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https://www.readbyqxmd.com/read/28921952/nano-air-seeds-trapped-in-mesoporous-janus-nanoparticles-facilitate-cavitation-and-enhance-ultrasound-imaging
#1
Konstantin Tamarov, Andrey Sviridov, Wujun Xu, Markus Malo, Valery Andreev, Victor Yu Timoshenko, Vesa-Pekka Lehto
The current contrast agents utilized in ultrasound (US) imaging are based on microbubbles which, however, suffer from a short lifetime in the systemic circulation. The present study introduces a new type of contrast agents for US imaging based on bioresorbable Janus nanoparticles (NPs) that are able to generate microbubbles in situ under US radiation for extended time. The Janus NPs were fabricated from porous silicon (PSi) that was modified via a nanostopper technique. The technique was exploited to prepare PSi NPs which had hydrophobic pore walls (inner face) while the external surfaces of the NPs (outer face) were hydrophilic...
September 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28921550/sugars-from-woody-tissue-photosynthesis-reduce-xylem-vulnerability-to-cavitation
#2
Niels J F De Baerdemaeker, Roberto Luis Salomón, Linus De Roo, Kathy Steppe
Reassimilation of internal CO2 via woody tissue photosynthesis has a substantial effect on tree carbon income and wood production. However, little is known about its role in xylem vulnerability to cavitation and its implications in drought-driven tree mortality. Young trees of Populus nigra were subjected to light exclusion at the branch and stem levels. After 40 d, measurements of xylem water potential, diameter variation and acoustic emission (AE) were performed in detached branches to obtain acoustic vulnerability curves to cavitation following bench-top dehydration...
September 18, 2017: New Phytologist
https://www.readbyqxmd.com/read/28913435/iba57-mutations-abrogate-iron-sulfur-cluster-assembly-leading-to-cavitating-leukoencephalopathy
#3
Akihiko Ishiyama, Chika Sakai, Yuichi Matsushima, Satoru Noguchi, Satomi Mitsuhashi, Yukari Endo, Yukiko K Hayashi, Yoshiaki Saito, Eiji Nakagawa, Hirofumi Komaki, Kenji Sugai, Masayuki Sasaki, Noriko Sato, Ikuya Nonaka, Yu-Ichi Goto, Ichizo Nishino
OBJECTIVE: To determine the molecular factors contributing to progressive cavitating leukoencephalopathy (PCL) to help resolve the underlying genotype-phenotype associations in the mitochondrial iron-sulfur cluster (ISC) assembly system. METHODS: The subjects were 3 patients from 2 families who showed no inconsistencies in either clinical or brain MRI findings as PCL. We used exome sequencing, immunoblotting, and enzyme activity assays to establish a molecular diagnosis and determine the roles of ISC-associated factors in PCL...
October 2017: Neurology. Genetics
https://www.readbyqxmd.com/read/28911990/peri-dome-choroidal-deepening-in-highly-myopic-eyes-with-dome-shaped-maculas
#4
Kyoko Ohno-Matsui, Yuxin Fang, Kengo Uramoto, Kosei Shinohara, Tae Yokoi, Tomoka Ishida, Jost B Jonas
PURPOSE: To determine characteristics of peri-dome choroidal deepening (PDCD) surrounding dome-shaped maculas (DSMs) in highly myopic eyes. DESIGN: Observational case series. METHODS: Applying swept-source optical coherence tomography, we examined the posterior pole of highly myopic eyes with DSMs. RESULTS: The study included 91 highly myopic eyes (67 patients; mean age: 60.0±15.1 years; mean axial length: 30.0±7.4mm) with a mean dome height of the DSM of 232±132 μm...
