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https://www.readbyqxmd.com/read/29774517/the-acute-effects-of-age-and-particulate-matter-exposure-on-heart-rate-and-heart-rate-variability-in-mice
#1
Blake A Bennett, Ernst W Spannhake, Ana M Rule, Patrick N Breysse, Clarke G Tankersley
Exposure to ambient particulate matter (PM) is associated with increased cardiac morbidity and mortality with the elderly considered to be the most susceptible. The purpose of this study was to determine if exposure to PM would cause a greater impact on heart regulation in older DBA/2 (D2) male mice as determined by changes in heart rate (HR) and heart rate variability (HRV). D2 mice at the ages of 4, 12, and 19 months were instilled with 100 µg of PM or saline by aspiration. Before and after the aspiration, 3-min echocardiogram (ECG) samples for HR and HRV were recorded at 15-min intervals for 3 h along with corresponding measurements of homeostasis, such as temperature, metabolism, and ventilation...
May 17, 2018: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/29737976/uniform-resolution-of-compact-identifiers-for-biomedical-data
#2
Sarala M Wimalaratne, Nick Juty, John Kunze, Greg Janée, Julie A McMurry, Niall Beard, Rafael Jimenez, Jeffrey S Grethe, Henning Hermjakob, Maryann E Martone, Tim Clark
Most biomedical data repositories issue locally-unique accessions numbers, but do not provide globally unique, machine-resolvable, persistent identifiers for their datasets, as required by publishers wishing to implement data citation in accordance with widely accepted principles. Local accessions may however be prefixed with a namespace identifier, providing global uniqueness. Such "compact identifiers" have been widely used in biomedical informatics to support global resource identification with local identifier assignment...
May 8, 2018: Scientific Data
https://www.readbyqxmd.com/read/29724758/evidence-for-the-temporal-regulation-of-insect-segmentation-by-a-conserved-sequence-of-transcription-factors
#3
Erik Clark, Andrew D Peel
Long-germ insects, such as the fruit fly Drosophila melanogaster , pattern their segments simultaneously, whereas short-germ insects, such as the beetle Tribolium castaneum , pattern their segments sequentially, from anterior to posterior. While the two modes of segmentation at first appear quite distinct, much of this difference might simply reflect developmental heterochrony. We now show here that, in both Drosophila and Tribolium , segment patterning occurs within a common framework of sequential Caudal, Dichaete, and Odd-paired expression...
May 3, 2018: Development
https://www.readbyqxmd.com/read/29716595/factorial-structure-of-the-locomotor-disability-scale-in-a-sample-of-adults-with-mobility-impairments-in-bangladesh
#4
Ilias Mahmud, Lynda Clarke, Nazmun Nahar, George B Ploubidis
BACKGROUND: Disability does not only depend on individuals' health conditions but also the contextual factors in which individuals live. Therefore, disability measurement scales need to be developed or adapted to the context. Bangladesh lacks any locally developed or validated scales to measure disabilities in adults with mobility impairment. We developed a new Locomotor Disability Scale (LDS) in a previous qualitative study. The present study developed a shorter version of the scale and explored its factorial structure...
May 2, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29710751/in-vivo-noninvasive-blood-glucose-detection-using-near-infrared-spectrum-based-on-the-pso-2ann-model
#5
Juan Dai, Zhong Ji, Yubao Du, Shuo Chen
BACKGROUND: To improving the nursing level of diabetics, it is necessary to develop noninvasive blood glucose method. OBJECTIVE: In order to reduce the number of the near-infrared signal, consider the nonlinear relationship between the blood glucose concentration and near-infrared signal, and correct the individual difference and physiological glucose dynamic, 2 artificial neural networks (2ANN) combined with particle swarm optimization (PSO), named as PSO-2ANN, is proposed...
April 16, 2018: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/29666384/numerical-simulations-of-a-kilometre-thick-arctic-ice-shelf-consistent-with-ice-grounding-observations
#6
Edward G W Gasson, Robert M DeConto, David Pollard, Chris D Clark
Recently obtained geophysical data show sets of parallel erosional features on the Lomonosov Ridge in the central Arctic Basin, indicative of ice grounding in water depths up to 1280 m. These features have been interpreted as being formed by an ice shelf-either restricted to the Amerasian Basin (the "minimum model") or extending across the entire Arctic Basin. Here, we use a numerical ice sheet-shelf model to explore how such an ice shelf could form. We rule out the "minimum model" and suggest that grounding on the Lomonosov Ridge requires complete Arctic ice shelf cover; this places a minimum estimate on its volume, which would have exceeded that of the modern Greenland Ice Sheet...
