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https://www.readbyqxmd.com/read/29148749/glycosyl-cross-coupling-of-anomeric-nucleophiles-scope-mechanism-and-applications-in-the-synthesis-of-aryl-c-glycosides
#1
Feng Zhu, Jacob Rodriguez, Tianyi Yang, Ilia Kevlishvili, Eric Miller, Duk Yi, Sloane O'Neill, Michael Rourke, Peng Liu, Maciej A Walczak
Stereoselective manipulations at the C1 anomeric position of saccharides are one of the central goals of preparative carbohydrate chemistry. Historically, the majority of reactions forming a bond with anomeric carbon has focused on reactions of nucleophiles with saccharide donors equipped with a leaving group. Here, we describe a novel approach to stereoselective synthesis of C-aryl glycosides capitalizing on the highly stereospecific reaction of anomeric nucleophiles. First, methods for the preparation of anomeric stannanes have been developed and optimized to afford both anomers of common saccharides in high anomeric selectivities...
November 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29148599/hierarchical-porous-phenolic-resin-and-its-supported-pd-catalyst-for-suzuki-miyaura-reactions-in-water-medium
#2
Gaoyang Deng, Zhonggang Wang
The motivation of this work is to build micro and mesopores within phenolic resins to extend their applications to the heterogeneous catalysis field. For this purpose, porous hyper-cross-linked phenolic resin (PFN-P) with Brunauer-Emmett-Teller (BET) surface area of 775 m(2) g(-1) is synthesized through one-step polycondensation from tri(4-formylphenyl)phosphine and 2,5-dihydroxy-1,4-benzoquinone, which simultaneously contains abundant hydroxyl and triphenylphosphine moieties in the network. The resultant palladium-coordinated Pd@PFN-P possesses hierarchical porous structure with pore sizes ranging from 1...
November 17, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29145036/liver-immunotolerance-and-hepatocellular-carcinoma-patho-physiological-mechanisms-and-therapeutic-perspectives
#3
REVIEW
Gaël S Roth, Thomas Decaens
At the moment of the diagnosis of hepatocellular carcinoma (HCC), 70% of patients have only access to palliative treatments, with very few therapeutic options. Liver immunology is very specific, and liver immunotolerance is particularly developed because of the constant and massive influx of antigens. Deregulation of hepatic immunotolerance is implicated in chronic liver diseases development and particularly in liver carcinogenesis. For these reasons, HCC may be an excellent candidate for anticancer immunotherapies such as immune checkpoint inhibitors targeting CTLA-4 and PD-L1/PD-1...
November 13, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29135584/concomitant-medication-polypharmacy-interactions-and-imperfect-adherence-are-common-in-australian-adults-on-suppressive-art
#4
Krista J Siefried, Limin Mao, Lucette A Cysique, John Rule, Michelle L Giles, Don E Smith, James Mcmahon, Tim R Read, Catriona Ooi, Ban K Tee, Mark Bloch, John de Wit, Andrew Carr
OBJECTIVES: We quantified concomitant medication (CM) polypharmacy, pharmacokinetic (PK) and pharmacodynamic (PD) interactions, adverse effects and adherence in Australian adults on effective ART. DESIGN: Cross-sectional. METHODS: Patients recruited into a nation-wide cohort and assessed for prevalence and type of CM (including polypharmacy, defined as ≥5 CMs), PK or PD interactions, potential CM adverse effects and CM adherence. Factors associated with CM polypharmacy and with imperfect adherence were identified using multivariable logistic regression...
November 10, 2017: AIDS
https://www.readbyqxmd.com/read/29135534/the-multiple-faces-of-programmed-cell-death-ligand-1-expression-in-malignant-and-nonmalignant-cells
#5
Edwin R Parra, Pamela Villalobos, Jaime Rodriguez-Canales
Preliminary data suggest that tumor expression of programmed cell death ligand 1 (PD-L1) protein in human cancers, as determined by immunohistochemistry in formalin-fixed, paraffin-embedded tissue samples, may predict clinical response to anti-PD-1/PD-L1 therapy. PD-L1 is not a specific tumor marker and its expression is also observed in various nonmalignant cells, such as macrophages and lymphocytes, causing confusion in immunohistochemistry analysis when these inflammatory cells are overlapping with tumors cells...
