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https://www.readbyqxmd.com/read/29227462/psychiatric-disorders-antiretroviral-medication-adherence-and-viremia-in-a-cohort-of-perinatally-hiv-infected-adolescents-and-young-adults
#1
Amelia Bucek, Cheng-Shiun Leu, Stephanie Benson, Patricia Warne, Elaine J Abrams, Katherine S Elkington, Curtis Dolezal, Andrew Wiznia, Claude Ann Mellins
BACKGROUND: Perinatally HIV-infected (PHIV+) adolescents and young adults (AYA) are at risk for sub-optimal antiretroviral therapy (ART) adherence, and mental health and substance use problems that, in HIV-infected adults, predict non-adherence. Studies on the relationship between psychiatric and substance use disorders (SUD) and adherence among PHIV+ AYA are limited, but may be important to informing evidence-based interventions to promote adherence. METHODS: Data were analyzed from three annual follow-up interviews (FU2-4, N=179) in a longitudinal study of PHIV+ AYA...
December 8, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29227443/associations-between-medicare-part-d-and-out-of-pocket-spending-hiv-viral-load-adherence-and-adap-use-in-dual-eligibles-with-hiv
#2
Nadya Belenky, Brian W Pence, Stephen R Cole, Stacie B Dusetzina, Andrew Edmonds, Jonathan Oberlander, Michael W Plankey, Adebola Adedimeji, Tracey E Wilson, Jennifer Cohen, Mardge H Cohen, Joel E Milam, Elizabeth T Golub, Adaora A Adimora
BACKGROUND: The implementation of Medicare part D on January 1, 2006 required all adults who were dually enrolled in Medicaid and Medicare (dual eligibles) to transition prescription drug coverage from Medicaid to Medicare part D. Changes in payment systems and utilization management along with the loss of Medicaid protections had the potential to disrupt medication access, with uncertain consequences for dual eligibles with human immunodeficiency virus (HIV) who rely on consistent prescription coverage to suppress their HIV viral load (VL)...
January 2018: Medical Care
https://www.readbyqxmd.com/read/29224373/pharmacotherapy-and-treatment-options-for-hiv-associated-nephropathy
#3
Steven Menez, Mohamad Hanouneh, Blaithin A McMahon, Derek M Fine, Mohamed G Atta
Human immunodeficiency virus (HIV) remains a worldwide disease with significant mortality and morbidity. There are a multitude of HIV-related kidney diseases including HIV-associated nephropathy (HIVAN) most prominently. The risk of developing HIVAN increases with decreasing CD4 count, higher viral load, and based on genetic factors. The mortality rate for those with HIVAN-end stage renal disease (ESRD) remains 2.5-3 times higher than ESRD patient without HIVAN. Areas Covered: The epidemiology of HIVAN, particularly risk assessment will be explored in this review...
December 9, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29224242/dermoscopic-observations-in-disseminated-cryptococcosis-with-cutaneous-involvement
#4
M Sławińska, M Hlebowicz, E Iżycka-Świeszewska, M Sikorska, M Sokołowska-Wojdyło, T Smiatacz, R Nowicki, M Sobjanek
A 26-year-old female patient with a history of intravenous drug abuse, diagnosed with acquired immunodeficiency syndrome (AIDS) 6 months before. AIDS defining disease was Pneumocystis jiroveci pneumonia. The patient presented with severely decreased CD4 cell count of 7 cells/mm3 and relatively low HIV viral load of 281 copies/mL. Shortly after initiation of antiretroviral therapy (ART), was diagnosed with disseminated cryptococcosis with central nervous system and skin involvement. This article is protected by copyright...
December 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29224045/association-of-adolescent-and-caregiver-reported-antiretroviral-therapy-adherence-with-hiv-viral-load-among-perinatally-infected-south-african-adolescents
#5
Kirsty Brittain, Nana Akua Asafu-Agyei, Jacqueline Hoare, Linda-Gail Bekker, Helena Rabie, James Nuttall, Paul Roux, Dan J Stein, Heather J Zar, Landon Myer
Accurate measurement of antiretroviral therapy (ART) adherence remains challenging and there are few data assessing the validity of self-reported adherence among perinatally HIV-infected adolescents. We examined adolescent and caregiver reports of adolescent adherence among perinatally-infected adolescents aged 9-14 years in Cape Town, South Africa, and explored factors that may modify associations between reported adherence and elevated viral load (VL). Among 474 adolescents (median age 12.0 years; median duration of ART use 7...
