Joseph Boen, Sofia Arshavsky-Graham, Baruch Rofman, Merav Strauss, Raul Colodner, Jeremias Sulam, Sarel Halachmi, Heidi Leonard, Ester Segal
The extensive and improper use of antibiotics has led to a dramatic increase in the frequency of antibiotic resistance among human pathogens, complicating infectious disease treatments. In this work, a method for rapid antimicrobial susceptibility testing (AST) is presented using microstructured silicon diffraction gratings integrated into prototype devices, which enhance bacteria-surface interactions and promote bacterial colonization. The silicon microstructures act also as optical sensors for monitoring bacterial growth upon exposure to antibiotics in a real-time and label-free manner via intensity-based phase-shift reflectometric interference spectroscopic measurements (iPRISM)...
August 16, 2023: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/37577849/the-dilatable-membrane-of-oleosomes-lipid-droplets-allows-their-in-vitro-resizing-and-triggered-release-of-lipids
#14
JOURNAL ARTICLE
Eleni Ntone, Benjamin Rosenbaum, Simha Sridharan, Stan B J Willems, Othonas A Moultos, Thijs J H Vlugt, Marcel B J Meinders, Leonard M C Sagis, Johannes H Bitter, Constantinos V Nikiforidis
It has been reported that lipid droplets (LDs), called oleosomes, have an inherent ability to inflate or shrink when absorbing or fueling lipids in the cells, showing that their phospholipid/protein membrane is dilatable. This property is not that common for membranes stabilizing oil droplets and when well understood, it could be exploited for the design of responsive and metastable droplets. To investigate the nature of the dilatable properties of the oleosomes, we extracted them from rapeseeds to obtain an oil-in-water emulsion...
August 14, 2023: Soft Matter
https://read.qxmd.com/read/37570988/antioxidative-defense-suppressed-nitric-oxide-accumulation-and-synthesis-of-protective-proteins-in-roots-and-leaves-contribute-to-the-desiccation-tolerance-of-the-resurrection-plant-haberlea-rhodopensis
#15
JOURNAL ARTICLE
Katya Georgieva, Gergana Mihailova, Liliana Gigova, Antoaneta V Popova, Maya Velitchkova, Lyudmila Simova-Stoilova, Máté Sági-Kazár, Helga Zelenyánszki, Katalin Solymosi, Ádám Solti
The desiccation tolerance of plants relies on defense mechanisms that enable the protection of macromolecules, biological structures, and metabolism. Although the defense of leaf tissues exposed to solar irradiation is challenging, mechanisms that protect the viability of the roots, yet largely unexplored, are equally important for survival. Although the photosynthetic apparatus in leaves contributes to the generation of oxidative stress under drought stress, we hypothesized that oxidative stress and thus antioxidative defense is also predominant in the roots...
July 31, 2023: Plants (Basel, Switzerland)
https://read.qxmd.com/read/37559222/early-treatment-of-acetabular-fractures-via-an-anterior-approach-increases-blood-loss-but-not-packed-red-blood-cell-transfusion
#16
JOURNAL ARTICLE
Brian H Mullis, Joshua Hs Chang, Nihar Shah, Ramsey S Sabbagh, Qing Yu, Michael T Archdeacon, H Claude Sagi, Roman M Natoli
OBJECTIVE: To determine if time from hospital admission to surgery for acetabular fractures using an anterior intrapelvic (AIP) approach affected blood loss. DESIGN: Multicenter retrospective study. SETTING: Three level 1 trauma centers at 2 academic institutions. PATIENTS: 195 adult (age >18) patients with adequate records to complete analysis and no pre-existing coagulopathy. INTERVENTION: AIP approach without other significant same day procedures (irrigation and debridement and external fixation were the only other allowed procedures)...
August 9, 2023: Journal of Orthopaedic Trauma
https://read.qxmd.com/read/37540002/desalination-water-re-use-and-halophyte-cultivation-in-salinized-regions-a-highly-productive-groundwater-treatment-system
#17
JOURNAL ARTICLE
Kiho Park, Anurag Mudgal, Varsha Mudgal, Moshe Sagi, Dominic Standing, Philip A Davies
Groundwater salinization is a problem affecting access to water in many world regions. Though desalination by conventional reverse osmosis (RO) can upgrade groundwater quality for drinking, its disadvantages include unmanaged brine discharge and accelerated groundwater depletion. Here, we propose a new approach combining RO, forward osmosis (FO), and halophyte cultivation, in which FO optimally adjusts the concentration of the RO reject brine for irrigation of Salicornia or Sarcocornia . The FO also re-uses wastewater, thus, reducing groundwater extraction and the wastewater effluent volume...
August 4, 2023: Environmental Science & Technology
https://read.qxmd.com/read/37499547/the-emulsifying-ability-of-oleosomes-and-their-interfacial-molecules
#18
JOURNAL ARTICLE
Eleni Ntone, Jack Yang, Marcel B J Meinders, Johannes H Bitter, Leonard M C Sagis, Constantinos V Nikiforidis
Oleosomes are natural oil droplets, present in all organisms and abundant in oilseeds. After their aqueous extraction from oilseeds, they can be directly utilized as oil droplets in food, cosmetics and all types of oil-in-water emulsion systems. However, to expand the potential uses of oleosomes as green ingredients and to valorize oilseeds as efficient as possible, we explored their emulsifying ability. Oleosomes were extracted from rapeseeds, and 10.0 wt% oil-in-water emulsions were created after homogenization with 0...
July 24, 2023: Colloids and Surfaces. B, Biointerfaces
https://read.qxmd.com/read/37402873/lifestyle-interventions-in-nonalcoholic-fatty-liver-disease
#19
REVIEW
Zobair M Younossi, Shira Zelber-Sagi, Linda Henry, Lynn H Gerber
Nonalcoholic fatty liver disease (NAFLD) is a dynamic chronic liver disease that develops in close association with metabolic irregularities. Between 2016 and 2019, the global prevalence among adults was reported as 38% and among children and adolescents it was about 10%. NAFLD can be progressive and is associated with increased mortality from cardiovascular disease, extrahepatic cancers and liver complications. Despite these numerous adverse outcomes, no pharmacological treatments currently exist to treat nonalcoholic steatohepatitis, the progressive form of NAFLD...
November 2023: Nature Reviews. Gastroenterology & Hepatology
https://read.qxmd.com/read/37354706/antibiotic-duration-following-abdominal-gunshot-injuries-with-associated-pelvis-or-spine-involvement-a-20-year-single-center-experience
#20
JOURNAL ARTICLE
Lauren Michelle Dehne, Madeline Jane Foertsch, Christopher Allen Droege, Amy Teres Makley, Daniel Ronald Mosher, Carolyn Dosen Philpott, Henry Claude Sagi, Eric William Mueller, Molly Elizabeth Droege
INTRODUCTION: Optimal antimicrobial prophylaxis duration following gunshot wounds (GSW) to the abdomen with an associated orthopedic fracture is unknown. This study evaluated the safety and efficacy of short versus long courses of prophylactic antibiotics following penetrating hollow viscus injury with communicating orthopedic fracture. METHODS: This retrospective study included adult patients admitted to the trauma service over a 20-y period who sustained an abdominal GSW with hollow viscus injury and communicating spine or pelvic fractures...
June 22, 2023: Journal of Surgical Research
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