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https://www.readbyqxmd.com/read/27911463/vascular-access-types-in-patients-starting-hemodialysis-after-failed-kidney-transplant-does-close-nephrology-follow-up-matter
#1
Naveed Ul Haq, Mohamed Said Abdelsalam, Mohammed Mahdi Althaf, Abdulrahman Ali Khormi, Hassan Al Harbi, Bader Alshamsan, Mamdouh Nasser Albaqumi, Dieter Clemens Broering, Lutfi Alkorbi, Hassan Ali Aleid
BACKGROUND: Native arteriovenous fistulae (AVFs) are preferred while central venous catheters (CVCs) are least suitable vascular access (VA) in patients requiring hemodialysis (HD). Unfortunately, around 80% of patients start HD with CVCs. Late referral to nephrologist is thought to be a factor responsible for this. We retrospectively analyzed the types of VA at HD initiation in renal transplant recipients followed by nephrologists with failed transplant. If early referral to nephrologist improves AVF use, these patients should have higher prevalence of AVF at HD initiation...
November 28, 2016: Journal of Vascular Access
https://www.readbyqxmd.com/read/27903852/topical-honey-in-the-management-of-pediatric-peritoneal-dialysis-exit-sites
#2
Thomas A Forbes, Loren Shaw, Catherine Quinlan
International guidelines in peritoneal dialysis (PD) advocate for regular application of topical mupirocin in chronic PD exit-site care. A strong evidence base links this treatment to reduced rates of exit-site infections and peritonitis. However, emerging reports of increasing mupirocin resistance and gram-negative infections are threatening the long-term viability of topical antibiotic ointments as a prophylactic treatment. Medical grade honey has multiple proven antibacterial and wound healing properties...
November 2016: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/27896268/challenges-for-relative-effectiveness-assessment-and-early-access-of-cancer-immunotherapies-in-europe
#3
Mira Pavlovic
Clinical endpoints relevant for relative effectiveness assessment (REA) reflect how patients feel, function, or survive. Outcome data requested by health technology assessment (HTA) bodies in Europe to support reimbursement of an anticancer drug are based on final endpoints coming from completed comparative phase 3 trials; overall survival improvement is the preferred criterion for the demonstration of the patient benefit in this field. Recent arrival of new treatments that target identified functional genetic mutations ("targeted therapies") or PD-1/PD-L1,2 axis ("immunotherapies") and their combinations have profoundly changed treatment strategies in cancers as they considerably improve patient survival, but also raise new challenges in REA and decision-making process in Europe as compared to the REA of "classical" chemotherapies...
2016: Frontiers in Medicine
https://www.readbyqxmd.com/read/27894187/endoscopic-ultrasound-guided-pancreatobiliary-endoscopy-in-surgically-altered-anatomy
#4
REVIEW
Pichamol Jirapinyo, Linda S Lee
Endoscopic retrograde cholangiopancreatography (ERCP) has become the mainstay of therapy for pancreatobiliary diseases. While ERCP is safe and highly effective in the general population, the procedure remains challenging or impossible in patients with surgically altered anatomy (SAA). Endoscopic ultrasound (EUS) allows transmural access to the bile or pancreatic duct (PD) prior to ductal drainage using ERCP-based techniques. Also known as endosonography-guided cholangiopancreatography (ESCP), the procedure provides multiple advantages over overtube-assisted enteroscopy ERCP or percutaneous or surgical approaches...
November 2016: Clinical Endoscopy
https://www.readbyqxmd.com/read/27893564/instrumented-test-of-sensory-integration-for-balance-a-validation-study
#5
Lynn Freeman, Geetanjali Gera, Fay B Horak, Mary T Blackinton, Mark Besch, Laurie King
BACKGROUND AND PURPOSE: Abnormal postural sway is associated with an increase in risk of falls but is difficult for clinicians to accurately quantify without access to laboratory equipment. Instrumenting clinical outcome measures using body-worn movement monitors is a low-cost alternative. This is the first study to compare the modified Clinical Test of Sensory Integration for Balance (i-mCTSIB) to the laboratory test of the Sensory Organization Test (SOT) with dynamic posturography in a group of participants with Parkinson's disease (PD) and subtle balance limitations...
