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PD Access

Dhanarajan Arunprasath, Balasubramanian Devi Bala, Govindasamy Sekar
An efficient diastereoselective synthesis of α-tetralone-fused spirooxindoles is reported. The Pd-catalyzed domino reaction proceeds through a carbene migratory insertion followed by a 6-endo-trig mode of conjugate addition sequence from easily accessible isatin-derived N-tosylhydrazones and 2'-iodochalcones. The versatility of the protocol has been showcased by high functional group tolerance, broad substrate scope, and extension to an expedient synthesis of spiroacenaphthylenes. NMR reaction profiling and deuterium-labeling investigations provide insight into the mechanistic pathway...
September 22, 2017: Organic Letters
Jian-De Xie, Siyong Gu, Houan Zhang
This work outlines a synthetic strategy inducing the microwave-assisted synthesis of palladium (Pd) nanocrystals on a graphite sphere (GS) and reduced graphene oxide (rGO) supports, forming the Pd catalysts for non-enzymatic glucose oxidation reaction (GOR). The pulse microwave approach takes a short period (i.e., 10 min) to fast synthesize Pd nanocrystals onto a carbon support at 150 °C. The selection of carbon support plays a crucial role in affecting Pd particle size and dispersion uniformity. The robust design of Pd-rGO catalyst electrode displays an enhanced electrocatalytic activity and sensitivity toward GOR...
September 21, 2017: Sensors
Barnaby Hole, Fergus Caskey, Katharine Evans, Richard Fluck, Mick Kumwenda, Retha Steenkamp, Martin Wilkie
No abstract text is available yet for this article.
2017: Nephron
Seth M Pollack, Hailing Lu, Sacha Gnjatic, Neeta Somaiah, Ryan B O'Malley, Robin L Jones, Frank J Hsu, Jan Ter Meulen
Effective induction of antitumor T cells is a pivotal goal of cancer immunotherapy. To this end, lentiviral vectors (LV) are uniquely poised to directly prime CD8 T-cell responses via transduction of dendritic cells in vivo and have shown promise as active cancer therapeutics in preclinical tumor models. However, until now, significant barriers related to production and regulation have prevented their widespread use in the clinic. We developed LV305, a dendritic cell-targeting, integration-deficient, replication incompetent LV from the ZVex platform, encoding the full-length cancer-testis antigen NY-ESO-1...
September 18, 2017: Journal of Immunotherapy
David Yu-Kai Chen
Here we report asymmetric total syntheses of communesin F and a putative member of the communesin family of bis-aminal alkaloid natural products. The successful strategy featured the invention of an asymmetric organocatalytic reaction to unify two oxindole subunits, a Ti(OiPr)4-mediated dehydrative skeletal rearrangement, and a late-stage Pd(OAc)2-catalyzed directed CH-alkenylation reaction. Collectively, the synthetic technologies disclosed herein enabled the preparation of a late-stage polycyclic intermediate catered for the synthesis of both naturally occurring and designed communesins...
September 19, 2017: Angewandte Chemie
S Vichier-Guerre, L Dugué, F Bonhomme, S Pochet
A versatile two-step synthesis of C4- and C5-arylated 2'-deoxyribosylimidazoles was elaborated using enzymatic N-transglycosylation followed by microwave-assisted Pd-catalysed arylation reactions. We report herein the reaction conditions that permit managing regioselectivity (N3 versus N1-isomers) in the enzymatic glycosylation of 4-iodoimidazole using the nucleoside N-deoxyribosyltransferase from L. leichmannii. Regiocontrolled glycosylation was also observed among several other imidazole derivatives studied, providing simple access to isomers not readily accessible by chemical routes...
September 19, 2017: Organic & Biomolecular Chemistry
Jose A Santiago, Judith A Potashkin
BACKGROUND: Substantial progress has been made in the discovery of blood biomarkers for Parkinson's disease (PD), a progressive neurodegenerative disease that affects more than 4 million worldwide. Olfactory dysfunction and dopamine deficits usually precede motor symptoms years before the onset of PD. A readily accessible biomarker useful for identifying patients at risk of PD is expected to accelerate clinical trials. OBJECTIVE: To evaluate previously identified PD blood RNA biomarkers in a cohort of asymptomatic individuals at risk of PD...