September 11, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28900624/ultrasound-mediated-microbubbles-destruction-augmented-sonolysis-an-in-vitro-and-in-vivo-study
#5
Hai Cui, Qiong Zhu, Yunhua Gao, Hongmei Xia, Kaibin Tan, Ying He, Zheng Liu, Yali Xu
OBJECTIVE: This study was aimed at exploring ultrasound mediated microbubbles destruction (UMMD) assisted sonolysis in both the in vitro and in vivo clots. METHODS: Therapeutic ultrasound (TUS) and lipid microbubbles (MBs) were used in whole blood clots and divided into the control, TUS group, and TUS + MB group. Thrombolytic rates and microscopy were performed. Color Doppler flow imaging (CDFI) and angiography were performed to evaluate the recanalization rates and flow scores in femoral arterial thrombus (FAT) in rabbits...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28900571/cavitation-sounds-during-cervicothoracic-spinal-manipulation
#6
James Dunning, Firas Mourad, Andrea Zingoni, Raffaele Iorio, Thomas Perreault, Noah Zacharko, César Fernández de Las Peñas, Raymond Butts, Joshua A Cleland
BACKGROUND: No study has previously investigated the side, duration or number of audible cavitation sounds during high-velocity low-amplitude (HVLA) thrust manipulation to the cervicothoracic spine. PURPOSE: The primary purpose was to determine which side of the spine cavitates during cervicothoracic junction (CTJ) HVLA thrust manipulation. Secondary aims were to calculate the average number of cavitations, the duration of cervicothoracic thrust manipulation, and the duration of a single cavitation...
August 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/28898343/-differential-diagnosis-of-bone-marrow-and-lung-granulomas-report-of-one-case
#7
Camila Peña, Andrés Soto, Pablo Villegas
The differential diagnosis of pulmonary tuberculosis and lymphoma with pulmonary infiltration is very difficult, given their similar clinical characteristics. We report a 59 year old female with weight loss, fever, dyspnea and cough of several months of duration. She had a cavitated mass in lung imaging. A positive conventional PCR lead to the diagnosis of tuberculosis, but she had negative smears and cultures for Mycobacterium tuberculosis. The patient did not respond to treatment and her clinical condition worsened...
May 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28892415/susceptibility-of-m-tuberculosis-infected-host-cells-to-phospho-mlkl-driven-necroptosis-is-dependent-on-cell-type-and-presence-of-tnf%C3%AE
#8
Rachel E Butler, Nitya Krishnan, Waldo Garcia-Jimenez, Robert Francis, Abbe Martyn, Tom Mendum, Shaza Felemban, Nicolas Locker, Javier Salguero-Bodes, Brian Robertson, Graham R Stewart
An important feature of Mycobacterium tuberculosis pathogenesis is the ability to control cell death in infected host cells, including inhibition of apoptosis and stimulation of necrosis. Recently an alternative form of programmed cell death, necroptosis, has been described where necrotic cell death is induced by apoptotic stimuli under conditions where apoptotic execution is inhibited. We show for the first time that M. tuberculosis and TNFα synergise to induce necroptosis in murine fibroblasts via RIPK1-dependent mechanisms and characterized by phosphorylation of Ser345 of the MLKL necroptosis death effector...
September 11, 2017: Virulence
https://www.readbyqxmd.com/read/28890612/comparative-evaluation-of-sealing-ability-water-absorption-and-solubility-of-three-temporary-restorative-materials-an-in-vitro-study
#9
A R Prabhakar, N Shantha Rani, Saraswathi V Naik
BACKGROUND: The quality of the coronal seal of root canal filling material is important for periapical health. Absorption of water or saliva by the temporary restorative materials leads to dimensional changes, loss of retention, staining and breaking in margin contours. Hence this study was carried out to evaluate and compare the sealing properties, water absorption and solubility of IRM (intermediate restorative material), Cavit G and GC Caviton. STUDY DESIGN: Experimental, in vitro intergroup randomized control trial...