November 23, 2016: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/27892591/pd-mediated-cross-coupling-of-c-17-lithiated-androst-16-en-3-ol-access-to-functionalized-arylated-steroid-derivatives
#6
Vanessa Koch, Stefan Bräse
Herein, we report on Pd-mediated cross-coupling of vinyllithium steroids and aryl bromides to introduce various substituted aryls at C-17 of steroidal frameworks based on the structure of epi-androsterone. Compared to other C-C cross-couplings, this method turned out to be an easy and competitive access to biologically interesting C-17 modified steroids.
November 28, 2016: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/27886320/a-palladium-and-gold-catalytic-system-enables-direct-access-to-o-and-s-linked-non-natural-glyco-conjugates
#7
Min Ho Jeon, Bijoy P Mathew, Malleswara Rao Kuram, Kyungjae Myung, Sung You Hong
Here we report a straightforward cross-coupling method for the synthesis of non-natural glycoamino acids from alkyne-bearing monosaccharides and p-iodophenylalanine. Pd/Au-catalyzed Sonogashira coupling is tolerant to both O- and S-glycosides without any epimerization. In addition, no racemization of the amino acid was observed allowing direct access to the homogeneous glyco-conjugate in a single step. Notably, this Pd/Au catalytic system presents enhanced catalytic activity than conventional Pd/Cu and Pd-only platforms, and it further enables the convergent synthesis of glycodipeptides...
November 25, 2016: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/27885736/palladium-nanoparticles-encapsulated-in-hollow-titanosilicate-spheres-as-an-ideal-nanoreactor-for-one-pot-oxidation
#8
Yasutaka Kuwahara, Takahiro Ando, Hiroto Kango, Hiromi Yamashita
One-pot reaction involving Pd-catalyzed H2 O2 production from H2 and O2 and Ti-catalyzed successive oxidation with H2 O2 in a single reaction vessel is an alluring strategy for the synthesis of targeted chemicals in terms of sustainability and economic competitiveness. In this study, a yolk-shell nanostructured catalyst, consisting of Pd nanoparticles (NPs) with core diameter ca. 4.0 nm and a porous titanosilicate shell of ca. 15 nm thickness, was fabricated by using an oil-in-water (O/W) microemulsion-based interfacial self-assembly approach...
November 25, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27879959/balance-versus-resistance-training-on-postural-control-in-patients-with-parkinson-s-disease-a-randomised-controlled-trial
#9
Suhaila M Santos, Rubens A Da Silva, Marcelle B Terra, Isabela A Almeida, Lucio B De Melo, Henrique B Ferraz
BACKGROUND: Evidences have shown that physiotherapy programs may improve the balance of individuals with Parkinson's disease (PD); although it is not clear which specific exercise program is better. AIM: Compare the effectiveness of balance versus resistance training on postural control measures in PD patients. DESIGN: Randomised controlled trial. SETTING: The study was conducted in a physiotherapy outpatient clinic of a university hospital...
November 23, 2016: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27873302/ultrasonographic-findings-can-identify-pseudoprogression-under-nivolumab-therapy
#10
K Imafuku, H Hata, S Kitamura, T Yanagi, H Shimizu
'Pseudoprogression' is often seen in patients with melanomas who are treated with immune-checkpoint inhibitors such as nivolumab or ipilimumab. We sometimes evaluate metastatic lesions by imaging tests such as CT or PET-CT. 'Pseudoprogression' usually occurs upon the initial administration, which may make it difficult for the physician to determine the disease condition. In our two cases of metastatic melanoma treated with nivolumab (anti-PD-1 antibody), we examined the ultrasonography (US) of target lesions that could be accessed from the body surface, such as those of the regional lymph node or subcutaneous metastasis...
November 22, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27870257/higher-levels-of-apomorphine-and-rotigotine-prescribing-reduce-overall-secondary-healthcare-costs-in-parkinson-s-disease
#11
A H Heald, M Livingston, M Stedman, Z Wyrko
BACKGROUND: Parkinson's disease (PD) affects around 100,000 people in England. A number of non-oral therapies can improve both the quality of life and reduce patient needs for health and social care. However, these can be relatively expensive at £2000-£10,000 per year per patient. Our aim was to examine how prescribing of these agents relates to secondary care costs. METHODS: Using practice level primary care prescribing data and hospital episode statistical data in England, we investigated the relation between general practitioner prescriptions of apomorphine injections/rotigotine patches and the secondary care costs accrued for their diagnosed PD patients for 2011-2014...