December 9, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29223945/-heart-transplantation-in-an-hiv-infected-patient
#6
Pablo Mouras, Laura Barcán, César Belziti, Rodolfo Pizarro, Noelia Mañez, Ricardo Marenchino
Because of its own unfavourable evolution, HIV infection was until recently considered a contraindication for organ transplantation. The introduction of highly active antiretroviral therapy prolonged the life expectancy of these patients and allowed the manifestation of disorders directly or indirectly related to HIV infection, mainly liver, kidney and cardiovascular diseases. We present a case of cardiac transplantation due to dilated cardiomyopathy that was performed in a patient with a recently detected HIV infection...
2017: Medicina
https://www.readbyqxmd.com/read/29223580/modeling-hiv-disease-progression-and-transmission-at-population-level-the-potential-impact-of-modifying-disease-progression-in-hiv-treatment-programs
#7
Jennifer M Ross, Roger Ying, Connie L Celum, Jared M Baeten, Katherine K Thomas, Pamela M Murnane, Heidi van Rooyen, James P Hughes, Ruanne V Barnabas
INTRODUCTION: Mathematical models that incorporate HIV disease progression dynamics can estimate the potential impact of strategies that delay HIV disease progression and reduce infectiousness for persons not on antiretroviral therapy (ART). Suppressive treatment of HIV-positive persons co-infected with herpes simplex virus-2 (HSV-2) with valacyclovir, an HSV-2 antiviral, can lower HIV viral load, but the impact of partially-suppressive valacyclovir relative to fully-suppressive ART on population HIV transmission has not been estimated...
December 5, 2017: Epidemics
https://www.readbyqxmd.com/read/29216405/the-human-immunodeficiency-virus-care-continuum-in-china-1985-2015
#8
Ye Ma, Zhihui Dou, Wei Guo, Yurong Mao, Fujie Zhang, Jennifer M McGoogan, Yan Zhao, Decai Zhao, Yasong Wu, Zhongfu Liu, Zunyou Wu
Background: Human immunodeficiency virus (HIV) care continuum attrition is a major global public health challenge. Few studies have examined this problem in resource-limited settings. We aimed to assess cumulative, current, and historical achievement along China's HIV continuum of care. Methods: A nationwide, serial cross-sectional study of all individuals with HIV infection diagnosed in China between 1 January 1985 and 31 December 2015 was conducted using data from China's HIV/AIDS information systems...
December 5, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29216346/darunavir-ritonavir-monotherapy-at-a-low-dose-600-100%C3%A2-mg-day-in-hiv-1-infected-individuals-with-suppressed-hiv-viraemia
#9
S Seang, L Schneider, T Nguyen, M P Lê, C Soulie, R Calin, F Caby, M-A Valantin, R Tubiana, L Assoumou, A-G Marcelin, G Peytavin, C Katlama
Background: Darunavir/ritonavir is a potent PI with a high genetic barrier and pharmacological robustness favourably investigated as monotherapy. Whether darunavir could be dose reduced in the context of monotherapy deserves investigation. Methods: Patients with HIV suppressed viraemia (plasma viral load <50 copies/mL for 12 months) under ART who had switched to darunavir/ritonavir monotherapy at 600/100 mg/day between 2013 and 2015 were included in this observational 48 week single-centre study...
December 5, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29214223/novel-elvitegravir-nanoformulation-approach-to-suppress-the-viral-load-in-hiv-infected-macrophages
#10
Yuqing Gong, Pallabita Chowdhury, Narasimha M Midde, Mohammad A Rahman, Murali M Yallapu, Santosh Kumar
Purpose: Monocytes serve as sanctuary sites for HIV-1 from which virus is difficult to be eliminated. Therefore, an effective viral suppression in monocytes is critical for effective antiretroviral therapy (ART). This study focuses on a new strategy using nanoformulation to optimize the efficacy of ART drugs in HIV-infected monocytes. Methods: Poly(lactic-co-glycolic acid) (PLGA)-based elvitegravir nanoparticles (PLGA-EVG) were prepared by nano-precipitation technique...
December 2017: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/29212942/factors-leading-to-the-loss-of-natural-elite-control-of-hiv-1-infection
#11
María Pernas, Laura Tarancón-Diez, Esther Rodríguez-Gallego, Josep Gómez, Julia G Prado, Concepción Casado, Beatriz Dominguez-Molina, Isabel Olivares, Maite Coiras, Agathe León, Carmen Rodriguez, Jose Miguel Benito, Norma Rallón, Montserrat Plana, Onofre Martinez-Madrid, Marta Dapena, Jose Antonio Iribarren, Jorge Del Romero, Felipe García, José Alcamí, M Ángeles Muñoz-Fernández, Francisco Vidal, Manuel Leal, Cecilio Lopez-Galindez, Ezequiel Ruiz-Mateos
HIV-1 elite controllers (EC) maintain undetectable viral load (VL) in the absence of antiretroviral treatment. However, these subjects have heterogeneous clinical outcomes including a proportion loosing HIV-1 control over time. In this work we compared, in a longitudinal design, transient EC, analyzed before and after the loss of virological control, versus persistent EC. The aim was to identify factors leading to the loss of natural virological control of HIV-1-infection with a longitudinal retrospective study design...