November 13, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29134811/synthetic-utility-of-arylmethylsulfones-annulative-%C3%AF-extension-of-aromatics-and-hetero-aromatics-involving-pd-0-catalyzed-heck-coupling-reactions
#6
Elumalai Sankar, Potharaju Raju, Jayachandran Karunakaran, Arasambattu Kannan Mohanakrishnan
A straightforward and general method for synthesis of annulated thiophene, dibenzothiophene and carbazoles analogues have been achieved involving alkylation of 2-bromo-1-(phenylsulfonylmethyl)arene/heteroarene with arylmethylbromides/heteroarylmethylbromides using t-BuOK as a base in DMF followed by Pd(0)-mediated intramolecular Heck coupling in the presence of K2CO3 in DMF at 80-140 degrees C. The attractive feature of this protocol is that a wide variety of π-conjugated heterocycles could be readily accessed by an appropriate choice of arylmethyl sulfones and benzylic bromides...
November 14, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29123006/outcomes-of-simultaneous-peritoneal-dialysis-and-arteriovenous-fistula-placement-in-end-stage-renal-disease-patients
#7
Nosratollah Nezakatgoo, Albert Ndzengue, Manhunath Ramaiah, Elvira O Gosmanova
Peritoneal dialysis (PD) interruption requiring hemodialysis (HD) is not uncommon and its frequently abrupt nature prevents timely creation of permanent HD access and avoidance of central venous catheters (CVC). We retrospectively studied a cohort of 24 end-stage renal disease (ESRD) patients (mean age 50.7 years, 83.3% African-Americans, 58.3% females, time on dialysis interquartile range [IQR] 0 - 65 days) who had simultaneous PD catheter insertion and backup arteriovenous fistula (AVF) creation between January 1, 2012, and December 31, 2013...
November 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/29118576/psychosocial-therapy-for-parkinson-s-related-dementia-intervention-development
#8
Sheree A McCormick, Kathryn R McDonald, Sabina Vatter, Vasiliki Orgeta, Ellen Poliakoff, Sarah J Smith, Iracema Leroi
Background: Group-based psychosocial therapy, such as group Cognitive Stimulation Therapy, improves cognition and quality of life in people living with dementia. Neuropsychiatric symptoms and restricted mobility are common complications for people with Parkinson's-related dementia (PRD) and may limit access to, and participation in, group activities. This study describes the development of a condition-specific, home-based psychosocial therapy for people with PRD ready to be trialled in a clinical population...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29116769/enantioselective-palladium-catalyzed-intramolecular-%C3%AE-arylative-desymmetrization-of-1-3-diketones
#9
Chendan Zhu, Dingyi Wang, Yue Zhao, Wei-Yin Sun, Zhuangzhi Shi
An efficient enantioselective protocol has been reported to build highly oxygenated and densely substituted bicyclo[m.n.1] skeletons through intramolecular asymmetric α-arylative desymmetrization of 1,3-diketones. Employing Pd catalyst and FOXAP ligand, various bicyclo[m.n.1] skeleton with different size can be accessed with high enantio- and diastereoselectivities. Utilizing the present method as a key step, formal asymmetric total synthesis of the (-)-parvifoline has been demonstrated.
November 14, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29105973/ligand-controlled-regiodivergent-c-h-alkenylation-of-pyrazoles-and-its-application-to-the-synthesis-of-indazoles
#10
Hyun Tae Kim, Hyeri Ha, Geunhee Kang, Og Soon Kim, Ho Ryu, Abul Kalam Biswas, Sang Min Lim, Mu-Hyun Baik, Jung Min Joo
Regioselective C4-, C5-, and di-alkenylation of pyrazoles was achieved. Electrophilic Pd catalyst generated by TFA and 4,5-diazafluoren-9-one (DAF) led to C4-alkenylation, whereas KOAc and mono-protected amino acid (MPAA) ligand, Ac-Val-OH gave C5-alkenylation. Combining palladium acetate with silver carbonate and pivalic acid, dialkenylation products were formed. Annulation via sequential alkenylation, thermal 6π-electrocyclization, and oxidation gave functionalized indazoles. This comprehensive strategy greatly expanded the range of readily accessible pyrazole and indazole derivatives, enabling useful regiodivergent C-H functionalization of pyrazoles and other heteroaromatic systems...