November 2016: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/27862327/an-order-in-lewy-body-disorders-retrograde-degeneration-in-hyperbranching-axons-as-a-fundamental-structural-template-accounting-for-focal-multifocal-lewy-body-disease
#12
REVIEW
Toshiki Uchihara 内原 俊記
Initial clinical recognition of "paralysis agitans" by James Parkinson was expanded by Jean-Martin Charcot, who recognized additional clinical findings of his own, such as slowness (distinct from paralysis), rigidity (distinct from spasticity) and characteristic countenance. Charcot assembled these findings under the umbrella of "Parkinson disease (PD)". This purely clinical concept was so prescient and penetrating that subsequent neuropathological and biochemical evidences were ordered along this axis to establish the nigra-central trinity of PD (dopamine depletion, nigral lesion with Lewy bodies: LBs)...
November 14, 2016: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/27862198/synthesis-and-selective-2-h-13-c-and-15-n-labeling-of-the-tau-protein-binder-thk-523
#13
Karoline T Neumann, Anders T Lindhardt, Benny Bang-Andersen, Troels Skrydstrup
A new synthetic route to the Tau binder, THK-523, is disclosed herein, which can easily be adapted to (13) C- and D-isotope labeling. The synthesis proceeds via two key reactions, namely, a Pd-catalyzed carbonylative Sonogashira coupling and a reductive ring-closing step with hydrogen or deuterium gas. By carrying out these reactions in a 2-chamber reactor we reported previously, ex situ-generated carbon monoxide and hydrogen/deuterium can be applied in stoichiometric quantities, thereby facilitating isotope labeling of this Tau-binding compound...
November 13, 2016: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/27853827/increased-pd-l1-and-t-cell-infiltration-in-the-presence-of-hla-class-i-expression-in-metastatic-high-grade-osteosarcoma-a-rationale-for-t-cell-based-immunotherapy
#14
Yayan T Sundara, Marie Kostine, Arjen H G Cleven, Judith V M G Bovée, Marco W Schilham, Anne-Marie Cleton-Jansen
INTRODUCTION: Immunotherapy may be an excellent choice for treating osteosarcoma given its exceptionally high genomic instability, potentially generating neoantigens. In this study, we aim to investigate the HLA class I expression, PD-L1 and tumour-infiltrating lymphocytes in primary osteosarcomas and relapses/metastases, as well as their changes during disease progression. MATERIALS AND METHODS: Tumour samples from multiple stages of the disease (pretreatment biopsies, surgical resections of primary osteosarcomas, relapses and metastases) were collected and stained for HLA-A (HCA2), HLA-B/C (HC10), β2-microglobulin and PD-L1 using immunohistochemistry on whole sections...
November 16, 2016: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/27845400/scalable-synthesis-of-ag-networks-with-optimized-sub-monolayer-au-pd-nanoparticle-covering-for-highly-enhanced-sers-detection-and-catalysis
#15
Tianyu Li, Sascha Vongehr, Shaochun Tang, Yuming Dai, Xiao Huang, Xiangkang Meng
Highly porous tri-metallic AgxAuyPdz networks with a sub-monolayer bimetallic Au-Pd nanoparticle coating were synthesized via a designed galvanic replacement reaction of Ag nanosponges suspended in mixed solutions of HAuCl4 and K2PdCl4. The resulting networks' ligaments have a rough surface with bimetallic nanoparticles and nanopores due to removal of Ag. The surface morphology and composition are adjustable by the temperature and mixed solutions' concentration. Very low combined Au and Pd atomic percentage (1-x) where x is atomic percentage of Ag leads to sub-monolayer nanoparticle coverings allowing a large number of active boundaries, nanopores, and metal-metal interfaces to be accessible...
November 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27844086/investigating-the-electronic-structure-of-a-supported-metal-nanoparticle-pd-in-sicn
#16
Tobias Schmidt, Rodrigo Q Albuquerque, Rhett Kempe, Stephan Kümmel
We investigate the electronic structure of a Palladium nanoparticle that is partially embedded in a matrix of silicon carbonitride. From classical molecular dynamics simulations we first obtain a representative atomic structure. This geometry then serves as input to density-functional theory calculations that allow us to access the electronic structure of the combined system of particle and matrix. In order to make the computations feasible, we devise a subsystem strategy for calculating the relevant electronic properties...