April 2017: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28888440/current-applications-and-new-opportunities-for-the-thermal-and-non-thermal-processing-technologies-to-generate-berry-product-or-extracts-with-high-nutraceutical-contents
#10
REVIEW
Fuhua Li, Gu Chen, Bin Zhang, Xiong Fu
The demand from consumer for safe and nutritious berry and berry products has promoted the rapid development of non-conventional processing technologies. This review summarizes the recent advances of thermal and non-thermal processing technologies in berry and berry products, including microwave, ohmic heating, high pressure processing, irradiation, dense phase carbon dioxide, ultrasonic processing, pulsed electric field, ozone, membrane processing technologies, cold plasma, and hydrothermodynamic cavitation...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28885852/thermodynamic-anomalies-in-stretched-water
#11
Y Elia Altabet, Rakesh S Singh, Frank H Stillinger, Pablo G Debenedetti
Via molecular dynamics simulations of the TIP4P/2005 water model, we study liquid water's anomalous behavior at large negative pressure produced through isochoric cooling. We find that isochores without a pressure minimum can display "reentrant" behavior whereby a system that cavitates upon cooling can then rehomogenize upon further cooling. This behavior is a consequence of the underlying density maximum along the spinodal, but its actual manifestation in simulations is strongly influenced by finite size effects...
September 8, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28884736/-the-application-of-low-frequency-ultrasound-for-the-comprehensive-treatment-and-rehabilitation-of-the-patients-presenting-with-chronic-endometritis
#12
Yu V Kovaleva
The incidence of chronic endometritis remains rather high despite considerable progress in reproductive medicine including the advent of the new methods for assisted reproduction; the pregnancy rate after the treatment of this condition is still unacceptably low. It implies the necessity of the careful preparation of endometrium for the implantation of the embryo especially in women with a history of unsuccessful outcomes of the IVF treatment. It calls for the development of the efficient therapeutic modalities for the management of chronic endometritis and restoration of the normal reproductive function; their introduction into the therapeutic algorithm remains equally relevant...
2017: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/28881480/hypomineralised-second-primary-molars-prevalence-defect-characteristics-and-relationship-with-dental-caries-in-melbourne-preschool-children
#13
M L Owen, A Ghanim, D Elsby, D J Manton
BACKGROUND: Dental caries and enamel defects (DDE) are prevalent amongst children. The presence of DDEs, especially enamel hypomineralisation, may increase caries experience in those at increased caries-risk. The reported prevalence of hypomineralised second primary molars (HSPM) is 2.7% - 21.8%, although the occurrence in Australian children remains unknown. These HSPM represent a potential predictive factor for molar-incisor hypomineralisation (MIH). METHODS: In total, 623 three to five-year-old children from 30 randomly selected kindergartens participated...
September 7, 2017: Australian Dental Journal
https://www.readbyqxmd.com/read/28877284/caries-progression-in-non-cavitated-fissures-after-infiltrant-application-a-3-year-follow-up-of-a-randomized-controlled-clinical-trial
#14
Camillo Anauate-Netto, Laurindo Borelli, Ricardo Amore, Vinicius DI Hipólito, Paulo Henrique Perlatti D'Alpino
Objectives: To evaluate the efficacy of a conservative treatment to prevent the progression of caries using an infiltrant on non-cavitated pit and fissures. Material and Methods: This controlled clinical trial selected 23 volunteers with clinically and radiographically non-cavitated occlusal caries among patients presenting a "rather low" to "very high" caries risk. Eighty-six teeth were randomly divided into two experimental groups: teeth receiving a commercial pit-and-fissure sealant (Alpha Seal-DFL) and contralateral teeth receiving Icon infiltrant (DMG)...