September 11, 2017: Journal of Parkinson's Disease
Margarita Kunin, Dganit Dinour, Danny Rosin
BACKGROUND: It is recommended that systemic prophylactic antibiotics be given immediately prior to peritoneal catheter insertion. This administration requires intravenous access and could be inconvenient in dynamic and unpredictable operation room schedule. Intraperitoneal antibiotics could be an alternative simple way for prevention of postoperative peritoneal catheter infections. METHODS: Medical records from 109 patients undergoing permanent PD catheter placement procedures were reviewed retrospectively...
September 14, 2017: Clinical and Experimental Nephrology
Sabrina Giacoppo, Placido Bramanti, Emanuela Mazzon
Several lines of evidence suggest that the inflammasome activation is involved in the progression of neurodegenerative diseases. However, the relation between Parkinson's disease (PD) and the inflammasome is still unclear. This study was designed to assess the involvement of inflammasome in acute experimental PD. Specifically, acute PD was induced in C57BL/6 mice by an injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). At seven days from MPTP induction, mice were euthanized and the midbrains were sampled to carry out immunohistochemical evaluations and western blot analysis...
September 11, 2017: Neuroreport
Eric J Alexy, Scott C Virgil, Michael D Bartberger, Brian M Stoltz
A catalytic, enantioselective decarboxylative allylic alkylation of 4-thiopyranones is reported. The α-quaternary 4-thiopyranones produced are challenging to access by standard enolate alkylation owing to facile ring-opening β-sulfur elimination. In addition, reduction of the carbon-sulfur bonds provides access to elusive acyclic α-quaternary ketones. The alkylated products are obtained in up to 92% yield and 94% enantiomeric excess.
September 13, 2017: Organic Letters
Shicheng Shi, Michal Szostak
Amides are of fundamental interest in many fields of chemistry involving organic synthesis, chemical biology and biochemistry. Here, we report the first catalytic Buchwald-Hartwig coupling of both common esters and amides by highly selective C(acyl)-X (X = O, N) cleavage to rapidly access aryl amide functionality via a cross-coupling strategy. Reactions are promoted by versatile, easily prepared, well-defined Pd-PEPPSI type precatalysts, and proceed in good to excellent yields and with excellent chemoselectivity for the acyl bond cleavage...
September 21, 2017: Chemical Communications: Chem Comm
Brit Long, Alex Koyfman, Courtney M Lee
BACKGROUND: End stage renal disease (ESRD) is increasing in the U.S., and these patients demonstrate greater all-cause mortality, cardiovascular events, and hospitalization rates when compared to those with normal renal function. These patients may experience significant complications associated with loss of renal function and dialysis. OBJECTIVE: This review evaluates complications of ESRD including cardiopulmonary, neurologic, infectious disease, vascular, and access site complications, as well as medication use in this population...
September 5, 2017: American Journal of Emergency Medicine
Idir Benaissa, Rachid Taakili, Noël Lugan, Yves Canac
A series of NHC pre-ligands featuring a pendant phosphonium moiety attached to N' position through a propyl linker was readily obtained upon quaternization of N-mesityl- and N-methyl-imidazole, or N-mesityl-imidazoline using (3-bromo-propyl)-triphenylphosphonium bromide. Reactions of the resulting dicationic salts with [PdCl(allyl)]2 in the presence of K2CO3 afforded the anticipated NHC-ligated Pd(ii) metal complexes in high yields. Further treatment of the latter complexes with tBuOK induced a deprotonation of the carbon atom adjacent to the phosphonium moiety and the formation of the corresponding C,C-chelating NHC-phosphonium ylide Pd(ii) complexes...
September 28, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
Katharina Geißler, Robby Markwart, Robert Pascal Requardt, Cynthia Weigel, Katja Schubert, André Scherag, Ignacio Rubio, Orlando Guntinas-Lichius
The palatine tonsils, localized in the oropharynx, are easily accessible secondary lymphoid tissue in humans. Inflammation of the palatine tonsils, local and chronic in case of chronic tonsillitis (CT) or acute in the presence of a peritonsillar abscess (PTA), ranks among the most common diseases in otolaryngology. However, the functionality of tonsillar immune cells, notably T-cells, in the context of these immune pathologies is poorly understood. We have examined the functional status of human tonsillar T-cells in CT and compared it to the acute inflammatory setting of a PTA...