December 6, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29212937/experimental-adaptive-evolution-of-sivcpz-to-pandemic-hiv-1-using-a-humanized-mouse-model
#12
Kei Sato, Naoko Misawa, Junko S Takeuchi, Tomoko Kobayashi, Taisuke Izumi, Hirofumi Aso, Shumpei Nagaoka, Keisuke Yamamoto, Izumi Kimura, Yoriyuki Konno, Yusuke Nakano, Yoshio Koyanagi
HIV-1, the causative agent of AIDS, is originated from SIVcpz, the chimpanzee precursor of the human virus, approximately 100 years ago. This indicates that HIV-1 has emerged through the cross-species transmission of SIVcpz from chimpanzees to humans. However, it remains unclear how SIVcpz has evolved into pandemic HIV-1 in humans. To address this question, we inoculated three SIVcpz (MB897, EK505, and MT145), four pandemic HIV-1 (NL4-3, NLCSFV3, JRCSF and AD8) and 2 non-pandemic HIV-1 (YBF30 and DJO0131) strains...
December 6, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29212076/resistance-associated-mutations-and-polymorphisms-among-integrase-inhibitor-na%C3%A3-ve-hiv-1-patients-in-kuwait
#13
Wassim Chehadeh, Osama Albaksami, Sonia Elezebeth John, Widad Al-Nakib
OBJECTIVES: Resistance-associated mutations (RAMs) in the integrase of different HIV-1 subtypes were investigated in a cohort of patients never exposed to integrase strand transfer inhibitors (INSTIs). METHODS: The viral RNA was extracted from plasma samples of 53 INSTI-naïve patients, and the integrase genetic region was sequenced and analyzed for subtype assignment and drug resistance. RESULTS: The median viral load at sampling was 5.28 × 104 RNA copies/mL...
December 7, 2017: Intervirology
https://www.readbyqxmd.com/read/29211874/prevalence-incidence-and-clearance-of-anal-high-risk-human-papillomavirus-hpv-infection-among-hiv-infected-men-in-the-sun-study
#14
Pragna Patel, Tim Bush, Erna Milunka Kojic, Lois Conley, Elizabeth R Unger, Teresa M Darragh, Keith Henry, John Hammer, Gerome Escota, Joel M Palefsky, John T Brooks
Background: The natural history of anal HPV infection among HIV-infected men is unknown. Methods: We collected anal swabs for cytology, HPV detection, and genotyping at annual visits from 2004-2012. We examined baseline prevalence, incidence and clearance of anal HPV infection at 48 months, and associated factors among HIV-infected men. Results: We examined 403 men who have sex with men (MSM) and 96 men who have sex with women (MSW) (median age 42 years for both, 87 vs...
December 4, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29211512/durability-of-second-antiretroviral-regimens-in-the-italian-cohort-naive-antiretrovirals-foundation-study-and-factors-associated-with-discontinuation
#15
Antonio Di Biagio, Patrizia Lorenzini, Giulia Gustinetti, Stefano Rusconi, Andrea De Luca, Giuseppe Lapadula, Sergio Lo Caputo, Stefania Cicalini, Francesco Castelli, Giulia Marchetti, Andrea Antinori, Antonella d'Arminio Monforte
The study was designed to investigate the median duration of second antiretroviral regimens and factors associated with early discontinuation in HIV patients who switched with an undetectable viral load. We conducted a retrospective analysis of the Italian Cohort Naive Antiretrovirals Foundation Study (ICONA), which collects data throughout the country. Patients who started first antiretroviral therapy (ART) after January 1, 2008 in any center involved in this cohort and then switched to a second regimen were included in the study...
