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https://www.readbyqxmd.com/read/28631745/achieving-assessor-accuracy-on-the-international-standards-for-neurological-classification-of-spinal-cord-injury
#1
A J Armstrong, J M Clark, D T Ho, C J Payne, S Nolan, L M Goodes, L A Harvey, R Marshall, M P Galea, S A Dunlop
STUDY DESIGN: A retrospective audit of assessor accuracy using the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) in three multicentre randomised controlled trials (SCIPA: Spinal Cord Injury and Physical Activity) spanning 2010-2014 with standards revised in 2011. OBJECTIVES: To investigate assessor accuracy of neurological classification after spinal cord injury. SETTING: Australia and New Zealand...
June 20, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28536093/development-of-trust-in-an-online-breast-cancer-forum-a-qualitative-study
#2
Melanie Lovatt, Peter A Bath, Julie Ellis
BACKGROUND: Online health forums provide peer support for a range of medical conditions including life-threatening and terminal illnesses. Trust is an important component of peer-to-peer support, although relatively little is known about how trust forms within online health forums. OBJECTIVE: The aim of this paper is to examine how trust develops and influences sharing among users of an online breast cancer forum. METHODS: An interpretive qualitative approach was adopted...
May 23, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28485597/photoaquation-mechanism-of-hexacyanoferrate-ii-ions-ultrafast-2d-uv-and-transient-visible-and-ir-spectroscopies
#3
Marco Reinhard, Gerald Auböck, Nicholas A Besley, Ian P Clark, Gregory M Greetham, Magnus W D Hanson-Heine, Raphael Horvath, Thomas S Murphy, Thomas J Penfold, Michael Towrie, Michael W George, Majed Chergui
Ferrous iron(II) hexacyanide in aqueous solutions is known to undergo photoionization and photoaquation reactions depending on the excitation wavelength. To investigate this wavelength dependence, we implemented ultrafast two-dimensional UV transient absorption spectroscopy, covering a range from 280 to 370 nm in both excitation and probing, along with UV pump/visible probe or time-resolved infrared (TRIR) transient absorption spectroscopy and density functional theory (DFT) calculations. As far as photoaquation is concerned, we find that excitation of the molecule leads to ultrafast intramolecular relaxation to the lowest triplet state of the [Fe(CN)6](4-) complex, followed by its dissociation into CN(-) and [Fe(CN)5](3-) fragments and partial geminate recombination, all within <0...
May 18, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28439809/site-selection-a-case-study-in-the-identification-of-optimal-cysteine-engineered-antibody-drug-conjugates
#4
L Nathan Tumey, Fengping Li, Brian Rago, Xiaogang Han, Frank Loganzo, Sylvia Musto, Edmund I Graziani, Sujiet Puthenveetil, Jeffrey Casavant, Kimberly Marquette, Tracey Clark, Jack Bikker, Eric M Bennett, Frank Barletta, Nicole Piche-Nicholas, Amy Tam, Christopher J O'Donnell, Hans Peter Gerber, Lioudmila Tchistiakova
As the antibody drug conjugate (ADC) community continues to shift towards site-specific conjugation technology, there is a growing need to understand how the site of conjugation impacts the biophysical and biological properties of an ADC. In order to address this need, we prepared a carefully selected series of engineered cysteine ADCs and proceeded to systematically evaluate their potency, stability, and PK exposure. The site of conjugation did not have a significant influence on the thermal stability and in vitro cytotoxicity of the ADCs...