July 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28873696/enhanced-antimicrobial-effect-of-ultrasound-by-the-food-colorant-erythrosin-b
#15
Luis J Bastarrachea, Martin Walsh, Steven P Wrenn, Rohan V Tikekar
The synergistic combination of the food colorant Erythrosin B (E-B, FD&C 3) (0, 25, and 50μM) and low-frequency ultrasound (20kHz, 0.86-0.90WmL(-1)) was evaluated against Listeria innocua. Although E-B was antibacterial by itself, the inactivation rate significantly increased in a concentration-dependent manner upon exposure to ultrasound and followed a sigmoidal behavior. The enhanced antimicrobial effect of E-B in the presence of ultrasound can be explained in part from a microbubble disappearance study in which it was confirmed that the presence of E-B enhances inertial cavitation, thereby enhancing the antimicrobial effect of ultrasound...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28872138/nitrogen-cavitation-and-differential-centrifugation-allows-for-monitoring-the-distribution-of-peripheral-membrane-proteins-in-cultured-cells
#16
Mo Zhou, Mark R Philips
Cultured cells are useful for studying the subcellular distribution of proteins, including peripheral membrane proteins. Genetically encoded fluorescently tagged proteins have revolutionized the study of subcellular protein distribution. However, it is difficult to quantify the distribution with fluorescent microscopy, especially when proteins are partially cytosolic. Moreover, it is often important to study endogenous proteins. Biochemical assays such as immunoblots remain the gold standard for quantification of protein distribution after subcellular fractionation...
August 18, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28868637/clinical-performance-of-self-assembling-peptide-p11-4-in-the-treatment-of-initial-proximal-carious-lesions-a-practice-based-case-series
#17
Markus Schlee, Till Schad, Jan H Koch, Philippe C Cattin, Florian Rathe
AIM: The aim of the present study was to investigate the clinical performance of self-assembling peptide P11 -4 on non-cavitated initial proximal carious lesions 12 months after treatment. METHODS: Twenty-six patients, aged between 18 and 65 years, with 35 carious lesions were included in this practice-based, uncontrolled, prospective case series. The opacity and size of the proximal lesions were evaluated visually at baseline and at day 360 using standardized single-tooth or bite-wing and digital-subtraction radiography...
September 3, 2017: Journal of Investigative and Clinical Dentistry
https://www.readbyqxmd.com/read/28868551/cavitation-to-fracture-transition-in-a-soft-solid
#18
Jingtian Kang, Changguo Wang, Shengqiang Cai
When a soft solid such as rubber, gel and soft tissue is subject to hydrostatic tension, a small cavity inside the solid expands. For a neo-Hookean solid, when the hydrostatic tension approaches a critical value: 2.5 times its shear modulus, the initially small cavity can expand unboundedly. Such a phenomenon is usually referred to as cavitation instability in soft solids. Several recent experiments have shown that fractures may occur in the material when the hydrostatic tension is far below the critical value...
September 4, 2017: Soft Matter
https://www.readbyqxmd.com/read/28867377/ultrasound-induced-mild-hyperthermia-improves-the-anticancer-efficacy-of-both-taxol%C3%A2-and-paclitaxel-loaded-nanocapsules
#19
Tanguy Boissenot, Alexandre Bordat, Benoît Larrat, Mariana Varna, Hélène Chacun, Angelo Paci, Vianney Poinsignon, Elias Fattal, Nicolas Tsapis
We study the influence of ultrasound on paclitaxel-loaded nanocapsules in vitro and in vivo. These nanocapsules possess a shell of poly(dl-lactide-co-glycolide)-poly(ethylene glycol) (PLGA-PEG) and a liquid core of perfluorooctyl bromide (PFOB). In vitro experiments show that mechanical effects such as cavitation are negligible for nanocapsules due to their small size and thick and rigid shell. As the mechanical effects were unable to increase paclitaxel delivery, we focused on the thermal effects of ultrasound in the in vivo studies...
September 1, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28865549/effect-of-oocyte-vitrification-on-embryo-quality-time-lapse-analysis-and-morphokinetic-evaluation
#20
Ana Cobo, Aila Coello, Jose Remohí, Jose Serrano, Jose Maria de Los Santos, Marcos Meseguer
OBJECTIVE: To analyze whether oocyte vitrification may affect subsequent embryo development from a morphokinetic standpoint by means of time-lapse imaging. DESIGN: Observational cohort study. SETTING: University-affiliated private IVF center. PATIENT(S): Ovum donation cycles conducted with the use of vitrified (n = 631 cycles; n = 3,794 embryos) or fresh oocytes (n = 1,359 cycles; n = 9,935 embryos) over 2 years. INTERVENTIONS(S): None...
September 2017: Fertility and Sterility
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