November 15, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27842458/suppression-of-canine-dendritic-cell-activation-maturation-and-inflammatory-cytokine-release-by-mesenchymal-stem-cells-occurs-via-multiple-distinct-biochemical-pathways
#17
William Henry Wheat, Lyndah Chow, Jade N Kurihara, Daniel P Regan, Jonathan W Coy, Tracy L Webb, Steven W Dow
Mesenchymal stem cells (MSC) represent a readily accessible source of cells with potent immune modulatory activity. MSC can suppress ongoing inflammatory responses by suppressing T cell function, while fewer studies have examined the impact of MSC on dendritic cell function. The dog spontaneous disease model represents an important animal model with which to evaluate the safety and effectiveness of cellular therapy with MSC. This study evaluated the effects of canine MSC on the activation and maturation of canine monocyte-derived dendritic cells (DC), as well as mechanisms underlying these effects...
November 14, 2016: Stem Cells and Development
https://www.readbyqxmd.com/read/27836714/abnormal-nociceptive-processing-occurs-centrally-and-not-peripherally-in-pain-free-parkinson-disease-patients-a-study-with-laser-evoked-potentials
#18
Sandro Zambito-Marsala, Roberto Erro, Ruggero Bacchin, Annalisa Fornasier, Federico Fabris, Cecilia Lo Cascio, Franco Ferracci, Francesca Morgante, Michele Tinazzi
BACKGROUND: Several studies documented abnormal nociceptive processing in PD patients. Pain central pathways are accessible by laser-evoked potentials (LEPs). LEPs recording show a N2/P2 complex mostly generated by the anterior cingulate cortex, preceded by an earlier negative component (N1), originating from the opercular cortex. Previous work demonstrated N2/P2 amplitude reduction in PD patients and suggested a centrally-acting pathomechanism for the genesis of pain. However, since a peripheral deafferentation has been recently demonstrated in PD, it is not clear if such LEP abnormalities reflect a mechanism acting centrally or not...
October 24, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27834777/the-road-less-traveled-alternative-pathways-for-action-verb-processing-in-parkinson-s-disease
#19
Sofía Abrevaya, Lucas Sedeño, Sol Fitipaldi, David Pineda, Francisco Lopera, Omar Buritica, Andrés Villegas, Catalina Bustamante, Diana Gomez, Natalia Trujillo, Ricardo Pautassi, Agustín Ibáñez, Adolfo M García
Action verbs are critically embodied in motor brain networks. In Parkinson's disease (PD), damage to the latter compromises access to such words. However, patients are not fully incapable of processing them, as their performance is far from floor level. Here we tested the hypothesis that action-verb processing in PD may rely on alternative disembodied semantic circuits. Seventeen PD patients and 15 healthy controls listened to action verbs and nouns during functional MRI scanning. Using cluster-mass analysis with a permutation test, we assessed task-related functional connectivity considering seeds differentially engaged by action and non-action words (namely, putamen and M1 versus posterior superior temporal lobe, respectively)...
November 9, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27829927/regiocontroled-pd-catalysed-c5-arylation-of-3-substituted-thiophene-derivatives-using-a-bromo-substituent-as-blocking-group
#20
Mariem Brahim, Hamed Ben Ammar, Jean-François Soulé, Henri Doucet
The use of a bromo-substituent as blocking group at the C2-position of 3-substituted thiophenes allows the regioselective introduction of aryl substituents at C5-position via Pd-catalysed direct arylation. With 1 mol % of a phosphine-free Pd catalyst, KOAc as the base and DMA as the solvent and various electron-deficient aryl bromides as aryl sources, C5-(hetero)arylated thiophenes were synthesized in moderate to high yields, without cleavage of the thienyl C-Br bond. Moreover, sequential direct thienyl C5-arylation followed by Pd-catalysed direct arylation or Suzuki coupling at the C2-position allows to prepare 2,5-di(hetero)arylated thiophenes bearing two different (hetero)aryl units in only two steps...
2016: Beilstein Journal of Organic Chemistry
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