April 24, 2017: AAPS Journal
https://www.readbyqxmd.com/read/28420054/the-prevalence-and-determinants-of-anti-dfs70-autoantibodies-in-an-international-inception-cohort-of-systemic-lupus-erythematosus-patients
#5
M Y Choi, A E Clarke, Y St Pierre, J G Hanly, M B Urowitz, J Romero-Diaz, C Gordon, S-C Bae, S Bernatsky, D J Wallace, J T Merrill, D A Isenberg, A Rahman, E M Ginzler, M Petri, I N Bruce, M A Dooley, P Fortin, D D Gladman, J Sanchez-Guerrero, K Steinsson, R Ramsey-Goldman, M A Khamashta, C Aranow, G S Alarcón, S Manzi, O Nived, A A Zoma, R F van Vollenhoven, M Ramos-Casals, G Ruiz-Irastorza, S S Lim, K C Kalunian, M Inanc, D L Kamen, C A Peschken, S Jacobsen, A Askanase, J Buyon, M Mahler, M J Fritzler
Autoantibodies to dense fine speckles 70 (DFS70) are purported to rule out the diagnosis of SLE when they occur in the absence of other SLE-related autoantibodies. This study is the first to report the prevalence of anti-DFS70 in an early, multinational inception SLE cohort and examine demographic, clinical, and autoantibody associations. Patients were enrolled in the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort within 15 months of diagnosis. The association between anti-DFS70 and multiple parameters in 1137 patients was assessed using univariate and multivariate logistic regression...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28407555/thalamocortical-connectivity-in-major-depressive-disorder
#6
Elliot C Brown, Darren L Clark, Stefanie Hassel, Glenda MacQueen, Rajamannar Ramasubbu
BACKGROUND: Major Depressive Disorder (MDD) is highly prevalent and potentially devastating, with widespread aberrations in brain activity. Thalamocortical networks are a potential candidate marker for psychopathology in MDD, but have not yet been thoroughly investigated. Here we examined functional connectivity between major cortical areas and thalamus. METHOD: Resting-state fMRI from 54 MDD patients and 40 healthy controls were collected. The cortex was segmented into six regions of interest (ROIs) consisting of frontal, temporal, parietal, and occipital lobes and pre-central and post-central gyri...
August 1, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28371642/the-impact-of-social-threat-cues-on-a-card-sorting-task-with-attentional-shifting-demands
#7
Jan Mohlman, Alyssa DeVito
BACKGROUND AND OBJECTIVES: The current study investigated social anxiety and attentional control using two versions of a task designed to tap intentional shifting of attention and set switching: the standard Wisconsin Card Sorting Test (WCST; Heaton, 1981) and a modified version that included emotionally salient pictorial stimuli, the Emotional Faces Card Sorting Test (EFCST). A Group (lower-, higher-SPS) by Condition (WCST, EFCST) by Sorting Rule (color, form, number) interaction was expected in which the higher-SPS EFCST group would have worse overall performance and make more perseverative errors than the other groups...
March 7, 2017: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/28195683/evaluation-of-smartstax-and-smartstax%C3%A2-pro-maize-against-western-corn-rootworm-and-northern-corn-rootworm-efficacy-and-resistance-management
#8
Graham P Head, Matthew Carroll, Sean Evans, Dwain M Rule, Alan Willse, Thomas Clark, Nicholas Storer, Ronald Flannagan, Luke Samuel, Lance J Meinke
BACKGROUND: Cases of western corn rootworm (WCR) field-evolved resistance to Cry3Bb1 and other corn rootworm (CRW) control traits have been reported. Pyramid products expressing multiple CRW traits can delay resistance compared to single trait products. We used field studies to assess the pyramid CRW corn products, SmartStax (expressing Cry3Bb1 and Cry34Ab1/Cry35Ab1) and SmartStax PRO (expressing Cry3Bb1, Cry34Ab1/Cry35Ab1 and DvSnf7), at locations with high WCR densities and possible Cry3Bb1 resistance, and to assess the reduction in adult emergence attributable to DvSnf7 and other traits...
February 13, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28181102/cerebrospinal-fluid-nlrp3-is-increased-after-severe-traumatic-brain-injury-in-infants-and-children
#9
Jessica S Wallisch, Dennis W Simon, Hülya Bayır, Michael J Bell, Patrick M Kochanek, Robert S B Clark
BACKGROUND: Inflammasome-mediated neuroinflammation may cause secondary injury following traumatic brain injury (TBI) in children. The pattern recognition receptors NACHT domain-, Leucine-rich repeat-, and PYD-containing Protein 1 (NLRP1) and NLRP3 are essential components of their respective inflammasome complexes. We sought to investigate whether NLRP1 and/or NLRP3 abundance is altered in children with severe TBI. METHODS: Cerebrospinal fluid (CSF) from children (n = 34) with severe TBI (Glasgow coma scale score [GCS] ≤8) who had externalized ventricular drains (EVD) placed for routine care was evaluated for NLRP1 and NLRP3 at 0-24, 25-48, 49-72, and >72 h post-TBI and was compared to infection-free controls that underwent lumbar puncture to rule out CNS infection (n = 8)...