April 17, 2018: Nature Communications
https://www.readbyqxmd.com/read/29627817/quantitative-fibronectin-to-help-decision-making-in-women-with-symptoms-of-preterm-labour-quids-part-1-individual-participant-data-meta-analysis-and-health-economic-analysis
#7
Sarah J Stock, Lisa M Wotherspoon, Kathleen A Boyd, Rachel K Morris, Jon Dorling, Lesley Jackson, Manju Chandiramani, Anna L David, Asma Khalil, Andrew Shennan, Victoria Hodgetts Morton, Tina Lavender, Khalid Khan, Susan Harper-Clarke, Ben W Mol, Richard D Riley, John Norrie, Jane E Norman
INTRODUCTION: The aim of the QUIDS study is to develop a decision support tool for the management of women with symptoms and signs of preterm labour, based on a validated prognostic model using quantitative fetal fibronectin (qfFN) concentration, in combination with clinical risk factors. METHODS AND ANALYSIS: The study will evaluate the Rapid fFN 10Q System (Hologic, Marlborough, Massachusetts) which quantifies fFN in a vaginal swab. In part 1 of the study, we will develop and internally validate a prognostic model using an individual participant data (IPD) meta-analysis of existing studies containing women with symptoms of preterm labour alongside fFN measurements and pregnancy outcome...
April 7, 2018: BMJ Open
https://www.readbyqxmd.com/read/29603545/tunable-pentapeptide-self-assembled-%C3%AE-sheet-hydrogels
#8
David E Clarke, Christopher D J Parmenter, Oren A Scherman
Oligopeptide-based supramolecular hydrogels hold promise in a range of applications. The gelation of these systems is hard to control with minor alterations in the peptide sequence significantly influencing the self-assembly process. This makes sequence design difficult whereby typical self-assembly rules cannot be applied. We explored the design of pentapeptide sequences with different charge distributions and discovered that they formed robust, pH-responsive hydrogels. Through altering the concentration and charge distribution of the peptide sequence, we demonstrated that the stiffness of the hydrogels can be tuned across two orders of magnitude (2-200 kPa)...
March 30, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29574193/nonclinical-assessments-of-the-potential-biosimilar-pf-06439535-and-bevacizumab
#9
Marjorie A Peraza, Karen E Rule, Michael H I Shiue, Gregory L Finch, Stéphane Thibault, Paul R Brown, David W Clarke, Michael W Leach
Bevacizumab, a recombinant humanized monoclonal antibody targeting vascular endothelial growth factor (VEGF), is approved for treatment of metastatic colorectal cancer, nonsquamous non-small-cell lung cancer, metastatic kidney cancer, and glioblastoma. To support clinical development of the potential bevacizumab biosimilar PF-06439535, nonclinical studies evaluated structural, functional, toxicological, and toxicokinetic similarity to bevacizumab sourced from the European Union (bevacizumab-EU) and United States (bevacizumab-US)...
March 21, 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29555253/accuracy-of-routine-endoscopy-diagnosing-colonic-ischaemia-after-abdominal-aortic-aneurysm-repair-a-meta-analysis
#10
REVIEW
Gerdine C I von Meijenfeldt, Tryfon Vainas, George A Mistiotis, Sarah L Gans, Clark J Zeebregts, Maarten J van der Laan
BACKGROUND: Colonic ischaemia (CI) is a devastating complication after abdominal aortic aneurysm (AAA) surgery. The aim of this review was to evaluate the diagnostic test accuracy of routine endoscopy in diagnosing CI after treatment for elective and acute AAA. PATIENTS AND METHODS: The Pubmed and Embase database searches resulted in 1188 articles. Prospective studies describing routine post-operative colonoscopy or sigmoidoscopy after elective or emergency AAA repair were included...
March 16, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29513754/using-bluetooth-proximity-sensing-to-determine-where-office-workers-spend-time-at-work
#11
Bronwyn K Clark, Elisabeth A Winkler, Charlotte L Brakenridge, Stewart G Trost, Genevieve N Healy
BACKGROUND: Most wearable devices that measure movement in workplaces cannot determine the context in which people spend time. This study examined the accuracy of Bluetooth sensing (10-second intervals) via the ActiGraph GT9X Link monitor to determine location in an office setting, using two simple, bespoke algorithms. METHODS: For one work day (mean±SD 6.2±1.1 hours), 30 office workers (30% men, aged 38±11 years) simultaneously wore chest-mounted cameras (video recording) and Bluetooth-enabled monitors (initialised as receivers) on the wrist and thigh...