2017: PloS One
Fred S Sarfo, Sheila Adamu, Dominic Awuah, Bruce Ovbiagele
BACKGROUND: The rapid advancement in telecommunications on the African continent has opened up avenues for improving medical care to underserved populations. Although the greatest burden of neurological disorders is borne by Low-and-Middle Income Countries (LMICs) including sub-Saharan Africa (SSA), there is a profound paucity of neurologists to serve the population. Telemedicine presents a promising avenue for effective mobilization and utilization of the few neurologists in Africa. OBJECTIVE: To systematically review the published literature on the use of telemedicine for improved care and outcomes for patients with neurological disorders in SSA...
September 15, 2017: Journal of the Neurological Sciences
Yuming Zou, Ziteng Zhang, Yangang Liu, Denghui Liu, Weidong Xu
BACKGROUND: Several studies investigated the relationship between programmed cell death 1 (PDCD1) gene polymorphisms and rheumatoid arthritis (RA) risk, but the results were controversial. To explore whether PDCD1 gene polymorphisms have an effect on RA risk, we conducted this meta-analysis to investigate the relationships between PDCD1 polymorphisms (rs36084323 [PD-1.1 G/A], rs11568821 [PD-1.3 G/A] and rs2227981 [PD-1.5 C/T]) and RA risk under 4 genetic models. METHODS: PubMed, EMBASE, Web of Science, Cochrane Library China National Knowledge Infrastructure (CNKI), and Chinese Biomedical Literature Database (CBLM) were systematically searched for all eligible case-control studies...
September 2017: Medicine (Baltimore)
Yoshikuni Mizuno, Nobutaka Hattori, Tomoyoshi Kondo, Masahiro Nomoto, Hideki Origasa, Ryosuke Takahashi, Mitsutoshi Yamamoto, Nobuo Yanagisawa
BACKGROUND: In Japan, selegiline has been approved for combination therapy with levodopa for Parkinson disease (PD). We conducted a trial of selegiline monotherapy for early PD. METHODS: In this 12-week controlled phase III trial, a total of 292 subjects were randomized to receive placebo (n = 146) (full analysis set 140) or selegiline (n = 146) (full analysis set 139). The primary outcome measure was the change in the Unified Parkinson Disease Rating Scale part I + II + III total score from baseline to the final visit...
September 2017: Clinical Neuropharmacology
Shnehal Patel, Oluwadamilola Ojo, Gencer Genc, Srivadee Oravivattanakul, Yang Huo, Tanaporn Rasameesoraj, Lu Wang, James Bena, Michelle Drerup, Nancy Foldvary-Schaefer, Anwar Ahmed, Hubert H Fernandez
BACKGROUND: Parkinson disease (PD) is associated with a high prevalence of insomnia, affecting up to 88% of patients. Pharmacotherapy studies in the literature addressing insomnia in PD reveal disappointing and inconsistent results. Cognitive behavioral therapy (CBT) is a novel treatment option with durable effects shown in primary insomnia. However, the lack of accessibility and expense can be limiting. For these reasons, computerized CBT for insomnia (CCBT-I) has been developed. The CCBT-I program is a 6-week web-based course consisting of daily "lessons" providing learnable skills and appropriate recommendations to help patients improve their sleep habits and patterns...
2017: Journal of Clinical Movement Disorders
Tina Stark, Tobias Lieblein, Maximilian Pohland, Elisabeth Kalden, Petra Freund, René Zangl, Rekha Grewal, Mike Heilemann, Gunter P Eckert, Nina Morgner, Michael W Göbel
The peptide sequence KLVFF resembles the hydrophobic core of the Aβ peptide known to form amyloid plaques in Alzheimer's disease. Starting from its retro-inverso peptide, we have synthesized three generations of peptidomimetics. Step by step natural amino acids have been replaced by aromatic building blocks accessible from the Pd-catalyzed Catellani reaction. The final compound 18 is stable against proteolytic decay and largely prevents the aggregation of Aβ1-42 over extended periods of time. The activity of the new inhibitors was tested first by fluorescence correlation spectroscopy...
September 12, 2017: Biochemistry
Robert D J Froese, Christopher Lombardi, Matthew Pompeo, Richard P Rucker, Michael G Organ
Over the past decade, the use of Pd-NHC complexes in cross-coupling applications has blossomed, and reactions that were either not previously possible or possible only under very forcing conditions (e.g., > 100 °C, strong base) are now feasible under mild conditions (e.g., room temperature, weak base). Access to tools such as computational chemistry has facilitated a much greater mechanistic understanding of catalytic cycles, which has enabled the design of new NHC ligands and accelerated advances in cross-coupling...
August 24, 2017: Accounts of Chemical Research
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