November 5, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29104810/management-of-psychosis-in-parkinson-s-disease-emphasizing-clinical-subtypes-and-pathophysiological-mechanisms-of-the-condition
#11
REVIEW
Raquel N Taddei, Seyda Cankaya, Sandeep Dhaliwal, K Ray Chaudhuri
Investigation into neuropsychiatric symptoms in Parkinson's disease (PD) is sparse and current drug development is mainly focused on the motor aspect of PD. The tight association of psychosis with an impaired quality of life in PD, together with an important underreporting of this comorbid condition, contributes to its actual insufficient assessment and management. Furthermore, the withdrawal from access to readily available treatment interventions is unacceptable and has an impact on PD prognosis. Despite its impact, to date no standardized guidelines to the adequate management of PD psychosis are available and they are therefore highly needed...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/29093985/trends-in-the-incidence-of-tooth-extraction-due-to-periodontal-disease-results-of-a-12-year-longitudinal-cohort-study-in-south-korea
#12
Jae-Hong Lee, Jin-Young Oh, Jung-Kyu Choi, Yeon-Tae Kim, Ye-Sol Park, Seong-Nyum Jeong, Seong-Ho Choi
Purpose: This study evaluated trends in tooth extraction due to acute and chronic periodontal disease (PD) using data from the National Health Insurance Service-National Sample Cohort for 2002-2013. Methods: A random sample of 1,025,340 individuals was selected as a representative sample of the population, and a database (DB) of diagnostic and prescription codes was followed up for 12 years. We used multivariate logistic regression analysis to assess the incidence of total extraction (TE), extraction due to periodontal disease (EPD), and immediate extraction due to periodontal disease (IEPD) according to sociodemographic factors (sex, age, household income, health status, and area of residence)...
October 2017: Journal of Periodontal & Implant Science
https://www.readbyqxmd.com/read/29093818/the-novel-19g-endobronchial-uss-ebus-needle-samples-processed-as-tissue-core-biopsies-facilitate-pd-l1-and-other-biomarker-testing-in-lung-cancer-specimens-case-report-and-the-view-point-from-the-respiratory-physician-and-the-pathologist
#13
Samantha Herath, Wendy A Cooper
The immunohistochemical expression of Programmed Death Ligand (PD-L1) predicts responses to PD-1/PD-L1 inhibitors in non-small cell lung cancer (NSCLC). PD-L1 testing is currently only recommended on tissue specimens; however, in many patients, cytology samples are the only specimens available. The introduction of the novel 19G "core-biopsy" needle has revolutionized the utility of endobronchial USS-guided biopsy (EBUS) by providing solid tissue "microbiopsies" rather than traditional liquid cytology samples...
November 2017: Respirology Case Reports
https://www.readbyqxmd.com/read/29089601/selective-catalytic-hydrogenation-of-the-n-acyl-and-uridyl-double-bonds-in-the-tunicamycin-family-of-protein-n-glycosylation-inhibitors
#14
Neil Pj Price, Michael A Jackson, Karl E Vermillion, Judith A Blackburn, Jiakun Li, Biao Yu
Tunicamycin is a Streptomyces-derived inhibitor of eukaryotic protein N-glycosylation and bacterial cell wall biosynthesis, and is a potent and general toxin by these biological mechanisms. The antibacterial activity is dependent in part upon a π-π stacking interaction between the tunicamycin uridyl group and a specific Phe residue within MraY, a tunicamycin-binding protein in bacteria. We have previously shown that reducing the tunicamycin uridyl group to 5,6-dihydrouridyl (DHU) significantly lowers its eukaryotic toxicity, potentially by disrupting the π-stacking with the active site Phe...
November 1, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/29082984/aerobic-oxidative-%C3%AE-arylation-of-furans-with-boronic-acids-via-pd-ii-catalyzed-c-c-bond-cleavage-of-primary-furfuryl-alcohols-sustainable-access-to-arylfurans
#15
Guanghao Huang, Lin Lu, Huanfeng Jiang, Biaolin Yin
Aerobic oxidative α-arylation of furans with boronic acids via Pd(ii)-catalyzed C-C bond cleavage of primary furfuryl alcohols provides sustainable access to arylfurans. This protocol opens a new avenue for the transformation of readily available furans into other useful compounds.