2018: PloS One
https://www.readbyqxmd.com/read/29505833/knee-flexion-strength-is-significantly-reduced-following-competition-in-semi-professional-australian-rules-football-athletes-implications-for-injury-prevention-programs
#12
Paula C Charlton, Benjamin Raysmith, Martin Wollin, Simon Rice, Craig Purdam, Ross A Clark, Michael K Drew
OBJECTIVES: To evaluate strength and flexibility measures pre- and post- Australian Football (AF) competition to determine their potential utility as secondary prevention measures. DESIGN: Cohort study. SETTING: Semi-professional AF club. PARTICIPANTS: Ten male AF athletes (mean ± SD; age, 21.3 ± 2.2 years; height, 186.1 ± 6.3 cm; weight, 83.5 ± 8.6 kg). MAIN OUTCOME MEASURES: Maximal unilateral isometric knee flexion strength performed in 45 degrees of hip flexion and 30 degrees of knee flexion, flexibility measures of hip and knee extension and ankle dorsiflexion...
May 2018: Physical Therapy in Sport
https://www.readbyqxmd.com/read/29490133/multi-state-valbond-for-atomistic-simulations-of-hypervalent-molecules-metal-complexes-and-reactions
#13
Maurus Hans Schmid, Akshaya Kumar Das, Clark R Landis, Markus Meuwly
The implementation, validation and application of the Multi-State VALBOND (MS-VALBOND) method for transition metal-containing and hypervalent molecules is presented. This approach is particularly suited for molecules with unusual shapes and systems that need to be described by a superposition of resonance structures, each of which satisfies the octet rule. The implementation is based on the original VALBOND force field and allows to smoothly switch between resonance structures, each of which can be characterized by its own force field, including varying charge distributions, and coupling terms between the states...
February 28, 2018: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29414471/assessing-women-s-lacrosse-head-impacts-using-finite-element-modelling
#14
J Michio Clark, T Blaine Hoshizaki, Michael D Gilchrist
Recently studies have assessed the ability of helmets to reduce peak linear and rotational acceleration for women's lacrosse head impacts. However, such measures have had low correlation with injury. Maximum principal strain interprets loading curves which provide better injury prediction than peak linear and rotational acceleration, especially in compliant situations which create low magnitude accelerations but long impact durations. The purpose of this study was to assess head and helmet impacts in women's lacrosse using finite element modelling...
April 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29392095/rethinking-childhood-adversity-in-chronic-fatigue-syndrome
#15
James E Clark, Sean L Davidson, Laura Maclachlan, Julia L Newton, Stuart Watson
Background: Previous studies have consistently shown increased rates of childhood adversity in chronic fatigue syndrome (CFS). However, such aetiopathogenic studies of CFS are potentially confounded by co-morbidity and misdiagnosis particularly with depression. Purpose: We examined the relationship between rates of childhood adversity using two complimentary approaches (1) a sample of CFS patients who had no lifetime history of depression and (2) a modelling approach. Methods: Childhood trauma questionnaire (CTQ) administered to a sample of 52 participants with chronic fatigue syndrome and 19 controls who did not meet criteria for a psychiatric disorder (confirmed using the Structured Clinical Interview for DSM-IV)...
2018: Fatigue: Biomedicine, Health and Behavior
https://www.readbyqxmd.com/read/29337578/physiologically-based-pharmacokinetic-modeling-in-lead-optimization-1-evaluation-and-adaptation-of-gastroplus-to-predict-bioavailability-of-medchem-series
#16
Pankaj R Daga, Michael B Bolger, Ian S Haworth, Robert D Clark, Eric J Martin
When medicinal chemists need to improve bioavailability (%F) within a chemical series during lead optimization, they synthesize new series members with systematically modified properties mainly by following experience and general rules of thumb. More quantitative models that predict %F of proposed compounds from chemical structure alone have proven elusive. Global empirical %F quantitative structure-property (QSPR) models perform poorly, and projects have too little data to train local %F QSPR models. Mechanistic oral absorption and physiologically based pharmacokinetic (PBPK) models simulate the dissolution, absorption, systemic distribution, and clearance of a drug in preclinical species and humans...