December 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/29211347/long-term-viral-suppression-and-immune-recovery-during-first-line-antiretroviral-therapy-a-study-of-an-hiv-infected-adult-cohort-in-hanoi-vietnam
#16
Junko Tanuma, Shoko Matsumoto, Sebastien Haneuse, Do Duy Cuong, Tuong Van Vu, Pham Thi Thanh Thuy, Nguyen Thi Dung, Nguyen Thi Hoai Dung, Nguyen Vu Trung, Nguyen Van Kinh, Shinichi Oka
INTRODUCTION: Achieving viral suppression is key in the global strategy to end the HIV epidemic. However, the levels of viral suppression have yet to be described in many resource-limited settings. METHODS: We investigated the time to virologic failure (VF; defined as a viral load of ≥1000 copies/ml) and changes in CD4 counts since starting antiretroviral therapy (ART) in a cohort of HIV-infected adults in Hanoi, Vietnam. Factors related to the time to VF and impaired early immune recovery (defined as not attaining an increase in 100 cells/mm3 in CD4 counts at 24 months) were further analysed...
December 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29210833/influence-of-injection-drug-use-related-hiv-acquisition-on-cd4-response-to-first-antiretroviral-therapy-regimen-among-virally-suppressed-individuals
#17
Keri L Calkins, Catherine R Lesko, Geetanjali Chander, Richard D Moore, Bryan Lau
BACKGROUND: The inflammatory effects of injection drug use may result in an impaired immune response to antiretroviral therapy (ART). We examined CD4 response to first ART regimen among individuals in routine HIV care, stratified by injection drug use-related HIV acquisition. SETTING: Cohort study including patients who initiated ART between 2000-2015 in the Johns Hopkins HIV Clinic. METHODS: We followed individuals from ART initiation until death, loss to follow-up, loss of viral load suppression (<500 copies/mL) or administrative censoring...
November 27, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29210661/impact-of-different-antiretroviral-strategies-on-total-hiv-dna-level-in-virologically-suppressed-hiv-1-infected-patients
#18
Isabella Bon, Leonardo Calza, Giuseppina Musumeci, Serena Longo, Alessia Bertoldi, Vanessa D'Urbano, Davide Gibellini, Eleonora Magistrelli, Pier Luigi Viale, Maria Carla Re
Background Total HIV-DNA load in peripheral blood cell (PBMCs) reflects the global viral reservoir that seems to be not affect by antiretroviral treatment. However, some studies reported a different permeability of different drugs in cellular compartments. Objective To investigate the relation between the amount of total HIV-1 DNA and different treatment strategies. Method Total HIV-1 DNA was quantified by real time PCR in PBMCs collected from 161 patients with long-term undetectable HIV-RNA receiving different therapy schedules (3-drug regimens or 2-drug regimen containing Raltegravir as integrase inhibitor)...
December 6, 2017: Current HIV Research
https://www.readbyqxmd.com/read/29210660/host-factors-predictors-in-long-term-nonprogressors-hiv-1-infected-with-distinct-viral-clades
#19
J S Santos, S M Almeida, G F Silveira, J Bordignon, S Lm Teixeira, Acm Lima, S M Raboni
BACKGROUND: HIV-1+ long-term non-progressors (LTNPs) maintain natural control of viral infection. This study sought to identify and characterize HIV- LTNPs series case, regarding the presence of possible host factors that may be associated with this status. METHODS: We evaluated the plasma levels of IP-10/IL-8 chemokines, HLA-B alleles, and IL28B rs12979860 polymorphism in 24 LTNPs who presented with infection by different clades of HIV-1. RESULTS: IL-8 chemokine was significantly higher in progressors than in LTNPs, but there was no difference between the LTNP subgroups...
December 6, 2017: Current HIV Research
https://www.readbyqxmd.com/read/29210627/pharmacokinetic-analysis-of-nevirapine-extended-release-400%C3%A2-mg-once-daily-vs-nevirapine-immediate-release-200%C3%A2-mg-twice-daily-formulation-in-treatment-na%C3%A3-ve-patients-with-hiv-1-infection
#20
Chan-Loi Yong, Joseph C Gathe, Gabriele Knecht, Catherine Orrell, Josep Mallolas, Daniel Podzamczer, Benoit Trottier, Wei Zhang, John P Sabo, Richard Vinisko, Murray Drulak, Anne-Marie Quinson
BACKGROUND: VERxVE data showed non-inferior virologic efficacy with extended release nevirapine (NVP-XR) dosed 400 mg once daily (QD) versus immediate release nevirapine (NVP-IR) 200 mg twice daily in a double-blind, non-inferiority study in treatment-naïve HIV-1-positive patients. OBJECTIVE: To study the pharmacokinetics (PK) of the NVP formulations and identify possible associations with demographic factors. METHODS: Patients with viral load ≥1000 copies/mL and CD4+ count > 50- <400 cells/mm3 (males) and >50- <250 cells/mm3 (females) at screening received NVP-IR 200 mg QD during a 14-day lead-in and were then stratified by baseline viral load and randomized to NVP-XR or -IR...
November 2017: HIV Clinical Trials
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