February 8, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/28095957/point-of-care-ultrasound-utility-and-potential-for-high-altitude-crew-recovery-missions
#10
REVIEW
Laura A Galdamez, Jonathan B Clark, Erik L Antonsen
INTRODUCTION: Flights to high altitude can lead to exposure and unique pathology not seen in normal commercial aviation. METHODS: This paper assesses the potential for point-of-care ultrasound to aid in management and disposition of injured crewmembers from a high altitude incident. This was accomplished through a systematic literature review regarding current diagnostic and therapeutic uses of ultrasound for injuries expected in high altitude free fall and parachuting...
February 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28031284/drug-drug-interaction-discovery-and-demystification-using-semantic-web-technologies
#11
Adeeb Noor, Abdullah Assiri, Serkan Ayvaz, Connor Clark, Michel Dumontier
Objective: To develop a novel pharmacovigilance inferential framework to infer mechanistic explanations for asserted drug-drug interactions (DDIs) and deduce potential DDIs. Materials and Methods: A mechanism-based DDI knowledge base was constructed by integrating knowledge from several existing sources at the pharmacokinetic, pharmacodynamic, pharmacogenetic, and multipathway interaction levels. A query-based framework was then created to utilize this integrated knowledge base in conjunction with 9 inference rules to infer mechanistic explanations for asserted DDIs and deduce potential DDIs...
May 1, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/27884848/are-differences-in-travel-time-or-distance-to-healthcare-for-adults-in-global-north-countries-associated-with-an-impact-on-health-outcomes-a-systematic-review
#12
Charlotte Kelly, Claire Hulme, Tracey Farragher, Graham Clarke
OBJECTIVES: To investigate whether there is an association between differences in travel time/travel distance to healthcare services and patients' health outcomes and assimilate the methodologies used to measure this. DESIGN: Systematic Review. We searched MEDLINE, Embase, Web of Science, Transport database, HMIC and EBM Reviews for studies up to 7 September 2016. Studies were excluded that included children (including maternity), emergency medical travel or countries classed as being in the global south...
November 24, 2016: BMJ Open
https://www.readbyqxmd.com/read/27819414/a-6-point-tacs-score-predicts-in-hospital-mortality-following-total-anterior-circulation-stroke
#13
Adrian D Wood, Nicholas D Gollop, Joao H Bettencourt-Silva, Allan B Clark, Anthony K Metcalf, Kristian M Bowles, Marcus D Flather, John F Potter, Phyo Kyaw Myint
BACKGROUND AND PURPOSE: Little is known about the factors associated with in-hospital mortality following total anterior circulation stroke (TACS). We examined the characteristics and comorbidity data for TACS patients in relation to in-hospital mortality with the aim of developing a simple clinical rule for predicting the acute mortality outcome in TACS. METHODS: A routine data registry of one regional hospital in the UK was analyzed. The subjects were 2,971 stroke patients with TACS (82% ischemic; median age=81 years, interquartile age range=74-86 years) admitted between 1996 and 2012...
October 2016: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/27648919/prediction-of-transition-from-ultra-high-risk-to-first-episode-psychosis-using-a-probabilistic-model-combining-history-clinical-assessment-and-fatty-acid-biomarkers
#14
S R Clark, B T Baune, K O Schubert, S Lavoie, S Smesny, S M Rice, M R Schäfer, F Benninger, M Feucht, C M Klier, P D McGorry, G P Amminger
Current criteria identifying patients with ultra-high risk of psychosis (UHR) have low specificity, and less than one-third of UHR cases experience transition to psychosis within 3 years of initial assessment. We explored whether a Bayesian probabilistic multimodal model, combining baseline historical and clinical risk factors with biomarkers (oxidative stress, cell membrane fatty acids, resting quantitative electroencephalography (qEEG)), could improve this specificity. We analyzed data of a UHR cohort (n=40) with a 1-year transition rate of 28%...
2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27525481/odd-paired-controls-frequency-doubling-in-drosophila-segmentation-by-altering-the-pair-rule-gene-regulatory-network
#15
Erik Clark, Michael Akam
The Drosophila embryo transiently exhibits a double-segment periodicity, defined by the expression of seven 'pair-rule' genes, each in a pattern of seven stripes. At gastrulation, interactions between the pair-rule genes lead to frequency doubling and the patterning of 14 parasegment boundaries. In contrast to earlier stages of Drosophila anteroposterior patterning, this transition is not well understood. By carefully analysing the spatiotemporal dynamics of pair-rule gene expression, we demonstrate that frequency-doubling is precipitated by multiple coordinated changes to the network of regulatory interactions between the pair-rule genes...