March 5, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29337562/physiologically-based-pharmacokinetic-modeling-in-lead-optimization-2-rational-bioavailability-design-by-global-sensitivity-analysis-to-identify-properties-affecting-bioavailability
#17
Pankaj R Daga, Michael B Bolger, Ian S Haworth, Robert D Clark, Eric J Martin
When medicinal chemists need to improve oral bioavailability (%F) during lead optimization, they systematically modify compound properties mainly based on their own experience and general rules of thumb. However, at least a dozen properties can influence %F, and the difficulty of multiparameter optimization for such complex nonlinear processes grows combinatorially with the number of variables. Furthermore, strategies can be in conflict. For example, adding a polar or charged group will generally increase solubility but decrease permeability...
March 5, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29273092/nitrated-nucleosome-levels-and-neuropsychiatric-events-in-systemic-lupus-erythematosus-a-multi-center-retrospective-case-control-study
#18
Isabel Ferreira, Sara Croca, Maria Gabriella Raimondo, Manjit Matharu, Sarah Miller, Ian Giles, David Isenberg, Yiannis Ioannou, John G Hanly, Murray B Urowitz, Nicole Anderson, Cynthia Aranow, Anca Askanase, Sang-Cheol Bae, Sasha Bernatsky, Ian N Bruce, Jill Buyon, Ann E Clarke, Mary Anne Dooley, Paul Fortin, Ellen Ginzler, Dafna Gladman, Caroline Gordon, Murat Inanc, Søren Jacobsen, Kenneth Kalunian, Diane Kamen, Munther Khamashta, Sam Lim, Susan Manzi, Joan Merrill, Ola Nived, Christine Peschken, Michelle Petri, Rosalind Ramsey-Goldman, Guillermo Ruiz-Irastorza, Jorge Sanchez-Guerrero, Kristjan Steinson, Gunnar K Sturfelt, Ronald van Vollenhoven, Daniel J Wallace, Asad Zoma, Anisur Rahman
BACKGROUND: In patients with systemic lupus erythematosus (SLE) there is no serological test that will reliably distinguish neuropsychiatric (NP) events due to active SLE from those due to other causes. Previously we showed that serum levels of nitrated nucleosomes (NN) were elevated in a small number of patients with NPSLE. Here we measured serum NN in samples from a larger population of patients with SLE and NP events to see whether elevated serum NN could be a marker for NPSLE. METHODS: We obtained serum samples from patients in the Systemic Lupus International Collaborative Clinics (SLICC) inception cohort...
December 22, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29186630/music-models-aberrant-rule-decoding-and-reward-valuation-in-dementia
#19
Camilla N Clark, Hannah L Golden, Oliver McCallion, Jennifer M Nicholas, Miriam H Cohen, Catherine F Slattery, Ross W Paterson, Phillip D Fletcher, Catherine J Mummery, Jonathan D Rohrer, Sebastian J Crutch, Jason D Warren
Aberrant rule- and reward-based processes underpin abnormalities of socio-emotional behaviour in major dementias. However, these processes remain poorly characterized. Here we used music to probe rule decoding and reward valuation in patients with frontotemporal dementia (FTD) syndromes and Alzheimer's disease (AD) relative to healthy age-matched individuals. We created short melodies that were either harmonically resolved ('finished') or unresolved ('unfinished'); the task was to classify each melody as finished or unfinished (rule processing) and rate its subjective pleasantness (reward valuation)...
February 1, 2018: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/29161113/disseminability-of-computerized-cognitive-training-performance-across-coaches
#20
Ashley S Fournier-Goodnight, Jason M Ashford, Kellie N Clark, Karen Martin-Elbahesh, Kristina K Hardy, Thomas E Merchant, Sima Jeha, Robert J Ogg, Hui Zhang, Lei Wang, Heather M Conklin
Cogmed is a computerized cognitive intervention utilizing coaches who receive standardized instruction in analyzing training indices and tailoring feedback to remotely monitor participant's performance. The goal of this study was to examine adherence, satisfaction, and efficacy of Cogmed across coaches. Survivors of pediatric brain tumors and acute lymphoblastic leukemia (N = 68) were randomized to intervention (Cogmed) or waitlist control. The intervention group was matched with one of two coaches. Cognitive assessments were completed before and after intervention, and participants and caregivers in the intervention group completed satisfaction surveys...
November 21, 2017: Applied Neuropsychology. Child
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