October 30, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29082407/facile-construction-of-fascinating-trimetallic-pdauag-nanocages-with-exceptional-ethylene-glycol-and-glycerol-oxidation-activity
#16
Hui Xu, Jin Wang, Bo Yan, Shumin Li, Caiqin Wang, Yukihide Shiraishi, Ping Yang, Yukou Du
Highly open metallic nanocages represent a novel class of nanostructures for advanced catalytic applications in direct liquid fuels cells due to their specific capability of providing easy access to reactants in both internal and external active sites and also desirable electronic structures for the adsorption of molecules, which render superior catalytic performances. However, to date, the rational design of trimetallic nanocages with tunable compositions remains a challenge. Herein, we demonstrate a facile method combining seed mediated and galvanic replacement for the preparation of unique trimetallic Pd-Au-Ag nanocages catalysts with tunable compositions...
November 9, 2017: Nanoscale
https://www.readbyqxmd.com/read/29071808/controllable-activation-of-pd-g3-palladacycle-precatalyst-in-the-presence-of-thiosugars-rapid-access-to-1-aminobiphenyl-thioglycoside-atropoisomers-at-room-temperature
#17
Samir Messaoudi, Riyadh Ahmed Atto Al-Shuaeeb, Mouad Alami, Camille Dejean
A controllable method for the functionalization of XantPhos Pd-G3 precatalyst with thiosugars and thiols has been established. Under mild and operationally simple reaction conditions through just mixing of precatalyst and thiosugars (α- or β-mono-, di- and poly-thiosugar derivatives) in water at 25 °C for 20 min, a series of 1-aminobiphenyl thioglycosides that are difficult to synthesize by classical methods, has been synthesized in very high yields.
October 26, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29071698/-movement-disorders-units-and-management-of-motor-fluctuations-in-advanced-parkinson-s-disease
#18
O de Fabregues, A Gironell, D Rossello-Jimenez, E Regueras
INTRODUCTION: Advanced Parkinson's disease (PD) entails complications, such as motor fluctuations. In Spain, medical attention for such cases is often provided in movement disorder units (MDU). AIM: To gain further knowledge of the diagnostic resources and therapeutic approach of MDU. SUBJECTS AND METHODS: A descriptive cross-sectional study was conducted. The researchers designed an on-line questionnaire, addressed to neurologists from MDUs, containing 48 questions about the resources they have available, the number of patients with PD and motor fluctuations that have been attended to, as well as the therapeutic approach, according to the Hoehn and Yahr (HY) scale...
November 1, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/29064720/controllable-stereoselective-synthesis-of-z-and-e-homoallylic-alcohols-using-a-palladium-catalyzed-three-component-reaction
#19
Yoshikazu Horino, Miki Sugata, Itaru Mutsuura, Keisuke Tomohara, Hitoshi Abe
Diastereoselective synthesis of (Z)- and (E)-homoallylic alcohols using a Pd-catalyzed three-component reaction of 3-(pinacolatoboryl)allyl benzoates, aldehydes, and aryl stannanes was developed, which provides an alternative method for the allylboration of aldehydes using α,γ-diaryl-substituted allylboronates. Both sets of reaction conditions enable access to either (Z)- or (E)-homoallylic alcohols with good to high alkene stereocontrol. The present method showed good functional group compatibility and generality...
October 24, 2017: Organic Letters
https://www.readbyqxmd.com/read/29044274/pd-catalysed-suzuki-coupling-of-%C3%AE-bromoethenylphosphonates-with-organotrifluoroborates-a-general-protocol-for-the-synthesis-of-terminal-%C3%AE-substituted-vinylphosphonates
#20
Li Zhang, Yewen Fang, Xiaoping Jin, Housan Xu, Ruifeng Li, Hao Wu, Bin Chen, Yiming Zhu, Yi Yang, Zongming Tian
A general and robust protocol for the synthesis of terminal α-substituted vinylphosphonates via Suzuki coupling of α-bromovinylphosphonates with organotrifluoroborates has been successfully developed. This method features a broad substrate scope, great functional group compatibilities, and easy scale-up ability. In addition to easy access of nucleophiles, a straightforward synthesis of electrophiles was also realized with diethyl α-bromoethenylphosphonate as the starting material. With a combination of Pd2(dba)3/SPhos as the catalyst, a range of α-alkyl, aryl, heteroaryl, and alkynyl substituted ethenylphosphonates could be nicely accessed under mild conditions...
October 31, 2017: Organic & Biomolecular Chemistry
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