August 15, 2016: ELife
https://www.readbyqxmd.com/read/27519800/making-technological-innovation-work-for-sustainable-development
#16
Laura Diaz Anadon, Gabriel Chan, Alicia G Harley, Kira Matus, Suerie Moon, Sharmila L Murthy, William C Clark
This paper presents insights and action proposals to better harness technological innovation for sustainable development. We begin with three key insights from scholarship and practice. First, technological innovation processes do not follow a set sequence but rather emerge from complex adaptive systems involving many actors and institutions operating simultaneously from local to global scales. Barriers arise at all stages of innovation, from the invention of a technology through its selection, production, adaptation, adoption, and retirement...
August 30, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27515631/a-new-monotypic-genus-a-species-synonymy-and-nomenclatural-corrections-in-the-arid-adapted-canthonini-scarabaeidae-scarabaeinae-from-the-succulent-karoo-biome-of-south-western-africa
#17
Christian M Deschodt, Adrian L V Davis, Clarke H Scholtz
Although it has been demonstrated that the tribe Canthonini (Scarabaeidae: Scarabaeinae) is polyphyletic, those canthonine genera occurring in arid south-western Africa apparently form a monophyletic group. In this paper we add one new monotypic genus, Drogo stalsi gen. et. sp. n. to this group, and synonymize another member, Byrrhidium namaquense Scholtz and Howden, 1987 syn. n. with Byrrhidium ovale Harold, 1869. We correct the spelling of two species names that were not in agreement with the gender rule...
August 5, 2016: Zootaxa
https://www.readbyqxmd.com/read/27503195/abstract-concept-learning-in-black-billed-magpies-pica-hudsonia
#18
John F Magnotti, Anthony A Wright, Kevin Leonard, Jeffrey S Katz, Debbie M Kelly
relational concepts depend upon relationships between stimuli (e.g., same vs. different) and transcend features of the training stimuli. Recent evidence shows that learning abstract concepts is shared across a variety species including birds. Our recent work with a highly-skilled food-storing bird, Clark's nutcracker, revealed superior same/different abstract-concept learning compared to rhesus monkeys, capuchin monkeys, and pigeons. Here we test a more social, but less reliant on food-storing, corvid species, the Black-billed magpie (Pica hudsonia)...
April 2017: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/27499408/pan-computed-tomography-for-blunt-polytrauma-are-we-doing-too-many
#19
G V Oosthuizen, J L Bruce, W Bekker, N Shangase, G L Laing, D L Clarke
BACKGROUND: Pan computed tomography (CT) is widely used in the evaluation of patients with blunt polytrauma, but there is growing concern about the radiation risks imposed. OBJECTIVE: To ascertain whether we were possibly overutilising pan CT in our trauma service, and whether we could safely cut down on scans without missing significant injuries. METHODS: We audited all pan scans performed in the Metropolitan Trauma Service, Pietermaritzburg, South Africa, during the 12-month period 1 January - 31 December 2012...
July 7, 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/27400318/detection-of-transmissible-viral-proventriculitis-and-chicken-proventricular-necrosis-virus-in-the-uk
#20
Llorenç Grau-Roma, Kirsty Reid, Simone de Brot, Richard Jennison, Paul Barrow, Raúl Sánchez, Miquel Nofrarías, Mike Clark, Natàlia Majó
Increasing evidence suggests that a new birnavirus, named chicken proventricular necrosis virus (CPNV), is the aetiological agent of transmissible viral proventriculitis (TVP). The present work aimed to explore the possible presence of both TVP and CPNV in the UK. Forty-four chickens showing TVP-compatible gross lesions were classified into three groups based on the histological lesions: (i) TVP-affected chickens: lymphocytic infiltration and glandular necrosis (n = 15); (ii) lymphocytic proventriculitis (LP)-affected chickens: lymphocytic infiltration without necrosis (n = 18); and (iii) without proventriculitis (WP): no lymphocytic infiltration or necrosis (n = 11)...
February 2017: Avian Pathology: Journal of the W.V.P.A
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